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Asthma prevention

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https://www.readbyqxmd.com/read/29222627/pediatric-asthma-management-in-china-current-and-future-challenges
#1
Xiaojian Zhou, Jianguo Hong
The purpose of this report was to review the state of asthma diagnosis and treatment in China and to examine challenges in achieving earlier diagnosis and treatment. The prevalence of asthma in children in China has increased over past decades, and data published in 2013 indicated a prevalence of 3.0% in children aged 0-14 years. Although this prevalence has increased, the percentage of children with acute asthma attacks decreased from 86% in 2000 to 77% in 2010, and the frequency of hospitalizations for asthma attacks decreased from 54...
December 8, 2017: Paediatric Drugs
https://www.readbyqxmd.com/read/29221963/detection-of-ige-reactivity-to-a-handful-of-allergen-molecules-in-early-childhood-predicts-respiratory-allergy-in-adolescence
#2
Magnus Wickman, Christian Lupinek, Niklas Andersson, Danielle Belgrave, Anna Asarnoj, Marta Benet, Mariona Pinart, Sandra Wieser, Judith Garcia-Aymerich, Alexandra Baar, Göran Pershagen, Angela Simpson, Inger Kull, Anna Bergström, Erik Melén, Carl Hamsten, Josep M Antó, Jean Bousquet, Adnan Custovic, Rudolf Valenta, Marianne van Hage
BACKGROUND: Sensitization in early childhood may precede respiratory allergy in adolescence. METHODS: IgE reactivity against 132 allergen molecules was evaluated using the MeDALL microarray in sera obtained from a random sample of 786 children at the age of 4, 8 and 16years in a population based birth cohort (BAMSE). Symptoms were analyzed by questionnaire at ages 4, 8 and 16years. Clinically and independent relevant allergen molecules accounting for ≥90% of IgE reactivities in sensitized individuals and at all time-points were identified as risk molecules and used to predict respiratory allergy...
November 14, 2017: EBioMedicine
https://www.readbyqxmd.com/read/29214013/prediction-and-prevention-of-allergy-and-asthma-in-eaaci-journals-2016
#3
REVIEW
Jean Bousquet, Clive Grattan, Thomas Bieber, Paolo Matricardi, Hans Uwe Simon, Ulrich Wahn, Antonella Muraro, Peter W Hellings, Ioana Agache
The European Academy of Allergy and Clinical Immunology (EAACI) owns three journals: Allergy, Pediatric Allergy and Immunology and Clinical and Translational Allergy. One of the major goals of EAACI is to support health promotion in which prevention of allergy and asthma plays a critical role and to disseminate the knowledge of allergy to all stakeholders including the EAACI junior members.
2017: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/29212551/extracorporeal-membrane-oxygenation-for-life-threatening-asthma-refractory-to-mechanical-ventilation-analysis-of-the-extracorporeal-life-support-organization-registry
#4
Hye Ju Yeo, Dohyung Kim, Doosoo Jeon, Yun Seong Kim, Peter Rycus, Woo Hyun Cho
BACKGROUND: The use of extracorporeal membrane oxygenation (ECMO) in cases of near-fatal asthma (NFA) has increased, but the benefits and potential complications of this therapy have yet to be fully investigated. METHODS: Cases were extracted from the Extracorporeal Life Support Organization Registry between March 1992 and March 2016. All patients with a diagnosis of asthma (according to the International Classification of Diseases 9th edition), who also received ECMO, were extracted...
December 6, 2017: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/29208260/ghrelin-ameliorates-asthma-by-inhibiting-endoplasmic-reticulum-stress
#5
Tian Fu, Lei Wang, Qingdi Zeng, Yan Zhang, Baowei Sheng, Liping Han
BACKGROUND: This study aimed to confirm the ameliorative effect of ghrelin on asthma and investigate its mechanism. MATERIALS AND METHODS: The murine model of asthma was induced by ovalbumin (OVA) treatment and assessed by histological pathology and airway responsiveness to methacholine. The total and differential leukocytes were counted. Tumor necrosis factor α, interferon γ, interleukin-5 and interleukin-13 levels in bronchoalveolar lavage fluid were quantified by commercial kits...
