keyword
MENU ▼
Read by QxMD icon Read
search

snc

keyword
https://www.readbyqxmd.com/read/28088038/evidence-of-functional-duplicity-of-nestin-expression-in-the-adult-mouse-midbrain
#1
Parisa Farzanehfar, Shi Sheng Lu, Anupa Dey, Dharshani Musiienko, Hamzah Baagil, Malcolm K Horne, Tim D Aumann
Whether or not neurogenesis occurs in the adult substantia nigra pars compacta (SNc) is an important question relevant for developing better treatments for the motor symptoms of Parkinson's disease (PD). Although controversial, it is generally believed that dividing cells here remain undifferentiated or differentiate into glia, not neurons. However, there is a suggestion that Nestin-expressing neural precursor cells (NPCs) in the adult SNc have a propensity to differentiate into neurons, which we sought to confirm in the present study...
January 5, 2017: Stem Cell Research
https://www.readbyqxmd.com/read/28070736/genome-wide-analysis-of-mirnas-and-tasi-rnas-in-zea-mays-in-response-to-phosphate-deficiency
#2
Saurabh Gupta, Manju Kumari, Himansu Kumar, Pritish Kumar Varadwaj
Globally important cereal crop maize provides important nutritions and starch in dietary foods. Low phosphate (LPi) availability in the soil frequently limits the maize quality and yield across the world. Small non-coding RNAs (Snc-RNAs) play crucial roles in growth and adaptation of plants to the environment. Snc-RNAs like microRNAs (miRs) and trans-acting small interfering RNAs (Tasi-Rs) play important functions in posttranscriptional regulation of gene expression, which controls plant development, reproduction, and biotic/abiotic stress responses...
January 9, 2017: Functional & Integrative Genomics
https://www.readbyqxmd.com/read/28048656/su-f-t-301-planar-dose-pass-rate-inflation-due-to-the-mapcheck-measurement-uncertainty-function
#3
D Bailey, J Spaans, L Kumaraswamy, M Podgorsak
PURPOSE: To quantify the effect of the Measurement Uncertainty function on planar dosimetry pass rates, as analyzed with Sun Nuclear Corporation analytic software ("MapCHECK" or "SNC Patient"). This optional function is toggled on by default upon software installation, and automatically increases the user-defined dose percent difference (%Diff) tolerance for each planar dose comparison. METHODS: Dose planes from 109 IMRT fields and 40 VMAT arcs were measured with the MapCHECK 2 diode array, and compared to calculated planes from a commercial treatment planning system...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047288/su-f-t-310-does-a-head-mounted-ionization-chamber-detect-imrt-errors
#4
S Wegener, B Herzog, O Sauer
PURPOSE: The conventional plan verification strategy is delivering a plan to a QA-phantom before the first treatment. Monitoring each fraction of the patient treatment in real-time would improve patient safety. We evaluated how well a new detector, the IQM (iRT Systems, Germany), is capable of detecting errors we induced into IMRT plans of three different treatment regions. Results were compared to an established phantom. METHODS: Clinical plans of a brain, prostate and head-and-neck patient were modified in the Pinnacle planning system, such that they resulted in either several percent lower prescribed doses to the target volume or several percent higher doses to relevant organs at risk...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047219/su-f-t-443-quantification-of-dosimetric-effects-of-dental-metallic-implant-on-vmat-plans
#5
C Lin, Y Feng, Z Huang, W Jiang
PURPOSE: To evaluate the dosimetric impact of metallic implant that correlates with the size of targets and metallic implants and distance in between on volumetric-modulated arc therapy (VMAT) plans for head and neck (H&N) cancer patients with dental metallic implant. METHODS: CT images of H&N cancer patients with dental metallic implant were used. Target volumes with different sizes and locations were contoured. Metal artifact regions excluding surrounding critical organs were outlined and assigned with CT numbers close to water (0HU)...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047174/su-f-t-490-separating-effects-influencing-detector-response-in-small-mv-photon-fields
#6
S Wegener, O Sauer
