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Oxidised cellulose

Mayur R Joshi, Jacqueline Latham, Gabriel Okorogheye
BACKGROUND: Flowable haemostatic agents have been shown to be superior to non-flowable agents in terms of haemostatic control and need for transfusion products in patients undergoing cardiac surgery. We investigated the economic impact of the use of a flowable haemostatic agent (Floseal) compared with non-flowable oxidised regenerated cellulose (ORC) agent in primary elective cardiac surgery from the perspective of the UK National Health Service (NHS). METHODS: A cost-consequence framework based upon clinical data from a prospective trial and an observational trial and NHS-specific actual reference costs (2016) was developed to compare the economic impact of Floseal with that of ORC...
November 29, 2017: Journal of Cardiothoracic Surgery
Llyza Mendoza, Warren Batchelor, Rico F Tabor, Gil Garnier
HYPOTHESIS: Nanocellulose gels form a new category of sustainable soft materials of industrial interest for a wide range of applications. There is a need to map the rheological properties and understand the mechanism which provides the colloidal stability and gelation of these nanofibre suspensions. EXPERIMENTS: TEMPO (2,2,6,6,-tetramethylpiperidine-1-oxyl)-oxidised cellulose nanofibre gels were investigated at different fibre concentrations, pH and ionic strength...
September 1, 2017: Journal of Colloid and Interface Science
Xuehai Xie, Agoub A Agoub, Edwin R Morris
MDOC comprises small, essentially insoluble, particles which associate to form "weak gel" networks at concentrations above ∼4wt%. Association is promoted by guar gum, causing an increase in G' at low levels of addition and a decrease at higher concentrations, due to excessive aggregation of the MDOC particles. For guar gum samples with molecular weights ranging from ∼60 to ∼1800kDa, we found that the concentration required to give maximum G' for 5wt% dispersions of MDOC increased systematically from ∼0...
August 1, 2017: Carbohydrate Polymers
Ana Balea, M Concepción Monte, Elena de la Fuente, Carlos Negro, Ángeles Blanco
Water-based or flexographic inks in paper and plastic industries are more environmentally favourable than organic solvent-based inks. However, their use also creates new challenges because they remain dissolved in water and alter the recycling process. Conventional deinking technologies such as flotation processes do not effectively remove them. Adsorption, coagulation/flocculation, biological and membrane processes are either expensive or have negative health impacts, making the development of alternative methods necessary...
February 2017: Environmental Science and Pollution Research International
Michael M H Graf, Sandra Weber, Daniel Kracher, Roman Kittl, Christoph Sygmund, Roland Ludwig, Clemens Peterbauer, Dietmar Haltrich
Multigenicity is commonly found in fungal enzyme systems, with the purpose of functional compensation upon deficiency of one of its members or leading to enzyme isoforms with new functionalities through gene diversification. Three genes of the flavin-dependent glucose-methanol-choline (GMC) oxidoreductase pyranose dehydrogenase (AmPDH) were previously identified in the litter-degrading fungus Agaricus (Leucoagaricus) meleagris, of which only AmPDH1 was successfully expressed and characterized. The aim of this work was to study the biophysical and biochemical properties of AmPDH2 and AmPDH3 and compare them with those of AmPDH1...
April 2017: Applied Microbiology and Biotechnology
Kirsten M Pondman, Basudev Paudyal, Robert B Sim, Anuvinder Kaur, Lubna Kouser, Anthony G Tsolaki, Lucy A Jones, Carolina Salvador-Morales, Haseeb A Khan, Bennie Ten Haken, Gudrun Stenbeck, Uday Kishore
Carbon nanotubes (CNTs) are increasingly being developed for use in biomedical applications, including drug delivery. One of the most promising applications under evaluation is in treating pulmonary diseases such as tuberculosis. Once inhaled or administered, the nanoparticles are likely to be recognised by innate immune molecules in the lungs such as hydrophilic pulmonary surfactant proteins. Here, we set out to examine the interaction between surfactant protein D (SP-D), a key lung pattern recognition molecule and CNTs, and possible downstream effects on the immune response via macrophages...
January 19, 2017: Nanoscale
C Wiegand, B A Buhren, E Bünemann, H Schrumpf, B Homey, R G Frykberg, F Lurie, P A Gerber
OBJECTIVE: Chronic hard-to-heal wounds generate high costs and resource use in western health systems and are the focus of intense efforts to improve healing outcomes. Here, we introduce a novel native collagen (90 %):alginate (10 %) wound dressing and compare it with the established oxidised dressings Method: Matrices were analysed by atomic force microscopy (AMF), scanning electron microscopy (SEM), and immunoelectron microscopy for collagen types I, III and V. Viability assays were performed with NIH-3T3 fibroblasts...
