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Biomarkers larynx

Yoon Ah Cho, Eun Kyung Kim, Su Jin Heo, Byoung Chul Cho, Hye Ryun Kim, Ji Myung Chung, Sun Och Yoon
The MET pathway plays a key role in various cancers, and its inhibition represents a potential treatment target. However, appropriate biomarkers are needed to facilitate the selection of patients who would benefit from MET inhibiting therapy. We herein conducted a robust confirmatory evaluation of the MET copy number alteration status and prognostic significance of c-Met expression in a large series of patients (n = 396) who underwent standard surgical resection and adjuvant chemoradiotherapy for head and neck squamous cell carcinoma (HNSCC)...
2016: Journal of Cancer
Kathrin Günther, Ronja Foraita, Juliane Friemel, Frauke Günther, Jörn Bullerdiek, Rolf Nimzyk, Dominique Nadine Markowski, Thomas Behrens, Wolfgang Ahrens
BACKGROUND: The transcription factor high-mobility AT-hook 2 (HMGA2) is involved in stem cell renewal and is expressed in many tumor tissues. Head and neck squamous cell carcinomas (HNSCC) comprise tumors of the upper aerodigestive tract and are characterized by high recurrence rates that represent a challenge to patient management. The study addresses the potential of HMGA2 as a molecular biomarker for HNSCC patient survival. METHODS: Patients with HNSCC of the larynx, pharynx, tonsils, or oral cavity were recruited in a hospital-based case-control study (n = 202)...
October 14, 2016: Cancer Epidemiology, Biomarkers & Prevention
Imran Petkar, Keith Rooney, Justin W G Roe, Joanne M Patterson, David Bernstein, Justine M Tyler, Marie A Emson, James P Morden, Kathrin Mertens, Elizabeth Miles, Matthew Beasley, Tom Roques, Shreerang A Bhide, Kate L Newbold, Kevin J Harrington, Emma Hall, Christopher M Nutting
BACKGROUND: Persistent dysphagia following primary chemoradiation (CRT) for head and neck cancers can have a devastating impact on patients' quality of life. Single arm studies have shown that the dosimetric sparing of critical swallowing structures such as the pharyngeal constrictor muscle and supraglottic larynx can translate to better functional outcomes. However, there are no current randomised studies to confirm the benefits of such swallow sparing strategies. The aim of Dysphagia/Aspiration at risk structures (DARS) trial is to determine whether reducing the dose to the pharyngeal constrictors with dysphagia-optimised intensity- modulated radiotherapy (Do-IMRT) will lead to an improvement in long- term swallowing function without having any detrimental impact on disease-specific survival outcomes...
October 6, 2016: BMC Cancer
Kiyoshi Misawa, Daiki Mochizuki, Shiori Endo, Masato Mima, Yuki Misawa, Atsushi Imai, Kazuya Shinmura, Takeharu Kanazawa, Thomas E Carey, Hiroyuki Mineta
The aim of this study was to evaluate the prognostic value of the promoter methylation status of galanin (GAL) and galanin receptor 1/2 (GALR1/2) by assessing their association with disease-free survival and known prognostic factors in head and neck cancer. We generated methylation profiles of GAL and GALR1/2 in tumor samples obtained from 202 patients with head and neck squamous cell carcinoma (HNSCC); these included 43 hypopharynx, 42 larynx, 59 oral cavity, and 58 oropharynx tumor samples. CpG island hypermethylation status of the three genes was analyzed using quantitative methylation-specific PCR (Q-MSP)...
March 2017: Molecular Carcinogenesis
Menachem Gross, Amichay Meirovich, Jakob Rachmut, Ina Kalichman, Tamar Peretz, Ron Eliashar, Vivian Barak
BACKGROUND/AIM: Head and neck cancer (HNC) patients are usually diagnosed with advanced disease and multimodality therapies are required, as well as prognostic biomarkers to predict their response and assess survival. In this study, we aimed to evaluate the ability and clinical significance of the immune biomarker sIL-2R in HNC patients, to assess therapy response and prognosis. MATERIALS AND METHODS: We evaluated 328 blood samples from 145 head and neck cancer patients (HNC) from several subgroups: 84 larynx carcinomas pre- and 39 post-therapy, 46 oral cavity carcinomas pre- and 29 post-therapy, 12 nasopharynx carcinomas, 16 parotid and other salivary gland carcinoma patients...
