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Dynamic contrasted enhance MRI

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https://www.readbyqxmd.com/read/28092414/dce-mri-of-the-prostate-using-shutter-speed-vs-tofts-model-for-tumor-characterization-and-assessment-of-aggressiveness
#1
Stefanie J Hectors, Cecilia Besa, Mathilde Wagner, Guido H Jajamovich, George K Haines, Sara Lewis, Ashutosh Tewari, Ardeshir Rastinehad, Wei Huang, Bachir Taouli
PURPOSE: To quantify Tofts model (TM) and shutter-speed model (SSM) perfusion parameters in prostate cancer (PCa) and noncancerous peripheral zone (PZ) and to compare the diagnostic performance of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) to Prostate Imaging and Reporting and Data System (PI-RADS) classification for the assessment of PCa aggressiveness. MATERIALS AND METHODS: Fifty PCa patients (mean age 60 years old) who underwent MRI at 3...
January 16, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28090589/spiral-perfusion-imaging-with-consecutive-echoes-spice%C3%A2-for-the-simultaneous-mapping-of-dsc-and-dce-mri-parameters-in-brain-tumor-patients-theory-and-initial-feasibility
#2
Eric S Paulson, Douglas E Prah, Kathleen M Schmainda
Dynamic contrast-enhanced (DCE) and dynamic susceptibility contrast (DSC) magnetic resonance imaging (MRI) are the perfusion imaging techniques most frequently used to probe the angiogenic character of brain neoplasms. With these methods, T1- and T2/T2*-weighted imaging sequences are used to image the distribution of gadolinium (Gd)-based contrast agents. However, it is well known that Gd exhibits combined T1, T2, and T2* shortening effects in tissue, and therefore, the results of both DCE- and DSC-MRI can be confounded by these opposing effects...
December 2016: Tomography: a Journal for Imaging Research
https://www.readbyqxmd.com/read/28088373/dynamic-contrast-enhanced-magnetic-resonance-imaging-dce-mri-for-the-prediction-of-non-union-consolidation
#3
Christian Fischer, Mareike Nissen, Gerhard Schmidmaier, Thomas Bruckner, Hans-Ulrich Kauczor, Marc-André Weber
INTRODUCTION: Non-union perfusion can be visualized with dynamic contrast-enhanced (DCE) MRI. This study evaluated DCE-MRI to predict non-union consolidation after surgery and detect factors that affect bone healing. MATERIALS AND METHODS: Between 2010 and 2015 non-union perfusion was prospectively quantified in 205 patients (mean age, 51.5 years, 129 men, 76 women) before intervention and at 6, 12, 26, 52 and more weeks follow-up. DCE-MRI results were related to the osseous consolidation, the ability to predict successful outcome was estimated by ROC analysis...
January 9, 2017: Injury
https://www.readbyqxmd.com/read/28088245/the-value-of-dynamic-contrast-enhanced-mri-in-characterizing-complex-ovarian-tumors
#4
Hai-Ming Li, Jin-Wei Qiang, Feng-Hua Ma, Shu-Hui Zhao
BACKGROUND: The study aimed to investigate the utility of dynamic contrast enhanced MRI (DCE-MRI) in the differentiation of malignant, borderline, and benign complex ovarian tumors. METHODS: DCE-MRI data of 102 consecutive complex ovarian tumors (benign 15, borderline 16, and malignant 71), confirmed by surgery and histopathology, were analyzed retrospectively. The patterns (I, II, and III) of time-signal intensity curve (TIC) and three semi-quantitative parameters, including enhancement amplitude (EA), maximal slope (MS), and time of half rising (THR), were evaluated and compared among benign, borderline, and malignant ovarian tumors...
January 14, 2017: Journal of Ovarian Research
https://www.readbyqxmd.com/read/28078795/a-continuous-infusion-dynamic-mri-model-at-3-0-tesla-for-the-serial-quantitative-evaluation-of-microvascular-proliferation-in-an-animal-model-of-glioblastoma-multiforme
#5
Hunter R Underhill
PURPOSE: To develop a continuous-infusion dynamic MRI technique to characterize tumor-associated microvascular proliferation (MVP) in a rat brain model of glioblastoma multiforme. METHODS: The proposed model assumes effects due to tumor-associated MVP (eg, vascular permeability, K(trans) ; intravascular plasma fraction, vp ) cannot be individually separated and solves for a single parameter (k(vasc) ) that quantifies the T1 -weighted contrast enhancement from dynamic images acquired during continuous contrast agent (CA) infusion...
