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https://www.readbyqxmd.com/read/29149568/individual-atomic-imaging-of-multiple-dopant-sites-in-as-doped-si-using-spectro-photoelectron-holography
#1
Kazuo Tsutsui, Tomohiro Matsushita, Kotaro Natori, Takayuki Muro, Yoshitada Morikawa, Takuya Hoshii, Kuniyuki Kakushima, Hitoshi Wakabayashi, Kouichi Hayashi, Fumihiko Matsui, Toyohiko Kinoshita
The atomic scale characterization of dopant atoms in semiconductor devices to establish correlations with the electrical activation of these atoms is the essential to the advancement of contemporary semiconductor process technology. Spectro-photoelectron holography combined with first-principles simulations can determine the local three-dimensional atomic structures of dopant elements, which in turn affect their electronic states. In the work reported herein, this technique was used to examine arsenic (As) atoms doped into a silicon (Si) crystal...
November 17, 2017: Nano Letters
https://www.readbyqxmd.com/read/29148582/comparative-pharmacokinetics-study-of-orientin-in-rat-plasma-by-uhplc-ms-ms-after-intravenous-administration-of-single-orientin-and-trollius-chinensis-bunge-extract
#2
Nan Zhao, Qi Sun, Yang Song, Lin Wang, Tingjian Zhang, Fanhao Meng
Orientin showed a broad array of biological activities, and it is the major bioactive compound in the Trollius chinensis Bunge. Thus, this paper was conducted to investigate the comparative pharmacokinetics of orientin after intravenous administration of single orientin and Trollius chinensis Bunge extract. Sample preparation involved a simple one-step deproteinization procedure with acetonitrile. Chromatographic separation was achieved on a Waters BEH C18 column with a mobile phase consisting of acetonitrile and water containing 0...
November 17, 2017: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/29136849/simultaneous-determination-of-three-estrogens-in-human-saliva-without-derivatization-or-liquid-liquid-extraction-for-routine-testing-via-miniaturized-solid-phase-extraction-with-lc-ms-ms-detection
#3
Xiaoguang Sunny Li, Shu Li, Gottfried Kellermann
Accurate quantitation of estrogens (i.e, estrone (E1), estradiol (E2) and estriol (E3)) is valuable for clinical assessment of human health and disease. Alterations in estrogen levels have been implicated in numerous pathological conditions. However, inadequacies in sensitivity and specificity, cumbersome sample preparation and invasive specimen collection hamper the usability of available methods for clinical applications. Herein, a simple, rapid, highly sensitive and specific LC-MS/MS method was developed and validated for the simultaneous determination of three estrogens in human saliva providing a non-invasive alternative to conventional blood samples...
February 1, 2018: Talanta
https://www.readbyqxmd.com/read/29132024/a-hilic-uhplc-ms-ms-untargeted-urinary-metabonomics-combined-with-quantitative-analysis-of-five-polar-biomarkers-on-osteoporosis-rats-after-oral-administration-of-gushudan
#4
Xiao Wu, Yue Huang, Jinghan Sun, Yongqing Wen, Feng Qin, Longshan Zhao, Zhili Xiong
A HILIC-UHPLC-MS/MS untargeted urinary metabonomic method combined with quantitative analysis of five potential polar biomarkers in rat urine was developed and validated, to further understand the anti-osteoporosis effect of Gushudan(GSD) and its mechanism on prednisolone-induced osteoporosis(OP) rats in this study. The metabolites were separated and identified on Waters BEH HILIC (2.1mm×100mm, 1.7μm) column using the Waters ACQUITY™ ultra performance liquid chromatography system (Waters Corporation, Milford, USA) coupled with a Micromass Quattro Micro™ API mass spectrometer (Waters Corp, Milford, MA, USA)...
October 6, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29132022/determination-of-perfluoroalkyl-acid-isomers-in-biosolids-biosolids-amended-soils-and-plants-using-ultra-high-performance-liquid-chromatography-tandem-mass-spectrometry
#5
Hongna Zhang, Bei Wen, Wen Wen, Yibing Ma, Xiaoyu Hu, Yali Wu, Lei Luo, Shuzhen Zhang
Isomer-specific analysis of perfluoroalkyl acids (PFAAs) is important to accurately assess their environmental source, fate, and human risks. In this study, a method was developed for the determination of perfluorooctanoic acid (PFOA), perfluorooctane sulfonate (PFOS), and perfluorohexane sulfonate (PFHxS) isomers in biosolids, biosolids-amended soils and plants using ultra-high performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS). The separation efficiencies of two chromatographic columns and extraction capacities of different methods were tested...
