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https://www.readbyqxmd.com/read/29244236/pyro-phyllobilins-elusive-chlorophyll-catabolites-lacking-a-critical-carboxylate-function-of-the-natural-chlorophylls
#1
Chengjie Li, Klaus Wurst, Joachim Berghold, Maren Podewitz, Klaus R Liedl, Bernhard Kräutler
A beta-keto ester grouping is a characteristic of ring E of the chlorophylls (Chls). Its presence has also reinforced the original identification of nonfluorescent Chl catabolites (NCCs) as colorless, amphiphilic phyllobilins (PBs). Polar NCCs were also detected in higher plants, in which a free carboxyl replaced the ring E ester group. Such NCCs are surprisingly resistant to loss of this carboxyl unit, and NCCs lacking the latter, i.e. pyro-NCCs (pyNCCs), have not been reported. Intrigued by the question of the natural occurrence of pyro-phyllobilins (pyPBs), we have prepared a representative pyNCC by decarboxylation of a natural NCC...
December 15, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29242159/an-implantable-depot-capable-of-in-situ-generation-of-micelles-to-achieve-controlled-and-targeted-tumor-chemotherapy
#2
Xiaoming Luo, Maohua Chen, Zhoujiang Chen, Songzhi Xie, Nan He, Tao Wang, Xiaohong Li
Camptothecin (CPT)-containing promicelle polymers (PMCPT) based on 4-armed poly(ethylene glycol) (PEG) were developed previously to self-assemble into folate-targeted and glutathione (GSH)-sensitive micelles (MCPT). To address severe systemic toxicity and lack of tumor specificity implicated in the intravenous administration of MCPT, a micelle-generating depot has been developed by blend electrospinning of PEG-poly(lactide) (PELA) copolymers, PMCPT and polyethylene oxide (PEO). Upon implantation of the depot onto the tumor, PMCPT are sustainably released to spontaneously form MCPT on the tumor site...
December 11, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/29241072/combined-efficacy-of-oseltamivir-isoprinosine-and-ellagic-acid-in-influenza-a-h3n2-infected-mice
#3
Elitsa L Pavlova, Lora S Simeonova, Galina A Gegova
Influenza pathogenesis comprises a complex cascade of impaired cellular processes resulting from the viral replication and exaggerated immune response accompanied by reactive oxygen species (ROS) burst and oxidative stress, destructing membranous structures and tissues. By classical virological and biochemical methods we compared and evaluated the therapeutic effects of 2.5mg/kg/day of the antiviral drug - oseltamivir (OS), 500mg/kg/day of the immune modulator - isoprinosine (IP) and 500mg/kg/day of the antioxidant agent ellagic acid (EA) with a focus on their combined activities in influenza H3N2 virus-infected mice...
December 11, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29240294/achieving-efficient-electrocatalytic-hydrogen-evolution-activity-based-on-ultrafine-and-highly-dispersed-rupx-encapsulated-in-n-p-co-doped-hollow-carbon-nanospheres
#4
Jing-Qi Chi, Wen-Kun Gao, Jia-Hui Lin, Bin Dong, Kai-Li Yan, Jun-Feng Qin, Bin Liu, Yong-Ming Chai, Chen-Guang Liu
The ultrafine RuPx nanoparticles (NPs) encapsulated in uniform N, P co-doped hollow carbon nanospheres (RuPx@NPC) have been synthesized through a facile route of using aniline-pyrrole polymer nanospheres to disperse Ru ions with followed gas phosphorization process. The as-prepared RuPx@NPC exhibits uniform core-shell hollow nanospherical structures with ultrafine RuPx NPs as core and N, P co-doped carbon (NPC) as shell. So this strategy integrates many advantages of designing hollow nanostructures, providing conductive substrate and doping non-metal element...
December 14, 2017: ChemSusChem
https://www.readbyqxmd.com/read/29240284/extracellular-matrix-stromal-vascular-fraction-gel-conditioned-medium-accelerates-wound-healing-in-a-murine-model
#5
Chengliang Deng, Yunfan He, Jingwei Feng, Ziqing Dong, Yao Yao, Hsiaopei Mok, Maohui Lin, Lu Feng
Conditioned medium (CM) is a new treatment modality in regenerative medicine and has shown a successful outcome in wound healing. We recently introduced extracellular matrix/stromal vascular fraction gel (ECM/SVF-gel), an adipose-derived stem cell and adipose native extracellular matrix-enriched product for cytotherapy. This study aimed to evaluate the effect of CM from ECM/SVF-gel (Gel-CM) on wound healing compared with the conventional CM from adipose tissue (Adi-CM) and stem cell (SVF-CM). In vitro wound healing effect of three CMs on keratinocytes and fibroblasts was evaluated in terms of proliferation property, migratory property, and extracellular matrix production...
