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Laura Fernández-García, Felipe Fernandez-Cuenca, Lucía Blasco, Rafael López-Rojas, Anton Ambroa, María Lopez, Álvaro Pascual, Germán Bou, María Tomás
The molecular mechanisms of tolerance and persistence associated with several compounds in Acinetobacter baumannii clinical isolates are unknown. Using transcriptomic and phenotypic studies, we found a link between mechanisms of bacterial tolerance to chlorhexidine and the development of persistence in the presence of imipenem in an A. baumannii strain belonging to clinical clone ST-2 (OXA-24 β-lactamase and AbkAB toxin-antitoxin [TA] system carried in a plasmid). Interestingly, the strain A. baumannii ATCC 17978 (AbkAB TA system from plasmid) showed persistence in the presence of imipenem and chlorhexidine...
May 2018: Antimicrobial Agents and Chemotherapy
Sistema Español de Notificación En Seguridad En Anestesia Y Reanimación Sensar
Surgical wound infection is one of the main sources of postoperative morbidity/mortality. Skin preparation with an antiseptic agent such as chlorhexidine alcohol solution is an effective method to reduce the incidence of surgical wound infections. Nevertheless, the use of alcohol solutions is associated with some risk as they are inflammable products. We report a case of a 51-year-old male who suffered an extensive burn associated with concurrent use of electrocautery and clorhexidine alcohol solution.
March 2018: Revista Española de Anestesiología y Reanimación
Lucía García-Martínez, Rubén Martín-Payo, Alejandro Pelaz-García, Matilde Sierra-Vega, Luis Manuel Junquera-Gutiérrez
PURPOSE: To evaluate the effectiveness of a health education programme on knowledge and reduction of the risk factors for bisphosphonate-related osteonecrosis of the jaw. METHODS: An experimental study control group without intervention was performed with 60 subjects who had started treatment with bisphosphonates in the University Hospital of León from October to December 2014. Patients in the experimental group received a structured education intervention in two sessions...
June 2, 2017: Enfermería Clínica
Janislei Gislei Dorociaki Stocco, Hellen Hoers, Franciele Soares Pott, Karla Crozeta, Dulce Aparecida Barbosa, Marineli Joaquim Meier
OBJECTIVE: to evaluate the effectiveness and safety in the use of second-generation central venous catheters impregnated in clorhexidine and silver sulfadiazine when compared with other catheters, being them impregnated or not, in order to prevent the bloodstream infection prevention. METHOD: systematic review with meta-analysis. Databases searched: MEDLINE, EMBASE, CINAHL, LILACS/SciELO, Cochrane CENTRAL; search in Congress Proceedings and records from Clinical Trials...
August 8, 2016: Revista Latino-americana de Enfermagem
Tânia Curiao, Emmanuela Marchi, Denis Grandgirard, Ricardo León-Sampedro, Carlo Viti, Stephen L Leib, Fernando Baquero, Marco R Oggioni, José Luis Martinez, Teresa M Coque
BACKGROUND: Biocides and antibiotics are used to eradicate or prevent the growth of microbial species on surfaces (occasionally on catheters), or infected sites, either in combination or sequentially, raising concerns about the development of co-resistance to both antimicrobial types. The effect of such compounds on Salmonella enterica, a major food-borne and zoonotic pathogen, has been analysed in different studies, but only few works evaluated its biological cost, and the overall effects at the genomic and transcriptomic levels associated with diverse phenotypes resulting from biocide exposure, which was the aim of this work...
July 13, 2016: BMC Genomics
Mirjana Popovska, Jasmin Fidovski, Sonja Mindova, Katerina Dirjanska, Stevica Ristoska, Emilija Stefanovska, Vera Radojkova-Nikolovska, Kristina Mitic, Biljana Rusevska
The therapy of erosive lichen planus (ELP) has been particular problem in the treatment of oral lesions. This case of ELP in male patient 29 years old was treated with topic application of the NBF gingival gel, three times a day after meal, previously rinsed with Clorhexidine gluconate 0.12%. After 5 days of treatment, initial improvements were recorded, and after two weeks of application of the NBF gingival gel we observed significant improvement. Clinical monitoring after the fifth day showed mild epithelialization of the eroded mucosa, yet still present erythematous base of the lesion...
