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https://www.readbyqxmd.com/read/27595122/drug-induced-hypothyroidism-during-anti-tuberculosis-treatment-of-multidrug-resistant-tuberculosis-notes-from-the-field
#1
Somashekar Munivenkatappa, Singarajipura Anil, Balaji Naik, Tyson Volkmann, Karuna D Sagili, Jayachamarajapura S Akshatha, Shashidhar Buggi, Manchenahalli A Sharada, Sudhendra Kulkarni, Vineet K Chadha, Patrick K Moonan
We followed 188 euthyroidic persons undergoing treatment for multidrug resistant tuberculosis (MDR-TB) in the state of Karnataka, India to determine the incidence of hypothyroidism during anti-tuberculosis treatment. Overall, among MDR-TB patients with valid thyroid stimulating hormone (TSH) values, about 23% developed hypothyroidism (TSH value ≥10 mIU/ml) during anti-tuberculosis treatment; the majority (74%) occurring after 3 months of treatment. Among 133 patients who received a regimen that contained ethionamide, 42 (32%) developed hypothyroidism...
September 2016: Journal of Tuberculosis Research
https://www.readbyqxmd.com/read/27476635/para-dichlorobenzene-exposure-is-associated-with-thyroid-dysfunction-in-us-adolescents
#2
Yudan Wei, Jianmin Zhu
OBJECTIVE: To examine the association between exposure to para-dichlorobenzene, measured as urinary concentrations of 2,5-dichlorophenol (2,5-DCP), and thyroid function in US adolescents. STUDY DESIGN: A nationally representative subsample of 618 adolescents aged 12-19 years in the 2007-2008 and 2011-2012 National Health and Nutrition Examination Survey was analyzed for the association of urinary 2,5-DCP with serum thyroid function measures using multivariate logistic and general linear regression models...
October 2016: Journal of Pediatrics
https://www.readbyqxmd.com/read/26591370/-effect-of-jiakangning-capsule-on-thyroid-function-and-akt-mtor-signal-pathway-of-graves-disease-mice-an-experimental-study
#3
Qing-mu Li, Jung-ping Wei, Min Li, Shu-hua Meng
OBJECTIVE: To observe the improvement of thyroid function and changes of Akt, p-Akt, mammalian target of rapamycin (mTOR), and para-mTOR (p-mTOR) expression in Graves' disease (GD) mice after intervened by Jiakangning Capsule (JC), and to explore possible mechanism for JC in treating GD. METHODS: GD model was established by immunizing female BALB/c mice with thyroid stimulating hormone receptor A subunit (Ad-TSHRα-289). Totally 70 successfully modeled mice were divided into the model group (n =20), the JC intervened group (n =25), the Methimazole Tablet intervened group (n =25) according to random digit table...
September 2015: Chinese Journal of Integrated Traditional and Western Medicine
https://www.readbyqxmd.com/read/26306673/urinary-iodine-excretion-and-thyroid-function-status-in-school-age-children-of-hilly-and-plain-regions-of-eastern-nepal
#4
Prem Raj Shakya, Basanta Gelal, Binod Kumar Lal Das, Madhab Lamsal, Paras Kumar Pokharel, Ashwini Kumar Nepal, David A Brodie, Gauri Shankar Sah, Nirmal Baral
BACKGROUND: Iodine deficiency is a major public health problem in many developing countries including Nepal. The present study was designed to investigate the urinary iodine excretion (UIE), thyroid function status and household salt iodine content (SIC) in school-aged children (SAC) and to establish the relationships between these factors. METHODS: A community-based cross sectional study was conducted in selected schools of two districts, Tehrathum and Morang, lying in the hill and plain region of eastern Nepal respectively...
2015: BMC Research Notes
https://www.readbyqxmd.com/read/26177318/c-cells-and-their-associated-lesions-and-conditions-a-pathologists-perspective
#5
REVIEW
Zubair W Baloch, Virginia A LiVolsi
This paper updates the histopathology and cytopathology of thyroid tumors and proliferations derived from the para-follicular or C cells. Beginning with an historical over view, including the recognition of medullary thyroid carcinoma as a distinct histologic entity, its relationship to the hormone, calcitonin, (which was discovered in the same decade) and to thyroid C cells, medullary carcinoma and its variants are reviewed. The molecular biology of the tumors and the associated mutations in the tumors (somatic mutations) are discussed...
