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https://www.readbyqxmd.com/read/28337929/a-public-health-approach-in-responding-to-the-spread-of-helium-suicide-in-hong-kong
#1
Paul S F Yip, Qijin Cheng, Shu-Sen Chang, Esther Sze Tsai Lee, Chui-Shan Carmen Lai, Feng Chen, Yik-Wa Frances Law, T M Eric Cheng, Sau Mee Chiu, Y L Jeff Tse, Ka-Wai Raymond Cheung, Man-Li Tse, Peter R Morgan, Philip Beh
BACKGROUND: The use of the helium suicide method has been increasing in popularity in Hong Kong since 2012. We have learned a valuable lesson in curbing the spread of charcoal burning (CB) suicide in the past 15 years and hope to prevent the helium suicide method from taking off in the community. AIMS: To document what actions have been taken to contain the spread of the helium suicide method and review the preliminary impact of these actions. METHOD: We adopted a public health approach by engaging stakeholders from multiple sectors, including the police force, the fire services department, coroners, pathologists, mass media, and online media outlets...
March 24, 2017: Crisis
https://www.readbyqxmd.com/read/28335995/assessment-of-dietary-exposure-to-organohalogen-contaminants-legacy-and-emerging-flame-retardants-in-a-norwegian-cohort
#2
Fuchao Xu, Joo-Hui Tay, Adrian Covaci, Juan Antonio Padilla-Sánchez, Eleni Papadopoulou, Line Småstuen Haug, Hugo Neels, Ulla Sellström, Cynthia A de Wit
Polychlorinated biphenyls (PCBs), organochlorine pesticides (OCPs), polybrominated diphenyl ethers (PBDEs), emerging halogenated flame retardants (EHFRs) and organophosphate flame retardants (PFRs) were detected in 24h duplicate diet samples from a Norwegian cohort (n=61), with concentrations ranging from <method limit of quantification (MLQ)-0.64ng/g ww, <MLQ-0.70ng/g ww, <MLQ-0.93ng/g ww, <MLQ-0.14ng/g ww, and <MLQ-150ng/g ww, respectively. All studied contaminants were detected in the duplicate diet samples with detection frequencies (DF) ranging from 1...
March 20, 2017: Environment International
https://www.readbyqxmd.com/read/28330482/development-of-a-model-of-saint-louis-encephalitis-infection-and-disease-in-mice
#3
Rafael Elias Marques, Juliana L Del Sarto, Rebeca P F Rocha, Giovanni F Gomes, Allysson Cramer, Milene A Rachid, Danielle G Souza, Maurício L Nogueira, Mauro M Teixeira
BACKGROUND: Flaviviruses are a genre of closely related viral pathogens which emerged in the last decades in Brazil and in the world. Saint (St.) Louis encephalitis virus (SLEV) is a neglected flavivirus that can cause a severe neurological disease that may lead to death or sequelae. St. Louis encephalitis pathogenesis is poorly understood, which hinders the development of specific treatment or vaccine. METHODS: To address this problem, we developed a model of SLEV infection in mice to study mechanisms involved in the pathogenesis of severe disease...
March 22, 2017: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/28328039/reduction-of-metal-adducts-in-oligonucleotide-mass-spectra-in-ion-pair-reversed-phase-chromatography-mass-spectrometry-analysis
#4
Robert E Birdsall, Martin Gilar, Henry Shion, Ying Qing Yu, Weibin Chen
RATIONALE: Electrospray ionization mass spectrometry (ESI-MS)-based techniques commonly used in oligonucleotide analyses are known to be sensitive to alkali metal adduct formation. Adducts directly impact the sensitivity of MS-based analyses as the available charge is distributed across the parent peak and adduct(s). The current study systematically evaluated common liquid chromatography (LC) components in LC/ESI-MS configurations used in oligonucleotide analysis to identify metal adduct contributions from LC instrumentation...
