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Anxiety Disordes

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https://www.readbyqxmd.com/read/29786922/finding-factors-that-predict-treatment-resistant-depression-results-of-a-cohort-study
#1
M Soledad Cepeda, Jenna Reps, Patrick Ryan
BACKGROUND: Treatment for depressive disorders often requires subsequent interventions. Patients who do not respond to antidepressants have treatment-resistant depression (TRD). Predicting who will develop TRD may help healthcare providers make more effective treatment decisions. We sought to identify factors that predict TRD in a real-world setting using claims databases. METHODS: A retrospective cohort study was conducted in a US claims database of adult subjects with newly diagnosed and treated depression with no mania, dementia, and psychosis...
May 22, 2018: Depression and Anxiety
https://www.readbyqxmd.com/read/29786898/adults-with-comorbid-posttraumatic-stress-disorder-alcohol-use-disorder-and-opioid-use-disorder-the-effectiveness-of-modified-prolonged-exposure
#2
Kelly R Peck, Julie A Schumacher, Paul R Stasiewicz, Scott F Coffey
Opioid use disorders (OUDs) are a growing problem in the United States. When OUDs co-occur with problematic drinking and posttraumatic stress disorder (PTSD), negative drug-related mental and physical health outcomes may be exacerbated. Thus, it is important to establish whether PTSD treatments with established efficacy for dually diagnosed individuals also demonstrate efficacy in individuals who engage in problematic drinking and concurrent opioid misuse. Adults who met DSM-IV-TR criteria for PTSD and alcohol dependence were recruited from a substance use treatment facility and were randomly assigned to receive either modified prolonged exposure (mPE) therapy for PTSD or a non-trauma-focused comparison treatment...
May 22, 2018: Journal of Traumatic Stress
https://www.readbyqxmd.com/read/29786810/-epilepsy-and-comorbid-neurodevelopmental-disorders
#3
Viviann Nordin, Ingrid B Olsson, Torbjörn Tomson
In children and adults with epilepsy, it is important to be aware of and diagnose common comorbidities that may have a large impact on quality of life. Comorbid neurodevelopmental disorders include intellectual disability, autism, and attention deficit hyperactivity disorder (ADHD). Depression and anxiety are common findings, and also the risk of psychosis is increased. The medication used to treat these comorbidities is found to be effective with little risks of seizure exacerbation, i.e. medication with methylphenidate, selective serotonin reuptake inhibitors (SSRIs) and second generation neuroleptics...
May 22, 2018: Läkartidningen
https://www.readbyqxmd.com/read/29786495/occupational-moral-injury-and-mental-health-systematic-review-and-meta-analysis
#4
Victoria Williamson, Sharon A M Stevelink, Neil Greenberg
BACKGROUND: Many people confront potentially morally injurious experiences (PMIEs) in the course of their work which can violate deeply held moral values or beliefs, putting them at risk for psychological difficulties (e.g. post-traumatic stress disorder (PTSD), depression, etc.).AimsWe aimed to assess the effect of moral injury on mental health outcomes. METHOD: We conducted a systematic review and meta-analysis to assess the association between work-related PMIEs and mental health disorders...
June 2018: British Journal of Psychiatry: the Journal of Mental Science
https://www.readbyqxmd.com/read/29786066/repeated-social-defeat-induced-neuroinflammation-anxiety-like-behavior-and-resistance-to-fear-extinction-were-attenuated-by-the-cannabinoid-receptor-agonist-win55-212-2
#5
Sabrina Francesca Lisboa, Anzela Niraula, Leonardo Barbosa Resstel, Francisco Silveira Guimaraes, Jonathan P Godbout, John F Sheridan
Psychosocial stress contributes to the development of psychiatric disorders. Repeated social defeat (RSD) is a murine stressor that causes a release of inflammatory monocytes into circulation. Moreover, RSD-induced anxiety-like behavior is dependent on the recruitment of these monocytes to the brain. Activation of the endocannabinoid (ECB) system may modulate both neuroendocrine and inflammatory responses mediated by stress. Therefore, we hypothesized that a cannabinoid receptor agonist would attenuate RSD-induced inflammation, anxiety, and stress sensitization...
