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Dynamic contrasted enhance MRI

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https://www.readbyqxmd.com/read/29050909/bold-fmri-in-the-mouse-auditory-pathway
#1
Guilherme Blazquez Freches, Cristina Chavarrias, Noam Shemesh
The auditory pathway is widely distributed throughout the brain, and is perhaps one of the most interesting networks in the context of neuroplasticity. Accurate mapping of neural activity in the entire pathway, preferably noninvasively, and with high resolution, could be instrumental for understanding such longitudinal processes. Functional magnetic resonance imaging (fMRI) has clear advantages for such characterizations, as it is noninvasive, provides relatively high spatial resolution and lends itself for repetitive studies, albeit relying on an indirect neurovascular coupling to deliver its information...
October 16, 2017: NeuroImage
https://www.readbyqxmd.com/read/29044908/tumor-radiomic-heterogeneity-multiparametric-functional-imaging-to-characterize-variability-and-predict-response-following-cervical-cancer-radiation-therapy
#2
Stephen R Bowen, William T C Yuh, Daniel S Hippe, Wei Wu, Savannah C Partridge, Saba Elias, Guang Jia, Zhibin Huang, George A Sandison, Dennis Nelson, Michael V Knopp, Simon S Lo, Paul E Kinahan, Nina A Mayr
BACKGROUND: Robust approaches to quantify tumor heterogeneity are needed to provide early decision support for precise individualized therapy. PURPOSE: To conduct a technical exploration of longitudinal changes in tumor heterogeneity patterns on dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI), diffusion-weighted imaging (DWI) and FDG positron emission tomography / computed tomography (PET/CT), and their association to radiation therapy (RT) response in cervical cancer...
October 16, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29035992/18f-faza-pet-ct-hypoxia-imaging-of-high-grade-glioma-before-and-after-radiotherapy
#3
Paola Mapelli, Flavia Zerbetto, Elena Incerti, Gian Marco Conte, Valentino Bettinardi, Federico Fallanca, Nicoletta Anzalone, Nadia Di Muzio, Luigi Gianolli, Maria Picchio
A 57 year-old man underwent MRI with dynamic susceptibility contrast and dynamic contrast-enhanced perfusion for neurological symptoms suggesting the diagnosis of high-grade glioma. A F-FAZA PET/CT was performed because of the enrollment in a prospective clinical trial. Subsequent radiotherapy treatment has been planned based on conventional imaging; moreover, a F-FAZA PET/CT-guided treatment planning highlighting hypoxic regions has been simulated. After radiotherapy treatment, the man underwent MRI and F-FAZA PET/CT, showing partial response...
October 13, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/29034514/measurement-of-murine-single-kidney-glomerular-filtration-rate-using-dynamic-contrast-enhanced-mri
#4
Kai Jiang, Hui Tang, Prasanna K Mishra, Slobodan I Macura, Lilach O Lerman
PURPOSE: To develop and validate a method for measuring murine single-kidney glomerular filtration rate (GFR) using dynamic contrast-enhanced MRI (DCE-MRI). METHODS: This prospective study was approved by the Institutional Animal Care and Use Committee. A fast longitudinal relaxation time (T1 ) measurement method was implemented to capture gadolinium dynamics (1 s/scan), and a modified two-compartment model was developed to quantify GFR as well as renal perfusion using 16...
October 16, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29033638/tolosa-hunt-syndrome-cranial-neuroimaging-findings
#5
Çetin Kürşad Akpinar, Taner Özbenli, Hakan Doğru, Lütfi Incesu
INTRODUCTION: The etiology of Tolosa-Hunt Syndrome (THS) is still unknown. The initial standard magnetic resonance imaging (MRI) may not be sufficient for diagnosis, so dynamic contrast-enhanced MRI may be necessary to demonstrate the presence of lesions. METHODS: Seven patients diagnosed with THS according to the International Headache Society criteria (beta version) were included into the study. Patients were assessed in terms of type, age, symptoms and findings, accompanying disease, localization of the determined lesion, response to treatment, and clinical progress...
