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"Dynamic functional connectivity"

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https://www.readbyqxmd.com/read/28714584/oscillations-during-observations-dynamic-oscillatory-networks-serving-visuospatial-attention
#1
Alex I Wiesman, Elizabeth Heinrichs-Graham, Amy L Proskovec, Timothy J McDermott, Tony W Wilson
The dynamic allocation of neural resources to discrete features within a visual scene enables us to react quickly and accurately to salient environmental circumstances. A network of bilateral cortical regions is known to subserve such visuospatial attention functions; however the oscillatory and functional connectivity dynamics of information coding within this network are not fully understood. Particularly, the coding of information within prototypical attention-network hubs and the subsecond functional connections formed between these hubs have not been adequately characterized...
July 17, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/28713261/age-related-decline-in-the-variation-of-dynamic-functional-connectivity-a-resting-state-analysis
#2
Yuanyuan Chen, Weiwei Wang, Xin Zhao, Miao Sha, Ya'nan Liu, Xiong Zhang, Jianguo Ma, Hongyan Ni, Dong Ming
Normal aging is typically characterized by abnormal resting-state functional connectivity (FC), including decreasing connectivity within networks and increasing connectivity between networks, under the assumption that the FC over the scan time was stationary. In fact, the resting-state FC has been shown in recent years to vary over time even within minutes, thus showing the great potential of intrinsic interactions and organization of the brain. In this article, we assumed that the dynamic FC consisted of an intrinsic dynamic balance in the resting brain and was altered with increasing age...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/28712995/investigations-into-within-and-between-subject-resting-state-amplitude-variations
#3
Janine Bijsterbosch, Samuel Harrison, Eugene Duff, Fidel Alfaro-Almagro, Mark Woolrich, Stephen Smith
The amplitudes of spontaneous fluctuations in brain activity may be a significant source of within-subject and between-subject variability, and this variability is likely to be carried through into functional connectivity (FC) estimates (whether directly or indirectly). Therefore, improving our understanding of amplitude fluctuations over the course of a resting state scan and variation in amplitude across individuals is of great relevance to the interpretation of FC findings. We investigate resting state amplitudes in two large-scale studies (HCP and UK Biobank), with the aim of determining between-subject and within-subject variability...
July 13, 2017: NeuroImage
https://www.readbyqxmd.com/read/28707166/altered-dynamic-functional-connectivity-in-the-default-mode-network-in-patients-with-cirrhosis-and-minimal-hepatic-encephalopathy
#4
Hua-Jun Chen, Hai-Long Lin, Qiu-Feng Chen, Peng-Fei Liu
PURPOSE: Abnormal brain intrinsic functional connectivity (FC) has been documented in minimal hepatic encephalopathy (MHE) by static connectivity analysis. However, changes in dynamic FC (dFC) remain unknown. We aimed to identify altered dFC within the default mode network (DMN) associated with MHE. METHODS: Resting-state functional MRI data were acquired from 20 cirrhotic patients with MHE and 24 healthy controls. DMN seed regions were defined using seed-based FC analysis (centered on the posterior cingulate cortex (PCC))...
July 13, 2017: Neuroradiology
https://www.readbyqxmd.com/read/28687517/comparing-test-retest-reliability-of-dynamic-functional-connectivity-methods
#5
Ann S Choe, Mary Beth Nebel, Anita D Barber, Jessica R Cohen, Yuting Xu, James J Pekar, Brian Caffo, Martin A Lindquist
Due to the dynamic, condition-dependent nature of brain activity, interest in estimating rapid functional connectivity (FC) changes that occur during resting-state functional magnetic resonance imaging (rs-fMRI) has recently soared. However, studying dynamic FC is methodologically challenging, due to the low signal-to-noise ratio of the blood oxygen level dependent (BOLD) signal in fMRI and the massive number of data points generated during the analysis. Thus, it is important to establish methods and summary measures that maximize reliability and the utility of dynamic FC to provide insight into brain function...
