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https://www.readbyqxmd.com/read/29149219/characterization-and-classification-of-lupus-patients-based-on-plasma-thermograms
#1
Nichola C Garbett, Guy N Brock, Jonathan B Chaires, Chongkham S Mekmaysy, Lynn DeLeeuw, Kathy L Sivils, John B Harley, Brad H Rovin, K B Kulasekera, Wael N Jarjour
OBJECTIVE: Plasma thermograms (thermal stability profiles of blood plasma) are being utilized as a new diagnostic approach for clinical assessment. In this study, we investigated the ability of plasma thermograms to classify systemic lupus erythematosus (SLE) patients versus non SLE controls using a sample of 300 SLE and 300 control subjects from the Lupus Family Registry and Repository. Additionally, we evaluated the heterogeneity of thermograms along age, sex, ethnicity, concurrent health conditions and SLE diagnostic criteria...
2017: PloS One
https://www.readbyqxmd.com/read/29148401/vitamin-d-and-systemic-lupus-erythematous-a-review-of-immunological-and-clinical-aspects
#2
REVIEW
Francesca Dall'Ara, Maurizio Cutolo, Laura Andreoli, Angela Tincani, Sabrina Paolino
OBJECTIVES: To review the relationships between vitamin D status and systemic lupus erythematosus (SLE) concerning immunological, clinical aspects and possible effects of supplementation in disease modulation. METHODS: The literature was reviewed up to January 2017 for studies regarding the epidemiology, pathogenesis, immunological aspects, clinical implications and supplementation strategies. The focus was mainly on studies with implications on every day clinical practice...
November 14, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/29142038/more-consistent-antimalarial-intake-in-first-5-years-of-disease-is-associated-with-better-prognosis-in-patients-with-systemic-lupus-erythematosus
#3
Rattapol Pakchotanon, Dafna D Gladman, Jiandong Su, Murray B Urowitz
OBJECTIVE: To examine whether more consistent use of antimalarial agents (AM) leads to better results in systemic lupus erythematosus (SLE). METHODS: From a longitudinal cohort study, we identified inception patients with a minimum of 5 years of followup. They were divided into 3 groups: patients who took AM > 60% of the time (group A), those who took AM < 60% of the time (group B), and those who did not receive AM (group C) during the first 5 years of followup...
November 15, 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/29142034/cumulative-burden-of-glucocorticoid-related-adverse-events-in-patients-with-systemic-lupus-erythematosus-findings-from-a-12-year-longitudinal-study
#4
Hung-Lin Chen, Li-Jiuan Shen, Ping-Ning Hsu, Chieh-Yu Shen, Susan A Hall, Fei-Yuan Hsiao
OBJECTIVE: The aim of this population-based study is to examine the adverse events (AE) associated with longitudinal systemic glucocorticoid (GC) use among an ethnic Chinese systemic lupus erythematosus (SLE) cohort. METHODS: Our study subjects were patients with newly diagnosed SLE aged 18 and older who received at least 1 prescription of systemic GC between 2001 and 2012 from Taiwan's National Health Insurance Research Database (NHIRD). The earliest prescription date of systemic GC for each subject was defined as the index date...
November 15, 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/29141377/-the-clinical-significance-of-anti-ubiquitin-c-terminal-hydrolase-l1-autoantibodies-in-the-diagnosis-of-neuropsychiatric-systemic-lupus-erythematosus
#5
Y Meng, H Sun, J J Xu, R Li, Y Wang
Objective: To analyze the clinical significance of anti- ubiquitin C-terminal hydrolase L1(UCHL-1)autoantibodies in neuropsychiatric systemic lupus erythematosus (NPSLE). Methods: Autoantibodies in cerebrospinal fluid specimen of 56 inpatients were detected by using indirect enzyme-linked immunosorbent assay (ELISA) and the fullmedical history and clinical manifestations were analyzed retrospectively. Results: The levels of anti-UCHL-1 autoantibodies in NPSLE group were significant higher than that in other controls (P<0...
