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mandibular distraction osteogenesis

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https://www.readbyqxmd.com/read/28208057/vertical-alveolar-distraction-osteogenesis-of-the-atrophic-posterior-mandible-before-dental-implant-insertion
#1
Adi Rachmiel, Dekel Shilo, Dror Aizenbud, Omri Emodi
PURPOSE: Augmentation of deficient mandibular posterior alveolar ridges poses a great challenge because of extensive bone deficiency and the presence of the inferior alveolar nerve. This study sets its focus on vertical alveolar distraction osteogenesis (ADO) at the posterior mandible before dental implant placement. MATERIALS AND METHODS: The study included 21 sites in 18 patients with severe mandibular posterior alveolar ridge deficiency. A trapezoidal osteotomy was performed, and an extraosseous alveolar distraction device was fixed and activated after a 4-day latency period at a rate of 0...
January 21, 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28203515/curvilinear-segmental-mandibular-reconstruction-utilizing-distraction-osteogenesis-and-early-open-callus-manipulation
#2
Alberto Rocha Pereira, Paulo Neves, José Rosa, Scott Bartlett
The authors present a new technique for reconstruction of large curvilinear mandibular defects with distraction osteogenesis and early open callus manipulation. In phase 1, transport disks are created from mandibular bone and distracted across the entire length of the defect, without the restriction from a mandible plate fixation. This allows for full-length distraction until enough regenerate is obtained to reconstruct the defect without the need for additional bone grafts. Taking advantage of the soft moldable regenerate, the second and final operative procedure allows for the manipulation, repositioning, and fixation of the transported segments in the ideal position creating perfect tridimensional form and symmetry of the mandible arch...
January 2017: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/28198643/the-role-of-curvilinear-distraction-system-in-pediatric-obstructive-sleep-apnea-a-case-report
#3
David Serrano Faustino Ângelo, Bruno Rosa, Rogério Santos, Carlos Diogo Matos
OBJECTIVE: The authors present a case of obstructive sleep apnea associated with severe mandibular micrognathia treated by mandibular bone distraction with curvilinear system planned under computer assistance. CLINICAL PRESENTATION: A 15-year-old child with limited compliance to continuous positive airway therapy was referred to the authors' department. Observation revealed severe mandibular micrognathia as the major cause for obstructive sleep apnea syndrome. The first polysomnography study revealed 14 obstructive apneas, 16 obstructive hypopneas, and 4...
February 15, 2017: Cranio: the Journal of Craniomandibular Practice
https://www.readbyqxmd.com/read/28169263/comparison-of-soft-tissue-changes-in-simultaneous-maxillomandibular-distraction-with-mandibular-distraction-with-second-stage-maxillary-osteotomy
#4
S M Balaji, Preetha Balaji
BACKGROUND: The purpose of this study was to compare the frontal lip cant changes in common facial asymmetry (FA) cases after simultaneous maxillomandibular distraction osteogenesis (DO) and mandibular DO with maxillary orthognathic surgery. MATERIALS AND METHODS: Retrospective analysis of FA cases at tertiary craniofacial referral was performed. Patients of either gender with all medical imaging records and pre- and post-operative (1 year) facial photographs in natural head position were included in the study...
November 2016: Indian Journal of Dental Research: Official Publication of Indian Society for Dental Research
https://www.readbyqxmd.com/read/28153168/transport-distraction-osteogenesis-combined-with-orthodontic-treatment-in-a-patient-with-unilateral-temporomandibular-joint-ankylosis
#5
Seo-Yeon Jung, Jung-Hyun Park, Hyung-Sik Park, Hyoung-Seon Baik
Temporomandibular joint ankylosis manifests a range of clinical characteristics dependent upon the age of onset, the affected side, and the severity. When it occurs during development, mandibular growth is affected, resulting in severe retrusion or asymmetry as well as limitation of mandibular movements. Progressive asymmetric mandibular growth in unilateral ankylosis causes canting of the occlusal plane. In this case report, we present a successful temporomandibular joint reconstruction using transport distraction osteogenesis combined with camouflage orthodontic treatment for occlusal canting correction of a patient with unilateral temporomandibular joint ankylosis and severe facial asymmetry...