November 6, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29129432/occurrence-and-human-exposure-to-brominated-and-organophosphorus-flame-retardants-via-indoor-dust-in-a-brazilian-city
#6
Joyce Cristale, Tiago Gomes Aragão Belé, Silvia Lacorte, Mary Rosa Rodrigues de Marchi
Indoor dust is considered an important human exposure route to flame retardants (FRs), which has arised concern due the toxic properties of some of these substances. In this study, ten organophosphorus flame retardants (OPFRs), eight polybrominated diphenyl ethers (PBDEs) and four new brominated flame retardants (NBFRs) were determined in indoor dust from different places in Araraquara-SP (Brazil). The sampled places included houses, apartments, offices, primary schools and cars. The analysis of the sample extracts was performed by gas chromatography coupled to mass spectrometry and two ionization techniques were used (electron ionization - EI; electron capture negative ionization - ECNI)...
November 9, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/29125422/characteristics-of-morphologic-macular-abnormalities-in-neuroimmunology-practice
#7
Omar Al-Louzi, Elias S Sotirchos, Angela Vidal-Jordana, Shin C Beh, Julia Button, Howard S Ying, Laura J Balcer, Elliot M Frohman, Shiv Saidha, Peter A Calabresi, Scott D Newsome
BACKGROUND: Morphologic macular abnormalities (MMAs) are frequently seen on macular optical coherence tomography (OCT) imaging in neuroimmunology practice, yet studies pragmatically assessing prevalence and risk factors of MMAs to date are limited. OBJECTIVE: To describe the characteristics of MMAs in a neuroimmunology-based academic practice. METHODS: Cross-sectional study of 1450 patients (2900 eyes) who underwent spectral-domain macular OCT between June 2010 and June 2012...
November 1, 2017: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/29121571/high-throughput-%C3%AE-spe-based-elution-coupled-with-uplc-ms-ms-for-determination-of-eluxadoline-in-plasma-sample-application-in-pharmacokinetic-characterization-of-plga-nanoparticle-formulations-in-rats
#8
Muzaffar Iqbal, Essam Ezzeldin, Khalid A Al-Rashood, Ramadan Al-Shdefat, Md Khalid Anwer
Eluxadoline is a novel μ- and κ-opioid receptor (OR) agonist and δ-OR antagonist, recently approved as a first line therapy for the treatment of irritable bowel syndrome. Due to abuse potential, poor bioavailability and high intersubject variability, a sensitive and reliable assay is prerequisite for its determination in biological samples. This work first time report the development and validation of UPLC-MS/MS assay for determination of eluxadoline in rat plasma sample using risperidone as an internal standard (IS)...
October 28, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29120359/simultaneous-determination-of-seven-components-in-rat-plasma-by-the-uplc-ms-ms-method-and-application-of-pharmacokinetic-studies-to-simiaoyong-an-decoction
#9
Yuanyan Liu, Sensen Chi, Weihua Wang, Lei Su, Bin Liu
SimiaoYong'an Decoction (SYD) is a classical traditional Chinese prescription that is used for the treatment of gangrene, heat-clearing, detoxification and pain alleviation. We developed a sensitive ultra-performance liquid chromatography-tandem mass spectrum (UPLC-MS/MS) method for the simultaneous determination of seven major active ingredients of SYD extract (i.e., harpagide, chlorogenic acid, sweroside, loganin, liquiritin, angoroside C and harpagoside) in rat plasma. The preliminary steps in the plasma analysis were the addition of an internal standard such as linarin, followed by protein precipitation with methanol...
November 9, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29111491/uhplc-method-for-multiproduct-pharmaceutical-analysis-by-quality-by-design
#10
Ludivine Ferey, Adrien Raimbault, Isabelle Rivals, Karen Gaudin
An innovative Analytical Quality-by-Design (AQbD) methodology was followed to develop a specific and robust UHPLC method for the simultaneous separation of 16 active pharmaceutical ingredients (APIs). In the context of pharmaceutical repositioning, these molecules have been selected as good candidates for buccal per mucous (BPM(®)) administration route. Given the structural and physico-chemical diversity of compounds, an innovative development strategy based on QbD was applied. The main advantage of QbD is to ensure the robustness of the method...
