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https://www.readbyqxmd.com/read/29457730/cryo-spectroscopy-studies-of-intact-light-harvesting-antennas-reveal-empirical-electronic-energy-transitions-in-two-cyanobacteria-species
#1
Albert Collins Nganou Assonkeng, Noam Adir, Martin Mkandawire
Understanding of electronic energy transition (EET) mechanisms from the light-harvesting unit to the reaction centre in a natural system has been limited by; (a) the use of conventional transient time-resolved spectroscopy at room temperature, which result in high signal-to-noise ratio; and (b) examining extracts instead of intact light-harvesting units. Here, we report previously unknown differences and new insight in EET of two cyanobacteria species, Acaryochloris marina and Thermosynechoccocus vulvanus, which have been found only after using Uv-vis, hole-burning and fluorescence spectroscopy at ultra-low temperature and examining their intact light-harvesting unit, phycobilisomes (PBS)...
February 19, 2018: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/29456865/a-real-world-example-of-coverage-with-evidence-development-in-australia-ipilimumab-for-the-treatment-of-metastatic-melanoma
#2
Hansoo Kim, Samantha Comey, Karl Hausler, Greg Cook
Background: Australian Government subsidisation of ipilimumab for the treatment of patients with metastatic melanoma was conditional on the sponsor entering a 'managed entry scheme' to assess the 2-year overall survival rate in metastatic melanoma patients who received ipilimumab in the first year of Pharmaceutical Benefits Scheme listing. Methods: All unresectable stage IIIc / IV metastatic melanoma patients treated with at least one dose of ipilimumab therapy in Australia from the PBS listing date to a time point 12 months later (i...
2018: Journal of Pharmaceutical Policy and Practice
https://www.readbyqxmd.com/read/29456226/three-cases-of-prune-belly-syndrome-at-the-lagos-state-university-teaching-hospital-ikeja
#3
Adaobi U Solarin, Elizabeth A Disu, Henry O Gbelee, Adeola B Animasahaun, Oluwatosin E Aremu, Eucharia Ogbuokiri, Gbemisola O Ogunnaike, Alaba Oladimeji
Prune belly syndrome (PBS) is a rare congenital disorder affecting 2.5 to 3.8/100,000 live births worldwide. Our objective of this report is to describe clinical manifestation, laboratory, and radiological characteristics of PBS in our patients, to highlight the limitations to offering appropriate patient care due to parents demanding discharge against medical advice and the need to increase the awareness regarding this rare disease. We report three cases; all referred after birth with lax abdominal wall, congenital anomalies of kidney, and urinary tract...
January 2018: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/29455978/chitosan-adsorption-on-nanofibrillated-cellulose-with-different-aldehyde-content-and-interaction-with-phosphate-buffered-saline
#4
Sedat Ondaral, Elif Çelik, Orçun Çağlar Kurtuluş, Elif Aşıkuzun, İsmail Yakın
The chitosan adsorption on films prepared using nanofibrillated cellulose (NFC) with different content of aldehyde group was studied by means of Quartz Crystal Microbalance with Dissipation (QCM-D). Results showed that frequency change (Δf) was higher when the chitosan adsorbed on NFC film consisting more aldehyde group indicating the higher adsorption. The (Δf) and dissipation (ΔD) factors completely changed during adsorption of chitosan pre-treated with acetic acid: Δf increased and ΔD decreased, oppositely to un-treated chitosan adsorption...
April 15, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29455543/effect-of-leucine-on-nf-%C3%AE%C2%BAb-pathway-in-liver-regeneration-after-partial-hepatectomy-in-rats-as-determined-by-miniarray-analysis
#5
E Ceyhan, M Canbek, M Uyanoglu, A Ozen, B Durmus Ozen, B Berber, A Ozmen Yaylaci, L Resulzade
BACKGROUND: Although some amino acids are recognized to have favorable effects on the liver regeneration after partial hepatectomy (PH), molecular mechanisms underlying these effects are barely known. OBJECTIVE: Our study was aimed to investigate the effects of valine, glutamine, and leucine amino acids on PH-induced NF-κB signal pathway. The research team studied Leucine in a rat model in vivo. The study took place in the medical and surgical experimental research center at the Eskisehir Osmangazi University in Eskisehir, Turkey...
2018: Bratislavské Lekárske Listy
https://www.readbyqxmd.com/read/29454956/de-novo-transcriptome-assembly-and-analysis-of-differential-gene-expression-following-peptidoglycan-pgn-challenge-in-antheraea-pernyi
#6
Yu Liu, Zhao-Zhe Xin, Dai-Zhen Zhang, Xiao-Yu Zhu, Ying Wang, Li Chen, Bo-Ping Tang, Chun-Lin Zhou, Xin-Yue Chai, Ji-Wu Tian, Qiu-Ning Liu
Antheraea pernyi is not only an important economic insect, it is increasingly employed as a model organism due to a variety of advantages, including ease of rearing and experimental manipulation compared with other Lepidoptera. Peptidoglycan (PGN) is a major component of the bacterial cell wall, and interactions between PGN and A. pernyi cause a series of physiological changes in the insect. In the present study, we constructed cDNA libraries from a A. pernyi PGN-infected group and a control group stimulated with phosphate-buffered saline (PBS)...
