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hba1c acute coronary syndrome

Shuhei Takahashi, Kazunori Shimada, Katsumi Miyauchi, Tetsuro Miyazaki, Eiryu Sai, Manabu Ogita, Shuta Tsuboi, Hiroshi Tamura, Shinya Okazaki, Tomoyuki Shiozawa, Shohei Ouchi, Tatsuro Aikawa, Tomoyasu Kadoguchi, Hamad Al Shahi, Takuma Yoshihara, Makoto Hiki, Kikuo Isoda, Hiroyuki Daida
BACKGROUND: Postprandial hyperglycemia plays an important role in the pathogenesis of coronary artery disease and cardiovascular events. Serum 1,5-anhydroglucitol (1,5-AG) levels are known to be a clinical marker of postprandial hyperglycemia. However, the impact of 1,5-AG level on cardiovascular events has not been fully investigated. METHODS: We enrolled 240 consecutive patients who had undergone first-time elective percutaneous coronary intervention (PCI) with follow-up angiography within 1 year...
October 11, 2016: Cardiovascular Diabetology
Varun Gupta, Shushil Singh, P K Maheshwari, A K Gupta, Mridul Chaturvedi
No abstract text is available yet for this article.
January 2016: Journal of the Association of Physicians of India
Debakanta Mishra, Sijoy Kurian, Namita Mohanty, Suvendu Sekhar Acharya, Suprabhat Giri
No abstract text is available yet for this article.
January 2016: Journal of the Association of Physicians of India
Thorarinn A Bjarnason, Linda B Kristinsdottir, Erna S Oskarsdottir, Steinar O Hafthorsson, Isleifur Olafsson, Sigrun H Lund, Karl Andersen
BACKGROUND: Previously undetected dysglycaemia is common among patients with acute coronary syndromes (ACSs). The aim of this study was to identify the most reliable method of diagnosing type 2 diabetes mellitus (T2DM) and prediabetes in ACS patients. METHODS: Patients admitted to the coronary care unit with ACSs and no previous history of T2DM were consecutively included in the study. Glucose metabolism was measured by glycated haemoglobin (HbA1c), fasting plasma glucose (FPG) and 2-hour plasma glucose (2hPG) with a standard oral glucose tolerance test during hospital admission, and this process was repeated 3 months later...
September 13, 2016: European Heart Journal. Acute Cardiovascular Care
Bruno Vergès
Two thirds of the patients hospitalized for an acute coronary syndrome (ACS) show disorders of glucose metabolism (diabetes, impaired fasting glucose, impaired glucose intolerance). Every patient hospitalized for an ACS whose HbA1c is equal or above 6.5% must be considered as diabetic. Each patient hospitalized for an ACS whose HbA1c is less than 6.5% should have measurement of plasma glucose fasting and after an oral glucose load between the 7th and the 28th day following the ACS in order to detect a disorder of glucose metabolism...
June 30, 2016: La Presse Médicale
J Adawiyah, A W Norasyikin, N H Mat, A S Shamsul, K Nor Azmi
INTRODUCTION: The non-thyroidal illness syndrome (NTIS) or the sick euthyroid syndrome refers to abnormal changes in circulating thyroid hormones due to systemic illnesses. Thyroid hormones are pivotal in the regulation of normal cardiac functions. However, the effects of the NTIS on the heart in acute coronary syndrome (ACS) are still unclear. METHODS: A 6-month prospective cohort study involving 85 patients admitted with ACS was carried out. TSH, FT4 and FT3 were assessed on days 1, 5 and 42...
2010: Heart Asia
Keiji Noguchi, Mamoru Sakakibara, Naoya Asakawa, Yusuke Tokuda, Kiwamu Kamiya, Takashi Yoshitani, Koji Oba, Katsumi Miyauchi, Yuji Nishizaki, Hisao Ogawa, Hiroyoshi Yokoi, Masayasu Matsumoto, Masafumi Kitakaze, Takeshi Kimura, Tetsuo Matsubara, Yuji Ikari, Kazuo Kimura, Hideki Origasa, Takaaki Isshiki, Yoshihiro Morino, Hiroyuki Daida, Hiroyuki Tsutsui
BACKGROUND: Optimal medical therapy (OMT) and the management of coronary risk factors are necessary for secondary prevention of major adverse cardiac and cerebrovascular events (MACCE) in post-acute coronary syndrome (ACS) patients. However, the effect of post-discharge patient adherence has not been investigated in Japanese patients. METHODS AND RESULTS: The Prevention of AtherothrombotiC Incidents Following Ischemic Coronary Attack (PACIFIC) registry was a multicenter, prospective observational study of 3,597 patients with ACS...
