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atrioventricular blockage

Fernando Bonet, Ángel Dueñas, Carmen López-Sánchez, Virginio García-Martínez, Amelia E Aránega, Diego Franco
BACKGROUND: Valve development is a multistep process involving the activation of the cardiac endothelium, epithelial-mesenchymal transition (EMT) and the progressive alignment and differentiation of distinct mesenchymal cell types. Several pathways such as Notch/delta, Tgf-beta and/or Vegf signaling have been implicated in crucial steps of valvulogenesis. We have previously demonstrated discrete changes in microRNAs expression during cardiogenesis, which are predicted to target Bmp- and Tgf-beta signaling...
October 2015: Developmental Dynamics: An Official Publication of the American Association of Anatomists
Mehmet Aksoy, Ilker Ince, Ali Ahiskalioglu, Nazim Dogan, Abdurrahim Colak, Serdar Sevimli
OBJECTIVE: The objective of this study is to evaluate the first applications and short term outcomes of transcatheter aortic valve implantation (TAVI) in our clinic, which is a new technology for the patients with high risk for surgical aortic valve replacement (SAVR). MATERIALS AND METHODS: Between January 2010 and December 2012, twenty five patients (16 males, 9 females; mean age 74.04±8.86 years) diagnosed with severe aortic stenosis, who were at high risk for surgery (EuroSCORE II: 5...
June 2015: Eurasian Journal of Medicine
Pilar Brito-Zerón, Peter M Izmirly, Manuel Ramos-Casals, Jill P Buyon, Munther A Khamashta
Autoimmune congenital heart block (CHB) is an immune-mediated acquired disease that is associated with the placental transference of maternal antibodies specific for Ro and La autoantigens. The disease develops in a fetal heart without anatomical abnormalities that could otherwise explain the block, and which is usually diagnosed in utero, but also at birth or within the neonatal period. Autoantibody-mediated damage of fetal conduction tissues causes inflammation and fibrosis and leads to blockage of signal conduction at the atrioventricular (AV) node...
May 2015: Nature Reviews. Rheumatology
Lin Chen, Yingbin Xiao, Ruiyan Ma, Baicheng Chen, Jia Hao, Chuan Qin, Wei Cheng, Renguo Wen
BACKGROUND: Atrial fibrillation (AF) is a common arrhymia, and it results in increased risk of thromboembolism and decreased cardiac function. In patients undergoing cardiac surgery, concomitant radiofrequency ablation to treat AF is effective in restoring sinus rhythm (SR). This study is an observational cohort study aimed to investigate the safety and efficacy of bipolar radiofrequency ablation (BRFA) for treating AF combined with heart valve diseases. METHODS: Clinical data were analyzed retrospectively from 324 cases of rheumatic heart disease combined with persistent AF patients who underwent valve replacement concomitant BRFA...
2014: BMC Surgery
Lucio Careddu, Antonio Pantaleo, Carlo Savini, Marco Di Eusanio, Ornella Leone, Roberto Di Bartolomeo
Cystic tumor in the atrioventricular (AV) node region is a rare cardiac primary tumor that can lead to sudden death. Our patient was a 43-year-old woman who presented with dyspnea and a first-degree AV block seen on electrocardiography. Echocardiography revealed a cystic mass attached to the inferior portion of the interatrial septum. After surgical excision of the mass, placement of a permanent pacemaker was required for complete heart blockage. Histopathologic examination revealed the mass to be a cystic tumor of the AV node region...
November 2013: Annals of Thoracic Surgery
Surat Tongyoo, Chairat Permpikul, Ratchada Haemin, Nantawan Epichath
BACKGROUND: Cardiac arrhythmia is an important complication of critically ill patients, especially in perioperative period and early after myocardial infarction. However, the information regarding this condition in medical critically ill without active coronary artery disease patients is limited. OBJECTIVE: To identify the predictive factors, incidence, and prognosis of tachyarrhythmia and bradyarrhythmia in non-coronary critically ill medical patients. MATERIAL AND METHOD: A single center prospective cohort study, included medical critically ill patients, age > or = 18 year-old, admitted in a 15-bed medical ICU between September 2010 and August 2011...
February 2013: Journal of the Medical Association of Thailand, Chotmaihet Thangphaet
Robert H Anderson, Diane E Spicer, Anthony J Hlavacek, Alex Hill, Marios Loukas
One of the first principles taught to medical students when they begin their study of human anatomy is that all structures within the body should be described as seen in the anatomical position. In this position, the subject is standing upright and facing the observer. The observer then views left-sided structures to the right hand and right-sided structures to the left hand. Those entities closest to the head are said to be superior, while those closest to the feet are considered to be inferior. And structures within the chest adjacent to the sternum are appropriately described as being anterior, with those adjacent to the spine properly being considered to be posterior...
