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dengue infection in thalassemia

Lucas Augusto Monteiro Castro Trigo, Fernanda Garanhani Surita, Mary Angela Parpinelli, Belmiro Gonçalves Pereira, Kleber Yotsumoto Fertrin, Maria Laura Costa
Beta thalassemia major is a rare hereditary blood disease in which impaired synthesis of beta globin chains causes severe anemia. Medical treatment consists of chronic blood transfusions and iron chelation. We describe two cases of adolescents with beta thalassemia major with unplanned pregnancies and late onset of prenatal care. One had worsening of anemia with increased transfusional requirement, fetal growth restriction, and placental senescence. The other was also diagnosed with hypothyroidism and low maternal weight, and was admitted twice during pregnancy due to dengue shock syndrome and influenza H1N1-associated respiratory infection...
June 2015: Revista Brasileira de Ginecologia e Obstetrícia
Kamon Phuakpet, Kleebsabai Sanpakit, Nassawee Vathana, Chayamon Takpradit, Kulkanya Chokephaibulkit, Vip Viprakasit
Infection-associated hemophagocytic syndrome (IAHS), a secondary form of hemophagocytic lymphohistiocytosis (HLH), has been found following several types of infections and can be fatal. We report herein a case of IAHS following dengue infection in a 14-year-old patient with underlying α-thalassemia syndrome (non-deletional Hb H/Hb Constant Spring disease). He developed prolonged fever, thrombocytopenia, and progressive splenomegaly. Further investigations indicated hyperferritinemia, and increased reactive histiocytes with hemophagocytic activity in the bone marrow...
August 2015: Pediatrics International: Official Journal of the Japan Pediatric Society
Wannapa Sornjai, Kornpat Khungwanmaythawee, Saovaros Svasti, Suthat Fucharoen, Phitchayapak Wintachai, Sutee Yoksan, Sukathida Ubol, Nitwara Wikan, Duncan R Smith
Dengue is the most significant arthropod borne viral disease worldwide, and infection with the dengue virus causes a wide range of symptoms in humans, including bone marrow suppression. While the target cells of the virus remain poorly characterized, cells of the myeloid lineage have been shown to be important mediators of the disease. This study sought to determine whether erythroid precursor cells were susceptible to dengue virus infection, and whether erythroid cells from thalassemia trait carriers showed any protection against infection...
December 2014: Virology
Vip Viprakasit, Supachai Ekwattanakit, Nipon Chalaow, Suchada Riolueang, Sirirat Wijit, Porntep Tanyut, Nunthawut Chat-Uthai, Kalaya Tachavanich
Alpha thalassemia is the most common genetic disease in the world with the prevalence of carriers ranging from 5-50% in several populations. Coinheritance of two defective α-globin genes usually gives rise to a symptomatic condition, hemoglobin (Hb) H disease. Previously, it has been suggested from several studies in different populations that nondeletional Hb H disease (--/α(T)α or --/αα(T)) is generally more severe than the deletional type (--/-α). In this report, we describe four rare nondeletional α-thalassemia mutations in Thai individuals, including initiation codon mutation (HBA2:c...
2014: Acta Haematologica
Ampaiwan Chuansumrit, Kanchana Tangnararatchakit, Nongnuch Sirachainan, Samart Pakakasamal, Suradej Hongeng, Wathanee Chaiyaratana, Pimpun Kitpoka, Sutee Yoksan
We studied anemia and bleeding risk among hematologic-oncologic pediatric patients with dengue infection. A total of 907 patients suspected of having dengue infection were included in the study. They were categorized into 2 groups: 1) patients with confirmed dengue infection (n=843) and 2) patients with other febrile illnesses (n = 64). Both groups included patients with underlying hematologic-oncologic diseases (55 vs 14) and without underlying disease (788 vs 50). Patients with underlying diseases were divided into 3 subgroups by risk: Subgroup A, anemia risk, including patients with thalassemia and hemoglobinopathies (n = 39) and G6PD deficiency (n=6); Subgroup B, patients with bleeding risk, including hemophilia (n = 7), von Willebrand disease (n = 1) and thrombocytopenia (n = 4); and Subgroup C, patients with anemia and bleeding risk, including oncologic diseases (n =12)...
March 2012: Southeast Asian Journal of Tropical Medicine and Public Health
K Ullah, P Ahmed, S Raza, T Satti, Q Nisa, S Mirza, F Akhtar, M K Kamal, F M Akhtar
One hundred and fifty-four patients received allogeneic stem cell transplantations from HLA-matched siblings for various hematological disorders from July 2001 to September 2006. Indications for transplantation included aplastic anemia (n=66), beta-thalassemia major (n=40), CML (n=33), acute leukemia (n=8), and miscellaneous disorders (n=7). One hundred and twenty patients were males and 34 were females. Median patient age was 14 years (range, 1(1/4)-54 years). All patients achieved successful engraftment. Median time to engraftment (ANC>0...
December 2007: Transplantation Proceedings
Bunchoo Pongtanakul, Nattee Narkbunnam, Gavivann Veerakul, Kleebsabai Sanpakit, Vip Viprakasit, Voravarn Tanphaichitr Tanphaichitr, Vinai Suvatte
Dengue hemorrhagic fever (DHF) causing by dengue viral infection is endemic in Thailand and Southeast Asian countries where thalassemias are prevalent. Thalassemic patients are also at risk to acquire dengue viral infections and to develop DHF. However, they can have different clinical manifestations and complications as well as more severity than general population requiring special awareness for proper diagnosis and management. We reported 20 thalassemic patients (10 boys and 10 girls) with DHF admitted to Department of Pediatrics, Siriraj Hospital during 1977 to 2001...
November 2005: Journal of the Medical Association of Thailand, Chotmaihet Thangphaet
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