Danielle M Mullis, Amanda Padilla-Lopez, Hanjay Wang, Yuanjia Zhu, Stefan Elde, Spencer A Bonham, Shin Yajima, Olivier N Kocher, Monty Krieger, Y Joseph Woo
BACKGROUND AND AIMS: There are a limited number of pharmacologic therapies for coronary artery disease, and few rodent models of occlusive coronary atherosclerosis and consequent myocardial infarction with which one can rapidly test new therapeutic approaches. Here, we characterize a novel, fertile, and easy-to-use HDL receptor (SR-B1)-based model of atherogenic diet-inducible, fatal coronary atherosclerosis, the SR-B1ΔCT/LDLR KO mouse. Additionally, we test intramyocardial injection of Stromal Cell-Derived Factor-1 alpha (SDF-1α), a potent angiogenic cytokine, as a possible therapy to rescue cardiac function in this mouse...
March 22, 2024: Atherosclerosis