March 15, 2016: Open Access Macedonian Journal of Medical Sciences
Cristina Carral, Fernando Muñoz, María Permuy, Antonio Liñares, Michel Dard, Juan Blanco
OBJECTIVE: The aim of the present study was to evaluate the effect of a titanium brush and chemical agents following surgical treatment of experimental peri-implantitis. MATERIAL AND METHODS: Six implants were installed in the mandible of eight beagle dogs (unit of analysis) 3 months after tooth extraction. Experimental peri-implantitis was induced 3 months later. The defects were randomly allocated in three treatment groups: (a) TiBrush(™)  + sodium hypochlorite + chlorhexidine (TBH), (b) TiBrush(™)  + chlorhexidine (TB), (c) an ultrasonic device + chlorhexidine (US)...
August 2016: Journal of Clinical Periodontology
Angélica Díaz, Luis J del Valle, David Tugushi, Ramaz Katsarava, Jordi Puiggalí
Electrospun scaffolds from an amino acid containing poly(ester urea) (PEU) were developed as promising materials in the biomedical field and specifically in tissue engineering applications. The selected poly(ester urea) was obtained with a high yield and molecular weight by reaction of phosgene with a bis(α-aminoacyl)-α,ω-diol-diester monomer. The polymer having L-leucine, 1,6-hexanediol and carbonic acid units had a semicrystalline character and relatively high glass transition and melting temperatures...
January 2015: Materials Science & Engineering. C, Materials for Biological Applications
María Guembe, María Jesús Pérez Granda, Raquel Cruces, Pablo Martín-Rabadán, Emilio Bouza
This study assessed in an in vitro model the effect of 2% alcohol clorhexidine for the disinfection of stickers used for intravenous line identification. Nonadhesive sticker sides were associated with higher numbers of colony-forming units when manipulation was performed without 2% alcohol clorhexidine disinfection. Future clinical studies are needed to validate these data and design policies for daily sticker disinfection.
January 2015: American Journal of Infection Control
Ozlem Acar, Duygu Tuncer, Bulem Yuzugullu, Cigdem Celik
PURPOSE: The purpose of this study is to evaluate if pre-treatment with desensitizers have a negative effect on microtensile bond strength before cementing a restoration using recently introduced self-adhesive resin cement to dentin. MATERIALS AND METHODS: Thirty-five human molars' occlusal surfaces were ground to expose dentin; and were randomly grouped as (n=5); 1) Gluma-(Glutaraldehyde/HEMA) 2) Aqua-Prep F-(Fluoride), 3) Bisblock-(Oxalate), 4) Cervitec Plus-(Clorhexidine), 5) Smart protect-(Triclosan), 6) Nd:YAG laser, 7) No treatment (control)...
April 2014: Journal of Advanced Prosthodontics
Victor Quintas, Isabel Prada-López, Juan Carlos Prados-Frutos, Inmaculada Tomás
OBJECTIVES: This study aims to evaluate the in situ antibacterial activity of a mouthwash containing essential oils (M-EO) on undisturbed de novo plaque-like biofilm (PL-biofilm) up to 7 h after its application. PATIENTS AND METHODS: An appliance was designed to hold six glass disks on the buccal sides of the lower teeth, allowing PL-biofilm growth. Fifteen healthy volunteers wore the appliance for 48 h and then performed a M-EO. Disks were removed after 30 s and at 1, 3, 5, and 7 h later...
January 2015: Clinical Oral Investigations
Johanna Osorio, Diana Álvarez, Robinson Pacheco, Carlos A Gómez, Abner Lozano
BACKGROUND: Central line-associated bloodstream infections (CLABSI) related to insertion and device care in intensive care units are frequent and preventable events. AIM: To evaluate the reduction in the rate of CLABSI through implementation of an insertion bundle. METHODS: A study was conducted in the Adult-ICU at the University Hospital of Neiva comparing a pre-interventional period with an interventional one, each lasting 6 months; the intervention consisting of implementing a bundle of measures for the insertion of central venous catheters (CVC)...
October 2013: Revista Chilena de Infectología: órgano Oficial de la Sociedad Chilena de Infectología
Jorunn Hommelstad, Anita Madsø, Per Kristian Eide
BACKGROUND: Shunt infection markedly impairs the clinical result of shunt surgery. The infection rate can be reduced by dedicated protocols. This study was undertaken to determine the efficacy of introducing a perioperative protocol for control of shunt infections. METHOD: The shunt infection rate and risk factors for shunt infection were determined for two periods, namely the period 2001-2002 (Patient Material A), and the period 2005-2008 (Patient Material B). The perioperative protocol was introduced in 2005 before the second period...
