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https://www.readbyqxmd.com/read/29933387/nk-4-exerts-selective-regulatory-effects-on-the-activation-and-function-of-allergy-related-th2-cells
#1
Keizo Kohno, Satomi Koya-Miyata, Akira Harashima, Toshio Ariyasu, Shimpei Ushio
NK-4 is the main component of the antiallergic drug Lumin, which has been in popular usage since the early 1950s. In this study, we examined whether NK-4 exerts a regulatory effect on the activation and effector function of Th2 cells. NK-4 inhibited IL-4 production by anti-CD3ε mAb-stimulated BALB/c mouse spleen cells, whereas NK-4 had little effect on IFN-γ production. IL-4 and IL-5 secretion by anti-CD3ε mAb- or antigen-stimulated Th2 cells (D10.G4.1) was abrogated by NK-4 without affecting cell numbers, whereas IFN-γ secretion by activated Th1 cells was unchanged...
2018: PloS One
https://www.readbyqxmd.com/read/29932372/fibrin-patch-influences-the-expression-of-hypoxia-inducible-factor-1%C3%AE-and-nuclear-factor-%C3%AE%C2%BAbp65-factors-on-ischemic-intestinal-anastomosis
#2
Carlos García-Vásquez, María J Fernández-Aceñero, Soledad García Gómez-Heras, Carlos Pastor
The intestinal anastomotic failure is one of the most severe complications in gastrointestinal surgery. Despite the great surgical improvements during the last decade, anastomotic leak rates remain practically the same, with a dramatically high grade of morbidity for patients. Leakages are usually the final consequence of ischemia in the anastomosis, leading to tissue hypoxia. In response to hypoxia, the cell orchestrates a variety of coordinated responses in order to restore oxygen homeostasis. The molecular mechanism of hypoxia sensitivity involves oxygen sensing hydroxylases, prolyl-hydroxylases, orchestrating two main transcription factors related to induction of inflammation and angiogenesis, namely nuclear factor-κB and hypoxia-inducible factors...
June 2018: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/29923491/three-trocar-laparoscopic-cholecystectomy-under-spinal-anesthesia-in-a-patient-with-asthma
#3
F Tatulli, A Delcuratolo, A Caraglia, A Notarnicola, F P N Carbone, A Caputi
INTRODUCTION: Laparoscopy is perceived as the state-of-the-art technique for a wide variety of operations but is contraindicated by comorbidities such as respiratory diseases. We present the case of a patient affected by asthma who underwent a successful three-trocar low-pressure pneumoperitoneum under spinal anesthesia. CASE REPORT: A 58 year-old male with symptomatic gallstones had partly-controlled asthma and respiratory allergies. Potential bronchospasm was avoided by a less invasive laparoscopic technique...
May 2018: Il Giornale di Chirurgia
https://www.readbyqxmd.com/read/29922642/a-mixed-methods-approach-to-evaluate-partnerships-and-implementation-of-the-massachusetts-prevention-and-wellness-trust-fund
#4
Rebekka M Lee, Shoba Ramanadhan, Gina R Kruse, Charles Deutsch
Background: Strong partnerships are critical to integrate evidence-based prevention interventions within clinical and community-based settings, offering multilevel and sustainable solutions to complex health issues. As part of Massachusetts' 2012 health reform, The Prevention and Wellness Trust Fund (PWTF) funded nine local partnerships throughout the state to address hypertension, pediatric asthma, falls among older adults, and tobacco use. The initiative was designed to improve health outcomes through prevention and disease management strategies and reduce healthcare costs...
2018: Frontiers in Public Health
https://www.readbyqxmd.com/read/29921555/the-prevalence-and-risk-factors-of-atopic-dermatitis-in-6-8-year-old-first-graders-in-taipei
#5
Ciao-Lin Ho, Lu-I Chang, Wei-Fong Wu
BACKGROUND: Despite the advance in the understanding of etiology, pathophysiology and diagnosis of atopic dermatitis (AD), its prevalence has increased annually in Taiwan. PURPOSES: The purpose of this study is to explore the prevalence, and personal and environmental risk factors of AD. METHODS: A cross-sectional survey was conducted via health centers of elementary schools in Taipei city. We used the Chinese version of ISAAC questionnaire to examine possible personal and environmental risk factors of AD...