December 2017: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/29206628/implementation-gaps-for-asthma-prevention-and-control
#6
REVIEW
Luciana K Tanno, Tari Haahtela, Moises A Calderon, Alvaro Cruz, Pascal Demoly
Asthma and allergic diseases can start in childhood and persist throughout life, but could also be manifested later, at any time for still misunderstood reasons. They are major chronic multifactorial respiratory diseases, for which prevention, early diagnosis and treatment is recognized as a priority for the Europe's public health policy and the United Nations. Given that allergy triggers (including infections, rapid urbanization leading to loss in biodiversity, pollution and climate changes) are not expected to change in a foreseeable future, it is imperative that steps are taken to develop, strengthen and optimize preventive and treatment strategies...
September 2017: Respiratory Medicine
https://www.readbyqxmd.com/read/29206100/exploring-the-use-of-ingenol-mebutate-to-prevent-non-melanoma-skin-cancer
#7
Zarqa Ali
Asthma is a serious global health issue and the most prevalent chronic disorder among Danish pregnant women. Exacerbations of asthma during pregnancy have been associated with increased risk of adverse pregnancy and perinatal outcomes, and by that making asthma a potential serious medical condition during pregnancy. Monitoring of asthma every four to six weeks is recommended during pregnancy, although evidence is lacking that following this recommendation will improve pregnancy outcome and, not least, be beneficial for all pregnant women with asthma...
December 2017: Danish Medical Journal
https://www.readbyqxmd.com/read/29206057/school-nurse-asthma-program-reduces-healthcare-utilization-in-children-with-persistent-asthma
#8
Michelle Trivedi, Janki Patel, Darleen Lessard, Ted Kremer, Nancy Byatt, Wanda Phipatanakul, Lori Pbert, Robert Goldberg
OBJECTIVE: We examined the impact of a novel, school nurse-supervised asthma therapy program on healthcare utilization. METHODS: We retrospectively reviewed charts of 84 children enrolled in this program in central Massachusetts between 2012 and 2015. Physicians identified children with persistent asthma and poor medication adherence. These children were enrolled in the program to receive daily-inhaled corticosteroid at school, supervised by their school nurse, with ongoing communication between physician's office and school nurse through the school year...
December 5, 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/29196001/allium-tuberosum-antidiabetic-and-hepatoprotective-activities
#9
Xingli Tang, Opeyemi J Olatunji, Yifeng Zhou, Xilin Hou
Allium tuberosum (AT) is traditionally used for treating nocturnal emissions, abdominal pain, diarrhea, sexual dysfunction and asthma. This study aimed at investigating the antidiabetic and hepatoprotective activities of the butyl alcohol fraction from the methanolic extract of A. tuberosum. For the antidiabetic activity, rats were induced with diabetes by intraperitoneal injection of 150mg/kg alloxan and treated for 30days with AT extract (100, 200 and 400mg/kg). Animals were sacrificed after the study and the fasting blood glucose (FBG), triglyceride (TG), total cholesterol (TC), HDL, malondialdehyde (MDA) catalase, superoxide dismutase and glutathione levels were determined...
December 2017: Food Research International
https://www.readbyqxmd.com/read/29193478/possible-therapeutic-effect-of-carvacrol-on-asthmatic-patients-a-randomized-double-blind-placebo-controlled-phase-ii-clinical-trial
#10
Azam Alavinezhad, Mohammad Reza Khazdair, Mohammad Hossein Boskabady
The relaxant effects of carvacrol, a phenolic monoterpene, on tracheal smooth muscle and its preventive effect on asthmatic animals were reported. The effect of carvacrol in asthmatic patients was examined in the placebo group (Group P, n = 11) receiving placebo and treatment group (Group C, n = 12), which received carvacrol capsule (1.2 mg/kg/day) for 2 months in a double-blind manner. Pulmonary function tests, respiratory symptoms, hematological indices, and high-sensitivity C-reactive protein (hs-CRP) were measured before, 1 and 2 months after starting treatment...
