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Peter G Passias, Samantha R Horn, Nicholas J Frangella, Gregory W Poorman, Dennis Vasquez-Montes, Bassel G Diebo, Cole A Bortz, Frank A Segreto, John Y Moon, Peter L Zhou, Shaleen Vira, Akhila Sure, Bryan Beaubrun, Jared C Tishelman, Subaraman Ramchandran, Cyrus M Jalai, Wesley Bronson, Charles Wang, Virginie Lafage, Aaron J Buckland, Thomas J Errico
BACKGROUND: Prior studies have built a foundation for understanding compensation in adult spinal deformity (ASD) patients using full-body stereographic assessments. These mechanisms, in relation to age-adjusted alignment targets, have yet to be fully studied. The aim of this study is to assess lower limb compensatory mechanisms of patients failing to meet age-adjusted alignment goals. METHODS: ASD patients >40 y/o with full body baseline and follow-up radiographs were included...
March 16, 2018: World Neurosurgery
Xiao-Meng Zhang, Fan Li, Bing Zhang, Xiao-Fen Chen, Jing-Zhu Piao
The common Aconitum herbs in clinical application mainly include Aconiti Radix(Chuanwu), Aconiti Kusnezoffii Radix(Caowu) and Aconiti Lateralis Radix Praeparaia(Fuzi), all of which have toxicity. Therefore, the safety of using Chinese patent drugs including Aconitum herbs has become an hot topic in clinical controversy. Based on the data-mining methods, this study explored the characteristics and causes of adverse drug reactions/events (ADR/ADE) of the Chinese patent drugs including Aconitum, in order to provide pharmacovigilance and rational drug use suggestions for clinical application...
January 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
Tina T Biss
No abstract text is available yet for this article.
March 17, 2018: Archives of Disease in Childhood
Ethan Leng, Benjamin Spilseth, Lin Zhang, Jin Jin, Joseph S Koopmeiners, Gregory J Metzger
PURPOSE: Computer-aided detection/diagnosis (CAD) of prostate cancer (PCa) on multipara-metric MRI (mpMRI) is an active area of research. In the literature, the performance of predictive models trained to detect PCa on mpMRI has typically been reported in terms of voxel-wise mea-sures such as sensitivity and specificity and/or area under the receiver operating curve (AUC).However, it is unclear whether models that score higher by these measures are actually superior.Here, we propose a novel method for lesion identification as well as novel measures that assess the quality of the detected lesions...
March 15, 2018: Medical Physics
Thomas J X Li, Christian M Reidys
In this paper, we analyze the length spectrum of rainbows in RNA secondary structures. A rainbow in a secondary structure is a maximal arc with respect to the partial order induced by nesting. We show that there is a significant gap in this length spectrum. We shall prove that there asymptotically almost surely exists a unique longest rainbow of length at least [Formula: see text] and that with high probability any other rainbow has finite length. We show that the distribution of the length of the longest rainbow converges to a discrete limit law and that, for finite k, the distribution of rainbows of length k becomes for large n a negative binomial distribution...
March 14, 2018: Bulletin of Mathematical Biology
Guo Yan-Li, Zou Yong-Gen, Xie Yi-Qing, Chen Hong, He Ming-Zhen, Lü Lai-Fu, Huang Li-Zhong, Jin Xiao-Lin
OBJECTIVE: To investigate the prevalence of major parasitic diseases and related knowledge, attitude and practice among rural residents in Liyang City, so as to provide the evidence for formulating appropriate preventive strategies and measures. METHODS: Three villages were selected from three towns as survey sites, and the residents who were above three years old and had been in the village for over six months were investigated. The Kato-Katz technique was applied to detect intestinal parasite eggs in residents' feces, and the cellophane anal swab was used to detect Enterobius vermicularis eggs among children aged 3-6 years...
September 27, 2017: Zhongguo Xue Xi Chong Bing Fang Zhi za Zhi, Chinese Journal of Schistosomiasis Control
Qiong Song, Qiu Chen, Qimin Wang, Longqiu Yang, Dongdong Lv, Guangli Jin, Jiaying Liu, Baolin Li, Xuejie Fei
BACKGROUND: Breast cancer is one of the leading causes of death in women worldwide. Fast growth is the important character of breast cancer, which makes sure the subsequent metastasize and invasion breast cancer. Golgi related genes GOLPH3 has been reported to regulate many kinds of cancers proliferation. However, its upregulator remains largely unknown. miRNA modulate gene expression by post-transcriptional repression to participate in many signaling pathway of breast cancer cell proliferation...