February 2017: American Journal of Orthodontics and Dentofacial Orthopedics
https://www.readbyqxmd.com/read/28134640/rehabilitation-of-the-work-accident-related-traumatic-mandible-with-iliac-free-flap-distraction-osteogenesis-and-dental-implants
#6
Yavuz Findik, Timuçin Baykul, Mustafa Asim Aydin, Selman Altuntaş, Zeynep Başağaoğlu Demirekin
Mandibular bone defects due to extensive trauma impair occlusion and affect the aesthetics of facial contouring, making it difficult to obtain a satisfactory outcome. Distraction osteogenesis and free flap is an effective and aesthetic treatment option for rehabilating these defects. In this clinical report, the authors present rehabilitation of a wide mandibular traumatic defect due to a work-related accident with iliac free flap, distraction osteogenesis, and dental implants.
January 27, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28126687/the-mechanically-activated-p38-mmp-2-signaling-pathway-promotes-bone-marrow-mesenchymal-stem-cell-migration-in-rats
#7
Zihui Yang, Baolei Wu, Sen Jia, Yinghua Zhao, Rui Hou, Xiaochang Liu, Xinge Wang, Litong Chen, Xinjie Yang, Delin Lei, Lei Wang
OBJECTIVE: The aim of the present study was to investigate the effect of static strain on bone marrow mesenchymal stem cell (BMMSC) migration and whether the p38/matrix metalloproteinase-2 (MMP-2) axis plays a role in induction of BMMSC migration under mechanical strain. DESIGN: Both in vivo and in vitro investigations were performed. Twelve adult male Sprague-Dawley rats were randomly divided into 2 groups (n=6 per group). Rats in the experimental group underwent right mandibular distraction osteogenesis, whereas rats in the control group were subjected to osteotomy in the mandible without distraction...
January 22, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/28110408/gingival-recessions-of-lower-incisors-after-proclination-by-orthodontics-alone-or-in-combination-with-anterior-mandibular-alveolar-process-distraction-osteogenesis
#8
Gregory S Antonarakis, Christof Urs Joss, Albino Triaca, Anne Marie Kuijpers-Jagtman, Stavros Kiliaridis
OBJECTIVES: The aim of this study was to longitudinally compare periodontal conditions in consecutive patients who had orthodontic treatment with proclination of lower incisors either by orthodontics alone or in combination with anterior mandibular alveolar process distraction osteogenesis (DO). MATERIALS AND METHODS: Nineteen patients had orthodontic treatment with DO, 18 with extraction of lower premolars (Ex), and 18 without extractions (Nonex). Lateral cephalograms were used to evaluate lower incisor proclination, while study casts and intraoral photographs were used to evaluate labial and lingual gingival recessions before (T1) and at an average of 4...
January 21, 2017: Clinical Oral Investigations
https://www.readbyqxmd.com/read/28106628/neonatal-micrognathia-national-trends-in-early-mandibular-surgery
#9
Hillary E Jenny, Benjamin B Massenburg, E Hope Weissler, Peter J Taub
BACKGROUND: Micrognathia is a congenital anomaly that may pose breathing and feeding limitations in newborns, sometimes necessitating invasive management. The present study aims to identify the complications associated with receiving mandibular surgery during the birth stay in order to better predict which patients may benefit from early surgical intervention. METHODS: A retrospective cohort study was performed using the 2000 to 2012 kids' inpatient databases. We included all live newborn infants born in the hospital through vaginal delivery or caesarean section...
March 2017: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/28053912/management-of-obstructive-sleep-apnea-in-a-treacher-collins-syndrome-patient-using-distraction-osteogenesis-of-the-mandible
#10
İbrahim Damlar, Ahmet Altan, Berk Turgay, Soydan Kiliç
In this study, we present the surgical treatment of obstructive sleep apnea in a child with Treacher Collins syndrome. A 10-year-old girl with a past history of Treacher Collins syndrome presented to our clinic with her parents for respiratory distress and insomnia. The patient was referred to a sleep laboratory where she was diagnosed with obstructive sleep apnea, which was a consequence of her Treacher Collins syndrome. The patient underwent mandibular distraction osteogenesis under general anesthesia. The mandible was expanded by 15 mm using internal bilateral distractors...
