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https://www.readbyqxmd.com/read/29750139/the-brown-incompleteness-scale-bincs-measure-development-and-initial-evaluation
#1
Christina L Boisseau, Nicholas J Sibrava, Sarah L Garnaat, Maria C Mancebo, Jane L Eisen, Steven A Rasmussen
Background: In recent years, incompleteness has received increased clinical attention as a core motivation underlying obsessive-compulsive spectrum disorders. Yet, assessment of incompleteness has relied almost exclusively on self-report and has assumed a unitary conceptualization of this phenomenon. Therefore, we sought to develop and validate a new multi-faceted clinician-administered measure of incompleteness. The Brown Incompleteness Scale (BINCS) consists of 21 items; each rated on a 5-point scale, with higher scores indicating a greater degree of incompleteness...
January 2018: Journal of Obsessive-compulsive and related Disorders
https://www.readbyqxmd.com/read/29722936/antibiotics-for-pandas-limited-evidence-review-and-putative-mechanisms-of-action
#2
Elisabetta Burchi, Stefano Pallanti
Objective: Antibiotics have been used extensively by clinicians to treat patients with PANDAS or PANS (pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections and pediatric acute-onset neuropsychiatric syndrome, respectively). This review examines the best-quality evidence supporting the practice-based use of antibiotics in these psychiatric conditions. Data Sources: PubMed was searched for English-language articles published between January 1994 and July 2017 using the search terms [PANDAS OR PANS OR new-onset pediatric OCD] AND [antibiotics OR macrolides OR beta-lactams]...
May 3, 2018: Primary Care Companion to CNS Disorders
https://www.readbyqxmd.com/read/29627697/are-the-components-of-social-reciprocity-transdiagnostic-across-pediatric-neurodevelopmental-disorders-evidence-for-common-and-disorder-specific-social-impairments
#3
Alexandra Sturm, Michelle Rozenman, Susanna Chang, James J McGough, James T McCracken, John C Piacentini
Deficits in social communication are a core feature of autism spectrum disorder (ASD), yet significant social problems have been observed in youth with many neurodevelopmental disorders. In this preliminary investigation, we aimed to explore whether domains of social reciprocity (i.e., social communication, social cognition, social awareness, social motivation, and restricted and repetitive behaviors) represent transdiagnostic traits. These domains were compared across youth ages 7-17 with obsessive-compulsive disorder (OCD; N = 32), tic disorders (TD; N = 20), severe mood dysregulation (N = 33) and autism spectrum disorder (N = 35)...
March 29, 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29568212/effectiveness-of-cognitive-behavioral-therapy-for-individuals-with-autism-spectrum-disorders-and-comorbid-obsessive-compulsive-disorder-a-review-of-the-research
#4
Leman Kaniturk Kose, Lise Fox, Eric A Storch
Autism spectrum disorders (ASD) and obsessive-compulsive disorder (OCD) are highly comorbid, precipitating an urgent need to identify evidence-based practices that might be used to address this comorbidity exclusively. The aim of this study was to conduct a review of intervention research and clinical reports to examine the use of cognitive behavioral therapy (CBT) with individuals who have comorbid ASD and OCD. Based on the pre-determined review inclusion criteria, 11 studies were included in the review: three randomized control trials (RCT), one case controlled study, two single subject experimental designs, and five case studies...
February 2018: Journal of Developmental and Physical Disabilities
https://www.readbyqxmd.com/read/29505902/the-genetic-architecture-of-schizophrenia-bipolar-disorder-obsessive-compulsive-disorder-and-autism-spectrum-disorder
#5
Kevin S O'Connell, Nathaniel W McGregor, Christine Lochner, Robin Emsley, Louise Warnich
Considerable evidence suggests that autism spectrum disorders (ASD), schizophrenia (SCZ), bipolar disorder (BD) and obsessive-compulsive disorder (OCD) share a common molecular aetiology, despite their unique clinical diagnostic criteria. The aim of this study was therefore to determine and characterise the common and unique molecular architecture of ASD, SCZ, BD and OCD. Gene lists were obtained from previously published studies for ASD, BD, SCZ and for OCD. Genes identified to be common to all disorders, or unique to one specific disorder, were included for enrichment analyses using the web-server tool Enrichr...
