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Intraplaque neovascularization carotid

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https://www.readbyqxmd.com/read/27752526/data-on-consistency-among-different-methods-to-assess-atherosclerotic-plaque-echogenicity-on-standard-ultrasound-and-intraplaque-neovascularization-on-contrast-enhanced-ultrasound-imaging-in-human-carotid-artery
#1
Mattia Cattaneo, Daniel Staub, Alessandra P Porretta, Jeanne Marie Gallino, Paolo Santini, Costanzo Limoni, Rolf Wyttenbach, Augusto Gallino
Here we provide the correlation among different carotid ultrasound (US) variables to assess echogenicity n standard carotid US and to assess intraplaque neovascularization on contrast enhanced US. We recruited 45 consecutive subjects with an asymptomatic≥50% carotid artery stenosis. Carotid plaque echogenicity at standard US was visually graded according to Gray-Weale classification (GW) and measured by the greyscale median (GSM), a semi-automated computerized measurement performed by Adobe Photoshop(®)...
December 2016: Data in Brief
https://www.readbyqxmd.com/read/27609368/evaluation-of-68ga-glutamate-carboxypeptidase-ii-ligand-positron-emission-tomography-for-clinical-molecular-imaging-of-atherosclerotic-plaque-neovascularization
#2
Thorsten Derlin, Johannes Thiele, Desiree Weiberg, James T Thackeray, Klaus Püschel, Hans-Jürgen Wester, Lukas Aguirre Dávila, Axel Larena-Avellaneda, Günter Daum, Frank M Bengel, Udo Schumacher
OBJECTIVE: Intraplaque neovascularization contributes to the progression and rupture of atherosclerotic lesions. Glutamate carboxypeptidase II (GCPII) is strongly expressed by endothelial cells of tumor neovasculature and plays a major role in hypoxia-induced neovascularization in rodent models of benign diseases. We hypothesized that GCPII expression may play a role in intraplaque neovascularization and may represent a target for imaging of atherosclerotic lesions. The aim of this study was to determine frequency, pattern, and clinical correlates of vessel wall uptake of a (68)Ga-GCPII ligand for positron emission tomographic imaging...
September 8, 2016: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/27597156/contrast-enhanced-ultrasound-imaging-of-intraplaque-neovascularization-and-its-correlation-to-plaque-echogenicity-in-human-carotid-arteries-atherosclerosis
#3
Mattia Cattaneo, Daniel Staub, Alessandra P Porretta, Jeanne Marie Gallino, Paolo Santini, Costanzo Limoni, Rolf Wyttenbach, Augusto Gallino
BACKGROUND: Currently the most widely accepted predictor of stroke risk in patients with carotid atherosclerosis is the degree of stenoses. Plaque echogenicity on ultrasound imaging (US) and intraplaque neovascularization (IPNV) are becoming recognized as factors of plaque vulnerability. Aim of the study was to investigate the correlation between the echogenicity of the carotid atherosclerosis by standard US and the degree of IPNV by contrast enhanced US (CEUS). METHODS: We recruited 45 consecutive subjects with an asymptomatic ≥50% carotid artery stenoses...
November 15, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27580821/assessment-of-the-vulnerable-carotid-atherosclerotic-plaque-using-contrast-enhanced-ultrasonography
#4
Konstantinos Filis, Levon Toufektzian, George Galyfos, Fragiska Sigala, Panagiota Kourkoveli, Sotirios Georgopoulos, Manolis Vavuranakis, Dimitrios Vrachatis, George Zografos
Carotid atherosclerosis represents a primary cause for cerebrovascular ischemic events and its contemporary management includes surgical revascularization for moderate to severe symptomatic stenoses. However, the role of invasive therapy seems to be questioned lately for asymptomatic cases. Numerous reports have suggested that the presence of neovessels within the atherosclerotic plaque remains a significant vulnerability factor and over the last decade imaging modalities have been used to identify intraplaque neovascularization in an attempt to risk-stratify patients and offer management guidance...
August 31, 2016: Vascular
https://www.readbyqxmd.com/read/27209103/plaque-neovascularization-is-increased-in%C3%A2-human-carotid-atherosclerosis-related%C3%A2-to-prior-neck-radiotherapy-a-contrast-enhanced-ultrasound-study
#5
Benoy N Shah, Dorothy M Gujral, Navtej S Chahal, Kevin J Harrington, Christopher M Nutting, Roxy Senior
OBJECTIVES: The aim of this study was to determine the effect of radiotherapy (RT) on intraplaque neovascularization (IPN) in human carotid arteries. BACKGROUND: Exposure of the carotid arteries to RT during treatment for head and neck cancer is associated with increased risk for stroke. However, the effect of RT on IPN, a precursor to intraplaque hemorrhage and thus associated with plaque vulnerability, is unknown. METHODS: In this cross-sectional study, patients who had undergone unilateral RT for head and neck cancer ≥2 years previously underwent B-mode and contrast-enhanced ultrasound of both RT-side and non-RT-side carotid arteries...