December 14, 2017: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/29239528/quantifying-the-effect-of-air-gap-depth-and-range-shifter-thickness-on-tps-dosimetric-accuracy-in-superficial-pbs-proton-therapy
#6
Robert J Shirey, Hsinshun Terry Wu
This study quantifies the dosimetric accuracy of a commercial treatment planning system as functions of treatment depth, air gap, and range shifter thickness for superficial pencil beam scanning proton therapy treatments. The RayStation 6 pencil beam and Monte Carlo dose engines were each used to calculate the dose distributions for a single treatment plan with varying range shifter air gaps. Central axis dose values extracted from each of the calculated plans were compared to dose values measured with a calibrated PTW Markus chamber at various depths in RW3 solid water...
December 14, 2017: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/29239451/metal-polymer-interface-influences-apparent-electrical-properties-of-nano-structured-polyaniline-films
#7
John R Aggas, William Harrell, Jodie Lutkenhaus, Anthony Guiseppi-Elie
The interface between the conductive polymer, polyaniline (PAn-Cl), and gold, platinum, or an interceding layer of electrodeposited platinum on gold or platinum, markedly influences the apparent electrical properties and the electronic to ionic transition in physiological buffers. Polyester-supported, sputter-deposited gold and platinum thin films were laser patterned to yield co-planar Thin Film Electrodes (TFEs) suitable for platinization and deposition of PAn-Cl nanofibers. Electrodeposition of platinum from chloroplatinic acid (50 mC cm-2) onto gold produced larger feature sizes and larger surface roughness (23...
December 14, 2017: Nanoscale
https://www.readbyqxmd.com/read/29239219/multifunctional-redox-responsive-and-cd44-receptor-targeting-polymer-drug-nanomedicine-based-curcumin-and-alendronate-synthesis-characterization-and-in-vitro-evaluation
#8
Xue Dong, Shaohua Zou, Chunjing Guo, Kaili Wang, Feng Zhao, Huaying Fan, Jungang Yin, Daquan Chen
The traditional therapy of cancer has systemic side effects, and many cancers, such as human breast cancer and lung cancer easily metastasize to bones, leading to the formation of secondary tumours. This study was aimed at enhancing the anti-tumour effect of curcumin (CUR) and preventing tumour spread to the bone. A novel multifunctional redox-responsive and CD44 receptor targeting polymer-drug, poly alendronate-hyaluronan-S-S-curcumin copolymer (ALN-oHA-S-S-CUR) based CUR and alendronate (ALN) were synthesized successfully with the disulphide bond linker...
December 14, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/29238372/transplantation-of-rat-mesenchymal-stem-cells-overexpressing-hypoxia-inducible-factor-2%C3%AE-improves-blood-perfusion-and-arteriogenesis-in-a-rat-hindlimb-ischemia-model
#9
Weifeng Lu, Xiaoli Chen, Yi Si, Shichai Hong, Zhengyu Shi, Weiguo Fu
Mesenchymal stem cells (MSCs) have been increasingly tested in cell-based therapy to treat numerous diseases. Genetic modification to improve MSC behavior may enhance posttransplantation outcome. This study aims to test the potential therapeutic benefits of rat bone marrow MSCs overexpressing hypoxia-inducible factor 2α (rMSCsHIF-2α ) in a rat hindlimb ischemia model. PBS, rMSCs, or rMSCsHIF-2α were injected into rat ischemic hindlimb. Compared with the injection of PBS or rMSCs, transplantation of rMSCsHIF-2α significantly improved blood perfusion, increased the number of vessel branches in the muscle of the ischemic hindlimb, and improved the foot mobility of the ischemic hindlimb (all P < 0...
2017: Stem Cells International
https://www.readbyqxmd.com/read/29238328/impact-of-aerosol-dust-on-xmap-multiplex-detection-of-different-class-pathogens
#10
Denis A Kleymenov, Vladimir A Gushchin, Alexander L Gintsburg, Artem P Tkachuk
Environmental or city-scale bioaerosol surveillance can provide additional value for biodefense and public health. Efficient bioaerosol monitoring should rely on multiplex systems capable of detecting a wide range of biologically hazardous components potentially present in air (bacteria, viruses, toxins and allergens). xMAP technology from LuminexTM allows multiplex bead-based detection of antigens or nucleic acids, but its use for simultaneous detection of different classes of pathogens (bacteria, virus, toxin) is questionable...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29236588/topical-glycyrrhizin-is-therapeutic-for-pseudomonas-aeruginosa-keratitis
#11
Sandamali A Ekanayaka, Sharon A McClellan, Ronald P Barrett, Linda D Hazlett
PURPOSE: Glycyrrhizin (GLY), an inhibitor of high-mobility group box 1 (HMGB1) protects prophylactically against Pseudomonas aeruginosa keratitis. However, the therapeutic potential of GLY to enhance an antibiotic has not been tested and is our purpose. METHODS: C57BL/6 mice (B6) were infected with a clinical isolate (KEI 1025) of P. aeruginosa and treated topically at 6 h postinfection (p.i.) with GLY or phosphate-buffered saline (PBS). Clinical scores, photography with a slit lamp, enzyme-linked immunosorbent assay, myeloperoxidase assay, bacterial plate counts, histopathology, reactive oxygen/nitrogen species (ROS/RNS) assays, and in vitro macrophage (Mφ) stimulation assays were used to assess effects of GLY treatment...