July 5, 2017: NeuroImage
https://www.readbyqxmd.com/read/28684334/just-a-thought-how-mind-wandering-is-represented-in-dynamic-brain-connectivity
#6
REVIEW
Aaron Kucyi
The neuroscience of mind-wandering has begun to flourish, with roles of brain regions and networks being defined for various components of spontaneous thought. However, often underappreciated is that most of brain activity does not represent immediately occurring thoughts. Instead, spontaneous, organized network activity largely reflects "intrinsic" functions that are unrelated to the current experience. There remains no consensus on how brain networks represent mind-wandering in parallel to functioning in other ongoing, predominantly unconscious processes...
July 3, 2017: NeuroImage
https://www.readbyqxmd.com/read/28665045/extraction-of-dynamic-functional-connectivity-from-brain-grey-matter-and-white-matter-for-mci-classification
#7
Xiaobo Chen, Han Zhang, Lichi Zhang, Celina Shen, Seong-Whan Lee, Dinggang Shen
Brain functional connectivity (FC) extracted from resting-state fMRI (RS-fMRI) has become a popular approach for diagnosing various neurodegenerative diseases, including Alzheimer's disease (AD) and its prodromal stage, mild cognitive impairment (MCI). Current studies mainly construct the FC networks between grey matter (GM) regions of the brain based on temporal co-variations of the blood oxygenation level-dependent (BOLD) signals, which reflects the synchronized neural activities. However, it was rarely investigated whether the FC detected within the white matter (WM) could provide useful information for diagnosis...
June 30, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/28583880/slow-5-dynamic-functional-connectivity-reflects-the-capacity-to-sustain-cognitive-performance-during-pain
#8
J C Cheng, R L Bosma, K S Hemington, A Kucyi, M A Lindquist, K D Davis
Some individuals are more distracted by pain during a cognitive task than others, representing poor pain coping. We have characterized individuals as A-type (attention dominates) or P-type (pain dominates) based on how pain interferes with task speed. The ability to optimize behavior during pain may relate to the flexibility in communication at rest between the dorsolateral prefrontal cortex (DLPFC) of the executive control network, and the anterior mid-cingulate cortex (aMCC) of the salience network (SN) - regions involved in cognitive-interference...
June 3, 2017: NeuroImage
https://www.readbyqxmd.com/read/28578129/assessing-dynamic-functional-connectivity-in-heterogeneous-samples
#9
B C L Lehmann, S R White, R N Henson, Cam-Can, L Geerligs
Several methods have been developed to measure dynamic functional connectivity (dFC) in fMRI data. These methods are often based on a sliding-window analysis, which aims to capture how the brain's functional organization varies over the course of a scan. The aim of many studies is to compare dFC across groups, such as younger versus older people. However, spurious group differences in measured dFC may be caused by other sources of heterogeneity between people. For example, the shape of the haemodynamic response function (HRF) and levels of measurement noise have been found to vary with age...
June 1, 2017: NeuroImage
https://www.readbyqxmd.com/read/28553208/childhood-trauma-and-functional-connectivity-between-amygdala-and-medial-prefrontal-cortex-a-dynamic-functional-connectivity-and-large-scale-network-perspective
#10
Josh M Cisler
Altered functional connectivity (FC) between the medial prefrontal cortex (mPFC) and amygdala is widely implicated as a neural mechanism explaining risk for psychopathology among those exposed to early life trauma. Nonetheless, contemporary neuroimaging research has shifted toward large-scale network models of brain function, and it is not clear how this common bi-nodal finding fits into larger-scale network models. Here, using dynamic functional connectivity (DFC) approaches combined with large-scale network analyses, the larger role of bi-nodal FC between mPFC and amygdala among a sample of adolescent girls is investigated...
2017: Frontiers in Systems Neuroscience
https://www.readbyqxmd.com/read/28456172/structural-connectome-topology-relates-to-regional-bold-signal-dynamics-in-the-mouse-brain
#11
Sarab S Sethi, Valerio Zerbi, Nicole Wenderoth, Alex Fornito, Ben D Fulcher
Brain dynamics are thought to unfold on a network determined by the pattern of axonal connections linking pairs of neuronal elements; the so-called connectome. Prior work has indicated that structural brain connectivity constrains pairwise correlations of brain dynamics ("functional connectivity"), but it is not known whether inter-regional axonal connectivity is related to the intrinsic dynamics of individual brain areas. Here we investigate this relationship using a weighted, directed mesoscale mouse connectome from the Allen Mouse Brain Connectivity Atlas and resting state functional MRI (rs-fMRI) time-series data measured in 184 brain regions in eighteen anesthetized mice...
