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https://www.readbyqxmd.com/read/29473531/diabetic-complications-and-insight-into-antidiabetic-potentialities-of-ethno-medicinal-plants-a-review
#1
Muhammad Bilal, Muhammad Sarfaraz Iqbal, Syed Bilal Shah, Tahir Rasheed, Hafiz M N Iqbal
BACKGROUND: The naturally inspired treatment options for several disease conditions and human-health related disorders such as diabetes mellitus have gained considerable research interest. In this context, naturally occurring plants and herbs with medicinal functionalities have gained special place than ever before in the current medicinal world. OBJECTIVE: The objective of this review is to extend the current knowledge in the clinical field related to the diabetic complications...
February 21, 2018: Recent Patents on Inflammation & Allergy Drug Discovery
https://www.readbyqxmd.com/read/29464380/the-metabolic-and-endocrine-characteristics-in-spinal-and-bulbar-muscular-atrophy
#2
Angela Rosenbohm, Susanne Hirsch, Alexander E Volk, Torsten Grehl, Julian Grosskreutz, Frank Hanisch, Andreas Herrmann, Katja Kollewe, Wolfram Kress, Thomas Meyer, Susanne Petri, Johannes Prudlo, Carsten Wessig, Hans-Peter Müller, Jens Dreyhaupt, Jochen Weishaupt, Christian Kubisch, Jan Kassubek, Patrick Weydt, Albert C Ludolph
OBJECTIVE: Spinal and bulbar muscular atrophy (SBMA) is caused by an abnormal expansion of the CAG repeat in the androgen receptor gene. This study aimed to systematically phenotype a German SBMA cohort (n = 80) based on laboratory markers for neuromuscular, metabolic, and endocrine status, and thus provide a basis for the selection of biomarkers for future therapeutic trials. METHODS: We assessed a panel of 28 laboratory parameters. The clinical course and blood biomarkers were correlated with disease duration and CAG repeat length...
February 20, 2018: Journal of Neurology
https://www.readbyqxmd.com/read/29462329/association-of-job-sectors-with-type-2-diabetes-mellitus-hypercholesterolemia-and-obesity-a-cross-sectional-study-from-the-malaysian-cohort-tmc-project
#3
Boekhtiar Borhanuddin, Norfazilah Ahmad, Shamsul Azhar Shah, Nor Azian Abdul Murad, Syed Zulkifli Syed Zakaria, Mohd Arman Kamaruddin, Nazihah Abd Jalal, Nurul Ain Mhd Yusuf, Afzan Effiza Abdul Patah, Andri Dauni, Wan Ahmad Faisal Wan Sallam, Rahman Jamal
Background: The investigation of risk factors of cardiovascular disease (e.g., major endocrine, nutritional and metabolic diseases) across job sectors is useful for targeted public health intervention. This study examined the occurrence of type 2 diabetes mellitus (T2DM), hypercholesterolemia and obesity in 21 job sectors in the general population. Methods: A baseline cross-sectional analysis of the Malaysian Cohort was conducted, which included 105 391 adults. Multiple logistic regression analyses were conducted for these three diseases across 20 job sectors compared with the unemployed/homemaker sector...
February 15, 2018: International Health
https://www.readbyqxmd.com/read/29461239/-secretory-function-of-white-adipose-tissue-and-adipokines-biological-effects-and-clinical-significance-review
#4
O Sulaieva, Y Chereshneva, N Kartashkina, M Ivanova, D Tsomartova
In addition to accumulation and metabolism of triglycerides, white adipose tissue is recognized as the active endocrine organ, whose dysfunction is associated with the development of a wide range of diseases. The secretome of adipocytes is represented by a wide range of adipokines, which vary in depot and sex-specific manner. In addition, adipokines have diverse biological effects, correlations with different metabolic features and functions. In this review, the data on biological effects, origin and the clinical significance of adipokines are discussed...
January 2018: Georgian Medical News
https://www.readbyqxmd.com/read/29459441/mechanisms-in-endocrinology-lessons-from-growth-hormone-receptor-gene-disrupted-mice-are-there-benefits-of-endocrine-defects
#5
Reetobrata Basu, Yanrong Qian, John J Kopchick
Growth hormone (GH) is produced primarily by anterior pituitary somatotroph cells. Numerous acute human (h) GH treatment and long-term follow-up studies and extensive use of animal models of GH action have shaped the body of GH research over the past 40-50 years. Work on the GH receptor (R) knock-out (GHRKO) mice and results of studies on GH resistant Laron Syndrome (LS) patients have helped define many physiological actions of GH including those dealing with metabolism, obesity, cancer, diabetes, cognition, and aging/longevity...
