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hba1c angiography

Shuhei Takahashi, Kazunori Shimada, Katsumi Miyauchi, Tetsuro Miyazaki, Eiryu Sai, Manabu Ogita, Shuta Tsuboi, Hiroshi Tamura, Shinya Okazaki, Tomoyuki Shiozawa, Shohei Ouchi, Tatsuro Aikawa, Tomoyasu Kadoguchi, Hamad Al Shahi, Takuma Yoshihara, Makoto Hiki, Kikuo Isoda, Hiroyuki Daida
BACKGROUND: Postprandial hyperglycemia plays an important role in the pathogenesis of coronary artery disease and cardiovascular events. Serum 1,5-anhydroglucitol (1,5-AG) levels are known to be a clinical marker of postprandial hyperglycemia. However, the impact of 1,5-AG level on cardiovascular events has not been fully investigated. METHODS: We enrolled 240 consecutive patients who had undergone first-time elective percutaneous coronary intervention (PCI) with follow-up angiography within 1 year...
October 11, 2016: Cardiovascular Diabetology
Matteo Nardin, Monica Verdoia, Alon Schaffer, Lucia Barbieri, Paolo Marino, Giuseppe De Luca
BACKGROUND AND AIMS: Growing attention has been addressed to the cardiovascular effects of vitamin D, in order to prevent the vascular wall degeneration and the progression of atherosclerosis. Diabetes mellitus is an established risk factor for coronary artery disease, where the enhanced pro-inflammatory and pro-thrombotic status could render even more important the athero-protective effects of vitamin D. Therefore, we aimed to evaluate the impact of diabetes on vitamin D levels and its relationship with the extent of CAD...
July 2016: Atherosclerosis
Xiao-Li Luo, Qing-Kai Yan, Yan Wang, Hui Fang, Hong-Yong Wang, Yun Bai, Chun-Yu Zeng, Xu-Kai Wang
Insulin is used in the treatment of type 2 diabetes, with its usage reaching 30-50% in Western countries. The aim of the present study was to determine the association between insulin dosage (ID)/insulin usage time (IT) and coronary artery lesions in patients of type 2 diabetes with coronary heart disease. Based on the insulin using dosage, 353 type 2 diabetes patients were divided into the high-dose (≥0.5 IU/kg) and low-dose (<0.5 IU/kg) group. Selected coronary angiography was performed and the Gensini score was used to determine the degree of the coronary artery lesions...
May 2016: Experimental and Therapeutic Medicine
Nagwa A Lachine, Abdel Aziz Elnekiedy, Magdy Helmy Megallaa, Gihane I Khalil, Mohamed A Sadaka, Kamel H Rohoma, Heba S Kassab
CONTEXT: Chemerin is one of the adipokines that regulate fat metabolism. High-sensitivity C-reactive protein (hs-CRP) may be considered as a cardiovascular risk predictor. Measuring intima-media thickness of the CCA (C-IMT) is a well-evidenced tool for the detection of early stages of atherosclerosis. We aimed here to study both serum chemerin and hs-CRP as markers of subclinical atherosclerosis in Egyptian patients with type 2 diabetes, who are angiographically free of coronary artery disease (CAD)...
April 2016: Therapeutic Advances in Endocrinology and Metabolism
Junichi Nishida, Nobuaki Kokubu, Mina Kawamukai, Akiyoshi Hashimoto, Hirofumi Ohnishi, Hidemichi Kouzu, Yoshito Ohnuma, Tohru Hasegawa, Akihito Tsuchida, Tetsuji Miura
OBJECTIVE: Chronic kidney disease is a risk factor of coronary events, however, its impact on coronary artery stenosis has not yet been clarified with the use of a large database. We examined the association between a reduced glomerular filtration rate (GFR) and the overall severity of coronary stenosis. METHODS: We enrolled 1,150 patients [mean age, 68±12 (SD) years; 66.6% men] who consecutively underwent coronary angiography for suspected stable angina pectoris...
2016: Internal Medicine
Michal Laufer Perl, Ariel Finkelstein, Miri Revivo, Shlomo Berliner, Itzhak Herz, Itay Rabinovich, Tomer Ziv-Baran, Dalit Gotler, Gad Keren, Shmuel Bana, Yaron Arbel
BACKGROUND: Atherosclerosis is a systemic disease. Nevertheless, the role of specific biomarkers as indicators for both coronary and carotid diseases is debatable. OBJECTIVES: To evaluate the association of biomarkers with coronary and carotid disease. METHODS: We studied 522 consecutive patients with stable angina. All underwent coronary angiography and carotid duplex study on the same day. Patients with no apparent carotid plaques were evaluated for carotid intima-media thickness (CIMT) using an automated system that sampled over 100 samples in each carotid artery...
