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https://www.readbyqxmd.com/read/29053718/optical-coherence-tomography-angiography-vessel-density-in-children-with-type-1-diabetes
#1
Joanna Gołębiewska, Andrzej Olechowski, Marta Wysocka-Mincewicz, Dominik Odrobina, Marta Baszyńska-Wilk, Artur Groszek, Mieczysław Szalecki, Wojciech Hautz
PURPOSE: To assess the optical coherence tomography angiography (OCTA) retinal vessel density and foveal avascular zone (FAZ) in children with type 1 diabetes (T1D) and compare potential pathologic early changes in this population to healthy age-matched controls. METHODS: This study included 130 pubescent children: 94 with T1D (188 eyes) and 36 of their age-matched control group (60 eyes). OCTA was performed using AngioVue (Avanti, Optivue). FAZ area (mm2) in superficial plexus, whole superficial capillary vessel density (wsVD), fovea superficial vessel density (fsVD), parafovea superficial vessel density (psVD), whole deep vessel density (wdVD), fovea deep vessel density (fdVD), parafovea deep vessel density (pdVD), foveal thickness (FT) (μm) and parafoveal thickness (PFT) (μm) were taken into analysis...
2017: PloS One
https://www.readbyqxmd.com/read/29018613/relationship-between-hemoglobin-glycation-index-and-extent-of-coronary-heart-disease-in-individuals-with-type-2-diabetes-mellitus-a-cross-sectional-study
#2
Po Chung Cheng, Shang Ren Hsu, Yun Chung Cheng, Yu Hsiu Liu
BACKGROUND: Individuals with type 2 diabetes (T2D) are at an increased risk of coronary heart disease (CHD). Diabetic complications have recently been associated with a measure of glucose metabolism known as the hemoglobin glycation index (HGI). Currently there is insufficient information regarding a potential link between HGI and cardiovascular disease. This study aimed to investigate the relationship between HGI and extent of CHD in individuals with T2D. METHODS: This cross-sectional study screened individuals visiting the endocrinology clinic between June 2012 and May 2016 for eligibility...
2017: PeerJ
https://www.readbyqxmd.com/read/28913755/management-and-clinical-outcome-of-stable-coronary-artery-disease-in-austria-results-from-5%C3%A2-years-of-the-clarify-registry
#3
Irene M Lang, Roza Badr-Eslam, Nicola Greenlaw, Robin Young, Philippe Gabriel Steg
BACKGROUND: The population of patients with established coronary artery disease (CAD) is growing because of an improvement in outcomes and survival from acute disease episodes. Nevertheless, these patients remain at high risk of cardiovascular events. Thus, CAD management is important in prevention of disease progression. The objective of this analysis was to describe disease management and clinical outcome of Austrian outpatients with stable CAD over 5 years by using data from the international CLARIFY registry...
September 14, 2017: Wiener Klinische Wochenschrift
https://www.readbyqxmd.com/read/28817814/cardiac-computed-tomography-angiographic-findings-as-predictors-of-late-heart-failure-in-an-asymptomatic-diabetic-cohort-an-8-year-prospective-follow-up-study
#4
David A Halon, Jubran Ayman, Ronen Rubinshtein, Barak Zafrir, Mali Azencot, Basil S Lewis
OBJECTIVES: Predictive models for heart failure (HF) in heterogeneous populations have had limited success. We examined cardiac computed tomography angiography (CTA) predictors of HF or cardiovascular death (HF-CVD) in a prospective study of asymptomatic diabetics undergoing baseline assessment by CTA. METHODS: The subjects (n = 735, aged 55-74 years, 51.2% women) had no clinical history of cardiovascular disease at study entry. Coronary artery calcium (CAC) score, CTA-defined coronary atherosclerosis, cardiac chamber volumes, and clinical data were collected and late outcome events recorded over 8...
August 18, 2017: Cardiology
https://www.readbyqxmd.com/read/28804682/effects-of-intensive-pitavastatin-therapy-on-glucose-control-in-patients-with-non-st-elevation-acute-coronary-syndrome
#5
Yan-Bo Wang, Xiang-Hua Fu, Xin-Shun Gu, Wei-Ze Fan, Yun-Fa Jiang, Guo-Zhen Hao, Qing Miao, Jie Cao, Bing Fu, Yi Li
Objective: This study aimed to investigate the effects of intensive pitavastatin therapy on glucose control in patients with non-ST elevation acute coronary syndrome (ACS). Methods: Patients who had ACS with significant stenosis on initial coronary angiography and received successful percutaneous coronary intervention (PCI) in the Second Hospital of Hebei Medical University, Shijiazhuang, China from August 2015 to January 2016 were enrolled in this study. The patients were randomized to receive pitavastatin (4 mg daily) or atorvastatin (20 mg daily)...
