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https://www.readbyqxmd.com/read/28822456/-human-umbilical-cord-mesenchymal-stem-cell-transplantation-for-the-treatment-of-two-noncontinuous-segments-spinal-cord-compression-injury-in-rabbits
#1
C H Yang, B Q Yu, Q H You, J J Feng
Objective: In order to explore the effects of human umbilical cord mesenchymal stem cells (UCMSC) transplantation on the treatment of two noncontinuous segments spinal cord compression injury and to investigate whether repeated intravenous injection UCMSC was more beneficial for the recovery of spinal cord function. Methods: A total of 30 adult rabbits were randomly divided into three groups: control group (received PBS), single injection group, repeated injection group with 3 days intervals. A noncontinuous two segments SCI model was established by using the 2F Fogarty balloon catheter...
August 8, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/28818492/-dexmedetomidine-preconditioning-protects-against-lipopolysaccharides-induced-injury-in-the-human-alveolar-epithelial-cells
#2
Lei Zhang, Xian-Jin Zhou, Li-Ying Zhan, Xiao-Jing Wu, Wen-Lan Li, Bo Zhao, Qing-Tao Meng, Zhong-Yuan Xia
BACKGROUND AND OBJECTIVES: Dexmedetomidine (DEX) has demonstrated the preconditioning effect and shown protective effects against organize injury. In this study, using A549 (human alveolar epithelial cell) cell lines, we investigated whether DEX preconditioning protected against acute lung injury (ALI) in vitro. METHODS: A549 were randomly divided into four groups (n=5): control group, DEX group, lipopolysaccharides (LPS) group, and D-LPS (DEX+LPS) group. Phosphate buffer saline (PBS) or DEX were administered...
August 14, 2017: Revista Brasileira de Anestesiologia
https://www.readbyqxmd.com/read/28818376/an-overview-on-the-strategies-to-exploit-rice-endosperm-as-production-platform-for-biopharmaceuticals
#3
REVIEW
Fumio Takaiwa, Yuhya Wakasa, Shimpei Hayashi, Taiji Kawakatsu
Cereal seed has been utilized as production platform for high-value biopharmaceutical proteins. Especially, protein bodies (PBs) in seeds are not only natural specialized storage organs of seed storage proteins (SSPs), but also suitable intracellular deposition compartment for recombinant proteins. When various recombinant proteins were produced as secretory proteins by attaching N terminal ER signal peptide and C terminal KDEL endoplasmic reticulum (ER) retention signal or as fusion proteins with SSPs, high amounts of recombinant proteins can be predominantly accumulated in the PBs...
October 2017: Plant Science: An International Journal of Experimental Plant Biology
https://www.readbyqxmd.com/read/28816159/consensus-guidelines-for-implementing-pencil-beam-scanning-proton-therapy-for-thoracic-malignancies-on-behalf-of-the-ptcog-thoracic-and-lymphoma-subcommittee
#4
REVIEW
Joe Y Chang, Xiaodong Zhang, Antje Knopf, Heng Li, Shinichiro Mori, Lei Dong, Hsiao-Ming Lu, Wei Liu, Shahed N Badiyan, Stephen Both, Arturs Meijers, Liyong Lin, Stella Flampouri, Zuofeng Li, Kikuo Umegaki, Charles B Simone, Xiaorong R Zhu
Pencil-beam scanning (PBS) proton therapy (PT), particularly intensity modulated PT, represents the latest advanced PT technology for treating cancers, including thoracic malignancies. On the basis of virtual clinical studies, PBS-PT appears to have great potential in its ability to tightly tailor the dose to the target while sparing critical structures, thereby reducing treatment-related toxicities, particularly for tumors in areas with complicated anatomy. However, implementing PBS-PT for moving targets has several additional technical challenges compared with intensity modulated photon radiation therapy or passive scattering PT...
September 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28815766/preparation-of-robust-metal-free-magnetic-nanoemulsions-encapsulating-low-molecular-weight-nitroxide-radicals-and-hydrophobic-drugs-directed-toward-mri-visible-targeted-delivery
#5
Rui Tamura, Kota Nagura, Yusa Takemoto, Satori Moronaga, Yoshiaki Uchida, Satoshi Shimono, Akihiko Shiino, Kenji Tanigaki, Tsukuru Amano, Fumi Yoshino, Yohei Noda, Satoshi Koizumi, Naoki Komatsu, Tatsuhisa Kato, Jun Yamauchi
With a view to developing a theranostic nanomedicine for magnetic resonance (MR) imaging-visible targeted drug delivery system, robust metal-free magnetic nanoemulsions (mean particle sizes of less than 20 nm) consisting of the biocompatible surfactant 1 and the incorporated hydrophobic low-molecular-weight 2,2,5-trimethyl-5-(4-alkoxy)phenylpyrrolidine-N-oxyl radicals [(±)-2] have been prepared in pH 7.4 phosphate-buffered saline. The structure of the nanoemulsions has been characterized by electron paramagnetic resonance spectroscopy, and dynamic light scattering and small angle neutron scattering measurements...
