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https://www.readbyqxmd.com/read/28847147/control-of-major-pulmonary-artery-bleeding-with-a-gelatin-matrix-thrombin-solution-a-retrospective-analysis
#1
Giuseppe Cardillo, Francesco Carleo, Marco DI Martino, Bernardo Ciamberlano, Pasquale Ialongo, Giacomo Cusumano, Maria Denitza Tinti, Alberto Ricci, Stefano Cafarotti
BACKGROUND: Intraoperative pulmonary artery (PA) bleeding is common during thoracic surgery. We investigated the efficacy of the gelatin matrix-thrombin solution FloSeal (Baxter International, Deerfield, IL, USA) for control of major PA bleeding. METHODS: Retrospective data were collected on all intraoperative PA injuries during open or minimally invasive lobectomy or pneumonectomy between January 2000 and January 2014. Patients received either 4/0 prolene sutures (Standard) or the gelatin matrix-thrombin solution, plus sutures as needed (Matrix), with at least 6-month follow-up...
August 28, 2017: Journal of Cardiovascular Surgery
https://www.readbyqxmd.com/read/28755096/analysis-of-the-hemostatic-potential-of-modern-topical-sealants-on-arterial-and-venous-anastomoses-an-experimental-porcine-study
#2
Hamidreza Fonouni, Arash Kashfi, Ali Majlesara, Oliver Stahlheber, Lukas Konstantinidis, Thomas W Kraus, Arianeb Mehrabi, Hani Oweira
One of the widely accepted adjunctive agents in the variety of surgical modalities are sealants. Our study aim was to compare four commonly used modern sealants in a standardized experimental setting to assess their feasibility, and hemostatic efficacy in vascular anastomosis. Forty landrace pigs (weight: 24.7 ± 3.8 kg) were randomized into the control (n = 8) and four sealant groups; TachoSil® (n = 8), Tissucol Duo® (n = 8), Coseal® (n = 8), and FloSeal® (n = 8). After doing a portal vein end-to-end anastomosis as well as stitches of aortic incision, the sealants were applied on anastomotic site...
September 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/28677091/does-topical-hemostatic-agent-floseal-%C3%A2-have-a-long-term-adverse-effect-on-erectile-function-recovery-after-nerve-sparing-robot-assisted-radical-prostatectomy
#3
Eugenio Martorana, Bernardo Rocco, Shaniko Kaleci, Giacomo Maria Pirola, Luigi Bevilacqua, Luca Reggiani Bonetti, Stefano Puliatti, Salvatore Micali, Giampaolo Bianchi
OBJECTIVES: To investigate the long-term effects of Floseal(®) on erectile function recovery (EFR) after nerve-sparing robot-assisted radical prostatectomy (RALP). METHODS: We prospectively collected results of the self-administered International Index Erectile Function Questionnaire 1-5 and 15 (IIEF 1-5 and 15) of 532 consecutive patients who underwent RALP for prostate cancer in our institution between October 2007 and December 2015. Patients were divided into two groups according to Floseal(®) application after prostatectomy...
July 4, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/28644516/hemostatic-efficiency-of-modern-topical-sealants-comparative-evaluation-after-liver-resection-and-splenic-laceration-in-a-swine-model
#4
Hamidreza Fonouni, Arash Kashfi, Ali Majlesara, Oliver Stahlheber, Lukas Konstantinidis, Negin Gharabaghi, Thomas W Kraus, Arianeb Mehrabi, Hani Oweira
Parenchymal transection during hepatobiliary surgery can disrupt small vasculature or bile ducts, which could be managed difficultly. Sealants are helpful tools to achieve better hemostasis. The aim of this study is to analyze the hemostatic efficiency of four modern sealants in a porcine model. In this study, 40 landrace pigs were assigned equally to the control (without sealant) and four sealant groups. Standardized liver resection and splenic lesions were performed and left without using sealant (control) or treated with one of the following sealants: TachoSil(®) , Tissucol Duo(®) , Coseal(®) , and FloSeal(®) ...
June 23, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/28382800/prevention-of-lymphocele-by-using-gelatin-thrombin-matrix-as-a-tissue-sealant-after-pelvic-lymphadenectomy-in-patients-with-gynecologic-cancers-a-prospective-randomized-controlled-study
#5
RANDOMIZED CONTROLLED TRIAL
Yun Hwan Kim, Hyun Joo Shin, Woong Ju, Seung Cheol Kim
OBJECTIVE: This prospective randomized controlled pilot study aimed to find whether gelatin-thrombin matrix used as a tissue sealant (FloSeal) can prevent the occurrence of pelvic lymphocele in patients with gynecologic cancer who has undergone pelvic lymphadenectomy. METHODS: Each patient, who undergo a laparotomic pelvic lymph node dissection on both sides, was randomly assigned for FloSeal application on 1 side of the pelvis. The other side of the pelvis without any product application being the control side...
