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https://www.readbyqxmd.com/read/29150860/quality-of-life-outcomes-after-subthalamic-stimulation-in-parkinson-s-disease-depends-on-age
#1
Haidar S Dafsari, Paul Reker, Lisa Stalinski, Monty Silverdale, Alexandra Rizos, Keyoumars Ashkan, Michael T Barbe, Gereon R Fink, Julian Evans, Julia Steffen, Michael Samuel, Till A Dembek, Veerle Visser-Vandewalle, Angelo Antonini, K Ray-Chaudhuri, Pablo Martinez-Martin, Lars Timmermann
OBJECTIVE: The purpose of this study was to investigate how quality of life outcome after bilateral subthalamic nucleus (STN) deep brain stimulation (DBS) in Parkinson's disease (PD) depends on age. METHODS: In this prospective, open-label, multicenter study including 120 PD patients undergoing bilateral STN-DBS, we investigated the PDQuestionnaire-8 (PDQ-8), Unified PD Rating Scale-III, Scales for Outcomes in PD-motor examination, complications, activities of daily living, and levodopa equivalent daily dose preoperatively and at 5 months follow-up...
November 18, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/29149891/how-do-occupational-rehabilitation-clinicians-approach-participants-on-long-term-sick-leave-in-order-to-facilitate-return-to-work-a-focus-group-study
#2
M Eftedal, A M Kvaal, E Ree, I Øyeflaten, S Maeland
BACKGROUND: The objective of this study was to explore occupational rehabilitation clinicians' experiences on how to approach their participants on long-term sick leave in order to facilitate return to work (RTW). METHODS: An exploratory qualitative design was used. Four focus groups were conducted with 29 clinicians working on interdisciplinary inpatient and outpatient occupational rehabilitation teams in Norway. The clinicians shared narratives from clinical practice...
November 17, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/29149826/novel-functions-of-microrna-17-92-cluster-in-the-endocrine-system
#3
Shan Wan, Xiang Chen, Yuedong He, Xijie Yu
BACKGROUND: MiR-17-92 cluster is coded by MIR17HG in chromosome 13, which is highly conserved in vertebrates. Published literatures have proved that miR-17-92 cluster critically regulates tumorigenesis and metastasis. Recent researches showed that the miR-17-92 cluster also plays novel functions in the endocrine system. OBJECTIVE: To summarize recent findings on the physiological and pathological roles of miR-17-92 cluster in bone, lipid and glucose metabolisms...
November 17, 2017: Current Drug Targets
https://www.readbyqxmd.com/read/29149485/factors-influencing-the-delivery-of-the-fundamentals-of-care-perceptions-of-nurses-nursing-leaders-and-healthcare-consumers
#4
Tiffany Conroy
AIM AND OBJECTIVES: To explore the factors described by nurses and consumer representatives influencing the delivery of the fundamentals of care. BACKGROUND: An ongoing challenge facing nursing is ensuring the 'basics' or fundamentals of care are delivered optimally. The way nurses and patients perceive the delivery of the fundamentals of care, had not been explored. Once identified, the factors that promote the delivery of the fundamentals of care may be facilitated ...
November 17, 2017: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/29149473/exploring-communication-during-the-journey-from-noticing-bodily-changes-to-a-diagnosis-of-endometrial-cancer
#5
Catherine Cook, Margaret Brunton, Tepora Pukepuke, Ai Ling Tan
AIMS AND OBJECTIVES: To understand women's perspectives about the trajectory from first bodily changes to diagnosis. BACKGROUND: With endometrial cancer, as with all gynaecological cancers, early diagnosis is key to successful outcomes. However, women do not always seek clinical advice early. Previously, this gap has been referred to as a 'delay', blamed on fear or refusal to acknowledge symptoms. METHODS: A qualitative research project which involved face-to-face interviews with 16 women who had presented with symptoms of endometrial cancer...
November 17, 2017: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/29148980/-just-don-t-be-creepy-a-phenomenological-study-of-the-experiences-of-men-in-massage-therapy
#6
Amanda Baskwill, Meredith Vanstone
Background Societal expectations around traditional binary gender roles result in some professions being considered "men's work" or "women's work". Massage therapy (MT) is one such profession that, despite being predominantly female, is joined by an increasing number of men with a desire to help others. Methods This descriptive phenomenological study asked male massage therapists in Ontario, Canada, about their experience of gender in their professional lives. Fourteen men shared their experiences of practice, which included discriminatory hiring and patient preferences for female practitioners...
November 17, 2017: Journal of Complementary & Integrative Medicine
https://www.readbyqxmd.com/read/29148566/factors-that-influence-the-provision-of-intrapartum-and-postnatal-care-by-skilled-birth-attendants-in-low-and-middle-income-countries-a-qualitative-evidence-synthesis
#7
REVIEW
Susan Munabi-Babigumira, Claire Glenton, Simon Lewin, Atle Fretheim, Harriet Nabudere
BACKGROUND: In many low- and middle-income countries women are encouraged to give birth in clinics and hospitals so that they can receive care from skilled birth attendants. A skilled birth attendant (SBA) is a health worker such as a midwife, doctor, or nurse who is trained to manage normal pregnancy and childbirth. (S)he is also trained to identify, manage, and refer any health problems that arise for mother and baby. The skills, attitudes and behaviour of SBAs, and the extent to which they work in an enabling working environment, impact on the quality of care provided...