December 2016: Journal of the Korean Association of Oral and Maxillofacial Surgeons
https://www.readbyqxmd.com/read/28027240/gastrostomy-placement-rates-in-infants-with-pierre-robin-sequence-a-comparison-of-tongue-lip-adhesion-and-mandibular-distraction-osteogenesis
#11
Srinivas M Susarla, Gerhard S Mundinger, Christopher C Chang, Edward W Swanson, Denver Lough, S Alex Rottgers, Richard J Redett, Anand R Kumar
BACKGROUND: This study was conducted to compare the gastrostomy rates in infants with Pierre Robin sequence treated with tongue-lip adhesion or mandibular distraction osteogenesis. METHODS: This was a retrospective study of symptomatic plastic and reconstructive surgery patients treated over an 8-year period. The primary predictor variable was surgical intervention (tongue-lip adhesion or distraction osteogenesis). Secondary predictor variables were categorized as demographic and clinical factors...
January 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28027184/piezosurgery-an-asset-in-treatment-of-pierre-robin-sequence
#12
Divya Singh, Pushkar Gadre, Kiran Gadre, Shandilya Ramanojam
Pierre Robin sequence (formerly a syndrome) is named after the French stomatologist who, in 1923 and 1934, described the problems associated with micrognathia in newborn. It comprises mandibular micrognathia, U-shaped cleft palate, and glossoptosis. The typical symptoms are hypoxaemia, noisy breathing, snoring, stridor, cyanosis, bradycardia, feeding difficulties, and failure to thrive. Distraction osteogenesis has recently been considered as a surgical option for early intervention to lengthen the mandible and relieve respiratory problems...
December 23, 2016: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28024774/three-dimensional-virtual-surgery-simulation-assisted-asymmetric-bilateral-mandibular-distraction-osteogenesis-for-a-patient-with-bilateral-condylar-fractures
#13
Myung-Jin Kim, Jihee Seo, Do-Keun Kim, Seung-Hak Baek
INTRODUCTION: Our objective was to report a patient treated with 3-dimensional virtual-surgery simulation-assisted asymmetric bilateral mandibular distraction osteogenesis. METHODS: A boy (age, 9.5 years) had mandibular hypoplasia and facial asymmetry, induced by bilateral condylar fractures at 4 years of age. The asymmetric bilateral mandibular distraction osteogenesis was planned to correct facial asymmetry and mandibular hypoplasia. The 3-dimensional virtual-surgery simulation results were 11 mm of horizontal distraction on the right side and 4...
January 2017: American Journal of Orthodontics and Dentofacial Orthopedics
https://www.readbyqxmd.com/read/27875515/reconstruction-of-congenital-mandibular-hypoplasia-with-microvascular-free-fibula-flaps-in-the-pediatric-population-a-paradigm-shift
#14
Emily C Cleveland, Jamie Zampell, Tomer Avraham, Z-Hye Lee, David Hirsch, Jamie P Levine
BACKGROUND: The microvascular free fibula flap has become the gold standard for reconstruction of complex mandibular defects since its description by Hidalgo in 1989. Prior studies have demonstrated its safety and efficacy in the pediatric population. However, this reconstructive method is often used only as a last resort for correction of congenital mandibular hypoplasia, after failure of bone grafting and distraction osteogenesis. The authors describe our experience using this technique, facilitated by virtual planning and prefabricated cutting jigs, for children with severe congenital mandibular hypoplasia...
January 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/27833343/distraction-osteogenesis-for-management-of-severe-osa-in-pierre-robin-sequence-an-approach-to-elude-tracheostomy-in-infants
#15
N K Sahoo, I D Roy, Shamsher Dalal, Amit Bhandari
BACKGROUND: Severe obstructive sleep apnoea (OSA) is a life threatening condition associated with Pierre Robin sequence (PRS) due to mandibular micrognathia and glossoptosis. Often these patients require tracheostomy at an early age which has high morbidity. Distraction osteogenesis (DO) is an accepted method of treatment for patients with hypoplastic mandible to achieve mandibular lengthening without need for a bone graft. It has also been used in respiratory distressed neonates and infants to avoid tracheostomy...
