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https://www.readbyqxmd.com/read/28637449/task-shifting-interpersonal-counseling-for-depression-a-pragmatic-randomized-controlled-trial-in-primary-care
#1
Camila T Matsuzaka, Milton Wainberg, Andrea Norcini Pala, Elis V Hoffmann, Bruno M Coimbra, Rosaly F Braga, Annika C Sweetland, Marcelo F Mello
BACKGROUND: Task shifting approaches (rational redistribution of tasks among health workforce teams) to train lay professionals to assist with integrating mental health treatment in primary care has been recommended to close the mental health treatment gap for depression in low- and middle-income countries. This study aims to examine the a new model for depression care in a low-resource environment compared to enhanced treatment at usual (E-TAU). METHODS: We trained non-specialist community health workers (local lay employees of the public health system) to provide Interpersonal Counseling (IPC) to treat depressive symptoms in the Brazilian, São Paulo city, family health strategy (FHS)...
June 21, 2017: BMC Psychiatry
https://www.readbyqxmd.com/read/28635336/new-advances-in-focal-therapy-for-early-stage-prostate-cancer
#2
Kae Jack Tay, Ariel A Schulman, Christina Sze, Efrat Tsivian, Thomas J Polascik
Prostate focal therapy offers men the opportunity to achieve oncological control while preserving sexual and urinary function. The prerequisites for successful focal therapy are to accurately identify, localize and completely ablate the clinically significant cancer(s) within the prostate. We aim to evaluate the evidence for current and upcoming technologies that could shape the future of prostate cancer focal therapy in the next five years. Areas Covered: Current literature on advances in patient selection using imaging, biopsy and biomarkers, ablation techniques and adjuvant treatments for focal therapy are summarized...
June 21, 2017: Expert Review of Anticancer Therapy
https://www.readbyqxmd.com/read/28633469/a-framework-illustrating-care-seeking-among-older-adults-in-a-hospital-emergency-department
#3
Barbara J Lutz, Allyson G Hall, Sean B Vanhille, Andrea L Jones, Jessica R Schumacher, Phyllis Hendry, Jeffrey S Harman, Donna L Carden
Background and Objectives: Older adults seeking emergency department (ED) care often have multiple, complex chronic conditions. We sought to understand factors that influence ED care-seeking by older adults and present a theoretical framework illustrating this process. Research Design and Methods: In this grounded theory study, we interviewed 40 older adults with chronic illness within 90 days of an ED visit to explore their decision-making about seeking ED care...
June 17, 2017: Gerontologist
https://www.readbyqxmd.com/read/28632822/-strategies-to-reduce-infections-and-antibiotic-use-and-its-effects-in-a-neonatal-care-unit
#4
Soledad Urzúa, Marcela Ferrés, Patricia García, Amparo Sánchez, Matías Luco
INTRODUCTION: Late onset sepsis (LOS) remains an important cause of morbidity and mortality in neonatal intensive care units (NICU). The empirical use of vancomycin and other broad spectrum antibiotics is very frequent and is associated with the emergence of resistant agents, infection by gram-negative bacilli (GNB), fungal infections and increased morbidity and mortality. OBJECTIVE: To evaluate the impact of 5 intervention protocols designed to reduce infections and promote the rational use of antibiotics (AB) in a single NICU...
April 2017: Revista Chilena de Infectología: órgano Oficial de la Sociedad Chilena de Infectología
https://www.readbyqxmd.com/read/28631481/3d-graphene-ni-foam-as-an-advanced-electrode-for-high-performance-non-aqueous-redox-flow-batteries
#5
Kyubin Lee, Jungkuk Lee, Kyeong-Woo Kwon, Min-Sik Park, Jin-Ha Hwang, Ki Jae Kim
Electrodes composed of multi-layered graphene grown on a metal foam (GMF) were prepared by directly growing multi-layer graphene sheets on a three-dimensional (3D) Ni-foam substrate via a self-catalyzing chemical vapor deposition process. The multi-layer graphene sheets are successfully grown on the Ni-foam substrate surface, maintaining the unique 3D macroporous structure of the Ni foam. The potential use of GMF electrodes in non-aqueous redox flow batteries (RFBs) is carefully examined using [Co(bpy)3]+/2+ and [Fe(bpy)3]2+/3+ redox couples...
