keyword
https://read.qxmd.com/read/38536427/-single-cut-derotational-osteotomy-of-the-distal-femur-for-correction-of-torsion-and-frontal-axis
#21
REVIEW
Florian B Imhoff, Mathieu Trierweiler
OBJECTIVE: A rotational osteotomy requires a complete cut of the bone in order to correct maltorsion. An additional correction of the frontal axis can be achieved via an oblique cut of the bone. The osteotomy with bone to bone contact is fixed with an angle stable plate. INDICATIONS: Symptoms such as anterior knee pain, inwardly pointing knee syndrome, lateral patellar subluxation or dislocation, lateral patellar hypercompression syndrome are a common indication for derivational osteotomy if clinically increased femoral internal rotation and radiologically increased femoral antetorsion is detected...
March 27, 2024: Operative Orthopädie und Traumatologie
https://read.qxmd.com/read/38536082/a-phase-i-trial-of-enzalutamide-plus-selective-glucocorticoid-receptor-modulator-relacorilant-in-patients-with-metastatic-castration-resistant-prostate-cancer
#22
JOURNAL ARTICLE
Kunal B Desai, Anthony V Serritella, Walter M Stadler, Peter H O'Donnell, Randy F Sweis, Russell Z Szmulewitz
PURPOSE: Majority of patients with metastatic prostate cancer who receive androgen deprivation therapy and androgen receptor (AR) signaling inhibitors progress. Activation of the glucocorticoid receptor (GR) is associated with ARSI-resistance. This single-arm phase I trial assessed safety and pharmacokinetic feasibility of combined AR antagonist (enzalutamide) and selective GR modulator (relacorilant) in metastatic castration-resistant prostate cancer (mCRPC) patients. PATIENTS AND METHODS: This was a phase I trial (NCT03674814) of relacorilant and enzalutamide in refractory mCRPC patients enrolled using 6+3 design...
March 27, 2024: Clinical Cancer Research
https://read.qxmd.com/read/38535953/indications-of-endocrine-disruptor-effects-of-jp-5-jet-fuel-using-a-rat-model-reproductive-study-and-an-in-vitro-human-hormone-receptor-assay
#23
JOURNAL ARTICLE
William R Howard, Joyce G Rohan, Kimberly S B Yeager, Chester P Gut, Kathleen A Frondorf, Shawn M McInturf, Nathan M Gargas, Karen L Mumy
Recent events concerning jet fuel contamination of drinking water have shown that we need a better understanding of the effects of ingested jet fuel. To this end, a reproductive study with ingested jet fuel in rats was undertaken with relatively high concentrations of Jet Propellant (JP)-5 along with a human estrogen receptor activation in vitro assay using JP-5, JP-8, and an alternative jet fuel derived from the camelina plant referred to as HydroRenewable Jet (HRJ) fuel, to help evaluate potential effects of ingested jet fuel...
March 16, 2024: Toxics
https://read.qxmd.com/read/38535235/systemic-candida-infection-and-pulmonary-aspergillosis-in-an-alpaca-vicugna-pacos-a-case-report
#24
Andrea Grassi, Claudia Cafarchia, Nicola Decaro, Wafa Rhimi, Vittoriana De Laurentiis, Giulia D'Annunzio, Andrea Luppi, Paola Prati
This study reports a peculiar case of systemic candidiasis infection associated with pulmonary aspergillosis in an apparently immunocompetent alpaca. A captive 7-year-old female alpaca exhibited respiratory symptoms, underwent treatment with benzylpenicillin and dexamethasone, and succumbed to the infection 40 days later. During the post-mortem examination, subcutaneous emphysema, widespread pneumonia with multiple suppurative foci, scattered necro-suppurative lesions throughout the renal and hepatic parenchyma were evident...
March 20, 2024: Journal of Fungi (Basel, Switzerland)
https://read.qxmd.com/read/38534965/safety-and-efficacy-of-convalescent-plasma-combined-with-other-pharmaceutical-agents-for-treatment-of-covid-19-in-hospitalized-patients-a-systematic-review-and-meta-analysis
#25
REVIEW
Massimo Franchini, Daniele Focosi, Mario Cruciani, Michael J Joyner, Liise-Anne Pirofski, Jonathon W Senefeld, Shmuel Shoham, David J Sullivan, Arturo Casadevall
Plasma collected from people recovered from COVID-19 (COVID-19 convalescent plasma, CCP) was the first antibody-based therapy employed to fight the pandemic. CCP was, however, often employed in combination with other drugs, such as the antiviral remdesivir and glucocorticoids. The possible effect of such interaction has never been investigated systematically. To assess the safety and efficacy of CCP combined with other agents for treatment of patients hospitalized for COVID-19, a systematic literature search using appropriate Medical Subject Heading (MeSH) terms was performed through PubMed, EMBASE, Cochrane central, medRxiv and bioRxiv...