November 28, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/29189349/role-of-epigenetics-and-dna-damage-in-asthma
#11
Adil S Zahiruddin, J Andrew Grant, Sanjiv Sur
PURPOSE OF REVIEW: Although asthma is a common disease worldwide, its pathogenesis remains to be fully elucidated. There is increasing evidence of the interaction between epigenetics, DNA-damage, and environmental allergens in the development of asthma. In this review, we will focus on the role of epigenetics and DNA-damage in asthma. RECENT FINDINGS: There is growing evidence of environmental allergens, particularly house dust mite, stimulating oxidative DNA damage in airway epithelial cells...
November 16, 2017: Current Opinion in Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29184554/il-17-and-tnf-%C3%AE-are-key-mediators-of-moraxella-catarrhalis-triggered-exacerbation-of-allergic-airway-inflammation
#12
Safa Alnahas, Stefanie Hagner, Hartmann Raifer, Ayse Kilic, Georg Gasteiger, Reinier Mutters, Anne Hellhund, Immo Prinz, Olaf Pinkenburg, Alexander Visekruna, Holger Garn, Ulrich Steinhoff
Alterations of the airway microbiome are often associated with pulmonary diseases. For example, detection of the bacterial pathogen Moraxella catarrhalis in the upper airways is linked with an increased risk to develop or exacerbate asthma. However, the mechanisms by which M. catarrhalis augments allergic airway inflammation (AAI) remain unclear. We here characterized the cellular and soluble mediators of M. catarrhalis triggered excacerbation of AAI in wt and IL-17 deficient as well as in animals treated with TNF-α and IL-6 neutralizing antibodies...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29184504/the-anti-allergic-cromones-past-present-and-future
#13
REVIEW
Ajantha Sinniah, Samia Yazid, Roderick J Flower
The anti-allergic cromones were originally synthesized in the 1960s by Fisons Plc, and the first drug to emerge from this program, disodium cromoglycate was subsequently marketed for the treatment of asthma and other allergic conditions. Whilst early studies demonstrated that the ability of the cromones to prevent allergic reactions was due to their 'mast cell stabilizing' properties, the exact pharmacological mechanism by which this occurred, remained a mystery. Here, we briefly review the history of these drugs, recount some aspects of their pharmacology, and discuss two new explanations for their unique actions...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29183453/the-age-related-characteristics-of-adults-with-asthma-who-visited-emergency-departments-in-korea-from-2007-to-2012
#14
(no author information available yet)
BACKGROUND: Understanding the patterns of emergency department (ED) visits of patients with asthma is important for disease control and prevention of exacerbations. OBJECTIVE: This study aimed to investigate the characteristics of adult patients who visited EDs because of their asthma. METHODS: Patients with asthma, ages greater than or equal to 19 years old, who visited 117 EDs throughout Korea between January 2007 and December 2012 were identified in the National Emergency Department Information System (NEDIS) data base using theInternational Classification of Disease, 10th revision, codes J45 (asthma) and J46 (status asthmaticus)...
November 28, 2017: Allergy and Asthma Proceedings:
https://www.readbyqxmd.com/read/29182669/nkt-cells-contribute-to-basal-il-4-production-but-are-not-required-to-induce-experimental-asthma
#15
Christopher G McKnight, Suzanne C Morris, Charles Perkins, Zhenqi Zhu, David A Hildeman, Albert Bendelac, Fred D Finkelman
CD1d-deficiency results in a selective deletion of NKT cells in mice that is reported to prevent murine allergic airway disease (AAD). Because we find 2-3 fold lower basal IL-4 production in CD1d- mice than in wild-type (WT) mice, we hypothesized that the contribution made by NKT cells to AAD would depend on the strength of the stimulus used to induce the disease. Consequently, we compared CD1d-deficient mice to WT mice in the development of AAD, using several models of disease induction that differed in the type and dose of allergen, the site of sensitization and the duration of immunization...
