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https://www.readbyqxmd.com/read/29206881/deletion-of-lynx1-reduces-the-function-of-%C3%AE-6-nicotinic-receptors
#1
Rell L Parker, Heidi C O'Neill, Beverley M Henley, Charles R Wageman, Ryan M Drenan, Michael J Marks, Julie M Miwa, Sharon R Grady, Henry A Lester
The α6 nicotinic acetylcholine receptor (nAChR) subunit is an attractive drug target for treating nicotine addiction because it is present at limited sites in the brain including the reward pathway. Lynx1 modulates several nAChR subtypes; lynx1-nAChR interaction sites could possibly provide drug targets. We found that dopaminergic cells from the substantia nigra pars compacta (SNc) express lynx1 mRNA transcripts and, as assessed by co-immunoprecipitation, α6 receptors form stable complexes with lynx1 protein, although co-transfection with lynx1 did not affect nicotine-induced currents from cell lines transfected with α6 and β2...
2017: PloS One
https://www.readbyqxmd.com/read/29176575/phosphorylation-of-lamp2a-by-p38-mapk-couples-er-stress-to-chaperone-mediated-autophagy
#2
Wenming Li, Jinqiu Zhu, Juan Dou, Hua She, Kai Tao, Haidong Xu, Qian Yang, Zixu Mao
Endoplasmic reticulum (ER) and lysosomes coordinate a network of key cellular processes including unfolded protein response (UPR) and autophagy in response to stress. How ER stress is signaled to lysosomes remains elusive. Here we find that ER disturbance activates chaperone-mediated autophagy (CMA). ER stressors lead to a PERK-dependent activation and recruitment of MKK4 to lysosomes, activating p38 MAPK at lysosomes. Lysosomal p38 MAPK directly phosphorylates the CMA receptor LAMP2A at T211 and T213, which causes its membrane accumulation and active conformational change, activating CMA...
November 24, 2017: Nature Communications
https://www.readbyqxmd.com/read/29174294/the-kv7-kcnq-channel-blocker-xe991-protects-nigral-dopaminergic-neurons-in-the-6-hydroxydopamine-rat-model-of-parkinson-s-disease
#3
Haixia Liu, Lu Jia, Xiaoyan Chen, Limin Shi, Junxia Xie
The excitability of dopaminergic neurons in the substantia nigra pars compacta (SNc) that supply the striatum with dopamine (DA) determines the function of the nigrostriatal system for motor coordination. We previously showed that 4-pyridinylmethyl-9(10H)-anthracenone (XE991), a specific blocker of Kv7/KCNQ channels, enhanced the excitability of nigral DA neurons and resulted in attenuation of haloperidol-induced catalepsy in a Parkinson's disease (PD) rat model. However, whether XE991 exhibits neuroprotective effects towards DA neuron degeneration remains unknown...
November 21, 2017: Brain Research Bulletin
https://www.readbyqxmd.com/read/29137945/the-effects-of-local-microinjection-of-selective-dopamine-d1-and-d2-receptor-agonists-and-antagonists-into-the-dorsal-raphe-nucleus-on-sleep-and-wakefulness-in-the-rat
#4
Jaime M Monti, Héctor Jantos
The effects of the dopamine (DA) D1 and D2 receptor agonists SKF38393, bromocriptine and quinpirole, respectively, on spontaneous sleep were analyzed in adult rats prepared for chronic sleep recordings. Local administration of the DAergic agonists into the dorsal raphe nucleus (DRN) during the light phase of the light-dark cycle induced a significant reduction of rapid-eye movement sleep (REMS) and the number of REM periods. Additionally, bromocriptine and quinpirole significantly increased wakefulness (W)...
November 11, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/29133763/effects-of-melatonin-levels-on-neurotoxicity-of-the-medial-prefrontal-cortex-in-a-rat-model-of-parkinson-s-disease
#5
Yan Li, Shu-Mei Wang, Lei Guo, Jian Zhu, Ying Wang, Lei Li, Yan-Xin Zhao
BACKGROUND: Damage of the medial prefrontal cortex (mPFC) results in similar characteristics to the cognitive deficiency seen with the progress of Parkinson's disease (PD). Since the course of mPFC damage is still unclear, our study aimed to investigate the effects of melatonin (MT) on neurotoxicity in the mPFC of a rat model of PD. METHODS: One hundred and fifty-four normal, male Wistar rats were randomly divided into the following five groups: normal + normal saline (NS), normal + 6-hydroxydopamine (6-OHDA), sham pinealectomy (PX) + 6-OHDA, PX + 6-OHDA, and MT + 6-OHDA...