December 2, 2016: Journal of Wound Care
Alexander Konstantinow, Tatjana V Fischer, Johannes Ring
Split-thickness skin grafting (STSG) is a widely used method in reconstructive surgery, but donor site wounds (DSWs) are often slow healing and painful. This prospective study evaluated the performance of a composite wound dressing containing collagen/oxidised regenerated cellulose in the treatment of medium-depth (0·4 mm) DSWs in 25 multi-morbid patients with chronic leg ulcers requiring STSG. The range of patients' ages was 44-84 years (mean 71·6 years) with DSW sizes ranging between 12 and 162 cm(2) (mean 78 cm(2) )...
December 1, 2016: International Wound Journal
Rajeev Ravindran, Swarna Jaiswal, Nissreen Abu-Ghannam, Amit K Jaiswal
In the present study, novel pre-treatment for spent coffee waste (SCW) has been proposed which utilises the superior oxidising capacity of alkaline KMnO4 assisted by ultra-sonication. The pre-treatment was conducted for different exposure times (10, 20, 30 and 40min) using different concentrations of KMnO4 (1, 2, 3, 4, 5%w/v) at room temperature with solid/liquid ratio of 1:10. Pretreating SCW with 4% KMnO4 and exposing it to ultrasound for 20min resulted in 98% cellulose recovery and a maximum lignin removal of 46%...
January 2017: Bioresource Technology
Elisabetta Moggia, Benjamin Rouse, Constantinos Simillis, Tianjing Li, Jessica Vaughan, Brian R Davidson, Kurinchi Selvan Gurusamy
BACKGROUND: Liver resection is a major surgery with significant mortality and morbidity. Specialists have tested various methods in attempts to limit blood loss, transfusion requirements, and morbidity during elective liver resection. These methods include different approaches (anterior versus conventional approach), use of autologous blood donation, cardiopulmonary interventions such as hypoventilation, low central venous pressure, different methods of parenchymal transection, different methods of management of the raw surface of the liver, different methods of vascular occlusion, and different pharmacological interventions...
October 31, 2016: Cochrane Database of Systematic Reviews
Shaun S Tan, M S Yeo, Ghp Lee, Msy Ho, M L Ang, W Lee, E C Cheong
INTRODUCTION Foreign bodies (FBs) in the masticator space (MS) are a unique problem because of the difficulty of accessing this deep compartment within the head and neck. In addition, MS contents include critical structures such as the internal maxillary artery (IMA) and mandibular nerve. CASE HISTORY A 39-year-old tradesman was involved in a construction accident whereby a metallic projectile from a machinery drill penetrated his left cheek. Computed tomography revealed a metallic object of dimension 1.9 ×1...
November 2016: Annals of the Royal College of Surgeons of England
Julia Catalán, Elina Rydman, Kukka Aimonen, Kati-Susanna Hannukainen, Satu Suhonen, Esa Vanhala, Carlos Moreno, Valérie Meyer, Denilson da Silva Perez, Asko Sneck, Ulla Forsström, Casper Højgaard, Martin Willemoes, Jacob R Winther, Ulla Vogel, Henrik Wolff, Harri Alenius, Kai M Savolainen, Hannu Norppa
Nanofibrillated cellulose (NFC) is a sustainable and renewable nanomaterial, with diverse potential applications in the paper and medical industries. As NFC consists of long fibres of high aspect ratio, we examined here whether TEMPO-(2,2,6,6-tetramethyl-piperidin-1-oxyl) oxidised NFC (length 300-1000nm, thickness 10-25nm), administrated by a single pharyngeal aspiration, could be genotoxic to mice, locally in the lungs or systemically in the bone marrow. Female C57Bl/6 mice were treated with four different doses of NFC (10, 40, 80 and 200 µg/mouse), and samples were collected 24h later...
January 2017: Mutagenesis
Meri J Lundahl, A Gisela Cunha, Ester Rojo, Anastassios C Papageorgiou, Lauri Rautkari, Julio C Arboleda, Orlando J Rojas
Hydrogels comprising cellulose nanofibrils (CNF) were used in the synthesis of continuous filaments via wet-spinning. Hydrogel viscosity and spinnability, as well as orientation and strength of the spun filaments, were found to be strongly affected by the osmotic pressure as determined by CNF surface charge and solid fraction in the spinning dope. The tensile strength, Young's modulus and degree of orientation (wide-angle X-ray scattering, WAXS) of filaments produced without drawing were 297 MPa, 21 GPa and 83%, respectively, which are remarkable values...
