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https://www.readbyqxmd.com/read/29662437/ketogenic-diet-improves-brain-ischemic-tolerance-and-inhibits-nlrp3-inflammasome-activation-by-preventing-drp1-mediated-mitochondrial-fission-and-endoplasmic-reticulum-stress
#1
Min Guo, Xun Wang, Yanxin Zhao, Qi Yang, Hongyan Ding, Qiang Dong, Xingdong Chen, Mei Cui
Background : Neuroprotective effects of ketogenic diets (KD) have been reported in stroke models, and nucleotide-binding domain (NOD)-like receptor protein 3 (NLRP3) inflammasome has also been implicated in the pathogenesis of stroke. This study aimed to investigate the effects of KD on NLRP3 inflammasome and explore the potential molecular mechanisms. Methods : In in vivo study, mice were fed with KD for 3 weeks and then subjected to middle cerebral artery occlusion/reperfusion (MCAO/R)-injury. In in vitro study, SH-SY-5Y cells were treated with β-hydroxybutyrate (BHB) followed by oxygen-glucose deprivation/reoxygenation (OGD/R)...
2018: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/29656429/citalopram-attenuated-neurobehavioral-biochemical-and-metabolic-alterations-in-transient-middle-cerebral-artery-occlusion-model-of-stroke-in-male-wistar-rats
#2
Sangeetha Gupta, Deepti Upadhayay, Uma Sharma, Naranamangalam R Jagannathan, Yogendra Kumar Gupta
Oxidative stress and inflammation are implicated as cardinal mechanisms of neuronal death following stroke. In the present study citalopram (Cit) was investigated in a 2 h middle cerebral artery occlusion (MCAo) model of stroke in male Wistar rats. Pretreatment, posttreatment (Post Cit) and pre plus posttreatment (Pre + Post Cit) with Cit were evaluated for its neuroprotective effect. In pretreatment protocol, effect of Cit at three doses (2, 4, and 8 mg/kg) administered i.p., 1 h prior to MCAo was evaluated using neurological deficit score (NDS), motor deficit paradigms, and cerebral infarction 24 h post-MCAo...
April 15, 2018: Journal of Neuroscience Research
https://www.readbyqxmd.com/read/29626425/salidroside-improves-brain-ischemic-injury-by-activating-pi3k-akt-pathway-and-reduces-complications-induced-by-delayed-tpa-treatment
#3
Wei Zuo, Feng Yan, Bo Zhang, Xiaomin Hu, Dan Mei
Cerebral ischemia causes blood-brain barrier (BBB) injury and thus increases the risk of complications secondary to thrombolysis, which limited its clinical application. This study aims to clarify the role and mechanism of salidroside (SALD) in alleviating brain ischemic injury and whether pretreatment of it could improve prognosis of delayed treatment of tissue plasminogen activator (t-PA). Rats were subjected to 3h of middle cerebral artery occlusion (MCAO) and were intraperitoneally administered with 10, 20 or 40mg/kg SALD before ischemia...
April 4, 2018: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29615782/preventive-effect-of-low-intensity-pulsed-ultrasound-against-experimental-cerebral-ischemia-reperfusion-injury-via-apoptosis-reduction-and-brain-derived-neurotrophic-factor-induction
#4
Chang-Mu Chen, Cheng-Tien Wu, Ting-Hua Yang, Shing-Hwa Liu, Feng-Yi Yang
Stroke is known as the top 10 causes of death worldwide. Development of effectively neuroprotective or preventive strategies for ischemia stroke is imperative. For the purpose of stroke prevention, we tested the neuroprotective effects of low-intensity pulsed ultrasound (LIPUS) on ischemic stroke. Adult C57BL/6 mice were used to daily treatment with LIPUS for 5 days on left hemisphere before middle cerebral artery occlusion (MCAO)-induced cerebral ischemia/reperfusion injury. Western blotting and immunohistochemistry were performed to assess the protein expressions of signaling molecules...
April 3, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29602953/indole-3-carbinol-improves-neurobehavioral-symptoms-in-a-cerebral-ischemic-stroke-model
#5
Pankaj Paliwal, Gaurav Chauhan, Deepa Gautam, Debabrata Dash, Shashikant C U Patne, Sairam Krishnamurthy
Stroke is one of the most common causes of death worldwide and also responsible for permanent disability. Ischemic stroke has been found to affect 80% of stroke patients. Recombinant tissue plasminogen activator (rtPA) is the widely used drug for the ischemic stroke with narrow therapeutic window. Indole-3-carbinol (I3C) is a natural compound obtained from brassica species having antithrombotic activity. Middle cerebral artery occlusion (MCAO) model was used followed by reperfusion after 2 h of ischemia for the evaluation of the I3C against ischemic stroke...