May 2017: Journal of Gynecologic Oncology
https://www.readbyqxmd.com/read/28358708/improvement-of-perioperative-outcomes-in-major-gynecological-and-gynecologic-oncological-surgery-with-hemostatic-gelatin-thrombin-matrix
#6
Rafał Watrowski, Christoph Jäger, Johannes Forster
AIM: To assess the impact of the use of intraoperative hemostatic gelatin-thrombin matrix (HM) (Floseal®, Baxter Healthcare) on transfusion rates and short-term perioperative outcomes in gynecological surgery. PATIENTS AND METHODS: In this retrospective, single-center study, we evaluated data of 215 patients (83 cases and 132 controls) undergoing extensive gynecological surgery (e.g. oncological procedures) with and without intraoperative HM application. RESULTS: Cases and controls did not differ according to age, preoperative hemoglobin (Hb) concentration, and Hb or C-reactive protein (CRP) levels at discharge...
March 2017: In Vivo
https://www.readbyqxmd.com/read/28356138/can-floseal%C3%A2-be-applied-safely-during-otologic-surgery-assessment-of-ototoxicity-in-a-chinchilla-animal-model
#7
Carol Nhan, Aren Bezdjian, Abdullah Alarfaj, Sam J Daniel
BACKGROUND: In otologic surgery good visualization is paramount, and patients with bleeding diatheses or who need to be anti-coagulated can present a significant challenge. Here, we determine whether Floseal™, a hemostatic matrix, is ototoxic in a validated animal model. METHODS: Nine chinchillas housed in the animal care facilities of the Montreal Children's Hospital Research Institute were used for the study. After a myringotomy incision was made in each tympanic membrane, baseline auditory brainstem response measurements were performed at 8, 20, and 25 kHz...
March 29, 2017: Journal of Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/28343893/local-hemostatic-matrix-for-endoscope-assisted-removal-of-intracerebral-hemorrhage-is-safe-and-effective
#8
Hui-Tzung Luh, Abel Po-Hao Huang, Shih-Hung Yang, Chien-Ming Chen, Der-Yang Cho, Chun-Chung Chen, Lu-Ting Kuo, Chieh-Hsun Li, Kuo-Chuan Wang, Wei-Lung Tseng, Ming-Tai Hsing, Bing-Shiang Yang, Dar-Ming Lai, Jui-Chang Tsai
BACKGROUND/PURPOSE: Minimally invasive endoscope-assisted (MIE) evacuation of spontaneous intracerebral hemorrhage (ICH) is simple and effective, but the limited working space may hinder meticulous hemostasis and might lead to rebleeding. Management of intraoperative hemorrhage is therefore a critical issue of this study. This study presents experience in the treatment of patients with various types of ICH by MIE evacuation followed by direct local injection of FloSeal Hemostatic Matrix (Baxter Healthcare Corp, Fremont, CA, USA) for hemostasis...
March 23, 2017: Journal of the Formosan Medical Association, Taiwan Yi Zhi
https://www.readbyqxmd.com/read/28287015/cost-consequence-analysis-of-two-different-active-flowable-hemostatic-matrices-in-spine-surgery-patients
#9
D Makhija, M Rock, S Ikeme, E Kuntze, J D Epstein, G Nicholson, J S Price, V Patel
OBJECTIVES: A recently published retrospective analysis comparing two different active flowable hemostatic matrices (FLOSEAL and SURGIFLO Kit with Thrombin) showed significantly increased resource use and complications (surgery time, risk of blood product transfusion, and amount of matrix used) with SURGIFLO use compared to FLOSEAL in major spine surgery, and also significantly increased surgical time with SURGIFLO use in severe spine surgery. This analysis was developed as a follow-up to this prior analysis, to evaluate the cost-consequence of using FLOSEAL vs SURGIFLO in major and severe spine surgery...
