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Intraplaque neovascularization carotid

Ru Ying, Sheng-Wei Li, Jia-Yuan Chen, Hai-Feng Zhang, Ying Yang, Zhen-Jie Gu, Yang-Xin Chen, Jing-Feng Wang
BACKGROUND: Perivascular adipose tissue (PVAT) accelerates plaque progression and increases cardiovascular risk. We tested the hypothesis that PVAT contributed to plaque vulnerability and investigated whether endoplasmic reticulum stress (ER stress) in PVAT played an important role in vulnerable plaque. METHODS: We transplanted thoracic aortic PVAT or subcutaneous adipose tissue as a control, from donor mice to carotid arteries of recipient apolipoprotein E deficient (apoE-/- ) mice after removing carotid artery collar placed for 6 weeks...
April 18, 2018: Journal of Translational Medicine
Yasuyoshi Shimada, Kohki Oikawa, Shunrou Fujiwara, Yasushi Ogasawara, Yuiko Sato, Shinsuke Narumi, Tadayoshi Kato, Kazumasa Oura, Yasuo Terayama, Makoto Sasaki, Kentaro Fujimoto, Jun Yoshida, Kuniaki Ogasawara
BACKGROUND AND PURPOSE: Magnetic resonance (MR) and contrast-enhanced ultrasound assess characteristics and neovascularization, respectively, of the carotid plaque. The purpose of the present study was to clarify how findings of contrast-enhanced ultrasound plaque imaging are related to those of 3-dimensional (3D) fast spin echo (FSE) T1-weighted MR plaque imaging (WI) in severe stenosis (≥70%) of the cervical carotid artery. METHODS: Fifty-three patients underwent 3D FSE T1-WI and contrast-enhanced ultrasound...
September 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
Vasileios Rafailidis, Afroditi Charitanti, Thomas Tegos, Evangelos Destanis, Ioannis Chryssogonidis
Carotid disease is a major current health problem accounting for a significant part of stroke patients. Ultrasound with colour Doppler and spectral analysis is the primary imaging technique used for screening and diagnostic evaluation of the extracranial part of carotid arteries offering identification and grading of carotid disease. However, inherent limitations of this technique include flow-related artefacts like Doppler angle dependence and aliasing artefact which may sometimes hinder complete assessment of a stenotic part of the vessel, potentially failing to address clinically significant differential diagnosis issues...
June 2017: Journal of Ultrasound
Fabian Demeure, Caroline Bouzin, Véronique Roelants, Anne Bol, Robert Verhelst, Parla Astarci, Bernhard L Gerber, Anne-Catherine Pouleur, Agnès Pasquet, Christophe de Meester, Jean-Louis J Vanoverschelde, David Vancraeynest
BACKGROUND: Inflammation and intraplaque neovascularization are acknowledged to be 2 features of plaque vulnerability, although their temporal expression and their respective value in predicting clinical events are poorly understood. To determine their respective temporal associations, we conducted a comprehensive assessment of inflammation and intraplaque neovascularization in the carotid plaque of symptomatic and asymptomatic patients. METHODS AND RESULTS: Thirty patients with severe carotid stenosis underwent 18F-fluorodeoxyglucose-positron emission tomography/computed tomographic imaging...
May 2017: Circulation. Cardiovascular Imaging
Caroline Camaré, Corinne Vanucci-Bacqué, Nathalie Augé, Mélanie Pucelle, Corinne Bernis, Audrey Swiader, Michel Baltas, Florence Bedos-Belval, Robert Salvayre, Anne Nègre-Salvayre
The neovascularization of atherosclerotic lesions is involved in plaque development and may contribute to intraplaque hemorrhage and plaque fragilization and rupture. Among the various proangiogenic agents involved in the neovascularization process, proatherogenic oxidized LDLs (oxLDLs) contribute to the formation of tubes via the generation of sphingosine 1-phosphate (S1P), a major mitogenic and proangiogenic sphingolipid mediator. In this study, we investigated whether 4-hydroxynonenal (4-HNE), an aldehydic lipid oxidation product abundantly present in oxLDLs, contributes to their proangiogenic properties...
