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Ulipristal acetate

Jacques Donnez, Olivier Donnez, Marie-Madeleine Dolmans
During the last decade, there has been increased emphasis on the role of progesterone in the promotion of fibroid growth, as well as heightened interest in modulating progesterone pathways by use of selective progesterone receptor modulators (SPRMs). Among them, ulipristal acetate (UPA) has proved its efficacy in the management of symptomatic myomas by controlling bleeding and inducing amenorrhea, and reducing the size of myomas in the majority of cases. Areas covered: In this review, we summarize published scientific studies exploring evidence of the safety of SPRMs and particularly UPA, a drug approved for the management of symptomatic uterine fibroids...
October 14, 2016: Expert Opinion on Drug Safety
N A Leyland
No abstract text is available yet for this article.
November 2015: Journal of Minimally Invasive Gynecology
A Murji, R Crosier, W Wolfman, J Shapiro
No abstract text is available yet for this article.
November 2015: Journal of Minimally Invasive Gynecology
S Ferrero, E Tafi, A Racca, Roberti Leone, U Maggiore, V Remorgida, P L Venturini
No abstract text is available yet for this article.
November 2015: Journal of Minimally Invasive Gynecology
S Ferrero, A Racca, E Tafi, F Sozzi, U Leone Roberti Maggiore, V Remorgida, P L Venturini
No abstract text is available yet for this article.
November 2015: Journal of Minimally Invasive Gynecology
Wing Kay Fok, Paul D Blumenthal
PURPOSE OF REVIEW: Emergency contraception provides a critical and time-sensitive opportunity for women to prevent undesired pregnancy after intercourse. Both access and available options for emergency contraception have changed over the last several years. RECENT FINDINGS: Emergency contraceptive pills can be less effective in obese women. The maximum achieved serum concentration of levonorgestrel (LNG) is lower in obese women than women of normal BMI, and doubling the dose of LNG (3 mg) increases its concentration maximum, approximating the level in normal BMI women receiving one dose of LNG...
September 24, 2016: Current Opinion in Obstetrics & Gynecology
Elena de la Fuente, María Dolores Borrás, Miriam Rubio, Nuria Abril
The use of ulipristal acetate (UPA) has been recently introduced in the treatment of uterine leiomyomas. This drug has proven useful to control menometrorrhagia and to reduce myoma size. In the case presented here, we show the benefits of UPA treatment in facilitating surgical removal of giant myomas in an infertile patient. In addition to myoma reduction and a better control of preoperative bleeding, the treatment with UPA reduced the duration and complexity of the surgery, as well as the area of uterine wall involved and the resulting scar...
2016: Case Reports in Medicine
Simone Ferrero, Franco Alessandri, Valerio Gaetano Vellone, Pier Luigi Venturini, Umberto Leone Roberti Maggiore
OBJECTIVE: To assess the usefulness of 3-month treatment with ulipristal acetate (UPA) before laparoscopic myomectomy of large uterine myomas. STUDY DESIGN: This retrospective analysis of a prospectively collected database included women of reproductive age requiring laparoscopic myomectomy with the following characteristics: FIGO type 3, 4 or 5 myomas; largest diameter of the main myoma ≥10cm; number of myomas ≤3; largest diameters of the other myomas ≤5cm (second myoma) and ≤3cm (third myoma)...
October 2016: European Journal of Obstetrics, Gynecology, and Reproductive Biology
Kathryn M Curtis, Naomi K Tepper, Tara C Jatlaoui, Erin Berry-Bibee, Leah G Horton, Lauren B Zapata, Katharine B Simmons, H Pamela Pagano, Denise J Jamieson, Maura K Whiteman
The 2016 U.S. Medical Eligibility Criteria for Contraceptive Use (U.S. MEC) comprises recommendations for the use of specific contraceptive methods by women and men who have certain characteristics or medical conditions. These recommendations for health care providers were updated by CDC after review of the scientific evidence and consultation with national experts who met in Atlanta, Georgia, during August 26-28, 2015. The information in this report updates the 2010 U.S. MEC (CDC. U.S. medical eligibility criteria for contraceptive use, 2010...
2016: MMWR. Recommendations and Reports: Morbidity and Mortality Weekly Report. Recommendations and Reports
Ally Murji, Rebecca Crosier, Tiffany Chow, Xiang Y Ye, Lindsay Shirreff
OBJECTIVE: To study differences in treatment effect between black and white premenopausal women prescribed ulipristal acetate (UPA) for symptomatic uterine fibroids. DESIGN: Prospective observational cohort study. SETTING: Gynecology clinics. PATIENT(S): Premenopausal women aged 18-55 years, at least one symptomatic uterine fibroid, UPA-naïve, and no contraindications for UPA treatment. INTERVENTION(S): One 3-month course of UPA at 5 mg daily...
