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https://www.readbyqxmd.com/read/28522842/cryo-electron-microscopy-structure-of-the-macrobrachium-rosenbergii-nodavirus-capsid-at-7-angstroms-resolution
#1
Kok Lian Ho, Chare Li Kueh, Poay Ling Beh, Wen Siang Tan, David Bhella
White tail disease in the giant freshwater prawn Macrobrachium rosenbergii causes significant economic losses in shrimp farms and hatcheries and poses a threat to food-security in many developing countries. Outbreaks of Macrobrachium rosenbergii nodavirus (MrNV), the causative agent of white tail disease (WTD) are associated with up to 100% mortality rates. There are no interventions available to treat or prevent MrNV disease however. Here we show the structure of MrNV virus-like particles (VLPs) produced by recombinant expression of the capsid protein, using cryogenic electron microscopy...
May 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28494351/development-and-validation-of-a-sensitive-uplc-ms-ms-instrumentation-and-alkaline-nitrobenzene-oxidation-method-for-the-determination-of-lignin-monomers-in-wheat-straw
#2
Mengjing Zheng, Shubo Gu, Jin Chen, Yongli Luo, Wenqian Li, Jun Ni, Yong Li, Zhenlin Wang
A method to determine the lignin monomers (p-hydroxybenzaldehyde, vanillin and syringaldehyde) in plant cell wall of wheat internode was developed and validated using a high-throughput nitrobenzene oxidation step and ultra performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) for quantification. UPLC analyses were carried out using an reversed phase C18 column (ACQUITY UPLC BEH, 1.7μm, 2.1×100mm) and gradient elution with water and acetonitrile. This method was completely validated in terms of analyzing speed, linearity, sensitivity, limits of detection (LODs) and limits of quantification (LOQs)...
April 23, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28486433/human-indoor-exposure-to-airborne-halogenated-flame-retardants-influence-of-airborne-particle-size
#3
Mark J La Guardia, Erika D Schreder, Nancy Uding, Robert C Hale
Inhalation of halogenated flame-retardants (HFRs) released from consumer products is an important route of exposure. However, not all airborne HFRs are respirable, and thus interact with vascular membranes within the gas exchange (alveolar) region of the lung. HFRs associated with large (>4 µm), inhalable airborne particulates are trapped on the mucosal lining of the respiratory tract and then are expelled or swallowed. The latter may contribute to internal exposure via desorption from particles in the digestive tract...
May 9, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28485018/fast-and-parallel-determination-of-pcb-77-and-pcb-180-in-plasma-using-ultra-performance-liquid-chromatography-uplc-with-diode-array-detection-dad-a-pharmacokinetic-study-in-swiss-albino-mouse
#4
N Ramanujam, M Sivaselvakumar, S Ramalingam
A simple, sensitive and reproducible ultra-performance liquid chromatography (UPLC) method has been developed and validated for simultaneous estimation of PCB 77 and PCB 180 in mouse plasma. The sample preparation was performed by simple liquid-liquid extraction technique. The analytes were chromatographed on a Waters Acquity H class UPLC system using isocratic mobile phase conditions at a flow rate of 0.3 mL/min and Acquity UPLC BEH shield RP18 column maintained at 35 °C temperature. Quantification was performed on a photodiode array detector set at 215 nm and PCB 101 was used as internal standard (IS)...
May 8, 2017: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/28475237/production-of-zebrafish-cardiospheres-and-cardiac-progenitor-cells-in-vitro-and-three-dimensional-culture-of-adult-zebrafish-cardiac-tissue-in-scaffolds
#5
Wendy R Zeng, Siew-Joo Beh, Robert J Bryson-Richardson, Pauline M Doran
The hearts of adult zebrafish (Danio rerio) are capable of complete regeneration in vivo even after major injury, making this species of particular interest for understanding the growth and differentiation processes required for cardiac tissue engineering. To date, little research has been carried out on in vitro culture of adult zebrafish cardiac cells. In this work, progenitor-rich cardiospheres suitable for cardiomyocyte differentiation and myocardial regeneration were produced from adult zebrafish hearts...
