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https://www.readbyqxmd.com/read/29452770/single-arm-phase-2-trial-of-elective-nodal-dose-reduction-for-patients-with-locoregionally-advanced-squamous-cell-carcinoma-of-the-head-and-neck
#1
Patrick D Maguire, Charles R Neal, Stuart M Hardy, Andrew M Schreiber
PURPOSE: To evaluate a novel chemoradiation therapy (CRT) regimen for patients with squamous cell carcinoma of the head and neck (SCCHN) incorporating a lower intensity modulated radiation therapy dose to electively treated neck lymph nodes than is currently standard. METHODS AND MATERIALS: Eligible patients had locally advanced SCCHN of the oral cavity, oropharynx, larynx, or hypopharynx. The 7-week CRT course consisted of weekly cisplatin at 35 mg/m 2 concurrently with sequential-boost intensity modulated radiation therapy: 36 Gy to high- and low-risk planning target volumes followed by a sequential boost to the high-risk planning target volume to 70 Gy...
December 28, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29447885/pediatric-head-and-neck-squamous-cell-carcinoma-patient-demographics-treatment-trends-and-outcomes
#2
Ankit Modh, Omar H Gayar, Mohamed A Elshaikh, Arnold C Paulino, Farzan Siddiqui
OBJECTIVES: To examine patient demographics, temporal and treatment trends, and survival outcomes of pediatric non-nasopharyngeal head and neck squamous cell carcinomas using the National Cancer Database. METHODS: The National Cancer Database was queried for pediatric patients (age 0-19 years) diagnosed with squamous cell carcinoma of the head and neck (including oral cavity, oropharynx, nasal cavity, larynx, hypopharynx, and salivary glands) from 2004 to 2013. RESULTS: Of 159 patients identified, the majority had oral cavity SCC (55%)...
March 2018: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/29436282/patient-choice-of-nonsurgical-treatment-contributes-to-disparities-in-head-and-neck-squamous-cell-carcinoma
#3
Harman S Parhar, Donald W Anderson, Arif S Janjua, J Scott Durham, Eitan Prisman
Objectives There are well-established outcome disparities among different demographic groups with head and neck squamous cell carcinoma (HNSCC). We aimed to investigate the potential contribution of patient choice of nonsurgical treatment to these disparities by estimating the rate of this phenomenon, identifying its predictors, and estimating the effect on cancer-specific survival. Study Design Retrospective nationwide analysis. Settings Surveillance, Epidemiology, and End Results Database (2004-2014). Subjects and Methods Patients with HNSCC, who were recommended for primary surgery, were included...
February 1, 2018: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/29429177/-planned-neck-dissection-in-the-treatment-of-locally-advanced-head-and-neck-squamous-cell-carcinoma
#4
L Jiang, J L Lou, K J Wang, M Y Fang, Z F Fu
Objective: To investigate the value of planned neck dissection combined with induction chemotherapy and concurrent chemoradiotherapy in regional control and the outcome of locally advanced head and neck squamous cell carcinoma. Methods: A prospective randomized controlled study totally enrolled sixty-four patients of head and neck squamous cell carcinomas(include oropharynx, hypopharynx, and larynx) in stages Ⅳa-Ⅳb with lymph node metastase was were N2-N3. All patients firstly received 2-3 cycles of induction chemotherapy(ICT), then divided into two groups randomly, according to the efficacy of ICT...
February 7, 2018: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
https://www.readbyqxmd.com/read/29423749/swallowing-evaluation-after-surgery-for-obstructive-sleep-apnea-syndrome-uvulopalatopharyngoplasty-vs-expansion-pharyngoplasty
#5
Anne M B Corradi, Liciane P Valarelli, Thaís H Grechi, Alan L Eckeli, Davi C Aragon, Daniel S Küpper, Leila A Almeida, Heidi H Sander, Luciana V V Trawitzki, Fabiana C P Valera
PURPOSE: To evaluate the effect of pharyngeal surgery on swallowing pattern in patients with obstructive sleep apnea syndrome (OSAS), and to compare two surgical techniques: uvulopalatopharyngoplasty (UPPP) and expansion pharyngoplasty (EP), through videofluoroscopy. METHODS: Longitudinal prospective cohort, in a tertiary referral center. 17 adult patients were enrolled this study, divided into two groups: patients who underwent UPPP (n = 10) or EP (n = 7)...