November 14, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29137108/tuberculosis-presenting-as-isolated-bronchonodal-fistula-in-a-patient-with-systemic-lupus-erythematosus-case-report
#6
Kyungsoo Bae, Kyung Nyeo Jeon, Ho Cheol Kim, Young Sun Suh, Gi Dong Lee, Ju-Young Kim, Dae Hyun Song
RATIONALE: Lymph node is a preferred site for extrapulmonary tuberculosis (TB). In the thorax, mediastinal tuberculous lymph nodes can erode adjacent structures such as heart, aorta, and esophagus, forming fistula, and causing fatal consequences. However, tuberculous bronchonodal fistula as a complication of lymph node TB in adults is rarely known in terms of imaging or clinical findings. Here, a case of isolated tuberculous bronchonodal fistula appearing as the first presentation of TB in a 74-year-old male with systemic lupus erythematosus (SLE) is reported...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29136338/the-perspectives-of-medical-specialists-from-different-disciplines-on-the-management-of-systemic-lupus-erythematosus-an-interview-study
#7
David J Tunnicliffe, Davinder Singh-Grewal, Jonathan C Craig, Shilpanjali Jesudason, Peter Tugwell, Ming-Wei Lin, Sean G O'Neill, Daniel Sumpton, Allison Tong
OBJECTIVES: Systemic lupus erythematosus (SLE) is a complex autoimmune disease that can affect multiple organ systems, with specialists from many disciplines often involved, which may lead to inconsistent care. We aimed to describe the attitudes and perspectives of specialists from different medical disciplines on the management of people with SLE. METHODS: Face-to-face, semi-structured interviews were conducted with rheumatologists (n=16), nephrologists (n=16), and immunologists (n=11) providing care to adults with SLE from 19 centers across Australia in 2015...
November 14, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/29136041/profiling-analysis-of-circulating-microrna-in-peripheral-blood-of-patients-with-class-iv-lupus-nephritis
#8
Elkin Navarro-Quiroz, Lisandro Pacheco-Lugo, Roberto Navarro-Quiroz, Hernan Lorenzi, Pierine España-Puccini, Yirys Díaz-Olmos, Lisneth Almendrales, Valeria Olave, Henry Gonzalez-Torres, Anderson Diaz-Perez, Alex Dominguez, Antonio Iglesias, Raul García, Gustavo Aroca-Martinez
Renal involvement in Systemic Lupus Erythematous (SLE) patients is one of the leading causes of morbidity and a significant contributor to mortality. It's estimated that nearly 50% of SLE individuals develop kidney disease in the first year of the diagnosis. Class IV lupus nephritis (LN-IV) is the class of lupus nephritis most common in Colombian patients with SLE. Altered miRNAs expression levels have been reported in human autoimmune diseases including lupus. Variations in the expression pattern of peripheral blood circulating miRNAs specific for this class of lupus nephritis could be correlated with the pathophysiological status of this group of individuals...
2017: PloS One
https://www.readbyqxmd.com/read/29135750/student-and-educator-experiences-of-maternal-child-simulation-based-learning-a-systematic-review-of-qualitative-evidence
#9
Karen MacKinnon, Lenora Marcellus, Julie Rivers, Carol Gordon, Maureen Ryan, Diane Butcher
BACKGROUND: Although maternal-child care is a pillar of primary health care, there is a global shortage of maternal-child health care providers. Nurse educators experience difficulties providing undergraduate students with maternal-child learning experiences for a number of reasons. Simulation has the potential to complement learning in clinical and classroom settings. Although systematic reviews of simulation are available, no systematic reviews of qualitative evidence related to maternal-child simulation-based learning (SBL) for undergraduate nursing students and/or educators have been located...
November 2017: JBI Database of Systematic Reviews and Implementation Reports
https://www.readbyqxmd.com/read/29130759/preeclampsia-in-pregnancies-complicated-by-sle-nephritis-prophylactic-treatment-with-multidisciplinary-approach-are-important-keys-to-prevent-adverse-obstetrics-outcomes
#10
Federico Mecacci, Serena Simeone, Calogero Lino Cirami, Mauro Cozzolino, Caterina Serena, Marianna Pina Rambaldi, Pamela Gallo, Lorenzo Emmi, Daniele Cammelli, Giorgio Mello, Marco Matucci Cerinic
INTRODUCTION: Systemic lupus erythematosus (SLE) commonly affects women of childbearing age. Hypertension, antiphospholipid syndrome and lupus nephritis are risk factors for adverse maternal/fetal outcome. The aim of this retrospective cohort study is to compare pregnancy outcomes in patients with and without SLE nephritis, using a multidisciplinary approach and a broad prophylaxis protocol. MATERIALS AND METHODS: Data were collected from 86 pregnancies complicated by SLE...