May 5, 2017: Biotechnology and Bioengineering
https://www.readbyqxmd.com/read/28460742/revisiting-an-old-disease-risk-factors-for-bovine-enzootic-haematuria-in-the-kingdom-of-bhutan
#6
Arata Hidano, Basant Sharma, Karma Rinzin, Narapati Dahal, Kinzang Dukpa, Mark A Stevenson
Bovine enzootic haematuria (BEH) is a debilitating disease of cattle caused by chronic ingestion of bracken fern. Control of BEH is difficult when bracken fern is abundant and fodder resources are limited. To fill a significant knowledge gap on modifiable risk factors for BEH, we conducted a case-control study to identify cattle management practices associated with BEH in the Bhutanese cattle population. A case-control study involving 16 of the 20 districts of Bhutan was carried out between March 2012 and June 2014...
May 1, 2017: Preventive Veterinary Medicine
https://www.readbyqxmd.com/read/28451436/loading-conditions-in-the-spine-hip-and-knee-during-different-executions-of-back-extension-exercises
#7
Florian Schellenberg, Nicole Schmid, Ramona Häberle, Nicole Hörterer, William R Taylor, Silvio Lorenzetti
BACKGROUND: Back extension (BE) is a strength exercise for training the dorsal trunk and hip muscles. To optimise training recommendations that avoid overloading and possible injury, the aim of this study was to determine the loading conditions and the influence of different execution forms of BE on spine, hip and knee ranges of motion (RoMs), joint moments and muscle activity. METHODS: The kinematics, kinetics and muscle activity (EMG) of two execution types (BEh: dynamic hip, BEs: dynamic spine) and two versions (one-legged and two-legged) of BE were measured in 16 subjects...
2017: BMC Sports Science, Medicine and Rehabilitation
https://www.readbyqxmd.com/read/28430855/cancer-immunotherapy-trial-registrations-increase-exponentially-but-chronic-immunosuppressive-glucocorticoid-therapy-may-compromise-outcomes
#8
C M Connell, S Raby, I Beh, T Flint, E Williams, D T Fearon, D I Jodrell, T Janowitz
No abstract text is available yet for this article.
April 14, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/28423776/application-of-correspondence-analysis-to-graphically-investigate-associations-between-foods-and-eating-locations
#9
Andrew N Chapman, Eric J Beh, Luigi Palla
This paper presents the application of correspondence analysis (CA) for investigating associations using confidence regions (CRs) with a focus on facilitating mining the data and hypothesis generation. We study the relationship between locations and "less-healthy" food consumption by UK teenagers. CA allows for a quick visual inspection of the various association structures that exist between the categories of cross-classified variables in large datasets derived with varying study designs. The hypotheses generated by the visual display can then be independently tested using suitable regression models...
2017: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/28414972/an-lc-ms-ms-method-for-quantification-of-ac0010-a-novel-mutant-selective-epidermal-growth-factor-receptor-egfr-inhibitor-and-its-metabolites-in-human-plasma-and-the-application-to-a-pharmacokinetic-study
#10
Lu Wang, Xin Zheng, Weicong Wang, Pei Hu, Ji Jiang
AC0010 is an irreversible, mutant-selective EGFR inhibitor that effectively inhibits EGFR active and T790M resistance mutations in non-small cell lung cancer (NSCLC). A sensitive ultra-performance liquid chromatography - tandem mass spectrometry (UPLC-MS/MS) method was developed and fully validated for determining AC0010 and its metabolites in human plasma. The samples were purified by solid-phase extraction (SPE) columns and separated on a BEH C18 column. Electrospray ionization (ESI) in positive ion mode and multiple reaction monitoring (MRM) were used to monitor the ion transitions of AC0010 (m/z 488→257) and its metabolites M1 (m/z 474→403), M2 (m/z 504→487), M4 (m/z 434→377), M7 (m/z 490→405), MII-1 (m/z 651→434) and MII-2 (m/z 609→434)...
March 28, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28403574/determination-of-artemisitene-in-rat-plasma-by-uplc-ms-ms-and-its-application-in-pharmacokinetics
#11
Lilan Wu, Yunshan Wu, Weiying Chen, Wen Zhou, Lipeng Tang, Ben Li, Bo Liu
RATIONALE: Artemisitene showed a wide variety of pharmacological activities, such as antioxidant protection in vitro and in vivo. It has been identified as a novel Nrf2 inducer. However, there is no report on an UPLC-MS/MS method to quantitate artemisitene in rat plasma and its application on pharmacokinetic profile study. METHODS: An ACQUITY UPLC(TM) BEH Symmetry ShieldRP18 column (1.7 µm, 2.1 mm × 100 mm) was used with a flow rate of 0.3 mL · min(-1) ...