September 2017: Noro Psikiyatri Arsivi
https://www.readbyqxmd.com/read/29023572/computer-aided-detection-in-prostate-cancer-diagnostics-a-promising-alternative-to-biopsy-a-retrospective-study-from-104-lesions-with-histological-ground-truth
#6
Anika Thon, Ulf Teichgräber, Cornelia Tennstedt-Schenk, Stathis Hadjidemetriou, Sven Winzler, Ansgar Malich, Ismini Papageorgiou
BACKGROUND: Prostate cancer (PCa) diagnosis by means of multiparametric magnetic resonance imaging (mpMRI) is a current challenge for the development of computer-aided detection (CAD) tools. An innovative CAD-software (Watson Elementary™) was proposed to achieve high sensitivity and specificity, as well as to allege a correlate to Gleason grade. AIM/OBJECTIVE: To assess the performance of Watson Elementary™ in automated PCa diagnosis in our hospital´s database of MRI-guided prostate biopsies...
2017: PloS One
https://www.readbyqxmd.com/read/29023152/primary-hepatic-neoplasms-of-vascular-origin-key-imaging-features-and-differential-diagnoses-with-radiology-pathology-correlation
#7
Hailey Hye-In Choi, Maria A Manning, Anupamjit K Mehrotra, Sean Wagner, Reena C Jha
OBJECTIVE: This article describes, illustrates, and correlates imaging and pathologic features of primary vascular mesenchymal neoplasms of the liver, which arise from the vascular endothelium and perivascular epithelioid cells. CONCLUSION: Familiarity with the spectrum of benign, malignant-potential and malignant vascular neoplasms, and nonneoplastic mimickers allows consideration in the differential diagnosis of enhancing hepatic masses. Understanding relevant pathologic features facilitates recognition of key imaging features, specifically dynamic contrast enhancement patterns on CT and MRI, which provide a useful classification system...
October 12, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29020992/facile-aerobic-construction-of-iron-based-ferromagnetic-nanostructures-by-a-novel-microbial-nanofactory-isolated-from-tropical-freshwater-wetlands
#8
Patricia Jayshree Jacob, Mas Jaffri Masarudin, Mohd Zobir Hussein, Raha Abdul Rahim
BACKGROUND: Iron based ferromagnetic nanoparticles (IONP) have found a wide range of application in microelectronics, chemotherapeutic cell targeting, and as contrast enhancers in MRI. As such, the design of well-defined monodisperse IONPs is crucial to ensure effectiveness in these applications. Although these nanostructures are currently manufactured using chemical and physical processes, these methods are not environmentally conducive and weigh heavily on energy and outlays. Certain microorganisms have the innate ability to reduce metallic ions in aqueous solution and generate nano-sized IONP's with narrow size distribution...
October 11, 2017: Microbial Cell Factories
https://www.readbyqxmd.com/read/29018942/evaluation-of-an-abbreviated-screening-mri-protocol-for-patients-at-risk-for-hepatocellular-carcinoma
#9
Jennifer Y Lee, Eugene J Huo, Stefanie Weinstein, Charmaine Santos, Alexander Monto, Carlos U Corvera, Judy Yee, Thomas A Hope
PURPOSE: In this study, we compare an abbreviated screening MRI protocol (aMRI), utilizing only dynamic contrast-enhanced images, to a conventional liver MRI (cMRI) for the characterization of observations in at-risk patients. MATERIALS AND METHODS: 164 consecutive HCC screening MRIs were retrospectively analyzed. Two sets of de-identified image sets were created: one with all acquired sequences including T2- and diffusion-weighted sequences (cMRI), and one with only T1-weighted precontrast and dynamic post-contrast images utilizing an extracellular gadolinium contrast agent (aMRI)...
October 10, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/28990929/multiparametric-magnetic-resonance-imaging-for-active-surveillance-of-prostate-cancer
#10
Julie Y An, Abhinav Sidana, Peter L Choyke, Bradford Wood, Peter A Pinto, İsmail Barış Türkbey
Active surveillance has gained popularity as an acceptable management option for men with low-risk prostate cancer. Successful utilization of this strategy can delay or prevent unnecessary interventions - thereby reducing morbidity associated with overtreatment. The usefulness of active surveillance primarily depends on correct identification of patients with low-risk disease. However, current population-wide algorithms and tools do not adequately exclude high-risk disease, thereby limiting the confidence of clinicians and patients to go on active surveillance...
September 29, 2017: Balkan Medical Journal
https://www.readbyqxmd.com/read/28987672/volume-fractions-of-dce-mri-parameter-as-early-predictor-of-histologic-response-in-soft-tissue-sarcoma-a-feasibility-study
#11
Wei Xia, Zhuangzhi Yan, Xin Gao
OBJECTIVE: To find early predictors of histologic response in soft tissue sarcoma through volume transfer constant (K(trans)) analysis based on dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI). MATERIALS AND METHODS: 11 Patients with soft tissue sarcoma of the lower extremity that underwent preoperative chemoradiotherapy followed by limb salvage surgery were included in this retrospective study. For each patient, DCE-MRI data sets were collected before and two weeks after therapy initiation, and histologic tumor cell necrosis rate (TCNR) was reported at surgery...