October 16, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29110318/simultaneous-determination-and-pharmacokinetic-study-of-giraldoid-a-giraldoid-b-in-rat-plasma-after-oral-administration-of-daphne-giraldii-nitsche-extracts-by-lc-ms-ms
#11
Huyiligeqi, Xiaoxv Dong, Jing Fu, Sali Cao, Chunjing Yang, Longtai You, Zhongyi Zhang, Jian Ni
A simple sensitive LC-MS/MS method has been developed for the simultaneous determination of giraldoid A and giraldoid B in rat plasma. The method was applied to the pharmacokinetics studies of the two compounds from Daphne giraldii Nitsche. Chromatographic separation was accomplished on an ACQUITY UPLC™ BEH C18 column (100 × 2.1 mm, 1.7 mm) by gradient elution with a flow rate of 0.2 mL min(-1). The method was linear over the concentration range of 1.0-1000 ng mL(-1) , and the lower limit of quantification were 1...
November 7, 2017: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/29107729/quantitative-determination-of-chromium-picolinate-in-animal-feeds-by-solid-phase-extraction-and-liquid-chromatography-tandem-mass-spectrometry
#12
Miaomiao Han, Ying Tian, Zhen Li, Yiqiang Chen, Wenjun Yang, Liying Zhang
Chromium picolinate is one of the important Cr(3+) resources and is widely used in animal production. A convenient, reliable and rapid liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed and validated for the quantitative determination of chromium picolinate in animal feeds. Feed samples were extracted with acetonitrile and subsequently cleaned up by solid phase extraction cartridges Supelclean™ LC-18. Chromium picolinate was efficiently separated with a Waters ACQUITY UPLC(®) BEH C18 column, ionized with electrospray ion source in positive mode (ESI(+)), and quantitatively determined by tandem mass spectrometry in multiple reaction monitoring mode...
October 16, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29082693/-quantitative-analysis-of-eight-polyacetylenes-derived-from-bupleuri-radix-by-ultra-performance-liquid-chromatography-coupled-with-photodiode-array-detector
#13
Feng Zhang, Yuan Fang, Yu-Zhi Zhou, Jun-Sheng Tian, Xue-Mei Qin, Xiao-Xia Gao
To establish quantitative methods for determination of polyacetylenes in Bupleuri Radix, an ultra-performance liquid chromatography method coupled with photodiode array detector (UPLC-PDA) was developed. The analysis was performed on a Waters BEH C₁₈ column (2.1 mm×100 mm, 1.7 μm) using a gradient system of methanol and water. The flow rate was 0.3 mL•min⁻¹ and the detection wavelength was 315 nm. Eight polyacetylenes were prepared using traditional extraction and isolation method, of which compounds 7 and 8 were two new polyacetylenes...
May 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29082690/-uplc-q-tof-ms-for-rapid-analysis-of-chemical-constituents-in-sanhuang-tablets
#14
Meng-Jiao Liu, Yun Wang, Ling-Yun Li, Xiao-Qing Li, Ye-Jia Dai, Xue Zhang, Yin-Lian Ma, Cun Zhang, Wen-Lan Li
The qualitative analysis method of ultra performance liquid chromatography tandem quadrupole time of flight mass spectrometry (UPLC-Q-TOF-MS/MS) was established for the chemical constituents in Sanhuang tablets. Waters ACQUITY BEH C₁₈ (2.1 mm×100 mm, 1.7 μm) column was used with 0.1% formic acid solution (A)-0.1% formic acid acetonitrile (B) as the mobile phase for gradient elution. The flow rate was 0.2 mL•min⁻¹; the sample volume was 1 μL and the column temperature was 30 ℃. The high-resolution quadrupole time-flight mass spectrometry was used as detector with electrospray ion source in both positive and negative models, and the dry gas temperature was 325 ℃...
May 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29074519/development-and-pilot-testing-of-a-decision-aid-for-the-initiation-of-antipsychotic-medications-in-persons-with-dementia-in-long-term-care-using-a-systematic-approach-a-study-protocol
#15
Leslie J Malloy-Weir, Andrew Kirk
INTRODUCTION: Antipsychotic medications are commonly used in long-term care to treat neuropsychiatric symptoms of dementia despite concerns that their risks (eg, infection, falls, death) may outweigh their benefits. This study protocol outlines the development and pilot testing of a decision aid for antipsychotic medications that is tailored to the information needs of residents with dementia in long-term care and family caregivers (or decision makers). The goals of the decision aid are to help residents and caregivers (1) better understand the risks and benefits of antipsychotic medications in long-term care, and (2) make informed decisions about their use (or non-use)...