March 30, 2018: Naunyn-Schmiedeberg's Archives of Pharmacology
https://www.readbyqxmd.com/read/29576054/salvianolic-acid-a-attenuates-ischemia-reperfusion-induced-rat-brain-damage-by-protecting-the-blood-brain-barrier-through-mmp-9-inhibition-and-anti-inflammation
#6
Wen Zhang, Jun-Ke Song, Xue Zhang, Qi-Meng Zhou, Guo-Rong He, Xiao-Na Xu, Yan Rong, Wen-Xia Zhou, Guan-Hua DU
Salvianolic acid A (SAA) is a water-soluble component from the root of Salvia Miltiorrhiza Bge, a traditional Chinese medicine, which has been used for the treatment of cerebrovascular diseases for centuries. The present study aimed to determine the brain protective effects of SAA against cerebral ischemia reperfusion injury in rats, and to figure out whether SAA could protect the blood brain barrier (BBB) through matrix metallopeptidase 9 (MMP-9) inhibition. A focal cerebral ischemia reperfusion model was induced by middle cerebral artery occlusion (MCAO) for 1...
March 2018: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/29571866/dapk1-erk-signal-mediates-oxygen-glucose-deprivation-reperfusion-induced-apoptosis-in-mouse-n2a-cells
#7
Wei Xiong, Yan Wu, Wenjing Xian, Limin Song, Lisha Hu, Shangwen Pan, Min Liu, Shanglong Yao, Lei Pei, You Shang
AIMS: Death-associated protein kinase 1 (DAPK1) is a kinase found to promote neuronal apoptosis induced by ischemia. Extracellular signal-regulated kinase (ERK) was identified as a key molecule in DAPK1 signaling. However, the mechanisms of neuronal ischemia reperfusion injury remain unknown. Here, we investigate the influence of DAPK1-ERK signal on neuronal apoptosis following ischemia reperfusion. METHODS: Mouse N2a cells were used in this study and primary cultured neurons along with mice were adopted as supplements...
April 15, 2018: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/29563983/protective-effects-of-paeonol-on-subacute-chronic-brain-injury-during-cerebral-ischemia-in-rats
#8
Bing Zhao, Qiao-Juan Shi, Zhen-Zhong Zhang, Shu-Yan Wang, Xi Wang, Hao Wang
Ischemic stroke is a highly complex pathological process that is divided into acute, subacute and chronic phases. Paeonol is a biologically active natural product with a variety of pharmacological effects, including those on neuronal activity. However, the effects of paeonol on subacute/chronic ischemic stroke have remained to be elucidated. The present study was designed to investigate the effects of paeonol against subacute and chronic cerebral ischemic injury and to explore the possible underlying mechanisms...
April 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29554649/pioglitazone-confers-neuroprotection-against-ischemia-induced-pyroptosis-due-to-its-inhibitory-effects-on-hmgb-1-rage-and-rac1-ros-pathway-by-activating-ppar-%C3%A9
#9
Pingping Xia, Yundan Pan, Fan Zhang, Na Wang, E Wang, Qulian Guo, Zhi Ye
BACKGROUND/AIMS: Recent researches highlighted the protective potential of pioglitazone, a PPAR-γ agonist, in the progression of cerebral ischemia-reperfusion injury. However, there has been no study on the application of pioglitazone in treating ischemic stroke through mechanisms involving pyroptosis. METHODS: The cerebral injury was established by middle cerebral artery occlusion (MCAO). in vitro ischemia in primary cultured astrocytes was induced by the oxygen-glucose deprivation (OGD)...
March 13, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29551652/edaravone-a-free-radical-scavenger-protects-neuronal-cells-mitochondria-from-ischemia-by-inactivating-another-new-critical-factor-of-the-5-lipoxygenase-pathway-affecting-the-arachidonic-acid-metabolism
#10
Ying Song, Yun Bei, Yan Xiao, Hai-Da Tong, Xie-Qi Wu, Man-Ting Chen
To investigate the neuroprotective effect of edaravone was dependent on 5-lipoxygenase (5-LOX) signalling pathway or not. Middle cerebral artery occlusion (MCAO) and oxygen glucose deprivation (OGD) were established in SD rats and PC12 cells to mimic ischemic injury. In vivo, edaravone can significantly reduce neurological deficit scores, infarct volume and expression of 5-LOX. For in vitro experiment, reduced viability, cell death which occurred via necrosis and apoptosis were shown after OGD and even severer in OGD-reperfusion (OGD-R)...