February 19, 2018: European Journal of Endocrinology
https://www.readbyqxmd.com/read/29458876/bone-densitometry-status-and-its-associated-factors-in-peri-and-post-menopausal-females-a-cross-sectional-study-from-a-tertiary-care-centre-in-india
#6
Jaya Chawla, Neena Sharma, Devendra Arora, Manisha Arora, Lovely Shukla
OBJECTIVE: Osteoporosis is a skeletal disorder characterized by diminished bone strength that increases the risk of fracture at instances of trivial trauma. Asians have a lower bone mass than the west. The present study was designed to add data from India on women above the age of 40 years with respect to low bone mineral density (BMD) and its associated high risk factors. MATERIALS AND METHODS: After a written informed consent, a detailed history was taken. Basal metabolic index was recorded, and biochemical and endocrine tests were done, followed by dual X ray absorptiometry scan...
February 2018: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29458219/clinical-endocrine-and-imaging-characteristics-of-patients-with-primary-hypophysitis
#7
Anna Angelousi, Carolina Cohen, Soledad Sosa, Karina Danilowicz, Lina Papanastasiou, Marina Tsoli, Aparna Pal, Georgios Piaditis, Ashley Grossman, Gregory Kaltsas
Primary hypophysitis (PH) is a rare disease with a poorly-defined natural history. Our aim was to characterise patients with PH at presentation and during prolonged follow-up. Observational retrospective study of 22 patients was conducted from 3 centres. In 14 patients, PH was confirmed histologically and in the remaining 8 clinically, after excluding secondary causes of hypophysitis. All patients had hormonal and imaging investigations before any treatment. Median follow up was 48 months (25-75%: 3-60). There was a female predominance with a female/male ratio: 3...
February 19, 2018: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/29452073/the-role-of-adiponectin-and-adipolin-as-anti-inflammatory-adipokines-in-the-formation-of-macrophage-foam-cells-and-their-association-with-cardiovascular-diseases
#8
REVIEW
Javad Sargolzaei, Elham Chamani, Tooba Kazemi, Soudabeh Fallah, Hosna Soori
Obesity is one of the major public health concerns that is closely associated with obesity-related disorders such as type 2 diabetes mellitus (T2DM), hypertension, and atherosclerosis. Atherosclerosis is a chronic disease characterized by excess cholesterol deposition in the arterial intima and the formation of foam cells. Adipocytokines or adipokines are secreted by the adipose tissue as endocrine glands; adiponectin and adipolin are among these adipokines that are associated with obese and insulin-resistant phenotypes...
February 13, 2018: Clinical Biochemistry
https://www.readbyqxmd.com/read/29451419/physical-exercise-nutrition-and-hormones-three-pillars-to-fight-sarcopenia
#9
Paolo Sgrò, Massimiliano Sansone, Andrea Sansone, Stefania Sabatini, Paolo Borrione, Francesco Romanelli, Luigi Di Luigi
BACKGROUND: Sarcopenia is a pathophysiological condition diffused in elderly people; it represents a social issue due to the longer life expectancy and the growing aging population. It affects negatively quality of life and it represents a risk factor for other pathologies, such as diabetes, cardiovascular disease, and obesity. No silver bullet exists to hinder sarcopenia, but it may be counteracted by physical exercise, nutrition, and a proper endocrine milieu. Indeed, we aim to analyze the scientific literature to give to clinician effective advices to counteract sarcopenia...
February 16, 2018: Aging Male: the Official Journal of the International Society for the Study of the Aging Male
https://www.readbyqxmd.com/read/29444795/agenesis-of-dorsal-pancreas-in-a-young-adult-a-rare-cause-of-diabetes-mellitus
#10
Satyendra Kumar Sonkar, Satish Kumar, Neeraj Kumar Singh
Dorsal pancreatic agenesis is an extremely rare entity characterised by absence of body and tail of pancreas, while there are so many other developmental anomalies of the pancreas that have been reported. Here we report a 25-year-old young man who presented with pain in the abdomen, recurrent loose stools and hyperglycaemia. On radiological imaging study, there was complete agenesis of the dorsal pancreas except for thin stripe of tissue at the level of the uncinate process. Both exocrinedysfunction and endocrine dysfunction were present in this patient...
