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https://www.readbyqxmd.com/read/29763690/the-citrus-flavonone-hesperetin-attenuates-the-nuclear-translocation-of-aryl-hydrocarbon-receptor
#1
Yan Qin Tan, Leo Clement Chiu-Leung, Shu-Mei Lin, Lai K Leung
The environmental polycyclic aromatic hydrocarbons (PAH) and dioxins are carcinogens and their adverse effects have been largely attributed to the activation of AhR. Hesperetin is a flavonone found abundantly in citrus fruits and has been shown to be a biologically active agent. In the present study, the effect of hesperetin on the nuclear translocation of AhR and the downstream gene expression was investigated in MCF-7 cells. Confocal microscopy indicated that 7, 12-dimethylbenz[α]anthracene (DMBA) or 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) -induced nuclear translocation of AhR was deterred by hesperetin treatment...
May 16, 2018: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/29753751/the-aryl-hydrocarbon-receptor-is-indispensable-for-dioxin-induced-defects-in-sexually-dimorphic-behaviors-due-to-the-reduction-in-fetal-steroidogenesis-of-the-pituitary-gonadal-axis-in-rats
#2
Yukiko Hattori, Tomoki Takeda, Arisa Nakamura, Kyoko Nishida, Yuko Shioji, Haruki Fukumitsu, Hideyuki Yamada, Yuji Ishii
Many forms of the toxic effects produced by dioxins and related chemicals take place following activation of the aryl hydrocarbon receptor (AHR). Our previous studies have demonstrated that treating pregnant rats with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), a highly toxic dioxin, attenuates the pituitary expression of gonadotropins to reduce testicular steroidogenesis during the fetal stage, resulting in the impairment of sexually-dimorphic behaviors after the offspring reach maturity. To investigate the contribution of AHR to these disorders, we examined the effects of TCDD on AHR-knockout (AHR-KO) Wistar rats...
May 10, 2018: Biochemical Pharmacology
https://www.readbyqxmd.com/read/29752288/comparison-of-hepatic-nrf2-and-ahr-binding-in-2-3-7-8-tetrachlorodibenzo-p-dioxin-tcdd-treated-mice-demonstrates-nrf2-independent-pkm2-induction
#3
Rance Nault, Claire M Doskey, Kelly A Fader, Cheryl E Rockwell, Timothy R Zacharewski
2,3,7,8-Tetrachlorodibenzo- p -dioxin (TCDD) induces hepatic oxidative stress following activation of the aryl hydrocarbon receptor (AhR). Our recent studies showed TCDD induced pyruvate kinase muscle isoform 2 ( Pkm2 ) as a novel antioxidant response in normal differentiated hepatocytes. To investigate cooperative regulation between nuclear factor, erythroid derived 2, like 2 ( Nrf2 ) and the AhR in the induction of Pkm2 , hepatic ChIP-seq analyses were integrated with RNA-seq time course data from mice treated with TCDD for 2 - 168h...
May 11, 2018: Molecular Pharmacology
https://www.readbyqxmd.com/read/29751436/prenatal-dioxin-exposure-estimated-from-dioxins-in-breast-milk-and-sex-hormone-levels-in-umbilical-cord-blood-in-vietnamese-newborn-infants
#4
Hitomi Boda, Tran Ngoc Nghi, Muneko Nishijo, Pham Ngoc Thao, Pham The Tai, Hoang Van Luong, Tran Hai Anh, Yuko Morikawa, Yoshikazu Nishino, Hisao Nishijo
Dioxin concentrations remain elevated in the environment and humans residing near the former US Air Force base in Bien Hoa city, South Vietnam. We recruited 210 mother-infant pairs for whom breast milk dioxin levels were reported in our previous study. Cord blood samples were collected from 162 mother-infant pairs. We selected 16 cord blood samples with a volume over 20mL and fat content of ≥0.03g. Toxic equivalent levels of polychlorinated dibenzodioxins and polychlorinated dibenzofurans (TEQ-PCDD/Fs) and concentrations of 17 congeners, including 2,3,7,8-tetrachlorodibenzo-p-dioxin (2,3,7,8-TCDD), in cord blood were measured and compared with levels in breast milk (Study 1)...