2015: Türk Patoloji Dergisi
https://www.readbyqxmd.com/read/26092582/immunoglobulin-g4-related-diseases-in-the-head-and-neck-a-systematic-review
#6
REVIEW
Graeme B Mulholland, Caroline C Jeffery, Paras Satija, David W J Côté
BACKGROUND: Immunoglobulin G4 related disease (IgG4-RD) is a poorly understood chronic inflammatory disorder affecting the middle-aged and elderly that can present to the otolaryngologist. We aim to summarize the current literature regarding the manifestations and management of IgG4-RD in the head and neck. METHODS: Pubmed and EMBASE were searched using the term relevant search algorithm utilizing keywords such as: IgG4 related disease, head and neck, orbit, salivary glands, sialadenitis, Kuttner, angiocentric eosinophilic fibrosis, submandibular, lacrimal, thyroid, dacryoadenitis, nasal, sinus, and Mikulicz's...
2015: Journal of Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/25512056/long-term-efficacy-of-current-thyroid-prophylaxis-and-future-perspectives-on-thyroid-protection-during-131i-metaiodobenzylguanidine-treatment-in-children-with-neuroblastoma
#7
S C Clement, R R van Rijn, B L F van Eck-Smit, A S P van Trotsenburg, H N Caron, G A M Tytgat, H M van Santen
PURPOSE: Treatment with (131)I-MIBG is associated with significant thyroid damage. This study was undertaken to investigate the long-term efficacy of current thyroid prophylaxis, to explore the relationship between thyroid dysfunction and thyroid volume after exposure to (131)I-MIBG and to evaluate the possible negative effects of (131)I(-) on the parathyroid glands. METHODS: Of 81 long-term surviving patients with neuroblastoma treated with (131)I-MIBG during the period 1999-2012, 24 were finally evaluated...
April 2015: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/25138556/endocrine-actions-of-pesticides-measured-in-the-flemish-environment-and-health-studies-flehs-i-and-ii
#8
K Croes, E Den Hond, L Bruckers, E Govarts, G Schoeters, A Covaci, I Loots, B Morrens, V Nelen, I Sioen, N Van Larebeke, W Baeyens
Within the Flemish Environment and Health studies (FLEHS I, 2002-2006, and FLEHS II, 2007-2012), pesticide exposure, hormone levels and degree of sexual maturation were measured in 14-15-year-old adolescents residing in Flanders (Belgium). In FLEHS II, geometric mean concentrations (with 95 % confidence interval (CI)) of 307 (277-341) and 36.5 ng L(-1) (34.0-39.2) were found for p,p'-dichlorophenyldichloroethylene (p,p'-DDE) and hexachlorobenzene (HCB). These values were respectively 26 and 60 % lower than levels in FLEHS I, 5 years earlier...
October 2015: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/24434398/adaptation-and-implementation-of-the-kidney-disease-improving-global-outcomes-kdigo-guidelines-for-evaluation-and-management-of-mineral-and-bone-disorders-in-chronic-kidney-disease-for-practice-in-the-middle-east-countries
#9
REVIEW
Mona Al Rukhaimi, Ali Al Sahow, Yousef Boobes, David Goldsmith, Jose Khabouth, Tarek El Baz, Hisham Mahmoud, Mohammad Reza Ganji, Faissal A M Shaheen
This review presents the views of an expert group of nephrologists from the Middle East along with an international expert on adaptation and implementation of the 2009 Kidney Disease: Improving Global Outcomes (KDIGO) guidelines for evaluation and manage-ment of mineral and bone disorders in chronic kidney disease (CKD-MBD) for practice in the Middle East countries. The members of the panel examined the KDIGO guidelines and formulated recommendations that can be implemented practically for the management of CKD-MBD in the Middle East...
January 2014: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/23954912/neural-correlates-of-free-t3-alteration-after-catecholamine-depletion-in-subjects-with-remitted-major-depressive-disorder-and-in-controls
#10
RANDOMIZED CONTROLLED TRIAL
Philipp Homan, Wayne C Drevets, Gregor Hasler
RATIONALE: Thyroid hormones and their interactions with catecholamines play a potentially important role in alterations of mood and cognition. OBJECTIVES: This study aimed to examine the neurobiological effects of catecholamine depletion on thyroid hormones by measuring endocrine and cerebral metabolic function in unmedicated subjects with remitted major depressive disorder (RMDD) and in healthy controls. METHODS: This was a randomized, placebo-controlled, and double-blind crossover trial that included 15 unmedicated RMDD subjects and 13 healthy control subjects...
