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Ulipristal acetate

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https://www.readbyqxmd.com/read/27918164/-the-possibility-of-using-progesterone-receptor-modulators-in-the-treatment-of-myomas
#1
O Šimetka, J Klát, S Bajsová
OBJECTIVE: To summarize the knowledge about the effect of selective progesterone receptor modulators and their use in the treatment of myomas in women of childbearing age and in perimenopause. DESIGN: Review article. RESULTS: Long-term treatment with ulipristal acetate maximizes its effectiveness, it helps to achieve faster bleeding control and increases the number of pa-tients with fibroid volume reduction of more than 50%. Ulipristal acetate is the most effective drug in the medical treatment of myomas and its use will change the approach to surgical treatment...
2016: Ceská Gynekologie
https://www.readbyqxmd.com/read/27914766/histomorphological-changes-in-endometriosis-in-a-patient-treated-with-ulipristal-a-case-report
#2
J Bateman, O Bougie, S Singh, S Islam
BACKGROUND: Selective progesterone receptor modulators have shown efficacy in the treatment of endometriosis, however they are not currently licensed in Canada for this purpose. Their histomorphological effects have been well documented in the endometrium, but not in endometriosis. CASE REPORT: The patient presented with uterine fibroids and heavy menstrual bleeding, and was treated with ulipristal acetate over three 90-day courses. She eventually elected to undergo definitive surgical management...
October 25, 2016: Pathology, Research and Practice
https://www.readbyqxmd.com/read/27898340/real-world-data-of-1473-patients-treated-with-ulipristal-acetate-for-uterine-fibroids-premya-study-results
#3
Hervé Fernandez, Torsten Schmidt, Martin Powell, Ana Patrícia Freitas Costa, Pablo Arriagada, Christian Thaler
OBJECTIVES: To characterize and describe treatment with Ulipristal acetate (UPA) in a pre-operative setting and to evaluate the safety, effectiveness, and Health Related Quality of Life (HRQoL) outcomes in a population treated according to standard clinical practice in the EU. STUDY DESIGN: Multi-centre, prospective, non-interventional study (PREMYA) of patients diagnosed with moderate to severe symptoms of uterine fibroids and undergoing a pre-operative treatment with UPA (Esmya(®)) at 73 clinical practice sites within the EU...
November 19, 2016: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/27896473/experience-with-oral-emergency-contraception-since-the-otc-switch-in-germany
#4
Marion Kiechle, Miriam Neuenfeldt
PURPOSE: In March 2015, the oral emergency contraceptives levonorgestrel (LNG) and ulipristal acetate (UPA) were released from prescription-only status in Germany. The main research question is to analyse whether the OTC status of oral emergency contraceptives has an influence on the patterns of use. METHODS: All information is based on searches for public domain sources on emergency contraception. Searches were made for scientific publications, statistics, and surveys...
November 28, 2016: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/27889055/medical-or-surgical-management-of-fibroids-an-internet-survey-of-gynecologists-views
#5
Elisa Pazzaglia, Julie Praet, Jean Vandromme, Serge Rozenberg
AIM: To assess the attitudes of gynecologists toward symptomatic fibroids and analyze which factors influence their choice of treatment. MATERIAL AND METHOD: We surveyed the attitude of Belgian gynecologists toward patients' cases. We used a vignette of a woman with symptomatic fibroids and modified 3 factors: her age, her parity and her desire for pregnancy, thereby establishing 12 different cases. We ensured that each gynecologist (n=1437) received one case, chosen randomly, by email...
January 2017: Maturitas
https://www.readbyqxmd.com/read/27882756/-the-use-of-selective-progesterone-receptor-modulators-in-the-treatment-of-myomas
#6
O Šimetka, J Klát
OBJECTIVE: To summarize the knowledge of the effect of selective progesterone receptor modulators and their use in the treatment of myomas in women of childbearing age and in perimenopause. DESIGN: Review articleResults: Long-term treatment with ulipristal acetate maximizes its effectiveness, it helps to achieve faster bleeding control and increases the number of patients with fibroid volume reduction of more than 50%. Ulipristal acetate is the most effective drug in the medical treatment of myomas and its use will change the approach to surgical treatment...