February 15, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29751400/2-3-7-8-tetrachlorodibenzo-p-dioxin-induces-alterations-in-myogenic-differentiation-of-c2c12-cells
#5
Heidi Q Xie, Yingjie Xia, Tuan Xu, Yangsheng Chen, Hualing Fu, Yunping Li, Yali Luo, Li Xu, Karl W K Tsim, Bin Zhao
Dioxin-induced toxicities that affect the development of the motor system have been proposed since many years. However, cellular evidence and the molecular basis for the effects are limited. In this study, a cultured mouse myoblast cell line, C2C12, was utilized to examine the effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on myogenic differentiation and expression of acetylcholinesterase (AChE), a neuromuscular transmission-related gene. The results showed that TCDD exposure at 10-10  M repressed the myotube formation of C2C12 cells by disturbing the fusion process and suppressing the expression of myosin heavy chain, a myobute structural protein, and not by induction of cytotoxicity...
April 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29748732/site-specific-bioaccumulation-of-polychlorinated-dibenzo-p-dioxins-and-polychlorinated-dibenzofurans-pcdd-pcdfs-in-mothers-and-their-infants-living-in-vicinity-of-bien-hoa-airbase-southern-vietnam
#6
Nguyen Thi Minh Hue, Nguyen Van Thuong, Pham Thi Ngoc Mai, Nguyen Hung Minh
Bien Hoa airbase is located in Dong Nai Province (Southern Vietnam). Several sites within the airbase are highly contaminated by Agent Orange/Dioxin, and thus, they are also commonly named as an Agent Orange/Dioxin hotpot. In the present study, 36 maternal milk samples were collected from primiparas who have lived at least 5 years in four wards, Buu Long, Quang Vinh, Trung Dung and Tan Phong, which are closed to Bien Hoa airbase in order to investigate the level and distribution of Agent Orange/Dioxin exposure in different local communities...
May 10, 2018: Environmental Geochemistry and Health
https://www.readbyqxmd.com/read/29743862/the-aryl-hydrocarbon-receptor-and-retinoid-receptors-cross-talk-at-the-cyp1a1-promoter-in-vitro
#7
Stefanie Hessel-Pras, Anke Ehlers, Albert Braeuning, Alfonso Lampen
The epithelium of the small intestine plays an important role in detoxification processes due to the presence of various xenobiotic-metabolizing enzymes from phase I and II, as well as transport proteins of the ATP-binding cassette superfamily. Exposure to xenobiotics induces the expression of these proteins in the small intestine, with multiple signaling pathways stimulated by exogenous compounds converging at individual gene promoters by mechanisms which have not been fully understood yet. In this context the promoter region of the CYP1A1 gene, encoding the phase I monooxygenase cytochrome P450 1A1, was analyzed by chromatin immunoprecipitation with regard to binding of xeno-sensing receptors following stimulation of Caco-2 cells with agonists of the aryl hydrocarbon receptor (AHR) and retinoid receptors...
2018: EXCLI Journal
https://www.readbyqxmd.com/read/29741588/paternal-developmental-toxicant-exposure-is-associated-with-epigenetic-modulation-of-sperm-and-placental-pgr-and-igf2-in-a-mouse-model
#8
Tianbing Ding, Shilpa Mokshagundam, Paolo F Rinaudo, Kevin G Osteen, Kaylon L Bruner-Tran
Preterm birth (PTB), parturition prior to 37 weeks gestation, is the leading cause of neonatal mortality. The causes of spontaneous PTB are poorly understood; however, recent studies suggest this condition may arise as a consequence of the parental fetal environment. Specifically, we previously demonstrated that developmental exposure of male mice (F1 animals) to the environmental endocrine disruptor 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) was associated with reduced sperm quantity/quality in adulthood and control female partners frequently delivered preterm...