February 8, 2018: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/29415020/the-evolution-of-the-epidemiological-landscape-of-head-and-neck-cancer-in-italy-is-there-evidence-for-an-increase-in-the-incidence-of-potentially-hpv-related-carcinomas
#6
Paolo Boscolo-Rizzo, Manuel Zorzi, Annarosa Del Mistro, Maria Cristina Da Mosto, Giancarlo Tirelli, Carlotta Buzzoni, Massimo Rugge, Jerry Polesel, Stefano Guzzinati
The current study aimed to investigate the incidence and survival patterns of HNSCCs arising from different anatomic sites, potentially related (the oropharynx) or unrelated (the oral cavity, the larynx/hypopharynx) to HPV, to provide clues on possible growing impact of HPV in the epidemiology of HNSCC in Italy. Epidemiological data were retrieved from ten long-term Cancer Registries covering a population of 7.8 million inhabitants. Trends were described by means of the estimated annual percent change (APC) stratified by age and gender, and compared between HPV-related and HPV-unrelated anatomical sites...
2018: PloS One
https://www.readbyqxmd.com/read/29412371/trend-of-oral-and-pharyngeal-cancer-mortality-in-brazil-in-the-period-of-2002-to-2013
#7
Lillia Magali Estrada Perea, Marco Aurélio Peres, Antonio Fernando Boing, José Leopoldo Ferreira Antunes
OBJECTIVE: To analyze the trend of oral and pharyngeal cancer mortality rates in the period of 2002 to 2013 in Brazil according to sex, anatomical site, and macroregion of the country. METHODS: The mortality data were obtained from the Mortality Information System and the population data were obtained from the Brazilian Institute of Geography and Statistics. The trend of the rates standardized by sex and age was calculated using the Prais-Winsten estimation, and we obtained the annual percentage change and the respective 95% confidence intervals, analyzed according to sex, macroregion, and anatomical site...
February 5, 2018: Revista de Saúde Pública
https://www.readbyqxmd.com/read/29408977/phase-ii-trial-of-combination-treatment-with-paclitaxel-carboplatin-and-cetuximab-pce-as-first-line-treatment-in-patients-with-recurrent-and-or-metastatic-squamous-cell-carcinoma-of-the-head-and-neck-cspor-hn02
#8
M Tahara, N Kiyota, T Yokota, Y Hasegawa, K Muro, S Takahashi, T Onoe, A Homma, J Taguchi, M Suzuki, K Minato, K Yane, S Ueda, H Hara, K Saijo, T Yamanaka
Background: The standard of care for first-line treatment of recurrent and/or metastatic squamous cell carcinoma of the head and neck (R/M SCCHN) is combination treatment with platinum, 5-FU and cetuximab (PFE). However, this regimen requires hospitalization to ensure proper hydration and continuous infusion of 5-FU, and causes severe nausea and anorexia. We evaluated the efficacy and safety of paclitaxel, carboplatin and cetuximab (PCE) as first-line treatment in patients with R/M SCCHN...
February 2, 2018: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/29405297/the-influence-of-smoking-age-and-stage-at-diagnosis-on-the-survival-after-larynx-hypopharynx-and-oral-cavity-cancers-in-europe-the-arcage-study
#9
Renata Abrahão, Devasena Anantharaman, Valérie Gaborieau, Behnoush Abedi-Ardekani, Pagona Lagiou, Areti Lagiou, Wolfgang Ahrens, Ivana Holcatova, Jaroslav Betka, Franco Merletti, Lorenzo Richiardi, Kristina Kjaerheim, Diego Serraino, Jerry Polesel, Lorenzo Simonato, Laia Alemany, Antonio Agudo Trigueros, Tatiana V Macfarlane, Gary J Macfarlane, Ariana Znaor, Max Robinson, Cristina Canova, David I Conway, Sylvia Wright, Claire M Healy, Mary Toner, Gabriella Cadoni, Stefania Boccia, Tarik Gheit, Massimo Tommasino, Ghislaine Scelo, Paul Brennan
Head and neck cancer (HNC) is a preventable malignancy that continues to cause substantial morbidity and mortality worldwide. Using data from the ARCAGE and Rome studies, we investigated the main predictors of survival after larynx, hypopharynx and oral cavity (OC) cancers. We used the Kaplan-Meier method to estimate overall survival, and Cox proportional models to examine the relationship between survival and sociodemographic and clinical characteristics. 604 larynx, 146 hypopharynx and 460 OC cancer cases were included in this study...
February 6, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29404898/induction-chemotherapy-with-the-extreme-regimen-in-frail-patients-with-locally-advanced-head-and-neck-squamous-cell-carcinoma
#10
Valérie Cochin, Erwan de Mones, Laurence Digue, Muriel Garcia-Ramirez, Charles Dupin, Claire Majoufre, Philipe Fernandez, Amaury Daste
BACKGROUND: Induction chemotherapy (IC) with TPF (docetaxel, cisplatin, 5FU) for locally advanced head and neck squamous cell carcinoma (LAHNSCC) is limited to fit patients. OBJECTIVE: We conducted a retrospective cohort study to assess the use of the EXTREME regimen (platinum-based therapy, 5FU, cetuximab) as IC in frail patients with LAHNSCC. PATIENTS AND METHODS: Retrospective analysis of all consecutive patients with unresectable LAHNSCC treated with the EXTREME regimen, with or without 5FU as IC, from two French centers from 2008 to 2015...