April 2017: Chaos
https://www.readbyqxmd.com/read/28447220/track-weighted-dynamic-functional-connectivity-tw-dfc-a-new-method-to-study-time-resolved-functional-connectivity
#12
Fernando Calamante, Robert E Smith, Xiaoyun Liang, Andrew Zalesky, Alan Connelly
Interest in the study of brain connectivity is growing, particularly in understanding the dynamics of the structural/functional connectivity relation. Structural and functional connectivity are most often analysed independently of each other. Track-weighted functional connectivity (TW-FC) was recently proposed as a means to combine structural/functional connectivity information into a single image. We extend here TW-FC in two important ways: first, all the functional data are used without having to define a prior functional network (cf...
April 26, 2017: Brain Structure & Function
https://www.readbyqxmd.com/read/28440813/instability-of-default-mode-network-connectivity-in-major-depression-a-two-sample-confirmation-study
#13
T Wise, L Marwood, A M Perkins, A Herane-Vives, R Joules, D J Lythgoe, W-M Luh, S C R Williams, A H Young, A J Cleare, D Arnone
Major depression is associated with altered static functional connectivity in various brain networks, particularly the default mode network (DMN). Dynamic functional connectivity is a novel tool with little application in affective disorders to date, and holds the potential to unravel fluctuations in connectivity strength over time in major depression. We assessed stability of connectivity in major depression between the medial prefrontal cortex (mPFC) and posterior cingulate cortex (PCC), key nodes in the DMN that are implicated in ruminative cognitions...
April 25, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/28417233/a-posterior-to-anterior-shift-of-brain-functional-dynamics-in-aging
#14
Han Zhang, Annie Lee, Anqi Qiu
Convergent evidence from task-based functional magnetic resonance imaging (fMRI) studies suggests a posterior-to-anterior shift as an adaptive compensatory scaffolding mechanism for aging. This study aimed to investigate whether brain functional dynamics at rest follow the same scaffolding mechanism for aging using a large Chinese sample aged from 22 to 79 years (n = 277). We defined a probability of brain regions being hubs over a period of time to characterize functional hub dynamic, and defined variability of the functional connectivity to characterize dynamic functional connectivity using resting-state fMRI...
April 17, 2017: Brain Structure & Function
https://www.readbyqxmd.com/read/28383052/high-transition-frequencies-of-dynamic-functional-connectivity-states-in-the-creative-brain
#15
Junchao Li, Delong Zhang, Aiying Liang, Bishan Liang, Zengjian Wang, Yuxuan Cai, Mengxia Gao, Zhenni Gao, Song Chang, Bingqing Jiao, Ruiwang Huang, Ming Liu
Creativity is thought to require the flexible reconfiguration of multiple brain regions that interact in transient and complex communication patterns. In contrast to prior emphases on searching for specific regions or networks associated with creative performance, we focused on exploring the association between the reconfiguration of dynamic functional connectivity states and creative ability. We hypothesized that a high frequency of dynamic functional connectivity state transitions will be associated with creative ability...
April 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28366871/single-dose-of-mirtazapine-modulates-whole-brain-functional-connectivity-during-emotional-narrative-processing
#16
Emma Komulainen, Enrico Glerean, Katarina Meskanen, Roope Heikkilä, Lauri Nummenmaa, Tuukka T Raij, Jari Lahti, Pekka Jylhä, Tarja Melartin, Erkki Isometsä, Jesper Ekelund
The link between neurotransmitter-level effects of antidepressants and their clinical effect remain poorly understood. A single dose of mirtazapine decreases limbic responses to fearful faces in healthy subjects, but it is unknown whether this effect applies to complex emotional situations and dynamic connectivity between brain regions. Thirty healthy volunteers listened to spoken emotional narratives during functional magnetic resonance imaging (fMRI). In an open-label design, 15 subjects received 15mg of mirtazapine two hours prior to fMRI while 15 subjects served as a control group...