February 2016: Israel Medical Association Journal: IMAJ
Ofer Havakuk, Shmuel Banai, Amir Halkin, Maayan Konigstein, Eyal Ben Assa, Shlomo Berliner, Tomer Ziv-Baran, Meital Elbaz, Miri Revivo, Gad Keren, Ariel Finkelstein, Yaron Arbel
OBJECTIVES: Previous studies investigating the prognostic value of HbA1c in patients undergoing coronary angiography reported a mixed pattern of results. Therefore, we aimed to better define the prognostic power of HbA1c among coronary catheterized patients. METHODS: Patients undergoing coronary angiography (n = 3,749) were divided into four groups according to HbA1c levels (<5, 5-6, 6-7 and >7%). Cox regression models assessed long-term mortality after adjusting for multiple covariates...
2016: Cardiology
Sung Bong Shin, Tae Uk Kim, Jung Keun Hyun, Jung Yoon Kim
OBJECTIVE: To elucidate the association between glycemic control status and clinical outcomes in patients with acute ischemic stroke limited to the deep branch of the middle cerebral artery (MCA). METHODS: We evaluated 65 subjects with first-ever ischemic stroke of the deep branches of the MCA, which was confirmed by magnetic resonance angiography. All subjects had blood hemoglobin A1c (HbA1c) measured at admission. They were classified into two groups according to the level of HbA1c (low <7...
December 2015: Annals of Rehabilitation Medicine
Zheng Wang, Hai-Yan Song, Meng-Meng An, Li-Li Zhu
OBJECTIVE: To investigate the association of serum SPARC level with the severity of coronary artery lesion in type 2 diabetic patients with coronary heart disease. METHODS: 120 patients with type 2 diabetic patients were the subjects. Enzyme-linked immunosorbent assay (ELISA) was used to detect levels of serum SPARC and Gensini score was used to assess extent of coronary artery lesions. The patients were divided into 4 groups: A group was the healthy control group with 40 patients...
2015: International Journal of Clinical and Experimental Medicine
Rafael Romaguera, Joan A Gómez-Hospital, Josep Gomez-Lara, Salvatore Brugaletta, Eduardo Pinar, Pilar Jiménez-Quevedo, Montserrat Gracida, Gerard Roura, Jose L Ferreiro, Luis Teruel, Eduard Montanya, Antonio Fernandez-Ortiz, Fernando Alfonso, Marco Valgimigli, Manel Sabate, Angel Cequier
OBJECTIVES: The aim of this study was to compare the efficacy of amphilimus-eluting stents (AES) with that of everolimus-eluting stents (EES) in patients with diabetes mellitus (DM). BACKGROUND: The AES is a polymer-free drug-eluting stent that elutes sirolimus formulated with an amphiphilic carrier from laser-dug wells. This technology could be associated with a high efficacy in patients with DM. METHODS: This was a multicenter, randomized, noninferiority trial...
January 11, 2016: JACC. Cardiovascular Interventions
Islam El-Sherbiny, Baher Nabil, Tamer Saber, Fathy Elsayed Abdelgawad
We aimed to assess the predictive value of admission HbA1c level in nondiabetic patients presented by acute STEMI, on outcome of PCI and short term outcome of adverse cardiac events. Methods. 60 nondiabetic patients were admitted to Cardiology Department, Zagazig University Hospital, with acute STMI: 27 patients with HbA1c levels of 4.5% to 6.4% (group 1), 17 patients with HbA1c levels of 6.5% to 8.5% (group 2), and 16 patients with HbA1c levels higher than 8.5% (group 3). Either invasive intervention was done at admission by (pPCI) or coronary angiography was done within month (3-28 days) from taking thrombolytic...
2015: Cardiology Research and Practice
L-H Hu, L-J Zhang, Z-T Jin, W Yang, L-N Zhang, C-Y Lu
This study aimed to investigate the effect of chronic kidney dysfunction (CKD) on the clinical characteristics of patients with acute coronary syndrome (ACS) and the degree of coronary arterial stenosis. The study enrolled 368 patients with ACS who underwent coronary angiography. Blood glucose, glycated haemoglobin (HbA1c), total cholesterol, triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), uric acid (UA), and serum creatinine were examined randomly, and the severity of coronary artery lesions was assessed using the Gensini score...
September 2015: West Indian Medical Journal
Geir Reinvik Ulimoen, Anne Pernille Ofstad, Knut Endresen, Lars Gullestad, Odd Erik Johansen, Arne Borthne
BACKGROUND: Silent coronary artery disease (CAD) is prevalent in type 2 diabetes mellitus (T2DM). Although coronary computed tomography angiography (CCTA) over recent years has emerged a useful tool for assessing and diagnosing CAD it's role and applicability for patients with T2DM is still unclarified, in particular in asymptomatic patients. We aimed to assess the role of CCTA in detecting and characterizing CAD in patients with T2DM without cardiac symptoms when compared to gold standard invasive coronary angiography (ICA)...