June 24, 2016: Circulation Journal: Official Journal of the Japanese Circulation Society
Beuy Joob, Viroj Wiwanitkit
No abstract text is available yet for this article.
May 2016: Indian Journal of Endocrinology and Metabolism
S S Zghebi, D T Steinke, M K Rutter, R A Emsley, D M Ashcroft
AIMS: To examine the risk of major cardiovascular events associated with second-line diabetes therapies, in patients with type 2 diabetes, after adjusting for known cardiovascular risk factors. METHODS: This was a retrospective cohort study of patients prescribed second-line regimens between 1998 and 2011 after first-line metformin. The UK Clinical Practice Research Datalink, with linked national hospitalization and mortality data, for the period up to December 2013, was used...
September 2016: Diabetes, Obesity & Metabolism
Ryo Naito, Katsumi Miyauchi, Hiroyuki Daida, Takeshi Morimoto, Takafumi Hiro, Takeshi Kimura, Yoshihisa Nakagawa, Masakazu Yamagishi, Yukio Ozaki, Masunori Matsuzaki
AIM: Diabetic patients with coronary artery disease have a high incidence of cardiovascular events, which was associated with increased coronary plaque volume. Low-density lipoprotein cholesterol (LDL-C) and blood pressure (BP) play pivotal roles in the progression of coronary plaque. Several trials have shown that intervention for a single risk factor reduced the development of coronary plaque progression. However, it remained uncertain whether total risk management for LDL-C, BP, and glycosylated Hb (HbA1c) has a beneficial effect on coronary plaque volume in diabetic patients...
August 1, 2016: Journal of Atherosclerosis and Thrombosis
A Snir, B Dabin, K Hyun, E Yamen, M Ryan, B Aliprandi-Costa, D Brieger
BACKGROUND: Guidelines for the management of acute coronary syndromes (ACS) advocate for maintaining adequate long-term glycaemic control in diabetic patients. Glycosylated haemoglobin (HbA1c) measurement is commonly used to monitor long-term glycaemic control in diabetes. AIMS: To evaluate the frequency and clinical predictors of in-hospital HbA1c measurement in diabetic patients presenting with ACS and the relationship between HbA1c assessment and mortality following discharge...
May 2016: Internal Medicine Journal
Ju-Hua Liu, Yan Chen, Michele Yuen, Zhe Zhen, Carmen Wing-Sze Chan, Karen Siu-Ling Lam, Hung-Fat Tse, Kai-Hang Yiu
BACKGROUND: Patients with type 2 diabetes mellitus (T2DM) are at high risk for cardiovascular events. The aim of the study was to assess whether global longitudinal strain (GLS) provides prognostic value in these patients. METHODS: A total of 247 T2DM patients without history of cardiovascular complications and participated in the CDATS study were prospectively enrolled. Left ventricular (LV) systolic function was assessed by LV ejection fraction and speckle tracking derived LV systolic GLS...
2016: Cardiovascular Diabetology
Deborah A Chyun, Frans J Th Wackers, Silvio E Inzucchi, Powell Jose, Curtis Weiss, Janice A Davey, Gary V Heller, Ami E Iskandrian, Lawrence H Young
OBJECTIVE: The primary aim of this secondary analysis was to determine whether cardiac autonomic neuropathy independently predicted adverse cardiac outcomes in asymptomatic individuals with type 2 diabetes. Additional aims include the determination of the correlation of standard autonomic testing measures and power spectral analysis of heart rate variability, and the association of diabetes-related and cardiac risk factors with cardiac autonomic neuropathy measures. METHODS: Cardiac autonomic neuropathy was assessed at the study entry into the Detection of Ischemia in Asymptomatic Diabetics study, using autonomic heart rate and blood pressure testing, and power spectral analysis of heart rate variability...
2015: SAGE Open Medicine
C McCune, S Maynard, B McClements, J R Lindsay
OBJECTIVE: Diabetes is highly prevalent in individuals with acute coronary syndrome (ACS). Current NICE guidelines recommend diabetes screening of hyperglycaemic patients using a fasting plasma glucose after 4 days from admission. In 2012 the World Health Organisation (WHO) approved the use of HbA1c in the diagnosis and targeted screening for type 2 diabetes. We introduced a service improvement project using HbA1c for diabetes screening in patients with no previous diagnosis of diabetes admitted with ACS regardless of glycaemic state...
