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Dynamic contrasted enhance MRI

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https://www.readbyqxmd.com/read/29223713/diagnostic-values-of-dce-mri-and-dsc-mri-for-differentiation-between-high-grade-and-low-grade-gliomas-a-comprehensive-meta-analysis
#1
Jianye Liang, Dexiang Liu, Peng Gao, Dong Zhang, Hanwei Chen, Changzheng Shi, Liangping Luo
RATIONALE AND OBJECTIVES: This study aimed to collect the studies on the role of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and dynamic susceptibility contrast MRI (DSC-MRI) in differentiating the grades of gliomas, and evaluate the diagnostic performances of relevant quantitative parameters in glioma grading. MATERIALS AND METHODS: We systematically searched studies on the diagnosis of gliomas with DCE-MRI or DSC-MRI in Medline, PubMed, China National Knowledge Infrastructure database, Cochrane Library, and Embase published between January 2005 and December 2016...
December 6, 2017: Academic Radiology
https://www.readbyqxmd.com/read/29219225/dce-mri-texture-analysis-with-tumor-subregion-partitioning-for-predicting-ki-67-status-of-estrogen-receptor-positive-breast-cancers
#2
Ming Fan, Hu Cheng, Peng Zhang, Xin Gao, Juan Zhang, Guoliang Shao, Lihua Li
BACKGROUND: Breast tumor heterogeneity is related to risk factors that lead to worse prognosis, yet such heterogeneity has not been well studied. PURPOSE: To predict the Ki-67 status of estrogen receptor (ER)-positive breast cancer patients via analysis of tumor heterogeneity with subgroup identification based on patterns of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI). STUDY TYPE: Retrospective study. POPULATION: Seventy-seven breast cancer patients with ER-positive breast cancer were investigated, of whom 51 had low Ki-67 expression...
December 8, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29217526/first-in-human-phase-i-study-of-single-agent-vanucizumab-a-first-in-class-bi-specific-anti-ang-2-anti-vegf-antibody-in-adult-patients-with-advanced-solid-tumors
#3
Manuel Hidalgo, Maria Martinez-Garcia, Christophe Le Tourneau, Christophe Massard, Elena Garralda, Valentina Boni, Alvaro Taus, Joan Albanell, Marie-Paule Sablin, Marie Alt, Rastilav Bahleda, Andreea Varga, Christophe Boetsch, Izolda Franjkovic, Florian Heil, Angelika Lahr, Katharina Lechner, Anthony Morel, Tapan K Nayak, Simona Rossomanno, Kevin Smart, Kay-Gunnar Stubenrauch, Oliver Krieter
PURPOSE: Vanucizumab is an investigational anti-angiogenic, first-in-class, bi-specific monoclonal antibody targeting VEGF-A and angiopoietin-2 (Ang-2). This first-in-human study evaluated the safety, pharmacokinetics, pharmacodynamics, and antitumor activity of vanucizumab in adults with advanced solid tumors refractory to standard therapies. EXPERIMENTAL DESIGN: Patients received escalating bi-weekly (q2w; 3-30 mg/kg) or weekly (qw; 10-30 mg/kg) intravenous doses guided by a Bayesian logistic regression model with overdose control...
December 7, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29217300/dynamic-magnetic-resonance-imaging-of-the-breast-comparison-of-gadobutrol-vs-gd-dtpa
#4
F Escribano, M Sentís, J C Oliva, L Tortajada, M Villajos, A Martín, S Ganau
OBJECTIVE: To compare the pharmacokinetic profile of gadobutrol versus Gd-DTPA in dynamic contrast-enhanced MRI (DCE-MRI) in patients with breast cancer. Secondary objectives included comparing the safety profiles and diagnostic efficacy of the two contrast agents for detecting additional malignant lesions. MATERIAL AND METHODS: This retrospective observational study included 400 patients with histologically confirmed breast cancer; 200 underwent DCE-MRI with Gd-DTPA (Magnevist®) and 200 underwent DCE-MRI with gadobutrol (Gadovist®)...
