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https://www.readbyqxmd.com/read/28622886/five-year-outcomes-of-an-oropharynx-directed-treatment-approach-for-unknown-primary-of-the-head-and-neck
#1
Kenneth Shung Hu, Waleed Fouad Mourad, Mauricio E Gamez, Wilson Lin, Adam Saul Jacobson, Mark Stephen Persky, Mark L Urken, Bruce E Culliney, Zujun Li, Theresa Nguyen Tran, Stimson Pryor Schantz, Juskaran Chadha, Louis Benjamin Harrison
PURPOSE: Squamous cell carcinoma of unknown primary (SCCHNUP) is commonly treated with comprehensive radiation to the laryngopharynx and bilateral necks. In 1998, we established a departmental policy to treat SCCHNUP with radiation directed to the oropharynx and bilateral neck. METHODS: From 1998-2011, 60 patients were treated - N1: 18%, N2: 75% and N3: 7%. 82% underwent neck dissection. 55% received IMRT and 62% underwent concurrent chemoradiotherapy. RESULTS: At median follow-up of 54months, 5 patients failed regionally and 4 emerged with a primary (tongue base, hypopharynx and thoracic esophagus)...
July 2017: Oral Oncology
https://www.readbyqxmd.com/read/28616006/the-burden-of-chronic-pain-after-major-head-and-neck-tumor-therapy
#2
Abdullah Sulieman Terkawi, Siny Tsang, Anwar S Alshehri, Dhaifallah S Mulafikh, Abdulrahman A Alghulikah, Saleh F AlDhahri
INTRODUCTION: Little is known about the burden of chronic pain after major head and neck tumors' therapy. In this study, we aimed to estimate the prevalence of chronic pain, explore the factors associated with the presence of chronic pain, and assess the consequences of chronic pain on the patients' quality of life. METHODOLOGY: This was a cross-sectional survey among patients who had completed their therapy (e.g., surgery, radiotherapy, and chemotherapy) for major head and neck (larynx, nasopharynx, oropharynx, hypopharynx, oral cavity, tongue, and sinuses) tumors after at least 3 months...
May 2017: Saudi Journal of Anaesthesia
https://www.readbyqxmd.com/read/28602410/adjuvant-chemoradiation-after-surgical-resection-in-elderly-patients-with-high-risk-squamous-cell-carcinoma-of-the-head-and-neck-a-national-cancer-database-analysis
#3
Neil M Woody, Matthew C Ward, Shlomo A Koyfman, Chandana A Reddy, Jessica Geiger, Nikhil Joshi, Brian Burkey, Joseph Scharpf, Eric Lamarre, Brandon Prendes, David J Adelstein
PURPOSE: To determine the patterns of adjuvant chemoradiotherapy use in elderly patients treated with definitive surgical resection for squamous cell carcinoma of the head and neck with extracapsular extension (ECE) or positive margins and determine whether an association with overall survival (OS) exists with adjuvant concurrent chemoradiotherapy (CRT). METHODS AND MATERIALS: The National Cancer Database was queried to identify patients with SCC of the oral cavity, oropharynx, larynx, and hypopharynx who were treated with primary definitive surgery and adjuvant radiation therapy between 2004 and 2012...
July 15, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28592347/management-of-the-thyroid-gland-during-laryngectomy
#4
S X Li, M A Polacco, B J Gosselin, L X Harrington, A J Titus, J A Paydarfar
OBJECTIVES: This study aimed to: describe the incidence of thyroid gland involvement in advanced laryngeal cancer, analyse patterns of spread to the thyroid and elucidate predictors of thyroid involvement. METHODS: A retrospective review was performed on patients who underwent laryngectomy from 1991 to 2015 as a primary or salvage treatment for squamous cell carcinoma of the larynx, hypopharynx or base of tongue. The incidence of thyroidectomy during total laryngectomy, type of thyroidectomy, incidence of gland involvement, route of spread, and positive predictors of spread were analysed and reported...
June 8, 2017: Journal of Laryngology and Otology
https://www.readbyqxmd.com/read/28559027/small-cell-carcinoma-of-the-head-and-neck-an-analysis-of-the-national-cancer-database
#5
Kelli B Pointer, Huaising C Ko, Jeffrey V Brower, Matthew E Witek, Randall J Kimple, Ricardo V Lloyd, Paul M Harari, Andrew M Baschnagel
PURPOSE/OBJECTIVE(S): To evaluate treatment trends and overall survival of patients with small cell carcinoma of the head and neck region. MATERIALS/METHODS: Patients from 2004 to 2012 were identified from the National Cancer Database. Patient demographics and overall survival were analyzed. Multivariable analysis was used to identify predictors of survival. RESULTS: Among 347,252 head and neck patients a total of 1042 (0.3%) patients with small cell carcinoma were identified...
