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Anxiety Disordes

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https://www.readbyqxmd.com/read/28231027/insomnia-sleep-quality-and-quality-of-life-in-mild-to-moderate-parkinson-s-disease
#1
Shirin Shafazand, Douglas M Wallace, Kristopher L Arheart, Silvia Vargas, Corneliu C Luca, Henry Moore, Heather Katzen, Bonnie Levin, Carlos Singer
RATIONALE: Sleep disorders are prevalent in Parkinson's disease and yet under reported in clinical settings. The contribution of sleep disorders to health-related quality of life (HRQOL) for patients with this degenerative neurological disease are not well known. OBJECTIVES: To evaluate the impact of insomnia symptoms, obstructive sleep apnea (OSA), and poor sleep quality on HRQOL in a cohort of patients with idiopathic Parkinson's disease. METHODS: We enrolled a convenience sample of 66 adults seen in the University of Miami Movement Disorders Clinic between July 2011 and June 2013...
February 23, 2017: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/28230289/mice-lacking-bcas1-a-novel-myelin-associated-protein-display-hypomyelination-schizophrenia-like-abnormal-behaviors-and-upregulation-of-inflammatory-genes-in-the-brain
#2
Tetsuya Ishimoto, Kensuke Ninomiya, Ran Inoue, Masato Koike, Yasuo Uchiyama, Hisashi Mori
The abnormal expression and function of myelin-related proteins contribute to nervous system dysfunction associated with neuropsychiatric disorders; however, the underlying mechanism of this remains unclear. We found here that breast carcinoma amplified sequence 1 (BCAS1), a basic protein abundant in the brain, was expressed specifically in oligodendrocytes and Schwann cells, and that its expression level was decreased by demyelination. This suggests that BCAS1 is a novel myelin-associated protein. BCAS1 knockout mice displayed schizophrenia-like behavioral abnormalities and a tendency toward reduced anxiety-like behaviors...
February 23, 2017: Glia
https://www.readbyqxmd.com/read/28229807/using-psychoeducation-and-role-induction-to-improve-completion-rates-in-cognitive-behavioural-therapy
#3
Jaime Delgadillo, Martin Groom
BACKGROUND: Pre-treatment role induction interventions have been suggested to potentially enhance attendance and clinical outcomes in psychotherapy. AIMS: This study aimed to evaluate the effects of a programme of three transdiagnostic seminars (TDS) for patients with common mental disorders accessing cognitive behavioural therapy (CBT) in primary care. TDS included CBT psychoeducation and role induction. METHOD: A random sample of patients (n = 49) participated in TDS followed by CBT (TDS+CBT) and they were compared with matched controls (n = 49) accessing usual CBT...
March 2017: Behavioural and Cognitive Psychotherapy
https://www.readbyqxmd.com/read/28229356/symptoms-of-swallowing-anxiety-in-panic-disorder-patients-and-associated-psychopathologic-factors
#4
Ersin Budak, İbrahim Taymur, Sinay Önen, Bilgen Biçer Kanat, Önder Akdeniz, Hakan Demirci
AIM: The aim of this study was to investigate symptoms of swallowing difficulty in Panic Disorder (PD) patients and the factors associated with these symptoms. METHODS: In the pre-phase of the study, 22 PD patients who were treated in psychiatry outpatient clinics and who were found to have swallowing difficulty were evaluated. PD patients were asked to write about their thoughts, feelings and behaviors associated with swallowing difficulty. Later, these texts were examined and 41 expressions were identified in which patients described their swallowing difficulty...
February 22, 2017: Eating and Weight Disorders: EWD
https://www.readbyqxmd.com/read/28229112/chronic-psychosocial-stressors-in-adulthood-studies-in-mice-rats-and-tree-shrews
#5
REVIEW
Christopher R Pryce, Eberhard Fuchs
Human psychological stress is the major environmental risk factor for major depression and certain of the anxiety disorders. Psychological stressors often occur in the context of the adult social environment, and they or the memory formed of them impact on the individual across an extended period, thereby constituting chronic psychosocial stress (CPS). Psychosocial stressors often involve loss to the individual, such as the ending of a social relationship or the onset of interpersonal conflict leading to loss of social control and predictability...