December 4, 2017: Radiología
https://www.readbyqxmd.com/read/29213007/the-value-of-lesion-size-as-an-adjunct-to-the-bi-rads-mri-2013-descriptors-in-the-diagnosis-of-solitary-breast-masses
#5
Makiko Kawai, Masako Kataoka, Shotaro Kanao, Mami Iima, Natsuko Onishi, Akane Ohashi, Rena Sakaguchi, Masakazu Toi, Kaori Togashi
PURPOSE: This study aimed to evaluate the MRI findings of breast solitary masses in diagnostic procedures to decide the appropriate category based on American College of Radiology (ACR) BI-RADS-MRI 2013, with the focus on lesion size. METHODS: A retrospective review of 2,603 consecutive breast MRI reports identified 250 pathologically-proven solitary breast masses. Dynamic-contrast enhanced images and diffusion-weighted images were performed on a 3.0/1.5 Tesla Scanner with a 16/4 channel dedicated breast coil...
December 7, 2017: Magnetic Resonance in Medical Sciences: MRMS
https://www.readbyqxmd.com/read/29205621/multiparametric-characterization-of-response-to-anti-angiogenic-therapy-using-uspio-contrast-enhanced-mri-in-combination-with-dynamic-contrast-enhanced-mri
#6
Jana Kim, Eugene Kim, Leslie R Euceda, Dan E Meyer, Karina Langseth, Tone F Bathen, Siver A Moestue, Else Marie Huuse
BACKGROUND: Steady state susceptibility contrast (SSC)-MRI provides information on vascular morphology but is a rarely used method. PURPOSE: To investigate the utility of the ultrasmall superparamagnetic iron oxide particles (USPIOs) GEH121333 for measuring tumor response to bevacizumab and compare this with gadolinium-based DCE-MRI. STUDY TYPE: Prospective preclinical animal model study. ANIMAL MODEL: Mice bearing subcutaneous TOV-21G human ovarian cancer xenografts treated with bevacizumab (n = 9) or saline (n = 9)...
December 4, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29201942/dynamic-contrast-enhanced-magnetic-resonance-imaging-and-diffusion-weighted-magnetic-resonance-imaging-for-predicting-the-response-of-locally-advanced-breast-cancer-to-neoadjuvant-therapy-a-meta-analysis
#7
John Virostko, Allison Hainline, Hakmook Kang, Lori R Arlinghaus, Richard G Abramson, Stephanie L Barnes, Jeffrey D Blume, Sarah Avery, Debra Patt, Boone Goodgame, Thomas E Yankeelov, Anna G Sorace
This meta-analysis assesses the prognostic value of quantitative dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and diffusion-weighted MRI (DW-MRI) performed during neoadjuvant therapy (NAT) of locally advanced breast cancer. A systematic literature search was conducted to identify studies of quantitative DCE-MRI and DW-MRI performed during breast cancer NAT that report the sensitivity and specificity for predicting pathological complete response (pCR). Details of the study population and imaging parameters were extracted from each study for subsequent meta-analysis...
January 2018: Journal of Medical Imaging
https://www.readbyqxmd.com/read/29201581/contrast-enhancement-of-aneurysm-sac-post-pipeline-treatment-interpreted-as-recanalization
#8
Annie J Tsay, Sara Langan, Scott Simon
Multiple imaging modalities are available to evaluate aneurysms post-flow diverter (FD) placement. Though digital subtraction angiography (DSA) is the gold standard imaging modality post-FD placement, it is not perfect, and neither are other techniques, including contrast-enhanced magnetic resonance angiography (CE-MRA) and magnetic resonance imaging (MRI). We present a case of a 73-year-old woman with a right internal carotid artery (ICA) aneurysm treated with a pipeline embolization device (PED). Initial follow-up post-PED placement by three-dimensional time-of-flight (3D-TOF) MRA demonstrated aneurysm occlusion, which was confirmed by computed tomography angiography (CTA) and CE-MRA in subsequent follow-up appointments...