May 7, 2018: Biology of Reproduction
https://www.readbyqxmd.com/read/29726989/a-splicing-mutation-in-aryl-hydrocarbon-receptor-associated-with-retinitis-pigmentosa
#9
Yu Zhou, Shijin Li, Lulin Huang, Yeming Yang, Lin Zhang, Mu Yang, Wenjing Liu, Kim Ramasamy, Zhilin Jiang, Periasamy Sundaresan, Xianjun Zhu, Zhenglin Yang
Retinitis pigmentosa (RP) refers to a group of retinal degenerative diseases, which often lead to vision loss. Although 70 genes have been identified in RP patients, the genetic cause of approximately 30% of RP cases remains unknown. We aimed to identify the cause of the disease in a cohort of RP families by whole exome sequencing. A rare homozygous splicing variant, c.1160 + 1G>A, which introduced skipping of exon 9 of the aryl hydrocarbon receptor (AHR), was identified in family RD-134. This variant is very rare in several exome databases and leads to skipping of exon 9 in the transcript...
May 2, 2018: Human Molecular Genetics
https://www.readbyqxmd.com/read/29705534/increasing-kynurenine-brain-levels-reduces-ethanol-consumption-in-mice-by-inhibiting-dopamine-release-in-nucleus-accumbens
#10
Pablo Giménez-Gómez, Mercedes Pérez-Hernández, María Dolores Gutiérrez-López, Rebeca Vidal, Cristina Abuin-Martínez, Esther O'Shea, María Isabel Colado
Recent research suggests that ethanol (EtOH) consumption behaviour can be regulated by modifying the kynurenine (KYN) pathway, although the mechanisms involved have not yet been well elucidated. To further explore the implication of the kynurenine pathway in EtOH consumption we inhibited kynurenine 3-monooxygenase (KMO) activity with Ro 61-8048 (100 mg/kg, i.p.), which shifts the KYN metabolic pathway towards kynurenic acid (KYNA) production. KMO inhibition decreases voluntary binge EtOH consumption and EtOH preference in mice subjected to "drinking in the dark" (DID) and "two-bottle choice" paradigms, respectively...
April 18, 2018: Neuropharmacology
https://www.readbyqxmd.com/read/29704546/adaptive-changes-in-global-gene-expression-profile-of-lung-carcinoma-a549-cells-acutely-exposed-to-distinct-types-of-ahr-ligands
#11
Jiřina Procházková, Simona Strapáčová, Lucie Svržková, Zdeněk Andrysík, Martina Hýžďalová, Eva Hrubá, Kateřina Pěnčíková, Helena Líbalová, Jan Topinka, Jiří Kléma, Joaquín M Espinosa, Jan Vondráček, Miroslav Machala
Exposure to persistent ligands of aryl hydrocarbon receptor (AhR) has been found to cause lung cancer in experimental animals, and lung adenocarcinomas are often associated with enhanced AhR expression and aberrant AhR activation. In order to better understand the action of toxic AhR ligands in lung epithelial cells, we performed global gene expression profiling and analyze TCDD-induced changes in A549 transcriptome, both sensitive and non-sensitive to CH223191 co-treatment. Comparison of our data with results from previously reported microarray and ChIP-seq experiments enabled us to identify candidate genes, which expression status reflects exposure of lung cancer cells to TCDD, and to predict processes, pathways (e...
April 25, 2018: Toxicology Letters
https://www.readbyqxmd.com/read/29701106/thymoquinone-is-protective-against-2-3-7-8-tetrachlorodibenzo-p-dioxin-induced-hepatotoxicity
#12
M E Erdemli, B Yigitcan, M Gul, H G Bag, S Gul, Z Aksungur
We investigated changes in rat liver tissues following administration of thymoquinone (TQ) against 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) induced hepatotoxicity. Fifty rats were assigned randomly to five groups of 10 as follows: control, corn oil, TCDD, TQ and TCDD + TQ. Biochemical and histopathological analyses were conducted on liver tissue. We found that 30 day TCDD administration caused histopathological changes in liver including thickening of Glisson's capsule, intracytoplasmic vacuolization in hepatocytes, sinusoidal dilation, vascular and sinusoidal congestion and inflammatory cell infiltration...