January 12, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28078511/intra-individual-comparison-of-different-gadolinium-based-contrast-agents-in-the-quantitative-evaluation-of-c6-glioma-with-dynamic-contrast-enhanced-magnetic-resonance-imaging
#6
Ying Li, Gang Liu, Xin Lou, Zhiye Chen, Lin Ma
This experiment aimed to compare the ionic (Gadodiamide, Gd-DTPA-BMA) and non-ionic (Gadopentetate dimeglumine, Gd-DTPA) gadolinium-based contrast agents (GBCA) in the quantitative evaluation of C6 glioma with dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI). A C6 glioma model was established in 12 Wistar rats, and magnetic resonance (MR) scans were performed six days after tumor implantation. Imaging was performed using a 3.0-T MR scanner with a 7-inch handmade circular coil. Pre-contrast T1 mapping and dynamic contrast-enhanced T1WI after a bolus injection (0...
January 4, 2017: Science China. Life Sciences
https://www.readbyqxmd.com/read/28078508/prioritization-of-liver-mri-for-distinguishing-focal-lesions
#7
Qinghua Su, Shusheng Bi, Xuedong Yang
Liver cancer is one of the leading causes of cancer-related mortality worldwide. Magnetic resonance imaging (MRI) is a non-invasive imaging technique that is often used by radiologists for diagnosis and surgical planning. Analysis of a large amount of liver MRI data for each patient limits the radiologist's efficiency and may lead to misdiagnoses. The redundant MRI data, especially from dynamic contrast enhanced (DCE) sequences, is also a bottleneck in transmitting the images via the internet or PACS for remote consultancy in a reasonable amount of time...
January 4, 2017: Science China. Life Sciences
https://www.readbyqxmd.com/read/28075625/unenhanced-and-contrast-enhanced-mr-angiography-and-perfusion-imaging-for-suspected-pulmonary-thromboembolism
#8
Yoshiharu Ohno, Takeshi Yoshikawa, Yuji Kishida, Shinichiro Seki, Nevzat Karabulut
OBJECTIVE: This article discusses the basics of unenhanced MR angiography (MRA) and MR venography (MRV), time-resolved contrast-enhanced (CE) MRA and dynamic first-pass CE perfusion MRI, and unenhanced and CE MRV, in addition to assessing the clinical relevance of these techniques for evaluating patients with suspected pulmonary thromboembolism and deep venous thrombosis. CONCLUSION: Since the 1990s, the efficacy of MRA or MRV and dynamic perfusion MRI for patients with suspected pulmonary thromboembolism and deep venous thrombosis has been evaluated...
January 11, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28070841/reproducibility-of-dynamic-contrast-enhanced-mri-and-dynamic-susceptibility-contrast-mri-in-the-study-of-brain-gliomas-a-comparison-of-data-obtained-using-different-commercial-software
#9
Gian Marco Conte, Antonella Castellano, Luisa Altabella, Antonella Iadanza, Marcello Cadioli, Andrea Falini, Nicoletta Anzalone
PURPOSE: Dynamic susceptibility contrast MRI (DSC) and dynamic contrast-enhanced MRI (DCE) are useful tools in the diagnosis and follow-up of brain gliomas; nevertheless, both techniques leave the open issue of data reproducibility. We evaluated the reproducibility of data obtained using two different commercial software for perfusion maps calculation and analysis, as one of the potential sources of variability can be the software itself. METHODS: DSC and DCE analyses from 20 patients with gliomas were tested for both the intrasoftware (as intraobserver and interobserver reproducibility) and the intersoftware reproducibility, as well as the impact of different postprocessing choices [vascular input function (VIF) selection and deconvolution algorithms] on the quantification of perfusion biomarkers plasma volume (Vp), volume transfer constant (K (trans)) and rCBV...
January 9, 2017: La Radiologia Medica
https://www.readbyqxmd.com/read/28069337/erratum-to-non-palpable-incidentally-found-testicular-tumors-differentiation-between-benign-malignant-and-burned-out-tumors-using-dynamic-contrast-enhanced-mri-eur-j-radiol-85-11-2016-2072-2082
#10
Imane El Sanharawi, Jean-Michel Correas, Ludivine Glas, Sophie Ferlicot, Vincent Izard, Béatrice Ducot, Marie-France Bellin, Gérard Benoît, Laurence Rocher
No abstract text is available yet for this article.
