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https://www.readbyqxmd.com/read/28545776/probabilistic-derivation-of-the-interspecies-assessment-factor-for-skin-sensitization
#1
W Bil, A G Schuur, J Ezendam, B G H Bokkers
An interspecies sensitization assessment factor (SAF) is used in the quantitative risk assessment (QRA) for skin sensitization when a murine-based NESIL (No Expected Sensitization Induction Level) is taken as point of departure. Several studies showed that, on average, the murine sensitization threshold is in good correspondence with that determined in humans. However, on an individual level, the murine and human sensitization thresholds may differ considerably. In this study, the interspecies SAF was quantified by using a probabilistic approach, to be able to take these cases into account...
May 22, 2017: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/28545519/staff-s-normative-attitudes-towards-coercion-the-role-of-moral-doubt-and-professional-context-a-cross-sectional-survey-study
#2
Bert Molewijk, Almar Kok, Tonje Husum, Reidar Pedersen, Olaf Aasland
BACKGROUND: The use of coercion is morally problematic and requires an ongoing critical reflection. We wondered if not knowing or being uncertain whether coercion is morally right or justified (i.e. experiencing moral doubt) is related to professionals' normative attitudes regarding the use of coercion. METHODS: This paper describes an explorative statistical analysis based on a cross-sectional survey across seven wards in three Norwegian mental health care institutions...
May 25, 2017: BMC Medical Ethics
https://www.readbyqxmd.com/read/28543421/foreign-relations
#3
Alejandro De La Hoz, Eduardo Díaz, Max Moses Feinstein
In a large Colombian teaching hospital, a fifty-five-year-old woman complaining of stomach pain is examined by a foreign-exchange medical student from the United States. Speaking in Spanish, the student elicits a medical history that suggests a possible recurrence of gallstones, but nothing further. Upon discussing the patient's case in private with the attending physician, the student is shocked to learn that the patient is suffering from terminal, metastatic gastric cancer but is unaware of her diagnosis...
May 2017: Hastings Center Report
https://www.readbyqxmd.com/read/28540675/viral-micrornas-host-micrornas-regulating-viruses-and-bacterial-microrna-like-rnas
#4
Sara-Elizabeth Cardin, Glen M Borchert
As masters of genome-wide regulation, miRNAs represent a key component in the complex architecture of cellular processes. Over the last decade, it has become increasingly apparent that miRNAs have many important roles in the development of disease and cancer. Recently, however, their role in viral and bacterial gene regulation as well as host gene regulation during disease progression has become a field of interest. Due to their small size, miRNAs are the ideal mechanism for bacteria and viruses that have limited room in their genomes, as a single miRNA can target up to ~30 genes...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28539300/-clinical-outcomes-of-intravascular-ultrasound-in-guiding-the-treatment-of-non-left-main-intermediate-coronary-lesions-for-patients-with-acute-coronary-syndrome
#5
Hong-Bin Liang, Qian Guo, Xin-Lu Zhang, Xue-Wei Liu, Yong-Zhen Tang, Wei-Yu Chen, Yu-Qing Hou, Jian-Cheng Xiu
OBJECTIVE: To evaluate the long-term clinical outcomes of intravascular ultrasound(IVUS) in guiding the treatment of non-left main intermediate coronary lesions for patients of acute coronary syndrome (ACS). METHODS: A total of 25 patients with intermediate coronary lesions(stenosis of 40%-70%) confirmed by coronary angiography were performed with IVUS. When MLA≥4 mm(2), we deferred the PCI treatment and performed optimal medical treatment (OMT). The patient were followed up for 12 month...
May 20, 2017: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/28537281/comprehensive-theoretical-study-of-all-1812-c60-isomers
#6
Rebecca Sure, Andreas Hansen, Peter Schwerdtfeger, Stefan Grimme
We investigate all 1812 isomers of the fullerene C60 consistently with high-accuracy quantum chemistry methods. The isomers are optimized at the PBE-D3/def2-TZVP level of theory and their relative energies are obtained at the affordable and accurate hybrid-DFT level PW6B95-D3(ATM)/def2-QZVP. For the first time reliable values for the relative energy distribution among the 1812 isomers (maximum value of 549.1 kcal mol(-1), average value of 189.8 ± 46.8 kcal mol(-1), 1267 isomers in an energy window of 150-250 kcal mol(-1)) are given...
May 24, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28534108/a-nephrologist-should-be-consulted-in-all-cases-of-acute-kidney-injury-in-the-icu-we-are-not-sure
#7
EDITORIAL
Miet Schetz, Matthieu Legrand
No abstract text is available yet for this article.
