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systemic sclerosis guidelines

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https://www.readbyqxmd.com/read/29714655/localized-morphea-after-breast-implant-for-breast-cancer-a-case-report
#1
A Moretti, F Bianchi, I V Abbate, G Gherardi, M Bonavita, E Passoni, G Nazzaro, A Bramati, M C Dazzani, S Piva, E Paternò, N Frungillo, G Farina, N La Verde
PURPOSE: Early breast cancer follow-up guidelines for patients who underwent surgery suggest a regular and accurate clinical examination of the breast area, for an early identification of cutaneous or subcutaneous breast cancer relapse. Nonetheless, breast skin lesions arising in patients treated with mastectomy for breast cancer can be caused by several diseases. A series of diagnostic hypotheses should be considered, not only focusing on cutaneous metastasis, but also on dermatologic and systemic diseases...
March 1, 2018: Tumori
https://www.readbyqxmd.com/read/29693466/isoprostane-in-systemic-sclerosis-a-systematic-review-and-meta-analysis
#2
Paul Rj Ames, Mira Merashli, Tommaso Bucci, Jaffar Norouz-Zadeh
OBJECTIVES: to further the knowledge of oxidative stress in systemic sclerosis (SSc) we performed a systematic review and meta-analysis on studies measuring isoprostane, a vasoactive agent deriving from arachidonic acid and implicated in the vasculopathy of SSc. METHODS: systematic search following the PRISMA guidelines in PubMed and EMBASE between January-1990/December-2017 using the terms: oxidative stress, isoprostane, systemic sclerosis, scleroderma. RESULTS: After the screening process 8 studies including 240 SSc patients and 192 controls were included in the systematic review and meta-analysis, 6 investigating urinary and 2 serum isoprostane: random effect meta-analysis revealed isoprostane overgeneration in SSc (p < 0...
April 25, 2018: Modern Rheumatology
https://www.readbyqxmd.com/read/29628135/lung-transplantation-for-scleroderma-lung-disease-an-international-multicenter-observational-cohort-study
#3
Pauline Pradère, Igor Tudorache, Jesper Magnusson, Laurent Savale, Olivier Brugiere, Benoît Douvry, Martine Reynaud-Gaubert, Johanna Claustre, Aurélie Le Borgne, Are M Holm, Hans Henrik Schultz, Christiane Knoop, Laurent Godinas, Andrew J Fisher, Sandrine Hirschi, Jens Gottlieb, Jérôme Le Pavec
BACKGROUND: Due to its multisystemic nature, scleroderma is considered a relative contraindication to lung transplantation at many centers. However, recent studies suggest similar post-transplant outcomes in patients with scleroderma compared to those with other causes of interstitial lung disease (ILD). Furthermore, it remains unknown whether scleroderma-associated pulmonary arterial hypertension (PAH) influences post-transplant outcomes. Our objective in this study was to assess the indications, survival, and prognostic factors of lung or heart-lung transplantation for scleroderma lung disease...
March 15, 2018: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/29531959/rationale-and-design-of-the-screening-of-pulmonary-hypertension-in-systemic-lupus-erythematosus-sophie-study
#4
Duo Huang, Yang-Yang Cheng, Pak-Hei Chan, Jojo Hai, Kai-Hang Yiu, Hung-Fat Tse, Ka-Lam Wong, Katherine Fan, Ying Wah Li, Woon-Leung Ng, Cheuk-Wan Yim, Cheuk-Hon John Wong, Lai-Shan Tam, Priscilla C H Wong, Chi-Yuen Wong, Chup-Hei Ho, Alexander M H Leung, Chi-Chiu Mok, Ho Lam, Chak-Sing Lau, Tommy Cheung, Carmen Ho, Sharon W Y Law, Esther W Chan, Li-Xue Yin, Wen-Sheng Yue, Toi Meng Mok, Mario Alberto Evora, Chung-Wah Siu
Current guideline-recommended screening for pulmonary hypertension in patients with systemic sclerosis has not been evaluated in systemic lupus erythematosus (SLE), which is disproportionately prevalent in Asians. This multicentre, cross-sectional screening study aims to study the prevalence of pulmonary hypertension among SLE patients using these guidelines, and identify independent predictors and develop a prediction model for pulmonary hypertension in SLE patients. SLE patients from participating centres will undergo an echocardiography- and biomarker-based pulmonary hypertension screening procedure as in the DETECT study...