October 2015: Ulster Medical Journal
Mikkel M Schoos, George D Dangas, Roxana Mehran, Ajay J Kirtane, Jennifer Yu, Claire Litherland, Peter Clemmensen, Thomas D Stuckey, Bernhard Witzenbichler, Giora Weisz, Michael J Rinaldi, Franz-Josef Neumann, D Christopher Metzger, Timothy D Henry, David A Cox, Peter L Duffy, Bruce R Brodie, Ernest L Mazzaferri, Akiko Maehara, Gregg W Stone
An increasing hemoglobin A1c (HbA1c) level portends an adverse cardiovascular prognosis; however, the association between glycemic control, platelet reactivity, and outcomes after percutaneous coronary intervention (PCI) with drug-eluting stents (DES) is unknown. We sought to investigate whether HbA1c levels are associated with high platelet reactivity (HPR) in patients loaded with clopidogrel and aspirin, thereby constituting an argument for intensified antiplatelet therapy in patients with poor glycemic control...
January 15, 2016: American Journal of Cardiology
L-H Hu, L-J Zhang, Z-T Jin, W Yang, L-N Zhang, C-Y Lu
This study aimed to investigate the effect of chronic kidney dysfunction (CKD) on the clinical characteristics of patients with acute coronary syndrome (ACS) and the degree of coronary arterial stenosis. The study enrolled 368 patients with ACS who underwent coronary angiography. Blood glucose, glycated haemoglobin (HbA1c), total cholesterol, triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), uric acid (UA), and serum creatinine were examined randomly, and the severity of coronary artery lesions was assessed using the Gensini score...
September 2015: West Indian Medical Journal
J M Gámez, T Ripoll, V Barrios, M Anguita, M Pedreira, I Madariaga
OBJECTIVES: Cardiovascular diseases are the leading cause of death for women, especially ischaemic heart disease, which is still considered a man's disease. In Spain, there are various registries on ischaemic heart disease, although none are exclusively for women. The objectives of the SIRENA study were to describe the clinical profile of women with ischaemic heart disease treated in cardiology consultations, to estimate its prevalence of cardiovascular risk factors and understand its clinical management...
January 2016: Revista Clínica Española
Donghun Shin, Jinhee Ahn, Kwang Soo Cha, Jin Sup Park, Jun-Hyok Oh, Hye-Won Lee, Ju-Yong Hong, Bo-Won Kim, Taek Jong Hong
BACKGROUND: The prognostic value of the glycemic control level, as measured using glycosylated hemoglobin (HbA1c) level, in prediabetic patients with acute coronary syndrome is still undetermined. The aim of this study was to demonstrate the influence of HbA1c level at admission on the incidence of major adverse cardiac events (MACE) in prediabetic patients with ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PCI). METHODS AND RESULTS: Using data from the Korea Working Group on Myocardial Infarction (February 2008-December 2011), this observational study included 2470 STEMI patients undergoing primary PCI who had not been diagnosed with diabetes mellitus either before or after admission (HbA1c at admission <6...
January 2016: Coronary Artery Disease
M N Islam, A A Mahmud, H Pandit, A S Bhuiyan
This was a prospective and observational study. One hundred and sixty five consecutive patients (75 diabetic and 90 were non-diabetic) admitted to coronary care unit in Rangpur Medical College and Hospital, Rangpur from December 2011 to June 2012 with the diagnosis of first attack of acute coronary syndrome were included in this study. Patients were selected considering the inclusion and exclusion criteria, Symptom time, typical or atypical chest pain, Dysponea, palpitation, cardiogenic shock, cardiac arrest, vital signs and Killip classes were regarded as presentation at admission...
July 2015: Mymensingh Medical Journal: MMJ
Kozo Okada, Kiyoshi Hibi, Masaomi Gohbara, Shunsuke Kataoka, Keiko Takano, Eiichi Akiyama, Yasushi Matsuzawa, Kenichiro Saka, Nobuhiko Maejima, Mitsuaki Endo, Noriaki Iwahashi, Kengo Tsukahara, Masami Kosuge, Toshiaki Ebina, Peter J Fitzgerald, Yasuhiro Honda, Satoshi Umemura, Kazuo Kimura
BACKGROUND: Blood glucose variability is receiving considerable attention as a new risk factor for coronary artery disease. This study aimed to investigate the association between blood glucose variability and coronary plaque tissue characteristics. METHODS: In 57 patients with acute coronary syndrome, integrated backscatter intravascular ultrasound (IB-IVUS) and gray-scale IVUS were performed before balloon dilatation or stent implantation in the culprit vessels...
2015: Cardiovascular Diabetology
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