June 2017: Oral Oncology
https://www.readbyqxmd.com/read/28559018/outcome-of-recurrent-and-metastatic-head-and-neck-squamous-cell-cancer-patients-after-first-line-platinum-and-cetuximab-therapy
#6
Marco Siano, Gabriele Infante, Carlo Resteghini, Maria Chiara Cau, Salvatore Alfieri, Cristiana Bergamini, Roberta Granata, Rosalba Miceli, Laura Locati, Lisa Licitra, Paolo Bossi
OBJECTIVES: Second-line chemotherapy in recurrent and/or metastatic head and neck cancer (r/mHNSCC) patients showed dismal results with limited tumor response and reduced life expectancy. Outside of clinical trials, data on efficacy of second line treatment after first line anti-EGFR-AB combination therapy are not available. MATERIAL AND METHODS: Data regarding r/mHNSCC consecutive pts treated with cetuximab and platinum from 2009 to 2014 at our center were retrospectively collected...
June 2017: Oral Oncology
https://www.readbyqxmd.com/read/28559014/comparison-cisplatin-with-cisplatin-plus-5fu-in-head-and-neck-cancer-patients-received-postoperative-chemoradiotherapy
#7
Chien-Chih Chen, Jin-Ching Lin, Kuan-Wen Chen
PURPOSE: To compare the treatment outcomes and toxicity of both cisplatin and cisplatin plus 5FU chemotherapy in head and neck cancer patients who have received surgery, in addition to postoperative chemoradiotherapy. MATERIALS AND METHODS: From May 1991 to December 2012, a total of 113 head and neck cancer patients who received surgery, along with postoperative chemoradiotherapy were analyzed. The primary sites were oral cavity (86), oropharynx (17), hypopharynx (4), and larynx (6)...
June 2017: Oral Oncology
https://www.readbyqxmd.com/read/28546958/effect-of-functional-appliances-on-the-airway-dimensions-in-patients-with-skeletal-class-ii-malocclusion-a-systematic-review
#8
Annapurna Kannan, Haritha Pottipalli Sathyanarayana, Sridevi Padmanabhan
OBJECTIVES: The aim of the present systematic review was to assess the effect of functional appliances on the airway dimensions in patients with skeletal Class II malocclusion. MATERIALS AND METHODS: Articles were identified through a literature survey carried out through the following databases: (1) PUBMED, (2) Google Scholar, (3) The Cochrane Library, (4) Embase, (5) Lilac, and (6) Web of Scholars. The systematic review analyzed 12 articles comprising removable functional appliances, 3 articles with fixed functional appliances, and 2 articles having both fixed and removable functional appliances...
April 2017: Journal of Orthodontic Science
https://www.readbyqxmd.com/read/28533859/-a-particular-type-of-cicatricial-pemphigoid-with-unique-iga-deposit
#9
Amina Aounallah, Mariem Jrad, Mehdi Ksiaa, Sana Mokni, Wafa Saidi, Lobna Boussofara, Badreddine Sriha, Mohamed Denguezli, Najet Ghariani, Colandane Belajouza, Rafia Nouira
Cicatricial Pemphigoid is a subepithelial bullous dermatosis which essentially involves the mucous membranes with cicatricial evolution We report the case of a 66-year old patient hospitalized with erosive gingivitis associated with dysphagia, dyspnea and blurred vision. Dermatologic examination showed erosive lesions involving the palate and the pharynx. Ophthalmologic examination showed symblepharons, ectropion and bilateral cataract. Gingival biopsy revealed a necrotic detachment of the buccal epithelium...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28530265/papillary-squamous-cell-carcinoma-of-the-palatine-tonsil-a-rare-cancer-of-the-head-and-neck
#10
A Serra, R Caltabiano, G Scalia, S Palmucci, P Di Mauro, S Cocuzza
Papillary squamous neoplasms of the upper respiratory tract are rare variants of squamous cell carcinomas. They are characterised by an exophytic, papillary growth and generally have favourable prognosis. The tumour has been described in the upper aerodigestive tract. In this context, most common sites of involvement are the larynx and hypopharynx, and rarely the oral cavity and oropharynx. The limited studies and small number of published cases of papillary squamous cell carcinoma of the palatine tonsil led us to make a complete analysis of this tumour by analysing the clinical, histological, radiological, virological and therapeutic aspects that are not always present in the literature...