June 1, 2018: Pediatrics and Neonatology
https://www.readbyqxmd.com/read/29921489/examination-of-the-cut-off-values-for-a-questionnaire-used-to-evaluate-asthma-control-in-japanese-asthma-patients
#6
Yuji Tohda, Soichiro Hozawa, Hiroshi Tanaka
BACKGROUND: The Japan Asthma Control Survey (JACS) questionnaire, developed as a tool for measuring asthma control levels in Japanese asthma patients, was previously tested for its reliability and validity. However, many of the patients enrolled in the original validation study had mild asthma; thus a re-evaluation including severe cases was required to calculate more reliable cut-off values. METHODS: Pooled analysis of data from the original validation study and the subsequent medication guidance study including adult patients with severe asthma was conducted to calculate the JACS questionnaire cut-off values and to assess their sensitivity and specificity for identifying "well-controlled", "not well-controlled", and "poorly controlled" asthma as described in the Asthma Prevention and Management Guideline 2015 (JGL2015)...
June 16, 2018: Allergology International: Official Journal of the Japanese Society of Allergology
https://www.readbyqxmd.com/read/29921463/sublingual-immunotherapy-of-house-dust-mite-respiratory-allergy-in-china
#7
REVIEW
L Cheng, W-C Zhou
Sublingual immunotherapy (SLIT) has been widely used for the treatment of allergic respiratory diseases, but many problems remain unsolved. Currently available data suggest that SLIT is very effective in children and adults with IgE-mediated respiratory diseases. Most allergists in China generally believe that SLIT is suitable for allergic rhinitis and asthma due to its safety and tolerability. SLIT for three years is suitable for patients to acquire stable therapeutic effects, and the efficacy of single-allergen SLIT for polysensitized patients has also been confirmed...
June 16, 2018: Allergologia et Immunopathologia
https://www.readbyqxmd.com/read/29916584/-diagnostic-approach-to-occupational-allergic-respiratory-diseases
#8
Gabriella Guarnieri
OBJECTIVES: An accurate diagnosis of occupational allergic respiratory diseases is crucial because they are related to disability, loss of work and worsening of psychosocial and economic status of workers. Early diagnosis is therefore essential to prevent the progression of allergic respiratory diseases and to implement preventive measures. The most frequent occupational allergic respiratory diseases are asthma (OA) and rhinitis (OR), less frequently hypersensitivity pneumonia (HP) and non-asthmatic eosinophilic bronchitis (NAEB)...
November 2017: Giornale Italiano di Medicina del Lavoro Ed Ergonomia
https://www.readbyqxmd.com/read/29915220/predicta-chip-based-high-resolution-diagnosis-of-rhinovirus-induced-wheeze
#9
Katarzyna Niespodziana, Katarina Stenberg-Hammar, Spyridon Megremis, Clarissa R Cabauatan, Kamila Napora-Wijata, Phyllis C Vacal, Daniela Gallerano, Christian Lupinek, Daniel Ebner, Thomas Schlederer, Christian Harwanegg, Cilla Söderhäll, Marianne van Hage, Gunilla Hedlin, Nikolaos G Papadopoulos, Rudolf Valenta
Rhinovirus (RV) infections are major triggers of acute exacerbations of severe respiratory diseases such as pre-school wheeze, asthma and chronic obstructive pulmonary disease (COPD). The occurrence of numerous RV types is a major challenge for the identification of the culprit virus types and for the improvement of virus type-specific treatment strategies. Here, we develop a chip containing 130 different micro-arrayed RV proteins and peptides and demonstrate in a cohort of 120 pre-school children, most of whom had been hospitalized due to acute wheeze, that it is possible to determine the culprit RV species with a minute blood sample by serology...
June 18, 2018: Nature Communications
https://www.readbyqxmd.com/read/29912647/the-association-between-local-meteorological-changes-and-exacerbation-of-acute-wheezing-in-kandy-sri-lanka
#10
N D B Ehelepola, Kusalika Ariyaratne, Amithe Jayaratne
BACKGROUND: Severe wheezing is a common medical emergency. Past studies have demonstrated associations between exacerbation of wheezing and meteorological factors and atmospheric pollution. There are no past studies from Sri Lanka that analyzed correlation between daily multiple meteorological variables and exacerbation of wheezing. OBJECTIVES: To determine the correlations between daily counts of patients nebulized at the Outpatient Department (OPD) of Teaching Hospital - Kandy (THK) and local meteorological variables, and to explore the utility of that information...