February 21, 2024: Diseases (Basel)
https://read.qxmd.com/read/38533793/implementation-of-a-minimally-invasive-cell-culture-system-to-measure-the-regulation-of-inflammation-in-a-school-based-sample-of-adolescents
#26
JOURNAL ARTICLE
Thomas W McDade, Matteo Giletta, Aaron A Miller, Keegan C Krause, Nathalie Michels
Dysregulated inflammation underlies many human diseases, and measures of responsiveness to activation, and sensitivity to inhibition, provide important information beyond baseline assessments of chronic inflammation. This study implements a simplified cell culture protocol in a school-based setting, using finger stick capillary blood collected from 333 adolescents (age 11.4-15.6 years) incubated with lipopolysaccharide (LPS). Median cytokine responses for IL6, IL1β, and TNFα were 61.9, 26...
March 27, 2024: American Journal of Human Biology: the Official Journal of the Human Biology Council
https://read.qxmd.com/read/38533639/cardiac-gr-mediates-the-diurnal-rhythm-in-ventricular-arrhythmia-susceptibility
#27
JOURNAL ARTICLE
Roman Tikhomirov, Robert H Oakley, Cali Anderson, Yirong Xiang, Sami Al Othman, Matthew Smith, Sana Yaar, Eleonora Torre, Jianying Li, Leslie R Wilson, David R Goulding, Ian Donaldson, Erika Harno, Luca Soattin, Holly A Shiels, Gwilym M Morris, Henggui Zhang, Mark R Boyett, John A Cidlowski, Pietro Mesirca, Matteo E Mangoni, Alicia D'Souza
RATIONALE: Ventricular arrhythmias (VAs) demonstrate a prominent day-night rhythm, commonly presenting in the early morning. Transcriptional rhythms in cardiac ion channels accompany this phenomenon, but their role in the morning vulnerability to VAs and the underlying mechanisms are not understood. OBJECTIVE: The objectives are to investigate the recruitment of transcription factors to time-of-day differentially accessible chromatin that underpins day-night ion channel rhythms and to assess the significance of this for the heart's day-night rhythm in VA susceptibility...
March 27, 2024: Circulation Research
https://read.qxmd.com/read/38533325/eosinophilic-granulomatosis-with-polyangiitis-presenting-with-purpura-mononeuritis-multiplex-and-cerebral-infarction
#28
Aswinishree Bagavandoss, Jency Kurian, Samson O Oyibo, Olugbenro O Akintade
We present a case of a 52-year-old woman who had transient speech impediment and progressive numbness, weakness, and a purpuric rash affecting her limbs, with severe joint pains. Because she had a chest infection two weeks prior, her clinical presentation gave rise to a suspicion of post-infective vasculitis or post-infective polyneuritis. Further investigation proved this to be eosinophilic granulomatosis with polyangiitis (EGPA) presenting with purpura, mononeuritis multiplex, and cerebral infarction. Treatment with glucocorticoids and cyclophosphamide led to rapid remission...
March 2024: Curēus
https://read.qxmd.com/read/38533264/korean-red-ginseng-extract-prevents-bone-loss-in-an-oral-model-of-glucocorticoid-induced-osteoporosis-in-mice
#29
JOURNAL ARTICLE
Nicholas J Chargo, Ho Jun Kang, Subhashari Das, Yining Jin, Cheryl Rockwell, Jae Youl Cho, Laura R McCabe, Narayanan Parameswaran
The gut microbiota and barrier function play important roles in bone health. We previously demonstrated that chronic glucocorticoid (GC)-induced bone loss in mice is associated with significant shifts in gut microbiota composition and impaired gut barrier function. Korean Red Ginseng (KRG, Panax Ginseng Meyer, Araliaceae) extract has been shown to prevent glucocorticoid-induced osteoporosis (GIO) in a subcutaneous pellet model in mice, but its effect on gut microbiota and barrier function in this context is not known...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38532870/doping-control-in-male-soccer-players-in-brazil-10-years-of-follow-up
#30
JOURNAL ARTICLE
Herman Fabian Moscovici, Paulo Henrique Schmidt Lara, Fernando Antonio Gaya Solera, Moisés Cohen, Jorge Roberto Pagura, Gustavo Gonçalves Arliani
OBJECTIVE: To understand the Adverse Analytical Finding (AAF) that have occurred in Brazilian soccer in a recent 10-year period, comparing them to international data, to know the Brazilian profile. METHODS: A review of the AAR in the Doping Control Commission database of the Brazilian Football Association from 2008 to 2017. The AAR in professional male soccer players between 2008 and 2017 were considered. RESULTS: The sample selected in this research was composed of 40,092 doping tests, with 113 AAR, identified in 18 different competitions (0...