April 2018: Molecular and Cellular Neurosciences
https://www.readbyqxmd.com/read/29396406/dlgap1-knockout-mice-exhibit-alterations-of-the-postsynaptic-density-and-selective-reductions-in-sociability
#6
M P Coba, M J Ramaker, E V Ho, S L Thompson, N H Komiyama, S G N Grant, J A Knowles, S C Dulawa
The scaffold protein DLGAP1 is localized at the post-synaptic density (PSD) of glutamatergic neurons and is a component of supramolecular protein complexes organized by PSD95. Gain-of-function variants of DLGAP1 have been associated with obsessive-compulsive disorder (OCD), while haploinsufficient variants have been linked to autism spectrum disorder (ASD) and schizophrenia in human genetic studies. We tested male and female Dlgap1 wild type (WT), heterozygous (HT), and knockout (KO) mice in a battery of behavioral tests: open field, dig, splash, prepulse inhibition, forced swim, nest building, social approach, and sucrose preference...
February 2, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29343228/problematic-internet-use-and-psychiatric-co-morbidity-in-a-population-of-japanese-adult-psychiatric-patients
#7
Hille T de Vries, Takashi Nakamae, Kenji Fukui, Damiaan Denys, Jin Narumoto
BACKGROUND: Many studies reported the high prevalence of problematic internet use (PIU) among adolescents (13-50%), and PIU was associated with various psychiatric symptoms. In contrast, only a few studies investigated the prevalence among the adult population (6%). This study aimed to investigate the prevalence of PIU and psychiatric co-morbidity among adult psychiatric patients. METHODS: Three hundred thirty-three adult psychiatric patients were recruited over a 3-month period...
January 17, 2018: BMC Psychiatry
https://www.readbyqxmd.com/read/29327359/contact-sensitization-in-dental-technicians-with-occupational-contact-dermatitis-data-of-the-information-network-of-departments-of-dermatology-ivdk-2001-2015
#8
Annice Heratizadeh, Thomas Werfel, Steffen Schubert, Johannes Geier
BACKGROUND: Dental technicians (DTs) are at increased risk for allergic contact sensitization. OBJECTIVES: To assess the current spectrum of occupational sensitization in DTs with occupational contact dermatitis (OCD). METHODS: A retrospective analysis of Information Network of Departments of Dermatology patch test data from the years 2001-2015 concerning DTs with OCD was performed. RESULTS: Patients of the study group (226 DTs with OCD) were significantly more often diagnosed with allergic contact dermatitis (37...
April 2018: Contact Dermatitis
https://www.readbyqxmd.com/read/29169826/striatal-structure-and-its-association-with-n-acetylaspartate-and-glutamate-in-autism-spectrum-disorder-and-obsessive-compulsive-disorder
#9
Jilly Naaijen, Marcel P Zwiers, Natalie J Forde, Steven Cr Williams, Sarah Durston, Daniel Brandeis, Jeffrey C Glennon, The Tactics Consortium, Barbara Franke, David J Lythgoe, Jan K Buitelaar
Autism spectrum disorders (ASD) and obsessive compulsive disorder (OCD) are often comorbid and are associated with changes in striatal volumes and N-Acetylaspartate (NAA) and glutamate levels. Here, we investigated the relation between dorsal striatal volume and NAA and glutamate levels. We additionally compared striatal volume and shape between ASD, OCD and controls. T1-weighted magnetic resonance (MR) images, proton spectra (1H-MRS) in the left striatum, and phenotypic information were collected from 54 children with ASD, 32 with OCD, and 56 controls (aged 8-13 years) in a four-site study...
January 2018: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29167833/disorder-specific-and-shared-brain-abnormalities-during-vigilance-in-autism-and-obsessive-compulsive-disorder
#10
Christina O Carlisi, Luke Norman, Clodagh M Murphy, Anastasia Christakou, Kaylita Chantiluke, Vincent Giampietro, Andrew Simmons, Michael Brammer, Declan G Murphy, David Mataix-Cols, Katya Rubia
Background: Autism spectrum disorder (ASD) and obsessive-compulsive disorder (OCD) are often comorbid and share similarities across some cognitive phenotypes, including certain aspects of attention. However, no functional magnetic resonance imaging studies have compared the underlying neural mechanisms contributing to these shared phenotypes. Methods: Age- and IQ-matched boys (11-17 years old) with ASD ( n = 20), boys with OCD ( n = 20), and healthy control boys ( n = 20) performed a parametrically modulated psychomotor vigilance functional magnetic resonance imaging task...
