Moataz E Mohamed, Abdelrahman Saqr, Christopher Staley, Guillaume Onyeaghala, Levi Teigen, Casey R Dorr, Rory P Remmel, Weihua Guan, William S Oetting, Arthur J Matas, Ajay K Israni, Pamala A Jacobson
The human microbiome is associated with human health and disease. Exogenous compounds, including pharmaceutical products, are also known to be affected by the microbiome, and this discovery has led to the field of pharmacomicobiomics. The microbiome can also alter drug pharmacokinetics and pharmacodynamics, possibly resulting in side effects, toxicities, and unanticipated disease response. Microbiome-mediated effects are referred to as drug-microbiome interactions (DMI). Rapid advances in the field of pharmacomicrobiomics have been driven by the availability of efficient bacterial genome sequencing methods and new computational and bioinformatics tools...
February 16, 2024: Transplantation