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https://www.readbyqxmd.com/read/27913720/presentation-and-management-of-giant-fibrovascular-polyps-of-the-hypopharynx-and-esophagus
#1
Julina Ongkasuwan, C Lane Anzalone, Esperanza Salazar, Donald T Donovan
OBJECTIVE: Fibrovascular polyps of the hypopharynx and esophagus are rare, with few case reports in the literature. In this article, we present our institutional experience with a focus on airway and surgical management. STUDY DESIGN: Case series. SETTING: Tertiary academic institution. METHODS: A retrospective review was conducted of 4 patients that presented to a tertiary medical center with fibrovascular polyps between 1990 and 2012...
January 2017: Annals of Otology, Rhinology, and Laryngology
https://www.readbyqxmd.com/read/27913065/hpv-status-cancer-stem-cell-marker-expression-hypoxia-gene-signatures-and-tumour-volume-identify-good-prognosis-subgroups-in-patients-with-hnscc-after-primary-radiochemotherapy-a-multicentre-retrospective-study-of-the-german-cancer-consortium-radiation-oncology
#2
Annett Linge, Fabian Lohaus, Steffen Löck, Alexander Nowak, Volker Gudziol, Chiara Valentini, Cläre von Neubeck, Martin Jütz, Inge Tinhofer, Volker Budach, Ali Sak, Martin Stuschke, Panagiotis Balermpas, Claus Rödel, Anca-Ligia Grosu, Amir Abdollahi, Jürgen Debus, Ute Ganswindt, Claus Belka, Steffi Pigorsch, Stephanie E Combs, David Mönnich, Daniel Zips, Frank Buchholz, Daniela E Aust, Gustavo B Baretton, Howard D Thames, Anna Dubrovska, Jan Alsner, Jens Overgaard, Mechthild Krause, Michael Baumann
OBJECTIVE: To investigate the impact of the tumour volume, HPV status, cancer stem cell (CSC) marker expression and hypoxia gene signatures, as potential markers of radiobiological mechanisms of radioresistance, in a contemporary cohort of patients with locally advanced head and neck squamous cell carcinoma (HNSCC), who received primary radiochemotherapy (RCTx). MATERIALS AND METHODS: For 158 patients with locally advanced HNSCC of the oral cavity, oropharynx or hypopharynx who were treated at six DKTK partner sites, the impact of tumour volume, HPV DNA, p16 overexpression, p53 expression, CSC marker expression and hypoxia-associated gene signatures on outcome of primary RCTx was retrospectively analyzed...
November 29, 2016: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/27893557/changes-in-upper-airway-volume-following-orthognathic-surgery
#3
Lillian Marcussen, Kasper Stokbro, Esben Aagaard, Peter Torkov, Torben Thygesen
Reduced volume of the internal skeletal dimensions of the face is 1 of the main causes of obstructive sleep apnea, and attention to patients' airways is necessary when planning orthognathic treatment. This study aims to describe changes in upper airway volume following virtually planned orthognathic surgery.A retrospective pilot study was designed with 30 randomly selected patients (10 men and 20 women, aged 23.1 ± 6.8 years, molar-relations: 15 neutral, 8 distal, and 7 mesial). Cone-beam computed tomography scans were performed before surgery and 1 week following surgery...
November 23, 2016: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/27875508/extensive-oral-mucormycosis-in-a-transplanted-patient
#4
Bernar Monteiro Benites, Felipe Paiva Fonseca, Claudia Joffily Parahyba, Sergio Samir Arap, Yana Augusta Novis, Eduardo Rodrigues Fregnani
Mucormycosis is an invasive fungal disease caused by fungi from the Mucorales order that are found in the soil and decaying organic debris. Mucormycosis has been reported to be the third most common fungal disease in stem cell transplanted patients. The fungi have a tendency for vascular invasion, resulting in thrombi development, which decreases blood supply and leads to extensive tissue necrosis. Here, the authors present a patient of mucormycosis affecting the soft palate, oropharynx, and hypopharynx in a type II diabetic male patient who underwent allogeneic stem cell transplantation, and the authors further review the literature on oral mucormycosis for the last 10 years...
November 21, 2016: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/27869097/the-impact-of-radiation-treatment-time-on-survival-in-patients-with-head-and-neck-cancer
#5
Talha Shaikh, Elizabeth A Handorf, Colin T Murphy, Ranee Mehra, John A Ridge, Thomas J Galloway
PURPOSE: To assess the impact of radiation treatment time (RTT) in head and neck cancers on overall survival (OS) in the era of chemoradiation. METHODS AND MATERIALS: Patients with diagnoses of tongue, hypopharynx, larynx, oropharynx, or tonsil cancer were identified by use of the National Cancer Database. RTT was defined as date of first radiation treatment to date of last radiation treatment. In the definitive setting, prolonged RTT was defined as >56 days, accelerated RTT was defined as <47 days, and standard RTT was defined as 47 to 56 days...