December 13, 2017: Journal of Ocular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29236544/gene-therapy-for-cystic-fibrosis-improved-delivery-techniques-and-conditioning-with-lysophosphatidylcholine-enhance-lentiviral-gene-transfer-in-mouse-lung-airways
#12
Patricia Cmielewski, Nigel Farrow, Sharnna Devereux, David Parsons, Martin Donnelley
Purpose/Aim: Cystic fibrosis (CF) is the most common, fatal recessive genetic disease among the Caucasian population. Gene therapy has the potential to treat CF long term, however physiological barriers can prevent VSV-G pseudotyped lentiviral (LV) vectors from efficiently accessing the relevant receptors on the basolateral membrane of airway epithelial cells. The aims of this experiment were to use our new dose delivery techniques to determine whether conditioning the mouse lung conducting airways with lysophosphatidylcholine (LPC) improves the level of airway gene expression...
December 13, 2017: Experimental Lung Research
https://www.readbyqxmd.com/read/29236088/dicationic-imidazolium-based-ionic-liquid-coatings-on-zirconia-surfaces-physico-chemical-and-biological-characterization
#13
Pavan P K Sandhu, Izabelle M Gindri, Danyal A Siddiqui, Danieli C Rodrigues
In the present work, dicationic imidazolium-based ionic liquids (ILs) were investigated as multi-functional coatings on a zirconia (ZrO₂) surface to prevent biofilm formation and enhance the wear performance of zirconia while maintaining the material's compatibility with host cells. ILs containing phenylalanine and methionine were synthesized and deposited on zirconia. Intermolecular interactions driving IL deposition on zirconia were studied using X-ray photoelectron spectroscopy (XPS). Anti-biofilm activity and cell compatibility were evaluated in vitro after one and seven days, and wear performance was tested using a pin-on-disk apparatus...
December 13, 2017: Journal of Functional Biomaterials
https://www.readbyqxmd.com/read/29236001/optimization-analysis-of-separation-conditions-of-washed-water-containing-a-lead-complex-and-characterization-of-the-precipitation-products
#14
Wenmin Cai, Jiajun Chen, Qingwei Wang, Meng Wei
Presently, the large amount of industrial leaded wastewater creates a great challenge to both environmental governance and wastewater recycling. Lead complexes in washed water must be removed mostly before the washed water can be recycled. This paper reports the mechanism and factors of removing Pb complexes in simulated washed water by the sulfide precipitation method. The reaction time, sodium sulfide dosage, pH, and polymeric aluminum chloride (PAC) dosage were analyzed and the optimal conditions were explored...
December 2017: Water Science and Technology: a Journal of the International Association on Water Pollution Research
https://www.readbyqxmd.com/read/29235238/study-of-the-controlled-assembly-of-dna-gated-pei-chitosan-sio2-fluorescent-sensor
#15
Zheng Chang, Yinghao Mi, Xingwang Zheng
In this paper, polyethylenimine (PEI) and Chitosan were simultaneously one-step doped into silicon dioxide (SiO2 ) nanoparticles to synthesize PEI/Chitosan/SiO2 composite nanoparticles. The polymer PEI contained a large amount of amino groups, which can realize the amino functionalized SiO2 nanoparticles. And, the good pore forming effect of Chitosan was introduced into SiO2 nanoparticles, and the resulting composite nanoparticles also had a porous structure. In pH 7.4 phosphate buffer solution (PBS), the amino groups of PEI had positive charges, and therefore the fluorescein sodium dye molecule can be loaded into the channels of PEI/Chitosan/SiO2 composite nanoparticles by electrostatic adsorption...
