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https://www.readbyqxmd.com/read/28350684/current-concepts-in-the-surgical-management-of-lymphedema
#1
Theodore A Kung, Manish C Champaneria, Jeffrey H Maki, Peter C Neligan
LEARNING OBJECTIVES: After studying this article, the participant should be able to: 1. Discuss the key points in diagnosing lymphedema. 2. Understand the imaging modalities that facilitate diagnosis and surgical planning. 3. Appreciate the indications for both physiologic and ablative procedures. 4. Recognize the potential role of lymphaticovenular anastomosis and vascularized lymph node transfer in the treatment of patients with lymphedema. SUMMARY: Lymphedema is an incurable disease caused by insufficient lymphatic drainage leading to abnormal accumulation of interstitial fluid within the soft tissues...
April 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28345284/role-of-fine-needle-aspiration-cytology-in-the-diagnosis-of-a-rare-case-of-a-poorly-differentiated-synovial-sarcoma-with-rhabdoid-features-including-treatment-implications
#2
Bharat Rekhi, Omshree Shetty, Mukta Ramadwar, Venkatesh Rangarajan, Jyoti Bajpai
Synovial sarcoma is a high-grade, soft tissue sarcoma that is relatively chemosensitive. Its exact diagnosis is crucial, including differentiation from its closest diagnostic mimic, ie, Ewing sarcoma, in view of different treatment options, including chemotherapy regimens, for both these tumors. A 15-year-old girl presented with a recurrent soft tissue mass in her right popliteal region, which was diagnosed as Ewing sarcoma, based on positive immunoexpression of MIC2/CD99, Fli1 and negative expression of LCA and desmin...
March 27, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28344600/staged-reconstruction-brachytherapy-has-lower-overall-cost-in-recurrent-soft-tissue-sarcoma
#3
Arash O Naghavi, Ricardo J Gonzalez, Jacob G Scott, Youngchul Kim, Yazan A Abuodeh, Tobin J Strom, Michelle Echevarria, John E Mullinax, Kamran A Ahmed, Louis B Harrison, Daniel C Fernandez
PURPOSE: Adjuvant brachytherapy (AB) with immediate (IR) and staged reconstruction (SR) are distinct treatment modalities available for patients with recurrent soft tissue sarcoma (STS). Although SR may offer local control and toxicity benefit, it requires additional upfront procedures, and there is no evidence that it improves overall survival. With the importance of value-based care, our goal is to identify which technique is more cost effective. MATERIAL AND METHODS: A retrospective review of 22 patients with recurrent extremity STS treated with resection followed by AB alone...
February 2017: Journal of Contemporary Brachytherapy
https://www.readbyqxmd.com/read/28343291/intercalary-frozen-autograft-for-reconstruction-of-malignant-bone-and-soft-tissue-tumours
#4
Karem M Zekry, Norio Yamamoto, Katsuhiro Hayashi, Akihiko Takeuchi, Takashi Higuchi, Kensaku Abe, Yuta Taniguchi, Ali Zein A A Alkhooly, Ahmed Saleh Abd-Elfattah, Ezzat H Fouly, Adel Refaat Ahmed, Hiroyuki Tsuchiya
PURPOSE: In 1999, we developed a technique using frozen autografts-tumour-containing bone treated with liquid nitrogen-for the reconstruction of malignant bone tumours. The purpose of this study was to evaluate the functional and oncological outcomes of frozen autografts for intercalary reconstruction of malignant bones and soft tissue tumours. METHODS: This retrospective study was designed to assess 34 patients of mean age 35 (range, 6-79) years. The mean follow-up period was 62 (24-214) months...
March 25, 2017: International Orthopaedics
https://www.readbyqxmd.com/read/28343024/sex-estimation-with-the-total-area-of-the-proximal-femur-a-densitometric-approach
#5
Francisco Curate, Anabela Albuquerque, Izilda Ferreira, Eugénia Cunha
The estimation of sex is a central step to establish the biological profile of an anonymous skeletal individual. Imaging techniques, including bone densitometry, have been used to evaluate sex in remains incompletely skeletonized. In this paper, we present a technique for sex estimation using the total area (TA) of the proximal femur, a two-dimensional areal measurement determined through densitometry. TA was acquired from a training sample (112 females; 112 males) from the Coimbra Identified Skeletal Collection (University of Coimbra, Portugal)...
