keyword
MENU ▼
Read by QxMD icon Read
search

Rational care

keyword
https://www.readbyqxmd.com/read/29781548/multi-omics-in-high-grade-serous-ovarian-cancer-biomarkers-from-genome-to-the-immunome
#1
Cole Clifford, Natasha Vitkin, Sarah Nersesian, Gillian Reid-Schachter, Julie-Ann Francis, Madhuri Koti
Epithelial ovarian cancer (EOC) is a lethal gynaecological disease that imposes significant burden on health care and patient quality of life. High-grade serous carcinoma of the ovary (HGSC) is the most prevalent histological type of EOC. A vast majority of HGSC cases are diagnosed at late stages of the disease, limiting the opportunity for clinical intervention and resulting in a 10-year survival rate of <20%. Recent innovations in high-throughput molecular analysis of patient-derived specimens may address these clinical challenges by providing an enhanced understanding of the molecular aetiology of ovarian cancer, in addition to offering several opportunities for rational biomarker and targeted therapy discovery...
May 21, 2018: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/29777966/determinants-of-choice-of-delivery-place-testing-rational-choice-theory-and-habitus-theory
#2
Anja Broda, Juliane Krüger, Stephanie Schinke, Andreas Weber
OBJECTIVE: The current study uses two antipodal social science theories, the rational choice theory and the habitus theory, and applies these to describe how women choose between intraclinical (i.e., hospital-run birth clinics) and extraclinical (i.e., midwife-led birth centres or home births) delivery places. DESIGN, SETTING, PARTICIPANTS, MEASUREMENTS: Data were collected in a cross-sectional questionnaire-based survey among 189 women. A list of 22 determinants, conceptualized to capture the two theoretical concepts, were rated on a 7-point Likert scale with 1 = unimportant to 7 = very important...
May 7, 2018: Midwifery
https://www.readbyqxmd.com/read/29776398/primary-bacterial-ventriculitis-in-adults-an-emergent-diagnosis-challenge-report-of-a-meningoccal-case-and-review-of-the-literature
#3
Anaïs Lesourd, Nicolas Magne, Anaïs Soares, Caroline Lemaitre, Muhamed-Kheir Taha, Isabelle Gueit, Michel Wolff, François Caron
BACKGROUND: Defined by an infection of the ventricular system of the brain, ventriculitis is usually known as a health-care associated infection. In contrast, primary pyogenic ventriculitis complicating community-acquired meningitis is uncommon, and mainly described in infants. Only seven cases that have occured in adults have been found in the international literature. CASE PRESENTATION: We report here a new case due to Neisseria meningitidis occurring in an 85 year-old-man...
May 18, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29774819/midurethral-slings
#4
Joao P Zambon, Catherine Ann Matthews, Gopal H Badlani
Urinary incontinence (UI) is a common symptom affecting almost one-third of adult women. UI can occur because of hypermobility or intrinsic sphincter deficiency of the urethra. Regardless its etiology, it is associated with poor quality of life and most of the incontinent women develop symptoms such as anxiety, depression, and social isolation over time. The synthetic midurethral sling (MUS) was first introduced in 1995 and quickly became the gold standard treatment for women with stress UI because of intrinsic sphincter deficiency and/or urethral hypermobility...
May 2018: Journal of Endourology
https://www.readbyqxmd.com/read/29773268/recent-therapeutic-advances-in-juvenile-idiopathic-arthritis
#5
REVIEW
Gabriella Giancane, Alessandra Alongi, Silvia Rosina, Jessica Tibaldi, Alessandro Consolaro, Angelo Ravelli
Over the past two decades, the management of juvenile idiopathic arthritis (JIA) has been revolutionized by the increased tendency toward early aggressive interventions and the availability of the novel biologic medications. In 2017, three novel randomized controlled trials have evaluated the effectiveness and tolerability of golimumab and tocilizumab in polyarticular JIA, and shown that methotrexate may increase and prolong the effect of intra-articular corticosteroid injection in children with oligoarthritis...
