keyword
MENU ▼
Read by QxMD icon Read
search

Beh

keyword
https://www.readbyqxmd.com/read/28430855/cancer-immunotherapy-trial-registrations-increase-exponentially-but-chronic-immunosuppressive-glucocorticoid-therapy-may-compromise-outcomes
#1
C M Connell, S Raby, I Beh, T Flint, E Williams, D T Fearon, D I Jodrell, T Janowitz
No abstract text is available yet for this article.
April 14, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/28423776/application-of-correspondence-analysis-to-graphically-investigate-associations-between-foods-and-eating-locations
#2
Andrew N Chapman, Eric J Beh, Luigi Palla
This paper presents the application of correspondence analysis (CA) for investigating associations using confidence regions (CRs) with a focus on facilitating mining the data and hypothesis generation. We study the relationship between locations and "less-healthy" food consumption by UK teenagers. CA allows for a quick visual inspection of the various association structures that exist between the categories of cross-classified variables in large datasets derived with varying study designs. The hypotheses generated by the visual display can then be independently tested using suitable regression models...
2017: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/28414972/an-lc-ms-ms-method-for-quantification-of-ac0010-a-novel-mutant-selective-epidermal-growth-factor-receptor-egfr-inhibitor-and-its-metabolites-in-human-plasma-and-the-application-to-a-pharmacokinetic-study
#3
Lu Wang, Xin Zheng, Weicong Wang, Pei Hu, Ji Jiang
AC0010 is an irreversible, mutant-selective EGFR inhibitor that effectively inhibits EGFR active and T790M resistance mutations in non-small cell lung cancer (NSCLC). A sensitive ultra-performance liquid chromatography - tandem mass spectrometry (UPLC-MS/MS) method was developed and fully validated for determining AC0010 and its metabolites in human plasma. The samples were purified by solid-phase extraction (SPE) columns and separated on a BEH C18 column. Electrospray ionization (ESI) in positive ion mode and multiple reaction monitoring (MRM) were used to monitor the ion transitions of AC0010 (m/z 488→257) and its metabolites M1 (m/z 474→403), M2 (m/z 504→487), M4 (m/z 434→377), M7 (m/z 490→405), MII-1 (m/z 651→434) and MII-2 (m/z 609→434)...
March 28, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28403574/determination-of-artemisitene-in-rat-plasma-by-uplc-ms-ms-and-its-application-in-pharmacokinetics
#4
Lilan Wu, Yunshan Wu, Weiying Chen, Wen Zhou, Lipeng Tang, Ben Li, Bo Liu
RATIONALE: Artemisitene showed a wide variety of pharmacological activities, such as antioxidant protection in vitro and in vivo. It has been identified as a novel Nrf2 inducer. However, there is no report on an UPLC-MS/MS method to quantitate artemisitene in rat plasma and its application on pharmacokinetic profile study. METHODS: An ACQUITY UPLC(TM) BEH Symmetry ShieldRP18 column (1.7 µm, 2.1 mm × 100 mm) was used with a flow rate of 0.3 mL · min(-1) ...
April 12, 2017: Rapid Communications in Mass Spectrometry: RCM
https://www.readbyqxmd.com/read/28403317/attention-memory-visuoconstructive-and-executive-task-performance-in-adolescents-with-anxiety-disorders-a-case-control-community-study
#5
Rafaela Behs Jarros, Giovanni Abrahão Salum, Cristiano Tschiedel Belem da Silva, Rudineia Toazza, Natália Becker, Marilyn Agranonik, Jerusa Fumagalli de Salles, Gisele Gus Manfro
Objective: The aim of the present study was to assess children and adolescents with mild and severe anxiety disorders for their performance in attention, verbal episodic memory, working memory, visuoconstructive skills, executive functions, and cognitive global functioning and conduct comparative analyses with the performance of children free from anxiety disorders. Methods: Our sample comprised 68 children and adolescents aged 10 to 17 years (41 with current diagnoses of anxiety disorders and 27 controls) selected from a larger cross-sectional community sample of adolescents...
January 2017: Trends in Psychiatry and Psychotherapy
https://www.readbyqxmd.com/read/28398911/increased-epicardial-fat-thickness-in-sudden-death-from-stable-coronary-artery-atherosclerosis
#6
Belinda Fuller, Jack Garland, Sravan Anne, Raymond Beh, Dennis McNevin, Rexson Tse
BACKGROUND: Sudden death from stable coronary artery atherosclerosis (SCAA) is well recognized. However, individuals can have ischemic heart disease or coronary artery atherosclerosis but die of noncardiac causes. Recently, it has been recognized that increased epicardial fat is detrimental to normal heart function. We hypothesize that individuals who die of SCAA have increased epicardial fat. AIM: The aim of this study was to investigate whether there is an increase in epicardial fat in individuals who suddenly died of SCAA...
