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https://www.readbyqxmd.com/read/29236034/gastric-emptying-and-gastrointestinal-transit-compared-among-native-and-hydrolyzed-whey-and-casein-milk-proteins-in-an-aged-rat-model
#1
Julie E Dalziel, Wayne Young, Catherine M McKenzie, Neill W Haggarty, Nicole C Roy
Little is known about how milk proteins affect gastrointestinal (GI) transit, particularly for the elderly, in whom digestion has been observed to be slowed. We tested the hypothesis that GI transit is faster for whey than for casein and that this effect is accentuated with hydrolysates, similar to soy. Adult male rats (18 months old) were fed native whey or casein, hydrolyzed whey (WPH) or casein (CPH), hydrolyzed blend (HB; 60% whey:40% casein), or hydrolyzed soy for 14 days then treated with loperamide, prucalopride, or vehicle-control for 7 days...
December 13, 2017: Nutrients
https://www.readbyqxmd.com/read/29232851/a-novel-prebiotic-blend-product-prevents-irritable-bowel-syndrome-in-mice-by-improving-gut-microbiota-and-modulating-immune-response
#2
Qian Chen, Yiping Ren, Jihong Lu, Mark Bartlett, Lei Chen, Yan Zhang, Xiaokui Guo, Chang Liu
Irritable bowel syndrome (IBS) is the most common functional gastrointestinal disorder yet it still lacks effective prevention therapies. The aim of this study is to determine whether a novel prebiotic blend (PB) composed of fructo-oligosaccharide (FOS), galactooligosaccharide (GOS), inulin and anthocyanins could be effective in preventing the development of IBS. We explored the possible mechanisms both in animal and in cells. Post-infectious IBS models in C57BL/6 mice were established and were pretreated with the PB, PB and probiotic strains 8 weeks in advance of infection...
December 9, 2017: Nutrients
https://www.readbyqxmd.com/read/29077888/effects-of-direct-fed-microorganisms-and-enzyme-blend-co-administration-on-intestinal-bacteria-in-broilers-fed-diets-with-or-without-antibiotics
#3
T E Askelson, C A Flores, S L Dunn-Horrocks, Y Dersjant-Li, K Gibbs, A Awati, J T Lee, T Duong
Direct-fed microorganisms (DFM) and exogenous enzymes have been demonstrated to improve growth performance in poultry and are potentially important alternatives to antibiotic growth promoters (AGP). We investigated the administration of a feed additive composed of a DFM product containing spores of 3 Bacillus amyloliquefaciens strains and an enzyme blend of endo-xylanase, α-amylase, and serine-protease in diets with or without sub-therapeutic antibiotics in broiler chickens over a 42-d growth period. Evaluation of growth performance determined feed efficiency of broiler chickens which were administered the feed additive was comparable to those fed a diet containing AGPs...
October 25, 2017: Poultry Science
https://www.readbyqxmd.com/read/29072162/impact-of-homogenization-of-pasteurized-human-milk-on-gastric-digestion-in-the-preterm-infant-a-randomized-controlled-trial
#4
Samira C de Oliveira, Amandine Bellanger, Olivia Ménard, Patrick Pladys, Yann Le Gouar, Gwénaële Henry, Emelyne Dirson, Florence Rousseau, Frédéric Carrière, Didier Dupont, Claire Bourlieu, Amélie Deglaire
BACKGROUND & AIMS: It has been suggested that homogenization of Holder-pasteurized human milk (PHM) could improve fat absorption and weight gain in preterm infants, but the impact on the PHM digestive kinetics has never been studied. Our objective was to determine the impact of PHM homogenization on gastric digestion in preterm infants. METHODS: In a randomized controlled trial, eight hospitalized tube-fed preterm infants were their own control to compare the gastric digestion of PHM and of homogenized PHM (PHHM)...
August 2017: Clinical Nutrition ESPEN
https://www.readbyqxmd.com/read/28969447/beneficial-effects-of-a-probiotic-blend-on-gastrointestinal-side-effects-induced-by-leflunomide-and-amlodipine-in-a-rat-model
#5
S-C Song, Y-M An, J-H Shin, M-J Chung, J-G Seo, E Kim
Patients with metabolic disorders frequently suffer from side effects induced by long-term oral medications. The present study using a rat model system indicated that leflunomide (LF) and amlodipine (AMD), the active ingredients contained in the medications for rheumatoid arthritis and hypertension, respectively, appeared to induce various bowel problems including constipation and inflammation. In the small and large intestine, LF increased the expression of tumour necrosis factor (TNF)-α, interleukin (IL)-1β, and IL-6 compared to the null control and AMD increased the expression of both TNF-α and IL-1β, although its effect on IL-6 was only increased in the large intestine...
