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https://www.readbyqxmd.com/read/29136567/persistent-organic-pollutants-in-red-and-white-blooded-high-antarctic-notothenioid-fish-from-the-remote-weddell-sea
#1
Anneli Strobel, Peter Schmid, Patricia Burkhardt-Holm, Helmut Segner, Markus Zennegg
It has been suggested that High-Antarctic waters, despite their remoteness from human activities, are impacted by anthropogenic pollution, and that the local biota are accumulating the contaminants. At present, no data exist on persistent organic pollutant (POP) body burdens for notothenioid fish inhabiting the High-Antarctic Weddell Sea. We determined the pollutant load in white muscle tissue of red- and white-blooded notothenoids from the Weddell Sea (Trematomus loennbergii and Chionodraco hamatus, respectively), and compared them to our previous measurements of POPs in Low-Antarctic notothenioids...
November 7, 2017: Chemosphere
https://www.readbyqxmd.com/read/29109131/carbidopa-a-selective-ah-receptor-modulator-sahrm
#2
Stephen Safe
The aryl hydrocarbon receptor (AhR) was discovered as the intracellular receptor that bound with high affinity to the environmental toxicant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), and the AhR is required for mediating the toxicity induced by TCDD. Subsequent studies show that the AhR binds structurally diverse chemicals including plant-derived compounds that promote health and several AhR-active pharmaceuticals that exhibit anticancer activity. In this issue, there is a report that carbidopa, a drug used for treating Parkinson's disease, is also an AhR ligand, and this compound inhibits pancreatic cancer cell and tumor growth...
November 6, 2017: Biochemical Journal
https://www.readbyqxmd.com/read/29107029/transcriptional-inhibition-of-tcdd-mediated-induction-of-cytochrome-p450-1a1-and-alteration-of-protein-expression-in-a-zebrafish-hepatic-cell-line-following-the-administration-of-tcdd-and-cd-2
#3
Ying Ying Chen, King Ming Chan
We studied the effects of Cd(2+) on TCDD-mediated induction of the cytochrome P450 1A1 (cyp1a1) gene using a zebrafish liver cell line (ZFL). Our results showed that Cd(2+) inhibited the TCDD-mediated induction of the cyp1a1 protein, enzyme activity, and mRNA expression level. Cd(2+) also down-regulated levels of the aryl hydrocarbon receptor (ahr2) and the aryl hydrocarbon receptor nuclear translocator 2b (arnt2b) mRNAs. Compared with TCDD (3nM) treatment alone, co-treatment with Cd(2+) (0-30μM) and TCDD (3nM) significantly inhibited the activity of the luciferase reporter gene constructs harboring the distal promoter region (P-2626/-2009) of CYP1A1 and the synthetic 3XRE gene promoter...
October 26, 2017: Toxicology Letters
https://www.readbyqxmd.com/read/29093374/-molecular-mechanism-whereby-maternal-exposure-to-dioxin-suppresses-sexual-maturation-of-the-offspring-after-growing-up
#4
Tomoki Takeda
 Dioxins, including 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), are responsible for producing serious toxic effects in the next generation, such as sexual immaturity. Our laboratory found that treating pregnant rats on gestational day 15 with TCDD (1 μg/kg orally) targets pituitary luteinizing hormone (LH) to attenuate testicular steroidogenesis in fetuses. Because sex steroids during a short window ("the critical period") in the perinatal stage stimulate brain differentiation closely linked to sexual maturation, it is likely that TCDD imprints sexual immaturity on the offspring due to the lowered expression of LH during the fetal period...
2017: Yakugaku Zasshi: Journal of the Pharmaceutical Society of Japan
https://www.readbyqxmd.com/read/29092071/the-regulation-mechanisms-of-ahr-by-molecular-chaperone-complex
#5
Ikuru Kudo, Miki Hosaka, Asami Haga, Noriko Tsuji, Yuhtaroh Nagata, Hirotaka Okada, Kana Fukuda, Yuka Kakizaki, Tomoya Okamoto, Ewa Grave, Hideaki Itoh
The AhR, so called the dioxin receptor, is a member of the nuclear receptor superfamily. The ligand-free AhR forms a cytosolic protein complex with the molecular chaperone HSP90, co-chaperone p23, and XAP2 in the cytoplasm. Following ligand binding like 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD), the AhR translocates into the nucleus. Although it has been reported that HSP90 regulates the translocation of the AhR to the nucleus, the precise activation mechanisms of the AhR have not yet been fully understood...