2017: American Journal of Cardiovascular Disease
https://www.readbyqxmd.com/read/28789650/hemoglobin-a1c-is-associated-with-severity-of-coronary-artery-stenosis-but-not-with-long-term-clinical-outcomes-in-diabetic-and-nondiabetic-patients-with-acute-myocardial-infarction-undergoing-primary-angioplasty
#6
Jianqing She, Yangyang Deng, Yue Wu, Yulong Xia, Hongbing Li, Xiao Liang, Rui Shi, Zuyi Yuan
BACKGROUND: Acute myocardial infarction (AMI) patients with type 2 diabetes mellitus are known to present with multiple vessel lesions during coronary angiography. The underlying mechanism remains elusive and there is a shortage of serum prediction markers. In this study, we investigate the relationship between admission HbA1c and severity of coronary artery stenosis and subsequent prognosis in AMI patients with or without diabetes. RESEARCH DESIGN AND METHODS: We measured admission HbA1c, and vessel scores based on the number of diseased coronary vessels with significant stenosis in 628 patients diagnosed with AMI...
August 8, 2017: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/28762929/-risk-factors-of-cardiovascular-complications-after-beating-heart-coronary-artery-bypass-grafting-in-patients-with-type-two-diabetes
#7
S Y Borodashkina, K V Protasov, V A Podkamennyi
AIM: to determine risk factors of early cardiovascular complications after beating-heart coronary artery bypass grafting (CABG) in patients with ischemic coronary disease (IHD) and type two diabetes (D2). MATERIALS AND METHODS: We included into this study 188 patients (mean age 59 years, 85.1% men) with IHD and D2 who underwent off-pump CABG. The following cardiovascular complications (CVC) registered within 7 days after surgery were analyzed: myocardial infarction (MI), stroke/transient ischemic attack (S/TIA), atrial fibrillation (AF)...
March 2017: Kardiologiia
https://www.readbyqxmd.com/read/28747945/the-impact-of-type-2-diabetes-mellitus-on-prognosis-in-patients-with-non-st-elevation-myocardial-infarction
#8
REVIEW
Katarzyna Birkner, Bartosz Hudzik, Mariusz Gąsior
Type 2 diabetes (T2D) is a recognized risk factor for acute coronary syndromes. There is currently no consensus concerning the intensification of antihyperglycemic treatment. According to the available guidelines, it seems that the goal is to achieve glycated hemoglobin (HbA1c) levels below 7% and avoid hypoglycemia. The choice of a revascularization method is influenced by many factors, such as the anatomy of the coronary arteries, severity of atherosclerosis, anatomical location of lesions, and presence of comorbidities...
June 2017: Kardiochirurgia i Torakochirurgia Polska, Polish Journal of Cardio-Thoracic Surgery
https://www.readbyqxmd.com/read/28743060/glucose-fluctuation-and-the-resultant-endothelial-injury-are-correlated-with-pancreatic-%C3%AE-cell-dysfunction-in-patients-with-coronary-artery-disease
#9
Makoto Murata, Hitoshi Adachi, Shigeru Oshima, Masahiko Kurabayashi
AIMS: We evaluated whether glucose fluctuation (GF) causes vascular endothelial injury and affects glucometabolic factors during lengthy oral glucose tolerance test (OGTT). METHODS: We enrolled consecutive 116 patients with coronary artery disease (CAD) who were performed coronary angiography and 4-h OGTT. Blood samples were collected before and 4h after glucose load to measure endothelial injury factor [von Willebrand factor (vWF) and vWF/a disintegrin-like and metalloproteinase with thrombospondin type-1 motifs 13 (ADAMTS-13) ratio]...
July 8, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28728579/circulating-sortilin-level-as-a-potential-biomarker-for-coronary-atherosclerosis-and-diabetes-mellitus
#10
Tae Jung Oh, Chang Ho Ahn, Bo-Rahm Kim, Kyoung Min Kim, Jae Hoon Moon, Soo Lim, Kyong Soo Park, Cheong Lim, HakChul Jang, Sung Hee Choi
CONTEXT: A previous genome-wide association study showed that a genetic variant of sortilin was associated with the risk of coronary artery disease (CAD). However, the role of circulating sortilin is still unknown. We investigated the potential role of plasma sortilin as a biomarker for CAD and diabetes mellitus. METHODS: We enrolled statin-naïve subjects with CAD (n = 31) who underwent coronary artery bypass surgery and control subjects (n = 116) who were free from CAD as evaluated by coronary CT angiography...
