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https://www.readbyqxmd.com/read/28075581/antagonizing-nod2-signaling-with-conjugates-of-paclitaxel-and-muramyl-dipeptide-derivatives-sensitizes-paclitaxel-therapy-and-significantly-prevents-tumor-metastasis
#1
Yi Dong, Suhua Wang, Chunting Wang, Zihua Li, Yao Ma, Gang Liu
A non-cleavable paclitaxel (PTX) and N-acetyl-muramyl-L-alanyl-D-isoglutamine (MDP) derivative conjugate, 22 (DY-16-43), and its analogues were prepared and characterized as antagonists of NOD2 signaling. This conjugate enhanced the anti-tumor and anti-metastatic efficacy of PTX in Lewis lung carcinoma (LLC) tumor-bearing mice. This work first describes a molecular strategy that enables the sensitization of a chemotherapeutic response via antagonizing NOD2 inflammatory signaling and suggests NOD2 antagonist as potential adjunct in treating non-small-cell lung cancer (NSCLC)...
January 11, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28072622/170tm-edtmp-a-prospective-alternative-of-89srcl2-for-theranostic-treatment-of-metastatic-bone-pain
#2
Tapas Das, Ajit Shinto, Koramadai Karuppuswamy Kamaleshwaran, Sharmila Banerjee
We have earlier reported the potential of Tm-EDTMP as an alternative cost-effective radiopharmaceutical of SrCl2 for bone pain palliation application. Encouraging results obtained in the radiochemical studies and biological evaluations in animal model have prompted us to initiate the clinical study to evaluate the potential of Tm-EDTMP in human cancer patients. The serial scintigraphic images represent the whole-body scans of a patient (68 years old woman) with skeletal metastases of carcinoma of the breast origin recorded after administering 370 MBq (10 mCi) of Tm-EDTMP at different post-administration time points along with the pre-therapy images recorded with Tc-MDP in the same patient...
January 9, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28047608/su-d-brb-05-quantum-learning-for-knowledge-based-response-adaptive-radiotherapy
#3
I El Naqa, R Ten
PURPOSE: There is tremendous excitement in radiotherapy about applying data-driven methods to develop personalized clinical decisions for real-time response-based adaptation. However, classical statistical learning methods lack in terms of efficiency and ability to predict outcomes under conditions of uncertainty and incomplete information. Therefore, we are investigating physics-inspired machine learning approaches by utilizing quantum principles for developing a robust framework to dynamically adapt treatments to individual patient's characteristics and optimize outcomes...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28034704/antioxidants-taken-orally-prior-to-diagnostic-radiation-exposure-can-prevent-dna-injury
#4
Nivethan Velauthapillai, Joe Barfett, Hussein Jaffer, David Mikulis, Kieran Murphy
PURPOSE: To evaluate efficacy of oral antioxidant treatment given to patients before radiologic procedures in reducing x-ray-induced DNA damage. MATERIALS AND METHODS: In a single-center prospective controlled trial, antioxidant treatment with 2 g ascorbate, 1.2 g N-acetylcysteine, 600 mg lipoic acid, and 30 mg beta carotene was given to 5 consecutive participants before undergoing clinically indicated technetium-99m methylene diphosphonate ((99m)Tc MDP) bone scans for cancer staging...
December 26, 2016: Journal of Vascular and Interventional Radiology: JVIR
https://www.readbyqxmd.com/read/28033224/skeletal-scintigraphy-in-radiation-induced-fibrosis-with-lymphedema
#5
Jieqi Wang, Arya M Iranmanesh, M Elizabeth Oates
Despite increasing reliance on CT, MRI, and FDG PET/CT for oncological imaging, whole-body skeletal scintigraphy remains a frontline modality for staging and surveillance of osseous metastatic disease. We present a 54-year-old woman with metastatic breast cancer who received palliative external-beam radiation to the left ilium. Serial follow-up Tc-MDP bone scans demonstrated progressive soft-tissue uptake in her left lower extremity, extending from thigh to leg, with associated enlargement and skin thickening, consistent with lymphedema related to radiation-induced fibrosis...
December 28, 2016: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28005642/tumorlike-pigmented-villonodular-synovitis-with-atypical-location-appearance-on-3-phase-99mtc-mdp-bone-scan
#6
Qian Hua, Jianming Ni
Pigmented villonodular synovitis (PVNS) is a proliferative disorder of unknown etiology that originates from the synovial membranes of joints. Some PVNS lesions have been misdiagnosed as malignancy due to their tumorlike imaging findings. There are few reports of PVNS on nuclear 3-phase bone imaging. However, 3-phase Tc-MDP bone scan can offer additional information about the dynamic flow features of the lesion, which may do help in differential benign and malignant. The present report describes 3-phase bone imaging in a surgically proven case of PVNS with tumorlike appearance and atypical location...