September 29, 2017: Curēus
https://www.readbyqxmd.com/read/29197910/detection-and-characterization-of-small-superficially-located-focal-liver-lesions-by-contrast-enhanced-ultrasound-with-high-frequency-transducers
#9
Wen-Ping Wang, Yi Dong, Jiaying Cao, Feng Mao, Yadan Xu, Qin Si, Christoph F Dietrich
AIM: To evaluate the benefits of contrast-enhanced ultrasound (CEUS) with high frequency transducers in the detection and characterization of small superficially located focal liver lesions (FLLs). MATERIAL AND METHODS: From January 2015 to October 2016, 27 superficial FLLs detected by MRI were examined, first with the low frequency convex transducer (1-5 MHz) and afterwards with a high frequency transducer (7.5-12 MHz). High frequency dynamic CEUS was performed after a bolus injection of 2...
November 29, 2017: Medical Ultrasonography
https://www.readbyqxmd.com/read/29197390/evaluation-of-b1-inhomogeneity-effect-on-dce-mri-data-analysis-of-brain-tumor-patients-at-3t
#10
Anirban Sengupta, Rakesh Kumar Gupta, Anup Singh
BACKGROUND: Dynamic-contrast-enhanced (DCE) MRI data acquired using gradient echo based sequences is affected by errors in flip angle (FA) due to transmit B1 inhomogeneity (B1inh). The purpose of the study was to evaluate the effect of B1inh on quantitative analysis of DCE-MRI data of human brain tumor patients and to evaluate the clinical significance of B1inh correction of perfusion parameters (PPs) on tumor grading. METHODS: An MRI study was conducted on 35 glioma patients at 3T...
December 2, 2017: Journal of Translational Medicine
https://www.readbyqxmd.com/read/29193469/estimating-the-arterial-input-function-from-dynamic-contrast-enhanced-mri-data-with-compensation-for-flow-enhancement-ii-applications-in-spine-diagnostics-and-assessment-of-crohn-s-disease
#11
Jeroen J N van Schie, Cristina Lavini, Lucas J van Vliet, Gem Kramer, Indra Pieters-van den Bos, J T Marcus, Jaap Stoker, Frans M Vos
BACKGROUND: Pharmacokinetic (PK) models can describe microvascular density and integrity. An essential component of PK models is the arterial input function (AIF) representing the time-dependent concentration of contrast agent (CA) in the blood plasma supplied to a tissue. PURPOSE/HYPOTHESIS: To evaluate a novel method for subject-specific AIF estimation that takes inflow effects into account. STUDY TYPE: Retrospective study. SUBJECTS: Thirteen clinical patients referred for spine-related complaints; 21 patients from a study into luminal Crohn's disease with known Crohn's Disease Endoscopic Index of Severity (CDEIS)...
November 28, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29193415/estimating-the-arterial-input-function-from-dynamic-contrast-enhanced-mri-data-with-compensation-for-flow-enhancement-i-theory-method-and-phantom-experiments
#12
Jeroen J N van Schie, Cristina Lavini, Lucas J van Vliet, Frans M Vos
BACKGROUND: The arterial input function (AIF) represents the time-dependent arterial contrast agent (CA) concentration that is used in pharmacokinetic modeling. PURPOSE: To develop a novel method for estimating the AIF from dynamic contrast-enhanced (DCE-) MRI data, while compensating for flow enhancement. STUDY TYPE: Signal simulation and phantom measurements. PHANTOM MODEL: Time-intensity curves (TICs) were simulated for different numbers of excitation pulses modeling flow effects...