February 5, 2018: Targeted Oncology
https://www.readbyqxmd.com/read/29402786/rigid-triple-endoscopy-improves-clinical-staging-of-primary-head-and-neck-cancer
#11
Shachi J Sharma, Jens J Linke, Tobias Kroll, Nora Wuerdemann, Jens P Klussmann, Orlando Guntinas-Lichius, Claus Wittekindt
BACKGROUND: Correct pre-therapeutic staging of the first primary carcinoma (FPC) and detection of simultaneous second primary carcinomas (SSPCs) decisively influence therapy and prognosis of head and neck squamous cell carcinomas (HNSCC). The aim of this study was to determine the benefit of pre-therapeutic triple endoscopy for detection of SSPC and pre-therapeutic T category. METHODS: A cohort of 234 HNSCC patients with completed triple endoscopy was reviewed, focusing on pre-therapeutic T category and SSPC...
2018: Oncology Research and Treatment
https://www.readbyqxmd.com/read/29394795/-a-case-report-on-successful-larynx-preserving-surgery-for-a-cervical-esophageal-cancer-that-invaded-the-hypopharynx
#12
Osamu Shiraishi, Hiroaki Kato, Mitsuru Iwama, Yoko Hiraki, Atsushi Yasuda, Masayuki Shinkai, Motohiro Imano, Yutaka Kimura, Haruhiko Imamoto, Takushi Yasuda
The patient was a 58-year-old man suffering from dysphagia. He was diagnosed with T3 cervicalesophagealcancer that invaded the posterior hypopharyngealwal lwith lymph node metastasis. The patient received neoadjuvant chemoradiotherapy (30 Gy with CDDP/5-FU), followed by larynx-preserving surgery(LPS)for cervicalesophagealcancer. Two techniques for successfulLPS consist of the dissections of cricopharyngealmuscl e and the inferior pharyngealsphincter, and the complete division of the bilateral infrahyoid muscles attached to the sternum(CDBIMS)...
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29383312/pattern-of-gustatory-impairment-and-its-recovery-after-head-and-neck-irradiation
#13
Preety Negi, Pamela-Alice Kingsley, Maria Thomas, Jaineet Sachdeva, Himanshu Srivastava, Babusha Kalra
Introduction: The majority of patients receiving concurrent chemoradiotherapy frequently complain of changes in their taste perception, and other distressing symptoms affecting their quality of life. This study was undertaken to determine the pattern of gustatory impairment and its recovery in irradiated head and neck cancer patients in India. Materials and Methods: Thirty patients undergoing radical head and neck irradiation were enrolled and assessed for the four basic taste quality (sweet, salt, sour and bitter) by a forced three-choice stimulus drop technique measuring their taste recognition thresholds at baseline, weekly during radiation therapy (RT) and every month for 6 months following completion of RT...
November 2017: Iranian Journal of Otorhinolaryngology
https://www.readbyqxmd.com/read/29371888/identification-of-genomic-copy-number-variations-associated-with-specific-clinical-features-of-head-and-neck-cancer
#14
Boris Zagradišnik, Danijela Krgović, Špela Stangler Herodež, Andreja Zagorac, Bogdan Ćižmarević, Nadja Kokalj Vokač
Background: Copy number variations (CNSs) of large genomic regions are an important mechanism implicated in the development of head and neck cancer, however, for most changes their exact role is not well understood. The aim of this study was to find possible associations between gains/losses of genomic regions and clinically distinct subgroups of head and neck cancer patients. Results: Array comparative genomic hybridization (aCGH) analysis was performed on DNA samples in 64 patients with cancer in oral cavity, oropharynx or hypopharynx...
2018: Molecular Cytogenetics
https://www.readbyqxmd.com/read/29368599/effectiveness-of-nasal-highflow-in-hypercapnic-copd-patients-is-flow-and-leakage-dependent
#15
Jens Bräunlich, Friederike Mauersberger, Hubert Wirtz
BACKGROUND: Nasal Highflow (NHF) delivers a humidified and heated airflow via nasal prongs. Current data provide evidence for efficacy of NHF in patients with hypoxemic respiratory failure. Preliminary data suggest that NHF may decrease hypercapnia in hypercapnic respiratory failure. The aim of this study was to evaluate the mechanism of NHF mediated PCO2 reduction in patients with chronic obstructive pulmonary disease (COPD). METHODS: In 36 hypercapnic COPD patients (PCO2 > 45 mmHg), hypercapnia was evaluated by capillary gas sampling 1 h after NHF breathing under four conditions A to D with different flow rates and different degrees of leakage (A = 20 L/min, low leakage, two prongs, both inside; B = 40 L/min, low leakage, two prongs, both inside; C = 40 L/min, high leakage, two prongs, one outside and open; D = 40 L/min, high leakage, two prongs, one outside and closed)...