2016: Ceská Gynekologie
https://www.readbyqxmd.com/read/27786570/ulipristal-acetate-for-pre-operative-treatment-of-moderate-to-severe-uterine-fibroids-in-women-of-reproductive-age-in-the-netherlands-cost-minimization-analysis-and-budget-impact-analysis
#7
N Zakiyah, A D I van Asselt, M J Postma
OBJECTIVE: Ulipristal acetate has been found to be non-inferior to other pre-operative treatments of uterine fibroids, particularly leuprolide. The objective of this study was to assess the pharmacoeconomic profile of ulipristal acetate compared to leuprolide for the pre-operative treatment of moderate-to-severe uterine fibroids in women of reproductive age in The Netherlands. The analysis was performed and applied within the framework of the ulipristal acetate submission for reimbursement in 2012...
November 11, 2016: Journal of Medical Economics
https://www.readbyqxmd.com/read/27785169/non-prescription-dispensing-of-emergency-oral-contraceptives-recommendations-from-the-german-federal-chamber-of-pharmacists-bundesapothekerkammer
#8
Martin Schulz, Ralf Goebel, Claudia Schumann, Petra Zagermann-Muncke
BACKGROUND: Emergency hormonal contraceptives (EHC) are contraceptives used to prevent unintended pregnancy following unprotected sexual intercourse (USI) or contraceptive failure. The EHCs available without a prescription include medicines containing levonorgestrel (LNG) in more than 80 countries and, recently, based on an EU-switch ellaOne®, which contains ulipristal acetate (UPA). EHCs work by stopping or delaying ovulation. Those containing LNG can be used up to 72 hours after USI or contraceptive failure, while UPA can be used up to 120 hours...
July 2016: Pharmacy Practice
https://www.readbyqxmd.com/read/27769767/-i-don-t-know-what-i-would-have-done-women-s-experiences-acquiring-ulipristal-acetate-emergency-contraception-online-from-2011-to-2015
#9
Nicole K Smith, Kelly Cleland, Brandon Wagner, James Trussell
OBJECTIVES: This study describes women's reasons for seeking ulipristal acetate (UPA) for emergency contraception (EC) through the only authorized online retailer for UPA EC in the US. STUDY DESIGN: Women aged 14 to 59 years, living in states that allow prescription medications to be shipped from out-of-state, accessed the KwikMed online pharmacy between January 2011 and December 2015. After completing a medical eligibility screener, women answered optional multiple-choice questions...
October 18, 2016: Contraception
https://www.readbyqxmd.com/read/27740868/safety-of-treatment-of-uterine-fibroids-with-the-selective-progesterone-receptor-modulator-ulipristal-acetate
#10
Jacques Donnez, Olivier Donnez, Marie-Madeleine Dolmans
During the last decade, there has been increased emphasis on the role of progesterone in the promotion of fibroid growth, as well as heightened interest in modulating progesterone pathways by use of selective progesterone receptor modulators (SPRMs). Among them, ulipristal acetate (UPA) has proved its efficacy in the management of symptomatic myomas by controlling bleeding and inducing amenorrhea, and reducing the size of myomas in the majority of cases. Areas covered: In this review, we summarize published scientific studies exploring evidence of the safety of SPRMs and particularly UPA, a drug approved for the management of symptomatic uterine fibroids...
December 2016: Expert Opinion on Drug Safety
https://www.readbyqxmd.com/read/27679325/the-selective-progesterone-receptor-modulator-ulipristal-acetate-in-the-management-of-symptomatic-uterine-fibroids
#11
N A Leyland
No abstract text is available yet for this article.
November 2015: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/27679215/the-role-of-ethnicity-in-the-treatment-of-uterine-fibroids-with-ulipristal-acetate
#12
A Murji, R Crosier, W Wolfman, J Shapiro
No abstract text is available yet for this article.
November 2015: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/27678974/ulipristal-acetate-prior-to-high-complexity-hysteroscopic-myomectomy-prospective-study
#13
S Ferrero, E Tafi, A Racca, Roberti Leone, U Maggiore, V Remorgida, P L Venturini
No abstract text is available yet for this article.
November 2015: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/27678581/3-month-versus-6-month-treatment-with-ulipristal-acetate-prior-to-laparoscopic-hysterectomy-of-large-myomatous-uteri
#14
S Ferrero, A Racca, E Tafi, F Sozzi, U Leone Roberti Maggiore, V Remorgida, P L Venturini
No abstract text is available yet for this article.