November 28, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29193339/a-rapid-t1-mapping-method-for-assessment-of-murine-kidney-viability-using-dynamic-manganese-enhanced-magnetic-resonance-imaging
#13
Kai Jiang, Hui Tang, Prasanna K Mishra, Slobodan I Macura, Lilach O Lerman
PURPOSE: Dynamic manganese-enhanced MRI (MEMRI) allows assessment of tissue viability by tracing manganese uptake. We aimed to develop a rapid T1 mapping method for dynamic MEMRI to facilitate assessments of murine kidney viability. METHODS: A multi-slice saturation recovery fast spin echo (MSRFSE) was developed, validated, and subsequently applied in dynamic MEMRI at 16.4T on ischemic mouse kidneys after 4 weeks of unilateral renal artery stenosis (RAS). Baseline T1 values and post-contrast R1 (1/T1 ) changes were measured in cortex (CO), outer (OSOM), inner (ISOM) strips of outer medulla, and inner medulla (IM)...
November 28, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29193288/characterization-of-tumor-vascular-permeability-using-natural-dextrans-and-cest-mri
#14
Yuguo Li, Yuan Qiao, Hanwei Chen, Renyuan Bai, Verena Staedtke, Zheng Han, Jiadi Xu, Kannie W Y Chan, Nirbhay Yadav, Jeff W M Bulte, Shibin Zhou, Peter C M van Zijl, Guanshu Liu
PURPOSE: To investigate the use of natural dextrans as nano-sized chemical exchange saturation transfer (CEST) MRI probes for characterizing size-dependent tumor vascular permeability. METHODS: Dextrans of different molecular weight (10, 70, 150, and 2000 kD) were characterized for their CEST contrast. Mice (N = 5) bearing CT26 subcutaneous colon tumors were injected intravenously with 10 kD (D10, 6 nm) and 70 kD (D70, 12 nm) dextran at a dose of 375 mg/kg...
November 28, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29193260/racer-grasp-respiratory-weighted-aortic-contrast-enhancement-guided-and-coil-unstreaking-golden-angle-radial-sparse-mri
#15
Li Feng, Chenchan Huang, Krishna Shanbhogue, Daniel K Sodickson, Hersh Chandarana, Ricardo Otazo
PURPOSE: To develop and evaluate a novel dynamic contrast-enhanced imaging technique called RACER-GRASP (Respiratory-weighted, Aortic Contrast Enhancement-guided and coil-unstReaking Golden-angle RAdial Sparse Parallel) MRI that extends GRASP to include automatic contrast bolus timing, respiratory motion compensation, and coil-weighted unstreaking for improved imaging performance in liver MRI. METHODS: In RACER-GRASP, aortic contrast enhancement (ACE) guided k-space sorting and respiratory-weighted sparse reconstruction are performed using aortic contrast enhancement and respiratory motion signals extracted directly from the acquired data...
November 28, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29191245/3-0t-mri-for-long-term-observation-of-lung-nodules-post-cryoablation-a-pilot-study
#16
Jing Li, Jinrong Qu, Hongkai Zhang, Yingshu Wang, Lin Zheng, Xiang Geng, Yan Zhao, Hailiang Li
BACKGROUND: The purpose of this study was to use serial magnetic resonance imaging (MRI) examinations to observe changes in malignant lung tumors over time post-cryoablation. METHODS: The study protocol was approved by Institutional Review Board, and written informed consent was obtained from each participant in accordance with the Declaration of Helsinki. Patients with primary or metastatic lung tumors eligible for cryoablation were included in this prospective study...