August 16, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28814403/oxidized-low-density-lipoprotein-induced-microparticles-promote-endothelial-monocyte-adhesion-via-intercellular-adhesion-molecule-1
#6
Zhiwei Fu, Enchen Zhou, Xu Wang, Mingda Tian, Jian Kong, Jizhao Li, Liang Ji, Chenguang Niu, Haitao Shen, Shuying Dong, Changjie Liu, Alphons Vermorken, Belinda Belle Willard, Lingyun Zu, Lemin Zheng
Oxidized low density lipoprotein (oxLDL) accumulates early in atherosclerotic lesions and plays an important role in the progressive formation of atherosclerotic plaques. Endothelial derived microparticles (EMPs) form a heterogeneous population of < 1μm particles that shed from endothelial membranes upon activation. While EMPs are shown to be involved in atherosclerotic pathophysiology and progression, there is no report regarding to the relationship between oxLDL and EMPs. In this study we aim to determine the influence of oxLDL on endothelial microparticle release and the subsequent regulation of the endothelial activation...
August 16, 2017: American Journal of Physiology. Cell Physiology
https://www.readbyqxmd.com/read/28813174/depressive-symptoms-and-drinking-outcomes-the-mediating-role-of-drinking-motives-and-protective-behavioral-strategies-among-college-students
#7
Margo C Villarosa, Mary Anne Messer, Michael B Madson, Virgil Zeigler-Hill
BACKGROUND: College students with depressive symptoms tend to engage in more hazardous drinking and experience more alcohol-related consequences to cope with their symptoms. Given the perceived tension reducing effects of alcohol among these students, it is important to explore how protective factors, such as protective behavioral strategies, account for the relationships among depressive symptoms, drinking motives, and alcohol-related outcomes. OBJECTIVE: To examine the mediating role of drinking motives and protective behavioral strategies on the associations that depressive symptoms have with typical weekly alcohol consumption, hazardous drinking, and alcohol-related negative consequences in a sample of college student drinkers...
August 16, 2017: Substance Use & Misuse
https://www.readbyqxmd.com/read/28812348/inhibition-of-heterogeneous-ice-nucleation-by-bioinspired-coatings-of-polyampholytes
#8
Zhiyuan He, Liuchun Zheng, Zhenqi Liu, Shenglin Jin, Chuncheng Li, Jianjun Wang
Controlling of heterogeneous ice nucleation (HIN) on foreign surfaces is of great importance for anti-ice nucleation material design. In this work, we studied the HIN behaviors on various ion-modified poly(butylene succinate) (PBS) surfaces via chain-extension reaction. Inspired by antifreeze proteins (AFPs), the PBS-based polyampholytes, containing both negative and positive charge groups on a single chain, show excellent performance of ice nucleation inhibition and freezing delay. Unlike the extremely high price and low availability of AFPs, these PBS-based polyampholytes can be commercially synthesized under mild reaction conditions...
August 16, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28808378/rutamarin-an-active-constituent-from-ruta-angustifolia-pers-induced-apoptotic-cell-death-in-the-ht29-colon-adenocarcinoma-cell-line
#9
Shafinah Ahmad Suhaimi, Sok Lai Hong, Sri Nurestri Abdul Malek
BACKGROUND: Ruta angustifolia Pers. is a perennial herb that is cultivated worldwide, including Southeast Asia, for the treatment of various diseases as traditional medicine. OBJECTIVE: The purpose of the study was to identify an active principle of R. angustifolia and to investigate its effect on the HT29 cell death. MATERIALS AND METHODS: The methanol and fractionated extracts (hexane, chloroform, ethyl acetate, and water) of R. angustifolia Pers...
July 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/28808377/anti-inflammatory-potential-of-petiveria-alliacea-on-activated-raw264-7-murine-macrophages
#10
Rosa Martha Perez Gutierrez, Carlos Hoyo-Vadillo
BACKGROUND: Defense and protection to multiple harmful stimuli are the inflammation, when is self-amplified and uncontrolled is the basis of the pathogenesis of a wide variety of inflammatory illness. The aim of this study was to evaluate if Petiveria alliacea could attenuate inflammation in a murine model of RAW264 macrophages the involved model and its involved mechanism. MATERIALS AND METHODS: The ethanol extract from P. alliacea was precipitated with water and supernatant was used for this study (PW)...