February 2017: Neurobiology of Stress
https://www.readbyqxmd.com/read/28229105/early-life-adversity-lasting-consequences-for-emotional-learning
#6
REVIEW
Harm J Krugers, J Marit Arp, Hui Xiong, Sofia Kanatsou, Sylvie L Lesuis, Aniko Korosi, Marian Joels, Paul J Lucassen
The early postnatal period is a highly sensitive time period for the developing brain, both in humans and rodents. During this time window, exposure to adverse experiences can lastingly impact cognitive and emotional development. In this review, we briefly discuss human and rodent studies investigating how exposure to adverse early life conditions - mainly related to quality of parental care - affects brain activity, brain structure, cognition and emotional responses later in life. We discuss the evidence that early life adversity hampers later hippocampal and prefrontal cortex functions, while increasing amygdala activity, and the sensitivity to stressors and emotional behavior later in life...
February 2017: Neurobiology of Stress
https://www.readbyqxmd.com/read/28229024/modafinil-decreases-anxiety-like-behaviour-in-zebrafish
#7
Adrian Johnson, Trevor James Hamilton
Modafinil (2-((diphenylmethyl)sulfinyl)acetamide), a selective dopamine and norepinephrine transporter inhibitor, is most commonly prescribed for narcolepsy but has gained recent interest for treating a variety of disorders. Zebrafish (Danio rerio) are becoming a model of choice for pharmacological and behavioural research. To investigate the behavioural effects of modafinil on anxiety, we administered doses of 0, 2, 20, and 200 mg/L for 30 minutes then tested zebrafish in the novel approach test. In this test, the fish was placed into a circular arena with a novel object in the center and motion-tracking software was used to quantify the time the fish spent in the outer area of the arena (thigmotaxis zone), middle third of the arena (transition zone) and center of the arena, as well as total distance traveled, immobility and meandering...
2017: PeerJ
https://www.readbyqxmd.com/read/28228566/reduced-cognitive-function-in-patients-with-parkinson-disease-and-obstructive-sleep-apnea
#8
Victoria P Mery, Priti Gros, Anne-Louise Lafontaine, Ann Robinson, Andrea Benedetti, R John Kimoff, Marta Kaminska
OBJECTIVE: To assess the association between obstructive sleep apnea (OSA) and nonmotor symptoms (NMS), including cognitive dysfunction, in patients with Parkinson disease (PD). METHODS: Patients with idiopathic PD, recruited from a movement disorder clinic, underwent overnight polysomnography. OSA was defined as an apnea-hypopnea index (AHI) ≥15/h. PD severity was assessed using the Hoehn & Yahr (H&Y) scale and the Movement Disorder Society Unified Parkinson's Disease Rating Scale (MDS-UPDRS)...
February 22, 2017: Neurology
https://www.readbyqxmd.com/read/28228177/psychiatric-diagnoses-in-older-people-with-intellectual-disability-in-comparison-with-the-general-population-a-register-study
#9
A Axmon, P Björne, L Nylander, G Ahlström
AIMS: To describe the occurrence of psychiatric diagnoses in a specialist care setting in older people with intellectual disability (ID) in relation to those found in the same age group in the general population. METHOD: A cohort of people with ID (n = 7936), aged 55 years or more in 2012, was identified, as was an age and sex-matched cohort from the general population (n = 7936). Information regarding psychiatric diagnoses during 2002-2012 was collected from the National Patient Register, which contains records from all inpatient care episodes and outpatient specialist visits in Sweden...
February 23, 2017: Epidemiology and Psychiatric Sciences
https://www.readbyqxmd.com/read/28228081/the-neurobiology-and-psychiatric-perspective-of-vaginismus-linking-the-pharmacological-and-psycho-social-interventions
#10
Zuri Shahidii Kadir, Hatta Sidi, Jaya Kumar, Srijit Das, Marhani Midin, Najwa Baharuddin
Vaginismus is an involuntary muscle contraction of the outer third of vaginal barrel causing sexual penetration almost impossible. It is generally classified under sexual pain disorder (SPD). In Diagnostic and Statistical Manual, 5th edition, it is classified under the new rubric of Genito-Pelvic Pain/Sexual Penetration Disorder. This fear-avoidance condition poses an ongoing significant challenge to the medical and health professionals due to the very demanding needs in health care despite its unpredictable prognosis...
