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Gelatine matrix thrombin

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https://www.readbyqxmd.com/read/28847147/control-of-major-pulmonary-artery-bleeding-with-a-gelatin-matrix-thrombin-solution-a-retrospective-analysis
#1
Giuseppe Cardillo, Francesco Carleo, Marco DI Martino, Bernardo Ciamberlano, Pasquale Ialongo, Giacomo Cusumano, Maria Denitza Tinti, Alberto Ricci, Stefano Cafarotti
BACKGROUND: Intraoperative pulmonary artery (PA) bleeding is common during thoracic surgery. We investigated the efficacy of the gelatin matrix-thrombin solution FloSeal (Baxter International, Deerfield, IL, USA) for control of major PA bleeding. METHODS: Retrospective data were collected on all intraoperative PA injuries during open or minimally invasive lobectomy or pneumonectomy between January 2000 and January 2014. Patients received either 4/0 prolene sutures (Standard) or the gelatin matrix-thrombin solution, plus sutures as needed (Matrix), with at least 6-month follow-up...
August 28, 2017: Journal of Cardiovascular Surgery
https://www.readbyqxmd.com/read/28439721/incidence-of-thromboembolic-events-after-use-of-gelatin-thrombin-based-hemostatic-matrix-during-intracranial-tumor-surgery
#2
Roberto Gazzeri, Marcelo Galarza, Carlo Conti, Costanzo De Bonis
Association between the use of hemostatic agents made from collagen/gelatin mixed with thrombin and thromboembolic events in patients undergoing tumor resection has been suggested. This study evaluates the relationship between flowable hemostatic matrix and deep vein thrombosis in a large cohort of patients treated for brain tumor removal. The authors conducted a retrospective, multicenter, clinical review of all craniotomies for tumor removal performed between 2013 and 2014. Patients were classified in three groups: group I (flowable gelatin hemostatic matrix with thrombin), group II (gelatin hemostatic without thrombin), and group III (classical hemostatic)...
April 24, 2017: Neurosurgical Review
https://www.readbyqxmd.com/read/28382800/prevention-of-lymphocele-by-using-gelatin-thrombin-matrix-as-a-tissue-sealant-after-pelvic-lymphadenectomy-in-patients-with-gynecologic-cancers-a-prospective-randomized-controlled-study
#3
RANDOMIZED CONTROLLED TRIAL
Yun Hwan Kim, Hyun Joo Shin, Woong Ju, Seung Cheol Kim
OBJECTIVE: This prospective randomized controlled pilot study aimed to find whether gelatin-thrombin matrix used as a tissue sealant (FloSeal) can prevent the occurrence of pelvic lymphocele in patients with gynecologic cancer who has undergone pelvic lymphadenectomy. METHODS: Each patient, who undergo a laparotomic pelvic lymph node dissection on both sides, was randomly assigned for FloSeal application on 1 side of the pelvis. The other side of the pelvis without any product application being the control side...
May 2017: Journal of Gynecologic Oncology
https://www.readbyqxmd.com/read/28358708/improvement-of-perioperative-outcomes-in-major-gynecological-and-gynecologic-oncological-surgery-with-hemostatic-gelatin-thrombin-matrix
#4
Rafał Watrowski, Christoph Jäger, Johannes Forster
AIM: To assess the impact of the use of intraoperative hemostatic gelatin-thrombin matrix (HM) (Floseal®, Baxter Healthcare) on transfusion rates and short-term perioperative outcomes in gynecological surgery. PATIENTS AND METHODS: In this retrospective, single-center study, we evaluated data of 215 patients (83 cases and 132 controls) undergoing extensive gynecological surgery (e.g. oncological procedures) with and without intraoperative HM application. RESULTS: Cases and controls did not differ according to age, preoperative hemoglobin (Hb) concentration, and Hb or C-reactive protein (CRP) levels at discharge...
March 2017: In Vivo
https://www.readbyqxmd.com/read/28246047/is-the-use-of-hemostatic-matrix-floseal-and-alkylene-oxide-copolymer-ostene-safe-in-spinal-laminectomies-peridural-fibrosis-assessment
#5
Oktay Gurcan, Ahmet Gurhan Gurcay, Atilla Kazanci, Evrim Onder, Salim Senturk, Murad Bavbek
OBJECTIVE: Failed Back Syndrome (FBS) is unacceptable relief of pain or recurrence of symptoms in patients after spinal surgery, such as laminectomy. One possible cause of FBS is peridural fibrosis (PF). PF is the overproduction of scar tissue adjacent to the dura mater. Bleeding can cause PF after laminectomy. Ostene is an alkylene oxide copolymer material used to stop bleeding from bony surfaces. Floseal is a gelatin thrombin matrix sealant used to assist fibrin formation and to promote coagulation...