December 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27859177/past-sexual-behaviors-and-risks-of-oropharyngeal-squamous-cell-carcinoma-a-case-case-comparison
#6
Christoph Schnelle, David C Whiteman, Sandro V Porceddu, Benedict J Panizza, And Annika Antonsson
The incidence of oropharyngeal squamous cell carcinomas (SCCs) is increasing and is believed to reflect changing sexual practices in recent decades. For this case-case comparative study, we collected medical and life-style information and data on sexual behavior from 478 patients treated at the head and neck clinic of a tertiary hospital in Brisbane, Australia. Patients were grouped as (i) oropharyngeal SCC (n = 96), (ii) oral cavity, larynx and hypopharynx SCC ("other HNSCCs," n = 96), (iii) other SCCs (n = 141), and (iv) other diagnoses (n = 145)...
November 16, 2016: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/27844223/untreated-head-and-neck-cancer-in-korea-a-national-cohort-study
#7
Hyo Geun Choi, Bumjung Park, Soon-Hyun Ahn
Few studies have analyzed the survival of patients with untreated head and neck cancer. The objective of this study is to assess the survival rates of untreated head and neck cancer patients and to determine why the patients were not treated. Using data from a national patient sample cohort (1,025,340 cases) from the Korean Health Insurance Review and Assessment Service, 605 patients with diagnoses of head and neck cancer (lip and oral cavity, oropharynx, hypopharynx, and laryngeal cancer) between 2003 and 2013 were evaluated...
November 14, 2016: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/27825651/sequential-four-drug-chemotherapy-and-intensity-modulated-radiotherapy-for-larynx-preservation-in-resectable-advanced-larynx-and-hypopharynx-cancer-a-pilot-study
#8
Xuan Su, Caiyun He, Tao Tang, Weichao Chen, Zhaoqu Li, Yong Chen, Ankui Yang
OBJECTIVE: The value of additional use of cetuximab with the classical cisplatin, docetaxel and 5-fluorouracil regimen in larynx preservation remains unknown. This study was designed to resolve this issue and appraise its toxicity. MATERIALS AND METHODS: Thirteen untreated patients with stage III-IV larynx or hypopharynx squamous cell carcinoma were recruited and received two cycles of C+TPF regimen (cetuximab plus docetaxel, cisplatinand and 5-fluorouracil), followed by one more cycle of C+TPF and intensity-modulated radiotherapy (70Gy)...
September 28, 2016: American Journal of Otolaryngology
https://www.readbyqxmd.com/read/27812016/circulating-vitamin-d-in-relation-to-cancer-incidence-and-survival-of-the-head-and-neck-and-oesophagus-in-the-epic-cohort
#9
Anouar Fanidi, David C Muller, Øivind Midttun, Per Magne Ueland, Stein Emil Vollset, Caroline Relton, Paolo Vineis, Elisabete Weiderpass, Guri Skeie, Magritt Brustad, Domenico Palli, Rosario Tumino, Sara Grioni, Carlotta Sacerdote, H B As Bueno-de-Mesquita, Petra H Peeters, Marie-Christine Boutron-Ruault, Marina Kvaskoff, Claire Cadeau, José María Huerta, Maria-José Sánchez, Antonio Agudo, Cristina Lasheras, J Ramón Quirós, Saioa Chamosa, Elio Riboli, Ruth C Travis, Heather Ward, Neil Murphy, Kay-Tee Khaw, Antonia Trichopoulou, Pagona Lagiou, Eleni-Maria Papatesta, Heiner Boeing, Tilman Kuehn, Verena Katzke, Annika Steffen, Anders Johansson, Paul Brennan, Mattias Johansson
Experimental and epidemiological data suggest that vitamin D play a role in pathogenesis and progression of cancer, but prospective data on head and neck cancer (HNC) and oesophagus cancer are limited. The European Prospective Investigation into Cancer and Nutrition (EPIC) study recruited 385,747 participants with blood samples between 1992 and 2000. This analysis includes 497 case-control pairs of the head and neck and oesophagus, as well as 443 additional controls. Circulating 25(OH)D3 were measured in pre-diagnostic samples and evaluated in relation to HNC and oesophagus cancer risk and post-diagnosis all-cause mortality...
