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marihuana heart rate

K P Lindsey, S E Lukas, R R MacLean, E T Ryan, K R Reed, B deB Frederick
Several popularly abused drugs, such as nicotine (tobacco) and THC (delta9-tetrahydrocannabinol) (marihuana) are commonly self-administered by the smoked route. Although the neuronal substrates mediating the effect of smoked drugs are of interest, studies of their acute actions in living human brain has been difficult due to the unique constraints imposed by neuroimaging equipment and scanning environments. We have previously reported a device for the self-administration of smoked drugs with concurrent blood oxygen level dependent (BOLD) fMRI imaging...
January 2009: Clinical EEG and Neuroscience: Official Journal of the EEG and Clinical Neuroscience Society (ENCS)
David M Penetar, Elena M Kouri, Michelle M Gross, Elissa M McCarthy, Christina K Rhee, Erica N Peters, Scott E Lukas
Despite the fact that tobacco and marihuana are often used together, relatively little is known about the effects of this combination. In order to investigate the effects of the principal psychoactive component in tobacco smoke, nicotine, on marihuana-induced intoxication, we conducted a double blind, cross-over experiment using nicotine transdermal patches. Ten male and 10 female participants received either placebo or a 21 mg transdermal nicotine patch 4 h before smoking one of two marihuana cigarettes (1...
August 1, 2005: Drug and Alcohol Dependence
Gabriel G. Nahas
A pleasant sensory perception (PSP), the high of THC or of marihuana consumption, is a consistent functional response to this drug only manifested by man, and which occurs concurrently with an increased heart rate. However, it has not been possible to relate consistently magnitude and duration of these functional markers to THC plasma concentration, whatever the route of administration. A re-analysis of all the available clinical and experimental data reporting the pharmacokinetics and storage of THC in tissues in function of time, have indicated that the discrepancies between functional responses and plasma molecular THC concentration may be accounted for by the pharmacokinetics of THC...
April 2001: Human Psychopharmacology
S E Lukas, M Sholar, E Kouri, H Fukuzako, J H Mendelson
The reasons why individuals use this combination are not entirely clear, however, it has been speculated that marihuana may potentiate cocaine's subjective effects. Five male recreational drug users provided informed consent and volunteered to participate in this study. Each subject participated on 3 different days, separated by at least 1 week. Subjects sat in an isolated chamber and were prepared with electrocardiographic (ECG) electrodes for heart rate monitoring and an IV catheter for blood withdrawal. After adapting to the experimental chamber, they smoked a marihuana cigarette containing either 0...
July 1994: Pharmacology, Biochemistry, and Behavior
J C Merritt, W J Crawford, P C Alexander, A L Anduze, S S Gelbart
Marihuana inhalation was accompanied by increased heart rate and decreased intraocular and blood pressure in 18 subjects with heterogenous glaucomas. The hypotensive effects appeared in 60 to 90 minutes as the decrease in intraocular pressure (IOP) appeared to follow the decrease in blood pressure. In addition to any local effect, the mechanism of lowered to any local effect, the mechanism of lowered IOP may also involve the decreased pressure perfusing the ciliary body vasculature as a result of the peripheral vasodilatory properties of marihuana...
March 1980: Ophthalmology
L L Miller, D M Cocchetto, M Perez-Reyes
This study explored the relationships in man between various pharmacological effect of delta 9-tetrahydrocannabinol (THC), plasma THC concentration, and pharmacokinetic parameters of THC. Three male and three female experienced marihuana users smoked two standard marihuana cigarettes. The relationships between heart rate, subjective "high" rating, Linear Mood Scale factors, and plasma THC concentration were assessed. Significant correlations were observed between various Linear Mood Scale factors and pharmacokinetic parameters reflecting the magnitude of drug intake and the degree of temporal dissociation between the time courses of plasma THC concentration and pharmacological effects (tachycardiac effect, "high")...