November 12, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29130124/systemic-autoimmune-diseases-complicated-with-hydrocephalus-pathogenesis-and-management
#11
REVIEW
Hexiang Yin, Junji Wei, Li Wang, Liying Cui, Renzhi Wang
Systemic autoimmune diseases (SAIDs) represent a group of syndromes involving at least two organ systems. Classical SAIDs include connective tissue diseases, vasculitis, and granulomatous diseases, many of which involve the nervous system and result in different neurological manifestations. Hydrocephalus can be a rare but lethal complication of various SAIDs, including systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), sarcoidosis, and primary vasculitis. However, the pathogenesis of SAIDs complicated with different types of hydrocephalus is varied and difficult to determine using the existing published data, and various manifestations and expressive forms of the conditions bring a substantial challenge to a timely clinical diagnosis and treatment...
November 12, 2017: Neurosurgical Review
https://www.readbyqxmd.com/read/29126432/failure-to-achieve-lupus-low-disease-activity-state-lldas-six-months-after-diagnosis-is-associated-with-early-damage-accrual-in-caucasian-patients%C3%A2-with-systemic-lupus-erythematosus
#12
Matteo Piga, Alberto Floris, Giulia Cappellazzo, Elisabetta Chessa, Mattia Congia, Alessandro Mathieu, Alberto Cauli
BACKGROUND: The aim was to assess the attainability and outcome of the lupus low disease activity state (LLDAS) in the early stages of systemic lupus erythematosus (SLE). METHODS: LLDAS prevalence was evaluated at 6 (T1) and 18 (T2) months after diagnosis and treatment initiation (T0) in a monocentric cohort of 107 (median disease duration 9.7 months) prospectively followed Caucasian patients with SLE. Reasons for failure to achieve LLDAS were also investigated...
November 10, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/29123443/plasma-atherogenic-index-is-an-independent-indicator-of-subclinical-atherosclerosis-in-systemic-lupus-erythematosus
#13
Ali Ugur Uslu, Adem Kucuk, Abdullah Icli, Erkan Cure, Davut Sakiz, Sevket Arslan, Rabia Aydogan Baykara
Objective: Systemic lupus erythematosus (SLE) is characterized by chronic inflammation. Plasma atherogenic index (PAI) is a valuable marker for the cardiovascular disease and cardiac risk. The aim of this study was to evaluate the role and clinical use of PAI in atherosclerosis and the cardiac risk in SLE patients. Materials and Methods: We included 56 female SLE patients who were selected according to the American College of Rheumatology (1997) diagnosis criteria...
October 2017: Eurasian Journal of Medicine
https://www.readbyqxmd.com/read/29120258/evaluation-of-the-alternative-classification-criteria-of-systemic-lupus-erythematosus-established-by-systemic-lupus-international-collaborating-clinics-slicc
#14
Kenji Oku, Tatsuya Atsumi, Yuji Akiyama, Hirofumi Amano, Naoto Azuma, Toshiyuki Bohgaki, Yu Funakubo Asanuma, Tetsuya Horita, Tadashi Hosoya, Kunihiro Ichinose, Masaru Kato, Yasuhiro Katsumata, Yasushi Kawaguchi, Atsushi Kawakami, Tomohiro Koga, Hitoshi Kohsaka, Yuya Kondo, Kanae Kubo, Masataka Kuwana, Akio Mimori, Tsuneyo Mimori, Toshihide Mimura, Kosaku Murakami, Kazuhisa Nakano, Shingo Nakayamada, Hiroshi Ogishima, Kazumasa Ohmura, Kazuyoshi Saito, Hajime Sano, Mihoko Shibuya, Yuko Takahashi, Yoshinari Takasaki, Tsutomu Takeuchi, Naoto Tamura, Yoshiya Tanaka, Hiroto Tsuboi, Shinichiro Tsunoda, Naoichiro Yukawa, Noriyuki Yamakawa, Kazuhiko Yamamoto, Takayuki Sumida
OBJECTIVE: To evaluate the performance of the 2012 Systemic Lupus International Collaborating Clinics criteria (SLICC-12) on classifying systemic lupus erythematosus (SLE) in an uncontrolled multi-centered study with real-life scenario of the patients in Japan. METHODS: This study comprised 495 patients with SLE or non-SLE rheumatic diseases and allied conditions from 12 institutes in Japan. Chart review of each patient was performed by the 27 expert rheumatologists and diagnosis of 487 cases reached to the consensus...
November 9, 2017: Modern Rheumatology
https://www.readbyqxmd.com/read/29118999/associates-and-predictors-of-pleurisy-or-pericarditis-in-sle
#15
Seungwon Ryu, Wei Fu, Michelle A Petri
Background/Purpose: Serositis is one of both ACR and SLICC classification criteria for systemic lupus erythematosus (SLE) and a common type of extra renal flare. However, little is known about clinical or immunological associations of pleurisy or pericarditis. The aim of this study is to analyze associates and predictors of pleurisy versus pericarditis in Caucasians and African Americans with SLE. Methods: 2,390 SLE patients in the Hopkins Lupus Cohort were analyzed for demographic, clinical and serologic associates of pleurisy or pericarditis, defined using the SELENA revision of the SLE Disease Activity Index (SLEDAI)...