October 28, 2017: Journal of Biochemistry
https://www.readbyqxmd.com/read/29091793/differential-sensitivities-to-dioxin-like-compounds-pcb-126-and-pecdf-between-tg-cyp1a-gfp-transgenic-medaka-and-zebrafish-larvae
#6
Hongyan Xu, Caixia Li, Pacharaporn Suklai, Qinghua Zeng, Raymond Chong, Zhiyuan Gong
It has been intensively documented that there are species-differences in the sensitivity to dioxin-like compounds (DLCs) in mammalian and avian. However, this issue is still unclear in fish. This study aimed at evaluating the differential sensitivities to DLCs in fish larvae. Here, larvae of Tg(cyp1a:gfp) medaka and Tg(cyp1a:gfp) zebrafish were tested with 2,3,7,8-Tetrachlorodibenzodioxin (TCDD), polychlorinated biphenyl 126 (PCB 126) and 2,3,4,7,8,-Pentachlorodibenzofuran (PeCDF). Comparative analyses were performed on induction of GFP fluorescence, expression of endogenous cyp1a mRNAs and EROD activity between the two species after exposure to these chemicals...
October 29, 2017: Chemosphere
https://www.readbyqxmd.com/read/29081343/lncrna-h19-and-target-gene-mediated-cleft-palate-induced-by-tcdd
#7
Li Yun Gao, Feng Quan Zhang, Wei Hui Zhao, Guang Liang Han, Xiao Wang, Qiang Li, Shan Shan Gao, Wei Dong Wu
This study investigated the role of long non-coding RNAs (lncRNAs) in the development of the palatal tissues. Cleft palates in mice were induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Expression levels of long non-coding RNA H19 (lncRNA H19) and insulin-like growth factor 2 (IGF2) gene were measured by quantitative real-time polymerase chain reaction (qRT-PCR). The rate of occurrence of cleft palate was found to be 100% by TCDD exposure, and TCDD could cause short upper limb, cerebral fissure, webbed neck, and short neck...
September 2017: Biomedical and Environmental Sciences: BES
https://www.readbyqxmd.com/read/29081026/2-3-7-8-tetrachlorodibenzo-p-dioxin-influences-bovine-herpesvirus-1-replication-through-upregulation-of-sirt3-and-cytoskeletal-reorganization
#8
Filomena Fiorito, Valentina Iovane, Annarosaria Marullo, Anna Costagliola, Giovanna Elvira Granato, Luisa De Martino
Infection of kidney cells (MDBK) with Bovine Herpesvirus 1 (BoHV-1) is affected by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), which accelerates BoHV-1-induced apoptosis and increases virus replication. Herein, to elucidate the mechanism through TCDD modifies BoHV-1 infection, we analyzed the modulation of a members of Sirtuin proteins family in MDBK cells. We found that mitochondrial SIRT3 was upregulated during infection. This change was accompanied by cytoskeletal rearrangements and cell extensions. All these trends were drastically modified by TCDD...
December 2017: Veterinary Research Communications
https://www.readbyqxmd.com/read/29057067/identification-of-a-unique-gene-expression-signature-in-mercury-and-2-3-7-8-tetrachlorodibenzo-p-dioxin-co-exposed-cells
#9
Lakshmanan Jagannathan, Cynthia C Jose, Vinay Singh Tanwar, Sudin Bhattacharya, Suresh Cuddapah
Mercury (Hg) and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) are major environmental contaminants that commonly co-occur in the environment. Both Hg and TCDD are associated with a number of human diseases including cancers. While the individual toxicological effects of Hg and TCDD have been extensively investigated, studies on co-exposure are limited to a few genes and pathways. Therefore, a significant knowledge gap exists in the understanding of the deleterious effects of co-exposure to Hg and TCDD. Due to the prevalence of Hg and TCDD co-contamination in the environment and the major human health hazards they pose, it is important to obtain a fuller understanding of genome-wide effects of Hg and TCDD co-exposure...
May 1, 2017: Toxicology Research
https://www.readbyqxmd.com/read/29053996/toxicological-and-chemical-insights-into-representative-source-and-drinking-water-in-eastern-china
#10
Peng Shi, Sicong Zhou, Hongxia Xiao, Jingfan Qiu, Aimin Li, Qing Zhou, Yang Pan, Henner Hollert
Drinking water safety is continuously threatened by the emergence of numerous toxic organic pollutants (TOPs) in environmental waters. In this study, an approach integrating in vitro bioassays and chemical analyses was performed to explore toxicological profiles of representative source and drinking water from waterworks of the Yangtze River (Yz), Taihu Lake (Th), and the Huaihe River (Hh) basins in eastern China. Overall, 34 of 96 TOPs were detected in all water samples, with higher concentrations in both source and drinking water samples of Hh, and pollutant profiles also differed across different river basins...