November 2015: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/27676405/update-on-emergency-contraception
#15
Wing Kay Fok, Paul D Blumenthal
PURPOSE OF REVIEW: Emergency contraception provides a critical and time-sensitive opportunity for women to prevent undesired pregnancy after intercourse. Both access and available options for emergency contraception have changed over the last several years. RECENT FINDINGS: Emergency contraceptive pills can be less effective in obese women. The maximum achieved serum concentration of levonorgestrel (LNG) is lower in obese women than women of normal BMI, and doubling the dose of LNG (3 mg) increases its concentration maximum, approximating the level in normal BMI women receiving one dose of LNG...
December 2016: Current Opinion in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/27594886/ulipristal-acetate-in-myomectomy-optimization-in-an-infertile-patient-with-giant-myomas
#16
Elena de la Fuente, María Dolores Borrás, Miriam Rubio, Nuria Abril
The use of ulipristal acetate (UPA) has been recently introduced in the treatment of uterine leiomyomas. This drug has proven useful to control menometrorrhagia and to reduce myoma size. In the case presented here, we show the benefits of UPA treatment in facilitating surgical removal of giant myomas in an infertile patient. In addition to myoma reduction and a better control of preoperative bleeding, the treatment with UPA reduced the duration and complexity of the surgery, as well as the area of uterine wall involved and the resulting scar...
2016: Case Reports in Medicine
https://www.readbyqxmd.com/read/27566221/three-month-treatment-with-ulipristal-acetate-prior-to-laparoscopic-myomectomy-of-large-uterine-myomas-a-retrospective-study
#17
Simone Ferrero, Franco Alessandri, Valerio Gaetano Vellone, Pier Luigi Venturini, Umberto Leone Roberti Maggiore
OBJECTIVE: To assess the usefulness of 3-month treatment with ulipristal acetate (UPA) before laparoscopic myomectomy of large uterine myomas. STUDY DESIGN: This retrospective analysis of a prospectively collected database included women of reproductive age requiring laparoscopic myomectomy with the following characteristics: FIGO type 3, 4 or 5 myomas; largest diameter of the main myoma ≥10cm; number of myomas ≤3; largest diameters of the other myomas ≤5cm (second myoma) and ≤3cm (third myoma)...
October 2016: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/27467196/u-s-medical-eligibility-criteria-for-contraceptive-use-2016
#18
Kathryn M Curtis, Naomi K Tepper, Tara C Jatlaoui, Erin Berry-Bibee, Leah G Horton, Lauren B Zapata, Katharine B Simmons, H Pamela Pagano, Denise J Jamieson, Maura K Whiteman
The 2016 U.S. Medical Eligibility Criteria for Contraceptive Use (U.S. MEC) comprises recommendations for the use of specific contraceptive methods by women and men who have certain characteristics or medical conditions. These recommendations for health care providers were updated by CDC after review of the scientific evidence and consultation with national experts who met in Atlanta, Georgia, during August 26-28, 2015. The information in this report updates the 2010 U.S. MEC (CDC. U.S. medical eligibility criteria for contraceptive use, 2010...
2016: MMWR. Recommendations and Reports: Morbidity and Mortality Weekly Report. Recommendations and Reports
https://www.readbyqxmd.com/read/27336213/role-of-ethnicity-in-treating-uterine-fibroids-with-ulipristal-acetate
#19
Ally Murji, Rebecca Crosier, Tiffany Chow, Xiang Y Ye, Lindsay Shirreff
OBJECTIVE: To study differences in treatment effect between black and white premenopausal women prescribed ulipristal acetate (UPA) for symptomatic uterine fibroids. DESIGN: Prospective observational cohort study. SETTING: Gynecology clinics. PATIENT(S): Premenopausal women aged 18-55 years, at least one symptomatic uterine fibroid, UPA-naïve, and no contraindications for UPA treatment. INTERVENTION(S): One 3-month course of UPA at 5 mg daily...
October 2016: Fertility and Sterility
https://www.readbyqxmd.com/read/27261868/emergency-contraception
#20
REVIEW
Pelin Batur, Lisa N Kransdorf, Petra M Casey
Emergency contraception (EC) may help prevent pregnancy in various circumstances, such as contraceptive method failure, unprotected sexual intercourse, or sexual assault, yet it remains underused. There are 4 approved EC options in the United States. Although ulipristal acetate requires a provider's prescription, oral levonorgestrel (LNG) is available over the counter for women of all ages. The most effective method of EC is the copper intrauterine device, which can be left in place for up to 10 years for efficacious, cost-effective, hormone-free, and convenient long-term primary contraception...
June 2016: Mayo Clinic Proceedings
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