October 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28987662/value-of-dce-mri-for-staging-and-response-evaluation-in-rectal-cancer-a-systematic-review
#12
REVIEW
Rebecca A P Dijkhoff, Regina G H Beets-Tan, Doenja M J Lambregts, Geerard L Beets, Monique Maas
PURPOSE: Aim was to perform a systematic review to evaluate the clinical value of dynamic contrast-enhanced (DCE) MRI in rectal cancer. METHODS AND MATERIALS: A systematic search was performed on Pubmed, Embase and the Cochrane library. Studies that evaluated DCE-MRI for tumour aggressiveness, primary staging and restaging after chemoradiation (CRT) were included. Information on population, DCE technique, DCE parameters and outcome (angiogenesis, staging and response) were extracted...
October 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28984142/visual-inspection-of-mr-relative-cerebral-blood-volume-maps-has-limited-value-for-distinguishing-progression-from-pseudoprogression-in-glioblastoma-multiforme-patients
#13
Melissa Kerkhof, Pauline L Tans, Rogier E Hagenbeek, Geert J Lycklama À Nijeholt, Finn K Holla, Tjeerd J Postma, Chiara S Straathof, Linda Dirven, Martin Jb Taphoorn, Maaike J Vos
AIM: We examined whether visual interpretation of relative cerebral blood volume (rCBV) color maps made with dynamic susceptibility-weighted perfusion MRI can reliably distinguish progressive disease (PD) from pseudoprogression (PsPD) in glioblastoma patients during treatment with temozolomide chemoradiation. MATERIALS & METHODS: Magnetic resonance (MR) perfusion-weighted images were evaluated based on visual inspection of rCBV maps. Sensitivity and specificity were calculated to assess if rCBV can reliably differentiate between PD and PsPD, during standard chemoradiation therapy...
October 6, 2017: CNS Oncology
https://www.readbyqxmd.com/read/28981356/comparison-of-prostate-imaging-reporting-and-data-system-versions-1-and-2-for-the-detection-of-peripheral-zone-gleason-score-3-4-7-cancers
#14
Satheesh Krishna, Matthew McInnes, Christopher Lim, Robert Lim, Shaheed W Hakim, Trevor A Flood, Nicola Schieda
OBJECTIVE: The objective of our study was to compare Prostate Imaging Reporting and Data System Version 1 (PI-RADSv1) and Prostate Imaging Reporting and Data System Version 2 (PI-RADSv2) for the detection of peripheral zone (PZ) Gleason score 3 + 4 = 7 cancers. MATERIALS AND METHODS: Forty-seven consecutive patients with 52 PZ Gleason score 3 + 4 = 7 cancers that were 0.5 cm(3) or larger underwent radical prostatectomy (RP) and 3-T MRI between 2012 and 2015. Two blinded radiologists (readers 1 and 2) retrospectively assigned PI-RADSv1 sequence (T2-weighted imaging, DWI, dynamic contrast-enhanced MRI [DCE-MRI]) and sum scores and PI-RADSv2 assessment categories...
October 5, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28979849/clinical-applications-of-advanced-magnetic-resonance-imaging-techniques-for-arthritis-evaluation
#15
REVIEW
Teodoro Martín Noguerol, Antonio Luna, Marta Gómez Cabrera, Alexie D Riofrio
Magnetic resonance imaging (MRI) has allowed a comprehensive evaluation of articular disease, increasing the detection of early cartilage involvement, bone erosions, and edema in soft tissue and bone marrow compared to other imaging techniques. In the era of functional imaging, new advanced MRI sequences are being successfully applied for articular evaluation in cases of inflammatory, infectious, and degenerative arthropathies. Diffusion weighted imaging, new fat suppression techniques such as DIXON, dynamic contrast enhanced-MRI, and specific T2 mapping cartilage sequences allow a better understanding of the physiopathological processes that underlie these different arthropathies...