March 2013: Acta Neurochirurgica
K Atahan, A Cokmez, M Bekoglu, E Durak, C Tavusbay, E Tarcan
AIM: Intravenous catheters have become one of the essential tools of modern medicine. Preventive measures taken while the catheter is being inserted or in place can provide a significant reduction in catheter-related infections and bacteremia/sepsis.This study aims to evaluate whether the patient's age and gender, the presence of malignancy and coexisting diseases, catheter duration, use of total parenteral nutrition solution, blood products, and antibiotics as well as antiseptics applied while attaching the central venous catheter (chlorhexidine and povidone-iodine) affect the development of catheter colonization and catheter-related bloodstream infections in patients with central venous catheters...
2012: Bratislavské Lekárske Listy
Istemi Han Celik, Serife Suna Oguz, Ugur Dilmen
An infant was cleansed with 2% clorhexidine gluconate (CHG) because of repeated sepsis episodes from skin colonization. Asymptomatic hyperchloremia ensued, most likely associated with CHG therapy. Fourty-eight hours after CHG therapy withdrawal, serum chloride levels returned to normal. Hyperchloremia may be a reversible adverse effect of extensive use of CHG.
January 2014: Pediatric Dermatology
Ronald Ordinola-Zapata, Clovis M Bramante, Roberto Brandão Garcia, Flaviana Bombarda de Andrade, Norberti Bernardineli, Ivaldo Gomes de Moraes, Marco A H Duarte
OBJECTIVES: To evaluate if the incorporation of antimicrobial compounds to chelating agents or the use of chelating agents with antimicrobial activity as 7% maleic acid and peracetic acid show similar disinfection ability in comparison to conventional irrigants as sodium hypochlorite or iodine potassium iodide against biofilms developed on dentin. MATERIALS AND METHODS: The total bio-volume of live cells, the ratio of live cells and the substratum coverage of dentin infected intra-orally and treated with the irrigant solutions: MTAD, Qmix, Smear Clear, 7% maleic acid, 2% iodine potassium iodide, 4% peracetic acid, 2...
May 2013: Acta Odontologica Scandinavica
Gabriela Dimitriu
There are few new methods conferred an efficient prevention in order to reduce the incidence of endometritis after cesarean section. The study aim was to compare two techniques using in post partum post-cesarean endometritis prevention: local (vaginal) intra-partum application of 0.25% Clorhexidine solution during elective cesarean deliveries vs intraoperative cesarean section antibioprevention with 2g second generation cephalosporin administered by intravenous injection after clamping the umbilical cord.
April 2010: Revista Medico-chirurgicală̆ a Societă̆ţ̜ii de Medici ş̧i Naturaliş̧ti Din Iaş̧i
S I Gazhva, A I Voronina, O V Shkarednaia
The article highlights the data about local immunity of the patients having cronic generalized periodontitis. Results of the conservative treatment with adhesive balm Asepta, gel Hyaludent with metronidazole and clorhexidine and Metrogyl Denta have shown the influence upon immunologic status of the patients.
2010: Stomatologii︠a︡
Carlos Carvajal, Angel Pobo, Emili Díaz, Thiago Lisboa, Mireia Llauradó, Jordi Rello
BACKGROUND AND OBJECTIVE: Mechanical ventilation is used in about one third of patients in intensive cares units (ICU). Ventilator Associated-Pneumonia (VAP) is a frequent infectious complication, affecting approximately 8 to 28% patients. Strategies to prevent the development of VAP are key factors in the management of ICU patients. There have been proposed several strategies to prevent VAP. One of these is oral hygiene with clorhexidine. We evaluated the effect of chlorhexidine on the prevention of VAP...
October 9, 2010: Medicina Clínica
Jordi Rello, Hartmut Lode, Giuseppe Cornaglia, Robert Masterton
BACKGROUND: One recent approach to facilitating guideline implementation involves the use of care bundles. METHODS: This document presents a care bundle package addressing VAP prevention in an attempt to promote guideline-compliant practices. Uniquely, the development of these care bundles used a formalized methodology to assess the supporting data, based on multi-criteria decision analysis. RESULTS: The resulting VAP care bundles for prevention were: non-ventilatory circuit changes unless specifically indicated, alcohol hand hygiene, appropriately educated and trained staff, incorporation of sedation control and weaning protocols into patient care, and oral care with clorhexidine...
May 2010: Intensive Care Medicine
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