2017: Oxidative Medicine and Cellular Longevity
Charlotte Schmidt, Thomas Fischer, Ralph-Ingo Rückert, Timm Oberwahrenbrock, Lutz Harms, Golo Kronenberg, Hagen Kunte
BACKGROUND: Plaque neovascularization accompanies local inflammation and critically contributes to plaque instability. Correct identification of intraplaque neovascularization by contrast-enhanced ultrasound (CEUS) may provide an additional risk marker in carotid stenosis. This pilot study investigates the correlation between histological evaluation of carotid plaque specimens and pre-surgery CEUS to identify neovascularization. METHODS: 17 patients with high-grade internal carotid artery (ICA) stenosis were studied...
2017: PloS One
Beibei Sun, Huilin Zhao, Xiao Li, Hong Yao, Xiaosheng Liu, Qing Lu, Jieqing Wan, Jianrong Xu
This study sought to reveal the effect of angiotensin II (Ang II)-induced atherosclerotic vulnerability in rabbits and to determine whether in vivo magnetic resonance imaging (MRI) can determine the effect of Ang II on atherosclerotic development over time. In total, 24 elderly male New Zealand white rabbits underwent an intravascular balloon injury in the left common carotid artery (LCCA) and were subsequently fed a high cholesterol diet for 12 weeks. At 8 weeks, rabbits were randomly assigned to receive either Ang II (1...
March 2017: Saudi Journal of Biological Sciences
Mattia Cattaneo, Daniel Staub, Alessandra P Porretta, Jeanne Marie Gallino, Paolo Santini, Costanzo Limoni, Rolf Wyttenbach, Augusto Gallino
Here we provide the correlation among different carotid ultrasound (US) variables to assess echogenicity n standard carotid US and to assess intraplaque neovascularization on contrast enhanced US. We recruited 45 consecutive subjects with an asymptomatic≥50% carotid artery stenosis. Carotid plaque echogenicity at standard US was visually graded according to Gray-Weale classification (GW) and measured by the greyscale median (GSM), a semi-automated computerized measurement performed by Adobe Photoshop®. On CEUS imaging IPNV was graded according to the visual appearance of contrast within the plaque according to three different methods: CEUS_A (1=absent; 2=present); CEUS_B a three-point scale (increasing IPNV from 1 to 3); CEUS_C a four-point scale (increasing IPNV from 0 to 3)...
December 2016: Data in Brief
Thorsten Derlin, Johannes Thiele, Desiree Weiberg, James T Thackeray, Klaus Püschel, Hans-Jürgen Wester, Lukas Aguirre Dávila, Axel Larena-Avellaneda, Günter Daum, Frank M Bengel, Udo Schumacher
OBJECTIVE: Intraplaque neovascularization contributes to the progression and rupture of atherosclerotic lesions. Glutamate carboxypeptidase II (GCPII) is strongly expressed by endothelial cells of tumor neovasculature and plays a major role in hypoxia-induced neovascularization in rodent models of benign diseases. We hypothesized that GCPII expression may play a role in intraplaque neovascularization and may represent a target for imaging of atherosclerotic lesions. The aim of this study was to determine frequency, pattern, and clinical correlates of vessel wall uptake of a (68)Ga-GCPII ligand for positron emission tomographic imaging...
November 2016: Arteriosclerosis, Thrombosis, and Vascular Biology
Mattia Cattaneo, Daniel Staub, Alessandra P Porretta, Jeanne Marie Gallino, Paolo Santini, Costanzo Limoni, Rolf Wyttenbach, Augusto Gallino
BACKGROUND: Currently the most widely accepted predictor of stroke risk in patients with carotid atherosclerosis is the degree of stenoses. Plaque echogenicity on ultrasound imaging (US) and intraplaque neovascularization (IPNV) are becoming recognized as factors of plaque vulnerability. Aim of the study was to investigate the correlation between the echogenicity of the carotid atherosclerosis by standard US and the degree of IPNV by contrast enhanced US (CEUS). METHODS: We recruited 45 consecutive subjects with an asymptomatic ≥50% carotid artery stenoses...