October 17, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/29043426/roles-of-cytosolic-phospholipase-a2%C3%AE-in-reproductive-and-systemic-toxicities-in-2-3-7-8-tetrachlorodibenzo-p-dioxin-exposed-mice
#11
Nozomi Fujisawa, Wataru Yoshioka, Hiroyuki Yanagisawa, Chiharu Tohyama
Exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) induces a variety of toxicities upon binding of TCDD to aryl hydrocarbon receptor. Although this binding upregulates the synthesis of prostaglandins and their related lipid mediators via cytosolic phospholipase A2α (cPLA2α), toxicological significance of this signaling pathway remains elusive. Herein, we investigated the roles of cPLA2α in TCDD toxicities using cPLA2α-null mice. In a first set of experiments, pregnant mice were orally administered TCDD at a dose of 40 μg/kg on gestation day (GD) 12...
October 17, 2017: Archives of Toxicology
https://www.readbyqxmd.com/read/29040756/tcdd-ficz-and-other-high-affinity-ahr-ligands-dose-dependently-determine-the-fate-of-cd4-t-cell-differentiation
#12
Allison K Ehrlich, Jamie M Pennington, William H Bisson, Siva K Kolluri, Nancy I Kerkvliet
FICZ and TCDD, two high affinity AhR ligands, are reported to have opposite effects on T cell differentiation with TCDD inducing regulatory T cells and FICZ inducing Th17 cells. This dichotomy has been attributed to ligand-intrinsic differences in AhR activation, although differences in sensitivity to metabolism complicates the issue. TCDD is resistant to AhR-induced metabolism and produces sustained AhR activation following a single dose in the μg/kg range while FICZ is rapidly metabolized and AhR activation is transient...
October 13, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/29031942/morbidity-in-new-zealand-pesticide-producers-exposed-to-2-3-7-8-tetrachlorodibenzo-p-dioxin-tcdd
#13
Andrea 't Mannetje, Amanda Eng, Chris Walls, Evan Dryson, Jeroen Douwes, Pier Bertazzi, Simon Ryder-Lewis, David Scott, Collin Brooks, Dave McLean, Soo Cheng, Neil Pearce
OBJECTIVES: To conduct a cross-sectional morbidity survey among 245 former employees of a pesticide production plant exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in New Zealand. METHODS: Demographic factors and health information were collected in face-to-face interviews. TCDD, lipids, thyroid hormones, glucose and immunoglobulin G (IgG) were determined in non-fasting blood. For 111 participants, a neurological examination was conducted. Associations between health outcomes and working in a TCDD exposed job (prevalence 49%) and serum TCDD concentration≥10pg/g lipid (18%) were assessed using logistic regression whilst controlling for age, gender, smoking, body mass index and ethnicity...
January 2018: Environment International
https://www.readbyqxmd.com/read/29029351/development-and-application-of-a-dual-rat-and-human-ahr-activation-assay
#14
Martin R Brown, Helen Garside, Emma Thompson, Saseela Atwal, Chloe Bean, Tony Goodall, Michael Sullivan, Mark J Graham
Significant prolonged AHR activation, classically exhibited following exposure to TCDD (dioxin), can cause a variety of undesirable toxicological effects. Novel pharmaceutical chemistries also have the potential to cause activation of AHR and consequent toxicities in pre-clinical species and man. Previous methods either employed relatively expensive and low throughput primary hepatocyte dosing with PCR endpoint, or low resolution overexpressing reporter gene assays. We have developed, validated and applied an in vitro microtitre plate imaging-based medium throughput screening assay for the assessment of endogenous species-specific AHR activation potential via detection of induction of the surrogate transcriptional target Cytochrome P450 CYP1A1...
September 18, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/29017096/enhancing-mir-132-expression-by-aryl-hydrocarbon-receptor-attenuates-tumorigenesis-associated-with-chronic-colitis
#15
Abdullah M Alzahrani, Hamza Hanieh, Hairul-Islam Mohamed Ibrahim, Omar Mohafez, Tamer Shehata, Mohammad Bani Ismail, Manal Alfwuaires
BACKGROUND: Chronic inflammation in ulcerative colitis (UC) patients is the major risk factor for colitis-associated colon cancer (CAC). Recent evidences have shown that microRNAs (miRNAs) are implicated in CAC pathogenesis. However, the interaction of miRNAs with the transcription factors that alleviate CAC has not been reported. METHODS: 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) or 3,3'-diindolylmethane (DIM) were used to activate aryl hydrocarbon receptor (Ahr) in azoxymethane (AOM)/dextran sodium sulfate (DSS)-induced CAC in mice...