January 2014: Psychopharmacology
https://www.readbyqxmd.com/read/23585555/relationship-between-serum-tsh-levels-and-intrarenal-hemodynamic-parameters-in-euthyroid-subjects
#11
Akihiro Tsuda, Masaaki Inaba, Mitsuru Ichii, Akinobu Ochi, Yoshiteru Ohno, Shinya Nakatani, Shinsuke Yamada, Katsuhito Mori, Hideki Tahara, Eiji Ishimura
OBJECTIVE: Low thyroid function may be associated with a reduced glomerular filtration rate (GFR) calculated on the basis of creatinine metabolism. Thyroid hormone directly affects serum creatinine in muscle and low thyroid function might exert a similar direct effect in the kidney. The goal of the study was to evaluate this possibility by assessment of the inulin-based GFR and to examine the mechanism underlying the reduction of GFR. PATIENTS AND METHODS: Renal and glomerular hemodynamics were assessed by simultaneous measurements of plasma clearance of para-aminohippurate (CPAH) and inulin (Cin) in 26 patients with serum creatinine <1...
July 2013: European Journal of Endocrinology
https://www.readbyqxmd.com/read/21943844/abnormal-thyroid-function-tests-in-children-on-ethionamide-treatment
#12
S Thee, E W Zöllner, M Willemse, A C Hesseling, K Magdorf, H S Schaaf
Ethionamide (ETH) treatment may cause hypothyroidism. Clinical data, serum thyroid stimulating hormone (TSH) and free thyroxine (fT4) levels were retrospectively assessed in 137 children receiving anti-tuberculosis treatment including ETH. Abnormal thyroid function tests (TFTs) were recorded in 79 (58%) children: elevated serum TSH and suppressed fT4 (n = 30), isolated elevated serum TSH (n = 20), isolated low serum fT4 (n = 28) and isolated low TSH (n = 1). The risk for biochemical hypothyroidism was higher for children on regimens including para-aminosalicylic acid and in human immunodeficiency virus infected children...
September 2011: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/21313880/a-review-on-hyperthyroidism-thyrotoxicosis-under-surveillance
#13
REVIEW
Azad Reza Mansourian
Thyrotoxicosis exhibit collective clinical manifestation, caused by excessive serum thyroid hormones particularity thyroxin. The clinical signs and symptoms included general alteration of metabolic process leading to weight loss fatigue and weakness and some specific disorders such as cardiovascular, neuromuscular reproductive gastrointestinal dermatological and bone disorders. The diagnosis of thyrotoxicosis relay on the thyroid function test carried out by the laboratory serum measurement of thyroxin, triiodothyronine and thyroid stimulating hormones accompanied by other para-medical examinations suggested by clinicians and endociologicst...
November 15, 2010: Pakistan Journal of Biological Sciences: PJBS
https://www.readbyqxmd.com/read/21291240/species-specific-differences-and-structure-activity-relationships-in-the-debromination-of-pbde-congeners-in-three-fish-species
#14
Simon C Roberts, Pamela D Noyes, Evan P Gallagher, Heather M Stapleton
Previous studies have suggested that there may be species-specific differences in the metabolism of polybrominated diphenyl ethers (PBDEs) among different fish species. In this study, we investigated the in vitro hepatic metabolism of eleven individual PBDE congeners (tri- through decaBDEs) in three different fish species: rainbow trout (Oncorhynchus mykiss), common carp (Cyprinus carpio), and Chinook salmon (O. tschwatcha). In addition, we evaluated the influence of PBDE structural characteristics (i.e., bromine substitution patterns) on metabolism...
March 1, 2011: Environmental Science & Technology
https://www.readbyqxmd.com/read/20857061/mutations-in-the-gene-encoding-paired-box-domain-pax8-are-not-a-frequent-cause-of-congenital-hypothyroidism-ch-in-iranian-patients-with-thyroid-dysgenesis
#15
Frouzandeh Mahjoubi, Mona Malek Mohammadi, Maryam Montazeri, Masoud Aminii, Mahin Hashemipour
OBJECTIVE: Congenital hypothyroidism (CH) may be caused by defects in the thyroid or in one of the stages in the synthesis of thyroid hormones. Thyroid dysgenesis may be associated with mutation in the paired box transcription factor 8 (PAX8) gene. We attempted to screen PAX8 gene mutation in 50 CH patients with thyroid dysgenesis. SUBJECTS AND METHODS: The patients were classified in two groups as agenesis and ectopic based on biochemical and para clinical tests...