February 15, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29454302/aerobic-exercise-inhibits-obesity-induced-respiratory-phenotype
#7
Jefferson Comin Jonco Aquino-Junior, BreAnne MacKenzie, Ana Roberta Almeida-Oliveira, Ana Carolina Martins, Manoel Carneiro Oliveira-Junior, Auriléa Aparecida Britto, Fernanda Magalhaes Arantes-Costa, Nilsa Regina Damaceno-Rodrigues, Elia Garcia Caldini, Ana Paula Ligeiro de Oliveira, Dioze Guadagnini, Luiz Osorio Leiria, Djalma Rabelo Ricardo, Mario Jose Abdalla Saad, Rodolfo Paula Vieira
PURPOSE: Obesity results in decreased lung function and increased inflammation. Moderate aerobic exercise (AE) reduced lung inflammation and remodeling in a variety of respiratory disease models. Therefore, this study investigated whether AE can attenuate a diet-induced obesity respiratory phenotype; including airway hyper-responsiveness (AHR), remodeling and inflammation. METHODS: Sixty C57Bl/6 male mice were distributed into four groups: control lean (CL), exercise lean (EL), obese (O) and obese exercise (OE) groups (2 sets of 7 and 8 mice per group; n = 15)...
February 14, 2018: Cytokine
https://www.readbyqxmd.com/read/29454300/gold-copper-bimetallic-nanoparticles-supported-on-nano-p-zeolite-modified-carbon-paste-electrode-as-an-efficient-electrocatalyst-and-sensitive-sensor-for-determination-of-hydrazine
#8
Fatemeh Amiripour, Seyed Naser Azizi, Shahram Ghasemi
In this report, a facile, efficient and low cost electrochemical sensor based on bimetallic Au-Cu nanoparticles supported on P nanozeolite modified carbon paste electrode (Au-Cu/NPZ/CPE) was constructed and its efficiency for determination of hydrazine in trace level was studied. For this purpose, agro waste material, stem sweep ash (SSA) was employed as the starting material (silica source) for the synthesis of nano P zeolite (NPZ). After characterization of the synthesized NPZ by analytical instruments (scanning electronic microscopy (SEM), transmission electron microscopy (TEM), X-ray diffraction (XRD) and Fourier transform infrared (FT-IR) spectroscopy), construction of Au-Cu/NPZ/CPE was performed by three steps procedure involving preparation of nano P zeolite modified carbon paste electrode (NPZ/CPE), introducing Cu +2 ions into nano zeolite structure by ion exchange and electrochemical reduction of Cu +2 ions upon applying constant potential...
February 5, 2018: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29453004/electrochemical-surface-enhanced-raman-scattering-measurement-on-ligand-capped-pbs-quantum-dots-at-gap-of-au-nanodimer
#9
Xiaowei Li, Hiro Minamimoto, Kei Murakoshi
The vibrational characteristics of ligand-capped lead sulfide (PbS) quantum dots (QDs) were clarified via electrochemical surface-enhanced Raman spectroscopy (EC-SERS) using a hybridized system of gold (Au) nanodimers and PbS QDs under electrochemical potential control. Enhanced electromagnetic field caused by the coupling of QDs with plasmonic Au nanodimers allowed the characteristic behavior of the ligand oleic acid (OA) on the PbS QD surface to be detected under electrochemical potential control. Binding modes between the QDs and OA molecules were characterized using synchronous two-dimensional correlation spectra at distinct electrochemical potentials, confirming that the bidentate bridging mode was probably the most stable mode even under relatively negative potential polarization...
February 7, 2018: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/29452947/highly-stable-molybdenum-dioxide-nanoparticles-with-strong-plasmon-resonance-are-promising-in-photothermal-cancer-therapy
#10
Wei Liu, Xinshi Li, Wentao Li, Qiqi Zhang, Hua Bai, Junfang Li, Guangcheng Xi
Photothermal therapy (PTT) is one of promising cancer therapy with high efficiency and minimal invasiveness. Exploiting of perfect PTT agent is vital to improve the therapy. In this study, a new type of bow tie-like molybdenum dioxide (MoO2 ) nanoparticles was successfully synthesized. These nanobow-ties had strong localized surface plasmon resonance (SPR) effect from visible to near infrared regions, and exhibited ultrahigh chemical stability. They could not only withstand high temperature heating without oxidation, but also resist the corrosion of strong acid and alkali...