April 2013: Journal of Cardiovascular Translational Research
Raúl Coma Samartín, María José Sancho-Tello de Carranza, Francisco Ruiz Mateas, Juan Leal del Ojo González, María Luisa Fidalgo Andrés
INTRODUCTION AND OBJECTIVES: To describe the results of the analysis of pacemaker implantations reported to the Spanish Pacemaker Registry in 2011, with particular reference to the population distribution and the selection of pacing modes. METHODS: Information provided by the European Pacemaker Patient Identification Card was processed using a purpose-built computer application. RESULTS: Data from 115 hospitals were analyzed, totaling 13,373 cards, representing an estimated 38% of implantations...
December 2012: Revista Española de Cardiología
Ansheng Mo, Zhaoke Wen, Hui Lin, Changchao Lu, Shengjin Liang
BACKGROUND: The primary aims of minimally-invasive cardiac valve surgery are to lessen the impact of the incision, extracorporeal circulation, myocardial ischemia, and pulmonary ischemia, to obtain satisfactory therapeutic results, and to allow a quicker rehabilitation. In this study, the feasibility of minimally-invasive mitral valve replacements without ascending aorta and vena cava cross-clamping under beating heart was evaluated by surveying 11 patients. METHODS: Preoperative risk factors, intraoperative techniques, and postoperative complications were surveyed and evaluated for one year (April 1, 2009 to March 30, 2010) in 11 patients who had undergone beating-heart mitral valve replacement surgery at The People's Hospital of Guangxi Zhuang Autonomous Region...
June 2012: Heart Surgery Forum
X Laqueille, S Richa, H Kerbage, C Scart-Gres, M-P Berleur
INTRODUCTION: For the past 40 years, methadone has been known to be an efficient treatment of substitution. Its use allowed a significant reduction in the mortality related to opioid addiction. Since 2001, many articles have reported some cases of syncope, wave burst arrhythmia, ventricular tachycardia due to prolonged QT interval and sudden death secondary to cardiac arrest, with a risk of prolongation of the QT interval above 440 ms (men) and 460 ms (women). Many explorations have helped in understanding the physiopathology by showing that opioids, including methadone, cause a blockage of the potassium channels of the gene HERG K+P...
February 2012: L'Encéphale
Ching-Hsiang Lin, Shih-Hung Tsai, Hsiang-Cheng Chen, Sy-Jou Chen
Cavitary lesions on a chest radiograph can be the manifestations of various diseases. The etiologies include abscess, mycobacterial infections, fungal infections, parasite infection, cavitary tumors, septic pulmonary embolism and vasculitis. While in comparison with the causes that could simultaneously develop a complete heart block, the differential diagnosis is limited. A 43-year-old man presented to the emergency department with a two-week history of dry cough, chest tightness and presyncopal symptoms.A chest radiograph showed patchy opacities in both lower lungs...
October 2012: American Journal of Emergency Medicine
Julio Sánchez Román, Celia Ocaña Medina, Francisco J García Hernández, Rocío González León, Rocío Garrido Rasco, Regina Colorado Bonilla, Francisca González Escribano, Ingeborg Wichmann
BACKGROUND AND OBJECTIVE: Congenital complete atrioventricular heart block (CHB) is due to the lesion of the cardiac conduction system by specific transplacental antibodies of maternal origin. In adults with systemic lupus erythematosus (SLE), cardiac toxicity is very questionable and has been related to treatment with synthetic antimalarial drugs (AM). Here we evaluate, in our geographic area, the presence of non congenital CHB in adult patients with SLE and its possible association with AM treatment...
November 2006: Reumatología Clinica
Ling Li, Guang-fu Dong, Feng-zhen Han, Yang Cui, Yun-zhen Shi, Xiao Zhang
OBJECTIVE: To acquire more knowledge about neonatal lupus erythematosus (NLE). METHOD: Seven cases with neonatal lupus erythematosus who were seen in this hospital from 1990 to 2009 are reported in this paper and 87 cases reported previously from 1980 to now in China were reviewed. The clinical manifestations, serum autoantibodies, treatment and results of long-term follow-up are analyzed and summarized. RESULT: Totally 94 cases were summarized...