May 22, 2017: Acta Otorhinolaryngologica Italica
https://www.readbyqxmd.com/read/28513864/the-influence-of-non-rigid-anatomy-and-patient-positioning-on-endoscopy-ct-image-registration-in-the-head-and-neck
#11
W Scott Ingram, Jinzhong Yang, Richard Wendt, Beth M Beadle, Arvind Rao, Xin A Wang, Laurence E Court
PURPOSE: To assess the influence of non-rigid anatomy and differences in patient positioning between CT acquisition and endoscopic examination on endoscopy-CT image registration in the head and neck. METHODS: Radiotherapy planning CTs and 31-35 daily treatment-room CTs were acquired for nineteen patients. Diagnostic CTs were acquired for thirteen of the patients. The surfaces of the airways were segmented on all scans and triangular meshes were created to render virtual endoscopic images with a calibrated pinhole model of an endoscope...
May 17, 2017: Medical Physics
https://www.readbyqxmd.com/read/28489236/histologic-correlation-of-vegf-and-cox-2-expression-with-tumor-size-in-squamous-cell-carcinoma-of-the-larynx-and-hypopharynx
#12
Rodrigo Gonzalez Bonhin, Guilherme Machado de Carvalho, Alexandre Caixeta Guimarães, Vanessa Brito Rocha, Carlos Takahiro Chone, Agrício Nubiato Crespo, Eliane Maria Amstalden
The prognosis and survival of patients with laryngeal and hypopharyngeal squamous cell carcinoma (SCC) are related to the clinical staging. Tumor growth and metastasis are closely related to angiogenesis. Vascular endothelial growth factor (VEGF) and cyclooxygenase 2 (COX-2) are intimately related to the angiogenic process in which the blood supply required for neoplastic evolution is ensured. Considering the contributions of VEGF and COX-2 to the formation, growth, and progression of primary tumors, as well as their metastasis, it has been thought that the expression of these two factors might be related to the size and/or aggressiveness of laryngeal and hypopharyngeal cancer...
April 2017: Ear, Nose, & Throat Journal
https://www.readbyqxmd.com/read/28485362/cancer-statistics-in-kamrup-urban-district-incidence-and-mortality-in-2007-2011
#13
Jagannath Dev Sharma, Amal Chandra Kataki, Debanjana Barman, Arpita Sharma, Manoj Kalita
PURPOSE: The aim of this study was to report cancer statistics in Kamrup Urban District, including incidence and, mortality. INTRODUCTION: In the last five year PBCR-Guwahati witnessed a remarkable growth in cancer incidence cases. The number of new cases of all cancer was increased from 155.3 to 188.5 and 102.7 to 165.3 per 100,000 men and women respectively from the year 2007 to 2011 in KUD. The data from KUD also have shown that for some of the specific types of cancer are highest or some of the highest incidence in rates in the world; particularly cancers of upper aero-digestive tract consist of anatomical sites such as oral cavity, hypopharynx, larynx gallbladder, stomach, lung, prostate and oesophageal cancer...
October 2016: Indian Journal of Cancer
https://www.readbyqxmd.com/read/28483336/prospective-study-of-cetuximab-carboplatin-and-radiation-therapy-for-patients-with-locally-advanced-head-and-neck-squamous-cell-cancer-unfit-for-cisplatin
#14
June Corry, Mathias Bressel, Tsien Fua, Alan Herschtal, Benjamin Solomon, Sandro V Porceddu, Chris Wratten, Danny Rischin
PURPOSE: To report on the outcomes of a novel treatment regimen for patients with locally advanced head and neck squamous cell carcinoma who were fit for curative treatment but not fit for cisplatin. METHODS AND MATERIALS: Single-arm phase 1/2 study of previously untreated patients with biopsy-proven SCC of the oropharynx, larynx, or hypopharynx. The primary endpoint was feasibility of the regimen, defined as the proportion of patients successfully completing treatment...
February 24, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28475848/beyond-positive-margins-and-extracapsular-extension-evaluating-the-utilization-and-clinical-impact-of-postoperative-chemoradiotherapy-in-resected-locally-advanced-head-and-neck-cancer
#15
Daniel M Trifiletti, Andrew Smith, Nandita Mitra, Surbhi Grover, John N Lukens, Roger B Cohen, Paul Read, William M Mendenhall, Alexander Lin, Samuel Swisher-McClure
Purpose To examine recent utilization and survival outcomes associated with use of adjuvant chemoradiotherapy (CRT) for patients with resected locally advanced head and neck cancer (LAHNC) with negative surgical margins (SM negative) and no extracapsular extension (ECE). Materials and Methods We conducted a retrospective observational cohort study using the National Cancer Database evaluating patients diagnosed in 2004 to 2012 with AJCC stage III to IVB squamous cell carcinoma of the oral cavity, oropharynx, hypopharynx, and larynx treated with definitive surgery and adjuvant radiotherapy (RT) or CRT...