December 21, 2016: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28004792/nod2-dependent-neutrophil-recruitment-is-required-for-early-protective-immune-responses-against-infectious-litomosoides-sigmodontis-l3-larvae
#7
Jesuthas Ajendra, Sabine Specht, Sebastian Ziewer, Andrea Schiefer, Kenneth Pfarr, Marijo Parčina, Thomas A Kufer, Achim Hoerauf, Marc P Hübner
Nucleotide-binding oligomerization domain-containing protein 2 (NOD2) recognizes muramyl dipeptide (MDP) of bacterial cell walls, triggering NFκB-induced pro-inflammation. As most human pathogenic filariae contain Wolbachia endobacteria that synthesize the MDP-containing cell wall precursor lipid II, NOD2's role during infection with the rodent filaria Litomosoides sigmodontis was investigated. In NFκB reporter-cells, worm-extract containing Wolbachia induced NOD2 and NOD1. NOD2-deficient mice infected with L...
December 22, 2016: Scientific Reports
https://www.readbyqxmd.com/read/28000765/dipentaerythritol-penta-acrylate-phosphate-an-alternative-phosphate-ester-monomer-for-bonding-of-methacrylates-to-zirconia
#8
Ying Chen, Franklin R Tay, Zhicen Lu, Chen Chen, Mengke Qian, Huaiqin Zhang, Fucong Tian, Haifeng Xie
The present work examined the effects of dipentaerythritol penta-acrylate phosphate (PENTA) as an alternative phosphate ester monomer for bonding of methacrylate-based resins to yttria-stabilized tetragonal zirconia polycrystals (Y-TZP) and further investigated the potential bonding mechanism involved. Shear bond strength testing was performed to evaluate the efficacy of experimental PENTA-containing primers (5, 10, 15, 20 or 30 wt% PENTA in acetone) in improving resin-Y-TZP bond strength. Bonding without the use of a PENTA-containing served as the negative control, and a Methacryloyloxidecyl dihydrogenphosphate(MDP)-containing primer was used as the positive control...
December 21, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27992368/early-detection-of-rheumatoid-arthritis-in-rats-and-humans-with-99mtc-3prgd2-scintigraphy-imaging-synovial-neoangiogenesis
#9
Yu Wu, Guojian Zhang, Xiangcheng Wang, Zhenfang Zhao, Tao Wang, Xuemei Wang, Xiao-Feng Li
OBJECTIVES: To validate 99mTc-labeled arginylglycylaspartic acid (99mTc-3PRGD2) scintigraphy as a means to image synovial neoangiogenesis in joints afflicted by rheumatoid arthritis and to investigate its potential in the early detection and management of rheumatoid arthritis. METHODS: Rheumatoid arthritis and osteoarthritis were generated in Sprague Dawley rats by type II collagen immunization and papain injection, respectively. Rats were imaged with 99mTc-3PRGD2 and 99mTc- methyl diphosphonate (99mTc MDP)...
December 15, 2016: Oncotarget
https://www.readbyqxmd.com/read/27991595/pgrp-negatively-regulates-nod-mediated-cytokine-production-in-rainbow-trout-liver-cells
#10
Ju Hye Jang, Hyun Kim, Mi Jung Jang, Ju Hyun Cho
Pattern-recognition receptors (PRRs) initiate innate immunity via pathogen recognition. Recent studies suggest that signalling pathways downstream of different PRRs and their crosstalk effectively control immune responses. However, the cross-regulation among PRRs and its effects have yet to be fully described in fish. Here, we examined the crosstalk between OmPGRP-L1, a long form of PGRP in rainbow trout, and other PRRs during pathogenic infections. OmPGRP-L1 expression was increased in RTH-149 cells by iE-DAP and MDP, which are agonists of NOD1 and NOD2, respectively...