February 22, 2017: Current Drug Targets
https://www.readbyqxmd.com/read/28226306/task-dependent-modulation-of-amygdala-connectivity-in-social-anxiety-disorder
#11
Lora Minkova, Ronald Sladky, Georg S Kranz, Michael Woletz, Nicole Geissberger, Christoph Kraus, Rupert Lanzenberger, Christian Windischberger
Increased amygdala activation is consistently found in patients suffering from social anxiety disorder (SAD), a psychiatric condition characterized by an intense fear of social situations and scrutiny. Disruptions in the amygdalar-frontal network in SAD may explain the inability of frontal regions to appropriately down-regulate amygdalar hyper-activation. In this study, we measured 15 SAD patients and 15 healthy controls during an affective counting Stroop task with emotional faces to assess the interaction of affective stimuli with a cognitive task in SAD, as well as to investigate the causal interactions between the amygdala and the medial orbitofrontal cortex (OFC) using dynamic causal modeling (DCM)...
February 9, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28225710/chronic-stress-exacerbates-neuropathic-pain-via-the-integration-of-stress-affect-related-information-with-nociceptive-information-in-the-central-nucleus-of-the-amygdala
#12
Ming-Jia Li, Ling-Yu Liu, Lin Chen, Jie Cai, You Wan, Guo-Gang Xing
Exacerbation of pain by chronic stress and co-morbidity of pain with stress-related psychiatric disorders including anxiety and depression, represent significant clinical challenges. However, the underlying mechanisms still remain unclear. Here, we investigated whether chronic forced swim (FS) stress-induced exacerbation of neuropathic pain is mediated by the integration of stress-affect related information with nociceptive information in the central nucleus of the amygdala (CeA). We first demonstrated that chronic FS stress (CFSS) indeed produces both depressive-like behaviors and exacerbation of spared nerve injury (SNI)-induced mechanical allodynia in rats...
December 29, 2016: Pain
https://www.readbyqxmd.com/read/28225509/psychometric-properties-of-the-reconstructed-hamilton-depression-and-anxiety-scales
#13
Eliora Porter, Dianne L Chambless, Kevin S McCarthy, Robert J DeRubeis, Brian A Sharpless, Marna S Barrett, Barbara Milrod, Steven D Hollon, Jacques P Barber
Although widely used, the Hamilton Rating Scale for Depression (HRSD) and Hamilton Anxiety Rating Scale (HARS) discriminate poorly between depression and anxiety. To address this problem, Riskind, Beck, Brown, and Steer (J Nerv Ment Dis. 175:474-479, 1987) created the Reconstructed Hamilton Scales by reconfiguring HRSD and HARS items into modified scales. To further analyze the reconstructed scales, we examined their factor structure and criterion-related validity in a sample of patients with major depressive disorder and no comorbid anxiety disorders (n = 215) or with panic disorder and no comorbid mood disorders (n = 149)...
February 20, 2017: Journal of Nervous and Mental Disease
https://www.readbyqxmd.com/read/28225508/suicidal-ideation-vs-suicide-attempts-clinical-and-psychosocial-profile-differences-among-depressed-patients-a-study-on-personality-traits-psychopathological-variables-and-sociodemographic-factors-in-228-patients
#14
Ute Lewitzka, Sina Spirling, Dirk Ritter, Michael Smolka, Sarah Goodday, Michael Bauer, Werner Felber, Tom Bschor
This study investigated whether personality traits, psychopathological characteristics, and sociodemographic factors in depressed patients differentiate patients with only suicidal thoughts from those who have attempted suicide. We investigated two groups of patients with an affective disorder: 198 patients with a suicide attempt within the last 3 months (sex ratio male to female, 1:1.3; mean age male to female, 44.8/44.7 years) and 30 patients without a suicide attempt but with suicidal thoughts (sex ratio male to female, 1:2; mean age male to female, 39...
