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synovitis alendron

K Gökkus, G Yazicioglu, E Sagtas, A Uyan, A T Aydin
We present a case of polyarticular synovitis following alendronate treatment for osteoporosis. The patient had no evidence of rheumatoid arthritis, pyrophosphate arthropathy, or seronegative/seropositive arthritis. Our main aim in this study is to highlight the potential adverse effects of alendronate and to warn orthopedic surgeons about the possibility of such a side effect that might lead orthopedic surgeons to administer wrong and unnecessary treatments like arthrocentesis. The withdrawal of alendronate is found to be the treatment of choice...
April 2016: Journal of Postgraduate Medicine
Yasuo Suzuki, Takayuki Wakabayashi
Mechanism of generalized osteoporosis associated with rheumatoid arthritis(RA)is multifactorial and following factors has been proposed:systemic effect of RA synovitis, glucocorticoids, weight loss, and endocrine changes. In addition to control of RA inflammation and management of glucocorticoid-induced osteoporosis(GIO), antiresorptive therapy, such as bisphosphonates is expected to show efficacy. Recently, anti-RANKL monoclonal antibodies have been shown to inhibit bone erosion and bone loss in combination with methotrexate in RA...
December 2015: Clinical Calcium
Frederico Barra de Moraes, Tainá Melo Vieira Motta, Alessandra Assis Severin, Deniel de Alencar Faria, Fernanda de Oliveira César, Siderlei de Souza Carneiro
The aim of this study was to report on a rare case of Garré's sclerosing osteomyelitis. The patient was a 54-year-old woman with a history of treatment for lupus using corticoids for 20 years, and for osteoporosis using alendronate for five years. She presented edema and developed a limitation of left knee movement one year earlier, with mild effusion and pain on metaphyseal palpation, but without fever. She was in a good general state, without local secretion. Images of her knee showed trabecular osteolysis of the distal metaphysis of the femur and a periosteal reaction in both proximal tibias and both distal femurs, compatible with chronic osteomyelitis of low virulence and slow progression...
July 2014: Revista Brasileira de Ortopedia
Xinghua Song, Wenwen Sun, Zhaowei Meng, Lu Gong, Jian Tan, Qiang Jia, Chunshui Yu, Tielian Yu
The present study reports a rare case of synovitis, acne, pustulosis, hyperostosis and osteitis (SAPHO) syndrome in an adult male. The 42-year-old man complained of skin lesions, chest pain and lumbago. Laboratory evaluations demonstrated an elevated erythrocyte sedimentation rate and increased levels of C-reactive protein. Computerized tomography, bone scintigraphy and magnetic resonance imaging revealed multiple bone lesions. A diagnosis of SAPHO syndrome was made. Non-steroidal anti-inflammatory drugs, alendronate sodium and steroids were administered, which resulted in clinical improvement...
August 2014: Experimental and Therapeutic Medicine
Gerson Dellatorre, Caio César Silva de Castro
The SAPHO syndrome (synovitis, acne, pustulosis, hyperostosis and osteitis) includes a group of findings characterized by bone lesions usually located on the anterior chest wall, often associated with skin lesions. We report the case of a 47 years old patient, with osteochondritis at costoesternal and manubrium-sternal joints, besides of palmar-plantar pustulosis. The diagnosis is predominantly clinical and there are several treatment options described in the literature.
January 2012: Anais Brasileiros de Dermatologia
L L Zhang, J X Zhao, X Y Liu
SAPHO syndrome (synovitis, acne, pustulosis, hyperostosis, and osteitis) is a rare disease. Presently, there is no treatment guideline for this illness. Several studies suggested entercept, a novel biological agent against tumor necrosis factor-alpha, is effective in treating SAPHO syndrome. We report a case in which the clinical conditions of a middle-aged female patient diagnosed with SAPHO syndrome, with noted spinal disorder, improved significantly after receiving entercept treatment. The patient remained stable after 3-month follow-up...
July 2012: Rheumatology International
David P Gwynne Jones, Ruth L Savage, John Highton
We describe 7 cases of synovitis or arthritis occurring after commencement of alendronate for treatment of osteoporosis. These were cases from our practice or notified to the New Zealand Pharmacovigilance Centre, Dunedin, New Zealand. There was no evidence of rheumatoid arthritis, pyrophosphate arthropathy, or seronegative arthritis in any patient. Symptoms recurred on rechallenge in 5 of the cases. We conclude alendronate should be considered as a possible cause of synovitis or polyarthritis in patients treated with it in the absence of any other pathology...
March 2008: Journal of Rheumatology
Louise Frederiksen, Peter Junker, Kim T Brixen
A 62-year-old, previously healthy woman diagnosed with post-menopausal osteoporosis received alendronate 70 mg/week. One week after the first dose, she developed polyarticular synovitis in the hands, feet and knees. We suspect this to be an adverse reaction to alendronate. At follow-up after 14 months, the patient still had residual synovitis, mainly in the hands and finger joints, despite continued low-dose prednisolone therapy. Two additional cases of synovitis associated with bisphosphonate therapy have been reported in the literature...
April 23, 2007: Ugeskrift for Laeger
(no author information available yet)
No abstract text is available yet for this article.
April 2007: Prescrire International
David Gwynne Jones, Ruth Savage, John Highton
No abstract text is available yet for this article.
January 8, 2005: BMJ: British Medical Journal
M Witzig, St Bützberger, M Caravatti, J Furrer, G Schulthess
HISTORY AND ADMISSION FINDINGS: A 63-year-old female painter was referred for evaluation of the cause of persistent back pain, night sweat and an elevated blood sedimentation rate. Besides, she reported recurrent, probably "atopic eczema" of both hands. Clinical examination revealed midthoracic back pain but no actual skin lesions. INVESTIGATIONS: Contrast medium-enhanced magnetic resonance tomography of the spine showed an increased signal intensity of the thoracic vertebral bodies 6 - 10 and the prevertebral soft tissue in T1-weighted images with fat suppression...
August 22, 2003: Deutsche Medizinische Wochenschrift
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