December 1, 2017: Cancer Imaging: the Official Publication of the International Cancer Imaging Society
https://www.readbyqxmd.com/read/29190227/potential-of-noncontrast-magnetic-resonance-imaging-with-diffusion-weighted-imaging-in-characterization-of-breast-lesions-intraindividual-comparison-with-dynamic-contrast-enhanced-magnetic-resonance-imaging
#17
Pascal A T Baltzer, Hubert Bickel, Claudio Spick, Georg Wengert, Ramona Woitek, Panagiotis Kapetas, Paola Clauser, Thomas H Helbich, Katja Pinker
OBJECTIVES: The aim of this study was to assess the potential of noncontrast magnetic resonance imaging (NC-MRI) with diffusion-weighted imaging (DWI) in characterization of breast lesions in comparison to dynamic contrast-enhanced MRI (DCE-MRI) at 3 T. MATERIALS AND METHODS: Consecutive patients with conventional imaging (mammography, ultrasound) BI-RADS 4/5 findings were included in this institutional review board-approved single-center study. All underwent 3 T breast MRI including readout-segmented DWI, DCE, and T2-weighted sequences...
November 22, 2017: Investigative Radiology
https://www.readbyqxmd.com/read/29189400/assessment-of-myometrial-invasion-in-premenopausal-grade-1-endometrial-carcinoma-is-magnetic-resonance-imaging-a-reliable-tool-in-selecting-patients-for-fertility-preserving-therapy
#18
Makoto Sakane, Masatoshi Hori, Hiromitsu Onishi, Takahiro Tsuboyama, Takashi Ota, Mitsuaki Tatsumi, Yutaka Ueda, Toshihiro Kimura, Tadashi Kimura, Noriyuki Tomiyama
OBJECTIVES: The aim of this study was to evaluate the diagnostic ability of magnetic resonance imaging (MRI) in premenopausal women with G1 endometrial carcinoma. METHODS: Twenty-six patients underwent T2W, diffusion weighted, and dynamic contrast-enhanced 3-T MRI. The degree of myometrial invasion was pathologically classified into no invasion, shallow (3 mm or less), and more. Two radiologists assessed myometrial invasion on MRI. Diagnostic accuracy, sensitivity, specificity, positive and negative predictive values, AUC, and interobserver agreement were analyzed...
November 16, 2017: Journal of Computer Assisted Tomography
https://www.readbyqxmd.com/read/29187893/detection-of-treatment-success-after-photodynamic-therapy-using-dynamic-contrast-enhanced-magnetic-resonance-imaging
#19
Tom J L Schreurs, Igor Jacobs, Klaas Nicolay, Jeanine J Prompers, Gustav J Strijkers
Early evaluation of response to therapy is crucial for selecting the optimal therapeutic follow-up strategy for cancer patients. PDT is a photochemistry-based treatment modality that induces tumor tissue damage by cytotoxic oxygen radicals, generated by a pre-injected photosensitive drug upon light irradiation of tumor tissue. Vascular shutdown is an important mechanism of tumor destruction for most PDT protocols. In this study, we assessed the suitability of Dynamic Contrast-Enhanced Magnetic Resonance Imaging (DCE-MRI) to evaluate treatment efficacy within a day after photodynamic therapy (PDT), using the tumor vascular response as a biomarker for treatment success...
2017: Theranostics
https://www.readbyqxmd.com/read/29187481/pre-surgical-multiparametric-assessment-of-breast-lesions-using-3-tesla-magnetic-resonance
#20
Hynek Mirka, Radek Tupy, Andrea Narsanska, Ondrej Hes, Jiri Ferda
BACKGROUND/AIM: The aim of this study was to evaluate experience with multiparametric breast imaging on 3-Tesla magnetic resonance (3T-MRI) scanner using a dedicated 18-channel coil compared to histological findings in women after surgery. MATERIALS AND METHODS: The study included 100 women with 105 Breast Imaging Reporting and Data System (BI-RADS) 4 to 6 lesions by mammography who were examined using 3T-MRI and subsequently underwent surgery. MRI included non-contrast T1, T2 and T2 short tau inversion recovery (STIR) sequences, diffusion-weighted imaging with apparent diffusion coeficient maps, postcontrast dynamic study and single-voxel MRI spectroscopy...
December 2017: Anticancer Research
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