March 8, 2017: Forensic Science International
https://www.readbyqxmd.com/read/28342738/american-brachytherapy-society-consensus-statement-for-soft-tissue-sarcoma-brachytherapy
#6
A O Naghavi, D C Fernandez, N Mesko, A Juloori, A Martinez, J G Scott, C Shah, L B Harrison
PURPOSE: Radiation therapy represents an essential treatment option in the management of soft tissue sarcomas (STS). Brachytherapy represents an important subset of radiation therapy techniques used for STS, with evolving indications and applications. Therefore, the purpose of this guideline was to update clinicians regarding the data surrounding brachytherapy (BT) and provide recommendations for the utilization of BT in patients with STS. METHODS AND MATERIALS: Members of the American Brachytherapy Society with expertise in STS, and STS BT in particular, created an updated guideline for the use of BT in STS based on a literature review and clinical experience...
March 22, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28342371/contrast-enhancement-with-uranyl-acetate-allows-quantitative-analysis-of-the-articular-cartilage-by-microct-application-to-mandibular-condyles-in-the-btx-rat-model-of-disuse
#7
Jean-Daniel Kün-Darbois, Florence Manero, Louis Rony, Daniel Chappard
Microcomputed tomography (microCT) is well adapted to quantitative analysis of calcified tissues but soft tissues (such as cartilage) are radiolucent and need a contrast enhancement procedure for microCT. We developed a "staining" method allowing microCT imaging of articular cartilage using uranyl acetate (UA). The method was used to see whether adult rats with a botulinum toxin (BTX) injection in masticatory muscles present a change at the condylar cartilage of the mandible in association with a localized trabecular bone loss...
March 21, 2017: Micron: the International Research and Review Journal for Microscopy
https://www.readbyqxmd.com/read/28341229/assessment-of-the-extension-of-pressure-ulcers-into-soft-tissue-and-osteomyelitis-diagnosis-using-18-f-fdg-pet-ct
#8
J R Garcia, M Soler, P Bassa, M Minoves, E Riera
The precise assessment of pressure ulcer extension in patients with neurological diseases has crucial therapeutic implications, especially in the early detection of fistula to interior structures and osteomyelitis. Two case reports are presented on patients with a similar ischial ulcer, in whom an (18)F-FDG PET/CT study enabled a precise assessment of infectious complications in underlying tissues. These cases support the implementation of (18)F-FDG PET/CT as a first-line technique in their management.
March 21, 2017: Revista Española de Medicina Nuclear e Imagen Molecular
https://www.readbyqxmd.com/read/28340673/the-advent-of-vascularized-composite-allotransplantation
#9
REVIEW
Curtis L Cetrulo, Zhi Yang Ng, Jonathan M Winograd, Kyle R Eberlin
Modern microsurgical techniques have made possible a broad spectrum of novel means for the reconstruction of complex bone and soft tissue defects. These techniques, in combination with developments in transplant immunology, have led to successful hand and facial allotransplantation and achievement of the highest rung in the reconstructive ladder - truly replacing like with like. The utilization of contemporary microsurgical technique in the context of vascularized composite allotransplantation (VCA) (1) permits successful technical execution and feasibility of VCA, (2) facilitates the study of immunologic tolerance in VCA preclinical models, and (3) optimizes functional VCA outcomes...
April 2017: Clinics in Plastic Surgery
https://www.readbyqxmd.com/read/28340670/keystone-and-pedicle-perforator-flaps-in-reconstructive-surgery-new-modifications-and-applications
#10
REVIEW
Jasson T Abraham, Michel Saint-Cyr
Pedicle perforator flaps and keystone perforator island flaps are additional tools for reconstructive surgeons. Advances in understanding of vascular anatomy, the dynamic nature of perforator perfusion, inter-perforator flow and the hot-spot principle have led to reconstructive techniques that allow innovative autologous tissue transfer while limiting donor site morbidity. Further modifications of the pedicle perforator flap have led to a multitude of freestyle pedicle perforator flap options, as well as freestyle free flaps for soft tissue reconstruction...