April 12, 2017: Rapid Communications in Mass Spectrometry: RCM
https://www.readbyqxmd.com/read/28403317/attention-memory-visuoconstructive-and-executive-task-performance-in-adolescents-with-anxiety-disorders-a-case-control-community-study
#12
Rafaela Behs Jarros, Giovanni Abrahão Salum, Cristiano Tschiedel Belem da Silva, Rudineia Toazza, Natália Becker, Marilyn Agranonik, Jerusa Fumagalli de Salles, Gisele Gus Manfro
Objective: The aim of the present study was to assess children and adolescents with mild and severe anxiety disorders for their performance in attention, verbal episodic memory, working memory, visuoconstructive skills, executive functions, and cognitive global functioning and conduct comparative analyses with the performance of children free from anxiety disorders. Methods: Our sample comprised 68 children and adolescents aged 10 to 17 years (41 with current diagnoses of anxiety disorders and 27 controls) selected from a larger cross-sectional community sample of adolescents...
January 2017: Trends in Psychiatry and Psychotherapy
https://www.readbyqxmd.com/read/28398911/increased-epicardial-fat-thickness-in-sudden-death-from-stable-coronary-artery-atherosclerosis
#13
Belinda Fuller, Jack Garland, Sravan Anne, Raymond Beh, Dennis McNevin, Rexson Tse
BACKGROUND: Sudden death from stable coronary artery atherosclerosis (SCAA) is well recognized. However, individuals can have ischemic heart disease or coronary artery atherosclerosis but die of noncardiac causes. Recently, it has been recognized that increased epicardial fat is detrimental to normal heart function. We hypothesize that individuals who die of SCAA have increased epicardial fat. AIM: The aim of this study was to investigate whether there is an increase in epicardial fat in individuals who suddenly died of SCAA...
June 2017: American Journal of Forensic Medicine and Pathology
https://www.readbyqxmd.com/read/28392327/new-liquid-chromatography-tandem-mass-spectrometry-method-for-routine-tdm-of-vancomycin-in-patients-with-both-normal-and-impaired-renal-functions-and-comparison-with-results-of-polarization-fluoroimmunoassay-in-light-of-varying-creatinine-concentrations
#14
Hana Brozmanová, Ivana Kacířová, Romana Uřinovská, Pavel Šištík, Milan Grundmann
A new LC-MS/MS method with simple sample extraction and a relatively short period of vancomycin analysis for routine therapeutic drug monitoring was developed and validated. 50μL serum was precipitated using 20μL 33% trichloroacetic acid and 0.5mol/L NH4OH was added to increase pH before analysis. A RP BEH C18, 1.7μm, 2.1×50mm column maintained at 30°C and tobramycin as internal standard were used. Mass detection was performed in positive electrospray mode. The results obtained with LC-MS/MS method were correlated with an FPIA assay (Abbott AxSYM) using mouse monoclonal antibody...
April 7, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/28370149/determination-of-4-1-3-dioxo-1-3-dihydro-2h-isoindol-2-yl-n-4-ethoxyphenyl-methylidene-benzohydrazide-a-novel-anti-inflammatory-agent-in-biological-fluids-by-uplc-ms-ms-assay-development-validation-and-in-vitro-metabolic-stability-study
#15
Muzaffar Iqbal, Mashooq A Bhat, Mohammad Raish, Essam Ezzeldin
A thalidomide analogue, (4-(1,3-dioxo-1,3-dihydro-2H-isoindol- 2-yl)-N'-[(4-ethoxyphenyl) methylidene] benzohydrazide), has been identified as a promising broad spectrum anti-inflammatory agent in previous study. In this study, a sensitive and selective UPLC-MS/MS assay was developed and validated for its determination in rat plasma samples. The chromatographic separation was performed on Aquity BEH C18 column using mobile phase comprising of acetonitrile and 10 mM ammonium acetate in the ratio of 85:15, at flow rate of 0...
March 31, 2017: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/28365413/ultra-performance-liquid-chromatography-tandem-mass-spectrometry-for-determination-of-direct-acting-antiviral-drugs-in-human-liver-fine-needle-aspirates
#16
Andrew J Ocque, Colleen E Hagler, Robin DiFrancesco, Gene D Morse, Andrew H Talal
An ultra-performance liquid chromatography with triple quadrupole mass spectrometry method was developed and validated for the determination of direct acting antiviral drug concentrations in human liver fine needle aspirates. Liver fine needle aspirate (FNA) biopsy samples were homogenized in acetonitrile to stabilize the analytes and precipitate protein. The acetonitrile supernatants were diluted with internal standards and mobile phase. Separation was achieved with a Waters Acquity BEH C18 column (50×2.1mm, 1...