November 20, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/29126116/c-621-15-w-and-others-v-sanofi-pasteur-an-example-of-judicial-distortion-and-indifference-to-science
#6
Laura R Smillie, Mark R Eccleston-Turner, Sarah L Cooper
This case commentary examines the CJEU's recent decision in C-621/15 W and Others v Sanofi Pasteur MSD SNC [2017] ECR I. This commentary critically examines the decision through the lens of the cultural conflict between law and science. We argue that the CJEU's decision reflects both a distortion of scientific knowledge and an improper indifference to the legitimate methods by which scientific knowledge is generated in the context of vaccines. These judicial approaches may, the authors argue, inadvertently fuel the vaccine scepticism that is growing across the developed world, and in particular in Europe...
November 8, 2017: Medical Law Review
https://www.readbyqxmd.com/read/29114957/sinonasal-cancer-in-the-italian-national-surveillance-system-epidemiology-occupation-and-public-health-implications
#7
Alessandra Binazzi, Marisa Corfiati, Davide Di Marzio, Anna M Cacciatore, Jana Zajacovà, Carolina Mensi, Paolo Galli, Lucia Miligi, Roberto Calisti, Elisa Romeo, Alessandro Franchi, Alessandro Marinaccio
BACKGROUND: Sinonasal cancer (SNC) is a rare tumor with predominant occupational etiology associated with exposures to specific carcinogens. The aim of this study is to describe SNC cases recorded in Italy in the period 2000-2016. METHODS: Clinical information, occupational history, and lifestyle habits of SNC cases collected in the Italian Sinonasal Cancer Register were examined. Age-standardized rates were estimated. RESULTS: Overall, 1529 cases were recorded...
November 7, 2017: American Journal of Industrial Medicine
https://www.readbyqxmd.com/read/29114130/phylogenetic-study-based-on-28s-rrna-gene-sequencing-of-wuchereria-bancrofti-isolated-from-the-filaria-endemic-areas-of-bankura-district-west-bengal-india
#8
Soumendranath Chatterjee, Swapan Kumar Rudra, Syed Afrin Azmi, Raktima Bandyopadhyay
Lymphatic filariasis is one of the major public health concern in India, and Bankura district of West Bengal is one of the main filaria prone area of the country. Wuchereria bancrofti is the causative organism and Culex quinquefasciatus is the main vector of lymphatic filariasis in India. In the present study, infection and infectivity rate of filarial vector C. quinquefasciatus were determined. The molecular characterization, DNA fingerprinting and phylogenetic analysis of W. bancrofti was done. In the study area, overall vector infection and infectivity rates were 4...
December 2017: Journal of Parasitic Diseases: Official Organ of the Indian Society for Parasitology
https://www.readbyqxmd.com/read/29111022/association-of-freezing-of-gait-with-nigral-iron-accumulation-in-patients-with-parkinson-s-disease
#9
Rajini M Naduthota, Arush Arun Honnedevasthana, Abhishek Lenka, Jitender Saini, Sairam Geethanath, Rose Dawn Bharath, Rita Christopher, Ravi Yadav, Arun Kumar Gupta, Pramod Kumar Pal
BACKGROUND AND PURPOSE: The objective of this work was to investigate whether patients with and without freezing of gait (FOG) in Parkinson's disease (PD) have differences in iron accumulation in substantia nigra using R2* relaxometry. MATERIALS AND METHODS: This study included seventeen PD patients with FOG [FOG (+)], equal number of age and gender matched patients without FOG [FOG (-)] and 34 healthy controls (HC). T2* images were obtained from a 3-Tesla MRI system using multi-echo sequence...
November 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/29107519/direct-dopaminergic-projections-from-the-snc-modulate-visuomotor-transformation-in-the-lamprey-tectum
#10
Juan Pérez-Fernández, Andreas A Kardamakis, Daichi G Suzuki, Brita Robertson, Sten Grillner
Dopamine neurons in the SNc play a pivotal role in modulating motor behavior via striatum. Here, we show that the same dopamine neuron that targets striatum also sends a direct branch to the optic tectum (superior colliculus). Whenever SNc neurons are activated, both targets will therefore be affected. Visual stimuli (looming or bars) activate the dopamine neurons coding saliency and also elicit distinct motor responses mediated via tectum (eye, orienting or evasive), which are modulated by the dopamine input...