August 2017: Best Practice & Research. Clinical Rheumatology
https://www.readbyqxmd.com/read/29772886/urban-environmental-clustering-to-assess-the-spatial-dynamics-of-aedes-aegypti-breeding-sites
#6
Guillermo Albrieu-Llinás, Manuel O Espinosa, Agustín Quaglia, Marcelo Abril, Carlos Marcelo Scavuzzo
The identification of Aedes aegypti breeding hotspots in urban areas is crucial for the rational design of control strategies against this disease vector. Remote sensing and geographic information systems offer valuable tools for mapping habitat suitability of a given area. However, predicting species occurrences by means of probability distribution maps based on transversal entomological surveys has limited utility for local authorities. The aim of the present study was to carefully examine the temporal evolution of the number of houses infested with immature stages of Ae...
May 7, 2018: Geospatial Health
https://www.readbyqxmd.com/read/29771203/understanding-how-nurses-ration-care
#7
Clare Lynette Harvey, Shona Thompson, Eileen Willis, Alannah Meyer, Maria Pearson
Purpose The purpose of this paper is to explore how nurses make decisions to ration care or leave it undone within a clinical environment that is controlled by systems level cost containment. The authors wanted to find out what professional, personal and organisational factors contribute to that decision-making process. This work follows previous international research that explored missed nursing care using Kalisch and Williams' MISSCARE survey. Design/methodology/approach The authors drew on the care elements used by Kalisch and Williams, asking nurses to tell us how they decided what care to leave out, the conduits for which could include delaying care during a shift, delegating care to another health professional on the same shift, handing care over to staff on the next shift or leaving care undone...
May 21, 2018: Journal of Health Organization and Management
https://www.readbyqxmd.com/read/29768117/experiences-and-expectations-of-bereavement-contact-among-caregivers-of-patients-with-advanced-cancer
#8
Maisam Makarem, Shan Mohammed, Nadia Swami, Ashley Pope, Nanor Kevork, Monika Krzyzanowska, Gary Rodin, Breffni Hannon, Camilla Zimmermann
BACKGROUND: Contact with bereaved caregivers is not standard practice among cancer physicians, and little is known about its impact on caregivers. OBJECTIVE: Our aim was to describe the experiences and opinions of caregivers regarding bereavement contact from healthcare providers (HCP). DESIGN: Semistructured qualitative interviews were conducted with 61 bereaved caregivers. SUBJECTS: Bereaved caregivers of advanced cancer patients who had completed a randomized controlled trial of an early palliative care intervention were approached one to five years after the patient's death...
May 16, 2018: Journal of Palliative Medicine
https://www.readbyqxmd.com/read/29765241/prevalence-of-antibiotic-prescription-in-southern-italian-outpatients-real-world-data-analysis-of-socioeconomic-and-sociodemographic-variables-at-a-municipality-level
#9
Veronica Russo, Valeria Marina Monetti, Francesca Guerriero, Ugo Trama, Antonella Guida, Enrica Menditto, Valentina Orlando
Purpose: The aim of this study was to analyze the geographic variation in systemic antibiotic prescription at a regional level and to explore the influence of socioeconomic and sociodemographic variables. Methods: This study was a retrospective analysis of reimbursement pharmacy records in the outpatient settings of Italy's Campania Region in 2016. Standardized antibiotic prescription rates were calculated at municipality and Local Health Unit (LHU) level. Antibiotic consumption was analyzed as defined daily doses (DDD)/1000 inhabitants per day (DID)...
2018: ClinicoEconomics and Outcomes Research: CEOR
https://www.readbyqxmd.com/read/29764384/caesarean-section-audit-to-improve-quality-of-care-in-a-rural-referral-hospital-in-tanzania
#10
Luuk Dekker, Tessa Houtzager, Omary Kilume, John Horogo, Jos van Roosmalen, Angelo Sadock Nyamtema
BACKGROUND: Caesarean section (CS) is often a life-saving procedure, but can also lead to serious complications, even more so in low-resource settings. Therefore unnecessary CS should be avoided and optimal circumstances for vaginal delivery should be created. In this study, we aim to audit indications for Caesarean sections and improve decision-making and obstetric management. METHODS: Audit of all cases of CS performed from January to August 2013 was performed in a rural referral hospital in Tanzania...