February 14, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29442342/a-ten-year-follow-up-study-of-treatment-outcome-of-craniopharyngiomas
#11
Lukas Andereggen, Benjamin Hess, Robert Andres, Marwan El-Koussy, Luigi Mariani, Andreas Raabe, Rolf W Seiler, Emanuel Christ
PURPOSE: Craniopharyngioma-related hypothalamic obesity is a devastating complication with limited data on whether long-term follow-up should focus on problems other than endocrine deficiencies and weight gain. The primary endpoint was the assessment of predictors of hypothalamic obesity development; the secondary endpoint was the assessment of functional outcome (endocrine deficiencies, visual acuity) at long-term follow-up. METHODS: This retrospective case-note study examined craniopharyngioma patients with at least 2 years of follow-up...
February 14, 2018: Swiss Medical Weekly
https://www.readbyqxmd.com/read/29440941/sleep-disturbances-in-women-with-polycystic-ovary-syndrome-prevalence-pathophysiology-impact-and-management-strategies
#12
REVIEW
Renae C Fernandez, Vivienne M Moore, Emer M Van Ryswyk, Tamara J Varcoe, Raymond J Rodgers, Wendy A March, Lisa J Moran, Jodie C Avery, R Doug McEvoy, Michael J Davies
Polycystic ovary syndrome (PCOS) is a complex endocrine disorder affecting the reproductive, metabolic and psychological health of women. Clinic-based studies indicate that sleep disturbances and disorders including obstructive sleep apnea and excessive daytime sleepiness occur more frequently among women with PCOS compared to comparison groups without the syndrome. Evidence from the few available population-based studies is supportive. Women with PCOS tend to be overweight/obese, but this only partly accounts for their sleep problems as associations are generally upheld after adjustment for body mass index; sleep problems also occur in women with PCOS of normal weight...
2018: Nature and Science of Sleep
https://www.readbyqxmd.com/read/29438472/klinefelter-syndrome-integrating-genetics-neuropsychology-and-endocrinology
#13
Claus H Gravholt, Simon Chang, Mikkel Wallentin, Jens Fedder, Philip Moore, Anne Skakkebæk
Although first identified over 70 years ago, Klinefelter syndrome (KS) continue to pose significant diagnostic challenges, as many patients are still misdiagnosed, or remain undiagnosed. In fact, as few as 25% of KS patients are accurately diagnosed, and most of these diagnoses are not made until adulthood. Classic characteristics of KS include small testes, infertility, hypergonadothropic hypogonadism, and cognitive impairment. However, the pathophysiology behind KS is not well understood, although genetic effects are also thought to play a role...
February 9, 2018: Endocrine Reviews
https://www.readbyqxmd.com/read/29437698/islet-interleukin-1%C3%AE-immunoreactivity-is-an-early-feature-of-cystic-fibrosis-that-may-contribute-to-%C3%AE-cell-failure
#14
Rebecca L Hull, Ronald L Gibson, Sharon McNamara, Gail H Deutsch, Corinne L Fligner, Charles W Frevert, Bonnie W Ramsey, Srinath Sanda
OBJECTIVE: Cystic fibrosis-related diabetes (CFRD) is a common complication of cystic fibrosis (CF), increasing patient morbidity and mortality. Poor understanding of CFRD pathogenesis limits the development of targeted therapies to treat and/or prevent the disease. The aim of this study was to evaluate islet pathology, specifically, inflammation, amyloid deposition, and endocrine cell composition in subjects with CF with diabetes and with CF without diabetes. RESEARCH DESIGN AND METHODS: A retrospective analysis of archived pancreas tissue collected at autopsy was conducted using pancreas tissue from subjects with CF and diabetes (CFRD) ( n = 18) and CF without diabetes (CF-no DM) ( n = 17)...
February 1, 2018: Diabetes Care
https://www.readbyqxmd.com/read/29435181/hyperglycemia-induced-testicular-damage-in-type-2-diabetes-mellitus-rats-exhibiting-microcirculation-impairments-associated-with-vascular-endothelial-growth-factor-decreased-via-pi3k-akt-pathway
#15
Lingli Long, Han Qiu, Bing Cai, Ningning Chen, Xiaofang Lu, Shuhui Zheng, Xiaoxin Ye, Yubin Li
As an endocrine disease, type 2 diabetes mellitus (T2DM) can cause testicular damage which induces male infertility. However, the underlying mechanism is still not clear. We prove that T2DM induced testicular microcirculation impairment involves the decrease of VEGF and these actions are regulated by PI3K/Akt pathway. In our study, rats were divided into three groups (n=8): control group, diabetes group and diabetes + VEGF group. Intraperitoneal injection of streptozotocin (STZ, 65mg/Kg, at 9th week) and daily high-fat diet were used to establish T2DM rat model...