June 20, 2016: Fertility and Sterility
Pelin Batur, Lisa N Kransdorf, Petra M Casey
Emergency contraception (EC) may help prevent pregnancy in various circumstances, such as contraceptive method failure, unprotected sexual intercourse, or sexual assault, yet it remains underused. There are 4 approved EC options in the United States. Although ulipristal acetate requires a provider's prescription, oral levonorgestrel (LNG) is available over the counter for women of all ages. The most effective method of EC is the copper intrauterine device, which can be left in place for up to 10 years for efficacious, cost-effective, hormone-free, and convenient long-term primary contraception...
June 2016: Mayo Clinic Proceedings
Tara C Jatlaoui, Kathryn M Curtis
OBJECTIVE: This study aims to determine whether emergency contraceptive pills (ECPs) are less safe and effective for women with obesity compared with those without obesity. STUDY DESIGN: We searched PubMed for articles through November 2015 regarding the safety and effectiveness of ECPs [ulipristal acetate (UPA), levonorgestrel (LNG) and combined estrogen and progestin] among obese users. We assessed study quality using the United States Preventive Services Task Force evidence grading system...
May 24, 2016: Contraception
R Schmid
No abstract text is available yet for this article.
November 2014: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
L Lorenzovici, A Székely, T Ágh, I Vámossy, L J Kelemen, H Finta, Z Kaló
No abstract text is available yet for this article.
November 2014: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
Stefan Cosyns, Noelie Dony, Nikolaos P Polyzos
No abstract text is available yet for this article.
May 18, 2016: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
Gary Levy, John Elkas, Alicia Y Armstrong, Lynnette K Nieman
BACKGROUND: Prolonged exposure to a selective progesterone receptor modulator (ulipristal acetate) in a patient with benign metastasizing leiomyoma did not result in endometrial hyperplasia or neoplasia. CASE: A woman with history of benign metastasizing leiomyoma underwent medical treatment for 5 years with ulipristal acetate. Endometrial biopsies were performed at established intervals to monitor for intraepithelial neoplasia or progesterone receptor modulator-associated endometrial changes (PAECs)...
March 2016: Journal of Reproductive Medicine
A Willame, R Marci, P Petignat, J Dubuisson
OBJECTIVE: Uterine myomas are one of the most common benign tumours, occurring in 20-40% of women of reproductive age. Ulipristal acetate (UPA) is a possible option for medical treatment of myomas. It induces amenorrhea and can reduce myoma volume before surgical treatment. Since its introduction in our department, we uncovered an unknown effect: migration of myoma. CLINICAL CASE REPORTS: We describe three clinical case of myoma migration following three months UPA pre-operative treatment...
April 2016: European Review for Medical and Pharmacological Sciences
Niklas Envall, Nina Groes Kofoed, Helena Kopp-Kallner
INTRODUCTION: Emergency contraception must be followed by the use of an effective method of contraception in order to reduce future risk of unintended pregnancies. Provision of long-acting reversible contraception (LARC) is highly effective in this regard. The aim of our study was to compare use of an effective method of contraception 6 months following insertion of a copper intrauterine device (Cu-IUD) or intake of ulipristal acetate (UPA) for emergency contraception (EC). MATERIAL AND METHODS: Women (n = 79) presenting with need for EC at an outpatient midwifery clinic chose either Cu-IUD or UPA according to preference...
August 2016: Acta Obstetricia et Gynecologica Scandinavica
Anita Olejek, Katarzyna Olszak-Wąsik, Anna Czerwinska-Bednarska
Uterine fibroids are found in almost 20-40% of women of reproductive age. For each woman an individualised treatment method should be applied because the hysterectomy procedure is not a good option in every case. The uterus is an organ necessary not only in reproduction. Its removal may result in: pelvic floor dysfunction and stress urinary incontinence, negative impair on life quality, depressive disorders, increased risk of cardiovascular and neurodegenerative diseases, and higher incidence of neoplastic disease...
March 2016: Przeglad Menopauzalny, Menopause Review
Oukseub Lee, Mi-Ran Choi, Konstantin Christov, David Ivancic, Seema A Khan
PURPOSE: Blockade of the progestogen-progesterone receptor (PR) axis is a novel but untested strategy for breast cancer prevention. We report preclinical data evaluating telapristone acetate (TPA), ulipristal acetate (UPA), and mifepristone. METHODS: Tumors were induced with medroxyprogesterone acetate (MPA) plus 7,12-dimethylbenz[a]anthracene (DMBA) in mice, and MPA or progesterone plus N-methyl-N-nitrosourea (MNU) in rats. Mammary gland histology, tumor incidence, latency, multiplicity, burden and histology were evaluated, along with immunohistochemical labeling of pHH3 (proliferation), CD34 (angiogenesis), and estrogen and progesterone receptors (ER and PR)...
July 1, 2016: Cancer Letters
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