July 30, 2016: Rapid Communications in Mass Spectrometry: RCM
https://www.readbyqxmd.com/read/28319741/influence-of-sampling-approach-on-concentrations-of-legacy-and-novel-brominated-flame-retardants-in-indoor-dust
#5
Layla Salih Al-Omran, Stuart Harrad
The study investigates the impact of sampling method on the concentrations of PBDEs (BDE-28, BDE-47, BDE-99, BDE-100, BDE-153, BDE-154, BDE-183, and BDE-209) and NBFRs (PBEB, EH-TBB, BEH-TEBP, BTBPE and DBDPE) in indoor dust. A total of 36 dust samples were collected from 12 homes in Birmingham, UK (3 samples per home comprising researcher collected dust - both RCD from the living room (RCDL) and bedroom (RCDB), with an additional householder vacuum dust sample - HHVD). BDE-209 was the predominant compound, with average concentrations of 2642, 2336 and 2634 ng/g in RCDL, RCDB and HHVD respectively...
February 22, 2017: Chemosphere
https://www.readbyqxmd.com/read/28314201/inhibition-of-mirna-212-132-improves-the-reprogramming-of-fibroblasts-into-induced-pluripotent-stem-cells-by-de-repressing-important-epigenetic-remodelling-factors
#6
Nils Pfaff, Steffi Liebhaber, Selina Möbus, Abbas Beh-Pajooh, Jan Fiedler, Angelika Pfanne, Axel Schambach, Thomas Thum, Tobias Cantz, Thomas Moritz
MicroRNAs (miRNAs) repeatedly have been demonstrated to play important roles in the generation of induced pluripotent stem cells (iPSCs). To further elucidate the molecular mechanisms underlying transcription factor-mediated reprogramming we have established a model, which allows for the efficient screening of whole libraries of miRNAs modulating the generation of iPSCs from murine embryonic fibroblasts. Applying this model, we identified 14 miRNAs effectively inhibiting iPSC generation, including miR-132 and miR-212...
March 7, 2017: Stem Cell Research
https://www.readbyqxmd.com/read/28306207/development-and-validation-of-a-uhplc-ms-ms-method-for-the-simultaneous-determination-of-five-bioactive-flavonoids-in-rat-plasma-and-comparative-pharmacokinetic-study-after-oral-administration-of-xiaochaihu-tang-and-three-compatibilities
#7
Yunhai Bo, Lijuan Wang, Xiao Wu, Longshan Zhao, Jingyu Yang, Zhili Xiong, Chunfu Wu
An accurate, rapid and reliable ultra high performance liquid chromatography with tandem mass spectrometry method was developed and validated for the simultaneous determination of baicalin, wogonoside, baicalein, wogonin and oroxylinA in rat plasma. Then, the stability of baicalin and baicalein in the preparation of plasma sample was systematically investigated. The Waters BEH C18 column was used with a gradient mobile phase system of acetonitrile and water containing 0.1% formic acid. The analytes were detected in the multiple reaction monitoring mode with positive electrospray ionization...
March 17, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/28304241/wireless-teleophthalmology-a-novel-low-cost-flexible-network-architecture-and-its-performance-evaluation-for-remote-eye-care-solutions
#8
Shashwat Pathak, Basant Kumar
INTRODUCTION: This article proposes a novel, cost-effective, flexible, and easy-to-deploy wireless teleophthalmology network architecture and performance evaluation for its potential use in remote areas. This study has used practical telecommunication standards, which is widely deployed throughout India. METHODS: In the proposed scenario, patient's eye images are obtained using a specified imaging modality, and then sent to a server at the primary eye care centre (PECC) using ZigBee a short-range wireless network...