February 20, 2017: Journal of Nervous and Mental Disease
https://www.readbyqxmd.com/read/28225502/associations-between-prospective-symptom-changes-and-slow-wave-activity-in-patients-with-internet-gaming-disorder-a-resting-state-eeg-study
#15
Yeon Jin Kim, Jun-Young Lee, Sohee Oh, Minkyung Park, Hee Yeon Jung, Bo Kyung Sohn, Sam-Wook Choi, Dai Jin Kim, Jung-Seok Choi
The identification of the predictive factors and biological markers associated with treatment-related changes in the symptoms of Internet gaming disorder (IGD) may provide a better understanding of the pathophysiology underlying this condition. Thus, the present study aimed to identify neurophysiological markers associated with symptom changes in IGD patients and to identify factors that may predict symptom improvements following outpatient treatment with pharmacotherapy. The present study included 20 IGD patients (mean age: 22...
February 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28225191/a-review-of-untangling-the-association-between-migraine-pain-and-anxiety-examining-migraine-and-generalized-anxiety-disorders-in-a-canadian-population-based-study
#16
https://www.readbyqxmd.com/read/28224735/genetic-risk-variants-for-social-anxiety
#17
Murray B Stein, Chia-Yen Chen, Sonia Jain, Kevin P Jensen, Feng He, Steven G Heeringa, Ronald C Kessler, Adam Maihofer, Matthew K Nock, Stephan Ripke, Xiaoying Sun, Michael L Thomas, Robert J Ursano, Jordan W Smoller, Joel Gelernter
Social anxiety is a neurobehavioral trait characterized by fear and reticence in social situations. Twin studies have shown that social anxiety has a heritable basis, shared with neuroticism and extraversion, but genetic studies have yet to demonstrate robust risk variants. We conducted genomewide association analysis (GWAS) of subjects within the Army Study To Assess Risk and Resilience in Servicemembers (Army STARRS) to (i) determine SNP-based heritability of social anxiety; (ii) discern genetic risk loci for social anxiety; and (iii) determine shared genetic risk with neuroticism and extraversion...
March 2017: American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics
https://www.readbyqxmd.com/read/28224734/anxiety-genetics-dispatches-from-the-frontier
#18
Jordan W Smoller
Anxiety disorders are the most common class of psychiatric disorders and incur an enormous burden in terms of economic costs, disability and personal suffering. Despite their public health importance and documented heritability, genetic research aimed at identifying the genetic contributions to these disorders has had limited success, particularly in comparison to recent advances in the genetics of other major psychiatric disorders. The major factor contributing to this lagging progress has been a dearth of well-powered genomic studies...
March 2017: American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics
https://www.readbyqxmd.com/read/28224378/depression-and-anxiety-behaviour-in-a-rat-model-of-chronic-migraine
#19
Mingjie Zhang, Yufei Liu, Mangsuo Zhao, Wenjing Tang, Xiaolin Wang, Zhao Dong, Shengyuan Yu
BACKGROUND: Epidemiological and clinical studies have demonstrated comorbidity between migraine and affective disorders. However, it is unclear whether chronic migraine can lead to affective disorders in other animals. METHODS: A classical chronic migraine rat model (repeated dura mater inflammatory soup [IS] infusion) was used to evaluate depression and anxiety behaviour via weight, sucrose preference test, open field test and elevated plus maze test. RESULTS: We found that sucrose preference, locomotor and rearing behaviours, inner zoon distance percent, open-arm entries percent and serotonin and dopamine levels in the prefrontal cortex decreased significantly in the IS group compared with those in the control group; co-administration of low-dose amitriptyline ameliorated these deficits...
December 2017: Journal of Headache and Pain
https://www.readbyqxmd.com/read/28224080/brain-activation-to-task-irrelevant-disorder-related-threat-in-social-anxiety-disorder-the-impact-of-symptom-severity
#20
Carina Yvonne Heitmann, Katharina Feldker, Paula Neumeister, Leonie Brinkmann, Elisabeth Schrammen, Pienie Zwitserlood, Thomas Straube
Unintentional and uncontrollable processing of threat has been suggested to contribute to the pathology of social anxiety disorder (SAD). The present study investigated the neural correlates of processing task-irrelevant, highly ecologically valid, disorder-related stimuli as a function of symptom severity in SAD. Twenty-four SAD patients and 24 healthy controls (HC) performed a feature-based comparison task during functional magnetic resonance imaging, while task-irrelevant, disorder-related or neutral scenes were presented simultaneously at a different spatial position...
2017: NeuroImage: Clinical
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