July 20, 2017: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/28687219/diabetic-macular-edema-with-and-without-subfoveal-neuroretinal-detachment-two-different-morphologic-and-functional-entities
#11
COMPARATIVE STUDY
Stela Vujosevic, Tommaso Torresin, Marianna Berton, Silvia Bini, Enrica Convento, Edoardo Midena
PURPOSE: To assess specific morphologic and functional characteristics in eyes with diabetic macular edema (DME) with subfoveal neuroretinal detachment (SND+) vs DME without SND (SND-). DESIGN: Cross-sectional, prospective, comparative case series. METHODS: Seventy-two patients (72 eyes: 22 eyes SND+ and 50 eyes SND-) with treatment-naïve, center-involving DME were evaluated. Data gathering included fundus color photographs, fluorescein angiography, spectral-domain optical coherence tomography (SD-OCT), best-corrected visual acuity (BCVA), and microperimetry...
September 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/28682149/glycosylated-haemoglobin-and-coronary-atherosclerosis-in-non-diabetic-patients-is-it-a-prognostic-factor
#12
Reza Ajudani, Mohammad Saeid Rezaee-Zavareh, Hamidreza Karimi-Sari, Mahdi Safiabadi, Fardin Dolatimehr, Mohammadreza Okhovatian, Mahdi Ramezani-Binabaj, Bahram Pishgoo
BACKGROUND: Some studies aimed to evaluate the relationship between HbA1c and coronary artery disease (CAD). However, it is well known that long-term glycometabolic disorders put the heart at risk for CAD. Considering the inconsistencies between previous studies, this study aimed to investigate the relationship between HbA1c and coronary artery atherosclerosis. METHODS: A cross-sectional study was conducted on 411 non-diabetic patients who underwent their first coronary angiography between November 2013 and December 2014 in Baqiyatallah Hospital...
October 2017: Acta Cardiologica
https://www.readbyqxmd.com/read/28663384/ct-angiography-images-of-coronary-artery-stenosis-provide-a-better-prediction-of-risk-than-traditional-risk-factors-in-asymptomatic-individuals-with-type-2-diabetes-a-long-term-study-of-clinical-outcomes
#13
Kwan Yong Lee, Byung-Hee Hwang, Tae-Hoon Kim, Chan Jun Kim, Jin-Jin Kim, Eun-Ho Choo, Ik Jun Choi, Young Choi, Ha-Wook Park, Yoon-Seok Koh, Pum-Joon Kim, Jong Min Lee, Mi-Jeong Kim, Doo Soo Jeon, Jae-Hyoung Cho, Jung Im Jung, Ki-Bae Seung, Kiyuk Chang
OBJECTIVE: We investigated the efficacy of coronary computed tomography angiography (CCTA) in predicting the long-term risks in asymptomatic patients with type 2 diabetes and compared it with traditional risk factors. RESEARCH DESIGN AND METHODS: We analyzed 933 patients with asymptomatic type 2 diabetes who underwent CCTA. Stenosis was considered obstructive (≥50%) in each coronary artery segment using CCTA. The extent and severity scores for coronary artery disease (CAD) were evaluated...
June 29, 2017: Diabetes Care
https://www.readbyqxmd.com/read/28638704/lipid-and-hyperglycemia-factors-in-first-ever-penetrating-artery-infarction-a-comparison-between-different-subtypes
#14
Shaoyang Sun, Yanqiang Wang, Yuge Wang, Xuejiao Men, Jian Bao, Xueqiang Hu, Zhengqi Lu
BACKGROUND: The pathogenesis and progression of branch atheromatous disease (BAD), which differs from lipohyalinotic degeneration (LD), remains controversial. Few studies have investigated the lipid indices and glycometabolism status factors for BAD in first-ever penetrating artery infarction (PAI). METHODS: We retrospectively examined acute stroke patients with PAI admitted within 3 days after stroke. All patients underwent diffusion weight magnetic resonance imaging (DWI) and magnetic resonance angiography (MRA) and/or computed tomography angiography (CTA)...
June 2017: Brain and Behavior
https://www.readbyqxmd.com/read/28621637/surgical-techniques-and-procedures-for-kidney-transplant-recipients-with-severe-atherosclerosis
#15
Koji Nanmoku, Yoshihiko Watarai, Shunji Narumi, Norihiko Goto, Takayuki Yamamoto, Makoto Tsujita, Takahisa Hiramitsu, Akio Katayama, Takaaki Kobayashi, Kazuharu Uchida
OBJECTIVES: Atherosclerosis is becoming a more common problem for dialysis patients. Therefore, transplant surgeons are faced with the need to develop surgical techniques and procedures for severe atherosclerosis. This study aimed to clarify the clinical features, the usefulness of examinations, and operative procedures for kidney transplant recipients with the complication of severe atherosclerosis. MATERIALS AND METHODS: Among 220 kidney transplant candidates, 13 patients (severe atherosclerosis group) were predicted complications due to arterial calcification in the bilateral iliac arterial system using a computed tomographic scan...