February 25, 2017: Acta Orthopaedica et Traumatologica Turcica
https://www.readbyqxmd.com/read/27456032/gelatin-thrombin-hemostatic-matrix-in-neurosurgical-procedures-hemostasis-effectiveness-and-economic-value-of-clinical-and-surgical-procedure-related-benefits
#6
Felice Esposito, Paolo Cappabianca, Filippo F Angileri, Luigi M Cavallo, Stefano M Priola, Salvatore Crimi, Domenico Solari, Antonino F Germanò, Francesco Tomasello
OBJECTIVES: Gelatin-thrombin hemostatic matrix (FloSeal®) use is associated with shorter surgical times and less blood loss, parameters that are highly valued in neurosurgical procedures. We aimed to assess the effectiveness of gelatin-thrombin in neurosurgical procedures and estimate its economic value. PATIENTS AND METHODS: In a 6-month retrospective evaluation at 2 hospitals, intraoperative and postoperative information were collected from patients undergoing neurosurgical procedures where bleeding was controlled with gelatin-thrombin matrix or according to local bleeding control guidelines (control group)...
July 26, 2016: Journal of Neurosurgical Sciences
https://www.readbyqxmd.com/read/27414284/use-of-a-gelatin-thrombin-hemostatic-matrix-for-secondary-bleeding-after-pediatric-tonsillectomy
#7
Adem Binnetoglu, Berat Demir, Ali Cemal Yumusakhuylu, Tekin Baglam, Murat Sari
Importance: Secondary posttonsillectomy bleeding associated with oozing from multiple sites or overcauterized tonsillar bed deserves special evaluation. Objective: To evaluate the use of an absorbable, flowable gelatin-thrombin hemostatic matrix (GTHM) sealant for secondary bleeding after tonsillectomy. Design, Setting, and Participants: This was a retrospective data analysis, with information gathered from medical records of pediatric patients with secondary posttonsillectomy bleeding treated with the GTHM between 2012 and 2016 at a referral center and a local satellite facility...
October 1, 2016: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/27384096/novel-approach-of-treatment-of-pilonidal-sinus-disease-with-thrombin-gelatin-matrix-as-a-sealant
#8
Hosam G Elbanna, Sameh Hany Emile, Mohamed Youssef, Waleed Thabet, Tito M Abd El-Hamed, Wagih M Ghnnam
BACKGROUND: Sacrococcygeal pilonidal sinus disease is a condition caused by insertion of fallen hair shafts into the skin. Different types of operations have been described for the management of pilonidal sinus, yet none of them have proven to be superior to the others. Recently, sealants like fibrin glue have been successfully used. OBJECTIVE: This study aimed to assess the efficacy of thrombin gelatin matrix as a new sealant for pilonidal sinus treatment. DESIGN: This was a prospective study conducted from March 2013 to March 2015...
August 2016: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/27199534/influence-of-gelatin-thrombin-matrix-tissue-sealant-on-bacterial-colony-formation-and-risk-of-pelvic-infection
#9
Michael J Jarrett, Andres Vázquez-Torres, Daniel N Frank, Bruce D McCollister, Patrick K Henthorn, Diana Ir, Jeanelle Sheeder, Michael S Guy, Hiba Q Anwar, Kian Behbakht
Objective. Gelatin-thrombin matrix (GTM) tissue sealant use was previously identified as an independent predictor of pelvic infection following hysterectomies. We aim to elucidate contributing factors by assessing influence of GTM on bacterial colony formation and characterizing bacteria present at the vaginal cuff. Methods. Escherichia coli was incubated in phosphate-buffered saline (PBS) and pelvic washings with and without GTM to assess influence on colony formation. Pelvic washings of the vaginal cuff were collected from hysterectomies occurring from June through October 2015...
2016: Infectious Diseases in Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27181591/thrombin-enhanced-matrix-metalloproteinase-9-expression-and-migration-of-sk-n-sh-cells-via-par-1-c-src-pyk2-egfr-erk1-2-and-ap-1
#10
Chien-Chung Yang, Li-Der Hsiao, Chuen-Mao Yang, Chih-Chung Lin
Neuroinflammation is a hallmark of neurodegenerative disorders in the central nerve system (CNS). Thrombin has been known as one of the factors in pathological processes including migration, blood-brain barrier breakdown, brain edema formation, neuroinflammation, and neuronal death. Thrombin has been shown to be a regulator of matrix metalloproteinase (MMPs) expression leading to cell migration. Among MMPs, the elevated expression of MMP-9 has been observed in patients with brain diseases, which may contribute to the pathology of neuroinflammatory and neurodegenerative diseases...