2024: Acta Ortopedica Brasileira
https://read.qxmd.com/read/38532282/glucocorticoid-induced-hyperglycemia-a-neglected-problem
#31
JOURNAL ARTICLE
Jung-Hwan Cho, Sunghwan Suh
Glucocorticoids provide a potent therapeutic response and are widely used to treat a variety of diseases, including coronavirus disease 2019 (COVID-19) infection. However, the issue of glucocorticoid-induced hyperglycemia (GIH), which is observed in over one-third of patients treated with glucocorticoids, is often neglected. To improve the clinical course and prognosis of diseases that necessitate glucocorticoid therapy, proper management of GIH is essential. The key pathophysiology of GIH includes systemic insulin resistance, which exacerbates hepatic steatosis and visceral obesity, as well as proteolysis and lipolysis of muscle and adipose tissue, coupled with β-cell dysfunction...
March 27, 2024: Endocrinology and Metabolism
https://read.qxmd.com/read/38532238/pharmacological-basis-of-differences-in-dose-response-dose-equivalence-and-duration-of-action-of-inhaled-corticosteroids
#32
JOURNAL ARTICLE
Peter T Daley-Yates, Bhumika Aggarwal, Maximilian Plank
INTRODUCTION: Asthma treatment guidelines classify inhaled corticosteroid (ICS) regimens as low, medium, or high dose. However, efficacy and safety are not independently assessed accordingly. Moreover, differences in ICS duration of action are not considered when a dose regimen is selected. We investigated the efficacy and safety implications of these limitations for available ICS molecules. METHODS: Published pharmacodynamic and pharmacokinetic parameters were used, alongside physiological and pharmacological principles, to estimate the efficacy and safety of available ICS molecules...
March 27, 2024: Advances in Therapy
https://read.qxmd.com/read/38532189/encephalitis-like-episodes-with-cortical-edema-and-enhancement-in-patients-with-neuronal-intranuclear-inclusion-disease
#33
JOURNAL ARTICLE
Yu Shen, Kaiyan Jiang, Hanlin Liang, Ying Xiong, Ziwei Song, Bo Wang, Min Zhu, Yusen Qiu, Dandan Tan, Chengsi Wu, Jianwen Deng, Zhaoxia Wang, Daojun Hong
OBJECTIVES: Neuronal intranuclear inclusion disease (NIID) exhibited significant clinical heterogeneities. However, the clinical features, radiographic changes, and prognosis of patients with encephalitis-like NIID have yet to be systematically elucidated. METHODS: Clinical data including medical history, physical examination, and laboratory examinations were collected and analyzed. Skin and sural nerve biopsies were conducted on the patient. Repeat-primed PCR (RP-PCR) and fluorescence amplicon length PCR (AL-PCR) were used to detect the expansion of CGG repeat...
March 26, 2024: Neurological Sciences
https://read.qxmd.com/read/38531388/a-case-of-generalized-eosinophilic-pustular-folliculitis-treatment-with-jak-inhibitor
#34
JOURNAL ARTICLE
Chunzhi Zheng, Yueqian Yu, Guizhi Zhou, Hong Liu
AIM: This case study aims to report the efficacy and safety of a Janus kinase (JAK) inhibitor in the treatment of generalized eosinophilic pustular folliculitis (EPF). METHODS: We present a case of a 16-year-old Chinese patient who had been suffering from EPF for two years and had shown no response to both topical and systemic glucocorticoids. The patient was subsequently treated with oral tofacitinib at a dosage of 5mg daily. RESULTS: Significant remission of eruption and pruritus was observed in the patient upon treatment with tofacitinib...