December 12, 2017: Luminescence: the Journal of Biological and Chemical Luminescence
https://www.readbyqxmd.com/read/29234046/broadband-light-trapping-strategies-for-quantum-dot-photovoltaic-cells-10-and-their-issues-with-the-measurement-of-photovoltaic-characteristics
#16
Changsoon Cho, Jung Hoon Song, Changjo Kim, Sohee Jeong, Jung-Yong Lee
Bandgap tunability and broadband absorption make quantum-dot (QD) photovoltaic cells (PVs) a promising candidate for future solar energy conversion systems. Approaches to improving the electrical properties of the active layer increase efficiency in part. The present study focuses on optical room for enhancement in QD PVs over wide spectrum in the near-infrared (NIR) region. We find that ray-optical light trapping schemes rather than the nanophotonics approach may be the best solution for enhancing broadband QD PVs by suppressing the escape probability of internal photons without spectral dependency...
December 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29233904/autologous-dendritic-cells-pulsed-with-allogeneic-tumor-cell-lysate-in-mesothelioma-from-mouse-to-human
#17
Joachim G Aerts, Pauline L de Goeje, Robin Cornelissen, Margaretha E H Kaijen-Lambers, Koen Bezemer, Cor van der Leest, Niken M Mahaweni, Andre Kunert, Ferry A L M Eskens, Cynthia Waasdorp, Eric Braakman, Bronno van der Holt, Arnold G Vulto, Rudi W Hendriks, Joost P J J Hegmans, Henk C Hoogsteden
PURPOSE: Mesothelioma has been regarded as a non-immunogenic tumor, which is also shown by the low response rates to treatments targeting the PD-1/PD-L1 axis.  Previously, we demonstrated that autologous tumor lysate-pulsed dendritic cell (DC) immunotherapy increased T-cell response towards malignant mesothelioma. However, the use of autologous tumor material hampers implementation in large clinical trials, which might be overcome by using allogeneic tumor cell lines as tumor antigen source...
December 12, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29232871/thin-film-quantum-dot-photodiode-for-monolithic-infrared-image-sensors
#18
Pawel E Malinowski, Epimitheas Georgitzikis, Jorick Maes, Ioanna Vamvaka, Fortunato Frazzica, Jan Van Olmen, Piet De Moor, Paul Heremans, Zeger Hens, David Cheyns
Imaging in the infrared wavelength range has been fundamental in scientific, military and surveillance applications. Currently, it is a crucial enabler of new industries such as autonomous mobility (for obstacle detection), augmented reality (for eye tracking) and biometrics. Ubiquitous deployment of infrared cameras (on a scale similar to visible cameras) is however prevented by high manufacturing cost and low resolution related to the need of using image sensors based on flip-chip hybridization. One way to enable monolithic integration is by replacing expensive, small-scale III-V-based detector chips with narrow bandgap thin-films compatible with 8- and 12-inch full-wafer processing...
December 10, 2017: Sensors
https://www.readbyqxmd.com/read/29232418/nano-emulsions-as-vehicles-for-topical-delivery-of-forskolin
#19
Małgorzata Miastkowska, Elżbieta Sikora, Elwira Lasoń, Maria Jose Garcia-Celma, Elvira Escribano-Ferrer, Conxita Solans, Meritxell Llinas
Two O/W forskolin-loaded nano-emulsions (0.075% wt.) based on medium chain triglycerides (MCT) and stabilized by a nonionic surfactant (Polysorbate 80 or Polysorbate 40) were studied as forskolin delivery systems. The nano-emulsions were prepared by the PIC method. The mean droplet size of the nano-emulsions with Polysorbate 80 and Polysorbate 40 with oil/surfactant (O/S) ratios of 20/80 and 80% water concentration, measured by Dynamic Light Scattering (DLS), was of 118 nm and 111 nm, respectively. Stability of the formulations, as assessed by light backscattering for 24 h, showed that both nano-emulsions were stable at 25ºC...
December 13, 2017: Acta Biochimica Polonica
https://www.readbyqxmd.com/read/29230965/prevention-of-chemotherapy-induced-cachexia-by-acvr2b-ligand-blocking-has-different-effects-on-heart-and-skeletal-muscle
#20
Juha J Hulmi, Tuuli A Nissinen, Markus Räsänen, Joni Degerman, Juulia H Lautaoja, Karthik Amudhala Hemanthakumar, Janne T Backman, Olli Ritvos, Mika Silvennoinen, Riikka Kivelä
BACKGROUND: Toxicity of chemotherapy on skeletal muscles and the heart may significantly contribute to cancer cachexia, mortality, and decreased quality of life. Doxorubicin (DOX) is an effective cytostatic agent, which unfortunately has toxic effects on many healthy tissues. Blocking of activin receptor type IIB (ACVR2B) ligands is an often used strategy to prevent skeletal muscle loss, but its effects on the heart are relatively unknown. METHODS: The effects of DOX treatment with or without pre-treatment with soluble ACVR2B-Fc (sACVR2B-Fc) were investigated...
December 11, 2017: Journal of Cachexia, Sarcopenia and Muscle
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