April 2017: Clinics in Plastic Surgery
https://www.readbyqxmd.com/read/28339445/transforaminal-endoscopic-decompression-for-a-giant-epidural-gas-containing-pseudocyst-a-case-report-and-literature-review
#11
Bin Zhu, Liang Jiang, Xiao Guang Liu
The isolated epidural gas-containing pseudocyst is an uncommon pathogenic factor for severe pain of the lower limb as a result of nerve root compression. After reviewing these rare cases reported in the literature, we found that the name, pathogenesis, and treatment strategy of this pathology remained controversial. The most common treatment is conservative treatment or percutaneous aspiration which might result inpoor pain relief and high recurrence rates. Moreover, the patient who received open surgery had good clinical outcome; however, he or she might experience a significant soft tissue injury...
March 2017: Pain Physician
https://www.readbyqxmd.com/read/28338036/to-cord-or-not-to-cord-that-is-still-a-question
#12
Analia Veitz-Keenan, James R Keenan
Data sourcesA broad computerised search with similar key terms was performed in different databases that included: Ovid Medline, Thomson's ISI Web of Science, PubMed, Science Direct, EMBASE and the Cochrane Library. Grey literature, dissertations, abstracts and theses were searched too. Reference lists of the selected articles were hand-searched.Study selectionThe inclusion criteria included in vivo randomised clinical trials and quasi-randomised clinical trials using gingival retraction techniques with and without cord...
March 2017: Evidence-based Dentistry
https://www.readbyqxmd.com/read/28337656/what-factors-are-associated-with-femoral-component-internal-rotation-in-tka-using-the-gap-balancing-technique
#13
Seung-Yup Lee, Hong-Chul Lim, Ki-Mo Jang, Ji-Hoon Bae
BACKGROUND: When using the gap-balancing technique for TKA, excessive medial release and varus proximal tibial resection can be associated with internal rotation of the femoral component. Previous studies have evaluated the causes of femoral component rotational alignment with a separate factor analysis using unadjusted statistical methods, which might result in treatment effects being attributed to confounding variables. QUESTIONS/PURPOSES: (1) What pre- and intraoperative factors are associated with internal rotation of the femoral component in TKA using the gap balancing technique? (2) To what degree does femoral component rotation as defined by the navigation system differ from rotation as measured by postoperative CT? METHODS: Three hundred seventy-seven knees that underwent computer-assisted primary TKA attributable to degenerative osteoarthritis with varus or mild valgus alignment in which medial soft tissue release was performed, and those with preoperative radiographs including preoperative CT between October 2007 and June 2014 were included in the study...
March 23, 2017: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/28337488/supercritical-carbon-dioxide-based-sterilization-of-decellularized-heart-valves
#14
Ryan S Hennessy, Soumen Jana, Brandon J Tefft, Meghana R Helder, Melissa D Young, Rebecca R Hennessy, Nicholas J Stoyles, Amir Lerman
OBJECTIVE: The goal of this research project encompasses finding the most efficient and effective method of decellularized tissue sterilization. BACKGROUND: Aortic tissue grafts have been utilized to repair damaged or diseased valves. Although, the tissues for grafting are collected aseptically, it does not eradicate the risk of contamination nor disease transfer. Thus, sterilization of grafts is mandatory. Several techniques have been applied to sterilize grafts; however, each technique shows drawbacks...
February 2017: JACC. Basic to Translational Science
https://www.readbyqxmd.com/read/28335262/nanomaterials-for-tissue-engineering-in-dentistry
#15
REVIEW
Manila Chieruzzi, Stefano Pagano, Silvia Moretti, Roberto Pinna, Egle Milia, Luigi Torre, Stefano Eramo
The tissue engineering (TE) of dental oral tissue is facing significant changes in clinical treatments in dentistry. TE is based on a stem cell, signaling molecule, and scaffold triad that must be known and calibrated with attention to specific sectors in dentistry. This review article shows a summary of micro- and nanomorphological characteristics of dental tissues, of stem cells available in the oral region, of signaling molecules usable in TE, and of scaffolds available to guide partial or total reconstruction of hard, soft, periodontal, and bone tissues...