2017: Lupus Science & Medicine
https://www.readbyqxmd.com/read/29115062/monogenic-interferonopathies-phenotypic-and-genotypic-findings-of-candle-syndrome-and-its-overlap-with-c1q-deficient-sle
#16
Sulaiman M Al-Mayouf, Alhanouf AlSaleem, Nora AlMutairi, Abdullah AlSonbul, Tariq Alzaid, Anas M Alazami, Hamoud Al-Mousa
OBJECTIVE: To report the clinical and genetic features of the first cases of chronic atypical neutrophilic dermatosis with lipodystrophy and elevated temperature (CANDLE) syndrome in an Arab population and to compare them with patients of C1q deficient systemic lupus erythematosus (SLE). MATERIALS AND METHODS: This is a retrospective case series of patients with CANDLE syndrome and C1q deficient SLE seen at a single tertiary hospital. Medical records were reviewed for demographic data, clinical and laboratory features, histopathology and imaging findings, and response to therapeutic intervention...
November 8, 2017: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/29113694/-lupus-erythematosus-treatment-with-belimumab-in-daily-practice-retrospective-study-of-15-patients
#17
E Garval, J-L Pennaforte, R Jaussaud, A Servettaz, P Bernard, Z Reguiai
BACKGROUND: Belimumab (an anti-BLyS monoclonal antibody) was recently approved for the treatment of systemic lupus erythematosus (SLE). The aim of the study was to describe efficacy and safety of the drug as well as its impact on serologic parameters and the role of long-term systemic sparing of treatment in clinical practice in LE. PATIENTS AND METHODS: We conducted a retrospective study at Reims University Hospital between 2012 and 2016 including consecutive patients with LE treated with belimumab...
November 4, 2017: Annales de Dermatologie et de Vénéréologie
https://www.readbyqxmd.com/read/29108828/can-we-manage-lupus-nephritis-without-chronic-corticosteroids-administration
#18
REVIEW
Liz Lightstone, Andrea Doria, Hannah Wilson, Frank L Ward, Maddalena Larosa, Joanne M Bargman
The outcome of lupus nephritis (LN) has changed since the introduction of glucocorticoids (GCs), which dramatically reduced the mortality related to one of the most severe complications of systemic lupus erythematosus (SLE). Since the 1950's, other immunosuppressants, including biologic drugs (i.e. rituximab) have aided in maintaining remission, preserving kidney function, but not preventing treatment-related toxicity. GCs still remain the cornerstone in the treatment of SLE, including LN, and they are widely used in clinical practice...
November 3, 2017: Autoimmunity Reviews
https://www.readbyqxmd.com/read/29108826/physical-activity-and-autoimmune-diseases-get-moving-and-manage-the-disease
#19
REVIEW
Kassem Sharif, Abdulla Watad, Nicola Luigi Bragazzi, Micheal Lichtbroun, Howard Amital, Yehuda Shoenfeld
Physical activity, by definition, is any skeletal muscle body movement that results in energy expenditure. In the last few decades, a plethora of scientific evidences have accumulated and confirmed the beneficial role of physical activity as a modifiable risk factor for a wide variety of chronic diseases including cardiovascular diseases (CVDs), diabetes mellitus and cancer, among others. Autoimmune diseases are a heterogeneous group of chronic diseases, which occur secondary to loss of self-antigen tolerance...
November 3, 2017: Autoimmunity Reviews
https://www.readbyqxmd.com/read/29108825/targeting-interferons-and-their-pathways-in-systemic-lupus-erythematosus
#20
REVIEW
François Chasset, Laurent Arnaud
Significant advances in the understanding of the molecular basis of innate immunity have led to the identification of interferons (IFNs), particularly IFN-α, as central mediators in the pathogenesis of Systemic Lupus Erythematosus. Therefore, targeting of IFNs and of their downstream pathways has emerged as important developments for novel drug research in SLE. Based on this, several specific interferon blocking strategies using anti-IFN-α antibodies, anti-type I interferon receptor antibodies, Interferon-α-kinoid, or anti-IFN-γ antibodies have all been assessed in recent clinical trials...
November 4, 2017: Autoimmunity Reviews
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