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https://www.readbyqxmd.com/read/28426387/characterization-of-bimodal-chronotype-and-its-association-with-sleep-a-population-based-study
#1
Priscila Farias Tempaku, Juliana Ramirez Arruda, Diego Robles Mazzotti, Bruno S B Gonçalves, Mário Pedrazzoli, Lia Bittencourt, Sergio Tufik
The circadian system coordinates internal events in a daily schedule to make sure that the body systems are synchronized to environmental time and internal cues. One important behavioral aspect of the circadian system is the chronotype. It is usually assessed through subjective questionnaires, being the Horne-Ostberg Morningness-Eveningness Questionnaire (MEQ) one of the most used. It classifies individuals into three major categories: morning, evening, and intermediate types. Recently, it has been hypothesized the existence of a fourth chronotype, the bimodal type, through an algorithm derived from the MEQ responses...
2017: Chronobiology International
https://www.readbyqxmd.com/read/28425402/what-is-changing-in-indications-and-treatment-of-focal-nodular-hyperplasia-of-the-liver-is-there-any-place-for-surgery
#2
Aristotelis Perrakis, Nikolaos Vassos, Robert Gru Tzmann, Roland S Croner
Focal nodular hyperplasia (FNH) is a common benign liver tumor, which occurs in the vast majority of the cases in young women. FNH represents a polyclonal lesion characterized by local vascular abnormalities and is a truly benign lesion without any potential for malignant transformation. A retrospective single institution analysis of 227 FNH patients, treated from 1990 to 2016 and a review of studies reporting surgical therapy of overall 293 patients with FNH was performed. Indications for resection with a focus on diagnostic workup, patient selection, surgical mode and operative mortality and morbidity have been analysed...
May 2017: Annals of Hepatology
https://www.readbyqxmd.com/read/28424207/a-distributed-solute-model-an-extended-two-pore-model-with-application-to-the-glomerular-sieving-of-ficoll
#3
Carl M Öberg, Joseph J Groszek, Shuvo Roy, William H Fissell, Bengt Rippe
One of the many unresolved questions regarding the permeability of the glomerular filtration barrier is the reason behind the marked difference in permeability between albumin and polysaccharide probe molecules such as Ficoll and dextran of the same molecular size. Although the differences in permeability have been mainly attributed to charge effects, we have previously shown that this would require a highly charged filtration barrier, having a charge density that is ~10 times more than that on the albumin molecule...
April 19, 2017: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/28423758/internet-of-things-in-health-trends-through-bibliometrics-and-text-mining
#4
Stathis Th Konstantinidis, Antonis Billis, Heather Wharrad, Panagiotis D Bamidis
Recently a new buzzword has slowly but surely emerged, namely the Internet of Things (IoT). The importance of IoT is identified worldwide both by organisations and governments and the scientific community with an incremental number of publications during the last few years. IoT in Health is one of the main pillars of this evolution, but limited research has been performed on future visions and trends. Thus, in this study we investigate the longitudinal trends of Internet of Things in Health through bibliometrics and use of text mining...
2017: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/28421308/an-intelligent-remote-monitoring-system-for-total-knee-arthroplasty-patients
#5
Yunus Msayib, Patrick Gaydecki, Michael Callaghan, Nicola Dale, Sheheera Ismail
For the first six weeks following total knee arthroplasty (TKA), a patient will attend an outpatient clinic typically seen twice weekly. Here, an exercise regime is performed and improvement assessed using a hand held goniometer that measures the maximum angle of knee flexion, an important metric of progress. Additionally a series of daily exercises is performed at home, recorded in a diary. This protocol has problems. Patients must attend the hospital with assistance since they are not permitted to drive for six weeks following the procedure; appointments are sometimes missed; there are occasionally not enough physiotherapy appointment available; furthermore, it is difficult to be sure that patients are compliant with their exercises at home...
June 2017: Journal of Medical Systems
https://www.readbyqxmd.com/read/28419534/endocrine-imbalance-associated-with-proteome-changes-in-diabetes
#6
Amr A Sayed, Ahmed M Alhawary, Aboalela Farag, Dina R Johar, Larry H Bernstein
The dynamics of cellular metabolism involves rapid interactions between proteins and nucleotides, proteins and proteins, proteins and mRNA, the action of miRNA, and signaling. These also involve the interactions with respect to the sulfur bond, oxygen radicals that initiate a change in conformation and a chain of events. We review a development in molecular medicine that is a very promising work in progress. We also review the current and future research methods involving mitochondria. Long-term effects of diabetes include glycation of proteins, e...
April 17, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28418404/a-pathway-linking-reward-circuitry-impulsive-sensation-seeking-and-risky-decision-making-in-young-adults-identifying-neural-markers-for-new-interventions
#7
H W Chase, J C Fournier, M A Bertocci, T Greenberg, H Aslam, R Stiffler, J Lockovich, S Graur, G Bebko, E E Forbes, M L Phillips
High trait impulsive sensation seeking (ISS) is common in 18-25-year olds, and is associated with risky decision-making and deleterious outcomes. We examined relationships among: activity in reward regions previously associated with ISS during an ISS-relevant context, uncertain reward expectancy (RE), using fMRI; ISS impulsivity and sensation-seeking subcomponents; and risky decision-making in 100, transdiagnostically recruited 18-25-year olds. ISS, anhedonia, anxiety, depression and mania were measured using self-report scales; clinician-administered scales also assessed the latter four...