PURPOSE: Different detector properties influence their responses especially in field sizes below the lateral electron range. Due to the finite active volume, the detector density and electron perturbation at other structural parts, the response factor is in general field size dependent. We aimed to visualize and separate the main effects contributing to detector behavior for a variety of detector types. This was achieved in an experimental setup, shielding the field center. Thus, effects caused by scattered radiation could be examined separately...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046616/su-f-t-311-comparison-of-measurements-from-two-diode-array-qa-devices-to-deep-point-dose-measurements-with-two-treatment-planning-model-settings-for-brain-vmat-srt-patient-specific-qa
#7
B Weethee, J Cheung, A Perez-Andujar, A Sudhyadhom, J Chen
PURPOSE: To investigate the sensitivity of traditional gamma-index-based analysis using diode arrays to detect significant dosimetric errors in patientspecific measurements for VMAT brain SRT plans. METHODS: Quality assurance measurements were performed using an ion chamber and two different diode array devices for four brain SRT treatment plans. All cases were planned with Eclipse AAA RapidArc using 6MV VMAT for a TrueBeam STx. Ion chambers measurements were performed with a PinPoint 3D micro-ion chamber in both the Standard Imaging Stereotactic Dose Verification (SI) Phantom and in the ArcCheck (AC) cavity plug...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046604/su-f-t-300-impact-of-electron-density-modeling-of-arccheck-cylindricaldiode-array-on-3dvh-patient-specific-qa-software-tool-analysis
#8
P Patwe, V Mhatre, P Dandekar
PURPOSE: 3DVH software is a patient specific quality assurance tool which estimates the 3D dose to the patient specific geometry with the help of Planned Dose Perturbation algorithm. The purpose of this study is to evaluate the impact of HU value of ArcCHECK phantom entered in Eclipse TPS on 3D dose & DVH QA analysis. METHODS: Manufacturer of ArcCHECK phantom provides CT data set of phantom & recommends considering it as a homogeneous phantom with electron density (1...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28042822/enduring-sexually-dimorphic-impact-of-in-utero-exposure-to-elevated-levels-of-glucocorticoids-on-midbrain-dopaminergic-populations
#9
REVIEW
Glenda E Gillies, Kanwar Virdee, Ilse Pienaar, Felwah Al-Zaid, Jeffrey W Dalley
Glucocorticoid hormones (GCs) released from the fetal/maternal glands during late gestation are required for normal development of mammalian organs and tissues. Accordingly, synthetic glucocorticoids have proven to be invaluable in perinatal medicine where they are widely used to accelerate fetal lung maturation when there is risk of pre-term birth and to promote infant survival. However, clinical and pre-clinical studies have demonstrated that inappropriate exposure of the developing brain to elevated levels of GCs, either as a result of clinical over-use or after stress-induced activation of the fetal/maternal adrenal cortex, is linked with significant effects on brain structure, neurological function and behaviour in later life...
December 30, 2016: Brain Sciences
https://www.readbyqxmd.com/read/28042095/reduced-noradrenergic-innervation-of-ventral-midbrain-dopaminergic-cell-groups-and-the-subthalamic-nucleus-in-mptp-treated-parkinsonian-monkeys
#10
Gunasingh Jeyaraj Masilamoni, Olivia Groover, Yoland Smith
There is anatomical and functional evidence that ventral midbrain dopaminergic (DA) cell groups and the subthalamic nucleus (STN) receive noradrenergic innervation in rodents, but much less is known about these interactions in primates. Degeneration of NE neurons in the locus coeruleus (LC) and related brainstem NE cell groups is a well-established pathological feature of Parkinson's disease (PD), but the development of such pathology in animal models of PD has been inconsistent across species and laboratories...
December 30, 2016: Neurobiology of Disease
https://www.readbyqxmd.com/read/28032937/prognostic-value-of-pretreatment-peripheral-blood-markers-in-paranasal-sinus-cancer-neutrophil-to-lymphocyte-and-platelet-to-lymphocyte-ratio
#11
Mario Turri-Zanoni, Giovanni Salzano, Alessia Lambertoni, Marta Giovannardi, Apostolos Karligkiotis, Paolo Battaglia, Paolo Castelnuovo
BACKGROUND: Pretreatment hematological markers have emerged as prognostic factors for several cancers. The purpose of this study was to present our investigation of the value of neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) in predicting recurrence and mortality for patients with primary sinonasal cancers (SNCs). METHODS: We carried out a retrospective review of patients with SNC who had been treated using endoscopic approaches from 2002 to 2014 at a single institute...