June 20, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28628930/-rational-use-of-antibiotics-data-form-a-survey-from-2014-within-the-mrdo-network-compared-to-nationwide-data-from-2009
#6
Luba Lendowski, Peter Walger, Christoph Hoeser, Martin Exner, Claudia Roesing, Steffen Engelhart
Introduction To combat multi-resistant gram-negative bacteria as the cause of life-threatening infections, antibiotic stewardship activities are of great importance. Objective To detect weaknesses when prescribing antibiotics in hospitals and compare the situation between 2009 and 2014. Methods In 2014, a questionnaire was sent to all 380 physicians employed in 7 hospitals. Primary, secondary and tertiary care hospitals were included. Investigated were: demographic data, position, certified specialization, presence of antibiotic prescription rules and behavior to follow them...
June 19, 2017: Das Gesundheitswesen
https://www.readbyqxmd.com/read/28626850/prescribing-indicators-in-primary-health-care-in-belo-horizonte-brazil-associated-factors
#7
Marina Guimarães Lima, Kátia Reis Dutra, Ursula Carolina Morais Martins
Background The prescription is one of the factors that influences rational use of medicines. The evaluation of prescribing indicators should contribute to organization of primary health care services. Objective The aim of this study was to evaluate prescribing indicators and associated factors in primary health care in the northeast health district, Belo Horizonte, Brazil. Setting Twenty primary health care units in the Northeast Health District, Belo Horizonte, Brazil. Method The study was cross sectional...
June 19, 2017: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/28622013/acetazolamide-usage-in-severe-chronic-obstructive-pulmonary-disease-pros-and-cons
#8
Rosemary Adamson, Erik R Swenson
Acetazolamide is a carbonic anhydrase (CA) inhibitor sometimes used as a respiratory stimulant for patients with COPD with the goal of improving oxygenation, reducing carbon dioxide retention and aiding liberation from mechanical ventilation and/or attempting to correct a metabolic alkalosis. However, the net effect of CA inhibition is multifactorial and complex since CA is inhibited in many tissues that may negatively affect the patient with lung disease. The full impact of acetazolamide and other CA inhibitors depends critically on dosing, age, and pulmonary, renal, hepatic, hematological, and respiratory muscle function and reserves...
June 16, 2017: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/28620841/device-based-approaches-for-the-treatment-of-arterial-hypertension
#9
REVIEW
Jens Jordan
Device-based antihypertensive treatments have primarily been developed and clinically tested for patients with hypertension refractory to pharmacological treatment. Most but not all device-based treatments target the sympathetic nervous system and provided important new insight in the mechanisms of human hypertension. This review provides an overview on the scientific rational and clinical data on recent device-based antihypertensive treatment approaches. Device-based treatments targeting the sympathetic nervous system include catheter-based renal nerve ablation, electrical carotid sinus stimulation, modulation of baroreflex transduction through a dedicated carotid stent, carotid body denervation, and deep brain stimulation...
July 2017: Current Hypertension Reports
https://www.readbyqxmd.com/read/28618777/rare-earth-pcu-mof-platform-based-on-re4-%C3%AE-3-oh-4-coo-62-clusters-rational-design-directed-synthesis-and-deliberate-tuning-of-excitation-wavelengths
#10
Tian-Yi Luo, Chong Liu, Svetlana V Eliseeva, Patrick Flynn Muldoon, Stephane Petoud, Nathaniel L Rosi
The Td point group symmetry of rare earth (RE3+) metal clusters RE4(μ3-OH)4(COO)62+ makes them attractive building blocks for creating metal-organic frameworks (MOFs) with controllable topologies. Herein, we describe the design and synthesis of a series of isoreticular MOFs featuring pcu topology [MOF-1114(RE) and MOF-1115(RE)] with variable rare earth metal ions (RE3+ = Y3+, Sm3+, Eu3+, Gd3+, Tb3+, Dy3+, Ho3+, Er3+, Tm3+, Yb3+) and linear amino-functionalized dicarboxylate linkers of different lengths. In total, we report 22 MOFs that vary in both composition and structure yet share the same RE4(μ3-OH)4 cluster motif...