February 8, 2018: Biomaterials
https://www.readbyqxmd.com/read/29452288/repetitive-tlr-3-activation-in-the-lung-induces-skeletal-muscle-adaptations-and-cachexia
#11
Ted G Graber, Brandy L Rawls, Bing Tian, William J Durham, Camille R Brightwell, Allan R Brasier, Blake B Rasmussen, Christopher S Fry
Due to immunosenescence, older adults are particularly susceptible to lung-based viral infections, with increased severity of symptoms in those with underlying chronic lung disease. Repeated respiratory viral infections produce lung maladaptations, accelerating pulmonary dysfunction. Toll like 3 receptor (TLR3) is a membrane protein that senses exogenous double-stranded RNA to activate the innate immune response to a viral infection. Polyinosinic-polycytidylic acid [poly(I:C)] mimics double stranded RNA and has been shown to activate TLR3...
February 13, 2018: Experimental Gerontology
https://www.readbyqxmd.com/read/29451816/effects-of-teriparatide-on-morphology-of-aortic-calcification-in-aged-hyperlipidemic-mice
#12
Jeffrey J Hsu, Jinxiu Lu, Soban Umar, Jason T Lee, Rajan Kulkarni, Yichen Ding, Chih-Chiang Chang, Tzung K Hsiai, Akishige Hokugo, Ioannis Gkouveris, Sotirios Tetradis, Ichiro Nishimura, Linda L Demer, Yin Tintut
Calcific aortic vasculopathy correlates with bone loss in osteoporosis in an age-independent manner. Prior work suggests that teriparatide, the bone anabolic treatment for postmenopausal osteoporosis, may inhibit onset of aortic calcification. Whether teriparatide affects progression of pre-existing aortic calcification, widespread among this patient population, is unknown. Female apolipoprotein E-deficient mice were aged for over one year to induce aortic calcification, treated for 4.5 weeks with daily injections of control vehicle (PBS), teriparatide 40 µg/kg (PTH40) or 400 µg/kg (PTH400), and assayed for aortic calcification by micro-computed tomography (microCT) before and after treatment...
February 16, 2018: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/29451219/low-frequency-pulsed-electromagnetic-field-pretreated-bone-marrow-derived-mesenchymal-stem-cells-promote-the-regeneration-of-crush-injured-rat-mental-nerve
#13
NaRi Seo, Sung-Ho Lee, Kyung Won Ju, JaeMan Woo, BongJu Kim, SoungMin Kim, Jeong Won Jahng, Jong-Ho Lee
Bone marrow-derived mesenchymal stem cells (BMSCs) have been shown to promote the regeneration of injured peripheral nerves. Pulsed electromagnetic field (PEMF) reportedly promotes the proliferation and neuronal differentiation of BMSCs. Low-frequency PEMF can induce the neuronal differentiation of BMSCs in the absence of nerve growth factors. This study was designed to investigate the effects of low-frequency PEMF pretreatment on the proliferation and function of BMSCs and the effects of low-frequency PEMF pre-treated BMSCs on the regeneration of injured peripheral nerve using in vitro and in vivo experiments...
January 2018: Neural Regeneration Research
https://www.readbyqxmd.com/read/29450237/the-associations-among-personality-alcohol-related-protective-behavioural-strategies-pbs-alcohol-consumption-and-sexual-intercourse-in-irish-female-college-students
#14
Sinéad Moylett, Brian M Hughes
Introduction: The study presented one of the first examinations of the associations among personality, alcohol-related protective behavioural strategies (PBS), alcohol consumption, sexual intercourse and sex-related alcohol negative consequences in Irish, female college students ( n = 522). Methods: A cross-sectional observational design was employed and participants completed the study online. Participants completed measures of personality, alcohol-related PBS, alcohol consumption and sexual intercourse...
December 2017: Addictive Behaviors Reports
https://www.readbyqxmd.com/read/29449062/acoustic-and-perceptual-analyses-of-adductor-spasmodic-dysphonia-in-mandarin-speaking-chinese
#15
Zhipeng Chen, Jingyuan Li, Qingyi Ren, Pingjiang Ge
OBJECTIVE: The objective of this study was to examine the perceptual structure and acoustic characteristics of speech of patients with adductor spasmodic dysphonia (ADSD) in Mandarin. STUDY DESIGN: Case-Control Study MATERIALS AND METHODS: For the estimation of dysphonia level, perceptual and acoustic analysis were used for patients with ADSD (N = 20) and the control group (N = 20) that are Mandarin-Chinese speakers. For both subgroups, a sustained vowel and connected speech samples were obtained...