January 24, 2018: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/29365380/-application-of-endoscope-assisted-curved-laryngoscopy-technique-in-transoral-laryngopharyngeal-minimally-invasive-surgery
#16
L J Li, C Du, L Wang, Y Yan, J Zeng, C Y Xu, S L Sun
Objective: To explore the possibility of endoscope assisted curved laryngoscopy technique applied in transoral laryngopharyngeal minimally invasive surgery and evaluate the advantages of this technique. Methods: Eight patients with huge benign lesions in larynx and pharynx undergoing transoral microsurgery at Peking University Third Hospital between February 2016 and February 2017 were enrolled in this study.The diagnosis included cyst at the base of tongue in two patients, cysts in the epiglottis in two patients, hemangioma in two patients, multiple masses of the hypopharynx and amyloidosis in supraglottic area in one patient each...
January 7, 2018: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
https://www.readbyqxmd.com/read/29365378/-the-significance-of-circulating-tumor-cells-in-head-and-neck-squamous-cell-carcinoma-a-preliminary-study
#17
H D Zhang, S C Gong, Y Q Liu, L J Liang, S B He, Q X Zhang, M Y Si, Z K Yu
Objective: To investigate the significance of circulating tumor cells (CTC) in squamous cell carcinoma of the head and neck (HNSCC). Methods: Twenty-four patients with HNSCC treated between October 2016 and July 2017 in our department were selected (experimental group), including 23 males and 1 females, aged 47-81 years. There were 14 cases of squamous cell carcinoma of larynx and 10 cases of hypopharynx, including I-Ⅱ stage (5 cases) and Ⅲ- Ⅳ stage (19 cases). All patients were primary and/or relapsed after treatment...
January 7, 2018: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
https://www.readbyqxmd.com/read/29365374/-clinical-application-of-supraclavicular-flap-for-oncologic-reconstruction-of-hypopharynx-and-upper-esophagus
#18
Y H Wen, W P Wen, Z F Wang, X L Zhu, A Y Jiang, L P Chai, W B Lei
Objective: To assess the efficacy of supraclavicular artery island flap (SCAIF) for the reconstruction of hypopharynx and upper esophagus. Methods: The SCAIF procedure on was used in 10 patients, including 8 with hypopharygeal carcinomas, 1 with esophageal carcinoma and neck skin invasion and 1 with hypopharyngeal leiomyosarcoma, at the Otorhinolaryngology Hospital, the First Affiliated Hospital, Sun Yatsen University between December 2015 and June 2017. The sizes of the flaps were measured in (4-8) cm×(5-12) cm...
January 7, 2018: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
https://www.readbyqxmd.com/read/29362131/59%C3%A2-years-old-male-with-local-advanced-adenoid-cystic-carcinoma-of-the-hypopharynx-a-case-report-and-a-review-of-the-literature
#19
REVIEW
Amr Muhammed, Ahmed Mohamed, Esraa Elnakib, Amal Omar, Nahawand Elnakib
Minor Salivary Gland tumours are rare, representing 2% of the head and neck tumours and less than 1% of hypopharyngeal cancers. The most common subtype of minor salivary gland tumours is adenoid cystic carcinoma. Although there are several case reports discussed it, there are only two reports discussing hypopharyngeal presentation in the literature, and they were treated by surgical resection. Despite that, our case report still to be unique as it presents a case of irresectable locally advanced tumour subjected to a trial of induction therapy...
February 2018: Oral Oncology
https://www.readbyqxmd.com/read/29361757/analysis-of-site-specific-methylation-of-tumor-related-genes-in-head-and-neck-cancer-potential-utility-as-biomarkers-for-prognosis
#20
Kiyoshi Misawa, Daiki Mochizuki, Atsushi Imai, Masato Mima, Yuki Misawa, Hiroyuki Mineta
Clarifying the epigenetic regulation of tumor-related genes (TRGs) can provide insights into the mechanisms of tumorigenesis and the risk for disease recurrence in HPV-negative head and neck cancers, originating in the hypopharynx, larynx, and oral cavity. We analyzed the methylation status of the promoters of 30 TRGs in 178 HPV-negative head and neck cancer patients using a quantitative methylation-specific PCR. Promoter methylation was correlated with various clinical characteristics and patient survival...
January 22, 2018: Cancers
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