March 17, 2017: Telemedicine Journal and E-health: the Official Journal of the American Telemedicine Association
https://www.readbyqxmd.com/read/28303226/simultaneous-determination-of-14-active-constituents-of-shengjiang-xiexin-decoction-using-ultrafast-liquid-chromatography-coupled-with-electrospray-ionization-tandem-mass-spectrometry
#9
Gang Peng, Huanyu Guan, Xiaoming Wang, Yue Shi
An effective herbal medicinal prescription of Shengjiang Xiexin decoction (SXD) was used in treating the inflammatory bowel disease in clinic. In this study, an ultrafast liquid chromatography-tandem mass spectrometry (UFLC-MS/MS) method was developed to separate and to simultaneously determine 14 major active ingredients in SXD. Chromatographic separation was successfully accomplished on an Acquity BEH C18 (100 mm×2.1 mm, 1.7 μm) column using gradient elution with 0.1% (v/v) formic acid water (A) and 0...
March 2017: Acta Pharmaceutica Sinica. B
https://www.readbyqxmd.com/read/28301880/fast-and-green-co2-based-extraction-isolation-and-quantification-of-phenolic-styrax-constituents
#10
Johanna Scheuba, Valerie-Katharina Wronski, Judith M Rollinger, Ulrike Grienke
In this study the first supercritical fluid based protocol for the extraction, analysis, and isolation of six polar compounds, i.e., o-vanillin (1), styracin (2), vanillin (3), trans-cinnamic acid (4), vanillic acid (5), and shikimic acid (6), was developed. First, eight styrax resin products (R1-R8) obtained from various Liquidambar tree species, which are known to contain compounds 2-6, were extracted with a 1 : 1 mixture of supercritical CO2 and EtOH. Within 4 minutes, the compounds were successfully baseline separated on an Acquity UPC(2) BEH 2-EP (3...
March 16, 2017: Planta Medica
https://www.readbyqxmd.com/read/28301148/synthesis-and-photobiological-activity-of-ru-ii-dyads-derived-from-pyrrole-2-carboxylate-thionoesters
#11
Deborah A Smithen, Huimin Yin, Michael H R Beh, Marc Hetu, T Stanley Cameron, Sherri A McFarland, Alison Thompson
The synthesis and characterization of a series of heteroleptic ruthenium(II) dyads derived from pyrrole-2-carboxylate thionoesters are reported. Ligands bearing a conjugated thiocarbonyl group were found to be more reactive toward Ru(II) complexation compared to analogous all-oxygen pyrrole-2-carboxylate esters, and salient features of the resulting complexes were determined using X-ray crystallography, electronic absorption, and NMR spectroscopy. Selected complexes were evaluated for their potential in photobiological applications, whereupon all compounds demonstrated in vitro photodynamic therapy effects in HL-60 and SK-MEL-28 cells, with low nanomolar activities observed, and exhibited some of the largest photocytotoxicity indices to date (>2000)...
March 16, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28288784/development-and-validation-of-a-measurement-procedure-based-on-ultra-high-performance-liquid-chromatography-tandem-mass-spectrometry-for-simultaneous-measurement-of-%C3%AE-lactam-antibiotic-concentration-in-human-plasma
#12
Raül Rigo-Bonnin, Alba Ribera, Ariadna Arbiol-Roca, Sara Cobo-Sacristán, Ariadna Padullés, Òscar Murillo, Evelyn Shaw, Rosa Granada, Xosé L Pérez-Fernández, Fe Tubau, Pedro Alía
BACKGROUND: The administration of β-lactam antibiotics in continuous infusion could let optimize the pharmacokinetic/pharmacodynamic parameters, especially in the treatment of serious bacterial infections. In this context, and also due to variability in their plasmatic concentrations, therapeutic drug monitoring (TDM) may be useful to optimize dosing and, therefore, be useful for the clinicians. MATERIAL AND METHODS: We developed and validated a measurement procedure based on ultra-high performance liquid chromatography-tandem mass spectrometry for simultaneous measurement of amoxicillin, ampicillin, cloxacillin, piperacillin, cefepime, ceftazidime, cefuroxime, aztreonam and meropenem concentrations in plasma...