February 12, 2018: Journal of Voice: Official Journal of the Voice Foundation
https://www.readbyqxmd.com/read/29448884/ameliorating-the-in-vivo-antimalarial-efficacy-of-artemether-using-nanostructured-lipid-carriers
#16
Vanka Ravisankar, Gowthamarajan Kuppusamy, Praveen Kumar Simhadri, Uday Krishna Baruah, Veera Venkata Satyanarayana Reddy Karri, Vimal Pandey, Phanithi Prakash Babu
Cerebral malaria (CM) is a fatal neurological complication of Plasmodium falciparum infection that affects children (below five years old) in sub-Saharan Africa and adults in South-East Asia each year having the fatality rate of 10-25%. The survivors of CM also have high risk of long term neurological or cognitive deficits. The objective of the present investigation was to develop optimized nanostructured lipid carriers (NLCs) of artemether (ARM) for enhanced anti-malarial efficacy of ARM.NLCs of ARM were prepared by a combination of high speed homogenization (HSH) and probe sonication techniques...
February 16, 2018: Journal of Microencapsulation
https://www.readbyqxmd.com/read/29448664/preparation-of-partially-unzipped-carbon-nanotube-ag-pucnts-ag-nanocomposite-and-its-application-for-h%C3%A2-o%C3%A2-based-non-enzymatic-sensor
#17
Chang Su, Ningning Zhou, Pengju Guo, Lihuan Xu
In the present work, the nanocomposite of the silver nanoparticles decorated partially unzipped carbon nanotubes (PUCNTs) (PUCNTs/Ag) was fabricated by in situ method, and its application as a sensitive non-enzymatic hydrogen peroxide (H2O2) sensor was then explored correspondingly. The measurements of transmission electron microscopy (TEM), fourier transform infrared (FTIR) spectroscopy and ultraviolet visible (UV-vis) absorption spectrum proved that the PUCNTs/Ag composite has been successfully prepared and the Ag nanoparticles dispersed on the surface of the PUCNTs and entered the inner of unzipped MWCNTs...
March 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29447086/vitamin-d-down-regulates-the-expression-of-some-th17-cell-related-cytokines-key-inflammatory-chemokines-and-chemokine-receptors-in-experimental-autoimmune-encephalomyelitis
#18
Abdollah Jafarzadeh, Sayyed Vahab Azizi, Zahra Arabi, Rayhaneh Ahangar-Parvin, Marziyeh Mohammadi-Kordkhayli, Tiziana Larussa, Fariba Khatami, Maryam Nemati
OBJECTIVES: A spectrum of immunomodulatory properties was attributed to vitamin D (VD). Here, the VD effects on expression of some Th17 cell- related cytokines, chemokines and chemokine receptors were investigated in experimental autoimmune encephalomyelitis (EAE). METHODS: One group of C57BL/6 mice, considered as healthy group, was treated with phosphate buffered saline (PBS). EAE was induced in other three groups and treated from day +3 to +30 with PBS, olive oil (VD vehicle) or 200 ng of VD...
February 15, 2018: Nutritional Neuroscience
https://www.readbyqxmd.com/read/29446076/topical-application-of-glycyrrhetinic-acid-in-the-gingival-sulcus-inhibits-attachment-loss-in-lipopolysaccharide-induced-experimental-periodontitis-in-rats
#19
A Takamori, Y Yoshinaga, T Ukai, H Nakamura, Y Takamori, S Izumi, C Shiraishi, Y Hara
BACKGROUND AND OBJECTIVE: Attachment loss of the junctional epithelium and alveolar bone destruction are signs of periodontitis, which is mainly caused by an inflammatory response to dental plaque. Glycyrrhetinic acid (GA), a component of the licorice herb, has been shown to have important anti-inflammatory activities; however, there are no previous reports on the ability of its inhibitory effects to prevent periodontal diseases. Hence, in this study, using our experimental periodontitis model, we attempted to evaluate whether GA had an effect on the prevention of attachment loss and alveolar bone loss...
February 15, 2018: Journal of Periodontal Research
https://www.readbyqxmd.com/read/29444957/p38-activation-induces-the-dissociation-of-tristetraprolin-from-argonaute-2-to-increase-are-mrna-stabilization
#20
Mei-Yan Qi, Jing-Wen Song, Zhuo Zhang, Shuang Huang, Qing Jing
Tristetraprolin (TTP) destabilizes AU-rich element (ARE)-containing mRNA by directly binding with their 3'UTR. P38 stimulation substantially increases ARE-mRNA stability, at least through repressing TTP. However, the mechanism by which P38 keeps TTP inactive has not been fully understood. TTP and ARE-mRNA localize to processing bodies (PBs), the mRNA granules associated with mRNA silencing. Here, we detected the influence of P38 upon TTP localization within PBs and found that P38 regulates TTP localization within PBs...
February 14, 2018: Molecular Biology of the Cell
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