April 17, 2018: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29785522/non-invasive-vagus-nerve-stimulation-significantly-improves-quality-of-life-in-patients-with-persistent-postural-perceptual-dizziness
#6
Ozan E Eren, Filipp Filippopulos, Kristina Sönmez, Ken Möhwald, Andreas Straube, Florian Schöberl
Persistent postural-perceptual dizziness (PPPD) is one of the most common causes of chronic vestibular disorders, with a substantial portion of the affected patients showing no significant improvement to standard therapies (i.e., pharmacotherapy, behavioral psychotherapy). Patients with PPPD have been shown to have a significant comorbidity with anxiety disorders and depression. Further, these patients show an activation of the autonomic nervous system resulting in symptoms such as nausea, increase of heart rate, and sweating...
May 21, 2018: Journal of Neurology
https://www.readbyqxmd.com/read/29785336/targeting-the-microbiota-from-irritable-bowel-syndrome-to-mood-disorders-focus-on-probiotics-and-prebiotics
#7
M M Pusceddu, K Murray, M G Gareau
Purpose of review: The crosstalk between the gut and the brain has revealed a complex communication system responsible for maintaining a proper gastrointestinal homeostasis as well as affect emotional mood and cognitive functions. Recent research has revealed that beneficial manipulation of the microbiota by probiotics and prebiotics represent an emerging and novel strategy for the treatment of a large spectrum of diseases ranging from visceral pain to mood disorders. The review critically evaluates current knowledge of the effects exerted by both probiotics and prebiotics in irritable bowel syndrome (IBS) and mood disorders such as anxiety and depression...
March 2018: Current Pathobiology Reports
https://www.readbyqxmd.com/read/29785161/prevalence-and-psychological-stress-in-recurrent-aphthous-stomatitis-among-female-dental-students-in-saudi-arabia
#8
Muhammed Ajmal, Lujain Ibrahim, Nada Mohammed, Heba Al-Qarni
Introduction: Recurrent Aphthous Stomatitis (RAS) is a common oral mucosal disorder which is characterized by recurrent ulcerations mainly confined to non-keratinized oral mucosa. Though the exact etiology is imprecise, stress and anxiety were found to be linked with the onset of RAS. The present study was directed to know the prevalence of RAS among female dental students in King Khalid University, to find out the association between RAS and psychological stress and the effectiveness of Hospital Anxiety and Depression scale (HADS) in finding out the psychological profile of RAS patients...
2018: Clujul Medical (1957)
https://www.readbyqxmd.com/read/29785110/prefrontoparietal-dysfunction-during-emotion-regulation-in-anxiety-disorder-a-meta-analysis-of-functional-magnetic-resonance-imaging-studies
#9
Hai-Yang Wang, Xiao-Xia Zhang, Cui-Ping Si, Yang Xu, Qian Liu, He-Tao Bian, Bing-Wei Zhang, Xue-Lin Li, Zhong-Rui Yan
Objective: Impairments in emotion regulation, and more specifically in cognitive reappraisal, are thought to play a key role in the pathogenesis of anxiety disorders. However, the available evidence on such deficits is inconsistent. To further illustrate the neurobiological underpinnings of anxiety disorder, the present meta-analysis summarizes functional magnetic resonance imaging (fMRI) findings for cognitive reappraisal tasks and investigates related brain areas. Methods: We performed a comprehensive series of meta-analyses of cognitive reappraisal fMRI studies contrasting patients with anxiety disorder with healthy control (HC) subjects, employing an anisotropic effect-size signed differential mapping approach...
2018: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/29784925/acrylamide-acute-neurotoxicity-in-adult-zebrafish
#10
Melissa Faria, Tamar Ziv, Cristian Gómez-Canela, Shani Ben-Lulu, Eva Prats, Karen Adriana Novoa-Luna, Arie Admon, Benjamin Piña, Romà Tauler, Leobardo Manuel Gómez-Oliván, Demetrio Raldúa
Acute exposure to acrylamide (ACR), a type-2 alkene, may lead to a ataxia, skeletal muscles weakness and numbness of the extremities in human and laboratory animals. In the present manuscript, ACR acute neurotoxicity has been characterized in adult zebrafish, a vertebrate model increasingly used in human neuropharmacology and toxicology research. At behavioral level, ACR-treated animals exhibited "depression-like" phenotype comorbid with anxiety behavior. At transcriptional level, ACR induced down-regulation of regeneration-associated genes and up-regulation of oligodendrocytes and reactive astrocytes markers, altering also the expression of genes involved in the presynaptic vesicle cycling...