2018: Global Health Action
https://www.readbyqxmd.com/read/29909018/successful-treatment-of-eosinophilic-otitis-media-associated-with-severe-bronchial-asthma-with-an-anti-il-5-monoclonal-antibody-mepolizumab
#11
Isao Suzaki, Yurika Kimura, Akihiko Tanaka, Kojiro Hirano, Atsushi Ishibashi, Tomomi Mizuyoshi, Izumi Ando, Tatsuya Kitajima, So Watanabe, Yasuyuki Hinonira, Hitome Kobayashi
Eosinophilic otitis media (EOM), which is characterized by the accumulation of eosinophils in middle ear effusion and the middle ear mucosa, is a refractory type of otitis media that is often associated with asthma. Although an early diagnosis and appropriate treatment are necessary to prevent the progression of hearing loss in patients with EOM, there are currently no well-established treatments for this condition. We treated a 60-year-old male patient with asthma and EOM. The patient's asthma was poorly controlled, despite the use of high-dose inhaled corticosteroids, long-acting beta-agonist treatment, and the regular use of systemic corticosteroids...
June 13, 2018: Auris, Nasus, Larynx
https://www.readbyqxmd.com/read/29908539/the-effects-of-allium-cepa-extract-on-tracheal-responsiveness-lung-inflammatory-cells-and-phospholipase-a2-level-in-asthmatic-rats
#12
Vahideh Ghorani, Narges Marefati, Farzaneh Shakeri, Ramin Rezaee, Marzie Boskabady, Mohammad Hossein Boskabady
Antioxidant, antimicrobial, anti-hyperglycaemic, anti-diabetic and anti-inflammatory effects of Allium cepa (A. cepa) have been previously shown. In this study, the effects of A. cepa aqueous-alcoholic extract on tracheal responsiveness, lung inflammatory cells and phospholipase A2 (PLA2) level in bronchoalveolar fluid (BALF) of asthmatic rats were examined. Wistar rats were randomly divided into control group (C), asthmatic group (A), asthmatic group (A) treated with A. cepa extract (AC, 0.175, 0.35, and 0...
June 2018: Iranian Journal of Allergy, Asthma, and Immunology
https://www.readbyqxmd.com/read/29907668/longterm-outcomes-of-188-japanese-patients-with-eosinophilic-granulomatosis-with-polyangiitis
#13
Aiko Saku, Shunsuke Furuta, Masaki Hiraguri, Kei Ikeda, Yoshihisa Kobayashi, Shin-Ichiro Kagami, Kazuhiro Kurasawa, Ryutaro Matsumura, Daiki Nakagomi, Takao Sugiyama, Takeshi Umibe, Norihiko Watanabe, Hiroshi Nakajima
OBJECTIVE: Patients with eosinophilic granulomatosis with polyangiitis (EGPA) frequently experience relapses, which lead to cumulative organ damage. In this retrospective observational study, we aimed to reveal the risk factors for relapse in EGPA. METHODS: A total of 188 Japanese patients with EGPA diagnosed between 1996 and 2015 were identified from medical records in 10 hospitals. The diagnosis was based on the American College of Rheumatology 1990 criteria or Lanham's criteria...
June 15, 2018: Journal of Rheumatology
https://www.readbyqxmd.com/read/29907132/association-between-multiple-comorbidities-and-self-rated-health-status-in-middle-aged-and-elderly-chinese-the-china-kadoorie-biobank-study
#14
Xingyue Song, Jing Wu, Canqing Yu, Wenhong Dong, Jun Lv, Yu Guo, Zheng Bian, Ling Yang, Yiping Chen, Zhengming Chen, An Pan, Liming Li
BACKGROUND: Understanding the correlates of self-rated health (SRH) can help public health professionals prioritize health-promotion and disease-prevention interventions. This study aimed to investigate the association between multiple comorbidities and global SRH and age-comparative SRH. METHODS: A total of 512,891 participants aged 30-79 years old were recruited into the China Kadoorie Biobank study from ten regions between 2004 and 2008. Multivariate logistic regression models were used to estimate the odds ratios (ORs) for the associations between comorbidities (including diabetes, hypertension, coronary heart disease, rheumatic heart disease, stroke, tuberculosis, emphysema/bronchitis, asthma, cirrhosis/chronic hepatitis, peptic ulcer, gallbladder disease, kidney disease, fracture, rheumatic arthritis, psychiatric disorders, depressive symptoms, neurasthenia, head injury and cancer) and SRH...