July 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/26920966/gelatine-matrix-with-human-thrombin-decreases-blood-loss-in-adolescents-undergoing-posterior-spinal-fusion-for-idiopathic-scoliosis-a-multicentre-randomised-clinical-trial
#11
RANDOMIZED CONTROLLED TRIAL
I Helenius, H Keskinen, J Syvänen, H Lukkarinen, M Mattila, J Välipakka, O Pajulo
AIMS: In a multicentre, randomised study of adolescents undergoing posterior spinal fusion for idiopathic scoliosis, we investigated the effect of adding gelatine matrix with human thrombin to the standard surgical methods of controlling blood loss. PATIENTS AND METHODS: Patients in the intervention group (n = 30) were randomised to receive a minimum of two and a maximum of four units of gelatine matrix with thrombin in addition to conventional surgical methods of achieving haemostasis...
March 2016: Bone & Joint Journal
https://www.readbyqxmd.com/read/26713124/efficacy-of-a-topical-gelatin-thrombin-matrix-sealant-in-reducing-postoperative-drainage-following-anterior-cervical-discectomy-and-fusion
#12
Quan You Li, Osung Lee, Ho Sung Han, Gang-Un Kim, Chee Kean Lee, Sung Shik Kang, Myung Ho Lee, Hyeon Guk Cho, Ho-Joong Kim, Jin S Yeom
STUDY DESIGN: Retrospective fusion level(s)-, age-, and gender-matched analysis. PURPOSE: To determine whether the application of a topical gelatin-thrombin matrix sealant (Floseal) at the end of anterior cervical discectomy and fusion (ACDF) can reduce the amount of postoperative hemorrhage. OVERVIEW OF LITERATURE: The effect of the matrix sealant in decreasing postoperative hemorrhage following ACDF has not been reported. METHODS: Matrix sealant was (n=116, study group) or was not applied (n=58, control group) at the end of ACDF...
December 2015: Asian Spine Journal
https://www.readbyqxmd.com/read/26680379/an-in-vivo-comparison-of-hemostatic-gelatin-matrix-products-in-a-porcine-spleen-biopsy-punch-model
#13
COMPARATIVE STUDY
Richard W Hutchinson, Stephanie Werrlein, Douglas B Johns, Gary Zhang, Jeffrey W Clymer, Richard Kocharian
Flowable gelatin matrix products have established themselves as effective, easy-to-use hemostatic agents useful in a variety of surgical situations. A recently reformulated gelatin matrix, Surgiflo® (Ethicon Inc., Somerville, NJ), can be prepared quickly and provides consistent flow over an 8-hr. period. No in vivo studies have yet been reported comparing hemostasis with the new Surgiflo to other currently marketed flowable gelatin matrix products. This study was conducted to determine whether Surgiflo in actual use has hemostatic qualities different from another commercial gelatin matrix...
November 2015: Surgical Technology International
https://www.readbyqxmd.com/read/26497035/thrombin-matrix-metalloproteinase-9-dependent-sk-n-sh-cell-migration-is-mediated-through-a-plc-pkc-mapks-nf-%C3%AE%C2%BAb-cascade
#14
Chien-Chung Yang, Chih-Chung Lin, Peter Tzu-Yu Chien, Li-Der Hsiao, Chuen-Mao Yang
Thrombin has been known to activate inflammatory genes including matrix metalloproteinases (MMPs). The elevated expression of MMP-9 has been observed in patients with neuroinflammatory diseases and may contribute to the pathology of brain diseases. However, the mechanisms underlying thrombin-induced MMP-9 expression in SK-N-SH cells remain unknown. The effects of thrombin on MMP-9 expression were examined in SK-N-SH cells by gelatin zymography, Western blot, real-time PCR, promoter activity assay, and cell migration assay...
November 2016: Molecular Neurobiology
https://www.readbyqxmd.com/read/26345501/an-in-vivo-comparison-of-hemostatic-gelatin-matrix-products-in-a-porcine-spleen-biopsy-punch-model
#15
Richard W Hutchinson, Stephanie Werrlein, Douglas B Johns, Gary Zhang, Jeffrey W Clymer, Richard Kocharian
Flowable gelatin matrix products have established themselves as effective, easy-to-use hemostatic agents useful in a variety of surgical situations. A recently reformulated gelatin matrix, Surgiflo® (Ethicon Inc., Somerville, NJ), can be prepared quickly and provides consistent flow over an 8-hr. PERIOD: No in vivo studies have yet been reported comparing hemostasis with the new Surgiflo to other currently marketed flowable gelatin matrix products. This study was conducted to determine whether Surgiflo in actual use has hemostatic qualities different from another commercial gelatin matrix...