March 9, 2018: BMC Cancer
R J Cong, J F Liu, Y Jiang, Duolikun Dilixiati, X D Hou, L P Zheng
Objective: To explore the influence of the lower extremity abnormal alignment and the joint surface, and to explore the surgical skills. Methods: Twenty-two cases of tibial plateau Schatzker Ⅵ fracture internal fixation failure revision from January 2012 to January 2017 in Department of Orthopedics, Shanghai 10(th) Hospital.One year follow-up after initial surgery to make sure of failure.Three-dimensional CT scan, radiography, infection index, gait analysis, knee joint ROM, femur tibia angle, tibial plateau tibial shaft angle and posterior slope if tibial plateau were observed...
March 1, 2018: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
Raheel Akram, Muhammad Aizaz Ud Din, Sami Ullah Dar, Anila Arshad, Wei Liu, Zhanpeng Wu, Dezhen Wu
A hierarchical excavated iron-nitrogen codoped mesoporous carbon (Ex-FeN-MC) electrocatalyst has been successfully synthesized by pyrolysis of the unique ureidopyrimidinone containing organic precursor MAMIS by using silica as the mesoporous template and iron nitrate as the source of iron. The selected organic precursor has multifunctionalities with diverse distribution of nitrogen and oxygen species which constitute interesting features to prepare the Ex-FeN-MC electrocatalyst. The as-prepared Ex-FeN-MC material shows unexpectedly higher catalytic activities towards ORR/OER performances with an overpotential of 250 mV for OER in alkaline solution at a current density of 10 mA cm-2 , while the ORR activity is almost similar to that of commercial Pt/C...
March 12, 2018: Nanoscale
Dee Dee Wang, Thomas J Forbes, James C Lee, Marvin H Eng
Left atrial appendage occlusion (LAAO) is a rapidly evolving technology. Multi-modality imaging and understanding of left atrial appendage anatomy are sure to advance. Two-dimensional and 3-dimensional transesophageal echocardiography with fluoroscopy are the mainstay for LAAO image-guided therapy. Key to successful LAAO is an understanding of the transseptal puncture, LAAO size selection for the device-specific landing zone, and postdeployment evaluation for leak and complications. With advancements in computed tomography, there may be a greater role for intracardiac echocardiographic imaging in specific types of LAAO anatomy and devices...
April 2018: Interventional Cardiology Clinics
Kate Laver, Emmanuel Gnanamanickam, Craig Whitehead, Susan Kurrle, Megan Corlis, Julie Ratcliffe, Wendy Shulver, Maria Crotty
Objectives Health services worldwide are increasingly adopting consumer directed care approaches. Traditionally, consumer directed care models have been implemented in home care services and there is little guidance as to how to implement them in residential care. This study used a citizens' jury to elicit views of members of the public regarding consumer directed care in residential care. Methods A citizens' jury involving 12 members of the public was held over two days in July 2016, exploring the question: For people with dementia living in residential care facilities, how do we enable increased personal decision making to ensure that care is based on their needs and preferences? Jury members were recruited through a market research company and selected to be broadly representative of the general public...
January 1, 2018: Journal of Health Services Research & Policy
Diego Brancaccio, Donatella Diana, Salvatore Di Maro, Francesco Saverio Di Leva, Stefano Tomassi, Roberto Fattorusso, Luigi Russo, Stefania Scala, Anna Maria Trotta, Luigi Portella, Ettore Novellino, Luciana Marinelli, Alfonso Carotenuto
Peptides-binding G protein-coupled receptors play an important role in many pathological and physiological pathways. The assessment of the receptor-bound conformation of a peptidic ligand within a membrane receptor such as a GPCR is of outmost importance for a rational drug design of more potent analogues. In this work, we applied multiple ligand-based NMR methods to study the interaction of peptide heptamers, derived from the C-X-C Motif Chemokine 12 (CXCL12), and the C-X-C Chemokine Receptor Type 4 (CXCR4) on membranes of human T-Leukemia cells (CCRF-CEM cells)...
March 9, 2018: Journal of Medicinal Chemistry
Nicole R Fowler, C Elizabeth Shaaban, Alexia M Torke, Kathleen A Lane, Samir Saba, Amber E Barnato
Background: The decision to implant a cardiac device in a person with Alzheimer's disease or related dementia requires considering the possible trade-offs of quality of life (QOL) and quantity of life. This study measured the decision-making experience of patients with and without cognitive impairment (CI) who received a cardiac device and their family members who were involved in the decision. Methods and Results: Semi-structured interviews and questionnaires were administered with 15 patient-family member dyads...