December 29, 2016: Head & Neck
https://www.readbyqxmd.com/read/28025884/a-well-defined-silicon-nanocone-carbon-structure-for-demonstrating-exclusive-influences-of-carbon-coating-on-silicon-anode-of-lithium-ion-batteries
#12
Chao Wang, Fei Luo, Hao Lu, Xiaohui Rong, Bonan Liu, Geng Chu, Yu Sun, Baogang Quan, Jieyun Zheng, Junjie Li, Changzhi Gu, Xinping Qiu, Hong Li, Liquan Chen
Nanotechnology and carbon coating have been applied to silicon anodes to achieve excellent lithium-ion batteries, but the exclusive influence of carbon coating on solid-electrolyte interphase (SEI) formation is difficult to exhibit distinctly because of the impurity and morphological irregularity of most nanostructured anodes. Here, we design a silicon nanocone-carbon (SNC-C) composite structure as a model anode to demonstrate the significant influences of carbon coating on SEI formation and electrochemical performance, unaffectedly as a result of pure electrode component and distinctly due to regular nanocone morphology...
January 9, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28025799/upregulated-expression-of-trim32-is-involved-in-schwann-cell-differentiation-migration-and-neurite-outgrowth-after-sciatic-nerve-crush
#13
Yonghua Liu, Weijie Wu, Huiguang Yang, Zhengming Zhou, Xiaojian Zhu, Chi Sun, Yuxi Liu, Zhaohui Yu, Yuyan Chen, Youhua Wang
Tripartite motif containing 32 (TRIM32), a member of the tripartite motif (TRIM) family, plays an indispensable role in myoblast proliferation. It also regulates neuron and skeletal muscle stem cell differentiation. Although it is of great importance, we know little about the roles of TRIM32 during peripheral nervous system injury. Here, we examined the dynamic changes of TRIM32 in acute sciatic nerve crush (SNC) model. After crush, TRIM32 rapidly increased and reached the climax at 1 week but then gradually declined to the normal level at 4 weeks post-injury...
December 26, 2016: Neurochemical Research
https://www.readbyqxmd.com/read/27995326/using-a-novel-pv-cre-rat-model-to-characterize-pallidonigral-cells-and-their-terminations
#14
Yoon-Mi Oh, Fuyuki Karube, Susumu Takahashi, Kenta Kobayashi, Masahiko Takada, Motokazu Uchigashima, Masahiko Watanabe, Kayo Nishizawa, Kazuto Kobayashi, Fumino Fujiyama
In the present study, we generated a novel parvalbumin (PV)-Cre rat model and conducted detailed morphological and electrophysiological investigations of axons from PV neurons in globus pallidus (GP). The GP is considered as a relay nucleus in the indirect pathway of the basal ganglia (BG). Previous studies have used molecular profiling and projection patterns to demonstrate cellular heterogeneity in the GP; for example, PV-expressing neurons are known to comprise approximately 50% of GP neurons and represent majority of prototypic neurons that project to the subthalamic nucleus and/or output nuclei of BG, entopeduncular nucleus and substantia nigra (SN)...
December 19, 2016: Brain Structure & Function
https://www.readbyqxmd.com/read/27993708/subtypes-evaluation-of-motor-dysfunction-in-parkinson-s-disease-using-neuromelanin-sensitive-magnetic-resonance-imaging
#15
Yuanyuan Xiang, Tao Gong, Junwei Wu, Jifeng Li, Yan Chen, Yongxiang Wang, Shan Li, Lin Cong, Youting Lin, Yuxiang Han, Ling Yin, Guangbin Wang, Yifeng Du
Parkinson's disease (PD) is characterized by the loss of neuromelanin (NM)-containing neurons in the substantia nigra pars compacta (SNc), and it is divided into two motor subtypes: the postural instability gait difficulty (PIGD) and the tremor dominant (TD) subtypes. With NM-sensitive Magnetic Resonance Imaging (NM-MRI), investigators have been able to accurately detect signal attenuation in SNc of PD; however, the difference of NM loss between PIGD and TD subtypes is still unclear. Thus, the aim of this study was to evaluate the differences in NM-MRI between PD motor subtypes...