April 11, 2017: American Journal of Forensic Medicine and Pathology
https://www.readbyqxmd.com/read/28392327/new-liquid-chromatography-tandem-mass-spectrometry-method-for-routine-tdm-of-vancomycin-in-patients-with-both-normal-and-impaired-renal-functions-and-comparison-with-results-of-polarization-fluoroimmunoassay-in-light-of-varying-creatinine-concentrations
#7
Hana Brozmanová, Ivana Kacířová, Romana Uřinovská, Pavel Šištík, Milan Grundmann
A new LC-MS/MS method with simple sample extraction and a relatively short period of vancomycin analysis for routine therapeutic drug monitoring was developed and validated. 50μL serum was precipitated using 20μL 33% trichloroacetic acid and 0.5mol/L NH4OH was added to increase pH before analysis. A RP BEH C18, 1.7μm, 2.1×50mm column maintained at 30°C and tobramycin as internal standard were used. Mass detection was performed in positive electrospray mode. The results obtained with LC-MS/MS method were correlated with an FPIA assay (Abbott AxSYM) using mouse monoclonal antibody...
April 7, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/28370149/determination-of-4-1-3-dioxo-1-3-dihydro-2h-isoindol-2-yl-n-4-ethoxyphenyl-methylidene-benzohydrazide-a-novel-anti-inflammatory-agent-in-biological-fluids-by-uplc-ms-ms-assay-development-validation-and-in-vitro-metabolic-stability-study
#8
Muzaffar Iqbal, Mashooq A Bhat, Mohammad Raish, Essam Ezzeldin
A thalidomide analogue, (4-(1,3-dioxo-1,3-dihydro-2H-isoindol- 2-yl)-N'-[(4-ethoxyphenyl) methylidene] benzohydrazide), has been identified as a promising broad spectrum anti-inflammatory agent in previous study. In this study, a sensitive and selective UPLC-MS/MS assay was developed and validated for its determination in rat plasma samples. The chromatographic separation was performed on Aquity BEH C18 column using mobile phase comprising of acetonitrile and 10 mM ammonium acetate in the ratio of 85:15, at flow rate of 0...
March 31, 2017: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/28365413/ultra-performance-liquid-chromatography-tandem-mass-spectrometry-for-determination-of-direct-acting-antiviral-drugs-in-human-liver-fine-needle-aspirates
#9
Andrew J Ocque, Colleen E Hagler, Robin DiFrancesco, Gene D Morse, Andrew H Talal
An ultra-performance liquid chromatography with triple quadrupole mass spectrometry method was developed and validated for the determination of direct acting antiviral drug concentrations in human liver fine needle aspirates. Liver fine needle aspirate (FNA) biopsy samples were homogenized in acetonitrile to stabilize the analytes and precipitate protein. The acetonitrile supernatants were diluted with internal standards and mobile phase. Separation was achieved with a Waters Acquity BEH C18 column (50×2.1mm, 1...
March 24, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28363092/vehicles-as-outdoor-bfr-sources-evidence-from-an-investigation-of-bfr-occurrence-in-road-dust
#10
Zhiguo Cao, Leicheng Zhao, Jiangmeng Kuang, Qiaoying Chen, Guifen Zhu, Kunlun Zhang, Shihua Wang, Peipei Wu, Xin Zhang, Xuefeng Wang, Stuart Harrad, Jianhui Sun
The distribution of brominated flame retardants (BFRs) including ∑8PBDEs, DBDPE, BTBPE, EH-TBB, BEH-TEBP and PBEB in road dust (RD) collected in Xinxiang, China was characterized. Analysis of RD samples indicated that the BFR abundance declined as traffic density decreased, with total mean levels of 292, 184, 163, 104 and 70 ng g(-1) dust at sites from traffic intersections, main roads, collector streets, bypasses and parks, respectively. A possible explanation for this phenomenon is that the majority of BFRs may be emitted from the interior of vehicles via their ventilation systems...