November 15, 2017: Neuron
https://www.readbyqxmd.com/read/29107062/the-anti-aging-protein-klotho-alleviates-injury-of-nigrostriatal-dopaminergic-pathway-in-6-hydroxydopamine-rat-model-of-parkinson-s-disease-involvement-of-pka-camkii-creb-signaling
#11
Tourandokht Baluchnejadmojarad, Seyed-Mohammad Eftekhari, Nida Jamali-Raeufy, Sobhan Haghani, Hossein Zeinali, Mehrdad Roghani
Parkinson's disease (PD) is a prevalent movement disorder in the elderly. PD is hallmarked with progressive deterioration of mesencephalic dopaminergic neurons and development of debilitating motor and non-motor clinical symptoms. Klotho protein is the product of an aging-suppressor gene that its overexpression could protect neurons against oxidative injury. This study was undertaken to explore whether exogenous klotho could alleviate injury of nigrostriatal dopaminergic pathway in 6-hydroxydopamine (6-OHDA) rat model of PD...
October 31, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/29105780/structural-thermal-and-morphological-characteristics-of-cassava-amylodextrins
#12
Mariana Souza Costa, Diogo Paschoalini Volanti, Maria Victória Eiras Grossmann, Célia Maria Landi Franco
BACKGROUND: Amylodextrins from cassava starch were obtained by acid hydrolysis and their structural, thermal, and morphological characteristics were evaluated and compared to those from potato and corn amylodextrins. RESULTS: Cassava starch was the most susceptible to hydrolysis due to imperfections in its crystalline structure. The crystalline patterns of amylodextrins kept unchanged and crystallinity and peak temperature increased with hydrolysis time, while thermal degradation temperature decreased, independently of treatment time and starch source...
November 6, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/29082377/sub-classification-of-breast-masses-by-fine-needle-aspiration-cytology
#13
C I Madubogwu, C O Ukah, Snc Anyanwu, G U Chianakwana, I V Onyiaorah, Dcd Anyiam
OBJECTIVE: The aim of this study is to evaluate the accuracy of sub-classification of breast diseases using Fine Needle Aspiration cytology (FNAC). MATERIALS AND METHODS: A one-year prospective study of 180 consecutive patients with palpable breast lesions who underwent FNAC and subsequently open surgical biopsy for histological confirmation. FNAC was used to sub-classify breast lesions and then correlated with histological diagnosis. RESULTS: A total of 180 patients were enrolled into the study but only 110 patients with histology report were used for test validity...
October 2017: European Journal of Breast Health
https://www.readbyqxmd.com/read/29057540/differential-actions-of-amp-kinase-on-k-atp-currents-in-ventral-tegmental-area-and-substantia-nigra-zona-compacta-neurons
#14
Yan-Na Wu, Ke-Zhong Shen, Steven W Johnson
ATP-sensitive K(+) (K-ATP) channels play significant roles in regulating the excitability of dopamine neurons in the substantia nigra zona compacta (SNC). We showed previously that K-ATP channel function is up-regulated by AMP-activated protein kinase (AMPK). The current study extended these studies to the neurons adjacent to the SNC in the ventral tegmental area (VTA). Using patch pipettes to record whole-cell currents in slices of rat midbrain, we found that the AMPK activator A769662 increased the amplitude of currents evoked by the K-ATP channel opener diazoxide in presumed dopamine-containing VTA neurons...
October 23, 2017: European Journal of Neuroscience
https://www.readbyqxmd.com/read/29056464/a-population-based-comparison-of-european-and-north-american-sinonasal-cancer-survival
#15
Aykut A Unsal, Suat Kılıç, Pariket M Dubal, Soly Baredes, Jean Anderson Eloy
OBJECTIVE: Sinonasal cancers (SNC) are rare, thus limiting previous prognostic studies on a multinational level. The aim of this study is to utilize two population-based datasets to compare prognoses for SNC between the United States (US) and Europe. METHODS: The European Cancer Registry (EUROCARE) database and the United States National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER) database were searched to identify survival of patients diagnosed with SNC between 1990 and 2007...