January 6, 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28066808/effect-of-mr-imaging-contrast-thresholds-on-prediction-of-neoadjuvant-chemotherapy-response-in-breast-cancer-subtypes-a-subgroup-analysis-of-the-acrin-6657-i-spy-1-trial
#11
Wen Li, Vignesh Arasu, David C Newitt, Ella F Jones, Lisa Wilmes, Jessica Gibbs, John Kornak, Bonnie N Joe, Laura J Esserman, Nola M Hylton
Functional tumor volume (FTV) measurements by dynamic contrast-enhanced magnetic resonance imaging can predict treatment outcomes for women receiving neoadjuvant chemotherapy for breast cancer. Here, we explore whether the contrast thresholds used to define FTV could be adjusted by breast cancer subtype to improve predictive performance. Absolute FTV and percent change in FTV (ΔFTV) at sequential time-points during treatment were calculated and investigated as predictors of pathologic complete response at surgery...
December 2016: Tomography: a Journal for Imaging Research
https://www.readbyqxmd.com/read/28066805/evaluation-of-soft-tissue-sarcoma-response-to-preoperative-chemoradiotherapy-using-dynamic-contrast-enhanced-magnetic-resonance-imaging
#12
Wei Huang, Brooke R Beckett, Alina Tudorica, Janelle M Meyer, Aneela Afzal, Yiyi Chen, Atiya Mansoor, James B Hayden, Yee-Cheen Doung, Arthur Y Hung, Megan L Holtorf, Torrie J Aston, Christopher W Ryan
This study aims to assess the utility of quantitative dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) parameters in comparison with imaging tumor size for early prediction and evaluation of soft tissue sarcoma response to preoperative chemoradiotherapy. In total, 20 patients with intermediate- to high-grade soft tissue sarcomas received either a phase I trial regimen of sorafenib + chemoradiotherapy (n = 8) or chemoradiotherapy only (n = 12), and underwent DCE-MRI at baseline, after 2 weeks of treatment with sorafenib or after the first chemotherapy cycle, and after therapy completion...
December 2016: Tomography: a Journal for Imaging Research
https://www.readbyqxmd.com/read/28065695/perfusion-of-the-uterine-junctional-zone-in-nulliparous-and-primiparous-women-assessed-by-dce-mri-as-a-function-of-menstrual-cycle-and-hormonal-contraception
#13
L J Meylaerts, L Wijnen, M Bazot, M Grieten, W Ombelet, M Vandersteen
PURPOSE: To evaluate the perfusion parameters of inner and outer myometrium in healthy nulliparous and primiparous women who are and who are not currently using hormonal contraceptives by means of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI). MATERIAL AND METHODS: We performed pelvic 1.5T DCE-MRI on 98 women: 18 nulliparous non-users, 30 nulliparous users, 12 primiparous non-users and 38 primiparous users of hormonal contraception (mean age respectively 26...
January 6, 2017: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/28063355/orbital-oncocytoma-evaluation-with-dynamic-contrast-enhanced-magnetic-resonance-imaging-using-a-time-signal-intensity-curve-and-positive-enhancement-integral-images
#14
Nutchawan Jittapiromsak, Ping Hou, Michelle D Williams, T Linda Chi
Oncocytomas, which are benign epithelial tumors filled with abundant mitochondria, arise from ductal cells. Oncocytomas rarely occur in the orbit. We present a case of pathologically proven orbital oncocytoma of the lacrimal gland studied by dynamic contrast-enhanced magnetic resonance imaging (DCE MRI). DCE MRI has potential as an adjunct to conventional MRI in the differential diagnosis and tumor margin delineation of orbital oncocytoma. Simple assessments of the time-signal intensity curve, semiquantitative parameters, and post-processing positive enhancement integral images should be considered in the evaluation of orbital masses found on MRI...
December 6, 2016: Clinical Imaging
https://www.readbyqxmd.com/read/28060884/contrast-enhanced-ultrasound-with-vegfr2-targeted-microbubbles-for-monitoring-regorafenib-therapy-effects-in-experimental-colorectal-adenocarcinomas-in-rats-with-dce-mri-and-immunohistochemical-validation
#15
Ralf Stefan Eschbach, Dirk-Andre Clevert, Heidrun Hirner-Eppeneder, Michael Ingrisch, Matthias Moser, Jessica Schuster, Dina Tadros, Moritz Schneider, Philipp Maximilian Kazmierczak, Maximilian Reiser, Clemens C Cyran
OBJECTIVES: To investigate contrast-enhanced ultrasound (CEUS) with VEGFR2-targeted microbubbles for monitoring therapy effects of regorafenib on experimental colon carcinomas in rats with correlation to dynamic contrast-enhanced MRI (DCE-MRI) and immunohistochemistry. MATERIALS AND METHODS: Human colorectal adenocarcinoma xenografts (HT-29) were implanted subcutaneously in n = 21 (n = 11 therapy group; n = 10 control group) female athymic nude rats (Hsd: RH-Foxn1rnu)...