May 21, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29784115/estimated-prevalence-of-psychiatric-comorbidities-in-u-s-adolescents-with-depression-by-race-ethnicity-2011-2012
#11
Bridget E Weller, Kathryn L Blanford, Ashley M Butler
PURPOSE: Comorbid psychiatric conditions in adolescents with depression are a public health concern. However, little is known about the prevalence of comorbidities in separate racial/ethnic groups. This study estimated the national prevalence of comorbidities for black, Hispanic, and white adolescents separately, and compared the prevalence of comorbidities between adolescents with and without depression. METHODS: This secondary analysis used data from the 2011-2012 National Survey of Children's Health, a nationally representative, cross-sectional survey of U...
June 2018: Journal of Adolescent Health: Official Publication of the Society for Adolescent Medicine
https://www.readbyqxmd.com/read/29783216/-complex-of-psycho-hygienic-correction-measures-of-personality-features-of-hiv-infected-men-and-evaluation-of-their-efficiency
#12
Ihor V Serheta, Oksana B Dudarenko, Olha P Mostova, Tetiana V Lobastova, Vitalii M Andriichuk, Larysa M Vakolyuk, Olha M Yakubovska
OBJECTIVE: Introduction: In addition to adequate diagnosis and treatment of HIV-infected individuals, development, scientific substantiation and implementation of psycho-hygienic measures aimed at correcting the processes of forming personality traits and improving the psycho-emotional state of HIV-infected individuals are of particular importance. The aim: The purpose of the scientific research was to determine the most significant changes of situational and personal anxiety indicators, the degree of gravity of the asthenic state and depressive manifestations that were recorded in the context of the introduction of a number of measures for psycho-hygienic correction...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29783186/-1-h-nmr-and-uplc-ms-metabolomics-functional-tools-for-exploring-chemotypic-variation-in-sceletium-tortuosum-from-two-provinces-in-south-africa
#13
Jianping Zhao, Ikhlas A Khan, Sandra Combrinck, Maxleene Sandasi, Weiyang Chen, Alvaro M Viljoen
Sceletium tortuosum (Aizoaceae) is widely recognised for the treatment of stress, anxiety and depression, as well as for obsessive compulsive disorders. A comprehensive intraspecies chemotypic variation study, using samples harvested from two distinct regions of South Africa, was done using both proton nuclear magnetic resonance (1 H-NMR) spectroscopy of methanol extracts (N = 145) and ultra performance liquid chromatography-mass spectrometry (UPLC-MS) of acid/base extracts (N = 289). Chemometric analysis of the 1 H-NMR data indicated two main clusters that were region-specific (Northern Cape and Western Cape provinces)...
May 17, 2018: Phytochemistry
https://www.readbyqxmd.com/read/29783160/children-s-sleep-problems-are-associated-with-poorer-student-teacher-relationship-quality
#14
Alex S Holdaway, Stephen P Becker
OBJECTIVE: Children's sleep problems are associated with poorer student functioning in the school environment, including impairment in peer relationships; yet, no studies have examined sleep functioning in relation to the student-teacher relationship. The objective of this study was to examine whether child-rated total sleep problems or specific sleep problem domains (bedtime problems, nighttime problems, or daytime sleepiness) were associated with teacher-rated student-teacher closeness and conflict after controlling for student mental health symptoms known to be associated with both greater sleep problems and poorer student-teacher relationship quality...
December 20, 2017: Sleep Medicine
https://www.readbyqxmd.com/read/29782423/the-development-of-the-working-alliance-and-its-ability-to-predict-outcome-in-emotion-focused-therapy-for-social-anxiety-disorder
#15
Gilad Adler, Ben Shahar, Tohar Dolev, Sigal Zilcha-Mano
The study focuses on the alliance of 12 patients receiving emotion-focused therapy for social anxiety. Anxiety symptoms and patient perception of the working alliance were examined weekly. The first eight sessions of each patient were coded for within- and between-sessions alliance levels (1008 segments were coded). At the sample level, the alliance shows linear development over time but high variability between individuals. More than half the patients showed alliance development consistent with the rupture-resolution pattern...