November 2017: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
https://www.readbyqxmd.com/read/29082426/anxiety-disorders-and-obsessive-compulsive-disorder-in-individuals-with-autism-spectrum-disorder
#11
REVIEW
Valentina Postorino, Connor M Kerns, Giacomo Vivanti, Jessica Bradshaw, Martina Siracusano, Luigi Mazzone
PURPOSE OF REVIEW: This review aims to synthesize the most recent research on anxiety disorders and obsessive-compulsive disorder (OCD) in individuals with autism spectrum disorder (ASD) and discuss the relationship between these conditions and challenges for assessment. Furthermore, implications for treatment and future directions are discussed. RECENT FINDINGS: Research suggests that anxiety disorders and OCD are highly prevalent in individuals with ASD. However, the significant overlap of ASD features with anxiety and OCD symptomology makes differential diagnosis of these disorders particularly challenging...
October 30, 2017: Current Psychiatry Reports
https://www.readbyqxmd.com/read/29052999/impulsivity-and-compulsivity-in-internet-gaming-disorder-a-comparison-with-obsessive-compulsive-disorder-and-alcohol-use-disorder
#12
COMPARATIVE STUDY
Yeon-Jin Kim, Jae A Lim, Ji Yoon Lee, Sohee Oh, Sung Nyun Kim, Dai Jin Kim, Jong Eun Ha, Jun Soo Kwon, Jung-Seok Choi
Background and aims Internet gaming disorder (IGD) is characterized by a loss of control and a preoccupation with Internet games leading to repetitive behavior. We aimed to compare the baseline neuropsychological profiles in IGD, alcohol use disorder (AUD), and obsessive-compulsive disorder (OCD) in the spectrum of impulsivity and compulsivity. Methods A total of 225 subjects (IGD, N = 86; AUD, N = 39; OCD, N = 23; healthy controls, N = 77) were administered traditional neuropsychological tests including Korean version of the Stroop Color-Word test and computerized neuropsychological tests, including the stop signal test (SST) and the intra-extra dimensional set shift test (IED)...
December 1, 2017: Journal of Behavioral Addictions
https://www.readbyqxmd.com/read/29046136/phenotype-development-in-adolescents-with-tourette-syndrome-a-large-clinical-longitudinal-study
#13
Camilla Groth, Nanette Mol Debes, Liselotte Skov
Tourette syndrome (TS) is a neurodevelopmental disorder characterized by frequent comorbidities and a wide spectrum of phenotype presentations. This study aimed to describe the development of phenotypes in TS and tic-related impairment in a large longitudinal study of 226 children and adolescents followed up after 6 years. The participants were clinically examined to assess tic severity and impairment, obsessive compulsive disorder (OCD), and attention-deficit/hyperactivity disorder (ADHD). The development in phenotypes changed toward less comorbidity with 40% TS-only (no OCD or ADHD) (TS without OCD or ADHD) at baseline and 55% at follow-up...
November 2017: Journal of Child Neurology
https://www.readbyqxmd.com/read/29045575/shared-and-disorder-specific-neurocomputational-mechanisms-of-decision-making-in-autism-spectrum-disorder-and-obsessive-compulsive-disorder
#14
Christina O Carlisi, Luke Norman, Clodagh M Murphy, Anastasia Christakou, Kaylita Chantiluke, Vincent Giampietro, Andrew Simmons, Michael Brammer, Declan G Murphy, David Mataix-Cols, Katya Rubia
Autism spectrum disorder (ASD) and obsessive-compulsive disorder (OCD) often share phenotypes of repetitive behaviors, possibly underpinned by abnormal decision-making. To compare neural correlates underlying decision-making between these disorders, brain activation of boys with ASD (N = 24), OCD (N = 20) and typically developing controls (N = 20) during gambling was compared, and computational modeling compared performance. Patients were unimpaired on number of risky decisions, but modeling showed that both patient groups had lower choice consistency and relied less on reinforcement learning compared to controls...
December 1, 2017: Cerebral Cortex
https://www.readbyqxmd.com/read/28975826/prevalence-and-severity-of-osteochondrosis-of-the-free-thoracic-vertebra-in-three-modern-broiler-strains-and-the-athens-canadian-random-bred-control-broiler
#15
Laura R Chen, M Mitsu Suyemoto, Albarra H Sarsour, H Alejandro Cordova, Edgar O Oviedo-Rondón, H John Barnes, Luke B Borst
Osteochondrosis (OCD) results from a disturbance of endochondral ossification in articular cartilage and is an important cause of lameness in several animal species, including chickens. OCD lesions in the free thoracic vertebra (FTV) of chickens are essential to the pathogenesis of pathogenic Enterococcus cecorum. The goal of this study was to determine the prevalence of OCD in the FTV among three modern broiler chicken crosses (strains A/A, A/B, and C/C) and Athens Canadian Random Bred (ACRB) chickens, which served as the control group...