1983: European Journal of Clinical Pharmacology
M Perez-Reyes, S Di Guiseppi, K H Davis, V H Schindler, C E Cook
Marihuana cigarettes containing 1.32%, 1.97%, and 2.54% delta 9-tetrahydrocannabinol (THC) were smoked by six experienced marihuana users at weekly intervals in a double-blind cross-over design under laboratory conditions. Puff duration, number of puffs taken, duration of inhalation holding, interval between puffs, and duration of smoking were recorded for each cigarette smoked. The portion of each cigarette remaining after smoking was weighed and analyzed to determine THC content. Subjective ratings of the "high" achieved and the heart rate acceleration induced by smoking the marihuana were measured...
May 1982: Clinical Pharmacology and Therapeutics
D M Cocchetto, S M Owens, M Perez-Reyes, S DiGuiseppi, L L Miller
The relationship between each of two pharmacologic effects (tachycardia and psychological "high") of delta-9-tetrahydrocannabinol (THC) and plasma THC concentration was investigated in three male and three female experienced marihuana smokers. Each subject smoked 1% THC cigarette on two occasions separated by 2 h. Heart rate and subjective psychological self-rating were determined frequently throughout the 4 h study period. Data were analyzed by calculating the area under the parameter versus time curves, constructing hysteresis plots, and calculating the decay rate constants from pharmacologic effect versus time plots...
1981: Psychopharmacology
M Perez-Reyes, S M Owens, S Di Guiseppi
We have studied the dynamics of marihuana smoking, the plasma concentration of delta 9-tetrahydrocannabinol (THC), and the pharmacologic effects produced by the sequential smoking of two 1% marihuana cigarettes at a 2-hour interval. Three males and three females, experienced marihuana smokers, participated in the study. The results indicate that each subject smoked his or her two cigarettes at a similar rate. The THC plasma concentrations produced by the smoking of the second cigarette were slightly lower than those produced by the first cigarette...
August 1981: Journal of Clinical Pharmacology
P F Renault, C R Schuster, R Heinrich, D X Freeman
A spirometer was used to deliver marihuana and placebo smoke to human subjects. This procedure produced linear dose-effect curves on heart rate and replicable dose effects in individual subjects. No differences were observed between experienced and inexperienced smokers in responsiveness to heart rate increases produced by marihuana.
November 5, 1971: Science
(no author information available yet)
No abstract text is available yet for this article.
November 9, 1972: New England Journal of Medicine
H Cappell, C D Webster, B S Herring, R Ginsberg
No abstract text is available yet for this article.
August 1972: Journal of Pharmacology and Experimental Therapeutics
L Lemberger, R E Crabtree, H M Rowe
11-Hydroxy-Delta(9)-tetrahydrocannabinol, administered intravenously to man, produces psychologic and pharmacologic effects that persist for several hours. The drug and its metabolites are excreted in urine and feces for more than 1 week. The pharmacology, disposition, and metabolism of 11-hydroxy-Delta(9)-tetra-hydrocannabinol mimic that of Delta(9)-tetrahydrocannabinol, thus providing evidence that Delta(9)-tetrahydrocannabinol (the major active component of marihuana) is converted to the 11-hydroxy compound in man, the latter compound being responsible for the effects...
July 7, 1972: Science
E Sánchez, L Tampier, L Núñez, J Mardones
No abstract text is available yet for this article.
March 1972: Revista Médica de Chile
R B Forney
No abstract text is available yet for this article.
December 1971: Pharmacological Reviews
S Johnson, E F Domino
No abstract text is available yet for this article.
September 1971: Clinical Pharmacology and Therapeutics
J E Manno, G F Kiplinger, N Scholz, R B Forney
No abstract text is available yet for this article.
March 1971: Clinical Pharmacology and Therapeutics
A T Weil, N E Zinberg, J M Nelsen
No abstract text is available yet for this article.
December 13, 1968: Science
S C Clark, C Greene, G W Karr, K L MacCannell, S L Milstein
No abstract text is available yet for this article.
June 1974: Canadian Journal of Physiology and Pharmacology
P F Renault, C R Schuster, D X Freedman, B Sikic, D N de Mello
No abstract text is available yet for this article.
July 1974: Archives of General Psychiatry
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