May 10, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28474378/transoral-laser-microsurgery-for-treatment-for-hypopharyngeal-cancer-in-211-patients
#16
Bernhard G Weiss, Friedrich Ihler, Hendrik A Wolff, Simon Schneider, Martin Canis, Wolfgang Steiner, Christian Welz
BACKGROUND: The oncologic and functional outcome of transoral laser microsurgery (TLM) for primary treatment of hypopharyngeal cancer was examined in a multimodal treatment concept. METHODS: Two hundred eleven patients with squamous cell carcinoma (SCC) of the hypopharynx (pT1-4a, pN0-2, M0) were treated by TLM +/- neck dissection (88%) +/- (chemo)radiotherapy ([C]RT; 51%). The majority of cases were advanced stages III and IVa (85%). RESULTS: The 5-year Kaplan-Meier estimates for local control after TLM were pT category-related 88...
May 5, 2017: Head & Neck
https://www.readbyqxmd.com/read/28473272/novel-application-of-a-rigid-curved-larygno-pharyngoscope-for-examination-and-treatment-of-hypopharyngeal-lesions
#17
Kenichi Watanabe, Daisuke Yamauchi, Yoshitaka Takanashi, Hiroshi Hidaka, Yukio Katori
In endoscopic laryngo-pharyngeal surgery (ELPS), a rigid curved laryngo-pharyngoscope, which was invented by Dr. Sato et al., is necessary to obtain excellent surgical view of both hypopharynx and even the entrance of the esophagus. We have used this instrument for the examination and treatment of several diseases other than cancer located in the hypopharynx, such as difficult-to-find buried fish bones, retropharyngeal abscess, and congenital pyriform sinus fistula. In the result, we could acquire better view of hypopharynx and completed the intended procedure safely, especially for uncovering difficult-to-find fish bone buried in the mucosa...
May 1, 2017: Auris, Nasus, Larynx
https://www.readbyqxmd.com/read/28472351/the-benefits-and-limitations-of-targeted-training-in-flexible-transnasal-laryngoscopy-diagnosis
#18
Kimberly A Russell, Christopher D Brook, Michael P Platt, Gregory A Grillone, Avner Aliphas, J Pieter Noordzij
Importance: Targeted laryngoscopy training can be used successfully in de novo learners. Objective: To determine the value of targeted laryngoscopy education in interns. Design, Setting, and Participants: This prospective study of fiberoptic laryngoscopy interpretations enrolled 13 participants in an academic hospital setting from August 1 to December 31, 2015. Participants included 10 postgraduate year 1 emergency and otolaryngology interns and 3 board-certified otolaryngology attending physicians...
May 4, 2017: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/28444831/analysis-of-modulation-factor-to-shorten-the-delivery-time-in-helical-tomotherapy
#19
Hidetoshi Shimizu, Koji Sasaki, Hiroyuki Tachibana, Natsuo Tomita, Chiyoko Makita, Kuniyasu Nakashima, Kazushi Yokoi, Takashi Kubota, Manabu Yoshimoto, Tohru Iwata, Takeshi Kodaira
A low modulation factor (MF) maintaining a good dose distribution contributes to the shortening of the delivery time and efficiency of the treatment plan in helical tomotherapy. The purpose of this study was to reduce the delivery time using initial values and the upper limit values of MF. First, patients with head and neck cancer (293 cases) or prostate cancer (181 cases) treated between June 2011 and July 2015 were included in the analysis of MF values. The initial MF value (MFinitial ) was defined as the average MFactual value, and the upper limit of the MF value (MFUL ) was defined according the following equation: MFUL = 2 × standard deviation of MFactual value + the average MFactual Next, a treatment plan was designed for patients with head and neck cancer (62 cases) and prostate cancer (13 cases) treated between December 2015 and June 2016...
April 26, 2017: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28444429/hypopharyngeal-and-upper-esophageal-ulceration-after-cervical-spine-radiotherapy-concurrent-with-crizotinib
#20
Marcus H Zimmermann, Gabriele Beckmann, Pius Jung, Michael Flentje
Herein, the authors describe the case of a 31-year-old female patient with primary metastatic adenocarcinoma of the lung referred for radiation therapy of newly diagnosed intramedullary spinal cord metastasis at C4/5 and an adjacent osteolytic lesion. Radiotherapy of the cervical spine level C3 to C5, including the whole vertebra, was performed with 30 Gy in 10 fractions. The patient's systemic therapy with crizotinib 250 mg twice daily was continued. After 8 fractions of radiation the patient developed increasing dysphagia...
April 25, 2017: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
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