March 15, 2018: Brain Research
https://www.readbyqxmd.com/read/29549732/micrna-320-facilitates-the-brain-parenchyma-injury-via-regulating-igf-1-during-cerebral-i-r-injury-in-mice
#11
Lizhen Liang, Jun Wang, Yanrong Yuan, Yan Zhang, Huili Liu, Chunli Wu, Yongxing Yan
PURPOSE: To investigate the protective effects of miR-320 on cerebral ischemia/reperfusion (I/R) injury in mice and PC12 cells. METHODS: miR-320 normal control (NC), inhibitor fragment and overexpression fragments were injected into mice lateral ventricles. Thereafter, the middle cerebral artery occlusion (MCAO) for left cerebrum method was employed in order to establish a cerebral I/R injury mice model. Apoptosis in the peripheral region of cerebral infarction and the volume of cerebral infarction and brain edema were tested as well...
March 14, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29521586/upregulation-of-mir-216a-exerts-neuroprotective-effects-against-ischemic-injury-through-negatively-regulating-jak2-stat3-involved-apoptosis-and-inflammatory-pathways
#12
Yu Shuang Tian, Di Zhong, Qing Qing Liu, Xiu Li Zhao, Hong Xue Sun, Jing Jin, Hai Ning Wang, Guo Zhong Li
OBJECTIVE Ischemic stroke remains a significant cause of death and disability in industrialized nations. Janus tyrosine kinase (JAK) and signal transducer and activator of transcription (STAT) of the JAK2/STAT3 pathway play important roles in the downstream signal pathway regulation of ischemic stroke-related inflammatory neuronal damage. Recently, microRNAs (miRNAs) have emerged as major regulators in cerebral ischemic injury; therefore, the authors aimed to investigate the underlying molecular mechanism between miRNAs and ischemic stroke, which may provide potential therapeutic targets for ischemic stroke...
March 9, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29510140/pentose-phosphate-pathway-activation-via-hsp27-phosphorylation-by-atm-kinase-a-putative-endogenous-antioxidant-defense-mechanism-during-cerebral-ischemia-reperfusion
#13
Yusuke Yamamoto, Kohkichi Hosoda, Taichiro Imahori, Jun Tanaka, Kazuya Matsuo, Tomoaki Nakai, Yasuhiro Irino, Masakazu Shinohara, Naoko Sato, Takashi Sasayama, Kazuhiro Tanaka, Hiroaki Nagashima, Masaaki Kohta, Eiji Kohmura
Molecular mechanism underlying ischemic stroke remains poorly understood. We previously reported glucose 6-phosphate dehydrogenase (G6PD) activity in pentose phosphate pathway (PPP) is activated via heat shock protein 27 (HSP27) phosphorylation at serine 85 (S85) by ataxia telangiectasia mutated (ATM) kinase during cerebral ischemia. This mechanism seems to be endogenous antioxidative system. To determine whether this system also works during reperfusion, we performed comparative metabolic analysis of reperfusion effect on metabolism in rat cortex using middle cerebral artery occlusion (MCAO)...
March 3, 2018: Brain Research
https://www.readbyqxmd.com/read/29505740/the-role-of-microrna-146a-in-regulating-the-expression-of-irak1-in-cerebral-ischemia-reperfusion-injury
#14
Bo Chu, Yadong Zhou, Heng Zhai, Lei Li, Li Sun, Yun Li
MicroRNA-146a (miR-146a) is reportedly implicated in the pathogenesis of ischemia/reperfusion (I/R) injury. Its role in the cerebral I/R injury is however unclear and requires further investigation. In this study, cerebral I/R injury was established in mice via middle cerebral artery occlusion (MCAO), and the expression of miR-146a was detected in the brain tissue via quantitative real-time PCR. We found that the expression of miR-146a was up-regulated. Furthermore, the endogenous miR-146a was antagonized by its specific inhibitor...
March 5, 2018: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/29497356/role-of-mtorc1-controlling-proteostasis-after-brain-ischemia
#15
REVIEW
Maria J Perez-Alvarez, Mario Villa Gonzalez, Irene Benito-Cuesta, Francisco G Wandosell
Intense efforts are being undertaken to understand the pathophysiological mechanisms triggered after brain ischemia and to develop effective pharmacological treatments. However, the underlying molecular mechanisms are complex and not completely understood. One of the main problems is the fact that the ischemic damage is time-dependent and ranges from negligible to massive, involving different cell types such as neurons, astrocytes, microglia, endothelial cells, and some blood-derived cells (neutrophils, lymphocytes, etc...