June 15, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28616815/-prevention-of-nosocomial-infections-and-antibiotic-resistance-in-nursing-homes
#11
REVIEW
Markus Bleckwenn, Judith Hammerschmidt, Claudia Rösing, Manuela Klaschik
BACKGROUND: Nosocomial infections and multidrug-resistant organisms are an increasing problem in nursing homes worldwide; therefore, new approaches for infection control need to be developed. OBJECTIVES: This article gives an overview of infections in nursing homes, their medical treatment and previous measures for infection prevention. MATERIALS AND METHODS: The article is based on a selective literature search including the literature database PubMed...
June 14, 2017: Zeitschrift Für Gerontologie und Geriatrie
https://www.readbyqxmd.com/read/28615004/understanding-heart-failure-explaining-telehealth-a-hermeneutic-systematic-review
#12
Trisha Greenhalgh, Christine A'Court, Sara Shaw
BACKGROUND: Enthusiasts for telehealth extol its potential for supporting heart failure management. But randomised trials have been slow to recruit and produced conflicting findings; real-world roll-out has been slow. We sought to inform policy by making sense of a complex literature on heart failure and its remote management. METHODS: Through database searching and citation tracking, we identified 7 systematic reviews of systematic reviews, 32 systematic reviews (including 17 meta-analyses and 8 qualitative reviews); six mega-trials and over 60 additional relevant empirical studies and commentaries...
June 14, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/28614518/rationalization-and-sensemaking-in-care-management-an-experience-of-change-in-a-hospital-of-the-sus-unified-health-system
#13
Creuza da Silva Azevedo, Marilene de Castilho Sá, Marcela Cunha, Gustavo Correa Matta, Lilian Miranda, Victor Grabois
This study aimed to analyze organizational processes of change in the hospital care management by using qualitative evaluation developed in the case study. The study was developed at the Hospital Fornecedores de Cana de Piracicaba, in São Paulo State, Brazil, in September and October of 2012. There were 25 interviews with members of the senior board of directors of the hospital, managers and health professionals linked to healthcare of adults, in addition to the analysis of managerial documents and observations of some activities...
June 2017: Ciência & Saúde Coletiva
https://www.readbyqxmd.com/read/28614427/a-new-era-of-thromboelastometry
#14
Tomaz Crochemore, Felipe Maia de Toledo Piza, Roseny Dos Reis Rodrigues, João Carlos de Campos Guerra, Leonardo José Rolim Ferraz, Thiago Domingos Corrêa
Severe hemorrhage with necessity of allogeneic blood transfusion is common complication in intensive care unit and is associated with increased morbidity and mortality. Prompt recognition and treatment of bleeding causes becomes essential for the effective control of hemorrhage, rationalizing the use of allogeneic blood components, and in this way, preventing an occurrence of their potential adverse effects. Conventional coagulation tests such as prothrombin time and activated partial thromboplastin time present limitations in predicting bleeding and guiding transfusion therapy in critically ill patients...
June 12, 2017: Einstein
https://www.readbyqxmd.com/read/28611011/application-of-plasma-genotyping-technologies-in-non-small-cell-lung-cancer-a-practical-review
#15
REVIEW
Adrian G Sacher, Kimberly M Komatsubara, Geoffrey R Oxnard
The rational treatment of metastatic NSCLC hinges upon the timely detection of potentially targetable genomic alterations in order to guide therapy. Recent advances in highly sensitive genotyping technologies have allowed for the development of novel plasma genotyping assays which are capable of noninvasively detecting targetable alterations in plasma cell-free DNA without reliance on traditional tissue genotyping. The rapid development of plasma genotyping has led to an explosion in the number of assay platforms available from both commercial and laboratory sources...