October 3, 2017: Beneficial Microbes
https://www.readbyqxmd.com/read/28821042/chemical-and-biological-properties-of-the-novel-exopolysaccharide-produced-by-a-probiotic-strain-of-bifidobacterium-longum
#6
Rosanna Inturri, Antonio Molinaro, Flaviana Di Lorenzo, Giovanna Blandino, Barbara Tomasello, Claudio Hidalgo-Cantabrana, Cristina De Castro, Patricia Ruas-Madiedo
Bifidobacterium longum W11 is a commercialized probiotic that has an exopolysaccharide (EPS) layer covering its surface which could play a role in the beneficial properties attributed to the strain; thus, we have carried out chemical and biological analyses of this polymer. The eps cluster putatively involved in the polymer synthesis presented a unique structural organization not previously reported in bifidobacteria. B. longum W11 produced a complex polysaccharide blend with the main component composed of glucose and galactose...
October 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28771735/polyphenol-content-in-vitro-bioaccessibility-and-antioxidant-capacity-of-widely-consumed-beverages
#7
Gema Baeza, Beatriz Sarriá, Laura Bravo, Raquel Mateos
BACKGROUND: Beverages prepared from antioxidant-rich plants are sources of polyphenols, the bioactivity of which depends on bioaccessibility in the gastrointestinal tract. This work evaluated the polyphenol content and antioxidant capacity of widely consumed beverages such as chamomile tea, yerba mate, a coffee blend (65% roasted: 35% green), and coffee-like substitutes such as chicory, malt and a soluble cereal mixture. Additionally, the bioaccessibility of the two beverages with the highest antioxidant capacity was evaluated using an in vitro digestion model...
August 3, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/28572941/effect-of-psyllium-and-gum-arabic-biopolymers-on-the-survival-rate-and-storage-stability-in-yogurt-of-enterococcus%C3%A2-duransiw3-encapsulated-in-alginate
#8
Yousef Nami, Babak Haghshenas, Ahmad Yari Khosroushahi
Different herbal biopolymers were used to encapsulate Enterococcus durans IW3 to enhance its storage stability in yogurt and subsequently its endurance in gastrointestinal condition. Nine formulations of encapsulation were performed using alginate (ALG), ALG-psyllium (PSY), and ALG-gum Arabic (GA) blends. The encapsulation efficiency of all formulations, tolerance of encapsulated E. durans IW3 against low pH/high bile salt concentration, storage lifetime, and release profile of cells in natural condition of yogurt were evaluated...
May 2017: Food Science & Nutrition
https://www.readbyqxmd.com/read/28550604/microencapsulation-of-%C3%AE-carotene-based-on-casein-guar-gum-blend-using-zeta-potential-yield-stress-phenomenon-an-approach-to-enhance-photo-stability-and-retention-of-functionality
#9
Deepika Thakur, Ashay Jain, Gargi Ghoshal, U S Shivhare, O P Katare
β-Carotene, abundant majorly in carrot, pink guava yams, spinach, kale, sweet potato, and palm oil, is an important nutrient for human health due to its scavenging action upon reactive free radicals wherever produced in the body. Inclusion of liposoluble β-carotene in foods and food ingredients is a challenging aspect due to its labile nature and low absorption from natural sources. This fact has led to the application of encapsulation of β-carotene to improve stability and bioavailability. The present work was aimed to fabricate microcapsules (MCs) of β-carotene oily dispersion using the complex coacervation technique with casein (CA) and guar gum (GG) blend...
May 26, 2017: AAPS PharmSciTech
https://www.readbyqxmd.com/read/28506328/the-effect-of-dietary-faba-bean-and-non-starch-polysaccharide-degrading-enzymes-on-the-growth-performance-and-gut-physiology-of-young-turkeys
#10
D Mikulski, J Juskiewicz, B Przybylska-Gornowicz, E Sosnowska, B A Slominski, J Jankowski, Z Zdunczyk
The aim of this study was to investigate the effect of dietary replacement of soya bean meal (SBM) with faba bean (FB) and a blend of non-starch polysaccharide (NSP) degrading enzymes on the gastrointestinal function, growth performance and welfare of young turkeys (1 to 56 days of age). An experiment with a 2×2 factorial design was performed to compare the efficacy of four diets: a SBM-based diet and a diet containing FB, with and without enzyme supplementation (C, FB, CE and FBE, respectively). In comparison with groups C, higher dry matter content and lower viscosity of the small intestinal digesta were noted in groups FB...