August 2016: Anticancer Research
Adam Scheel, Emily Bellile, Jonathan B McHugh, Heather M Walline, Mark E Prince, Susan Urba, Gregory T Wolf, Avraham Eisbruch, Francis Worden, Thomas E Carey, Carol Bradford
OBJECTIVES/HYPOTHESIS: Assess tumor suppressor p53 (TP53) functional mutations in the context of other biomarkers in advanced larynx cancer. STUDY DESIGN: Prospective analysis of pretreatment tumor TP53, human papillomavirus (HPV), Bcl-xL, and cyclin D1 status in stage III and IV larynx cancer patients in a clinical trial. METHODS: TP53 exons 4 through 9 from 58 tumors were sequenced. Mutations were grouped using three classifications based on their expected function...
September 2016: Laryngoscope
Soussan Irani
STATEMENT OF THE PROBLEM: Head and neck cancers include epithelial tumors arising in the oral cavity, pharynx, larynx, paranasal sinuses, and nasal cavity. Metastasis is a hallmark of cancer. MicroRNAs (miRNAs) are endogenous small non-coding RNAs involved in cell proliferation, development, differentiation and metastasis. It is believed that miRNA alterations correlate with initiation and progression of cancer cell proliferation or inhibition of tumorigenesis. Moreover, miRNAs have different roles in development, progression, and metastasis of head and neck squamous cell carcinoma (HNSCC)...
June 2016: Journal of Dentistry
Sarah A Flowers, Xin Zhou, Jing Wu, Yiwen Wang, Kepher Makambi, Bhaskar V Kallakury, Mark S Singer, Steven D Rosen, Bruce Davidson, Radoslav Goldman
Sulfatase 2 (SULF2), an extracellular sulfatase that alters sulfation on heparan sulfate proteoglycans, is involved in the tumorigenesis and progression of several carcinomas. SULF2 expression has not been evaluated in squamous cell carcinoma of the head and neck (HNSCC). Here we report results of IHC of SULF2 expression in HNSCC tissue. SULF2 was detected in 57% of tumors (n = 40) with a significant increase in intensity and number of stained cells compared to adjacent cancer-free tissue (p-value < 0.01), increasing with cancer stage when comparing stages 1 and 2 to stages 3 and 4 (p-value 0...
July 12, 2016: Oncotarget
María José de Miguel-Luken, Manuel Chaves-Conde, Begoña Quintana, Alicia Menoyo, Isabel Tirado, Verónica de Miguel-Luken, Jerónimo Pachón, David Chinchón, Vladimir Suarez, Amancio Carnero
Current larynx preservation treatments have achieved an improvement of laryngoesophageal dysfunction-free survival (LDS) but lead to significant toxicities and recurrences. At present, there is no evidence to select the group of patients that may benefit from preservation approaches instead of surgery. Therefore, laryngeal biomarkers could facilitate pretreatment identification of patients who could respond to chemoradiation-based therapy. In this study, we evaluated retrospectively 53 patients with larynx cancer to determine whether gH2AX phosphorylation (pH2AX) alone or in combination with the membrane protein MAP17 (PDZK1IP1) could be used as prognostic biomarkers...
May 31, 2016: Oncotarget
A Hoeben, J Polak, L Van De Voorde, F Hoebers, H I Grabsch, J de Vos-Geelen
BACKGROUND: The aim of this systematic review is to provide an overview of the diagnosis, treatment options and treatment-related complications of cervical esophageal carcinoma (CEC) and to subsequently provide recommendations to improve quality of care. DESIGN: Studies were identified in PubMed, EMBASE and Web of Science. A total of 107 publications fulfilled the inclusion criteria and were included. RESULTS: CEC is uncommon, accounting for 2%-10% of all esophageal carcinomas...
September 2016: Annals of Oncology: Official Journal of the European Society for Medical Oncology
Takuya Kakuki, Makoto Kurose, Ken-Ichi Takano, Atsushi Kondoh, Kazufumi Obata, Kazuaki Nomura, Ryo Miyata, Yakuto Kaneko, Takumi Konno, Syunta Takahashi, Tsubasa Hatakeyama, Takayuki Kohno, Tetsuo Himi, Takashi Kojima
Junctional adhesion molecule-A (JAM-A), which belongs to the IgG superfamily, is a tight junction molecule associated with epithelial and endothelial barrier function. Overexpression of JAM-A is also closely associated with invasion and metastasis of cancers such as breast cancer, lung cancer and pancreatic cancer. However, little is known about the mechanism in overexpression of JAM-A in head and neck squamous cell carcinoma (HNSCC). In the present study, we found high expression of JAM-A at the protein and mRNA levels in HNSCC tissues, including those of the oropharynx, larynx, and hypopharynx, together with high protein expression of β-catenin, p63, ΔNp63 and GATA-3...