April 27, 2018: Biotechnic & Histochemistry: Official Publication of the Biological Stain Commission
https://www.readbyqxmd.com/read/29673856/2-3-7-8-tetrachlorodibenzo-p-dioxin-dose-dependently-increases-bone-mass-and-decreases-marrow-adiposity-in-juvenile-mice
#13
Kelly A Fader, Rance Nault, Sandi Raehtz, Laura R McCabe, Timothy R Zacharewski
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) and other aryl hydrocarbon receptor (AhR) agonists have been shown to regulate bone development and remodeling in a species-, ligand-, and age-specific manner, however the underlying mechanisms remain poorly understood. In this study, we characterized the effect of 0.01-30 μg/kg TCDD on the femoral morphology of male and female juvenile mice orally gavaged every 4 days for 28 days and used RNA-Seq to investigate gene expression changes associated with the resultant phenotype...
April 16, 2018: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/29626198/aryl-hydrocarbon-receptor-and-intestinal-immunity
#14
REVIEW
Bruno Lamas, Jane M Natividad, Harry Sokol
Aryl hydrocarbon receptor (AhR) is a member of the basic helix-loop-helix-(bHLH) superfamily of transcription factors, which are associated with cellular responses to environmental stimuli, such as xenobiotics and oxygen levels. Unlike other members of bHLH, AhR is the only bHLH transcription factor that is known to be ligand activated. Early AhR studies focused on understanding the role of AhR in mediating the toxicity and carcinogenesis properties of the prototypic ligand 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)...
April 7, 2018: Mucosal Immunology
https://www.readbyqxmd.com/read/29611660/tooth-development-disorders-in-infants-of-rat-dams-exposed-to-2-3-7-8-tetrachlorodibenzo-p-dioxin-and-protective-role-of-tocopherol-and-acetylsalicylic-acid
#15
M Dobrzyński, U Kaczmarek, P Kuropka, P Reichert, K Grzech-Leśniak, I Całkosiński
Aryl hybrocardon receptor (AhR) activation plays a key role in the pathomechanism of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced defective spatial structure of teeth caused by disordered collagen synthesis. The aim of this study was to identify the influence of dioxins present in female Buffalo rats on the dental structure of their offspring's in the neonatal period and the potential of α-tocopherol and acetylsalicylic acid in curbing post-dioxin hard tissue defects. Research material consisted of molar teeth (n=40) of rat pups which had been given a single dose of TCDD and were then treated with tocopherol or acetylsalicylic acid for 3 weeks...
December 2017: Polish Journal of Veterinary Sciences
https://www.readbyqxmd.com/read/29596651/the-influence-of-obesity-on-the-pharmacokinetics-of-dioxin-in-mice-an-assessment-using-classical-and-pbpk-modeling
#16
C Emond, M J DeVito, J J Diliberto, L S Birnbaum
The effects of body fat mass on the elimination of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) was examined in mice. When male C57BL/6J mice are fed a high-fat, simple carbohydrate diet (HFD) for 13 weeks, they develop an obese phenotype. In contrast, A/J mice fed a HFD do not become obese. After 13 weeks on a normal diet (ND) or HFD, male C57BL/6J and A/J mice received a single dose by gavage of 0.1 or 5.0 µg of 2,3,7,8-tetrachloro[1,6-3H] dibenzo-p-dioxin ([3H]TCDD) per kg bw. Using classical pharmacokinetics, the blood elimination half-life of TCDD was approximately 10 and 2 times longer in the C57BL/6J on the HFD compared with the mice on the ND at 0...