May 16, 2017: Animal: An International Journal of Animal Bioscience
https://www.readbyqxmd.com/read/28504991/tablet-e-logbooks-four-thousand-clinical-cases-and-complications-e-logged-by-14-nondoctor-anesthesia-providers-in-nepal
#11
Shristi Shah, Oliver Ross, Stephen Pickering, Stephen Knoble, Indra Rai
BACKGROUND: To meet the need for essential surgery across rural Nepal, anesthesia at district level is delivered by nondoctor anesthetists. They require support to maintain confidence and competence, and upgraded professional registration to secure their status. To meet these needs, a distance-blended learning course was pioneered and delivered. A core course requirement was to log all clinical cases; these were logged on a new e-logbook. METHODS: Fourteen nondoctor anesthesia providers working in 12 different districts across Nepal were enrolled in the 1-year course...
October 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28462499/incorporation-of-lipolysis-in-monolayer-permeability-studies-of-lipid-based-oral-drug-delivery-systems
#12
Tanmoy Sadhukha, Buddhadev Layek, Swayam Prabha
Lipid-based drug delivery systems, a well-tolerated class of formulations, have been evaluated extensively to enhance the bioavailability of poorly soluble drugs. However, it has been difficult to predict the in vivo performance of lipid dosage forms based on conventional in vitro techniques such as cell monolayer permeability studies because of the complexity of the gastrointestinal processing of lipid formulations. In the current study, we explored the feasibility of coupling Caco-2 and Madin-Darby canine kidney monolayer permeability studies with lipolysis, a promising in vitro technique to evaluate lipid systems...
May 1, 2017: Drug Delivery and Translational Research
https://www.readbyqxmd.com/read/28460954/microcapsules-loaded-with-the-probiotic-lactobacillus-paracasei-bgp-1-produced-by-co-extrusion-technology-using-alginate-shellac-as-wall-material-characterization-and-evaluation-of-drying-processes
#13
Marluci P Silva, Fabricio L Tulini, Marcela M Ribas, Manfred Penning, Carmen S Fávaro-Trindade, Denis Poncelet
Microcapsules containing Lactobacillus paracasei BGP-1 were produced by co-extrusion technology using alginate and alginate-shellac blend as wall materials. Sunflower oil and coconut fat were used as vehicles to incorporate BGP-1 into the microcapsules. The microcapsules were evaluated with regard the particle size, morphology, water activity and survival of probiotics after 60days of storage at room temperature. Fluidized bed and lyophilization were used to dry the microcapsules and the effect of these processes on probiotic viability was also evaluated...
November 2016: Food Research International
https://www.readbyqxmd.com/read/28402145/the-effect-of-ph-buffer-capacity-and-ionic-strength-on-quetiapine-fumarate-release-from-matrix-tablets-prepared-using-two-different-polymeric-blends
#14
Rania Hamed, Reem AlJanabi, Suhair Sunoqrot, Aiman Abbas
The objective of this study was to investigate the effect of the different physiological parameters of the gastrointestinal (GI) fluid (pH, buffer capacity, and ionic strength) on the in vitro release of the weakly basic BCS class II drug quetiapine fumarate (QF) from two once-a-day matrix tablet formulations (F1 and F2) developed as potential generic equivalents to Seroquel(®) XR. F1 tablets were prepared using blends of high and low viscosity grades of hydroxypropyl methylcellulose (HPMC K4M and K100LV, respectively), while F2 tablets were prepared from HPMC K4M and PEGylated glyceryl behenate (Compritol(®) HD5 ATO)...
August 2017: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/28245257/cross-linked-%C3%AE-cyclodextrin-and-carboxymethyl-cellulose-hydrogels-for-controlled-drug-delivery-of-acyclovir
#15
Nadia Shamshad Malik, Mahmood Ahmad, Muhammad Usman Minhas
To explore the potential role of polymers in the development of drug-delivery systems, this study investigated the use of β-cyclodextrin (β-CD), carboxymethyl cellulose (CMC), acrylic acid (AA) and N' N'-methylenebis-acrylamide (MBA) in the synthesis of hydrogels for controlled drug delivery of acyclovir (ACV). Different proportions of β-CD, CMC, AA and MBA were blended with each other to fabricate hydrogels via free radical polymerization technique. Fourier transform infrared spectroscopy (FTIR) revealed successful grafting of components into the polymeric network...