March 10, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/28287712/antimicrobial-activity-of-%C3%AE%C2%B5-poly-l-lysine-after-forming-a-water-insoluble-complex-with-an-anionic-surfactant
#13
Kazunori Ushimaru, Yoshimitsu Hamano, Hajime Katano
ε-Poly-l-lysine (ε-PL) is one of the few homopoly(amino-acid)s occurring in nature. ε-PL, which possesses multiple amino groups, is highly soluble in water, where it forms the antimicrobial polycationic chain (PL(n+)). Although the high water-solubility is advantageous for the use of ε-PL as a food preservative, it has limited the applicability of ε-PL as a biopolymer plastic. Here, we report on the preparation and availability of a water-insoluble complex formed with PL(n+) and an anionic surfactant, bis(2-ethylhexyl) sulfosuccinate (BEHS(-), is also commercialized as AOT) anion...
March 24, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28285073/development-of-an-uplc-ms-ms-method-for-quantification-of-avitinib-ac0010-and-its-five-metabolites-in-human-cerebrospinal-fluid-application-to-a-study-of-the-blood-brain-barrier-penetration-rate-of-non-small-cell-lung-cancer-patients
#14
Weicong Wang, Xin Zheng, Hanping Wang, Lu Wang, Ji Jiang, Pei Hu
Avitinib (AC0010) is a mutant-selective epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKI), designed to be a targeted therapeutic agent for non-small cell lung cancer (NSCLC) patients harboring EGFR active and T790M resistant mutations. A rapid and sensitive ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method was developed and validated for the determination of Avitinib and its five metabolites (M1, M2, M4, M7, MII-6) in human cerebrospinal fluid (CSF). The samples were purified by protein precipitation and separated on a BEH C18 column (2...
March 4, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28273367/lc-ms-ms-method-for-simultaneous-determination-of-flavonoids-and-physalins-in-rat-plasma-application-to-pharmacokinetic-study-after-oral-administration-of-physalis-alkekengi-var-franchetii-chinese-lantern-extract
#15
Yaqing Guo, Hongxia Liu, Liqin Ding, Mahmood Oppong, Guixiang Pan, Feng Qiu
A rapid and sensitive liquid chromatography with tandem mass spectrometry (LC-MS/MS) method was developed and validated for the simultaneous determination of luteolin, luteolin-7-O-glucopyranoside, physalin A, physalin D and physalin L in rat plasma. Scutellarein and dexamethasone were used as the internal standards (IS). Plasma samples were prepared by liquid-liquid extraction with ethyl acetate. The five constituents were separated on an Acquity UPLC BEH C18 column (100 mm × 2.1 mm, 1.7 µm). A gradient elution procedure was used with acetonitrile(A) - 0...
March 8, 2017: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/28260629/uplc-esi-ms-ms-study-of-the-effect-of-green-tea-extract-on-the-oral-bioavailability-of-erlotinib-and-lapatinib-in-rats-potential-risk-of-pharmacokinetic-interaction
#16
Hadir M Maher, Nourah Z Alzoman, Shereen M Shehata, Ashwag O Abahussain
Green tea (GT) is one of the most consumed beverages worldwide. Tyrosine kinase inhibitors (TKIs) belong to the oral targeted therapy that gained much interest in oncology practice, among which are erlotinib (ERL) and lapatinib (LAP). Since green tea polyphenols (GTP) are known to be inhibitors of receptor tyrosine kinases, GTE could likely potentiate the anticancer effect of TKIs, but with a possibility of pharmacokinetic (PK) interaction with co-administered TKIs. In this study, the effect of GTE on the PK of ERL/LAP in rats was studied...