September 18, 2017: World Journal of Orthopedics
https://www.readbyqxmd.com/read/28978094/dna-repair-deregulation-in-discrete-prostate-cancer-lesions-identified-on-multi-parametric-mri-and-targeted-by-mri-ultrasound-fusion-guided-biopsy
#16
Caleb R Dulaney, Soroush Rais-Bahrami, Debra Della Manna, Jennifer B Gordetsky, Jeffrey W Nix, Eddy S Yang
Prostate cancer is histologically and molecularly heterogeneous. Clinically significant disease is often driven by dominant intra-prostatic lesions (IPLs). Prostate cancers cluster into molecular phenotypes with substantial genetic heterogeneity making pathway-based molecular analysis appealing. MRI/ultrasound fusion biopsy provides a unique opportunity to characterize tumor biology of discrete lesions at diagnosis. This study determined the feasibility of pathway-based gene expression analysis of prostate biopsies and characterized cancer pathway deregulation...
September 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28977973/multiparametric-imaging-using-18-f-fdg-pet-ct-heterogeneity-parameters-and-functional-mri-techniques-prognostic-significance-in-patients-with-primary-advanced-oropharyngeal-or-hypopharyngeal-squamous-cell-carcinoma-treated-with-chemoradiotherapy
#17
Sheng-Chieh Chan, Nai-Ming Cheng, Chia-Hsun Hsieh, Shu-Hang Ng, Chien-Yu Lin, Tzu-Chen Yen, Cheng-Lung Hsu, Hung-Ming Wan, Chun-Ta Liao, Kai-Ping Chang, Jiun-Jie Wang
BACKGROUND: In this study, PET heterogeneity was combined with functional MRI techniques to refine the prediction of prognosis in patients with oropharyngeal or hypopharyngeal squamous cell carcinoma (OHSCC). METHODS: A total of 124 patients with primary advanced OHSCC who underwent pretreatment (18)F-FDG PET/CT, dynamic contrast-enhanced MR imaging (DCE-MRI), and diffusion-weighted MR imaging (DWI) were enrolled. Conventional and heterogeneity parameters from (18)F-FDG PET as well as perfusion parameters from DCE-MRI and diffusion parameter from DWI of primary tumors were analyzed in relation to recurrence-free survival (RFS) and overall survival (OS)...
September 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28977682/mri-to-predict-nipple-areola-complex-nac-involvement-an-automatic-method-to-compute-the-3d-distance-between-the-nac-and-tumor
#18
Valentina Giannini, Veronica Bianchi, Silvia Carabalona, Simone Mazzetti, Furio Maggiorotto, Franziska Kubatzki, Daniele Regge, Riccardo Ponzone, Laura Martincich
OBJECTIVES: To assess the role in predicting nipple-areola complex (NAC) involvement of a newly developed automatic method which computes the 3D tumor-NAC distance. PATIENTS AND METHODS: Ninety-nine patients scheduled to nipple sparing mastectomy (NSM) underwent magnetic resonance (MR) examination at 1.5 T, including sagittal T2w and dynamic contrast enhanced (DCE)-MR imaging. An automatic method was developed to segment the NAC and the tumor and to compute the 3D distance between them...
October 4, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28963852/advanced-and-amplified-bold-fluctuations-in-high-grade-gliomas
#19
Lalit Gupta, Rakesh K Gupta, Alida A Postma, Prativa Sahoo, Pradeep K Gupta, Rana Patir, Sunita Ahlawat, Indrajit Saha, Walter H Backes
BACKGROUND: Glioma grade along with patient's age and general health are used for treatment planning and prognosis. PURPOSE: To characterize and quantify the spontaneous blood oxygen level-dependent (BOLD) fluctuations in gliomas using measures based on T2*-weighted signal time-series and to distinguish between high- and low-grade gliomas. STUDY TYPE: Retrospective. SUBJECTS: Twenty-one patients with high-grade and 13 patients with low-grade gliomas confirmed on histology were investigated...
September 30, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28963049/histogram-analysis-parameters-identify-multiple-associations-between-dwi-and-dce-mri-in-head-and-neck-squamous-cell-carcinoma
#20
Hans Jonas Meyer, Leonard Leifels, Stefan Schob, Nikita Garnov, Alexey Surov
OBJECTIVE: Nowadays, multiparametric investigations of head and neck squamous cell carcinoma (HNSCC) are established. These approaches can better characterize tumor biology and behavior. Diffusion weighted imaging (DWI) can by means of apparent diffusion coefficient (ADC) quantitatively characterize different tissue compartments. Dynamic contrast-enhanced magnetic resonance imaging (DCE MRI) reflects perfusion and vascularization of tissues. Recently, a novel approach of data acquisition, namely histogram analysis of different images is a novel diagnostic approach, which can provide more information of tissue heterogeneity...
September 28, 2017: Magnetic Resonance Imaging
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