2017: PloS One
https://www.readbyqxmd.com/read/28161879/effect-of-inulin-on-the-viability-of-l-plantarum-during-storage-and-in-vitro-digestion-and-on-composition-parameters-of-vegetable-fermented-juices
#16
Estefanía Valero-Cases, María José Frutos
The prebiotic effect of different concentrations of inulin (0, 1 and 2%) on the growth and survival of Lactobacillus plantarum (LP) CECT 220 in blended carrot and orange juices was investigated after 24 h of fermentation, during 30 days of storage at 4 °C and through the phases of gastrointestinal digestion after different storage periods. Microbiological and chemical determinations were also carried out in all juices. The lactic fermentation increased the shelf life of the fermented juices with inulin...
June 2017: Plant Foods for Human Nutrition
https://www.readbyqxmd.com/read/27999889/noise-optimized-virtual-monoenergetic-dual-energy-computed-tomography-optimization-of-kiloelectron-volt-settings-in-patients-with-gastrointestinal-stromal-tumors
#17
Simon S Martin, Sophia Pfeifer, Julian L Wichmann, Moritz H Albrecht, Doris Leithner, Lukas Lenga, Jan-Erik Scholtz, Thomas J Vogl, Boris Bodelle
PURPOSE: The aim of this study was to evaluate the impact of a noise-optimized virtual monoenergetic imaging (VMI+) reconstruction technique on quantitative and qualitative image analysis in patients with gastrointestinal stromal tumors (GISTs) at dual-energy computed tomography (DECT) of the abdomen. METHODS: Forty-five DECT datasets of 21 patients (14 men; 63.7 ± 9.2 years) with GISTs were reconstructed with the standard linearly blended (M_0.6) and VMI+ and traditional virtual monoenergetic (VMI) algorithm in 10-keV increments from 40 to 100 keV...
March 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/27818241/poly-vinyl-acetate-and-ammonio-methacrylate-copolymer-as-unconventional-polymer-blends-increase-the-mechanical-robustness-of-hpmc-matrix-tablets
#18
R Ali, A Dashevsky, R Bodmeier
The objective was to investigate poly vinyl acetate (Kollicoat(®) SR 30 D) and ammonio methacrylate copolymer (Eudragit(®) RL 30 D) blends as coatings to increase the mechanical robustness of hydroxypropyl methylcellulose (HPMC) matrix tablets. Poly vinyl acetate (Kollicoat(®) SR 30 D - KSR) was selected for its flexibility and ammonio methacrylate copolymer (Eudragit(®) RL 30 D - ERL) because of its high permeability. Films based on KSR:ERL blends were prepared by casting or spraying aqueous dispersions of these polymers and were characterized by water uptake, dry mass loss and mechanical properties...
January 10, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/27718119/successful-colonoscopic-fecal-microbiota-transplantation-for-active-ulcerative-colitis-first-report-from-india
#19
Avnish Kumar Seth, Pawan Rawal, Ruchika Bagga, Priti Jain
Forty-four-year-old male with ulcerative colitis (UC) for 11 years reported frequent relapse despite daily sulfasalazine 4 g, azathioprine 125 mg, and rectal 5-aminosalicylic acid. Repeated use of corticosteroids led to cataract. At enrollment, he was passing eight stools a day with blood with a Mayo score of 9 (3+1+3+2). Stool was negative for ova/cysts/acid fast bacilli and Clostridium difficile toxin assay. Rectal biopsy showed cryptitis, crypt abscess, and crypt distortion with no inclusion bodies, and cytomegalovirus DNA was negative...
September 2016: Indian Journal of Gastroenterology: Official Journal of the Indian Society of Gastroenterology
https://www.readbyqxmd.com/read/27578252/orange-pomace-fibre-increases-a-composite-scoring-of-subjective-ratings-of-hunger-and-fullness-in-healthy-adults
#20
Honglin Dong, Laura J Sargent, Yianna Chatzidiakou, Caroline Saunders, Laura Harkness, Nicolas Bordenave, Ian Rowland, Jeremy P E Spencer, Julie A Lovegrove
Dietary fibre has been shown to increase subjective satiating ratings. However data from human trials has produced mixed results, possibly due to different types of fibre which have diverse physicochemical properties and gastrointestinal transit behaviour. The aim of study 1 was to investigate whether orange juice (OJ) with 5.5 g of added orange pomace fibre (OPF) was as satiating as whole orange (WO, chopped and blended to a puree/liquid) compared with OJ. Study 2 was to evaluate the dose-dependent satiating effect of OPF delivered in an orange-flavoured beverage...
December 1, 2016: Appetite
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