February 2011: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
Li Feng, Jing Gong, Zhen-yi Jin, Ning Li, Li-ping Sun, Yi-ling Wu, Jie-lin Pu
BACKGROUND: Shen song Yang xin (SSYX) is a compound of Chinese medicine with the effect of increasing heart rate (HR). This study aimed to evaluate its electrophysiological properties at heart and cellular levels. METHODS: The Chinese miniature swines were randomly assigned to two groups, administered with SSYX or placebo for 4 weeks (n = 8 per group). Cardiac electrophysiological study (EPS) was performed before and after drug administration. The guinea pig ventricular myocytes were enzymatically isolated and whole cell voltage-clamp technique was used to evaluate the effect of SSYX on cardiac action potential (AP)...
July 5, 2009: Chinese Medical Journal
Dror Mevorach, Uriel Elchalal, Azaria J J T Rein
PURPOSE OF REVIEW: To describe the results of two recent prospective studies that may indicate how to monitor, diagnose, and treat fetuses with neonatal lupus manifesting with heart involvement and to summarize additional research reports regarding the pathophysiology and outcomes of this rare condition. RECENT FINDINGS: The PR Interval and Dexamethasone Evaluation study found 10 cases of neonatal lupus (10%) with three first-degree atrioventricular blocks (AVBs) and three complete heart blocks...
September 2009: Current Opinion in Rheumatology
Jialong Guo, Shunqing Zuo, Chenyi Lin, Yanmei Ji
Cystic tumor of the atrioventricular nodal region is a rare cardiac primary tumor that can cause heart blockage and sudden death. Antemortem diagnosis and successful excision of the atrioventricular nodal region are extremely rare. A 41-year-old woman who presented with dyspnea and palpitations is reported. Electrocardiography revealed third-degree atrioventricular block. Echocardiography showed a right atrial cystic mass attached to the interatrial septum. The patient underwent surgical excision of the mass...
May 2009: Interactive Cardiovascular and Thoracic Surgery
Po Kwok Chan, Chun Chi Lin, Shuk Han Cheng
BACKGROUND: Zebrafish (Danio rerio), due to its optical accessibility and similarity to human, has emerged as model organism for cardiac research. Although various methods have been developed to assess cardiac functions in zebrafish embryos, there lacks a method to assess heartbeat regularity in blood vessels. Heartbeat regularity is an important parameter for cardiac function and is associated with cardiotoxicity in human being. Using stereomicroscope and digital video camera, we have developed a simple, noninvasive method to measure the heart rate and heartbeat regularity in peripheral blood vessels...
2009: BMC Biotechnology
Mustafa Tok, Mehmet Oc, Halil Ibrahim Ucar, Omer Faruk Dogan, Arda Ozyuksel, Baris Kaya, Mustafa Bora Farsak, Ali Cem Yorgancioglu
Cardiac myxomas are rare benign tumors of the heart. The growth rate of these tumors remains unknown. Right atrial myxoma can simulate nonspecific constitutional symptoms, such as remittent or lasting fever, weight loss, and chronic anemia, and may escape timely diagnosis until the development of severe complications such as pulmonary hypertension due to embolism from fragments originating from the tumor mass or blockage of the right atrioventricular ostium or Budd-Chiari syndrome with acute abdominal pain...
2007: Heart Surgery Forum
Gustavo José Von Glehn dos Santos, Eduardo Hatschbach, Ewaldo de Mattos Júnior, Flávio Massone
PURPOSE: To evaluate the parameters of dogs anesthetized by different dissociative drugs protocols through continuous intravenous infusion. METHODS: Thirty healthy dogs of both sexes were assigned randomly to three groups (G1, G2, and G3). G1 was administered with methotrimeprazine as a pre-anesthetic medication, intravenously midazolam-ketamine as bolus for induction and midazolam-ketamine by continuous intravenous infusion for a 60 minute-period of maintenance...
September 2006: Acta Cirúrgica Brasileira
Shunsuke Saito, Junjiro Kobayashi, Osamu Tagusari, Ko Bando, Kazuo Niwaya, Hiroyuki Nakajima, Masakazu Yamagishi, Toshikatsu Yagihara, Soichiro Kitamura
Cystic tumor of the atrioventricular nodal region is a rare cardiac primary tumor that can cause heart blockage and sudden death. Antemortem diagnosis and successful excision of the atrioventricular nodal region are extremely rare. A 45-year-old woman who presented with palpitations is reported. Electrocardiography revealed first-degree atrioventricular block. Echocardiography, computed tomography, and magnetic resonance imaging scans revealed a cystic mass attached to the interatrial septum. Complete surgical excision of the mass was achieved, although placement of a permanent pacemaker was required for complete heart blockage...
October 2005: Circulation Journal: Official Journal of the Japanese Circulation Society
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