June 7, 2016: Oncotarget
María José de Miguel-Luken, Manuel Chaves-Conde, Amancio Carnero
During the recent decades significant improvements in the understanding of laryngeal molecular biology allowed a better characterization of the tumor. However, despite increased molecular knowledge and clinical efforts, survival of patients with laryngeal cancer remains the same as 30 years ago. Although this result may not make major conclusions as preservation approaches were not broadly used until the time of database collection, it seems to be clear that there is still window for improvement. Although the cornerstone for laryngeal cancer eradication is to implement smoking cessation programs, survival progresses will be hopefully seen in the future...
May 2, 2016: Cell Cycle
Xavier Castellsagué, Laia Alemany, Miquel Quer, Gordana Halec, Beatriz Quirós, Sara Tous, Omar Clavero, Llúcia Alòs, Thorsten Biegner, Tomasz Szafarowski, Maria Alejo, Dana Holzinger, Enrique Cadena, Edith Claros, Gillian Hall, Jan Laco, Mario Poljak, Maria Benevolo, Elena Kasamatsu, Hisham Mehanna, Cathy Ndiaye, Núria Guimerà, Belen Lloveras, Xavier León, Juan C Ruiz-Cabezas, Isabel Alvarado-Cabrero, Chang-Suk Kang, Jin-Kyoung Oh, Marcial Garcia-Rojo, Ermina Iljazovic, Oluseyi F Ajayi, Flora Duarte, Ashrafun Nessa, Leopoldo Tinoco, Marco A Duran-Padilla, Edyta C Pirog, Halina Viarheichyk, Hesler Morales, Valérie Costes, Ana Félix, Maria Julieta V Germar, Marisa Mena, Arzu Ruacan, Asha Jain, Ravi Mehrotra, Marc T Goodman, Luis Estuardo Lombardi, Annabelle Ferrera, Sani Malami, Estela I Albanesi, Pablo Dabed, Carla Molina, Rubén López-Revilla, Václav Mandys, Manuel E González, Julio Velasco, Ignacio G Bravo, Wim Quint, Michael Pawlita, Nubia Muñoz, Silvia de Sanjosé, F Xavier Bosch
BACKGROUND: We conducted a large international study to estimate fractions of head and neck cancers (HNCs) attributable to human papillomavirus (HPV-AFs) using six HPV-related biomarkers of viral detection, transcription, and cellular transformation. METHODS: Formalin-fixed, paraffin-embedded cancer tissues of the oral cavity (OC), pharynx, and larynx were collected from pathology archives in 29 countries. All samples were subject to histopathological evaluation, DNA quality control, and HPV-DNA detection...
June 2016: Journal of the National Cancer Institute
Reda J Wilson, A Blythe Ryerson, Simple D Singh, Jessica B King
BACKGROUND: Limited literature is available about cancer in the Appalachian Region. This is the only known analysis of all cancers for Appalachia and non-Appalachia covering 100% of the US population. Appalachian cancer incidence and trends were evaluated by state, sex, and race and compared with those found in non-Appalachian regions. METHODS: US counties were identified as Appalachian or non-Appalachian. Age-adjusted cancer incidence rates, standard errors, and confidence intervals were calculated using the most recent data from the United States Cancer Statistics for 2004 to 2011...
February 2016: Cancer Epidemiology, Biomarkers & Prevention
Murat Emin Güveli, Derya Duranyildiz, Ahmet Karadeniz, Elif Bilgin, Murat Serilmez, Hilal Oguz Soydinc, Vildan Yasasever
We aimed to determine the serum levels of angiogenic factors, namely angiopoietins, in nasopharyngeal and laryngeal carcinoma patients. We also aimed to seek the relation of these molecules with tumor grade and their utility as diagnostic biomarkers. We evaluated angiopoietin 1 and 2 levels innasopharynx and larynx cancer patients before treatment. Angiopoietin 2 levels were significantly elevated in larynx carcinoma patients and tended to be elevated in nasopharynx cancer patients compared with healthy controls...