October 25, 2017: BMJ Open
https://www.readbyqxmd.com/read/29059614/a-liquid-chromatography-and-tandem-mass-spectrometry-method-to-determine-28-non-volatile-drugs-of-abuse-in-exhaled-breath
#16
Shahid Ullah, Sören Sandqvist, Olof Beck
Exhaled breath carries aerosol micro-particles containing nonvolatile organic substances. Recently, the analysis of drugs of abuse (DOA) have become of interest in exhaled breath particles (EBP). In this study, a liquid chromatography - tandem mass spectrometry (LC-MS/MS) method was developed and validated to analyze 28 DOA in 30L of EBP collected on a permeable polymer filter. After extraction, the chromatographic separation was achieved on a UPLC BEH phenyl column using a mobile phase consisting of methanol and water both containing 4mmol/L ammonium formate and 0...
October 9, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29056887/dietary-coconut-water-vinegar-for-improvement-of-obesity-associated-inflammation-in-high-fat-diet-treated-mice
#17
Nurul Elyani Mohamad, Swee Keong Yeap, Huynh Ky, Wan Yong Ho, Sook Yee Boo, Joelle Chua, Boon-Kee Beh, Shaiful Adzni Sharifuddin, Kamariah Long, Noorjahan Banu Alitheen
Obesity has become a serious health problem worldwide. Various types of healthy food, including vinegar, have been proposed to manage obesity. However, different types of vinegar may have different bioactivities. This study was performed to evaluate the anti-obesity and anti-inflammatory effects of coconut water vinegar on high-fat-diet (HFD)-induced obese mice. Changes in the gut microbiota of the mice were also evaluated. To induce obesity, C57/BL mice were continuously fed an HFD for 33 weeks. Coconut water vinegar (0...
2017: Food & Nutrition Research
https://www.readbyqxmd.com/read/29055248/simultaneous-quantification-of-direct-oral-anticoagulants-currently-used-in-anticoagulation-therapy
#18
Kathrin I Foerster, Andrea Huppertz, Oliver J Müller, Timolaos Rizos, Lisa Tilemann, Walter E Haefeli, Jürgen Burhenne
Direct oral anticoagulants (DOACs) are among the most effective options to prevent serious thromboembolic events in patients with atrial fibrillation. Coagulation assays are used to assess DOAC activity, but lack the possibility to quantify drugs with concurrent pharmacodynamic effect. We developed a selective multi-drug assay to analyze apixaban, betrixaban, dabigatran, edoxaban, edoxaban M4, and rivaroxaban with ultra-performance liquid chromatography coupled to tandem mass spectrometry (UPLC/MS/MS) in plasma fulfilling all requirements of the FDA und EMA guidelines for bioanalytical method validation...
October 16, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29055246/comparative-analysis-of-multiple-representative-components-in-the-herb-pair-astragali-radix-curcumae-rhizoma-and-its-single-herbs-by-uplc-qqq-ms
#19
Gang Yin, Xiaolan Cheng, Weiwei Tao, Yu Dong, Yong Bian, Wenhua Zang, Decai Tang
The herb-pair, Astragali Radix (AR) and Curcumae Rhizoma (CR), often occurs in traditional herbal prescriptions used for cancer treatment in Asian areas. In clinical application, the AR-CR herb pair was often produced by different preparation methods or with raw materials from different sources, which raised a challenge for quality control of the herb-pair medicines. In this paper, ultra high performance liquid chromatography coupled to triple quadrupole tandem mass spectrometry method (UPLC-QQQ-MS) was applied for the first time to simultaneously determine 17 main bioactive components for quality control of AR-CR herb pair...
October 14, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29055065/simultaneous-determination-of-usnic-diffractaic-evernic-and-barbatic-acids-in-rat-plasma-by-ultra-high-performance-liquid-chromatography-quadrupole-exactive-orbitrap-mass-spectrometry-and-its-application-to-pharmacokinetic-studies
#20
Hanxue Wang, Tao Yang, Xuemei Cheng, Sukfan Kwong, Chenghai Liu, Rui An, Guowen Li, Xinhong Wang, Changhong Wang
Usnea longissima Ach. (Usnea) has been used in pharmaceuticals, food, cosmetics. Evernic acid (EA), barbatic acid (BA), diffractaic acid (DA), and usnic acid (UA) are the most typical ingredients in U. longissima and exert a wide variety of biological functions. The study aim to develop a sensitive method for simultaneous analysis of EA, BA, DA, and UA in rat plasma and applied to pharmacokinetic studies after consumption of UA and ethanol extract from U. longissima (UE). The samples were separated on BEH C18 column by gradient elution with 0...
October 21, 2017: Biomedical Chromatography: BMC
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