October 7, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28984379/use-of-pcb-and-teq-concentrations-in-scat-from-mink-neovison-vison-fed-fish-from-the-upper-hudson-river-to-predict-dietary-and-hepatic-concentrations-and-health-effects
#16
Steven J Bursian, John Kern, Richard E Remington, Jane E Link
To evaluate health effects associated with consumption of PCB-contaminated fish from the upper Hudson River, farm-raised mink were fed diets containing fish collected from the river. Endpoints assessed included adult reproductive performance, offspring growth and mortality, and organ mass and pathology of adults and their offspring. Scat samples were collected from adult males at the time of necropsy and from adult females just prior to whelping. Scat samples were analyzed for polychlorinated biphenyls (PCBs), polychlorinated dibenzo-p-dioxins (PCDDs) and polychlorinated dibenzofurans (PCDFs)...
October 6, 2017: Environmental Toxicology and Chemistry
https://www.readbyqxmd.com/read/28973660/high-susceptibility-of-lrig1-sebaceous-stem-cells-to-tcdd-in-mice
#17
F Fontao, L Barnes, G Kaya, J H Saurat, O Sorg
We have previously shown that CYP1A1 was highly induced for a long period of time in a patient who had been poisoned by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), a compound known to activate the aryl hydrocarbon receptor (AhR). During that period of time no sebaceous glands could be observed in the skin of this patient. In the present study, starting from observations in the patient exposed to TCDD, we analysed the seboatrophy induced by dioxins in mice. We observed a very different pattern of AhR and CYP1A1 immunostaining in skin biopsies of the patient...
August 30, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/28973413/aryl-hydrocarbon-receptor-ablation-in-cardiomyocytes-protects-male-mice-from-heart-dysfunction-induced-by-nkx2-5-haploinsufficiency
#18
Qin Wang, Yunxia Fan, Hisaka Kurita, Min Jiang, Sheryl Koch, Marepalli B Rao, Jack Rubinstein, Alvaro Puga
Epidemiological studies in humans and research in vertebrates indicates that developmental exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), a ubiquitous and biopersistent environmental toxicant, is associated with incidence of early congenital heart disease in the embryo and later in the adult. TCDD-mediated toxicity depends on the aryl hydrocarbon receptor (AHR) but the role of the TCDD-activated AHR in cardiac function is not well-defined. To characterize the mechanisms responsible for AHR-mediated disruption of heart function, we generated several mouse strains with cardiomyocyte-specific Ahr gene knockout...
November 1, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/28973351/editor-s-highlight-ah-receptor-activation-potentiates-neutrophil-chemoattractant-c-x-c-motif-ligand-5-expression-in-keratinocytes-and-skin
#19
Kayla J Smith, Jacob A Boyer, Gulsum E Muku, Iain A Murray, Krishne Gowda, Dhimant Desai, Shantu G Amin, Adam B Glick, Gary H Perdew
Chemokines are components of the skin microenvironment, which enable immune cell chemotaxis. Traditionally, transcription factors involved in inflammatory signaling (eg, NFκB) are important mediators of chemokine expression. To what extent xenobiotics and their associated receptors control chemokine expression is poorly understood. The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor known to mediate physiological responses in the skin through the regulation of genes involved in xenobiotic metabolism, epidermal differentiation, and immunity...
November 1, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/28948239/beyond-the-aryl-hydrocarbon-receptor-pathway-interactions-in-the-hepatotoxicity-of-2-3-7-8-tetrachlorodibenzo-p-dioxin-and-related-compounds
#20
Kelly A Fader, Timothy R Zacharewski
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is the prototypical ligand for a group of environmental halogenated aromatic hydrocarbon contaminants which elicit hepatotoxicity and other toxic responses through activation of the aryl hydrocarbon receptor (AhR). Despite the conservation of the AhR and its signaling pathway, TCDD-elicited differential gene expression networks are species-specific, consistent with differences in sensitivity and toxic responses between species. This review integrates gene expression studies with complementary phenotypic analyses (e...
February 2017: Current Opinion in Toxicology
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