2017: PloS One
https://www.readbyqxmd.com/read/28055248/review-article-functional-mri-for-quantitative-treatment-response-prediction-in-locally-advanced-rectal-cancer
#16
Trang T Pham, Gary P Liney, Karen Wong, Michael B Barton
Despite advances in multi-modality treatment strategies for locally advanced rectal cancer and improvements in loco-regional control, there is still a considerable variation in response to neo-adjuvant chemo-radiotherapy (CRT). Accurate prediction of response to neo-adjuvant CRT would enable early stratification of management according to good responders and poor responders, in order to adapt treatment to improve therapeutic outcomes in rectal cancer. Clinical studies in diffusion weighted imaging (DWI) and dynamic contrast enhanced (DCE) MRI have shown promising results for the prediction of therapeutic response in rectal cancer...
January 5, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28050622/correlation-between-quantitative-and-semiquantitative-parameters-in-dce-mri-with-a-blood-pool-agent-in-rectal-cancer-can-semiquantitative-parameters-be-used-as-a-surrogate-for-quantitative-parameters
#17
Rebecca A P Dijkhoff, Monique Maas, Milou H Martens, Nikolaos Papanikolaou, Doenja M J Lambregts, Geerard L Beets, Regina G H Beets-Tan
PURPOSE: The aim of this study was to assess correlation between quantitative and semiquantitative parameters in dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) in rectal cancer patients, both in a primary staging and restaging setting. MATERIALS AND METHODS: Nineteen patients were included with DCE-MRI before and/or after neoadjuvant therapy. DCE-MRI was performed with gadofosveset trisodium (Ablavar(®), Lantheus Medical Imaging, North Billerica, Massachusetts, USA)...
January 3, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/28048511/su-d-207a-02-possible-characterization-of-the-brain-tumor-vascular-environment-by-a-novel-strategy-of-quantitative-analysis-in-dynamic-contrast-enhanced-mr-imaging-a-combination-of-both-patlak-and-logan-analyses
#18
S Yee, P Chinnaiyan, J Wloch, M Pirkola, D Yan
PURPOSE: The majority of quantitative analyses involving dynamic contrast enhanced (DCE) MRI have been performed to obtain kinetic parameters such as Ktrans and ve. Such analyses are generally performed assuming a "reversible" tissue compartment, where the tracer is assumed to be rapidly equilibrated between the plasma and tissue compartments. However, some tumor vascular environments may be more suited for a "non-reversible" tissue compartment, where, as with FDG PET imaging, the tracer is continuously deposited into the tissue compartment (or the return back to the plasma compartment is very slow in the imaging time scale)...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048388/su-f-r-16-delineation-of-tumor-habitats-based-on-dynamic-contrast-enhanced-mri
#19
Y Chang, G Solorzano, E Ackerstaff, R Yechieli, T Subhawong, R Stoyanova
PURPOSE: To determine an automatic procedure for determining the number and delineation of tumor habitats from Dynamic Contrast Enhanced (DCE) MRI data. METHODS: An automatic procedure for delineation of tumor habitats from DCE-MRI datasets was developed as a two-part process involving: (1) statistical testing of the principal components of the dataset to detect the number of habitats and (2) the use of this number in an unsupervised pattern recognition (PR) technique to recover the temporal pattern and location of detected habitats...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048384/su-d-207b-06-predicting-breast-cancer-malignancy-on-dce-mri-data-using-pre-trained-convolutional-neural-networks
#20
N Antropova, B Huynh, M Giger
PURPOSE: We investigate deep learning in the task of distinguishing between malignant and benign breast lesions on dynamic contrast-enhanced MR images (DCE-MRIs), eliminating the need for lesion segmentation and extraction of tumor features. We evaluate convolutional neural network (CNN) after transfer learning with ImageNet, a database of thousands of non-medical images. METHODS: Under a HIPAA-compliant IRB protocol, a database of 551 (357 malignant and 194 benign) breast MRI cases was collected...
June 2016: Medical Physics
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