November 15, 2016: International Journal of Cardiology
Konstantinos Filis, Levon Toufektzian, George Galyfos, Fragiska Sigala, Panagiota Kourkoveli, Sotirios Georgopoulos, Manolis Vavuranakis, Dimitrios Vrachatis, George Zografos
Carotid atherosclerosis represents a primary cause for cerebrovascular ischemic events and its contemporary management includes surgical revascularization for moderate to severe symptomatic stenoses. However, the role of invasive therapy seems to be questioned lately for asymptomatic cases. Numerous reports have suggested that the presence of neovessels within the atherosclerotic plaque remains a significant vulnerability factor and over the last decade imaging modalities have been used to identify intraplaque neovascularization in an attempt to risk-stratify patients and offer management guidance...
June 2017: Vascular
Benoy N Shah, Dorothy M Gujral, Navtej S Chahal, Kevin J Harrington, Christopher M Nutting, Roxy Senior
OBJECTIVES: The aim of this study was to determine the effect of radiotherapy (RT) on intraplaque neovascularization (IPN) in human carotid arteries. BACKGROUND: Exposure of the carotid arteries to RT during treatment for head and neck cancer is associated with increased risk for stroke. However, the effect of RT on IPN, a precursor to intraplaque hemorrhage and thus associated with plaque vulnerability, is unknown. METHODS: In this cross-sectional study, patients who had undergone unilateral RT for head and neck cancer ≥2 years previously underwent B-mode and contrast-enhanced ultrasound of both RT-side and non-RT-side carotid arteries...
June 2016: JACC. Cardiovascular Imaging
Runqing Huang, Sahar S Abdelmoneim, Caroline A Ball, Lara F Nhola, Ann M Farrell, Steven Feinstein, Sharon L Mulvagh
BACKGROUND: Intraplaque neovascularization is considered an important indicator of plaque vulnerability. Contrast-enhanced ultrasound (CEUS) of carotid arteries improves imaging of carotid intima-media thickness and permits real-time visualization of neovascularization of the atherosclerotic plaque. The authors conducted a systematic review and meta-analysis to evaluate the accuracy of CEUS-detected carotid atherosclerotic plaque. METHODS: A systematic search was performed to identify studies published in the MEDLINE, Embase, Scopus, and Web of Science databases from 2004 to June 2015...
June 2016: Journal of the American Society of Echocardiography
Daina Kashiwazaki, Naoki Akioka, Naoya Kuwayama, Tomohide Hayashi, Kyo Noguchi, Kortaro Tanaka, Satoshi Kuroda
OBJECTIVE The roles of endothelial progenitor cells (EPCs) in the development of carotid plaque are still obscure. This study aimed to clarify this by assessing the histological findings of specimens obtained from carotid endarterectomy. METHODS This study included 34 patients who underwent carotid endarterectomy. MR imaging was performed to semiquantitatively analyze the components of the carotid plaques in all patients. The surgical specimens were subjected to immunohistochemistry. The distributions of the CD34-, CD133-, VEGF-2R-positive cells in the carotid plaques were precisely analyzed, and their number was quantified...
December 2016: Journal of Neurosurgery
Remco A Haasdijk, Wijnand K Den Dekker, Caroline Cheng, Dennie Tempel, Robert Szulcek, Frank L Bos, Dorien M A Hermkens, Ihsan Chrifi, Maarten M Brandt, Chris Van Dijk, Yan Juan Xu, Esther H M Van De Kamp, Lau A J Blonden, Jan Van Bezu, Judith C Sluimer, Erik A L Biessen, Geerten P Van Nieuw Amerongen, Henricus J Duckers
AIMS: Impairment of the endothelial barrier leads to microvascular breakdown in cardiovascular disease and is involved in intraplaque haemorrhaging and the progression of advanced atherosclerotic lesions that are vulnerable to rupture. The exact mechanism that regulates vascular integrity requires further definition. Using a microarray screen for angiogenesis-associated genes during murine embryogenesis, we identified thrombospondin type I domain 1 (THSD1) as a new putative angiopotent factor with unknown biological function...