June 2016: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/27038513/detection-of-carotid-atherosclerotic-plaque-neovascularization-using-contrast-enhanced-ultrasound-a-systematic-review-and-meta-analysis-of-diagnostic-accuracy-studies
#6
REVIEW
Runqing Huang, Sahar S Abdelmoneim, Caroline A Ball, Lara F Nhola, Ann M Farrell, Steven Feinstein, Sharon L Mulvagh
BACKGROUND: Intraplaque neovascularization is considered an important indicator of plaque vulnerability. Contrast-enhanced ultrasound (CEUS) of carotid arteries improves imaging of carotid intima-media thickness and permits real-time visualization of neovascularization of the atherosclerotic plaque. The authors conducted a systematic review and meta-analysis to evaluate the accuracy of CEUS-detected carotid atherosclerotic plaque. METHODS: A systematic search was performed to identify studies published in the MEDLINE, Embase, Scopus, and Web of Science databases from 2004 to June 2015...
June 2016: Journal of the American Society of Echocardiography
https://www.readbyqxmd.com/read/26871204/involvement-of-circulating-endothelial-progenitor-cells-in-carotid-plaque-growth-and-vulnerability
#7
Daina Kashiwazaki, Naoki Akioka, Naoya Kuwayama, Tomohide Hayashi, Kyo Noguchi, Kortaro Tanaka, Satoshi Kuroda
OBJECTIVE The roles of endothelial progenitor cells (EPCs) in the development of carotid plaque are still obscure. This study aimed to clarify this by assessing the histological findings of specimens obtained from carotid endarterectomy. METHODS This study included 34 patients who underwent carotid endarterectomy. MR imaging was performed to semiquantitatively analyze the components of the carotid plaques in all patients. The surgical specimens were subjected to immunohistochemistry. The distributions of the CD34-, CD133-, VEGF-2R-positive cells in the carotid plaques were precisely analyzed, and their number was quantified...
December 2016: Journal of Neurosurgery
https://www.readbyqxmd.com/read/26822228/thsd1-preserves-vascular-integrity-and-protects-against-intraplaque-haemorrhaging-in-apoe-mice
#8
Remco A Haasdijk, Wijnand K Den Dekker, Caroline Cheng, Dennie Tempel, Robert Szulcek, Frank L Bos, Dorien M A Hermkens, Ihsan Chrifi, Maarten M Brandt, Chris Van Dijk, Yan Juan Xu, Esther H M Van De Kamp, Lau A J Blonden, Jan Van Bezu, Judith C Sluimer, Erik A L Biessen, Geerten P Van Nieuw Amerongen, Henricus J Duckers
AIMS: Impairment of the endothelial barrier leads to microvascular breakdown in cardiovascular disease and is involved in intraplaque haemorrhaging and the progression of advanced atherosclerotic lesions that are vulnerable to rupture. The exact mechanism that regulates vascular integrity requires further definition. Using a microarray screen for angiogenesis-associated genes during murine embryogenesis, we identified thrombospondin type I domain 1 (THSD1) as a new putative angiopotent factor with unknown biological function...
May 1, 2016: Cardiovascular Research
https://www.readbyqxmd.com/read/26551087/multinucleated-giant-cells-in-atherosclerotic-plaques-of-human-carotid-arteries-identification-of-osteoclast-like-cells-and-their-specific-proteins-in-artery-wall
#9
Jian-Hua Qiao, Vivek Mishra, Michael C Fishbein, Satyesh K Sinha, Tripathi B Rajavashisth
UNLABELLED: The mechanism(s) mediating atherosclerotic calcification may be similar to those governing bone remodeling, and osteoblast-like cells have been observed in plaque. We tested the hypothesis that osteoclast-like cells (OLCs) also exist in atherosclerotic arteries. In 205 tissue blocks obtained from 21 patients undergoing carotid endarterectomy, we performed histopathologic analysis, histochemical staining for tartrate-resistant acid phosphatase (TRAP), and immunohistochemical analysis for osteoclast and macrophage antigens, including CD68, colony stimulating factor-1 receptor (CSF-1R), cathepsin K (cat-K), receptor activator of nuclear factor-κB (RANK), and osteoprotegerin (OPG)...