May 17, 2018: Journal of Nervous and Mental Disease
https://www.readbyqxmd.com/read/29782305/tatami-mats-a-source-of-pitted-keratolysis-in-a-martial-arts-athlete
#16
Anamaria Balić, Zrinka Bukvić Mokos, Branka Marinović, Daniela Ledić Drvar
Dear Editor, Pitted keratolysis (PK), also known as keratosis plantaris sulcatum, is a non-inflammatory, bacterial, superficial cutaneous infection, characterized by many discrete superficial crateriform ''pits'' and erosions in the thickly keratinized skin of the weight-bearing regions of the soles of the feet (1). The disease often goes unnoticed by the patient, but when it is noticed it is because of the unbearable malodor and hyperhidrosis of the feet, which are socially unacceptable and cause great anxiety to many of the patients...
April 2018: Acta Dermatovenerologica Croatica: ADC
https://www.readbyqxmd.com/read/29781963/comorbidities-and-mobility-in-lower-limb-prosthesis-users
#17
Shane R Wurdeman, Phillip M Stevens, James H Campbell
OBJECTIVE: To determine the impact of comorbidities on mobility in patients with lower limb prostheses. DESIGN: Cohort database chart review examining mobility in lower limb prosthesis users grouped according to comorbidities. Regression models were used to determine significant predictor comorbidities for mobility. General linear univariate models were implemented to investigate differences in mobility among cohorts (n=596). RESULTS: Patient age and history of stroke, peripheral vascular disease, and anxiety/panic disorders were predictors of decreased mobility...
May 17, 2018: American Journal of Physical Medicine & Rehabilitation
https://www.readbyqxmd.com/read/29781886/axis-ii-personality-disorders-are-linked-to-an-adverse-course-of-bipolar-disorder
#18
Robert M Post, Susan McElroy, Ralph Kupka, Trisha Suppes, Gerhard Hellemann, Willem Nolen, Mark Frye, Paul Keck, Heinz Grunze, Michael Rowe
The relationship of personality disorder (PD) psychopathology to the course of bipolar disorder remains inadequately described. After giving informed consent, more than 782 outpatients with bipolar disorder rated themselves on the 99-item Personality Disorder Questionnaire, Version 4 (PDQ4) when depressed or euthymic. They also rated six poor prognosis factors (PPFs). The relationships of the PPFs to the total PDQ4 score were examined by a linear regression. Even after correcting for the higher PDQ4 scores observed when patients were suffering depression, the PDQ4 was significantly related to a history of child abuse, early age of onset, an anxiety disorder comorbidity, rapid cycling, and 20 or more previous episodes, but not substance abuse...
May 17, 2018: Journal of Nervous and Mental Disease
https://www.readbyqxmd.com/read/29781649/treatment-of-social-approach-processes-in-adults-with-social-anxiety-disorder
#19
Lynn E Alden, Kristin Buhr, Melisa Robichaud, Jennifer L Trew, M Leili Plasencia
OBJECTIVE: Despite the social impairment associated with social anxiety disorder (SAD), little research has examined the impact of treatment on positive relational functioning. Accordingly, the authors conducted a treatment outcome study to evaluate a cognitive behavior therapy (CBT) regimen augmented by a relational focus (CBT-R) relative to a graduated exposure-applied relaxation (GEAR) regimen and wait list (WL) control. To examine the mechanism(s) that underlies treatment effects, they used structural equation modeling (SEM) to evaluate two potential mediators, change in judgment biases and in safety behaviors...
June 2018: Journal of Consulting and Clinical Psychology
https://www.readbyqxmd.com/read/29781648/a-mobile-app-for-social-anxiety-disorder-a-three-arm-randomized-controlled-trial-comparing-mobile-and-pc-based-guided-self-help-interventions
#20
Timo Stolz, Ava Schulz, Tobias Krieger, Alessia Vincent, Antoine Urech, Christian Moser, Stefan Westermann, Thomas Berger
OBJECTIVE: Internet-based cognitive-behavioral treatments (ICBT) have shown promise for various mental disorders, including social anxiety disorder (SAD). Most of these treatments have been delivered on desktop computers. However, the use of smartphones is becoming ubiquitous and could extend the reach of ICBT into users' everyday life. Only a few studies have empirically examined the efficacy of ICBT delivered through a smartphone app and there is no published study on mobile app delivered ICBT for SAD...
June 2018: Journal of Consulting and Clinical Psychology
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