June 10, 2017: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/28608713/a-case-study-seclusion-and-restraint-in-psychiatric-care
#16
Marie-Hélène Goulet, Caroline Larue
A wide breadth of research has recognized that seclusion and restraint affects patients, staff, and organizations alike. Therefore, it is essential to understand the viewpoints of all stakeholders to improve practices. The study aimed to understand the context in which seclusion and restraint practices are employed based on the perceptions of staff and inpatients in a psychiatric ward. A case study was performed using a participatory approach. Methods included a 56-hr immersion in the practice setting and individual interviews with staff and patients ( n = 17)...
June 1, 2017: Clinical Nursing Research
https://www.readbyqxmd.com/read/28605179/component-matters-paving-the-roadmap-toward-enhanced-electrocatalytic-performance-of-graphitic-c3n4-based-catalysts-via-atomic-tuning
#17
Zengxia Pei, Jingxing Gu, Yukun Wang, Zijie Tang, Zhuoxin Liu, Yan Huang, Yang Huang, Jingxiang Zhao, Zhongfang Chen, Chunyi Zhi
Atomically precise understanding of componential influences is crucial for looking into the reaction mechanism and controlled synthesis of efficient electrocatalysts. Herein, by means of comprehensive experimental and theoretical studies, we carefully examine the effects of component dopants on the catalytic performance of graphitic C3N4 (g-C3N4)-based electrocatalysts. The g-C3N4 monoliths with three types of dopant elements (B, P, and S) embedded in different sites (either C or N) of the C-N skeleton are rationally designed and synthesized...
June 15, 2017: ACS Nano
https://www.readbyqxmd.com/read/28597467/development-of-indicators-for-evaluating-the-appropriate-use-of-triazoles-for-invasive-fungal-disease-a-delphi-panel-survey
#18
W H Dong, G Z Zhang, J X Li, Y Wang, T T Wang, Y L Dong
WHAT IS KNOWN AND OBJECTIVES: Triazoles including fluconazole, itraconazole, voriconazole and posaconazole are now widely used, whereas in some countries, they are reportedly used in inappropriate way frequently; thus, it is clearly a matter of urgency to regulate the use of triazole drugs. Several studies have made good attempts to evaluate antifungal use, but they did not cover the entire medication process. This study aimed to establish indicators for the appropriate use of triazoles for invasive fungal disease, so as to produce a reference for evaluating and standardizing the rational application of triazole antifungals...
June 8, 2017: Journal of Clinical Pharmacy and Therapeutics
https://www.readbyqxmd.com/read/28596150/pain-improvement-with-novel-combination-analgesic-regimens-pain-care-randomized-controlled-trial-protocol
#19
Ian Gilron, Dongsheng Tu, Ronald Holden, Alan C Jackson, Nader Ghasemlou, Scott Duggan, Elizabeth Vandenkerkhof, Roumen Milev
BACKGROUND: Neuropathic pain (NP) (including painful diabetic neuropathy, postherpetic neuralgia, etc) affects approximately 7% to 8% of the population and is associated with a devastating symptom burden as well as a profound economic impact for patients, their families, and the health care system. Current therapies have limited efficacy and dose-limiting adverse effects (AEs). Rational combination therapy with carefully selected NP drugs has shown potential for measurable improvements in pain relief, quality of life, and health care use...
June 8, 2017: JMIR Research Protocols
https://www.readbyqxmd.com/read/28593204/steering-patchy-particles-using-multivalent-electrolytes
#20
Alexei I Abrikosov, Björn Stenqvist, Mikael Lund
Proteins and many recently designed colloids can be regarded as patchy particles where directional interactions strongly influence and govern assembly behavior. Using explicit ion implicit solvent Metropolis Monte Carlo simulations, we investigate spherical model particles, carrying both charge and electric patches, in dilute aqueous 1 : 1, 1 : 3, and 3 : 1 electrolyte solutions. Striking differences in pair interaction free energies and orientational correlations are induced by three different salts which are discussed and rationalized in terms of ion-binding to surface groups, ion-ion correlations, and double layer forces...
June 8, 2017: Soft Matter
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