Sushil Sharma, Carolyn Seungyoun Moon, Azza Khogali, Ali Haidous, Anthony Chabenne, Comfort Ojo, Miriana Jelebinkov, Yousef Kurdi, Manuchair Ebadi
Parkinson's disease (PD) is the second most common neurodegenerative disorder mostly affecting the aging population over sixty. Cardinal symptoms including, tremors, muscle rigidity, drooping posture, drooling, walking difficulty, and autonomic symptoms appear when a significant number of nigrostriatal dopaminergic neurons are already destroyed. Hence we need early, sensitive, specific, and economical peripheral and/or central biomarker(s) for the differential diagnosis, prognosis, and treatment of PD. These can be classified as clinical, biochemical, genetic, proteomic, and neuroimaging biomarkers...
September 2013: Neurochemistry International