October 19, 2017: Auris, Nasus, Larynx
https://www.readbyqxmd.com/read/29052678/oxidant-free-synthesis-of-benzimidazoles-from-alcohols-and-aromatic-diamines-catalysed-by-new-ru-ii-pns-o-pincer-complexes
#16
Qi Luo, Zengjin Dai, Hengjiang Cong, Renjie Li, Tianyou Peng, Jing Zhang
Benzimidazoles are chemically and pharmaceutically important, and an environmentally benign synthetic method based on acceptorless dehydrogenative condensation of primary alcohols and benzene-1,2-diamine is developed in this work. Three Ru(ii) hydride complexes [RuHCl(CO)(PNS(O))] (containing two isomers 1a and 1b) and [RuHCl(CO)(PPh3)(SNC(NHC))]PF6 (2) based on two new quinoline-based ligands 2-(diphenylphosphanylmethyl)-8-phenylsulfinylquinoline (PNS(O)) and 1-mesityl-3-(8-phenylthioquinolyl-2-methyl)-2-imidazole carbene (SNC(NHC)) are prepared and fully characterized...
November 7, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29050969/a-novel-selective-mao-b-inhibitor-with-neuroprotective-and-anti-parkinsonian-properties
#17
Hugh H Chan, Man Kit Tse, Saravana Kumar, Lang Zhuo
We previously reported that 1,3-bisbenzylimidazolium (DBZIM) bromide was neuroprotective for the dopaminergic system in Parkinson's disease (PD) models of rodent, however the underlying mechanism was unclear. We currently further confirmed that DBZIM ameliorated the Parkinsonian motor deficit and protected the nigrostriatal tract from the neurotoxicity of 1-methyl-4-(2'-methylphenyl)-1,2,3,6-tetrahydropyridine (2'-CH3-MPTP) in C57Bl/6 mice. The dopaminergic degeneration in the substantia nigra par compacta (SNc) and striatum was analyzed by immunohistochemistry while the monoamine oxidase B (MAO-B) inhibition effect of DBZIM was determined by enzyme kinetics...
October 17, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29037791/effect-of-optogenetic-modulation-on-entopeduncular-input-affects-thalamic-discharge-and-behavior-in-an-aav2-%C3%AE-synuclein-induced-hemiparkinson-rat-model
#18
Hyeong Cheol Moon, So Yoon Won, Eung Gook Kim, Hyong Kyu Kim, Chul Bum Cho, Young Seok Park
OBJECTIVE: Neuromodulation of the globus pallidus internus(GPi) alleviates Parkinson's disease symptoms. The primate GPi is homologous to the rat entopeduncular nucleus (EP). The aim of the present study was to determine if optogenetic modulation of the EP could alter parkinsonian behavior or thalamic discharge in a hemiparkinson rat model. METHODS: We injected an adeno-associated virus type-2 expressing α-synuclein (AAV2-α-syn) into the substantia nigra pars compacta (SNc) of the right hemisphere and confirmed parkinsonian behavior using an amphetamine-induced rotation test...
October 14, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/29037497/comparative-toxicities-of-silver-nitrate-silver-nanocolloids-and-silver-chloro-complexes-to-japanese-medaka-embryos-and-later-effects-on-population-growth-rate
#19
Chisato Kataoka, Yumie Kato, Tadashi Ariyoshi, Masaki Takasu, Takahito Narazaki, Seiji Nagasaka, Haruki Tatsuta, Shosaku Kashiwada
Fish embryo toxicology is important because embryos are more susceptible than adults to toxicants. In addition, the aquatic toxicity of chemicals depends on water quality. We examined the toxicities to medaka embryos of three types of silver-AgNO3, silver nanocolloids (SNCs), and silver ions from silver nanoparticle plates (SNPPs)-under three pH conditions (4.0, 7.0, and 9.0) in embryo-rearing medium (ERM) or ultrapure water. Furthermore, we tested the later-life-stage effects of SNCs on medaka and their population growth...
October 13, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/29025968/activation-of-ampk-mtorc1-mediated-autophagy-by-metformin-reverses-clk1-deficiency-sensitized-dopaminergic-neuronal-death
#20
Qiuting Yan, Chaojun Han, Guanghui Wang, John L Waddington, Longtai Zheng, Xuechu Zhen
The autophagy-lysosome pathway (ALP) plays a critical role in the pathology of Parkinson's disease (PD). Clk1 (coq7) is a mitochondrial hydroxylase that is essential for coenzyme Q (ubiquinone) biosynthesis. We have reported previously that Clk1 regulates microglia activation via modulating microglia metabolic reprogramming, which contributes to dopaminergic neuronal survival. This study explores the direct effect of Clk1 on dopaminergic neuronal survival. We demonstrate that Clk1 deficiency inhibited dopaminergic neuronal autophagy in cultured MN9D dopaminergic neurons and in the substantia nigra pars compacta of Clk+/- mutant mice and consequently sensitized dopaminergic neuron damage and behavioral defects...
December 2017: Molecular Pharmacology
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