2016: Scientific Reports
Paul H Walton, Gideon J Davies
Lytic polysaccharide monooxygenases (LPMOs) are recently discovered copper-containing oxygenases. LPMOs oxidise recalcitrant polysaccharides such as chitin and cellulose, thereby making these substrates more tractable to canonical chitinase or cellulase action. As such, LPMOs are attracting much attention not only for their capacity to greatly increase the efficiency of production of cellulosic-based biofuels, but also for the new questions they pose about the mechanisms of biological oxidation of recalcitrant substrates...
April 2016: Current Opinion in Chemical Biology
Rahman Rahmanpour, Dean Rea, Shirin Jamshidi, Vilmos Fülöp, Timothy D H Bugg
A Dyp-type peroxidase enzyme from thermophilic cellulose degrader Thermobifida fusca (TfuDyP) was investigated for catalytic ability towards lignin oxidation. TfuDyP was characterised kinetically against a range of phenolic substrates, and a compound I reaction intermediate was observed via pre-steady state kinetic analysis at λmax 404 nm. TfuDyP showed reactivity towards Kraft lignin, and was found to oxidise a β-aryl ether lignin model compound, forming an oxidised dimer. A crystal structure of TfuDyP was determined, to 1...
March 15, 2016: Archives of Biochemistry and Biophysics
Vedat Yildirim, Heinz-Theo Lübbers, Ayhan Yildirim
Since the 1950s, oxidised regenerate cellulose (TABOTAMP ®) has been successfully applied for local haemostasis in intra- or postoperative bleeding complications. The scope of this medical product is large and it has found its place in oral and maxillofacial surgery. Although the application of TABOTAMP ® in medicine and dentistry is common, further complications next to the absence of the haemostatic effect may be encountered if used incorrectly. The aim of this article is an update on the proper use of TABOTAMP ®...
2015: Swiss Dental Journal
Qiaoling Zhou, Douglas G West, Golda Shelley-Fraser, Andrew R L Medford
The radiological finding of mediastinal lymph node enlargement following surgery for lung cancer often signifies locoregional recurrence. The use of oxidised cellulose haemostatic agents (OCHAs) during staging mediastinoscopy is common. We report a case of 18-fluorodeoxyglucose-avid subcarinal lymphadenopathy in a patient in whom OCHAs had been used at mediastinoscopy 5 months earlier. Histopathological examination of suspected nodal recurrence is facilitated by endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA)...
2015: Respiration; International Review of Thoracic Diseases
Oliver Kloeters, Frank Unglaub, Erik de Laat, Marjolijn van Abeelen, Dietmar Ulrich
In chronic wounds, excess levels and activity of proteases such as elastase and plasmin have been detected. Oxidised regenerated cellulose/collagen matrix (ORC/collagen matrix) has been reported to ameliorate the wound microenvironment by binding and inactivating excess proteases in wound exudates. In this study, the levels and activity of elastase and plasmin in wound exudates of pressure sore ulcers were measured to determine the beneficial effect of ORC/collagen matrix treatment compared with control treatment with a foam dressing...
December 2016: International Wound Journal
Gaity Ahmad, Helena O'Flynn, Akshay Hindocha, Andrew Watson
BACKGROUND: Pelvic adhesions can form as a result of inflammation, endometriosis or surgical trauma. During pelvic surgery, strategies to reduce pelvic adhesion formation include placing barrier agents such as oxidised regenerated cellulose, polytetrafluoroethylene or fibrin sheets between the pelvic structures. OBJECTIVES: To evaluate the effects of barrier agents used during pelvic surgery on rates of pain, live birth and postoperative adhesions in women of reproductive age...
April 30, 2015: Cochrane Database of Systematic Reviews
Akshay Hindocha, Lawrence Beere, Sofia Dias, Andrew Watson, Gaity Ahmad
BACKGROUND: Intraperitoneal adhesions are associated with considerable co-morbidity and have large financial and public health repercussions. They have secondary effects that include chronic pelvic pain, dyspareunia, subfertility and bowel obstruction. In women with adhesions, subsequent surgery is more difficult, often takes longer, and is associated with a higher complication rate (Broek 2013). The significant burden of adhesions has led to the development of several anti-adhesion agents, although there is disagreement as to their relative effectiveness...
January 6, 2015: Cochrane Database of Systematic Reviews
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