July 2017: Chemosphere
https://www.readbyqxmd.com/read/28352153/development-of-erythropoietin-receptor-targeted-drug-delivery-system-against-breast-cancer-using-tamoxifen-loaded-nanostructured-lipid-carriers
#11
Chaw Yee Beh, Chee Wun How, Jhi Biau Foo, Jia Ning Foong, Gayathri Thevi Selvarajah, Abdullah Rasedee
Tamoxifen (TAM) has been used in the treatment of breast cancers and is supplemented with erythropoietin (EPO) to alleviate the cancer-related anemia. The purported deleterious effects caused by the use of EPO with chemotherapeutic agents in the treatment of cancer-related anemia vary across studies and remain controversial. The use of nanoparticles as a drug delivery system has the potential to improve the specificity of anticancer drugs. In this study, we simultaneously incorporated two pharmacological active ingredients in one nanocarrier to develop EPO-conjugated TAM-loaded lipid nanoparticles (EPO-TAMNLC), a targeted delivery system, to enhance the cytotoxic activity while reducing the side effects of the ingredients...
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/28337929/a-public-health-approach-in-responding-to-the-spread-of-helium-suicide-in-hong-kong
#12
Paul S F Yip, Qijin Cheng, Shu-Sen Chang, Esther Sze Tsai Lee, Chui-Shan Carmen Lai, Feng Chen, Yik-Wa Frances Law, T M Eric Cheng, Sau Mee Chiu, Y L Jeff Tse, Ka-Wai Raymond Cheung, Man-Li Tse, Peter R Morgan, Philip Beh
BACKGROUND: The use of the helium suicide method has been increasing in popularity in Hong Kong since 2012. We have learned a valuable lesson in curbing the spread of charcoal burning (CB) suicide in the past 15 years and hope to prevent the helium suicide method from taking off in the community. AIMS: To document what actions have been taken to contain the spread of the helium suicide method and review the preliminary impact of these actions. METHOD: We adopted a public health approach by engaging stakeholders from multiple sectors, including the police force, the fire services department, coroners, pathologists, mass media, and online media outlets...
March 24, 2017: Crisis
https://www.readbyqxmd.com/read/28335995/assessment-of-dietary-exposure-to-organohalogen-contaminants-legacy-and-emerging-flame-retardants-in-a-norwegian-cohort
#13
Fuchao Xu, Joo-Hui Tay, Adrian Covaci, Juan Antonio Padilla-Sánchez, Eleni Papadopoulou, Line Småstuen Haug, Hugo Neels, Ulla Sellström, Cynthia A de Wit
Polychlorinated biphenyls (PCBs), organochlorine pesticides (OCPs), polybrominated diphenyl ethers (PBDEs), emerging halogenated flame retardants (EHFRs) and organophosphate flame retardants (PFRs) were detected in 24h duplicate diet samples from a Norwegian cohort (n=61), with concentrations ranging from <method limit of quantification (MLQ)-0.64ng/g ww, <MLQ-0.70ng/g ww, <MLQ-0.93ng/g ww, <MLQ-0.14ng/g ww, and <MLQ-150ng/g ww, respectively. All studied contaminants were detected in the duplicate diet samples with detection frequencies (DF) ranging from 1...
March 20, 2017: Environment International
https://www.readbyqxmd.com/read/28330482/development-of-a-model-of-saint-louis-encephalitis-infection-and-disease-in-mice
#14
Rafael Elias Marques, Juliana L Del Sarto, Rebeca P F Rocha, Giovanni F Gomes, Allysson Cramer, Milene A Rachid, Danielle G Souza, Maurício L Nogueira, Mauro M Teixeira
BACKGROUND: Flaviviruses are a genre of closely related viral pathogens which emerged in the last decades in Brazil and in the world. Saint (St.) Louis encephalitis virus (SLEV) is a neglected flavivirus that can cause a severe neurological disease that may lead to death or sequelae. St. Louis encephalitis pathogenesis is poorly understood, which hinders the development of specific treatment or vaccine. METHODS: To address this problem, we developed a model of SLEV infection in mice to study mechanisms involved in the pathogenesis of severe disease...
March 22, 2017: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/28328039/reduction-of-metal-adducts-in-oligonucleotide-mass-spectra-in-ion-pair-reversed-phase-chromatography-mass-spectrometry-analysis
#15
Robert E Birdsall, Martin Gilar, Henry Shion, Ying Qing Yu, Weibin Chen
RATIONALE: Electrospray ionization mass spectrometry (ESI-MS)-based techniques commonly used in oligonucleotide analyses are known to be sensitive to alkali metal adduct formation. Adducts directly impact the sensitivity of MS-based analyses as the available charge is distributed across the parent peak and adduct(s). The current study systematically evaluated common liquid chromatography (LC) components in LC/ESI-MS configurations used in oligonucleotide analysis to identify metal adduct contributions from LC instrumentation...