December 2024: Journal of Dermatological Treatment
https://read.qxmd.com/read/38531074/opportunities-and-challenges-of-lupus-care-in-latin-america-the-middle-east-and-asia-pacific-a-call-to-action
#35
JOURNAL ARTICLE
Eduardo Mysler, Odirlei Andre Monticielo, Ibrahim Abdulrazaq Al-Homood, Chak Sing Lau, Heselynn Hussein, Yi-Hsing Chen
Lupus remains a disease with a low prioritisation in the national agendas of many countries in Latin America, the Middle East, and Asia-Pacific, where there is a dearth of rheumatologists and limited access to new or even standard lupus treatments. There is thus an important need for education, advocacy, and outreach to prioritise lupus in these regions to ensure that patients receive the care they need. This article reviews some of the specific challenges facing the care and management of people with lupus in these regions and suggests strategies for improving patient outcomes...
January 20, 2024: Modern Rheumatology
https://read.qxmd.com/read/38530453/multisystem-inflammatory-syndrome-in-children-an-umbrella-review
#36
REVIEW
Naohiro Shioji, Makoto Sumie, Marina Englesakis, Elaine Gilfoyle, Jason T Maynes, Kazuyoshi Aoyama
We conducted an Umbrella review of eligible studies to evaluate what patient features have been investigated in the multisystem inflammatory syndrome in children (MIS-C) population, in order to guide future investigations. We comprehensively searched MEDLINE, EMBASE, and Cochrane Database of Systematic Reviews from December 1, 2019 to the May 6, 2022. The time period was limited to cover the coronavirus disease-2019 (COVID-19) pandemic period. The protocol was registered in the PROSPERO registry (CRD42022340228)...
March 26, 2024: Journal of Anesthesia
https://read.qxmd.com/read/38530080/sintilimab-induced-severe-erosive-hemorrhagic-gastritis-and-pyloric-obstruction-a-case-report-and-literature-review
#37
JOURNAL ARTICLE
Wenfang Xiong, Zhenzhen Yang, Youxiang Chen
Immune checkpoint inhibitors could restore immune surveillance to attack tumor through targeting CTLA-4, PD-1 or PD-L1, and have achieved huge success. However, immune-related adverse events (irAEs) have been attracting attention as their application is expanding. Gastritis is relatively rare as a subtype of irAEs, particularly severe gastritis. Guidelines on its clinical management still remain undefined due to limited data. Sintilimab is a PD-1 inhibitor approved in China. Here we offer a case of sintilimab-induced severe erosive hemorrhagic gastritis and pyloric obstruction...
March 26, 2024: Immunotherapy
https://read.qxmd.com/read/38529935/use-of-fracture-risk-assessment-tool-in-clinical-practice-and-fracture-risk-assessment-tool-future-directions
#38
REVIEW
Rahfa Zerikly, Emily Wood Demetriou
Fracture Risk Assessment Tool is a free, online fracture risk calculator which can be used to predict 10-year fracture risk for women and men over age 50 years. It incorporates seven clinical risk factors and bone density to give a 10-year risk of major osteoporotic fracture and hip fracture. This dynamic tool can be used with patients at the bedside to help guide treatment decisions. There are some limitations to Fracture Risk Assessment Tool, with the most central limitation being the fact that inputs are binary...
2024: Women's Health
https://read.qxmd.com/read/38529115/recent-advances-in-the-therapeutic-management-of-calcium-pyrophosphate-deposition-disease
#39
REVIEW
Paraskevi V Voulgari, Aliki I Venetsanopoulou, Alexandros A Drosos
Calcium pyrophosphate deposition (CPPD) disease is a form of crystal-induced arthropathy that arises from the accumulation of calcium pyrophosphate crystals within joints and soft tissues. This process leads to inflammation and damage to the affected joints. It can present asymptomatically or as acute or chronic inflammatory arthritis. Risk factors and comorbidities, including prior joint injury, osteoarthritis, hereditary or familial predisposition, and metabolic diseases, should be evaluated in CPPD cases...
2024: Frontiers in Medicine
https://read.qxmd.com/read/38529007/context-is-key-glucocorticoid-receptor-and-corticosteroid-therapeutics-in-outcomes-after-traumatic-brain-injury
#40
REVIEW
Morgan A Taylor, Olga N Kokiko-Cochran
Traumatic brain injury (TBI) is a global health burden, and survivors suffer functional and psychiatric consequences that can persist long after injury. TBI induces a physiological stress response by activating the hypothalamic-pituitary-adrenal (HPA) axis, but the effects of injury on the stress response become more complex in the long term. Clinical and experimental evidence suggests long lasting dysfunction of the stress response after TBI. Additionally, pre- and post-injury stress both have negative impacts on outcome following TBI...
2024: Frontiers in Cellular Neuroscience
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