June 15, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29906536/mahuang-decoction-mitigates-airway-inflammation-and-regulates-il-21-stat3-signaling-pathway-in-rat-asthma-model
#15
Yu He, Xiaohui Lou, Zhan Jin, Li Yu, Ling Deng, Haitong Wan
ETHNOPHARMACOLOGICAL RELEVANCE: Nowadays, bronchial asthma is still a severe disease threatening human health, and it is incumbent upon us to seek effective therapeutic drugs. Mahuang decoction (MHD), a classic famous Chinese prescription, has been used for thousands of years to prevent phlegm from forming, stop coughing and relieve asthma, but the relevant mechanism has not been thoroughly clarified. This study aims to investigate the anti-airway inflammation effect of MHD and the possible molecular mechanism underlying IL21/STAT3 signaling pathway, so as to provide guidance for the treatment of MHD on bronchial asthma...
June 12, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29906501/repurposing-drugs-as-inhaled-therapies-in-asthma
#16
Sandra D Anderson
For the first 40 years of the 20th century treatment for asthma occurred in response to an asthma attack. The treatments were given by injection or orally and included the adrenergic agonists adrenalin/epinephrine and ephedrine and a phosphodiesterase inhibitor theophylline. Epinephrine became available as an aerosol in 1930. After 1945, isoprenaline, a non-selective beta agonist, became available for oral use but it was most widely used by inhalation. Isoprenaline was short-acting with unwanted cardiac effects...
June 12, 2018: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/29904584/new-targets-for-resolution-of-airway-remodeling-in-obstructive-lung-diseases
#17
REVIEW
Ajay P Nayak, Deepak A Deshpande, Raymond B Penn
Airway remodeling (AR) is a progressive pathological feature of the obstructive lung diseases, including asthma and chronic obstructive pulmonary disease (COPD). The pathology manifests itself in the form of significant, progressive, and (to date) seemingly irreversible changes to distinct respiratory structural compartments. Consequently, AR correlates with disease severity and the gradual decline in pulmonary function associated with asthma and COPD. Although current asthma/COPD drugs manage airway contraction and inflammation, none of these effectively prevent or reverse features of AR...
2018: F1000Research
https://www.readbyqxmd.com/read/29904394/relationship-between-25-hydroxyvitamin-d-levels-and-inflammatory-factors-in-children-with-asthma-attack
#18
Shang Wang, Yao Pan, Zhenkun Zhang
The level of 25-hydroxyvitamin D [25-(OH)D] associated with inflammatory factors in children during an asthma attack was investigated. In total, 60 child patients, who were admitted and treated in the Affiliated Children's Hospital of Xuzhou Medical University from March 2015 to March 2017, during their asthma attacks, were selected as the observation group. The patients were divided into the high 25-(OH)D (n=28) and low 25-(OH)D (n=32) groups according to the median level of 25-(OH)D. A total of 30 healthy children were selected as the control group...
June 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29895495/flavonoids-as-th1-th2-cytokines-immunomodulators-a-systematic-review-of-studies-on-animal-models
#19
REVIEW
Gopalsamy Rajiv Gandhi, Maria Terezinha Santos Leite Neta, Rajiv Gandhi Sathiyabama, Jullyana de Souza Siqueira Quintans, Ana Mara de Oliveira E Silva, Adriano Antunes de Souza Araújo, Narendra Narain, Lucindo José Quintans Júnior, Ricardo Queiroz Gurgel
BACKGROUND: Flavonoids are naturally occurring compounds, extensively distributed in plants. T helper (Th)1 and Th2 cytokines balance plays an essential role in the reaction of inflammatory, allergic and infectious processes and transplantation rejection. PURPOSE: This systematic review focuses on various classes of flavonoids with a view to evaluate whether Th1/Th2 cytokine-mediated pathways of immunoenhancement could reduce immune overwhelming reactions. METHODS: Articles in English published from inception to December 2017 reporting flavonoids with immunomodulatory activity for the management of immune-mediated disorders were acquired from PubMed, EMBASE, Scopus and Web of Science and a animal experiments where Th1 and Th2 cytokines were investigated to assess the outcome of immunoregulatory therapy were included...
May 15, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29893775/new-onset-asthma-and-combat-deployment-findings-from-the-millennium-cohort-study
#20
Anna C Rivera, Teresa M Powell, Edward J Boyko, Rachel U Lee, Dennis J Faix, David D Luxton, Rudolph P Rull
Recent reports suggest United States military service members who deployed in support of the recent conflicts in Iraq and Afghanistan have higher rates of new-onset asthma than those who did not deploy. However, it is unknown whether combat experiences, in addition to deployment, contribute to new-onset asthma risk. This study aimed to longitudinally determine the risk factors for developing asthma, including combat deployment (categorized as deployed with combat experience, deployed without combat experience, and nondeployed), among Millennium Cohort Study participants from 2001 to 2013...
June 11, 2018: American Journal of Epidemiology
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