November 4, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27802182/dynamic-contrast-enhanced-magnetic-resonance-imaging-for-pretreatment-prediction-of-early-chemo-radiotherapy-response-in-larynx-and-hypopharynx-carcinoma
#10
Wei Guo, Dehong Luo, Xinyi Chen, Meng Lin, Lin Li, Yanfeng Zhao, Liang Yang, Lei Hu, Xinming Zhao, Chunwu Zhou
PURPOSE: This study is to investigate the use of dynamic contrast-enhanced magnetic resonance imaging in predicting early response to CRT (chemo-radiotherapy) in patients with larynx and hypopharynx carcinoma from primary tumors. METHOD: Sixty-two patients with larynx and hypopharynx carcinoma underwent two DCE-MRI studies: a baseline exam before any treatmentanda post-treatment exam 3 weeks after CRT. At the end of treatment, patients were classified as responders, or non-responders according to the Response Evaluation Criteria in Solid Tumors criteria (RECIST)...
October 27, 2016: Oncotarget
https://www.readbyqxmd.com/read/27799228/synchronous-perforations-of-the-oesophagus-and-stomach-by-air-insufflation-an-uncommon-complication-of-endoscopic-dilation
#11
Arthur M Fung, Fion S Chan, Ian Y Wong, Simon Law
A 72-year-old woman had a history of carcinoma of the hypopharynx treated by total laryngectomy, circumferential pharyngectomy and free jejunal graft. Endoscopic dilation of the pharyngojejunal anastomotic stricture resulted in synchronous perforations of the oesophagus and stomach. We postulate that the perforations were caused by high intraoesophageal and intragastric pressure resulted from air insufflation during the procedure; in a situation simulating closed-loop obstruction, because of proximal obstruction by the endoscope at the stricture site and distal obstruction by pylorospasm...
October 31, 2016: BMJ Case Reports
https://www.readbyqxmd.com/read/27796047/does-drug-induced-sleep-endoscopy-predict-surgical-success-in-transoral-robotic-multilevel-surgery-in-obstructive-sleep-apnea
#12
Taha S Meraj, Daniel G Muenz, Tiffany A Glazer, Rebecca S Harvey, Matthew E Spector, Paul T Hoff
OBJECTIVES/HYPOTHESIS: The aim of this study was to determine if drug-induced sleep endoscopy (DISE) was predictive of success for patients undergoing transoral robotic surgery (TORS) and multilevel procedures for sleep apnea. STUDY DESIGN: Retrospective case series of patients who underwent TORS surgery for sleep apnea METHODS: Before and after polysomnograms were analyzed to assess improvement, success, and cure. Improvement was defined as any decrease in apnea-hypopnea index (AHI), success as an AHI <20 with a decrease >50%, and cure as an AHI <5...
October 31, 2016: Laryngoscope
https://www.readbyqxmd.com/read/27795863/lipoma-of-piriform-sinus-a-case-report-and-review-of-the-literature
#13
Gilberto Acquaviva, Theodoros Varakliotis, Stefano Badia, Francesco Casorati, Alberto Eibenstein, Gianluca Bellocchi
The lipomas of oropharynx, hypopharynx, and larynx are so rare that up to now approximately there have been 100 cases reported. The lipomas are slow-growing lesions that are capable of reaching considerable dimensions and are often detected at a late stage. The symptoms can vary both in dimension and in location, semiobstructing the aerodigestive tract or exerting compression on adjacent structure. In this case, the lesion, which originated from the piriform sinus, was removed endoscopically urgently due to obvious signs of tissue suffering caused by stretching of the pedicle as a result of displacement of the mass...
2016: Case Reports in Otolaryngology
https://www.readbyqxmd.com/read/27792825/features-of-oral-pharyngeal-and-laryngeal-lesions-in-bullous-pemphigoid
#14
Masafumi Ohki, Shigeru Kikuchi, Atsushi Ohata, Yuka Baba, Junichi Ishikawa, Hirohito Sugimoto
Bullous pemphigoid is an autoimmune bullous disease characterized by skin lesions, with or without oral lesions. The occurrence of pharyngolaryngeal lesions is very rare in affected patients. We conducted a study to investigate the characteristics of oral and pharyngolaryngeal lesions in bullous pemphigoid. Our study population was made up of 6 consecutively presenting outpatients-2 men and 4 women, aged 40 to 83 years (mean: 68.2)-who had been referred to our department over an 11-year period. Presenting symptoms included sore throat in all 6 patients and oral pain in 3...