May 22, 2017: Intensive Care Medicine
https://www.readbyqxmd.com/read/28533532/beyond-rcts-in-public-health-policy-research-who-s-the-fairest-of-them-all
#8
Elena N Naumova
The article in this issue by O'Donnell et al stimulated my attention to the methods beyond randomized controlled trials that can help assess public health research and rank its utility in hierarchies of evidence. The future of public health policy research will surely combine computational power and the power of human ingenuity.
May 2017: Journal of Public Health Policy
https://www.readbyqxmd.com/read/28528005/attentional-load-of-walking-in-children-aged-7-12-and-in-adults
#9
Guillaume Chauvel, Estelle Palluel, Arthur Brandao, Guillaume Barbieri, Vincent Nougier, Isabelle Olivier
The amount of attentional resources necessary to walk in children, and how they evolve during childhood remains unclear. This study examined children's gait parameters in different dual-task conditions. 53 children, divided into two age groups (7-9 and 10-12 years old), and 18 adults walked on a mat in three different cognitive conditions: watching a video (video condition), listening its soundtrack (audio condition), and without any additional task (control condition). Questions were asked at the end of the video and audio conditions to make sure that participants were paying attention to the stimuli...
May 6, 2017: Gait & Posture
https://www.readbyqxmd.com/read/28527756/radiological-lumbar-stenosis-severity-predicts-worsening-sagittal-malalignment-on-full-body-standing-stereoradiographs
#10
Aaron J Buckland, Subaraman Ramchandran, Louis Day, Shay Bess, Themistocles Protopsaltis, Peter G Passias, Bassel G Diebo, Renaud Lafage, Virginie Lafage, Akhila Sure, Thomas J Errico
BACKGROUND CONTEXT: Patients with degenerative lumbar stenosis (DLS) adopt a forward flexed posture in an attempt to decompress neural elements. The relationship between sagittal alignment and severity of lumbar stenosis has not previously been studied. PURPOSE: We hypothesized that patients with increasing radiological severity of lumbar stenosis will exhibit worsening sagittal alignment. STUDY DESIGN: This is a cross-sectional study. PATIENT SAMPLE: Our sample consists of patients who have DLS...
May 17, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/28520651/laparoscopic-management-of-hepatocellular-carcinoma-a-critical-reappraisal
#11
David Fuks, Luca Aldrighetti, Long R Jiao, Go Wakabayashi, Paolo Limongelli
Following the introduction of the first laparoscopic liver resection, after ∼25 years, a critical reappraisal seems to be warranted. Liver resection represents the first choice for curing early hepatocellular carcinoma (HCC) allowing a curative chance also in selected patients with intermediate stage tumors. The criteria for liver resectability by laparoscopy remains the same for open surgery, which is oncological criteria (absence of extrahepatic tumor location; completely resectable R0 resection), anatomic (resectability of involved segment with its own blood surely and biliary drainage; absence of vascular invasion of portal or hepatic veins) and technical (possibility to leave in place a residual volume ≥40%)...
May 17, 2017: Surgical Laparoscopy, Endoscopy & Percutaneous Techniques
https://www.readbyqxmd.com/read/28513359/-innovations-in-your-specialty-award-winner-helped-save-my-life
#12
Elaine Cole
'Diane has given me strength and courage when I had nothing more than suicidal thoughts and, slowly but surely, she has helped me to piece together my life,' says Simon Peacock. 'She did this by keeping her word. She believed in me. She followed up referrals. She listened.'
May 17, 2017: Nursing Standard
https://www.readbyqxmd.com/read/28506796/from-head-to-toe-sex-and-gender-differences-in-the-treatment-of-ischemic-cerebral-disease
#13
REVIEW
Lorenzo Falsetti, Giovanna Viticchi, Laura Buratti, Clotilde Balucani, Alberto M Marra, Mauro Silvestrini
Stroke is a major cause of mortality and morbidity, particularly in the older ages. Women have a longer life expectancy and are more likely to experience stroke than men. Interestingly, the increased risk of ischemic stroke in women seems to be independent from age or classical cardiovascular risk factors. Notwithstanding the fact that stroke outcomes and survival are usually poorer in women, current evidence suggests that thrombolysis, antiplatelet and anticoagulant therapies are more beneficial in women than in men...
May 12, 2017: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/28506469/sur-la-vitesse-d-extinction-d-une-population-dans-un-environnement-al%C3%A3-atoire
#14
Nicolas Bacaër
This study focuses on the speed of extinction of a population living in a random environment that follows a continuous-time Markov chain. Each individual dies or reproduces at a rate that depends on the environment. The number of offspring during reproduction follows a given probability law that also depends on the environment. In the so-called subcritical case where the population goes for sure to extinction, there is an explicit formula for the speed of extinction. In some sense, environmental stochasticity slows down population extinction...