May 15, 2018: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29756633/immunotherapy-in-head-and-neck-cancer-scientific-rationale-current-treatment-options-and-future-directions
#11
Uta Rothschild, Laurent Muller, Axel Lechner, Hans A Schlösser, Dirk Beutner, Heinz Läubli, Alfred Zippelius, Sacha I Rothschild
Head and neck squamous cell carcinoma (HNSCC) is a frequent tumour arising from multiple anatomical subsites in the head and neck region. The treatment for early-stage disease is generally single modality, either surgery or radiotherapy. The treatment for locally advanced tumours is multimodal. For recurrent/metastatic HNSCC palliative chemotherapy is standard of care. The prognosis is limited and novel treatment approaches are urgently needed. HNSCC evades immune responses through multiple resistance mechanisms...
May 14, 2018: Swiss Medical Weekly
https://www.readbyqxmd.com/read/29755996/evaluation-of-clinical-pharmacy-services-in-the-intensive-care-unit-of-a-tertiary-university-hospital-in-the-northwest-of-iran
#12
Ata Mahmoodpoor, Arman Kalami, Kamran Shadvar, Taher Entezari-Maleki, Hadi Hamishehkar
Objective: Current literature indicates that the presence of clinical pharmacists in hospitals results in improved patient care, rational drug therapy, and treatment costs. This study assessed the clinical pharmacy services in the intensive care unit (ICU) of a tertiary hospital at Tabriz University of Medical Sciences, Iran. Methods: During a 9-month cross-sectional study (2014-2015), the clinical pharmacy interventions in 27 sessions and educational activities for patients and health-care professionals were randomly assessed based on the Australian guideline and standard of practice for clinical pharmacy...
January 2018: Journal of Research in Pharmacy Practice
https://www.readbyqxmd.com/read/29754828/prehabilitation-and-functional-recovery-for-colorectal-cancer-patients
#13
REVIEW
Enrico Maria Minnella, Francesco Carli
Cancer and its treatments are associated with functional decline that has impactful consequences on quality of life, and care continuum. Thus, optimizing perioperative functional capacity has been identified as a research and clinical priority in cancer care. The process of enhancing physical fitness before an operation to enable the patient to withstand the stress of surgery has been termed prehabilitation. Main elements are preoperative exercise, nutrition therapy, and anxiety-reduction techniques. Given the growing body of evidence on prehabilitation efficacy, this narrative review will summarize the rational underlying preoperative interventions, and propose a structured clinical pathway aimed at optimizing preoperative functional capacity...
April 30, 2018: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29748754/rational-selection-criticality-assessment-and-tiering-of-quality-attributes-and-test-methods-for-analytical-similarity-evaluation-of-biosimilars
#14
Kristof Vandekerckhove, Andreas Seidl, Hiten Gutka, Manish Kumar, Gyöngyi Gratzl, David Keire, Todd Coffey, Henriette Kuehne
Leading regulatory agencies recommend biosimilar assessment to proceed in a stepwise fashion, starting with a detailed analytical comparison of the structural and functional properties of the proposed biosimilar and reference product. The degree of analytical similarity determines the degree of residual uncertainty that must be addressed through downstream in vivo studies. Substantive evidence of similarity from comprehensive analytical testing may justify a targeted clinical development plan, and thus enable a shorter path to licensing...
May 10, 2018: AAPS Journal
https://www.readbyqxmd.com/read/29745393/the-physical-chemistry-and-materials-science-behind-sinter-resistant-catalysts
#15
Yunqian Dai, Ping Lu, Zhenming Cao, Charles T Campbell, Younan Xia
Catalyst sintering, a main cause of the loss of catalytic activity and/or selectivity at high reaction temperatures, is a major concern and grand challenge in the general area of heterogeneous catalysis. Although all heterogeneous catalysts are inevitably subjected to sintering during their operation, the immediate and drastic consequences can be mitigated by carefully engineering the catalytic particles and their interactions with the supports. In this tutorial review, we highlight recent progress in understanding the physical chemistry and materials science involved in sintering, including the discussion of advanced techniques, such as in situ microscopy and spectroscopy, for investigating the sintering process and its rate...