October 2016: Ear, Nose, & Throat Journal
https://www.readbyqxmd.com/read/27792258/flex-robotic-system-in-transoral-robotic-surgery-the-first-40-patients
#15
Stefan Mattheis, Pia Hasskamp, Laura Holtmann, Christina Schäfer, Urban Geisthoff, Nina Dominas, Stephan Lang
BACKGROUND: The Flex Robotic System is a new robotic device specifically developed for transoral robotic surgery (TORS). METHODS: We performed a prospective clinical study, assessing the safety and efficacy of the Medrobotics Flex Robotic System. A total of 40 patients required a surgical procedure for benign lesions (n = 30) or T1 and T2 carcinomas (n = 10). Access and visualization of different anatomic subsites were individually graded by the surgeon. Setup times, access and visualization times, surgical results, as well as adverse events were documented intraoperatively...
October 28, 2016: Head & Neck
https://www.readbyqxmd.com/read/27789026/differentiating-recurrent-tumours-from-post-treatment-changes-in-head-and-neck-cancers-does-diffusion-weighted-mri-solve-the-eternal-dilemma
#16
S Vaid, A Chandorkar, A Atre, D Shah, N Vaid
AIM: To evaluate the utility of diffusion-weighted imaging (DWI) in differentiating post-treatment changes from tumour recurrence in head and neck cancers and to establish a threshold apparent diffusion coefficient (ADC) value to differentiate the two conditions. MATERIALS AND METHODS: This was a prospective study of 80 treated head and neck cancer patients. The patient cohort consisted of a wide spectrum of head and neck sites, including the oral cavity, oropharynx, larynx, hypopharynx, paranasal sinuses, orbits, salivary glands, and infra-temporal fossa...
October 24, 2016: Clinical Radiology
https://www.readbyqxmd.com/read/27783427/a-european-multicenter-study-evaluating-the-flex-robotic-system-in-transoral-robotic-surgery
#17
Stephan Lang, Stefan Mattheis, Pia Hasskamp, Georges Lawson, Christian Güldner, Magis Mandapathil, Patrick Schuler, Thomas Hoffmann, Marc Scheithauer, Marc Remacle
OBJECTIVES/HYPOTHESIS: To evaluate the application of the Flex Robotic System in transoral robotic surgery (TORS). STUDY DESIGN: Multicenter, prospective, open-label, single-armed clinical study. METHODS: A prospective clinical follow-up multicenter study was performed from July 2014 to October 2015 assessing the safety and efficacy of the Medrobotics Flex Robotic System for access and visualization of the oropharynx, hypopharynx, and larynx as well as for resection of benign and malignant lesions...
October 26, 2016: Laryngoscope
https://www.readbyqxmd.com/read/27762071/immunohistochemical-studies-and-fluorodeoxyglucose-uptake-on-positron-emission-tomography-in-pharyngeal-cancer-for-predicting-radiotherapy-based-treatment-outcomes
#18
Y-C Lin, R-Y Chen, S-W Chen, T-C Hsieh, K-Y Yen, J-A Liang, S-N Yang, Y-C Wang, Y-H Chen, N-H Chow, C-H Kao
OBJECTIVES: This study correlated immunohistochemical studies with fluorodeoxyglucose (FDG) uptake on positron emission tomography-computed tomography (PET-CT) and identified prognostic factors for radiotherapy (RT)-based treatment outcomes in patients with squamous cell carcinoma of the oropharynx and hypopharynx. METHODS: Genomic data from pre-treatment biopsy specimens (Glut1, CAIX, VEGF, HIF-1α, EGFR, Ki-67, Bcl-2, CLAUDIN-4, YAP-1, c-Met and p16) of 76 patients were analysed using tissue microarrays...
October 20, 2016: Clinical Otolaryngology
https://www.readbyqxmd.com/read/27761051/left-molar-approach-using-adult-c-mac-videolaryngoscope-for-airway-management-of-a-child-with-nasopharyngeal-carcinoma-extending-to-hypopharynx
#19
Anju Gupta, Nishkarsh Gupta
No abstract text is available yet for this article.
October 2016: Indian Journal of Anaesthesia
https://www.readbyqxmd.com/read/27751621/prognostic-significance-of-p16-in-squamous-cell-carcinoma-of-the-larynx-and-hypopharynx
#20
Jessica Meshman, Pin-Chieh Wang, Robert Chin, Maie St John, Elliot Abemayor, Sunita Bhuta, Allen M Chen
PURPOSE: To evaluate the prognostic significance of p16 expression among patients with squamous cell carcinoma of the larynx (LSCC) and hypopharynx (HSCC). METHODS: The medical records of all patients with locally advanced, non-metastatic LSCC/HSCC were reviewed. p16(INK4A) (p16) protein expression was evaluated on pathological specimens by immunohistochemistry (IHC), and the Kaplan-Meier method was used to estimate overall survival (OS) and locoregional control (LRC)...
September 28, 2016: American Journal of Otolaryngology
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