2015: BMC Cardiovascular Disorders
Nobutaka Ikeda, Hisao Hara, Yukio Hiroi
Increasing evidence has indicated that postprandial hyperglycemia affects coronary artery disease (CAD). The serum 1,5-anhydro-d-glucitol (1,5-AG) value is a useful clinical marker to evaluate short-term glycemic status and reflects glycemic excursions with greater sensitivity when compared with hemoglobinA1c (HbA1c), especially for patients in the postprandial state. The aim of this study was to evaluate the predictive value of 1,5-AG for CAD in patients without diabetes mellitus.This study included 729 consecutive patients who had undergone their first coronary angiography...
2015: International Heart Journal
J M Gámez, T Ripoll, V Barrios, M Anguita, M Pedreira, I Madariaga
OBJECTIVES: Cardiovascular diseases are the leading cause of death for women, especially ischaemic heart disease, which is still considered a man's disease. In Spain, there are various registries on ischaemic heart disease, although none are exclusively for women. The objectives of the SIRENA study were to describe the clinical profile of women with ischaemic heart disease treated in cardiology consultations, to estimate its prevalence of cardiovascular risk factors and understand its clinical management...
January 2016: Revista Clínica Española
Nobuo Tomizawa, Shinichi Inoh, Takeshi Nojo, Sunao Nakamura
The objective of this study was to investigate the relationship of Hemoglobin A1c (HbA1c) and plaque characteristics including high risk plaque and plaque extent. We retrospectively examined 1079 consecutive coronary computed tomography (CT) angiography scans and the HbA1c results. We divided the patients into four groups by the HbA1c status: non-diabetic, ≤6.0; borderline, 6.1-6.4; diabetic low, 6.5-7.1; diabetic high, >7.1. We determined segment involvement score >4 as extensive disease. High risk plaque was defined as two feature positive (FP) plaque which consists of positive remodeling (remodeling index >1...
March 2016: International Journal of Cardiovascular Imaging
Ping Song, Jin Xu, Yongfeng Song, Shiliang Jiang, Haitao Yuan, Xu Zhang
AIMS: This study aimed to investigate whether the change of plasma myeloperoxidase (MPO) level would be associated with the incidence of coronary artery disease (CAD) among diabetic patients. METHODS: 339 patients with type 2 diabetes mellitus (DM) underwent coronary angiography. Of them, 204 cases had CAD and were assigned to CAD group and 135 cases without CAD were assigned to non-CAD group. RESULTS: Compared to non-CAD group, CAD group had higher level of plasma MPO (p < 0...
2015: Disease Markers
Eylem Levelt, Christopher T Rodgers, William T Clarke, Masliza Mahmod, Rina Ariga, Jane M Francis, Alexander Liu, Rohan S Wijesurendra, Saira Dass, Nikant Sabharwal, Matthew D Robson, Cameron J Holloway, Oliver J Rider, Kieran Clarke, Theodoros D Karamitsos, Stefan Neubauer
AIMS: Patients with type 2 diabetes mellitus (T2DM) are known to have impaired resting myocardial energetics and impaired myocardial perfusion reserve, even in the absence of obstructive epicardial coronary artery disease (CAD). Whether or not the pre-existing energetic deficit is exacerbated by exercise, and whether the impaired myocardial perfusion causes deoxygenation and further energetic derangement during exercise stress, is uncertain. METHODS AND RESULTS: Thirty-one T2DM patients, on oral antidiabetic therapies with a mean HBA1c of 7...
September 20, 2015: European Heart Journal
Sheng-Hua Yang, Sha Li, Yan Zhang, Rui-Xia Xu, Yuan-Lin Guo, Cheng-Gang Zhu, Na-Qiong Wu, Chuan-Jue Cui, Jing Sun, Jian-Jun Li
BACKGROUND: Proprotein convertase subtilisin/kexin type 9 (PCSK9) has been demonstrated to be involved in not only lipid metabolism but also glucose homeostasis. Glycated haemoglobin (HbA1c ) is a 'gold standard' for monitoring long-term glycaemic control. However, the correlation of plasma PCSK9 levels with HbA1c remains undetermined. METHODS: We consecutively enrolled 805 subjects undergoing coronary angiography, including 176 patients with type 2 diabetes mellitus (T2DM) and 629 non-diabetic patients...
February 2016: Diabetes/metabolism Research and Reviews
Valdecira M Piveta, Fernando M A Giuffrida, Celia S Bittencourt, Carolina S V Oliveira, Pedro Saddi-Rosa, Deyse M Meira, André F Reis
INTRODUCTION: Undiagnosed hyperglycemia is common in high cardiovascular risk individuals, especially in those with coronary artery disease (CAD). There is no consensus about the optimal method for the screening of hyperglycemia in this population. SUBJECTS AND METHODS: Five hundred and fourteen Brazilian individuals undergoing coronary angiography, without previously known diabetes mellitus (DM), had their glycemic status evaluated by both fasting plasma glucose (FPG) and HbA1c, being classified in normal (N), prediabetes (PD), and DM according to American Diabetes Association criteria...
August 2015: Archives of Endocrinology and Metabolism
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