April 18, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/28417931/upstreaming-and-normalizing-advance-care-planning-conversations-a-public-health-approach
#8
Maryjo Prince-Paul, Evelina DiFranco
As a society, we simply don't talk about this universal experience called dying and death; in fact, we ignore it until we have to face it. Thus, it is often in a crisis experience when we have to make decisions while we are laden with uncertainty and intense emotions. Sixty percent of people say making sure their family is not burdened by tough decisions is extremely important, yet 56% of them have not held a conversation about its context. Instead of waiting to make end-of-life decisions, let us begin to think about what matters most while we are living, what we value most, and how we translate these values into conversations about what is important...
April 12, 2017: Behavioral Sciences
https://www.readbyqxmd.com/read/28413736/targeted-intraspinal-radiofrequency-ablation-for-lumbar-spinal-stenosis
#9
Robert E Jacobson, Michelle Granville, Jesse Hatgis DO
INTRODUCTION: By using a combination of magnetic resonance imaging (MRI) and computed tomography (CT) of the lumbar spine, it is possible to distinguish between spinal stenosis caused by bone compression and specific soft tissue epidural intraspinal lesions that cause localized spinal canal stenosis and neural compression. Examples include facet cysts and yellow ligament hypertrophy. Many of these patients are elderly with medical comorbidities that make open surgery problematic. MATERIALS & METHODS: This is a study of patients with predominantly soft tissue stenosis being treated with targeted intraspinal radiofrequency (RF) heat ablation...
March 10, 2017: Curēus
https://www.readbyqxmd.com/read/28409441/isolated-rectal-cancer-surgery-a-2007-2014-population-study-based-on-a-large-administrative-database
#10
Mario Saia, Alessandra Buja, Domenico Mantoan, Gino Sartor, Ferdinando Agresta, Vincenzo Baldo
Rectal resection is technically one of the most demanding laparoscopic procedures, requiring additional training and expertise of both surgeons and institutions. The literature has shown that laparoscopic procedures can be appropriate for the treatment of rectal cancer (RC), in terms of safety, outcome and efficiency, but results may not always be directly transferable to the general population. This study aimed to investigate the use of laparoscopic rectal cancer resections in a north-eastern Italian region (the Veneto) and to see how the characteristics of patients and hospitals are associated with the use of laparoscopy...
April 13, 2017: Updates in Surgery
https://www.readbyqxmd.com/read/28409049/rivastigmine-as-a-symptomatic-treatment-for-apathy-in-parkinson-s-dementia-complex-new-aspects-for-this-riddle
#11
Rita Moretti, Paola Caruso, Matteo Dal Ben
Over 90% of PDD patients show at least one neuropsychiatric symptom (NPS); in the 60-70% two or more NPS are present. Their incidence is important in terms of prognosis and severity of pathology. However, among all NPS, apathy is often the most disturbing, associated with greater caregiver's burden. Similar to other NPS, apathy may be due to a dysfunction of the nigrostriatal pathway, even though, not all the PD patients become apathetic, indicating that apathy should not entirely be considered a dopamine-dependent syndrome, and in fact it might also be related to acetylcholine defects...
2017: Parkinson's Disease
https://www.readbyqxmd.com/read/28408854/control-of-confounding-in-the-analysis-phase-an-overview-for-clinicians
#12
Johnny Kahlert, Sigrid Bjerge Gribsholt, Henrik Gammelager, Olaf M Dekkers, George Luta
In observational studies, control of confounding can be done in the design and analysis phases. Using examples from large health care database studies, this article provides the clinicians with an overview of standard methods in the analysis phase, such as stratification, standardization, multivariable regression analysis and propensity score (PS) methods, together with the more advanced high-dimensional propensity score (HD-PS) method. We describe the progression from simple stratification confined to the inclusion of a few potential confounders to complex modeling procedures such as the HD-PS approach by which hundreds of potential confounders are extracted from large health care databases...
2017: Clinical Epidemiology
https://www.readbyqxmd.com/read/28405032/regulatory-requirements-for-clinical-trials-in-india-what-academicians-need-to-know
#13
Nithya J Gogtay, Renju Ravi, Urmila M Thatte
The academician forms the backbone of any medical college, hospital or university and shoulders the quadruple responsibilities of patient care, teaching, administration and research. Of these, research, though long and difficult, is extremely fulfilling. Academicians often carry out research that is based on observations in practice or in response to their patient's needs. These are called as "Investigator- initiated studies" and these may not have the funding support of the pharmaceutical industry. Hence, the investigator must make sure that he/she complies with the country's regulatory requirements...