August 2010: Arquivos Brasileiros de Endocrinologia e Metabologia
https://www.readbyqxmd.com/read/20639842/endoscopic-para-thyroidectomy-a-new-approach
#16
M M Aziz, A W Khan, M F Uddin, M A Hasanat, M A Kader, A J Chowdhury, N A Choudhury
Two patients (one male and one female) underwent endoscopic para-thyroidectomy for parathyroid adenoma at the Department of Surgery, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh. Three ports (one mid line and two laterals) were employed, a 10 mm telescope was used for the visualization and a harmonic scalpel was used for the dissection. To the best of our knowledge, there was no report of endoscopic para-thyroidectomy from Bangladesh. Both patients were fed on the first post operative day and discharged from the 4th and 8th operative day...
July 2010: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/20538257/chromogranin-a-assay-in-clinical-practice
#17
REVIEW
M d'Herbomez, C Do Cao, D Vezzosi, F Borzon-Chasot, E Baudin
Chromogranins belong to the family of secretory chromogranin and secretogranin proteins. They are found in secretory vesicles throughout the neuroendocrine system. Chromogranin A (CgA) is the main component. CgA acts as a prohormone submitted to processes of degradation through which active peptides are generated. CgA has auto, para and endocrine functions. It is widely used as an immunohistochemical marker. Despite the lack of international standardization, and the lack of an accurate definition of the diagnostic cut-off levels, some CgA assays are reliable...
September 2010: Annales D'endocrinologie
https://www.readbyqxmd.com/read/20423271/emerging-drugs-for-hyperlipidemia
#18
REVIEW
Christos Paras, M Mahmood Hussain, Robert S Rosenson
IMPORTANCE OF THE FIELD: Elevated concentrations of low-density lipoprotein (LDL) cholesterol are associated with increased risk of coronary atherosclerosis, and morbidity and mortality from coronary heart disease (CHD). Lowering of LDL cholesterol leads to a reduction in cardiovascular morbidity and all-cause mortality in individuals at risk for cardiovascular events and patients with established CHD. The mainstays of lipid lowering therapy today are the HMG-CoA reductase inhibitors (statins); however, the residual risk of cardiovascular events amongst individuals treated with statins remains a major healthcare concern...
September 2010: Expert Opinion on Emerging Drugs
https://www.readbyqxmd.com/read/19893402/early-documentation-of-therapeutic-response-at-6-weeks-following-corticosteroid-therapy-in-extensive-sarcoidosis-promise-of-fdg-pet
#19
Sandip Basu, Ramesh V Asopa, Nawab S Baghel
A 52-year-old man, who was treated with antitubercular drugs for 1 year without any benefit for an initial diagnosis of tuberculosis, and was referred for further evaluation. An FDG-PET study was performed to evaluate the whole-body disease status, which showed multiple abnormal foci in bilateral neck nodes, mediastinal, axillary, and multiple abdominal (para-aortic and inguinal) nodes, and the liver, spleen, and thyroid. A rebiopsy of the inguinal nodes for a definitive diagnosis was confirmatory of sarcoidosis...
October 2009: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/19672399/nuclear-hormone-receptor-activity-of-polybrominated-diphenyl-ethers-and-their-hydroxylated-and-methoxylated-metabolites-in-transactivation-assays-using-chinese-hamster-ovary-cells
#20
Hiroyuki Kojima, Shinji Takeuchi, Naoto Uramaru, Kazumi Sugihara, Takahiko Yoshida, Shigeyuki Kitamura
BACKGROUND: An increasing number of studies are reporting the existence of polybrominated diphenyl ethers (PBDEs) and their hydroxylated (HO) and methoxylated (MeO) metabolites in the environment and in tissues from wildlife and humans. OBJECTIVE: Our aim was to characterize and compare the agonistic and antagonistic activities of principle PBDE congeners and their HO and MeO metabolites against human nuclear hormone receptors. METHODS: We tested the hormone receptor activities of estrogen receptor alpha (ERalpha), ERbeta, androgen receptor (AR), glucocorticoid receptor (GR), thyroid hormone receptor alpha(1) (TRalpha(1)), and TRbeta(1) against PBDE congeners BDEs 15, 28, 47, 85, 99, 100, 153, and 209, four para-HO-PBDEs, and four para-MeO-PBDEs by highly sensitive reporter gene assays using Chinese hamster ovary cells...
August 2009: Environmental Health Perspectives
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