March 24, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28363092/vehicles-as-outdoor-bfr-sources-evidence-from-an-investigation-of-bfr-occurrence-in-road-dust
#17
Zhiguo Cao, Leicheng Zhao, Jiangmeng Kuang, Qiaoying Chen, Guifen Zhu, Kunlun Zhang, Shihua Wang, Peipei Wu, Xin Zhang, Xuefeng Wang, Stuart Harrad, Jianhui Sun
The distribution of brominated flame retardants (BFRs) including ∑8PBDEs, DBDPE, BTBPE, EH-TBB, BEH-TEBP and PBEB in road dust (RD) collected in Xinxiang, China was characterized. Analysis of RD samples indicated that the BFR abundance declined as traffic density decreased, with total mean levels of 292, 184, 163, 104 and 70 ng g(-1) dust at sites from traffic intersections, main roads, collector streets, bypasses and parks, respectively. A possible explanation for this phenomenon is that the majority of BFRs may be emitted from the interior of vehicles via their ventilation systems...
July 2017: Chemosphere
https://www.readbyqxmd.com/read/28352153/development-of-erythropoietin-receptor-targeted-drug-delivery-system-against-breast-cancer-using-tamoxifen-loaded-nanostructured-lipid-carriers
#18
Chaw Yee Beh, Chee Wun How, Jhi Biau Foo, Jia Ning Foong, Gayathri Thevi Selvarajah, Abdullah Rasedee
Tamoxifen (TAM) has been used in the treatment of breast cancers and is supplemented with erythropoietin (EPO) to alleviate the cancer-related anemia. The purported deleterious effects caused by the use of EPO with chemotherapeutic agents in the treatment of cancer-related anemia vary across studies and remain controversial. The use of nanoparticles as a drug delivery system has the potential to improve the specificity of anticancer drugs. In this study, we simultaneously incorporated two pharmacological active ingredients in one nanocarrier to develop EPO-conjugated TAM-loaded lipid nanoparticles (EPO-TAMNLC), a targeted delivery system, to enhance the cytotoxic activity while reducing the side effects of the ingredients...
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/28337929/a-public-health-approach-in-responding-to-the-spread-of-helium-suicide-in-hong-kong
#19
Paul S F Yip, Qijin Cheng, Shu-Sen Chang, Esther Sze Tsai Lee, Chui-Shan Carmen Lai, Feng Chen, Yik-Wa Frances Law, T M Eric Cheng, Sau Mee Chiu, Y L Jeff Tse, Ka-Wai Raymond Cheung, Man-Li Tse, Peter R Morgan, Philip Beh
BACKGROUND: The use of the helium suicide method has been increasing in popularity in Hong Kong since 2012. We have learned a valuable lesson in curbing the spread of charcoal burning (CB) suicide in the past 15 years and hope to prevent the helium suicide method from taking off in the community. AIMS: To document what actions have been taken to contain the spread of the helium suicide method and review the preliminary impact of these actions. METHOD: We adopted a public health approach by engaging stakeholders from multiple sectors, including the police force, the fire services department, coroners, pathologists, mass media, and online media outlets...
March 24, 2017: Crisis
https://www.readbyqxmd.com/read/28335995/assessment-of-dietary-exposure-to-organohalogen-contaminants-legacy-and-emerging-flame-retardants-in-a-norwegian-cohort
#20
Fuchao Xu, Joo-Hui Tay, Adrian Covaci, Juan Antonio Padilla-Sánchez, Eleni Papadopoulou, Line Småstuen Haug, Hugo Neels, Ulla Sellström, Cynthia A de Wit
Polychlorinated biphenyls (PCBs), organochlorine pesticides (OCPs), polybrominated diphenyl ethers (PBDEs), emerging halogenated flame retardants (EHFRs) and organophosphate flame retardants (PFRs) were detected in 24h duplicate diet samples from a Norwegian cohort (n=61), with concentrations ranging from <method limit of quantification (MLQ)-0.64ng/g ww, <MLQ-0.70ng/g ww, <MLQ-0.93ng/g ww, <MLQ-0.14ng/g ww, and <MLQ-150ng/g ww, respectively. All studied contaminants were detected in the duplicate diet samples with detection frequencies (DF) ranging from 1...
March 20, 2017: Environment International
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