June 2017: Journal of Medical Economics
https://www.readbyqxmd.com/read/28246047/is-the-use-of-hemostatic-matrix-floseal-and-alkylene-oxide-copolymer-ostene-safe-in-spinal-laminectomies-peridural-fibrosis-assessment
#10
Oktay Gurcan, Ahmet Gurhan Gurcay, Atilla Kazanci, Evrim Onder, Salim Senturk, Murad Bavbek
OBJECTIVE: Failed Back Syndrome (FBS) is unacceptable relief of pain or recurrence of symptoms in patients after spinal surgery, such as laminectomy. One possible cause of FBS is peridural fibrosis (PF). PF is the overproduction of scar tissue adjacent to the dura mater. Bleeding can cause PF after laminectomy. Ostene is an alkylene oxide copolymer material used to stop bleeding from bony surfaces. Floseal is a gelatin thrombin matrix sealant used to assist fibrin formation and to promote coagulation...
February 25, 2017: Acta Orthopaedica et Traumatologica Turcica
https://www.readbyqxmd.com/read/28097913/cost-consequence-analysis-of-different-active-flowable-hemostatic-matrices-in-cardiac-surgical-procedures
#11
D Makhija, M Rock, Y Xiong, J D Epstein, M R Arnold, O M Lattouf, D Calcaterra
BACKGROUND: A recent retrospective comparative effectiveness study found that use of the FLOSEAL Hemostatic Matrix in cardiac surgery was associated with significantly lower risks of complications, blood transfusions, surgical revisions, and shorter length of surgery than use of SURGIFLO Hemostatic Matrix. These outcome improvements in cardiac surgery procedures may translate to economic savings for hospitals and payers. OBJECTIVE: The objective of this study was to estimate the cost-consequence of two flowable hemostatic matrices (FLOSEAL or SURGIFLO) in cardiac surgeries for US hospitals...
February 3, 2017: Journal of Medical Economics
https://www.readbyqxmd.com/read/27861945/rapid-hemostasis-in-a-sheep-model-using-particles-that-propel-thrombin-and-tranexamic-acid
#12
James R Baylis, Andres Finkelstein-Kulka, Luis Macias-Valle, Jamil Manji, Michael Lee, Elina Levchenko, Christopher Okpaleke, Salahuddin Al-Salihi, Amin Javer, Christian J Kastrup
OBJECTIVES/HYPOTHESIS: Bleeding during endoscopic sinus surgery and open surgeries can easily obstruct the surgeons' field of view and increase morbidity and risk of intraoperative complications. Intraoperative bleeding could potentially be addressed by a hemostatic agent that safely disperses itself through the escaping blood. We tested the safety and efficacy of a self-propelling formulation of thrombin and tranexamic acid (SPTT) in stopping bleeding in a paranasal sinus injury and in an open surgical carotid injury sheep model...
April 2017: Laryngoscope
https://www.readbyqxmd.com/read/27713677/intraoperative-anaphylactic-reaction-is-it-the-floseal
#13
Brianne Bordes, David Martin, Brian Schloss, Allan Beebe, Walter Samora, Jan Klamar, David Stukus, Joseph D Tobias
When hemodynamic or respiratory instability occurs intraoperatively, the inciting event must be determined so that a therapeutic plan can be provided to ensure patient safety. Although generally uncommon, one cause of cardiorespiratory instability is anaphylactic reactions. During anesthetic care, these most commonly involve neuromuscular blocking agents, antibiotics, or latex. Floseal is a topical hemostatic agent that is frequently used during orthopedic surgical procedures to augment local coagulation function and limit intraoperative blood loss...
July 2016: Journal of Pediatric Pharmacology and Therapeutics: JPPT: the Official Journal of PPAG
https://www.readbyqxmd.com/read/27600650/hemostatic-matrix-floseal-as-treatment-for-urethral-crush-injury-after-failure-of-traditional-hemostatic-technique
#14
Barrett R Park, Damon R Kuehl
We report a case of traumatic arterial hemorrhage from the posterior urethral artery, refractory to traditional hemostatic technique, and successfully managed with intraurethral thrombin hemostatic matrix (FloSeal [Baxter Healthcare Corporation, Deerfield, Illinois, US]). We believe that this demonstrates a safe, effective therapy for urethral hemorrhage that may be accomplished by Emergency Physicians and may preclude the need for more invasive hemorrhage control strategies.
December 2016: Annals of Emergency Medicine
https://www.readbyqxmd.com/read/27535119/cytologic-findings-following-intraoperative-use-of-floseal-r-hemostatic-matrix-a-potential-diagnostic-pitfall-in-fluid-aspiration-cytology
#15
Julieta E Barroeta, Elliott Lhospital, Eugene Smith, Emily M Ko
We report the case of a 62-year-old woman who underwent laparoscopic hysterectomy, bilateral salpingo-oophorectomy, and lymph node dissection for endometrial endometrioid carcinoma FIGO grade 1. Cytologic examination of the pelvic washing specimen showed an acellular matrix with frayed edges and cracking artifact. Upon investigation, it became apparent that this could represent hemostatic matrix Floseal(R) that had been used intraoperatively at the lymphadenectomy site. Laboratory replication of the cytologic findings with a Floseal(R) sample confirmed it...