January 12, 2018: Oncotarget
https://www.readbyqxmd.com/read/29428804/links-between-a-biomarker-profile-cold-ischaemic-time-and-clinical-outcome-following-simultaneous-pancreas-and-kidney-transplantation
#16
Hussein A Khambalia, M Yvonne Alexander, Mahesan Nirmalan, Ria Weston, Phillip Pemberton, Zia Moinuddin, Angela Summers, David van Dellen, Titus Augustine
In sepsis, trauma and major surgery, where an explicit physiological insult leads to a significant systemic inflammatory response, the acute evolution of biomarkers have been delineated. In these settings, Interleukin (IL) -6 and TNF-α are often the first pro-inflammatory markers to rise, stimulating production of acute phase proteins followed by peaks in anti-inflammatory markers. Patients undergoing SPKT as a result of diabetic complications already have an inflammatory phenotype as a result of uraemia and glycaemia...
February 8, 2018: Cytokine
https://www.readbyqxmd.com/read/29422234/an-overview-of-type-2-diabetes-and-importance-of-vitamin-d3-vitamin-d-receptor-interaction-in-pancreatic-%C3%AE-cells
#17
REVIEW
Abraham Neelankal John, Fang-Xu Jiang
One significant health issue that plagues contemporary society is that of Type 2 diabetes (T2D). This disease is characterised by higher-than-average blood glucose levels as a result of a combination of insulin resistance and insufficient insulin secretions from the β-cells of pancreatic islets of Langerhans. Previous developmental research into the pancreas has identified how early precursor genes of pancreatic β-cells, such as Cpal, Ngn3, NeuroD, Ptf1a, and cMyc, play an essential role in the differentiation of these cells...
December 14, 2017: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/29421310/mortality-trends-and-cause-of-death-in-patients-with-new-onset-type-2-diabetes-and-controls-a-24-year-follow-up-prospective-cohort-study
#18
Tobias Andersson, Per Hjerpe, Axel C Carlsson, Aldina Pivodic, Per Wändell, Karin Manhem, Kristina Bengtsson Boström
AIMS: Our aim was to assess causes of death and temporal changes in excess mortality among patients with new-onset type 2 diabetes in Skaraborg, Sweden. METHODS: Patients from the Skaraborg Diabetes Register with prospectively registered new-onset type 2 diabetes 1991-2004 were included. Five individual controls matched for sex, age, geographical area and calendar year of study entry were selected using population records. Causes of deaths until 31 December 2014 were retrieved from the Cause of Death Register...
February 5, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29420708/sex-differences-in-maturation-of-human-embryonic-stem-cell-derived-beta-cells-in-mice
#19
Nelly Saber, Jennifer E Bruin, Shannon O'Dwyer, Hellen Schuster, Alireza Rezania, Timothy J Kieffer
Pancreatic progenitors derived from human embryonic stem cells (hESCs) are now in clinical trials for insulin replacement in patients with type 1 diabetes. Animal studies indicate the cells can mature into a mixed population of pancreatic endocrine cells including glucose-responsive beta cells several months after implant, but it remains unclear how conditions in the recipient may influence the maturation and ultimately the function of these cells. Here, we investigated the effects of the host sex and pregnancy on the maturation of human Stage 4 (S4) pancreatic progenitor cells and more mature Stage 7 (S7) pancreatic endocrine cells implanted under the kidney capsule of immunodeficient SCID-Beige mice...
February 5, 2018: Endocrinology
https://www.readbyqxmd.com/read/29415563/body-mass-index-effect-on-differing-responses-to-psychological-stress-in-blood-glucose-dynamics-in-patients-with-type-1-diabetes
#20
Basak Ozaslan, Stephen D Patek, Jesse H Grabman, Jaclyn A Shepard, Eyal Dassau, Marc D Breton, Yogish C Kudva, Sue A Brown, Ananda Basu, Jordan E Pinsker, Francis J Doyle, Linda Gonder-Frederick
OBJECTIVE: The objective was to investigate the relationship of body mass index (BMI) to differing glycemic responses to psychological stress in patients with type 1 diabetes. METHODS: Continuous blood glucose monitor (CGM) data were collected for 1 week from a total of 37 patients with BMI ranging from 21.5-39.4 kg/m2 (mean = 28.2 ± 4.9). Patients reported daily stress levels (5-point Likert-type scale, 0 = none, 4 = extreme), physical activity, carbohydrate intake, insulin boluses and basal rates...
February 1, 2018: Journal of Diabetes Science and Technology
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