2018: Cardiol Cardiovasc Med
Ekarat Rattarittamrong, Adisak Tantiworawit, Noppamas Kumpunya, Ornkamon Wongtagan, Ratchanoo Tongphung, Arunee Phusua, Chatree Chai-Adisaksopha, Sasinee Hantrakool, Thanawat Rattanathammethee, Lalita Norasetthada, Pimlak Charoenkwan, Suree Lekawanvijit
OBJECTIVES: The primary objective was to determine the prevalence of calreticulin (CALR) mutation in patients with non-JAK2V617F mutated essential thrombocythemia (ET). The secondary objectives were to evaluate the accuracy of CALR mutation analysis by high-resolution melting (HRM) analysis and real-time polymerase chain reaction (PCR) compared with DNA sequencing and to compare clinical characteristics of CALR mutated and JAK2V617F mutated ET. METHODS: This was a prospective cohort study involving ET patients registered at Chiang Mai University in the period September 2015-September 2017 who were aged more than 2 years, and did not harbor JAK2V617F mutation...
March 9, 2018: Hematology (Amsterdam, Netherlands)
Jessica K Pepper, Matthew C Farrelly, Kimberly A Watson
INTRODUCTION: Nicotine harms adolescent brain development and contributes to addiction. Some adolescents report using nicotine-free e-cigarettes, but the accuracy of their reporting is unclear. We explored adolescents' use of nicotine-free e-cigarettes and understanding of chemicals in e-cigarettes, including nicotine. METHODS: Using social media, we recruited 1589 US adolescents (aged 15-17) who reported past 30-day use of e-cigarettes in 2016. We assessed perceptions of the nicotine source in e-liquid and whether e-cigarette aerosol is just "water vapor...
February 10, 2018: Addictive Behaviors
Francis Mairet
Homeostasis is the capacity of living organisms to keep internal conditions regulated at a constant level, despite environmental fluctuations. Integral feedback control is known to play a key role in this behaviour. Here, I show that a feedback system involving transcriptional and post-translational regulations of the same executor protein acts as a proportional integral (PI) controller, leading to enhanced transient performances in comparison with a classical integral loop. Such a biomolecular controller-which I call a level and activity-PI controller (LA-PI)-is involved in the regulation of ammonium uptake by Escherichia coli through the transporter AmtB...
February 2018: Royal Society Open Science
Johannes Erhardt, Erwin Fuhrer, Oliver G Gruschke, Jochen Leupold, Matthias C Wapler, Jurgen Hennig, Thomas Stieglitz, Jan G Korvink
Patients suffering from neuronal degenerative diseases are increasingly being equipped with neural implants to treat symptoms or restore functions and increase their quality of life. Magnetic resonance imaging (MRI) would be the modality of choice for diagnosis and compulsory post-operative monitoring of such patients. However, interactions between the MR environment and implants pose severe health risks to the patient. Nevertheless, neural implant recipients regularly underwent MRI examinations, and adverse events were reported rarely...
March 7, 2018: Journal of Neural Engineering
Ramazan Jabbarli, Thiemo Florin Dinger, Marvin Darkwah Oppong, Daniela Pierscianek, Philipp Dammann, Karsten H Wrede, Klaus Kaier, Martin Köhrmann, Michael Forsting, Christoph Kleinschnitz, Ulrich Sure
BACKGROUND AND PURPOSE: Multiple intracranial aneurysms (MIAs) are common findings of cerebral angiographies; however, MIA prevalence varies in different patient cohorts. We sought to elucidate risk factors influencing MIA prevalence and the clinical consequences. METHODS: We systematically searched PubMed, Scopus, Embase, and Cochrane Library databases for publications before January 15, 2017, reporting MIA prevalence and risk factors. We used random-effects meta-analysis and multivariate regression analysis to assess the impacts of individual, study, and population characteristics...
March 6, 2018: Stroke; a Journal of Cerebral Circulation
Rossella Bruno, Greta Alì, Gabriella Fontanini
Malignant pleural mesothelioma (MPM) is an aggressive tumor associated with asbestos exposure. Histopathological analysis of pleural tissues is the gold standard for diagnosis; however, it can be difficult to differentiate malignant from benign pleural lesions. The purpose of this review is to describe the most important biomarkers and new diagnostic tools suggested for this differential diagnosis. There are many studies concerning the separation between MPM and benign pleural proliferations from both pleural tissues or effusions; most of them are based on the evaluation of one or few biomarkers by immunohistochemistry (IHC) or enzyme-linked immunosorbent assays (ELISAs), whereas others focused on the identification of MPM signatures given by microRNA (miRNA) or gene expression profiles as well as on the combination of molecular data and classification algorithms...
January 2018: Journal of Thoracic Disease
Timothy J Hunt
Arthroscopic rotator cuff repair in the obese patient offers functional outcomes and rates of complications comparable to those seen in nonobese patients. Future prospective studies with better methodology, as well as including larger numbers of severely obese patients with a body mass index of 40 or greater, will help to further elucidate if obesity truly affects outcomes in rotator cuff repair. In the meantime, be sure to consider admission of your obese rotator cuff repair patients.
March 2018: Arthroscopy: the Journal of Arthroscopic & related Surgery
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