May 12, 2017: Comptes Rendus Biologies
https://www.readbyqxmd.com/read/28503718/photodithazine-photodynamic-effect-on-viability-of-9l-lacz-gliosarcoma-cell-line
#15
Leticia C Fontana, Juliana G Pinto, André H C Pereira, Cristina P Soares, Leandro J Raniero, Juliana Ferreira-Strixino
Even with the advances of conventional treatment techniques, the nervous system cancer prognosis is still not favorable to the patient which makes alternative therapies needed to be studied. Photodynamic therapy (PDT) is presented as a promising therapy, which employs a photosensitive (PS) agent, light wavelength suitable for the PS agent, and molecular oxygen, producing reactive oxygen species in order to induce cell death. The aim of this study is to observe the PDT action in gliosarcoma cell using a chlorin (Photodithazine, PDZ)...
May 15, 2017: Lasers in Medical Science
https://www.readbyqxmd.com/read/28503148/management-of-benign-prostatic-hyperplasia-could-dietary-polyphenols-be-an-alternative-to-existing-therapies
#16
REVIEW
Chinedum Eleazu, Kate Eleazu, Winner Kalu
The incidence of benign prostatic hyperplasia (BPH) is gradually on the increase. While conventional drugs such as the α1-adrenergic receptor antagonists and 5α-reductase inhibitors have been found to be useful in the treatment of BPH, the adverse side effects associated with their usage, have led to increased search for alternative means of managing this disease. Furthermore, although surgery has also been suggested to be a sure method, the cost and risks associated with it excludes it as a routine treatment...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28501957/molecular-analysis-reveals-hidden-diversity-in-zungaro-siluriformes-pimelodidade-a-genus-of-giant-south-american-catfish
#17
Antonio A Pires, Jorge L Ramirez, Pedro M Galetti, Waldo P Troy, Patricia D Freitas
The genus Zungaro contains some of the largest catfish in South America. Two valid species are currently recognized: Zungaro jahu, inhabiting the Paraná and Paraguay basins, and Zungaro zungaro, occurring in the Amazonas and Orinoco basins. Analysing Zungaro specimens from the Amazonas, Orinoco, Paraguay and Paraná basins, based on the sequencing of COI and D-loop, we found at least three MOTUs, indicating the existence of hidden diversity within this fish group. Considering the ecological and economic values of this fish, our results are surely welcomed for its conservation, disclosing new findings on its diversity and pointing out the necessity for a detailed taxonomic revision...
May 13, 2017: Genetica
https://www.readbyqxmd.com/read/28501516/is-dual-inhibition-of-metalloenzymes-hdac-8-and-mmp-2-a-potential-pharmacological-target-to-combat-hematological-malignancies
#18
REVIEW
Sk Abdul Amin, Nilanjan Adhikari, Tarun Jha
For the last three decades, metalloenzymes such as histone deacetylases (HDACs) and matrix metalloproteinases (MMPs) have been identified in promoting solid as well as hematological carcinogenesis. Histone deacetylase 8 (HDAC-8), a class I HDAC enzyme, may serve as 'epigenetic player' that affects in the regulation of transcription factors and alters the structure of chromosome associated with tumorigenesis. It is established that the influence of MMP-2 in invasion, metastasis and angiogenenic events of hematological malignancies may be suppressed by HDAC inhibitors through reversion-inducing-cysteine-rich protein with kazal motifs (RECK) protein...
May 10, 2017: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/28498023/physical-and-or-sexual-abuse-is-associated-with-increased-psychological-and-emotional-distress-among-transgender-women
#19
Alexandra L Kussin-Shoptaw, Jesse B Fletcher, Cathy J Reback
PURPOSE: Transgender women have consistently reported elevated rates of lifetime physical and sexual abuse. This study examined the associations between reported physical and/or sexual abuse and symptoms of psychological and emotional distress among a sample of urban, high-risk transgender women. METHODS: From June 2005 through July 2012, 99 transgender women enrolled in a Comprehensive Risk Counseling and Services program in Hollywood, CA. Seemingly unrelated regression equations (SURE) were used to simultaneously regress psychiatric symptom reports on participant sociodemographic characteristics and self-reported history of physical/sexual abuse...
May 12, 2017: LGBT Health
https://www.readbyqxmd.com/read/28497738/-osteocalcin-and-glucose-metabolism-assessment-of-human-studies
#20
Valérie Le Doan, Valérie Marcil
Osteocalcin, a protein secreted by osteoblasts, is recognized as a biomarker of bone mineralization. Besides, animal experimental studies have shown that osteocalcin could play an important role in glucose metabolism. Over the course of the last decade, this theory has been investigated in several human studies. Most of the results obtained from these reports support a positive correlation between total and undercarboxylated osteocalcin and insulin secretion/sensitivity. Studies also corroborate a reverse association with glycemic parameters such as fasting glucose and glycated hemoglobin...
April 2017: Médecine Sciences: M/S
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