2018: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29493139/-protective-effects-of-ginkgo-terpene-lactones-meglumine-injection-on-focal-cerebral-ischemia-in-rats
#16
Yan-Ping Luo, Hong Zhang, Han-Fei Hu, Ze-Yu Cao, Xin-Zhuang Zhang, Liang Cao, Zhen-Zhong Wang, Wei Xiao
To investigate the protective effects of ginkgo diterpene lactone meglumine injection (GDLMI) on cerebral focal ischemia reperfusion injury induced by middle cerebral artery occlusion (MCAO) in rats, and explore its possible mechanism. One hundred and forty male SD rats were randomly divided into sham operation group, model group, ginkgo biloba extract injection (Ginaton, 1.0 mL•kg⁻¹) group, nimodipine (0.4 mg•kg⁻¹) group, and GDLMI (5.2, 2.6, 1.3 mg•kg⁻¹) groups; All of rats received corresponding drugs by tail vein injection 4 days before operation (normal saline in model group and sham operation group)...
December 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29484397/adenoviruses-mediated-rna-interference-targeting-cytosolic-phospholipase-a2%C3%AE-attenuates-focal-ischemic-brain-damage-in-mice
#17
Huijun Wu, Hui Liu, Fengtong Zuo, Lihua Zhang
Cerebral ischemia injury is a clinical, frequently occurring disease, which causes a heavy burden on society and families. It has been demonstrated that cytosolic phospholipase A2α (cPLA2α) is significant in neurological injury caused by ischemic brain injury, and inhibition of cPLA2α may reduce stroke injury. In the present study, the role of cPLA2α was investigated in a mouse model of middle cerebral artery occlusion and/or reperfusion (MCAO/R) using an effective cPLA2α inhibitor and adenoviruses‑mediated RNA interference...
February 15, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29484272/curcumin-protects-neural-cells-against-ischemic-injury-in-n2a-cells-and-mouse-brain-with-ischemic-stroke
#18
Cai-Jun Xie, Ai-Ping Gu, Jun Cai, Yi Wu, Rui-Cong Chen
Background and Purpose: Curcumin, a natural antioxidant isolated from Curcuma longa, has been reported to exert neuroprotective effect in animal models of ischemic stroke. However, the underlying mechanism is still not fully understood. The purpose of this study was to investigate the effect of curcumin treatment on neuronal apoptosis in the periinfarct cortex after cerebral ischemia/reperfusion (I/R) injury and in mouse N2a cells after oxygen-glucose deprivation/reoxygenation (OGD/R) injury and its underlying mechanism...
February 2018: Brain and Behavior
https://www.readbyqxmd.com/read/29481794/enriched-environment-promotes-post-stroke-neurogenesis-through-nf-%C3%AE%C2%BAb-mediated-secretion-of-il-17a-from-astrocytes
#19
Yujing Zhang, Dan Xu, Hong Qi, Yin Yuan, Hong Liu, Shanglong Yao, Shiying Yuan, Jiancheng Zhang
Enriched environment (EE) has been shown to promote post-stroke neurogenesis and functional recovery. However, the underlying molecular mechanisms remains poorly understood. Male C57BL/6 mice underwent 60-min middle cerebral artery occlusion (MCAO) followed by reperfusion, after which mice were housed in either standard environment (SE) or EE. We found that post-ischemic EE exhibited reduced protein level of nuclear factor κB (NF-κB)/p65 in cytoplasm and increased its expression correspondingly in nucleus at 28 days post-ischemia (dpi)...
February 23, 2018: Brain Research
https://www.readbyqxmd.com/read/29478968/microrna-210-promotes-accumulation-of-neural-precursor-cells-around-ischemic-foci-after-cerebral-ischemia-by-regulating-the-socs1-stat3-vegf-c-pathway
#20
Zhao-You Meng, Hua-Li Kang, Wei Duan, Jian Zheng, Qian-Ning Li, Zhu-Juan Zhou
BACKGROUND: Neural precursor cell (NPC) migration toward lesions is key for neurological functional recovery. The neovasculature plays an important role in guiding NPC migration. MicroRNA-210 (miR-210) promotes angiogenesis and neurogenesis in the subventricular zone and hippocampus after cerebral ischemia; however, whether miR-210 regulates NPC migration and the underlying mechanism is still unclear. This study investigated the role of miR-210 in NPC migration. METHODS AND RESULTS: Neovascularization and NPC accumulation was detected around ischemic foci in a mouse model of middle cerebral artery occlusion (MCAO) and reperfusion...
February 25, 2018: Journal of the American Heart Association
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