2017: PloS One
https://www.readbyqxmd.com/read/29182620/broncho-vaxom-om-85-modulates-rhinovirus-docking-proteins-on-human-airway-epithelial-cells-via-erk1-2-mitogen-activated-protein-kinase-and-camp
#16
Michael Roth, Christian Pasquali, Daiana Stolz, Michael Tamm
BACKGROUND: Bronchial epithelial cells (BEC) are primary target for Rhinovirus infection through attaching to cell membrane proteins. OM-85, a bacterial extract, improves recovery of asthma and COPD patients after viral infections, but only part of the mechanism was addressed, by focusing on defined immune cells. OBJECTIVE: We therefore determined the effect of OM-85 on isolated primary human BEC of controls (n = 8), asthma patients (n = 10) and COPD patients (n = 9)...
2017: PloS One
https://www.readbyqxmd.com/read/29178673/viral-infections-and-associated-factors-that-promote-acute-exacerbations-of-asthma
#17
REVIEW
Chang Keun Kim, Zak Callaway, James E Gern
Despite asthma being the most common chronic childhood ailment, there is still much to learn about the disease. Early childhood infections with well-known or emerging viruses can lay the pathophysiologic framework for asthma development and exacerbation later in life, which may be due partly to alteration of the airway microbiome. Once asthma is established, acute exacerbations are usually associated with infections with respiratory viruses, such as rhinoviruses (RVs). Once again, there are bidirectional interactions between viruses and airway bacteria that appear to influence the severity of illness and the likelihood of exacerbation...
January 2018: Allergy, Asthma & Immunology Research
https://www.readbyqxmd.com/read/29177959/ambient-air-pollution-and-biomarkers-of-health-effect
#18
Di Yang, Xuan Yang, Furong Deng, Xinbiao Guo
Recently, the air pollution situation of our country is very serious along with the development of urbanization and industrialization. Studies indicate that the exposure of air pollution can cause a rise of incidence and mortality of many diseases, such as chronic obstructive pulmonary disease (COPD), asthma, myocardial infarction, and so on. However, there is now growing evidence showing that significant air pollution exposures are associated with early biomarkers in various systems of the body. In order to better prevent and control the damage effect of air pollution, this article summarizes comprehensively epidemiological studies about the bad effects on the biomarkers of respiratory system, cardiovascular system, and genetic and epigenetic system exposure to ambient air pollution...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29176836/competence-in-metered-dose-inhaler-technique-among-community-pharmacy-professionals-in-gondar-town-northwest-ethiopia-knowledge-and-skill-gap-analysis
#19
Sewunet Admasu Belachew, Fasil Tilahun, Tirsit Ketsela, Asnakew Achaw Ayele, Adeladlew Kassie Netere, Amanual Getnet Mersha, Tamrat Befekadu Abebe, Begashaw Melaku Gebresillassie, Henok Getachew Tegegn, Daniel Asfaw Erku
BACKGROUND: When compared to systemic administration, if used correctly inhalers deliver a smaller enough percent of the drug right to the site of action in the lungs, with a faster onset of effect and with reduced systemic availability that minimizes adverse effects. However, the health professionals' and patients' use of metered dose inhaler is poor. OBJECTIVE: This study was aimed to explore community pharmacy professionals' (pharmacists' and druggists') competency on metered dose inhaler (MDI) technique...
2017: PloS One
https://www.readbyqxmd.com/read/29175989/3-bromomethyl-2-chloro-4-methylsulfonyl-benzoic-acid-a-new-cause-of-sensitiser-induced-occupational-asthma-rhinitis-and-urticaria
#20
Hille Suojalehto, Kirsi Karvala, Saana Ahonen, Katriina Ylinen, Liisa Airaksinen, Katri Suuronen, Sari Suomela, Irmeli Lindström
OBJECTIVES: 3-(Bromomethyl)-2-chloro-4-(methylsulfonyl)-benzoic acid (BCMBA) has not previously been identified as a respiratory sensitiser. We detected two cases who presented respiratory and urticaria symptoms related to BCMBA and had positive skin prick tests to the agent. Subsequently, we conducted outbreak investigations at the BCMBA-producing factory and performed clinical examinations to confirm occupational diseases. METHODS: The outbreak investigations included observations of work processes, assessment of exposure, a medical survey with a questionnaire and skin prick tests with 0...
November 24, 2017: Occupational and Environmental Medicine
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