December 2015: Experimental and Molecular Pathology
https://www.readbyqxmd.com/read/26486427/immunohistochemistry-of-carotid-plaque-neovascularization-and-vasa-vasorum
#10
C R Gomez, R T Kubiniec, J B Wade, C Bedrossian
Carotid artery surgical specimens from 15 consecutive patients undergoing carotid endarterectomy were studied in an attempt to identify morphologic differences between carotid artery plaque neovascularization (NV) and normal vasa vasorum (VV). The patients included 12 men and 3 women with an age range of 55-81 years (mean, 67). Nine of them had ischemic symptoms directly related to the plaque being removed. The specimens were stained with hematoxylin-eosin, Verhoef-Van Gieson, and factor VIII-related antigen techniques...
1992: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/26279159/ultrasound-characteristics-of-symptomatic-carotid-plaques-a-systematic-review-and-meta-analysis
#11
REVIEW
Waleed Brinjikji, Alejandro A Rabinstein, Giuseppe Lanzino, Mohammad H Murad, Eric E Williamson, J Kevin DeMarco, John Huston
BACKGROUND: Ultrasound is the most commonly used imaging modality for assessing carotid artery stenosis. A number of studies have demonstrated that surface irregularities, heterogeneous echotexture and hypoechoic plaques are risk factors for acute ischemic stroke. We performed a systematic review and meta-analysis of the literature to better define the risk of stroke based on the sonographic characteristics of carotid plaques. MATERIALS AND METHODS: We performed a comprehensive search for studies reporting imaging findings of symptomatic and asymptomatic carotid plaques on ultrasound using MEDLINE and EMBASE...
2015: Cerebrovascular Diseases
https://www.readbyqxmd.com/read/26230478/contemporary-carotid-imaging-from-degree-of-stenosis-to-plaque-vulnerability
#12
REVIEW
Waleed Brinjikji, John Huston, Alejandro A Rabinstein, Gyeong-Moon Kim, Amir Lerman, Giuseppe Lanzino
Carotid artery stenosis is a well-established risk factor of ischemic stroke, contributing to up to 10%-20% of strokes or transient ischemic attacks. Many clinical trials over the last 20 years have used measurements of carotid artery stenosis as a means to risk stratify patients. However, with improvements in vascular imaging techniques such as CT angiography and MR angiography, ultrasonography, and PET/CT, it is now possible to risk stratify patients, not just on the degree of carotid artery stenosis but also on how vulnerable the plaque is to rupture, resulting in ischemic stroke...
January 2016: Journal of Neurosurgery
https://www.readbyqxmd.com/read/26211685/spatio-temporal-quantification-of-carotid-plaque-neovascularization-on-contrast-enhanced-ultrasound-correlation-with-visual-grading-and-histopathology
#13
COMPARATIVE STUDY
Q Zhang, C Li, H Han, W Dai, J Shi, Y Wang, W Wang
OBJECTIVE/BACKGROUND: To evaluate whether carotid intraplaque neovascularization (IPN) can be accurately assessed by two types of quantitative analysis on contrast enhanced ultrasound (CEUS), the time intensity curve analysis and the analysis of contrast agent spatial distributions, and whether the quantitative analysis correlates with semiquantitative visual interpretation and histopathology. METHODS: Forty-four plaques in 34 patients were included for CEUS examination...
September 2015: European Journal of Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/26180793/use-of-contrast-enhanced-ultrasound-in-carotid-atherosclerotic-disease-limits-and-perspectives
#14
REVIEW
Gianfranco Varetto, Lorenzo Gibello, Claudio Castagno, Simone Quaglino, Matteo Ripepi, Emilio Benintende, Andrea Gattuso, Paolo Garneri, Stefano Zan, Giacomo Capaldi, Ugo Bertoldo, Pietro Rispoli
Contrast-enhanced ultrasound (CEUS) has recently become one of the most versatile and powerful diagnostic tools in vascular surgery. One of the most interesting fields of application of this technique is the study of the carotid atherosclerotic plaque vascularization and its correlation with neurological symptoms (transient ischemic attack, minor stroke, and major stroke) and with the characteristics of the "vulnerable plaque" (surface ulceration, hypoechoic plaques, intraplaque hemorrhage, thinner fibrous cap, and carotid plaque neovascularization at histopathological analysis of the sample after surgical removal)...
2015: BioMed Research International
https://www.readbyqxmd.com/read/26098322/positive-correlation-between-neovascularization-degree-of-carotid-atherosclerosis-determined-by-contrast-enhanced-ultrasound-and-level-of-serum-c-reactive-protein
#15
Xiaoni Chang, Jun Feng, Litao Ruan, Jing Shang, Yanqiu Yang, Jian Sun, Ying Dang, Yan Song
BACKGROUND: Neovascularization is one of the most important risk factors for unstable plaque. This study was designed to correlate plaque thickness, artery stenosis and levels of serum C-reactive protein with the degree of intraplaque enhancement determined by contrast-enhanced ultrasound. PATIENTS AND METHODS: Contrast-enhanced ultrasound was performed on 72 carotid atherosclerotic plaques in 48 patients. Contrast enhancement within the plaque was categorized as grade 1, 2 or 3...