December 19, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27988825/milk-and-dairy-products-intake-is-associated-with-low-levels-of-lead-pb-in-workers-highly-exposed-to-the-metal
#11
Willian Robert Gomes, Paula Pícoli Devóz, Marília Ladeira Araújo, Bruno Lemos Batista, Fernando Barbosa, Gustavo Rafael Mazzaron Barcelos
Lead (Pb) is a toxic metal, frequently associated with occupational exposure, due to its widespread use in industry and several studies have shown high Pb levels in workers occupationally exposed to the metal. The aim of this study was to evaluate the influence of milk and dairy products (MDP) on Pb levels in blood (B-Pb), plasma (P-Pb), and urine (U-Pb), in workers from automotive battery industries in Brazil. The study included 237 male workers; information concerning diet and lifestyle were gathered through a questionnaire, and B-Pb, P-Pb, and U-Pb were determined by ICP-MS...
December 17, 2016: Biological Trace Element Research
https://www.readbyqxmd.com/read/27969264/efficacy-and-safety-of-onabotulinumtoxin-a-100u-for-treatment-of-urinary-incontinence-due-to-neurogenic-detrusor-overactivity-in-non-catheterising-multiple-sclerosis-patients
#12
P Denys, V Keppenne, A Kohan, B Egerdie, B Brucker, A Magyar, J Nicandro, B Jenkins, E Chartier-Kastler
OBJECTIFS: We evaluated the efficacy/safety of onabotulinumtoxin A 100U versus placebo for treatment of urinary incontinence (UI) due to neurogenic detrusor overactivity (NDO) in non-catheterising multiple sclerosis (MS) patients inadequately managed by≥1 anticholinergic. MéTHODES: A multicentre, double-blind study randomised patients 1:1 to onabotulinumtoxin A 100U (n=66) or placebo (n=78). Assessments (week 6 primary endpoint) included change from baseline in UI episodes (UIE)/day (primary endpoint), maximum cystometric capacity (MCC), maximum detrusor pressure (MDP) during first involuntary detrusor contraction (IDC), incontinence-quality of life (I-QOL) total summary score, and proportions of patients achieving 100% UIE reduction...
November 2016: Progrès en Urologie
https://www.readbyqxmd.com/read/27956797/ex-vivo-response-to-mucosal-bacteria-and-muramyl-dipeptide-in-inflammatory-bowel-disease
#13
Claudia Loganes, Erica Valencic, Alessia Pin, Elisa Marini, Stefano Martelossi, Samuele Naviglio, Luigina De Leo, Tarcisio Not, Lorenzo Monasta, Alberto Tommasini, Annalisa Marcuzzi
AIM: To evaluate how mucosal bacteria impact on the spontaneous and muramyl dipeptide (MDP)-induced inflammation in Crohn's disease (CD) and ulcerative colitis (UC). METHODS: Colonic mucosal biopsies were collected from children with active or remissive CD, UC and controls. Two tissue samples were taken from inflamed mucosal segments (in patients with active disease) or from non-inflamed mucosa [in patients in remission or in healthy controls (HC)]. Experiments were performed in the presence or absence of antibiotics, to assess whether the disease-associated microbiota can modulate the cytokine response ex vivo...
November 28, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/27955706/prevalence-of-herpes-simplex-virus-2-hsv-2-infection-and-associated-risk-factors-in-a-cohort-of-hiv-negative-women-in-durban-south-africa
#14
Brodie Daniels, Handan Wand, Gita Ramjee
BACKGROUND: Herpes Simplex Virus 2 (HSV-2) is one of the most common sexually transmitted infections (STIs) worldwide and is a risk factor for the acquisition and transmission of other STIs, including HIV. We determined the prevalence and predictors of HSV-2 infection among women screened for a HIV prevention trial in Durban, South Africa. Univariate and multivariate logistic and Cox regression models were used to determine the correlates and predictors of HSV-2 infection at enrolment and seroconversion during the study respectively...
December 12, 2016: BMC Research Notes
https://www.readbyqxmd.com/read/27922864/99mtc-mdp-uptake-in-diffuse-pleural-recurrences-of-pulmonary-neuroendocrine-carcinoma
#15
Taisong Wang, Wenli Qiao, Yan Xing, Jinhua Zhao
A 39-year-old woman with a history of pulmonary neuroendocrine carcinoma segmental palliative resection underwent a Tc-MDP bone scintigraphy to evaluate possible osseous metastases. The static images revealed diffuse elevated activity in the left hemithorax, more prominent in the lower thorax, which is suggestive of malignant pleural effusion. However, SPECT/CT images showed that the elevated activity was from pleura-based soft tissue masses, which were confirmed as recurrent tumor pathologically after biopsy...