January 2018: ERJ Open Research
https://www.readbyqxmd.com/read/29502236/a-review-of-recent-advances-using-tocilizumab-in-the-treatment-of-rheumatic-diseases
#5
REVIEW
Andrea Rubbert-Roth, Daniel E Furst, Jan Michael Nebesky, Angela Jin, Erhan Berber
Tocilizumab (TCZ) is the first humanized anti-interleukin-6 (IL-6) receptor monoclonal antibody approved for the treatment of patients with rheumatoid arthritis (RA), Castleman's disease, polyarticular and systemic juvenile idiopathic arthritis, and, most recently, giant cell arteritis as well as for the treatment of chimeric antigen receptor T cell therapy-induced cytokine release syndrome. The global clinical development program for TCZ provides a wealth of clinical data on intravenous TCZ, and more recent studies in patients with RA have provided evidence characterizing the role of intravenous TCZ as monotherapy in early disease and led to the introduction of a subcutaneous formulation of TCZ...
June 2018: Rheumatology and Therapy
https://www.readbyqxmd.com/read/29480591/atherosclerotic-vascular-disease-in-the-autoimmune-rheumatologic-woman
#6
REVIEW
Reto Daniel Kurmann, Rekha Mankad
Autoimmune rheumatologic conditions have increased cardiovascular morbidity and mortality compared to the general population. Many of these diseases occur more commonly in women, such as rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), systemic sclerosis, and Sjogren's. Most of the literature that has identified the link between autoimmune diseases and atherosclerotic cardiovascular disease (ASCVD) has been regarding patients with RA and SLE. The reason for the increased ASCVD is related to both traditional risk factors for atherosclerosis and nontraditional risk factors such as the burden of inflammation...
February 2018: Clinical Cardiology
https://www.readbyqxmd.com/read/29444467/olfactory-function-in-systemic-lupus-erythematosus-and-systemic-sclerosis-a-longitudinal-study-and-review-of-the-literature
#7
REVIEW
Mariana Freschi Bombini, Fernando Augusto Peres, Aline Tamires Lapa, Nailú Angélica Sinicato, Beatriz Ricato Quental, Ágatha de Souza Melo Pincelli, Tiago Nardi Amaral, Caroline Cristina Gomes, Ana Paula Del Rio, João Francisco Marques-Neto, Lilian T L Costallat, Paula Teixeira Fernandes, Fernando Cendes, Leticia Rittner, Simone Appenzeller
BACKGROUND/PURPOSE: To evaluate olfactory function in systemic lupus erythematosus (SLE), systemic sclerosis (SSc) and healthy controls over a 2-year period, and to determine the association of olfactory dysfunction with age, disease activity, disease damage, treatment, anxiety and depression symptoms and limbic structures volumes. METHODS: Consecutive SLE and SSc patients were enrolled in this study. Clinical, laboratory disease activity and damage were assessed according to diseases specific guidelines...
April 2018: Autoimmunity Reviews
https://www.readbyqxmd.com/read/29426066/screening-high-resolution-computed-tomography-of-the-chest-to-detect-interstitial-lung-disease-in-systemic-sclerosis-a-global-survey-of-rheumatologists
#8
Elana J Bernstein, Dinesh Khanna, David J Lederer
No abstract text is available yet for this article.
February 9, 2018: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29415230/factors-influencing-early-referral-early-diagnosis-and-management-in-patients-with-diffuse-cutaneous-systemic-sclerosis
#9
Oliver Distler, Yannick Allanore, Christopher P Denton, Marco Matucci-Cerinic, Janet E Pope, Barbara Hinzmann, Siobhan Davies, Janethe de Oliveira Pena, Dinesh Khanna
Objective: To gain insight into clinical practice regarding referral, early diagnosis and other aspects of the management of patients with dcSSc in Europe and the USA. Methods: Semi-structured interviews were conducted with 84 rheumatologists (or internal medicine physicians) and 40 dermatologists in different countries (the UK, France, Germany, Italy, Spain and the USA). Physicians were asked to identify key steps in the patient pathway relating to patient presentation, diagnosis and referral, in addition to other treatment and follow-up processes...
May 1, 2018: Rheumatology
https://www.readbyqxmd.com/read/29352526/ectrims-ean-guideline-on-the-pharmacological-treatment-of-people-with-multiple-sclerosis
#10
X Montalban, R Gold, A J Thompson, S Otero-Romero, M P Amato, D Chandraratna, M Clanet, G Comi, T Derfuss, F Fazekas, H P Hartung, E Havrdova, B Hemmer, L Kappos, R Liblau, C Lubetzki, E Marcus, D H Miller, T Olsson, S Pilling, K Selmaj, A Siva, P S Sorensen, M P Sormani, C Thalheim, H Wiendl, F Zipp
BACKGROUND AND PURPOSE: Multiple sclerosis (MS) is a complex disease of the central nervous system. As new drugs are becoming available, knowledge on diagnosis and treatment must continuously evolve. There is therefore a need for a reference tool compiling current data on benefit and safety, to aid professionals in treatment decisions and use of resources across Europe. The European Committee of Treatment and Research in Multiple Sclerosis (ECTRIMS) and the European Academy of Neurology (EAN) have joined forces to meet this need...