April 2018: Avian Pathology: Journal of the W.V.P.A
https://www.readbyqxmd.com/read/28950925/psychiatric-epidemiology-and-disaster-exposure-in-australia
#16
L Reifels, K Mills, M L A Dückers, M L O'Donnell
AIMS: To examine the lifetime prevalence and risk of psychiatric disorders associated with natural and man-made disaster exposure in Australia. METHODS: We utilised data from a nationally representative population survey (N = 8841) which were analysed through univariate and multivariate logistic regression in order to examine the full spectrum of Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) affective, anxiety and substance use disorders associated with exposure to natural and man-made disaster...
September 27, 2017: Epidemiology and Psychiatric Sciences
https://www.readbyqxmd.com/read/28948967/corticostriatal-circuit-defects-in-hoxb8-mutant-mice
#17
N Nagarajan, B W Jones, P J West, R E Marc, M R Capecchi
Hoxb8 mutant mice exhibit compulsive grooming and hair removal dysfunction similar to humans with the obsessive-compulsive disorder (OCD)-spectrum disorder, trichotillomania. As, in the mouse brain, the only detectable cells that label with Hoxb8 cell lineage appear to be microglia, we suggested that defective microglia cause the neuropsychiatric disorder. Does the Hoxb8 mutation in microglia lead to neural circuit dysfunctions? We demonstrate that Hoxb8 mutants contain corticostriatal circuit defects. Golgi staining, ultra-structural and electrophysiological studies of mutants reveal excess dendritic spines, pre- and postsynaptic structural defects, long-term potentiation and miniature postsynaptic current defects...
September 26, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/28885367/compulsive-skin-picking-behavior-after-deep-brain-stimulation-in-a-patient-with-refractory-obsessive-compulsive-disorder-a-case-report
#18
Chun-Hung Chang, Shin-Yuan Chen, Sheng-Tzung Tsai, Hsin-Chi Tsai
RATIONAL: The therapeutic effect of deep brain stimulation (DBS) for refractory obsessive-compulsive disorder (OCD) has been studied, but complications after this treatment have rarely been noted. PATIENT CONCERNS: A 28-year-old man with treatment-resistant OCD received bilateral ventral capsule/ventral striatum stimulation for 12 months. DIAGNOSIS: Compulsive skin-picking behavior and infection were noted following 12-month DBS treatment...
September 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28882118/separating-obsessive-compulsive-disorder-from-the-self-a-qualitative-study-of-family-member-perceptions
#19
Rebecca Pedley, Penny Bee, Katherine Berry, Alison Wearden
BACKGROUND: Obsessive-compulsive disorder (OCD) is a condition which can have major effects on the life of both the sufferer and their family members. Previous research has shown that the impact of illness on family members is related to their conceptualisation of the illness. In the present study we used qualitative methods to explore illness perceptions in family members of people with OCD. METHOD: Fourteen family members of people meeting diagnostic criteria for OCD within the previous year took part in a semi-structured interview...
September 7, 2017: BMC Psychiatry
https://www.readbyqxmd.com/read/28861007/cognitive-behavioral-therapy-for-obsessive-compulsive-disorder-with-and-without-autism-spectrum-disorder-gray-matter-differences-associated-with-poor-outcome
#20
Aki Tsuchiyagaito, Yoshiyuki Hirano, Kenichi Asano, Fumiyo Oshima, Sawako Nagaoka, Yoshitake Takebayashi, Koji Matsumoto, Yoshitada Masuda, Masaomi Iyo, Eiji Shimizu, Akiko Nakagawa
Cognitive behavioral therapy (CBT) is an effective treatment for obsessive-compulsive disorder (OCD) and is also applicable to patients with both OCD and autism spectrum disorder (ASD). However, previous studies have reported that CBT for patients with both OCD and ASD might be less effective than for patients with OCD alone. In addition, there is no evidence as to why autistic traits might be risk factors. Therefore, we investigated whether comorbidity between ASD and OCD may significantly affect treatment outcome and discovered predictors of CBT outcomes using structural magnetic resonance imaging (MRI) data...
2017: Frontiers in Psychiatry
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