March 2017: Indian Journal of Anaesthesia
https://www.readbyqxmd.com/read/28394553/drug-induced-oral-ulcerations-case-report
#14
Vanja Vučičević Boras, Snježana Židovec-Lepej, Branka Marinović, Sven Seiwerth, Ivana Škrinjar, Dražen Pulanić, Danica Vidović Juras
A 70-year-old patient was admitted to the Department of Oral Medicine for multiple oral ulcerations on the left buccal mucosa, around 0.5 cm in diameter, as well as on the gingiva. Otherwise, the patient suffered from chronic lymphocytic leukemia, hypogammaglobulinemia, chronic renal insufficiency, with complete afunction of the right kidney, asthma, hypertension, gastritis and prostate hyperplasia. Differential diagnosis of oral ulcerations included drug induced oral ulcerations, paraneoplastic pemphigus, viral ulcerations (cytomegalovirus, herpes simplex viruses), fungal ulcerations (candidiasis, aspergillosis, histoplasmosis, cryptococcosis) and bacterial ulcerations, as well as neutropenic ulcers...
June 2016: Acta Clinica Croatica
https://www.readbyqxmd.com/read/28391106/near-infrared-light-mediated-dox-ucnps-mhtio2-nanocomposite-for-chemo-photodynamic-therapy-and-imaging
#15
Yuhua Chen, Huiming Lin, Ruihan Tong, Na An, Fengyu Qu
Recently, incorporating multiple components into one nanoplatform for anticancer theranostics has attracted most attention. Herein, a rattle-structured nanocomposite by using UCNPs (NaYF4:Yb,Tm@NaYF4) as core coated with hollow mesoporous TiO2 (UCNPs@mHTiO2) was constructed as the nanocarrier. First, UCNPs@SiO2@TiO2 was prepared, by a selective etching method to remove SiO2 shell, to make sure the hollow mesoporous structure and high surface area (347m(2)g(-1)) of UCNPs@mHTiO2. Under near-infrared (NIR) light irradiation, the UV emission can excite TiO2 to produce ROS and to realize photodynamic therapy (PDT)...
March 18, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28391022/reliable-the-value-of-early-postoperative-magnetic-resonance-imaging-after-ccm-surgery
#16
Bixia Chen, Sophia Göricke, Karsten Wrede, Ramazan Jabbarli, Max Jaegersberg, Ulrich Sure, Philipp Dammann
BACKGROUND: Cerebral cavernous malformations (CCM) can cause intracerebral hemorrhage. The lesions themselves are frequently associated with perifocal hemosiderin deposits due to repetitive microhemorrhages. Main indications for a surgical treatment are recurrent symptomatic hemorrhages or cavernoma-related epilepsy (CRE). After surgical resection, follow-up MR-imaging is usually performed to confirm a) the complete resection of the CCM and, especially in cases of CRE, b) the complete resection of the hemosiderin deposits...
April 5, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28378675/student-life-student-to-newly-qualified-nurse-make-a-checklist
#17
Jessica Ross
It is natural to feel nervous and apprehensive on your first day in uniform, but hopefully you will also feel excited. Your first day is a celebration of all the hard-won achievements throughout your training, so here are a few tips to help you make the most of it: » Organise a ward induction beforehand, or have a look around. Knowing where you are going and what your workplace looks like can help quell your nerves. » Running around trying to find a pair of scrubs to wear during handover is not ideal, so see if you can get your uniform in advance...
April 5, 2017: Nursing Standard
https://www.readbyqxmd.com/read/28378664/make-sure-your-cv-works-hard-in-marketing-you
#18
Julie Watkins
A good CV presents your skills, experience and knowledge in the best light to a potential employer.
April 5, 2017: Nursing Standard
https://www.readbyqxmd.com/read/28377660/comprehensive-format-of-informed-consent-in-research-and-practice-a-tool-to-uphold-the-ethical-and-moral-standards
#19
REVIEW
P Arun Bhupathi, G R Ravi
Informed consent in research, clinical trial, and practice is a process in which a patient/participant consents to participate or undergo the proposed procedures after being informed of its procedures, risks, and benefits. Ideally, the patient/participant is expected to give his consent only after fully comprehending the information about the procedures, benefits, and risks involved in research/clinical trial/practice. Thus, many ethical issues are entwined in the process of obtaining a proper informed consent...
January 2017: International Journal of Clinical Pediatric Dentistry
https://www.readbyqxmd.com/read/28374796/identification-of-novel-mage-g1-interacting-partners-in-retinoic-acid-induced-p19-neuronal-differentiation-using-silac-based-proteomics
#20
Yong Liu, Yujian Chen, Shide Lin, Shuguang Yang, Shaojun Liu
MAGE-G1 is a protein plays role in the early process of neurogenesis. However, the fundamental roles MAGE-G1 played in neurogenesis have not yet been completely understood. Finding the partners MAGE-G1 interacting with will surely contribute to the function study of MAGE-G1. In this study, using Stable Isotope Labeling by Amino acids in Cell culture-immunoprecipitation quantitative proteomics, we screened the interacting proteins of MAGE-G1 during retinoic acid -induced neuronal differentiation of P19 cells and firstly found that FSCN1 and VIME were potential novel MAGE-G1-interacting proteins...
April 4, 2017: Scientific Reports
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