February 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29332746/is-pilates-an-effective-rehabilitation-tool-a-systematic-review
#11
REVIEW
Keira Byrnes, Ping-Jung Wu, Stephney Whillier
BACKGROUND: Pilates is a system of exercise focusing upon controlled movement, stretching and breathing. Pilates is popular today not only for physical fitness but also for rehabilitation programs. This paper is a review of the literature on the effectiveness of Pilates as a rehabilitation tool in a wide range of conditions in an adult population. METHODS: A systematic literature review was carried out according to the PRISMA guidelines. Electronic databases were searched for cohort studies or randomised controlled trials (RCTs), and inclusion and exclusion criteria were applied...
January 2018: Journal of Bodywork and Movement Therapies
https://www.readbyqxmd.com/read/29328521/central-vein-sign-differentiates-multiple-sclerosis-from-central-nervous-system-inflammatory-vasculopathies
#12
Pietro Maggi, Martina Absinta, Matteo Grammatico, Luisa Vuolo, Giacomo Emmi, Giovanna Carlucci, Gregorio Spagni, Alessandro Barilaro, Anna Maria Repice, Lorenzo Emmi, Domenico Prisco, Vittorio Martinelli, Roberta Scotti, Niloufar Sadeghi, Gaetano Perrotta, Pascal Sati, Bernard Dachy, Daniel S Reich, Massimo Filippi, Luca Massacesi
OBJECTIVES: In multiple sclerosis (MS), magnetic resonance imaging (MRI) is a sensitive tool for detecting white matter lesions, but its diagnostic specificity is still suboptimal; ambiguous cases are frequent in clinical practice. Detection of perivenular lesions in the brain (the "central vein sign") improves the pathological specificity of MS diagnosis, but comprehensive evaluation of this MRI biomarker in MS-mimicking inflammatory and/or autoimmune diseases, such as central nervous system (CNS) inflammatory vasculopathies, is lacking...
February 2018: Annals of Neurology
https://www.readbyqxmd.com/read/29297205/cyclophosphamide-for-connective-tissue-disease-associated-interstitial-lung-disease
#13
REVIEW
Hayley Barnes, Anne E Holland, Glen P Westall, Nicole Sl Goh, Ian N Glaspole
BACKGROUND: Approximately one-third of individuals with interstitial lung disease (ILD) have associated connective tissue disease (CTD). The connective tissue disorders most commonly associated with ILD include scleroderma/systemic sclerosis (SSc), rheumatoid arthritis, polymyositis/dermatomyositis, and Sjögren's syndrome. Although many people with CTD-ILD do not develop progressive lung disease, a significant proportion do progress, leading to reduced physical function, decreased quality of life, and death...
January 3, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29260540/conservative-management-of-adult-neurogenic-lower-urinary-tract-dysfunction
#14
Paolo DI Benedetto, Enrico Finazzi-Agrò
Neurogenic lower urinary tract dysfunction (NLTUD) is commonly encountered in neuro-rehabilitation settings and is caused by a variety of pathologies. The management of spinal cord injury (SCI) has been the model of reference for the approach to NLTUD due to many other diseases of the central and peripheral nervous system. The decline in renal-related mortality in SCI patients after the introduction of clean intermittent catheterization in association with pharmacological treatment (antimuscarinics in particular), and the algorithms proposed since 1998 by the International Consultations on Incontinence underline the need of early assessment and treatment of urinary incontinence and/or urinary retention in neuropathic patients...
December 2017: European Journal of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/29237073/frequencies-of-borderline-pulmonary-hypertension-before-and-after-the-detect-algorithm-results-from-a-prospective-systemic-sclerosis-cohort
#15
Anna-Maria Hoffmann-Vold, Håvard Fretheim, Øyvind Midtvedt, Karin Kilian, Marianne Angelshaug, Asad Chaudhary, Ragnar Gunnarsson, Cathrine Brunborg, Torhild Garen, Arne K Andreassen, Einar Gude, Øyvind Molberg
Objective: The DETECT algorithm was developed for screening patients with SSc at high risk of pulmonary arterial hypertension (PAH). We evaluated the impact of this algorithm in a SSc population. Methods: Patients from the unselected, prospective Oslo University Hospital SSc study were divided into the Early and DETECT cohorts, respectively, depending on whether an incident right heart catheterization (RHC) was performed before (2009-13) or after (2014-17) the DETECT algorithm was instituted...