July 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/28807282/age-of-haemonchus-contortus-third-stage-infective-larvae-is-a-factor-influencing-the-in-vitro-assessment-of-anthelmintic-properties-of-tannin-containing-plant-extracts
#11
G S Castañeda-Ramírez, C Mathieu, G Vilarem, H Hoste, P Mendoza-de-Gives, P G González-Pech, J F J Torres-Acosta, C A Sandoval-Castro
The larval exsheathment inhibition assay (LEIA) of infective larvae (L3) is an in vitro method used to evaluate the anthelmintic (AH) activity of tannin-containing plant extracts against different species of gastrointestinal nematodes, including Haemonchus contortus. Some conditions remain to be defined in order to standardize the LEIA, i.e. the optimal age of larvae produced from donor animals to use in the assays. Therefore, this study aimed at identifying the effect of age and age-related vitality of H. contortus infective larvae produced under tropical conditions, on the in vitro AH activity measured with the LEIA...
August 30, 2017: Veterinary Parasitology
https://www.readbyqxmd.com/read/28806526/highly-selective-self-powered-sensing-platform-for-p-nitrophenol-detection-constructed-with-a-photocathode-based-photocatalytic-fuel-cell
#12
Kai Yan, Yaohua Yang, Yuhan Zhu, Jingdong Zhang
A photocathode-based photocatalytic fuel cell (PFC) was fabricated and proposed as a self-powered sensor for p-nitrophenol (p-NP) detection. The PFC was comprised of a photocathode and an anode in separated chambers, which could generate suitable power output under photoirradiation to drive the sensing process. In this device, p-type PbS quantum dots-modified glass carbon electrode (GCE) served as the photocathode for the reduction of p-NP under photoirradiation while graphene-modified GCE was employed as the anode for the oxidation of ascorbic acid...
August 14, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28806140/adherent-invasive-e-coli-enhances-colonic-hypersensitivity-and-p2x-receptors-expression-during-post-infectious-period
#13
Amandine Lashermes, Ludivine Boudieu, Julie Barbier, Benoit Sion, Agathe Gelot, Nicolas Barnich, Denis Ardid, Frédéric Antonio Carvalho
Irritable Bowel Syndrome (IBS) and Inflammatory Bowel Disease (IBD) are related gastrointestinal disorders characterized by abdominal pain associated with colonic hypersensitivity (CHS). Studies in humans have reported an abnormal colonization of Adherent-Invasive E. coli (AIEC) in the ileum of Crohn's disease (CD) patients associated with overexpression of the bacterial colonizing receptor CEACAM6. The aim of the present study was to investigate whether AIEC reference strain LF82 could induce intestinal impairment during infectious and/or post-infectious periods and subsequently the development of CHS...
August 14, 2017: Gut Microbes
https://www.readbyqxmd.com/read/28805872/microfluidic-co-flow-of-newtonian-and-viscoelastic-fluids-for-high-resolution-separation-of-microparticles
#14
Fei Tian, Wei Zhang, Lili Cai, Shanshan Li, Guoqing Hu, Yulong Cong, Chao Liu, Tiejun Li, Jiashu Sun
The microfluidic passive control of microparticles largely relies on the hydrodynamic effects of the carrier media such as Newtonian fluids and viscoelastic fluids. Yet the viscoelastic/Newtonian interfacial effect has been scarcely investigated, especially for high-resolution particle separation. Here we report a microfluidic co-flow of Newtonian (water or PBS) and viscoelastic fluids (PEO) for the size-dependent separation of microparticles. The co-flow condition generates a stable viscoelastic/Newtonian interface, giving rise to the wall-directed elastic lift forces that compete with the center-directed lift forces, and efficiently hinders the migration of microparticles from the Newtonian to the viscoelastic fluid in a size-dependent manner...
August 14, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/28805796/bifidobacterium-breve-as-a-delivery-vector-of-il-24-gene-therapy-for-head-and-neck-squamous-cell-carcinoma-in-vivo
#15
L Wang, I Vuletic, D Deng, W Crielaard, Z Xie, K Zhou, J Zhang, H Sun, Q Ren, C Guo
Beneficial bacteria are becoming ever more popular gene delivery method for hypoxia- tumor targeting in vivo. In this study we investigated the therapeutic effect of new recombinant Bifidobacterium breve strain expressing IL-24 gene (B.breve-IL24) on head and neck tumor xenograft in mice. Briefly, B.breve transformants were obtained through electro-transformation. Bacteria-tumor targeting ability were analyzed in vivo over different time points (1, 3 and 7 days post- bacteria injection). Furthermore, the therapeutic effect of bacteria on tumor cells in vivo were analyzed as follows: 30 Balb/c nude mice bearing subcutaneous tumor were randomly divided in three groups (Drug group, GFP group and Saline group)...