May 30, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28359293/memory-performance-related-dynamic-brain-connectivity-indicates-pathological-burden-and-genetic-risk-for-alzheimer-s-disease
#17
Frances C Quevenco, Maria G Preti, Jiri M G van Bergen, Jun Hua, Michael Wyss, Xu Li, Simon J Schreiner, Stefanie C Steininger, Rafael Meyer, Irene B Meier, Adam M Brickman, Sandra E Leh, Anton F Gietl, Alfred Buck, Roger M Nitsch, Klaas P Pruessmann, Peter C M van Zijl, Christoph Hock, Dimitri Van De Ville, Paul G Unschuld
BACKGROUND: The incidence of Alzheimer's disease (AD) strongly relates to advanced age and progressive deposition of cerebral amyloid-beta (Aβ), hyperphosphorylated tau, and iron. The purpose of this study was to investigate the relationship between cerebral dynamic functional connectivity and variability of long-term cognitive performance in healthy, elderly subjects, allowing for local pathology and genetic risk. METHODS: Thirty seven participants (mean (SD) age 74 (6...
March 31, 2017: Alzheimer's Research & Therapy
https://www.readbyqxmd.com/read/28295837/compromised-hippocampus-striatum-pathway-as-a-potential-imaging-biomarker-of-mild-traumatic-brain-injury-and-posttraumatic-stress-disorder
#18
D Rangaprakash, Gopikrishna Deshpande, Thomas A Daniel, Adam M Goodman, Jennifer L Robinson, Nouha Salibi, Jeffrey S Katz, Thomas S Denney, Michael N Dretsch
OBJECTIVES: Military service members risk acquiring posttraumatic stress disorder (PTSD) and mild-traumatic brain injury (mTBI), with high comorbidity. Owing to overlapping symptomatology in chronic mTBI or postconcussion syndrome (PCS) and PTSD, it is difficult to assess the etiology of a patient's condition without objective measures. Using resting-state functional MRI in a novel framework, we tested the hypothesis that their neural signatures are characterized by functionally hyperconnected brain regions which are less variable over time...
June 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/28294459/identifying-dynamic-functional-connectivity-biomarkers-using-gig-ica-application-to-schizophrenia-schizoaffective-disorder-and-psychotic-bipolar-disorder
#19
Yuhui Du, Godfrey D Pearlson, Dongdong Lin, Jing Sui, Jiayu Chen, Mustafa Salman, Carol A Tamminga, Elena I Ivleva, John A Sweeney, Matcheri S Keshavan, Brett A Clementz, Juan Bustillo, Vince D Calhoun
Functional magnetic resonance imaging (fMRI) studies have shown altered brain dynamic functional connectivity (DFC) in mental disorders. Here, we aim to explore DFC across a spectrum of symptomatically-related disorders including bipolar disorder with psychosis (BPP), schizoaffective disorder (SAD), and schizophrenia (SZ). We introduce a group information guided independent component analysis procedure to estimate both group-level and subject-specific connectivity states from DFC. Using resting-state fMRI data of 238 healthy controls (HCs), 140 BPP, 132 SAD, and 113 SZ patients, we identified measures differentiating groups from the whole-brain DFC and traditional static functional connectivity (SFC), separately...
May 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/28269506/mining-cross-frequency-coupling-microstates-from-resting-state-meg-an-application-to-mild-traumatic-brain-injury
#20
Marios Antonakakis, Stavros I Dimitriadis, Michalis Zervakis, Andrew C Papanicolaou, George Zouridakis
Recent studies have investigated the possible role of dynamic functional connectivity and the role of cross-frequency coupling (CFC) to provide the substrate for reliable biomarkers of brain disorders. In this study, we analyzed time-varying CFC profiles from resting state Magnetoencephal-ographic recordings of 30 mild Traumatic Brain Injury (mTBI) patients and 50 normal controls. Interactions among sensors at specific pairs of frequency bands were computed via estimation of phase-to-amplitude couplings. We then computed time-varying functional connectivity graphs that were described in terms of segregation (local efficiency, LE) and integration (global efficiency, GE) and mapped those graphs to time series of GE/LE estimates...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
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