June 16, 2017: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/28500127/the-efficacy-of-hyperbaric-oxygen-therapy-in-the-treatment-of-central-retinal-artery-occlusion
#16
Andreia Soares, Nuno L Gomes, Luís Mendonça, Carla Ferreira
Central retinal artery occlusion (CRAO) is an ophthalmological emergency. Various treatment modalities have been tried, but none have shown to alter natural history of the disease. Hyperoxia can restore retinal oxygenation, and favourable results were obtained with hyperbaric oxygen therapy (HBOT). We report two patients with sudden visual loss due to CRAO treated with HBOT. Case 1: a 61-year-old female, presented with CRAO in her left eye(OS). She was submitted to eight sessions of HBOT(2.4atmosphere absolute (ATA))...
May 12, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28491082/altered-serum-level-of-cartilage-oligomeric-matrix-protein-and-its-association-with-coronary-calcification-in-patients-with-coronary-heart-disease
#17
Fang-Fang Wang, Lahati Ha, Hai-Yi Yu, Lin Mi, Jiang-Li Han, Wei Gao
BACKGROUND: Cartilage oligomeric matrix protein (COMP) is mainly found in the skeletal system and vascular smooth muscle cells. Recent researches showed that it had a protective function on blood vessels and could also inhibit vascular calcification. We investigated the serum COMPs in coronary heart disease (CHD) patients, and the relationship between serum COMP and the calcification of coronary artery. METHODS: A total of 233 consecutive chest pain patients who first underwent coronary angiography followed by multi-slice computed tomography (MSCT) within six months were recruited and divided into two groups according to the coronary angiography luminal diameter narrowing percentages: CHD group (diameter narrowing ≥ 50%, n = 194) and control group (diameter narrowing < 50%, n = 39)...
February 2017: Journal of Geriatric Cardiology: JGC
https://www.readbyqxmd.com/read/28403072/retinal-microvascular-alterations-related-to-diabetes-assessed-by-optical-coherence-tomography-angiography-a-cross-sectional-analysis
#18
Julien Gozlan, Pierre Ingrand, Olivier Lichtwitz, Agathe Cazet-Supervielle, Léa Benoudis, Michele Boissonnot, Samy Hadjadj, Nicolas Leveziel
Fluorescein angiography has been so far the gold-standard test to assess diabetic macular ischemia (DMI), a cause of irreversible visual impairment in diabetic patients. The aim of this study was to investigate foveal avascular zone (FAZ) and perifoveal microcirculation changes in eyes with nonproliferative diabetic retinopathy (NPDR) using optical coherence tomography angiography (OCTA), a new and noninvasive vascular imaging technique.Cross-sectional study including eyes of diabetic patients with NPDR.All patients underwent medical history, best-corrected visual acuity (BCVA) measurement, slit-lamp and fundus examination, multicolor imaging, SD-OCT, and swept-source OCT...
April 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28265463/the-cardiovascular-risk-factors-associated-with-the-plaque-pattern-on-coronary-computed-tomographic-angiography-in-subjects-for-health-check-up
#19
Dong-Hyeon Lee, Ho-Joong Youn, Hae-Ok Jung, Kiyuk Chang, Yun-Seok Choi, Jung Im Jung
BACKGROUND: Although it is known that coronary computed tomographic angiography (CCTA) offers highly negative predictive value to exclude obstructive coronary lesions, the plaque pattern on CCTA has not been fully understood. The purpose of this study was to explore the difference of the plaque patterns on CCTA and to assess the cardiovascular risks in healthy subjects. METHODS: A total of 3914 subjects (mean age: 55 ± 10 years, M : F = 2649 : 1265) who underwent CCTA for health check-up between January 2009 and December 2012 were enrolled...
2017: Clinical Hypertension
https://www.readbyqxmd.com/read/28057367/increased-pre-procedural-urinary-microalbumin-is-associated-with-a-risk-for-renal-functional-deterioration-after-coronary-computed-tomography-angiography
#20
Satoshi Isobe, Miyuki Yuba, Hiroaki Mori, Susumu Suzuki, Kimihide Sato, Hideki Ishii, Toyoaki Murohara
BACKGROUND: Urinary microalbumin is a marker for preclinical nephropathy. A percentage change in cystatin C (%CyC) of ≥10% for 24h after tests with contrast media is reportedly an independent predictor for developing contrast-induced nephropathy. We investigated the relationship between the presence of urinary microalbumin and changes in CyC after coronary computed tomography angiography (CCTA). METHODS: Three hundred and thirty-three patients with known or suspected coronary artery disease who scheduled for CCTA using a 70mL of Iopamidol were enrolled...
March 1, 2017: International Journal of Cardiology
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