May 1, 2016: Cardiovascular Research
Jian-Hua Qiao, Vivek Mishra, Michael C Fishbein, Satyesh K Sinha, Tripathi B Rajavashisth
UNLABELLED: The mechanism(s) mediating atherosclerotic calcification may be similar to those governing bone remodeling, and osteoblast-like cells have been observed in plaque. We tested the hypothesis that osteoclast-like cells (OLCs) also exist in atherosclerotic arteries. In 205 tissue blocks obtained from 21 patients undergoing carotid endarterectomy, we performed histopathologic analysis, histochemical staining for tartrate-resistant acid phosphatase (TRAP), and immunohistochemical analysis for osteoclast and macrophage antigens, including CD68, colony stimulating factor-1 receptor (CSF-1R), cathepsin K (cat-K), receptor activator of nuclear factor-κB (RANK), and osteoprotegerin (OPG)...
December 2015: Experimental and Molecular Pathology
C R Gomez, R T Kubiniec, J B Wade, C Bedrossian
Carotid artery surgical specimens from 15 consecutive patients undergoing carotid endarterectomy were studied in an attempt to identify morphologic differences between carotid artery plaque neovascularization (NV) and normal vasa vasorum (VV). The patients included 12 men and 3 women with an age range of 55-81 years (mean, 67). Nine of them had ischemic symptoms directly related to the plaque being removed. The specimens were stained with hematoxylin-eosin, Verhoef-Van Gieson, and factor VIII-related antigen techniques...
1992: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
Waleed Brinjikji, Alejandro A Rabinstein, Giuseppe Lanzino, Mohammad H Murad, Eric E Williamson, J Kevin DeMarco, John Huston
BACKGROUND: Ultrasound is the most commonly used imaging modality for assessing carotid artery stenosis. A number of studies have demonstrated that surface irregularities, heterogeneous echotexture and hypoechoic plaques are risk factors for acute ischemic stroke. We performed a systematic review and meta-analysis of the literature to better define the risk of stroke based on the sonographic characteristics of carotid plaques. MATERIALS AND METHODS: We performed a comprehensive search for studies reporting imaging findings of symptomatic and asymptomatic carotid plaques on ultrasound using MEDLINE and EMBASE...
2015: Cerebrovascular Diseases
Waleed Brinjikji, John Huston, Alejandro A Rabinstein, Gyeong-Moon Kim, Amir Lerman, Giuseppe Lanzino
Carotid artery stenosis is a well-established risk factor of ischemic stroke, contributing to up to 10%-20% of strokes or transient ischemic attacks. Many clinical trials over the last 20 years have used measurements of carotid artery stenosis as a means to risk stratify patients. However, with improvements in vascular imaging techniques such as CT angiography and MR angiography, ultrasonography, and PET/CT, it is now possible to risk stratify patients, not just on the degree of carotid artery stenosis but also on how vulnerable the plaque is to rupture, resulting in ischemic stroke...
January 2016: Journal of Neurosurgery
Q Zhang, C Li, H Han, W Dai, J Shi, Y Wang, W Wang
OBJECTIVE/BACKGROUND: To evaluate whether carotid intraplaque neovascularization (IPN) can be accurately assessed by two types of quantitative analysis on contrast enhanced ultrasound (CEUS), the time intensity curve analysis and the analysis of contrast agent spatial distributions, and whether the quantitative analysis correlates with semiquantitative visual interpretation and histopathology. METHODS: Forty-four plaques in 34 patients were included for CEUS examination...
September 2015: European Journal of Vascular and Endovascular Surgery
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