December 2016: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/27490981/the-use-of-floseal-haemostatic-sealant-in-the-management-of-epistaxis-a-prospective-clinical-study-and-literature-review
#16
O C Wakelam, P A Dimitriadis, J Stephens
INTRODUCTION It is standard practice in the UK that if conservative measures or chemical cautery fail to control epistaxis, patients receive nasal packing which is often uncomfortable, requires admission and has well documented associated morbidity. Our study aims to evaluate the use of FloSeal haemostatic sealant in managing patients with epistaxis. MATERIALS AND METHODS Patients were identified from those referred with active epistaxis. A successful outcome was defined as complete haemostasis with FloSeal alone, with no further significant bleeding requiring admission or further interventions in the subsequent 7 days...
January 2017: Annals of the Royal College of Surgeons of England
https://www.readbyqxmd.com/read/27490907/use-of-thrombin-based-haemostatic-matrix-in-head-and-neck-reconstructions-a-potential-risk-factor-for-pulmonary-embolism
#17
Brian Y T Yue, Richard Zinn, Rachael Roberts, Jeremy Wilson
BACKGROUND: Haemostatic agents including thrombin-based haemostatic matrix are widely used in patients undergoing cardiac, vascular and spinal surgery. These agents promote local haemostasis through activation of the clotting cascade. To our knowledge, this case series is the first report of pulmonary embolization associated with FloSeal following head and neck oncology resection and free flap reconstruction. METHODS: We present five patients who were diagnosed with symptomatic pulmonary embolism after oncologic head and neck free flap reconstructions in 2014 and 2015...
August 3, 2016: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/27456032/gelatin-thrombin-hemostatic-matrix-in-neurosurgical-procedures-hemostasis-effectiveness-and-economic-value-of-clinical-and-surgical-procedure-related-benefits
#18
Felice Esposito, Paolo Cappabianca, Filippo F Angileri, Luigi M Cavallo, Stefano M Priola, Salvatore Crimi, Domenico Solari, Antonino F Germanò, Francesco Tomasello
OBJECTIVES: Gelatin-thrombin hemostatic matrix (FloSeal®) use is associated with shorter surgical times and less blood loss, parameters that are highly valued in neurosurgical procedures. We aimed to assess the effectiveness of gelatin-thrombin in neurosurgical procedures and estimate its economic value. PATIENTS AND METHODS: In a 6-month retrospective evaluation at 2 hospitals, intraoperative and postoperative information were collected from patients undergoing neurosurgical procedures where bleeding was controlled with gelatin-thrombin matrix or according to local bleeding control guidelines (control group)...
July 26, 2016: Journal of Neurosurgical Sciences
https://www.readbyqxmd.com/read/26987637/a-cost-effective-delivery-system-for-floseal-during-endoscopic-and-microscopic-brain-surgery
#19
Yves Brand, Vairavan Narayanan, Narayanan Prepageran, Vicknes Waran
OBJECTIVE: To share our experience with a new delivery system for the flowable hemostatic matrix, FloSeal, in endoscopic and microscopic skull base surgery. METHODS: We prospectively analyzed the use of FloSeal with a hemostatic delivery system in transnasal endoscopic and microscopic skull base procedures performed at the authors' institution from January 1, 2015, to June 30, 2015. In all cases the number of aliquots was noted for the entire operation, and the total number of FloSeal ampules of 5 mL was also recorded...
June 2016: World Neurosurgery
https://www.readbyqxmd.com/read/26920703/evaluating-the-use-of-floseal-haemostatic-matrix-in-the-treatment-of-epistaxis-a-prospective-control-matched-longitudinal-study
#20
Andrew S Lau, Navdeep S Upile, Lepa Lazarova, Andrew C Swift
Epistaxis is a common cause of emergency admissions in ENT. The use of Floseal haemostatic matrix in the treatment of epistaxis has been investigated in a number of studies in North America. We aimed to report a UK-based experience in the context of the current UK management paradigm. The study was designed as a prospective, unrandomised, control-matched longitudinal study. Cases were matched to controls in order to reduce the risk of bias. The overall treatment success rate for Floseal was 75 %, similar to the rates reported by studies based in North America...
September 2016: European Archives of Oto-rhino-laryngology
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