May 10, 2018: Chemical Society Reviews
https://www.readbyqxmd.com/read/29744827/solid-state-nmr-structural-characterization-of-self-assembled-peptides-with-selective-13-c-and-15-n-isotopic-labels
#16
Danting Huang, Benjamin C Hudson, Yuan Gao, Evan K Roberts, Anant K Paravastu
For the structural characterization methods discussed here, information on molecular conformation and intermolecular organization within nanostructured peptide assemblies is discerned through analysis of solid-state NMR spectral features. This chapter reviews general NMR methodologies, requirements for sample preparation, and specific descriptions of key experiments. An attempt is made to explain choices of solid-state NMR experiments and interpretation of results in a way that is approachable to a nonspecialist...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29741257/laboratory-diagnosis-of-clinically-relevant-platelet-function-disorders
#17
REVIEW
P Gresele, E Falcinelli, L Bury
Inherited platelet function disorders (IPFDs) represent a significant fraction of congenital hemorrhagic disorders, and may be associated with bleeding of considerable severity. IPFDs may be difficult to diagnose and a preliminary accurate clinical examination and an objective evaluation of the severity of the bleeding history are mandatory. The laboratory investigation of IPFDs should follow a rational algorithm based on a streamlined panel of laboratory tests with subsequent steps of increasing levels of complexity...
May 2018: International Journal of Laboratory Hematology
https://www.readbyqxmd.com/read/29741210/language-barriers-and-epistemic-injustice-in-healthcare-settings
#18
Yael Peled
Contemporary realities of global population movement increasingly bring to the fore the challenge of quality and equitable health provision across language barriers. While this linguistic challenge is not unique to immigration contexts and is likewise shared by health systems responding to the needs of aboriginal peoples and other historical linguistic minorities, the expanding multilingual landscape of receiving societies renders this challenge even more critical, owing to limited or even non-existing familiarity of modern and often monolingual health systems with the particular needs of new linguistic minorities...
May 9, 2018: Bioethics
https://www.readbyqxmd.com/read/29740990/prevalence-of-multiple-sclerosis-in-croatia-data-from-national-and-non-governmental-organization-registries
#19
Tomislav Benjak, Vesna Štefančić, Željka Draušnik, Ivan Cerovečki, Dijana Roginić, Mario Habek, Sandra Mihel, Ranko Stevanović
AIM: To update the estimate of multiple sclerosis (MS) prevalence in Croatia using multiple epidemiological tools. METHODS: This level IV, epidemiological study gathered data from three national patient registries and one database of a non-governmental MS patients' organization. Data were extracted on all individuals who had undergone hospital MS treatment, consulted their primary health care providers about MS-related symptoms, been listed as having MS-related disability, or been members of the mentioned non-governmental organization in 2015...
April 30, 2018: Croatian Medical Journal
https://www.readbyqxmd.com/read/29735549/mechanistic-distinctions-between-chk1-and-wee1-inhibition-guide-the-scheduling-of-triple-therapy-with-gemcitabine
#20
Siang-Boon Koh, Yann Wallez, Charles R Dunlop, Sandra Bernaldo de Quirós Fernández, Tashinga E Bapiro, Frances M Richards, Duncan I Jodrell
Combination of cytotoxic therapy with emerging DNA damage response inhibitors (DDRi) has been limited by tolerability issues. However, the goal of most combination trials has been to administer DDRi with standard-of-care doses of chemotherapy. We hypothesised that mechanism-guided treatment scheduling could reduce the incidence of dose-limiting toxicities and enable tolerable multitherapeutic regimens. Integrative analyses of mathematical modelling and single-cell assays distinguished the synergy kinetics of WEE1i from CHK1i by potency, spatiotemporal perturbation, and mitotic effects when combined with gemcitabine...
May 7, 2018: Cancer Research
keyword
keyword
119649
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"