July 21, 2016: Nanomaterials
https://www.readbyqxmd.com/read/28334371/comparative-study-of-functional-nasal-reconstruction-using-structural-reinforcement
#16
Waleed H Ezzat, Sara W Liu
Importance: Nasal reconstruction after Mohs surgery is a unique challenge in that it must satisfy both functional and aesthetic goals. Despite some advocacy in the literature for using structural reinforcement to achieve both functional and aesthetic outcomes in soft-tissue reconstruction, no study has validated this claim by comparing reconstruction with and without structural support. Objective: To evaluate the effectiveness of and need for structural reinforcement when reconstructing the nasal alar and sidewall subunits...
March 23, 2017: JAMA Facial Plastic Surgery
https://www.readbyqxmd.com/read/28333972/evaluation-of-high-resolution-in-vivo-mri-for-longitudinal-analysis-of-endochondral-fracture-healing-in-mice
#17
Melanie Haffner-Luntzer, Fabian Müller-Graf, Romano Matthys, Yvonne Hägele, Verena Fischer, René Jonas, Alireza Abaei, Florian Gebhard, Volker Rasche, Anita Ignatius
Mice are extensively used for experimental bone-healing studies. However, there are few established nondestructive in vivo techniques for longitudinal fracture-healing analysis in mice, including in vivo micro-computed tomography (μCT) and radiography. Importantly, none of the established methods can discriminate between non-mineralized fibrous tissue and cartilage in the soft fracture callus. Therefore, the objective was to establish high-resolution in vivo magnetic resonance imaging (MRI) for the longitudinal assessment of soft callus formation during bone healing in mice...
2017: PloS One
https://www.readbyqxmd.com/read/28333394/socket-shield-technique-for-immediate-implant-placement-clinical-radiographic-and-volumetric-data-after-5%C3%A2-years
#18
Daniel Bäumer, Otto Zuhr, Stephan Rebele, Markus Hürzeler
OBJECTIVES: Implant placement immediately after tooth extraction is often accompanied by resorption of surrounding tissues. A clinical technique was developed where the buccal portion of the root is retained to preserve the periodontal ligament and bundle bone. This technique is based on animal studies showing the potential to preserve the facial tissues utilizing this approach. The purpose of this study was to gain more insight regarding the safety of the technique with regard to biological and implant-related long-term complications and to observe the clinical appearance of the peri-implant tissues...
March 23, 2017: Clinical Oral Implants Research
https://www.readbyqxmd.com/read/28332083/phase-iii-soft-tissue-sarcoma-trials-success-or-failure
#19
REVIEW
Alexander T J Lee, Seth M Pollack, Paul Huang, Robin L Jones
Two recently reported phase III randomised control trials (RCTs) have resulted in the registration of two new systemic therapies for advanced soft tissue sarcoma. Both of these trials' designs were informed by phase II data that guided the selection of sensitive STS diagnoses, enabling the demonstration of benefit in certain subtypes. A number of other phase III trials reported in the last 18 months have seemingly fit into a recurrent pattern of failure-promising efficacy signals in earlier phase studies being lost in the survival follow-up of large, highly heterogeneous cohorts...
March 2017: Current Treatment Options in Oncology
https://www.readbyqxmd.com/read/28330705/advances-in-the-pathology-and-molecular-biology-of-sarcomas-and-the-impact-on-treatment
#20
K Thway, J Noujaim, R L Jones, C Fisher
Sarcomas are a complex group of childhood and adult neoplasms with differentiation towards mesenchymal tissues that can occur at almost every anatomic site. Although pathologically diverse, they frequently show similar clinical presentations and radiological findings, such that correct histopathologic diagnosis, utilising the appropriate ancillary immunohistochemical and molecular techniques, underpins their management. This article gives an overview of the pathology, coupled with recent advances in molecular biology, of a selection of soft tissue sarcomas from a clinicopathological perspective, discussing histopathological diagnosis with developments in molecular diagnosis and the incorporation of these findings into diagnostic practice and current and potential targeted treatments...
March 19, 2017: Clinical Oncology: a Journal of the Royal College of Radiologists
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