March 27, 2018: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/29584932/structure-dependent-modulation-of-aryl-hydrocarbon-receptor-mediated-activities-by-flavones
#17
Un-Ho Jin, Hyejin Park, Xi Li, Laurie A Davidson, Clinton Allred, Bhimanagouda Patil, Guddadarangavva Jayaprakasha, Asuka A Orr, Leevin Mao, Robert S Chapkin, Arul Jayaraman, Phanourios Tamamis, Stephen Safe
Dietary flavonoids are used in treatment of multiple diseases, and their antiinflammatory effects in the intestine are due, in part, to interactions with gut microflora and possibly due to modulation of aryl hydrocarbon receptor (AhR) signaling. In this study, we investigated the structure-dependent AhR activity of 14 flavonoids in Caco2 colon cancer cells using induction of CYP1A1 and UGT1A1 gene expression as endpoints. A major structural determinant for AhR activation was the number of hydroxyl groups where pentahydroxyflavonoids (with the exception of morin) > hexahydroxyflavonoids > tetra-/trihydroxyflavonoids, and some of the latter compounds such as apigenin exhibited AhR antagonist activity for induction of CYP1A1...
March 23, 2018: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/29569337/diabetes-cardiovascular-disorders-and-2-3-7-8-tcdd-body-burden-in-czech-patients-50-years-after-the-intoxication
#18
Tomas Pelcl, Jan Skrha, Martin Prazny, Stepanka Vlckova, Zdenka Fenclova, Tomas Navratil, Jan Malik, Pavel Diblik, Vit Zikan, Daniela Pelclova
The correlation between 2,3,7,8-tetrachlordibenzo-p-dioxin (TCDD) intoxication and the parameters of metabolic impairment were examined in the last 8 male survivors out of 80 workers exposed to TCDD during the production of herbicides in a chemical factory in 1965-1967. Their median TCDD blood level was 112 (46-390) pg/g lipids and the median TCDD body deposit was 3.9 (0.8-11.7) μg. This puts these patients into the most severely intoxicated group of subjects, according to back-calculated levels of TCDD. The median TCDD blood level in 8 controls was 12 pg/g (<0...
March 22, 2018: Basic & Clinical Pharmacology & Toxicology
https://www.readbyqxmd.com/read/29550351/peripubertal-serum-dioxin-concentrations-and-subsequent-sperm-methylome-profiles-of-young-russian-adults
#19
J Richard Pilsner, Alex Shershebnev, Yulia Medvedeva, Alexander Suvorov, Haotian Wu, Andrey Goltsov, Evgeny Loukianov, Tatiana Andreeva, Fedor Gusev, Andrey Manakhov, Luidmila Smigulina, Maria Logacheva, Victoria Shtratnikova, Irina Kuznetsova, Peter Speranskiy-Podobed, Jane S Burns, Paige L Williams, Susan Korrick, Mary M Lee, Evgeny Rogaev, Russ Hauser, Oleg Sergeyev
BACKGROUND: The association of exposure to endocrine disrupting chemicals in the peripubertal period with subsequent sperm DNA methylation is unknown. OBJECTIVE: We examined the association of peripubertal serum 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) concentrations with whole-genome bisulfite sequencing (WGBS) of sperm collected in young adulthood. METHODS: The Russian Children's Study is a prospective cohort of 516 boys who were enrolled at 8-9 years of age and provided semen samples at 18-19 years of age...
March 14, 2018: Reproductive Toxicology
https://www.readbyqxmd.com/read/29541735/quercetin-3-o-%C3%AE-l-arabinopyranoside-protects-against-retinal-cell-death-via-blue-light-induced-damage-in-human-rpe-cells-and-balb-c-mice
#20
Jun Kim, Hong Lan Jin, Dae Sik Jang, Kwang Won Jeong, Se-Young Choung
Age-related macular degeneration (AMD) is among the increasing number of diseases causing irreversible blindness in the elderly. Dry AMD is characterized by the accumulation of lipofuscin in retinal pigment epithelium (RPE) cells. N-Retinylidene-N-retinylethanolamine (A2E), a component of lipofuscin, is oxidized to oxo-A2E under blue light illumination, leading to retinal cell death. The aim of this study was to investigate the protective effect and mechanism of quercetin-3-O-α-l-arabinopyranoside (QA) against blue light (BL)-induced damage in both RPE cells and mice models...
March 15, 2018: Food & Function
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