December 2016: Journal of Maxillofacial and Oral Surgery
https://www.readbyqxmd.com/read/27833342/hard-and-soft-tissue-changes-following-maxillary-distraction-osteogenesis-and-mandibular-setback-with-bilateral-sagittal-split-osteotomy
#16
Shilpa S Bawane, Neelam N Andrade
AIMS OF THIS STUDY: (1) To highlight the role of intraoral submerged device in distraction osteogenesis (DO) of patients requiring two jaw surgeries for the correction of severe developmental maxillary hypoplasia (MH) and mandibular prognathism (MP) (2) To analyse the hard and soft tissue changes following maxillary DO and mandibular setback with bilateral sagittal split osteotomy (BSSO) in patients with severe MH and MP requiring two jaw surgeries. MATERIALS AND METHODS: During the period Jan 2004 to Dec 2006, five patients with severe developmental MH along with MP were treated...
December 2016: Journal of Maxillofacial and Oral Surgery
https://www.readbyqxmd.com/read/27779806/role-of-parathyroid-hormone-in-regeneration-of-irradiated-bone-in-a-murine-model-of-mandibular-distraction-osteogenesis
#17
Stephen Y Kang, Sagar S Deshpande, Alexander R Zheutlin, Alexis Donneys, Jose J Rodriguez, Noah S Nelson, Peter A Felice, Douglas B Chepeha, Steven R Buchman
BACKGROUND: The purpose of this study was to measure the histologic and histomorphometric effects of parathyroid hormone (PTH) treatment on irradiated bone undergoing distraction osteogenesis (DO). METHODS: Thirty-four rats were divided into 3 groups. The control group underwent DO and the radiation control group underwent radiotherapy (RT) before DO. The PTH group underwent RT and received PTH during DO. Quantitative histology and histomorphometry were performed...
October 25, 2016: Head & Neck
https://www.readbyqxmd.com/read/27766028/targeting-p38-pathway-regulates-bony-formation-via-msc-recruitment-during-mandibular-distraction-osteogenesis-in-rats
#18
Zi-Hui Yang, Bao-Lei Wu, Chen Ye, Sen Jia, Xin-Jie Yang, Rui Hou, De-Lin Lei, Lei Wang
Distraction osteogenesis (DO) is a widely used self-tissue engineering. However, complications and discomfort due to the long treatment period are still the bottleneck of DO. Novel strategies to accelerate bone formation in DO are still needed. P38 is capable of regulating the osteogenic differentiation of both mesenchymal stem cells (MSCs) and osteoblasts, which are crucial to bone regeneration. However, it is not clear whether targeting p38 could regulate bony formation in DO. The purpose of the current work was to investigate the effects of local application of either p38 agonist anisomycin or p38 inhibitor SB203580 in a rat model of DO...
2016: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/27752211/early-mandibular-distraction-to-relieve-robin-severe-airway-obstruction-in-two-siblings-with-lymphedema-distichiasis-syndrome
#19
Paola Papoff, Marco Castori, Lucia Manganaro, Fabio Midulla, Corrado Moretti, Piero Cascone
Although micrognathia and cleft palate have been reported in patients with Lymphedema-distichiasis syndrome (LDS), the classic Robin sequence with glossoptosis and airway obstruction has not been previously described in patients with genetically confirmed LDS. Here we report on two female siblings with LDS confirmed by a FOXC2 mutation who presented at birth with severe airway obstruction related to Robin sequence. Respiratory obstruction was successfully managed by early distraction osteogenesis. Our report highlights the unusual occurrence of Robin sequence in LDS patients and advises distraction osteogenesis to resolve breathing problems in LDS patients who present with Robin related severe airway obstruction...
September 2016: Journal of Maxillofacial and Oral Surgery
https://www.readbyqxmd.com/read/27727105/ckip-1-silencing-promotes-new-bone-formation-in-rat-mandibular-distraction-osteogenesis
#20
Zi-Chao Zhou, Lei Che, Liang Kong, De-Lin Lei, Rui Liu, Xin-Jie Yang
OBJECTIVE: This study investigated the effects and possible molecular mechanism of casein kinase-2 interacting protein-1 (CKIP-1) silencing on bone regeneration during rat mandibular distraction osteogenesis (DO). STUDY DESIGN: CKIP-1 silencing by chitosan/si-CKIP-1 was employed and analyzed both in rat mandibular DO models in vivo and in cultured rat mandible bone marrow stromal cells (BMSCs) in vitro. RESULTS: Gross observation, micro-computed tomography analysis, and hematoxylin and eosin (H&E) staining revealed that new bone formation in the distraction gap of the chitosan/si-CKIP-treated group was better compared with the chitosan/si-NC and phosphate buffered saline-treated groups in both quantity and quality...
January 2017: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
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