July 2016: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
(no author information available yet)
The Collegium Ramazzini reaffirms its long-standing position that responsible public health action is to ban all extraction and use of asbestos, including chrysotile. This current statement updates the Collegium's earlier statements with a focus on global health dimensions of asbestos and asbestos-related diseases (ARD). The ARD epidemic will likely not peak for at least a decade in most industrialized countries and for several decades in industrializing countries. Asbestos and ARD will continue to present challenges in the arena of occupational medicine and public health, as well as in clinical research and practice, and have thus emerged as a global health issue...
January 2016: Scandinavian Journal of Work, Environment & Health
Yanan Sun, Lijun Tan, Huijun Li, Xiaowei Qin, Jiangtao Liu
We systematically analyzed the association of nine SNPs of seven key NER pathway genes with the development of laryngeal cancer patients, and investigated whether NER pathway polymorphisms could serve as potential biomarkers for laryngeal cancer risk. 271 patients with pathologically proven laryngeal cancer and 271 control subjects were included in our study. Genotyping of ERCC1 rs11615 and rs2298881, ERCC2 rs13181 and rs50871, ERCC3 rs4150441, ERCC4 rs6498486, ERCC5 rs2094258, XPA rs2808668 and XPC rs2228001 were analyzed by polymerase chain reaction (PCR) coupled with restriction fragment length polymorphism (RFLP)...
2015: International Journal of Clinical and Experimental Pathology
Jayalakshmi Nair, Prachi Jain, Udita Chandola, Vinayak Palve, N R Harsha Vardhan, Ram Bhupal Reddy, Vikram D Kekatpure, Amritha Suresh, Moni Abraham Kuriakose, Binay Panda
Laryngo-pharyngeal squamous cell carcinomas are one of the most common head and neck cancers. Despite the presence of a large body of information, molecular biomarkers are not currently used in the diagnosis, treatment and management of patients for this group of cancer. Here, we have profiled expression of genes and microRNAs of larynx and hypopharynx tumors using high-throughput sequencing experiments. We found that matrix metalloproteinases along with SCEL, CRNN, KRT4, SPINK5, and TGM3 among others have significantly altered expression in these tumors...
July 2015: Genes & Cancer
Yejin Mok, Dong-Koog Son, Young Duk Yun, Sun Ha Jee, Jonathan M Samet
Elevated serum γ-glutamyltransferase (GGT) is a marker of hepatic injury and is associated with risk of chronic disease. However, the value of GGT as a biomarker for cancer risk remains unclear. Therefore, we evaluated the association of serum GGT with cancer incidence among more than 1.6 million Koreans. We included 1,662,087 Koreans (1,108,121 men and 553,966 women aged 20-95 years) who received health insurance from the National Health Insurance Service and had a biennial medical evaluation between 1995 and 1998...
January 15, 2016: International Journal of Cancer. Journal International du Cancer
Yuxuan Wang, Simeon Springer, Carolyn L Mulvey, Natalie Silliman, Joy Schaefer, Mark Sausen, Nathan James, Eleni M Rettig, Theresa Guo, Curtis R Pickering, Justin A Bishop, Christine H Chung, Joseph A Califano, David W Eisele, Carole Fakhry, Christine G Gourin, Patrick K Ha, Hyunseok Kang, Ana Kiess, Wayne M Koch, Jeffrey N Myers, Harry Quon, Jeremy D Richmon, David Sidransky, Ralph P Tufano, William H Westra, Chetan Bettegowda, Luis A Diaz, Nickolas Papadopoulos, Kenneth W Kinzler, Bert Vogelstein, Nishant Agrawal
To explore the potential of tumor-specific DNA as a biomarker for head and neck squamous cell carcinomas (HNSCC), we queried DNA from saliva or plasma of 93 HNSCC patients. We searched for somatic mutations or human papillomavirus genes, collectively referred to as tumor DNA. When both plasma and saliva were tested, tumor DNA was detected in 96% of 47 patients. The fractions of patients with detectable tumor DNA in early- and late-stage disease were 100% (n = 10) and 95% (n = 37), respectively. When segregated by site, tumor DNA was detected in 100% (n = 15), 91% (n = 22), 100% (n = 7), and 100% (n = 3) of patients with tumors of the oral cavity, oropharynx, larynx, and hypopharynx, respectively...
June 24, 2015: Science Translational Medicine
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