December 16, 2016: Neuroscience Letters
https://www.readbyqxmd.com/read/27938993/meta-analysis-of-701-published-cases-of-sinonasal-neuroendocrine-carcinoma-the-importance-of-differentiation-grade-in-determining-treatment-strategy
#16
REVIEW
Tom P van der Laan, René Iepsma, Max J H Witjes, Bernard F A M van der Laan, Boudewijn E C Plaat, Gyorgy B Halmos
The aim of this meta-analysis was to provide treatment guidelines for sinonasal neuroendocrine carcinoma (SNC) by combining all available data in the literature. A literature search for all studies concerning SNC was performed against the MEDLINE and EMBASE databases. Available clinical data was normalized, pooled, and statistically analyzed. A total of 701 cases of SNC were available for analysis, comprising 127 well or moderately differentiated sinonasal neuroendocrine carcinomas (SNEC), 459 sinonasal undifferentiated carcinoma (SNUC) and 115 sinonasal small cell carcinoma (SmCC)...
December 2016: Oral Oncology
https://www.readbyqxmd.com/read/27911751/the-lateral-habenula-circuitry-reward-processing-and-cognitive-control
#17
Phillip M Baker, Thomas Jhou, Bo Li, Masayuki Matsumoto, Sheri J Y Mizumori, Marcus Stephenson-Jones, Aleksandra Vicentic
There has been a growing interest in understanding the role of the lateral habenula (LHb) in reward processing, affect regulation, and goal-directed behaviors. The LHb gets major inputs from the habenula-projecting globus pallidus and the mPFC, sending its efferents to the dopaminergic VTA and SNc, serotonergic dorsal raphe nuclei, and the GABAergic rostromedial tegmental nucleus. Recent studies have made advances in our understanding of the LHb circuit organization, yet the precise mechanisms of its involvement in complex behaviors are largely unknown...
November 9, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/27863709/the-neuronal-basis-of-copper-induced-modulation-of-anxiety-state-in-rat
#18
Abbaoui Abdellatif, E L Hiba Omar, Gamrani Halima
Recently, studies have provided strong evidence indicating the involvement of trace elements in the physiopathology of psychiatric disorders, particularly anxiety. We aimed, through the present study, to describe the effect of acute exposure to Cu (10mg/kg BW) on anxiety state together with the serotoninergic and dopaminergic systems in rat by means of neurobehavioral tests (elevated plus maze, dark light box) and immunohistochemistry using anti-serotonin (5HT) and anti-tyrosine hydroxylase (TH). Our data report that Cu enhanced 5HT innervation in the dorsal raphe nucleus (DRN) together with a loss of TH expression within the ventral tegmental area (VTA), Substantia nigra compacta (SNc) and their subsequent outputs including the medial forebrain bundle (MFB) and striatum...
January 2017: Acta Histochemica
https://www.readbyqxmd.com/read/27826106/differential-spread-of-anoxic-depolarization-contributes-to-the-pattern-of-neuronal-injury-after-oxygen-and-glucose-deprivation-ogd-in-the-substantia-nigra-in-rat-brain-slices
#19
Rashika N Karunasinghe, Angus C Grey, Ravindra Telang, Srdjan M Vlajkovic, Janusz Lipski
Anoxic depolarization (AD) is an acute event evoked by brain ischemia, involving a profound loss of cell membrane potential and swelling that spreads over susceptible parts of the gray matter. Its occurrence is a strong predictor of the severity of neuronal injury. Little is known about this event in the Substantia Nigra, a midbrain nucleus critical for motor control. We tested the effects of oxygen and glucose deprivation (OGD), an in vitro model of brain ischemia, in rat midbrain slices. AD developed within 4min from OGD onset and spread in the Substantia Nigra pars reticulata (SNr), but not through the Substantia Nigra pars compacta (SNc)...
January 6, 2017: Neuroscience
https://www.readbyqxmd.com/read/27825825/changes-in-sk-channel-expression-in-the-basal-ganglia-after-partial-nigrostriatal-dopamine-lesions-in-rats-functional-consequences
#20
Christiane Mourre, Christine Manrique, Jeremy Camon, Sabrine Aidi-Knani, Thierry Deltheil, Nathalie Turle-Lorenzo, Gaelle Guiraudie-Capraz, Marianne Amalric
Parkinson's disease (PD) is a progressive neurodegenerative disease originating from the loss of dopamine (DA) neurons in the substantia nigra pars compacta (SNC). The small-conductance calcium-activated potassium (SK) channels play an essential role in the regulation of midbrain DA neuron activity patterns, as well as excitability of other types of neurons of the basal ganglia. We therefore questioned whether the SK channel expression in the basal ganglia is modified in parkinsonian rats and how this could impact behavioral performance in a reaction time task...
February 2017: Neuropharmacology
keyword
keyword
119700
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"