December 11, 2017: Rheumatology
https://www.readbyqxmd.com/read/29193951/-disseminated-tuberculosis-in-a-patient-with-overlap-syndrome-challenges-in-preventing
#16
Sergio García-Méndez, Lamberto Miguel Caballero-Zavala, Imelda García-Olivera, Fortunato Vásquez-Manuel, Gerardo Pérez-Bustamante, Fabián Tafoya-Ramírez
Patients with autoimmune rheumatic diseases are at increased risk for developing infections and these are associated with increased morbidity and mortality from these diseases, especially in patients with systemic lupus erythematosus, rheumatoid arthritis, systemic sclerosis and autoimmune inflammatory myopathies. The objective of this paper is to address the challenges in detecting latent tuberculosis in immunosuppressed patients and the initiation of prophylactic treatment because currently there are no well-defined guidelines indicating what action to take for detection and treatment; so far the available scientific evidence is scarce and some methodological shortcomings...
September 2017: Revista Médica del Instituto Mexicano del Seguro Social
https://www.readbyqxmd.com/read/29157402/effective-utilization-of-mri-in-the-diagnosis-and-management-of-multiple-sclerosis
#17
REVIEW
Antonio Giorgio, Nicola De Stefano
MRI is the most important tool for diagnosis and management of patients with multiple sclerosis (MS). MRI shows high sensitivity for detection of white matter lesions in the central nervous system and specificity for lesion dissemination in space and time. MRI is also used for tracking disease activity, prognostic evaluation, and monitoring the efficacy and safety of disease-modifying treatments. Nonconventional MRI measures (eg, brain atrophy) and quantitative measures of advanced MRI can capture features of MS beyond WM lesions but are not currently implemented in clinical practice...
February 2018: Neurologic Clinics
https://www.readbyqxmd.com/read/29139001/the-assessment-for-disinvestment-of-intramuscular-interferon-beta-for-relapsing-remitting-multiple-sclerosis-in-brazil
#18
REVIEW
Livia Lovato Pires de Lemos, Augusto Afonso Guerra Júnior, Marisa Santos, Carlos Magliano, Isabela Diniz, Kathiaja Souza, Ramon Gonçalves Pereira, Juliana Alvares, Brian Godman, Marion Bennie, Ivan Ricardo Zimmermann, Vânia Crisitna Canuto Dos Santos, Clarice Alegre Pretramale, Francisco de Assis Acurcio
In Brazil, inclusion and exclusion of health technologies within the Unified Health System (SUS) is the responsibility of the National Committee for Health Technology Incorporation (CONITEC). A recent Cochrane systematic review demonstrated that intramuscular interferon beta 1a (IFN-β-1a-IM) was inferior to the other beta interferons (IFN-βs) for multiple sclerosis (MS). As a result, CONITEC commissioned an analysis to review possible disinvestment within SUS. The objective of this paper is to describe the disinvestment process for IFN-β-1a-IM in Brazil...
February 2018: PharmacoEconomics
https://www.readbyqxmd.com/read/29049870/dendrimers-breaking-the-paradigm-of-current-musculoskeletal-autoimmune-therapies
#19
REVIEW
Daniel B Rodrigues, Joaquim M Oliveira, Tírcia C Santos, Rui L Reis
The advances achieved by cell-based therapies to treat autoimmune diseases such as rheumatoid arthritis (RA) and multiple sclerosis (MS), despite promising, are still insufficient for the current demands. RA and MS therapeutic approaches follow world guidelines to use disease modifying drugs and biological agents that, regardless of some good results in clinical outcomes, are well known for several systemic secondary side effects. Dendrimers are custom-made nanoparticles with proved clinical potential, displaying proper size, chemistries, immunomodulatory, and anti-inflammatory properties...
March 2018: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/29019147/mri-and-multiple-sclerosis-the-evolving-role-of-mri-in-the-diagnosis-and-management-of-ms-a-clinician-s-perspective
#20
H Kearney, A M Cahalane, R P Killeen, C McGuigan
The diagnosis of multiple sclerosis (MS) is based on a history consistent with demyelination of the central nervous system and corresponding physical signs on examination. However, this diagnosis is supported radiologically using magnetic resonance imaging (MRI). At present, MRI serves as the most reliable and widely available biomarker for the practising clinician to measure disease activity and treatment response in MS. As MRI remains central to both the diagnosis and management of MS, this paper provides proposed guidelines for its use in routine clinical practice...
October 10, 2017: Irish Journal of Medical Science
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