Dilan Canyurt, Lokman Hekim Tanriverdi, Onural Ozhan, Mehmet Cansel, Hakan Parlakpinar, Nigar Vardi, Yilmaz Cigremis, Azibe Yildiz, Yucel Karaca, Seyma Yasar, Ahmet Acet
Modafinil is used for the treatment of various sleep disorders; however, its usage among healthy individuals is also increasing. There are a limited number of cardiovascular side effects, including ischemic T-wave changes, dyspnea, hypertension, and tachycardia in the literature. Our research aimed to investigate the dose-dependent subacute cardiovascular effects of modafinil in rats. Thirty-two rats were randomly and equally assigned to a control group (vehicle-treated for 14 days), a subacute low-dose group (SALD, 10 mg/kg for 14 days), a subacute moderate-dose group (SAMD, 100 mg/kg for 14 days), and a subacute high-dose group (SHD, 600 mg/kg for 14 days)...
May 2022: Drug and Chemical Toxicology