December 3, 2016: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/27902795/genome-wide-association-study-identifies-candidate-loci-underlying-agronomic-traits-in-a-middle-american-diversity-panel-of-common-bean
#16
Samira Mafi Moghaddam, Sujan Mamidi, Juan M Osorno, Rian Lee, Mark Brick, James Kelly, Phillip Miklas, Carlos Urrea, Qijian Song, Perry Cregan, Jane Grimwood, Jeremy Schmutz, Phillip E McClean
Common bean ( L.) breeding programs aim to improve both agronomic and seed characteristics traits. However, the genetic architecture of the many traits that affect common bean production are not completely understood. Genome-wide association studies (GWAS) provide an experimental approach to identify genomic regions where important candidate genes are located. A panel of 280 modern bean genotypes from race Mesoamerica, referred to as the Middle American Diversity Panel (MDP), were grown in four US locations, and a GWAS using >150,000 single-nucleotide polymorphisms (SNPs) (minor allele frequency [MAF] ≥ 5%) was conducted for six agronomic traits...
November 2016: Plant Genome
https://www.readbyqxmd.com/read/27895867/detection-of-second-mesiobuccal-canals-in-maxillary-first-molars-using-a-new-angle-of-cone-beam-computed-tomography
#17
Ali Murat Aktan, Cihan Yildirim, Emre Culha, Erhan Demir, Mehmet Ertugrul Ciftci
BACKGROUND: The localization of the additional canal orifice is one of the primary factors influencing the success of endodontic treatment. To deal with this problem, several techniques that each have their own advantages and disadvantages have been discussed in the literature. OBJECTIVES: The aim of the present in vitro study was to review a new approach to localizing second mesiobuccal (MB2) canals in maxillary first molars using cone beam computed tomography (CBCT)...
October 2016: Iranian Journal of Radiology: a Quarterly Journal Published By the Iranian Radiological Society
https://www.readbyqxmd.com/read/27895399/altered-pattern-of-tumor-necrosis-factor-alpha-production-in-peripheral-blood-monocytes-from-crohn-s-disease
#18
Claudia Loganes, Alessia Pin, Samuele Naviglio, Martina Girardelli, Anna Monica Bianco, Stefano Martelossi, Alberto Tommasini, Elisa Piscianz
AIM: To evaluate the inflammatory state in Crohn's disease (CD) patients and correlate it with genetic background and microbial spreading. METHODS: By means of flow cytometry, production of tumor necrosis factor-alpha (TNF-α) was measured in peripheral blood monocytes from patients suffering from CD, ulcerative colitis (UC) and in healthy subjects after stimulation of the NOD2 and TLR pathways. CD patients were genotyped for the three most common NOD2 variants (R702W, G908R and L1007Pfs*2) and basal production of TNF-α was correlated to NOD2 genotype...
November 7, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/27890356/does-8-methacryloxyoctyl-trimethoxy-silane-8-mots-improve-initial-bond-strength-on-lithium-disilicate-glass-ceramic
#19
Yukinori Maruo, Goro Nishigawa, Kumiko Yoshihara, Shogo Minagi, Takuya Matsumoto, Masao Irie
OBJECTIVES: Dental ceramic surfaces are modified with silane coupling agents, such as γ-methacryloxypropyl trimethoxy silane (γ-MPTS), to improve bond strength. For bonding between lithium disilicate glass ceramic and resin cement, the objective was to investigate if 8-methacryloxyoctyl trimethoxy silane (8-MOTS) could yield a similar performance as the widely used γ-MPTS. METHODS: One hundred and ten lithium disilicate glass ceramic specimens were randomly divided into 11 groups (n=10) according to pretreatment regime...
November 24, 2016: Dental Materials: Official Publication of the Academy of Dental Materials
https://www.readbyqxmd.com/read/27874293/improved-stability-of-solid-dispersions-of-manidipine-with-polyethylene-glycol-4000-copovidone-blends-application-of-ternary-phase-diagram
#20
Benchawan Chamsai, Sontaya Limmatvapirat, Srisagul Sungthongjeen, Pornsak Sriamornsak
CONTEXT: Manidipine (MDP) is generally used clinically as an antihypertensive agent; however, the bioavailability of orally administered MDP is limited due to their very low water solubility. OBJECTIVE: The objectives of this research were, therefore, to increase the solubility of MDP by the formation of ternary solid dispersions (tSD) with polyethylene glycol 4000 (PEG4000) and copovidone and to improve their stability. METHODS: Solid ternary phase diagram was constructed to find homogeneous solid dispersion region after melting and solidifying at low temperature with different quenching substances...
December 7, 2016: Drug Development and Industrial Pharmacy
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