Parvez M Shaikh, Sarah A Singh, Fiori Alite, John A Vargo, Bahman Emami, Meng-Jia Wu, Geraldine Jacobson, Veli Bakalov, William Small, Basem Dahshan, Joshua Weir, Paul B Renz, Matthew M Harkenrider
PURPOSE: Several retrospective series have reported that patients with collagen vascular disease (CVD) are at increased risk of radiation (RT) toxicity. However, the evidence is mixed, and many series lack control groups. We performed a meta-analysis including only case-cohort or randomized studies that examined the risk of RT toxicity for patients with CVD compared with controls. METHODS AND MATERIALS: Meta-analysis of Observational Studies in Epidemiology guidelines were used to perform a comprehensive search identifying case-control or randomized studies reporting RT toxicity outcomes for patients with CVD versus controls...
December 1, 2021: International Journal of Radiation Oncology, Biology, Physics