July 30, 2016: Rapid Communications in Mass Spectrometry: RCM
https://www.readbyqxmd.com/read/28319741/influence-of-sampling-approach-on-concentrations-of-legacy-and-novel-brominated-flame-retardants-in-indoor-dust
#16
Layla Salih Al-Omran, Stuart Harrad
The study investigates the impact of sampling method on the concentrations of PBDEs (BDE-28, BDE-47, BDE-99, BDE-100, BDE-153, BDE-154, BDE-183, and BDE-209) and NBFRs (PBEB, EH-TBB, BEH-TEBP, BTBPE and DBDPE) in indoor dust. A total of 36 dust samples were collected from 12 homes in Birmingham, UK (3 samples per home comprising researcher collected dust - both RCD from the living room (RCDL) and bedroom (RCDB), with an additional householder vacuum dust sample - HHVD). BDE-209 was the predominant compound, with average concentrations of 2642, 2336 and 2634 ng/g in RCDL, RCDB and HHVD respectively...
February 22, 2017: Chemosphere
https://www.readbyqxmd.com/read/28314201/inhibition-of-mirna-212-132-improves-the-reprogramming-of-fibroblasts-into-induced-pluripotent-stem-cells-by-de-repressing-important-epigenetic-remodelling-factors
#17
Nils Pfaff, Steffi Liebhaber, Selina Möbus, Abbas Beh-Pajooh, Jan Fiedler, Angelika Pfanne, Axel Schambach, Thomas Thum, Tobias Cantz, Thomas Moritz
MicroRNAs (miRNAs) repeatedly have been demonstrated to play important roles in the generation of induced pluripotent stem cells (iPSCs). To further elucidate the molecular mechanisms underlying transcription factor-mediated reprogramming we have established a model, which allows for the efficient screening of whole libraries of miRNAs modulating the generation of iPSCs from murine embryonic fibroblasts. Applying this model, we identified 14 miRNAs effectively inhibiting iPSC generation, including miR-132 and miR-212...
April 2017: Stem Cell Research
https://www.readbyqxmd.com/read/28306207/development-and-validation-of-a-uhplc-ms-ms-method-for-the-simultaneous-determination-of-five-bioactive-flavonoids-in-rat-plasma-and-comparative-pharmacokinetic-study-after-oral-administration-of-xiaochaihu-tang-and-three-compatibilities
#18
Yunhai Bo, Lijuan Wang, Xiao Wu, Longshan Zhao, Jingyu Yang, Zhili Xiong, Chunfu Wu
An accurate, rapid and reliable ultra high performance liquid chromatography with tandem mass spectrometry method was developed and validated for the simultaneous determination of baicalin, wogonoside, baicalein, wogonin and oroxylinA in rat plasma. Then, the stability of baicalin and baicalein in the preparation of plasma sample was systematically investigated. The Waters BEH C18 column was used with a gradient mobile phase system of acetonitrile and water containing 0.1% formic acid. The analytes were detected in the multiple reaction monitoring mode with positive electrospray ionization...
March 17, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/28304241/wireless-teleophthalmology-a-novel-low-cost-flexible-network-architecture-and-its-performance-evaluation-for-remote-eye-care-solutions
#19
Shashwat Pathak, Basant Kumar
INTRODUCTION: This article proposes a novel, cost-effective, flexible, and easy-to-deploy wireless teleophthalmology network architecture and performance evaluation for its potential use in remote areas. This study has used practical telecommunication standards, which is widely deployed throughout India. METHODS: In the proposed scenario, patient's eye images are obtained using a specified imaging modality, and then sent to a server at the primary eye care centre (PECC) using ZigBee a short-range wireless network...
March 17, 2017: Telemedicine Journal and E-health: the Official Journal of the American Telemedicine Association
https://www.readbyqxmd.com/read/28303226/simultaneous-determination-of-14-active-constituents-of-shengjiang-xiexin-decoction-using-ultrafast-liquid-chromatography-coupled-with-electrospray-ionization-tandem-mass-spectrometry
#20
Gang Peng, Huanyu Guan, Xiaoming Wang, Yue Shi
An effective herbal medicinal prescription of Shengjiang Xiexin decoction (SXD) was used in treating the inflammatory bowel disease in clinic. In this study, an ultrafast liquid chromatography-tandem mass spectrometry (UFLC-MS/MS) method was developed to separate and to simultaneously determine 14 major active ingredients in SXD. Chromatographic separation was successfully accomplished on an Acquity BEH C18 (100 mm×2.1 mm, 1.7 μm) column using gradient elution with 0.1% (v/v) formic acid water (A) and 0...
March 2017: Acta Pharmaceutica Sinica. B
keyword
keyword
119634
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"