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CDK guidelines

Tahir Ali Chohan, Jiong-Jiong Chen, Hai-Yan Qian, You-Lu Pan, Jian-Zhong Chen
CDK2 is a promising target for the development of anti-cancer agents. It is not an easy task to design CDK2-selective inhibitors which do not exhibit activity for other CDK family members, particularly CDK4, due to a high degree of structural homology among CDK family members. In this study, 4-substituted N-phenylpyrimidin-2-amine derivatives as CDK2 inhibitors were examined to understand the selectivity mechanism against CDK4 using a combined approach of 3D-QSAR, molecular docking, MESP, MD simulations, and binding free energy calculations...
April 2016: Molecular BioSystems
Tahir Ali Chohan, Hai-Yan Qian, You-Lu Pan, Jian-Zhong Chen
Cyclin dependent kinase 2 (CDK2) was regarded as a potentially therapeutic target for cancer therapy. Since the CDK family includes couples of high homology members, designing CDK2-selective inhibitors would provide valuable opportunities for the development of anticancer drugs with optimal efficacy. In this study, three thiazo-5-yl-pyrimidines as CDK2 inhibitors with different selectivity over cyclin dependent kinase 7 (CDK7) were examined to study the selectivity mechanism using a combined approach of computational techniques of flexible docking, EasyMIFs, molecular electrostatic potential (MESP), natural bond orbital (NBO), molecular dynamics (MD) simulations, and binding free energy calculations...
January 2016: Molecular BioSystems
Jaswant Kumar, Ish Kumar Dhammi, Anil K Jain
Neglected bilateral congenital dislocation of knee is unusual. A 12 year old boy presented with inability to walk due to buckling of the knee. The symptoms were present since the child learnt walking. He preferred not to walk. Bilateral supracondylar femoral osteotomy was done at the age of 6 years. Patient had a fixed flexion deformity of both knees, 30° in the right (range of flexion from 30° to 45°) and 45° fixed flexion deformity in left knee respectively (range of flexion from 45° to 65°) when presented to us...
January 2014: Indian Journal of Orthopaedics
Stéphanie Castagnet, Hélène Blasco, Patrick Vourc'h, Isabelle Benz-De-Bretagne, Charlotte Veyrat-Durebex, Christelle Barbet, Azmi Alnajjar, Bénédicte Ribourtout, Matthias Buchler, Jean-Michel Halimi, Christian R Andres
Estimated glomerular filtration rate (eGFR) methods are not sufficiently reliable in renal transplant recipients (RTR) and should be replaced by iohexol plasma clearance measurement. However, this method has poor availability in health centers. The aim of our study was to develop a high-performance liquid chromatography (HPLC) method for plasma iohexol measurement in routine practice and to evaluate its plasma clearance as a reference of GFR. We developed an HPLC method using UV detection. We evaluated sample storage conditions to provide recommendations for routine practice...
September 2012: Journal of Clinical Laboratory Analysis
M Paradela de la Morena, M De La Torre Bravos, R Fernández Prado, M Delgado Roel, J A García Salcedo, E Fieira Costa, D González Rivas, J M Borro Maté
OBJECTIVE: The purpose of this study was to determinate the incidence of risk factors and therapeutic strategies for chronic kidney disease (CKD) among our lung transplant recipients. We also analyzed the association with 1-, 2-, and 5-years mortality after lung transplantation. PATIENTS AND METHODS: This descriptive, retrospective study of 161 patients undergoing lung transplantations between June 1999 and December 2008 assessed the incidence and severity of CKD, following the updated guidelines of the National Kidney Foundation...
October 2010: Transplantation Proceedings
Bénédicte Menn, Stéphane Bach, Teri L Blevins, Mark Campbell, Laurent Meijer, Serge Timsit
BACKGROUND: Although quite challenging, neuroprotective therapies in ischemic stroke remain an interesting strategy to counter mechanisms of ischemic injury and reduce brain tissue damage. Among potential neuroprotective drug, cyclin-dependent kinases (CDK) inhibitors represent interesting therapeutic candidates. Increasing evidence indisputably links cell cycle CDKs and CDK5 to the pathogenesis of stroke. Although recent studies have demonstrated promising neuroprotective efficacies of pharmacological CDK inhibitors in related animal models, none of them were however clinically relevant to human treatment...
August 12, 2010: PloS One
Z P Balsara, M H Hussein, P J Winch, R Gipson, M Santosham, G L Darmstadt
OBJECTIVE: A major factor contributing to neonatal and maternal infections is unhygienic delivery practices. This study explores the impact of clean delivery kit (CDK) use on clean delivery practices during home and facility deliveries. DESIGN: Kits were distributed from primary care facilities and mothers and birth attendants received training on kit importance and use. The study was designed as a cross-sectional cohort study. Raedat (community health workers) visited 349 women during the postpartum period to administer a structured questionnaire...
October 2009: Journal of Perinatology: Official Journal of the California Perinatal Association
Jon J Snyder, Allan J Collins
BACKGROUND/AIMS: National Kidney Foundation Kidney Disease Outcomes Quality Initiative (KDOQI) guidelines aim to slow chronic kidney disease (CKD) progression and reduce morbidity and mortality. This study aimed to assess current CKD population health and adherence to recommendations in National Health and Nutrition Examination Survey 1999-2004 participants aged >or=20 years (n = 14,213). METHODS: We assessed hypertension and dyslipidemia management and diabetes control, stratified by CKD status and prior history of cardiovascular disease (CVD), to ascertain awareness, treatment, and control...
2009: American Journal of Nephrology
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