September 4, 2015: Surgical Technology International
https://www.readbyqxmd.com/read/26337014/control-of-major-pulmonary-artery-bleeding-with-a-gelatin-matrix-thrombin-solution-a-retrospective-analysis
#16
Giuseppe Cardillo, Francesco Carleo, Marco DI Martino, Bernardo Ciamberlano, Pasquale Ialongo, Giacomo Cusumano, Maria Denitza Tinti, Alberto Ricci, Stefano Cafarotti
BACKGROUND: Intraoperative pulmonary artery (PA) bleeding is common during thoracic surgery. We investigated the efficacy of the gelatin matrix-thrombin solution FloSeal (Baxter International, Deerfield, IL, USA) for control of major PA bleeding. METHODS: Retrospective data were collected on all intraoperative PA injuries during open or minimally invasive lobectomy or pneumonectomy between January 2000 and January 2014. Patients received either 4/0 prolene sutures (Standard) or the gelatin matrix-thrombin solution, plus sutures as needed (Matrix), with at least 6-month follow-up...
December 2017: Journal of Cardiovascular Surgery
https://www.readbyqxmd.com/read/26316398/a-novel-use-of-direct-platelet-application-during-surgery-for-clopidogrel-associated-intracerebral-hemorrhage
#17
Brendan D Killory, Kent J Kilbourn, Martin Ollenschleger
BACKGROUND: Dual antiplatelet therapy is associated with increased rates of intracerebral hemorrhage, especially in the context of subarachnoid hemorrhage. We present a case of a spontaneous hemorrhage in a patient treated with a Pipeline stent for a ruptured dissecting vertebrobasilar aneurysm and the novel use of direct application of platelets during surgery to control bleeding. CASE DESCRIPTION: A 54-year-old previously healthy woman presented with an intradural right vertebral artery dissection with a ruptured 6-mm pseudoaneurysm...
December 2015: World Neurosurgery
https://www.readbyqxmd.com/read/26243629/a-gelatin-thrombin-matrix-topical-hemostatic-agent-floseal-in-combination-with-harmonic-scalpel-is-effective-in-patients-undergoing-total-thyroidectomy-a-prospective-multicenter-single-blind-randomized-controlled-trial
#18
RANDOMIZED CONTROLLED TRIAL
Giovanni Docimo, Salvatore Tolone, Giovanni Conzo, Paolo Limongelli, Gianmattia Del Genio, Domenico Parmeggiani, Maurizio De Palma, Gennaro Lupone, Nicola Avenia, Roberta Lucchini, Massimo Monacelli, Gaspare Gulotta, Gregorio Scerrino, Daniela Pasquali, Giuseppe Bellastella, Katherine Esposito, Annamaria De Bellis, Angela Pezzolla, Roberto Ruggiero, Ludovico Docimo
BACKGROUND: Hemostasis during thyroidectomy is essential; however, the safest, most efficient, and most cost-effective way to achieve this is unclear. This randomized, multicenter, single-blind, prospective study evaluated the efficacy and safety of using different hemostatic approaches in patients undergoing total thyroidectomy. METHODS: Patients aged ≥18 to 70 years were randomized to Floseal + a harmonic scalpel (HS), Floseal alone, HS alone, or standard total thyroidectomy...
February 2016: Surgical Innovation
https://www.readbyqxmd.com/read/26037982/use-of-local-pro-coagulant-haemostatic-agents-for-intra-cavity-control-of-haemorrhage-after-trauma
#19
REVIEW
A Navarro, A Brooks
INTRODUCTION: Uncontrolled haemorrhage as a result of trauma remains a significant surgical challenge, accounting for approximately 25-40% of trauma-related mortality. A wide range of local internal haemostatic agents have been developed to help achieve intra-cavity control of bleeding, with choice of agent influenced by the circumstances and nature of the haemorrhage. Trauma patients are frequently coagulopathic, so products that incorporate pro-coagulant technology and thereby act independently of the clotting cascade may be more effective in these settings...
October 2015: European Journal of Trauma and Emergency Surgery: Official Publication of the European Trauma Society
https://www.readbyqxmd.com/read/25943630/bilateral-pulmonary-emboli-associated-with-intraoperative-use-of-thrombin-based-hemostatic-matrix-following-lumbar-spine-interbody-fusion
#20
Zhikui Wei, Benjamin D Elder, C Rory Goodwin, Timothy F Witham
Here we describe a patient with bilateral pulmonary emboli (PE) associated with thrombin-based hemostatic matrix (TBHM) use in the setting of a possible venous injury during transforaminal lumbar interbody fusion in the treatment of degenerative spondylolisthesis at L4-5. TBHM products are gelatin granules mixed with human or bovine thrombin. They have been used in a wide variety of surgical procedures to facilitate local hemostasis though their use is not without complications. This is the first reported patient, to our knowledge, with a TBHM-related PE following spinal fusion...
September 2015: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
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