April 1, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28258972/design-of-a-mechanism-for-converting-the-energy-of-knee-motions-by-using-electroactive-polymers
#17
Pascal Armbruster, Yannick Oster, Marcel Vogt, Christian Pylatiuk
Harvesting energy from human body motions has become a promising option to prolong battery life for powering medical devices for autonomy. Up to now, different generating principles including dielectric electroactive polymers (DEAPs) have been suggested for energy conversion. However, there is a lack of mechanisms that are specifically designed to convert energy with DEAPs. In a proof of concept study, a mechanical system was designed for stretching DEAPs in those phases of the gait cycle, in which the muscles mainly perform negative work...
March 4, 2017: Biomedizinische Technik. Biomedical Engineering
https://www.readbyqxmd.com/read/28256254/an-enhanced-targeted-identification-strategy-for-the-selective-identification-of-flavonoid-o-glycosides-from-carthamus-tinctorius-by-integrating-offline-two-dimensional-liquid-chromatography-linear-ion-trap-orbitrap-mass-spectrometry-high-resolution-diagnostic
#18
Chang-Liang Yao, Wen-Zhi Yang, Wei Si, Yao Shen, Nai-Xia Zhang, Hua-Li Chen, Hui-Qin Pan, Min Yang, Wan-Ying Wu, De-An Guo
Targeted identification of potentially bioactive molecules from herbal medicines is often stymied by the insufficient chromatographic separation, ubiquitous matrix interference, and pervasive isomerism. An enhanced targeted identification strategy is presented and validated by the selective identification of flavonoid O-glycosides (FOGs) from Carthamus tinctorius. It consists of four steps: (i) enhanced separation and detection by offline two-dimensional liquid chromatography/LTQ-Orbitrap MS (offline 2D-LC/LTQ-Orbitrap MS) using collision-induced dissociation (CID) and high-energy C-trap dissociation (HCD); (ii) improved identification of the major aglycones by acid hydrolysis and LC-SPE-NMR; (iii) simplified spectral elucidation by high-resolution diagnostic product ions/neutral loss filtering; and (iv) more convincing structural identification by matching an in-house library...
March 31, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28252299/multiconfiguration-self-consistent-field-study-on-formonitrile-imine-and-n-substituted-nitrile-imines-hcn2-r-energy-component-analysis-of-the-pseudo-jahn-teller-effect
#19
Azumao Toyota, Takashi Muramatsu, Shiro Koseki
Stable geometrical structures for formonitrile imine (1) and N-substituted nitrile imines HCN2-R (R = Li, BeH, BH2, CH3, CN, CCH, C6H5, NH2, OH, and F) (2-11) were examined by using the multiconfiguration self-consistent-field (MCSCF) method followed by second-order configuration interaction (SOCI) calculations and second-order multiconfiguration quasi-degenerate perturbation theory (MCQDPT2) calculations, together with the aug-cc-pVTZ basis sets. The results show that 1 suffers a pseudo-Jahn-Teller (JT) distortion from a linear C∞v structure to a C1 structure via a planar bent Cs structure...
March 14, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/28245598/a-uplc-ms-ms-method-for-simultaneous-determination-of-free-and-total-forms-of-a-phenolic-acid-and-two-flavonoids-in-rat-plasma-and-its-application-to-comparative-pharmacokinetic-studies-of-polygonum-capitatum-extract-in-rats
#20
Yong Huang, Hui-Yuan Sun, Xiao-Li Qin, Yong-Jun Li, Shang-Gao Liao, Zi-Peng Gong, Yuan Lu, Yong-Lin Wang, Ai-Min Wang, Yan-Yu Lan, Lin Zheng
The principal active constituents of Polygonum capitatum are phenolic acids and flavonoids, such as gallic acid, quercitrin, and quercetin. The aim of this study was to develop and validate a method to determine the three constituents and the corresponding conjugated metabolites of Polygonum capitatum in vivo and to conduct pharmacokinetic studies on the herb, a well-known Miao medicinal plant in China. Gallic acid, quercitrin, and quercetin were analysed by ultra-performance liquid chromatography-electrospray ionization-tandem mass spectrometry (UPLC-ESI-MS/MS)...
February 25, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
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