May 2015: VASA. Zeitschrift Für Gefässkrankheiten
https://www.readbyqxmd.com/read/26090834/communication-of-inwardly-projecting-neovessels-with-the-lumen-contributes-to-symptomatic-intraplaque-hemorrhage-in-carotid-artery-stenosis
#16
Nobutaka Horie, Yoichi Morofuji, Minoru Morikawa, Yohei Tateishi, Tsuyoshi Izumo, Kentaro Hayashi, Akira Tsujino, Izumi Nagata
OBJECT: Recent studies have demonstrated that plaque morphology can contribute to identification of patients at high risk of carotid artery atherosclerosis as well as the degree of stenosis in those with carotid atherosclerosis. Neovascularization of carotid plaques is associated with plaque vulnerability. However, the mechanism of neovascularization in intraplaque hemorrhage (IPH) and its clinical contribution remain undetermined. In this study, the authors aimed to clarify the characteristics of neovessel appearance with a focus on inwardly projecting neovessels, which are reportedly important in plaque advancement...
November 2015: Journal of Neurosurgery
https://www.readbyqxmd.com/read/26074459/quantification-of-carotid-plaque-elasticity-and-intraplaque-neovascularization-using-contrast-enhanced-ultrasound-and-image-registration-based-elastography
#17
Qi Zhang, Chaolun Li, Moli Zhou, Yu Liao, Chunchun Huang, Jun Shi, Yuanyuan Wang, Wenping Wang
It is valuable for evaluation of carotid plaque vulnerability to investigate the relation between intraplaque neovascularization (IPN) and plaque elasticity. The contrast-enhanced ultrasound (CEUS) has been used in IPN measurement, but it cannot assess plaque elasticity. The aim of this study was to develop an ultrasound elastography technique based on registration of CEUS sequential images and to use this technique for direct comparison between IPN and plaque elasticity. We employed a nonrigid image registration method using the free-form deformation model to register a pair of clinical CEUS images at systole and diastole...
September 2015: Ultrasonics
https://www.readbyqxmd.com/read/25883974/diffuse-calcifications-protect-carotid-plaques-regardless-of-the-amount-of-neoangiogenesis-and-related-histological-complications
#18
Francesco Vasuri, Silvia Fittipaldi, Rodolfo Pini, Alessio Degiovanni, Raffaella Mauro, Antonia D'Errico-Grigioni, Gianluca Faggioli, Andrea Stella, Gianandrea Pasquinelli
BACKGROUND: Neoangiogenesis is crucial in plaque progression and instability. Previous data from our group showed that Nestin-positive intraplaque neovessels correlated with histological complications. The aim of the present work is to evaluate the relationship between neoangiogenesis, plaque morphology, and clinical instability of the plaque. MATERIALS AND METHODS: Seventy-three patients (53 males and 20 females, mean age 71 years) were consecutively enrolled. Clinical data and 14 histological variables, including intraplaque hemorrhage and calcifications, were collected...
2015: BioMed Research International
https://www.readbyqxmd.com/read/25868732/contrast-enhanced-ultrasonography-of-the-carotids
#19
Vasileios Rafailidis, Georgios Pitoulias, Konstantinos Kouskouras, Dimitrios Rafailidis
Contrast-enhanced ultrasonography of the carotids has recently emerged as a complementary examination to conventional carotid Doppler ultrasonography. It is an examination providing improved visualization of the vascular lumen, more accurate and detailed delineation of the vascular wall, and identification of atherosclerotic plaques. Moreover, contrast-enhanced ultrasonography has specific advantages over conventional ultrasonography and plays an important role in the diagnosis of the vulnerable carotid plaque, as it can identify intraplaque neovascularization and carotid plaque ulceration...
October 2015: Ultrasonography
https://www.readbyqxmd.com/read/25843115/expression-of-vasohibin-1-in-human-carotid-atherosclerotic-plaque
#20
Ryu Fukumitsu, Manabu Minami, Kazumichi Yoshida, Manabu Nagata, Mika Yasui, Sei Higuchi, Risako Fujikawa, Taichi Ikedo, Sen Yamagata, Yasufumi Sato, Hidenori Arai, Masayuki Yokode, Susumu Miyamoto
AIM: In patients with carotid plaque, intraplaque hemorrhage arising from ruptured neovascular vessels within the neointima is an important cause of stroke. The expression of Vasohibin-1 (VASH1), a negative feedback regulator of angiogenesis, occurs in the microvessel endothelial cells of various solid tumors and the arterial wall. However, the roles of VASH1 in the pathogenesis of atherosclerotic diseases remain unclear. The present study aimed to clarify the relevance of the VASH1 expression and plaque instability in human carotid plaques...
2015: Journal of Atherosclerosis and Thrombosis
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