August 14, 2017: Gene Therapy
https://www.readbyqxmd.com/read/28805276/visible-light-mediated-selective-arylation-of-cysteine-in-batch-and-flow
#16
Cecilia Bottecchia, Maarten Rubens, Smita Gunnoo, Volker Hessel, Annemieke Madder, Timothy Noel
A mild visible light-mediated strategy for cysteine arylation is presented. The method relies on the use of Eosin Y as a metal-free photocatalyst and aryldiazonium salts as arylating agents. The reaction can be significantly accelerated in a microflow reactor, whilst allowing the in situ formation of the required diazonium salts. The batch and flow protocol described herein can be applied to obtain a broad series of arylated cysteine derivatives and arylated cysteine-containing dipeptides. Moreover, the method was applied to the chemoselective arylation of a model peptide in biocompatible reaction conditions (room temperature, PBS buffer) within a short reaction time...
August 14, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28805064/double-crystalline-multiblock-copolymers-with-controlling-microstructure-for-high-shape-memory-fixity-and-recovery
#17
Miaoming Huang, Liuchun Zheng, Lili Wang, Xia Dong, Xia Gao, Chuncheng Li, Dujin Wang
The shape memory performance of double crystalline poly(butylene succinate)-co-poly(ε-caprolactone) (PBS-co-PCL) multiblock copolymers with controlling microstructure was studied, and the corresponding microstructure origin was further quantitatively analyzed by wide and small angle X-ray scattering (WAXS and SAXS) experiments. It was found that the multiblock copolymer with higher PCL content, proper deformation strain and inhibited crystallization of PBS (lower crystallinity and smaller crystal size, which could be realized by quenching from the melt) would exhibit better shape memory fixity and recovery performance...
August 14, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28805063/hierarchical-porous-co9s8-nitrogen-doped-carbon-mos2-polyhedrons-as-ph-universal-electrocatalysts-for-highly-efficient-hydrogen-evolution-reaction
#18
Hongmei Li, Xing Qian, Chong Xu, Shaowei Huang, Changli Zhu, Xiancai Jiang, Li Shao, Linxi Hou
The development of highly active and stable earth-abundant electrocatalysts to reduce or eliminate the reliance on noble-metal based ones for hydrogen evolution reaction (HER) over a broad pH range remains a great challenge. Herein, hierarchical porous Co9S8/N-doped carbon@MoS2 (Co9S8/NC@MoS2) polyhedrons have been synthesized by a facile hydrothermal approach using highly conductive Co/NC polyhedrons composed of cobalt nanoparticles embedded in N-doped carbon matrices as both the structural support and cobalt source...
August 21, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28804865/value-of-the-pitt-bacteraemia-score-to-predict-short-term-mortality-in-staphylococcus-aureus-bloodstream-infection-a-validation-study
#19
Jan A Roth, Sarah Tschudin-Sutter, Marc Dangel, Reno Frei, Manuel Battegay, Andreas F Widmer
BACKGROUND AND AIMS: The widely used Pitt Bacteraemia Score (PBS) has repeatedly been described as a risk factor for short-term mortality in Staphylococcus aureus bloodstream infection (BSI), but little is known about its overall predictive performance. We therefore aimed to externally validate the PBS in S. aureus BSIs. METHODS: We performed a retrospective validation study at the University Hospital Basel. Adult patients with a first episode of methicillin-susceptible S...
August 14, 2017: Swiss Medical Weekly
https://www.readbyqxmd.com/read/28804458/induced-pluripotent-stem-cells-derived-mesenchymal-stem-cells-attenuate-cigarette-smoke-induced-cardiac-remodeling-and-dysfunction
#20
Yingmin Liang, Xiang Li, Yuelin Zhang, Sze Chun Yeung, Zhe Zhen, Mary S M Ip, Hung Fat Tse, Qizhou Lian, Judith C W Mak
The strong relationship between cigarette smoking and cardiovascular disease (CVD) has been well-documented, but the mechanisms by which smoking increases CVD risk appear to be multifactorial and incompletely understood. Mesenchymal stem cells (MSCs) are regarded as an important candidate for cell-based therapy in CVD. We hypothesized that MSCs derived from induced pluripotent stem cell (iPSC-MSCs) or bone marrow (BM-MSCs) might alleviate cigarette smoke (CS)-induced cardiac injury. This study aimed to investigate the effects of BM-MSCs or iPSC-MSCs on CS-induced changes in serum and cardiac lipid profiles, oxidative stress and inflammation as well as cardiac function in a rat model of passive smoking...
2017: Frontiers in Pharmacology
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