November 17, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29148148/an-integrative-translational-approach-to-study-heart-failure-with-preserved-ejection-fraction-a-position-paper-from-the-working-group-on-myocardial-function-of-the-european-society-of-cardiology
#8
REVIEW
Andre P Lourenço, Adelino F Leite-Moreira, Jean-Luc Balligand, Johann Bauersachs, Dana Dawson, Rudolf A de Boer, Leon J de Windt, Inês Falcão-Pires, Ricardo Fontes-Carvalho, Stefan Franz, Mauro Giacca, Denise Hilfiker-Kleiner, Emilio Hirsch, Christoph Maack, Manuel Mayr, Burkert Pieske, Thomas Thum, Carlo G Tocchetti, Dirk L Brutsaert, Stephane Heymans
As heart failure with preserved ejection fraction (HFpEF) rises to epidemic proportions, major steps in patient management and therapeutic development are badly needed. With the current position paper we seek to update our view on HFpEF as a highly complex systemic syndrome, from risk factors and mechanisms to long-term clinical manifestations. We will revise recent advances in animal model development, experimental set-ups and basic and translational science approaches to HFpEF research, highlighting their drawbacks and advantages...
November 16, 2017: European Journal of Heart Failure
https://www.readbyqxmd.com/read/29148147/altered-n170-and-mood-symptoms-in-bipolar-disorder-an-electrophysiological-study-of-configural-face-processing
#9
Ivy F Tso, Tyler B Grove, Savanna A Mueller, Lisa O'Donnell, Jinsoo Chun, Melvin G McInnis, Patricia J Deldin
OBJECTIVES: Altered social behavior during mood episodes in bipolar disorder often has detrimental and long-lasting interpersonal consequences. Abnormal face processing may play a role in linking brain functions to clinical symptoms and behavior. This study aimed to understand configural face processing in bipolar disorder as a function of basic communicative attributes of the face and mood symptoms using event-related brain potentials (ERPs). METHODS: Forty-two participants with bipolar I disorder (BP) and 43 healthy controls (HC) viewed face stimuli varying in emotion (neutral or fearful), head orientation (forward or deviated), and gaze direction (direct or averted) while ERPs were recorded...
November 17, 2017: Bipolar Disorders
https://www.readbyqxmd.com/read/29147646/creation-and-pilot-testing-of-cases-for-case-based-learning-a-pedagogical-approach-for-pathology-cancer-diagnosis
#10
Shahin Sayed, Susan C Lester, Michael Wilson, Daniel Berney, Ricard Masia, Zahir Moloo, Jennifer Stall, Alexia Eslan, Stephanie Ayers, Angela Mutuku, Jeannette Guarner
Background: Case-based learning (CBL) is an established pedagogical active learning method used in various disciplines and defined based on the field of study and type of case. The utility of CBL for teaching specific aspects of cancer diagnosis to practising pathologists has not been previously studied in sub-Saharan Africa. Objectives: We aimed to pilot test standardised cancer cases on a group of practising pathologists in sub-Saharan Africa to evaluate case content, clarity of questions and delivery of content...
2017: African Journal of Laboratory Medicine
https://www.readbyqxmd.com/read/29147630/sulforaphane-from-broccoli-reduces-symptoms-of-autism-a-follow-up-case-series-from-a-randomized-double-blind-study
#11
Rhoda Lynch, Eileen L Diggins, Susan L Connors, Andrew W Zimmerman, Kanwaljit Singh, Hua Liu, Paul Talalay, Jed W Fahey
Introduction: Autism spectrum disorder (ASD) affects 1 in 68 children, is characterized by impaired social interaction and communication as well as restricted or repetitive behaviors, and varies widely with respect to its causes and presentations. There are no validated pharmacologic treatments for the core symptoms of ASD. The social, medical, and economic burdens of ASD on families and caregivers are profound. We recently showed in a small clinical trial that sulforaphane (SF) from broccoli sprouts could significantly reduce the behavioral symptoms of ASD...
2017: Global Advances in Health and Medicine: Improving Healthcare Outcomes Worldwide
https://www.readbyqxmd.com/read/29147622/factors-released-by-the-tumor-far-microenvironment-are-decisive-for-pancreatic-adenocarcinoma-development-and-progression
#12
REVIEW
Juan L Iovanna, Daniel Closa
The REG3β protein was identified more than 2 decades ago, but its role in PDAC development was only recently reported. In Pancreatic Ductal Adenocarcinoma (PDAC), REG3β protein is expressed and released by the far microenvironment, which is situated out of the tumor, at the periphery of the tumor mass, and is part of the healthy peri-tumoral region. This compartment is completely unrelated to the classical microenvironment that corresponds to the intra-tumoral stoma. Clinically relevant, the far microenvironment, and the factors released by it, could be novel and original therapeutic targets for treating patients with a PDAC...
2017: Oncoimmunology
https://www.readbyqxmd.com/read/29147056/organizing-integrated-health-care-services-to-meet-older-people-s-needs
#13
Islene Araujo de Carvalho, JoAnne Epping-Jordan, Anne Margriet Pot, Edward Kelley, Nuria Toro, Jotheeswaran A Thiyagarajan, John R Beard
In most countries, a fundamental shift in the focus of clinical care for older people is needed. Instead of trying to manage numerous diseases and symptoms in a disjointed fashion, the emphasis should be on interventions that optimize older people's physical and mental capacities over their life course and that enable them to do the things they value. This, in turn, requires a change in the way services are organized: there should be more integration within the health system and between health and social services...
November 1, 2017: Bulletin of the World Health Organization
https://www.readbyqxmd.com/read/29145897/it-does-matter-where-you-come-from-mothers-experiences-of-childbirth-in-midwife-obstetric-units-tshwane-south-africa
#14
Sarie J Oosthuizen, Anne-Marie Bergh, Robert C Pattinson, Jackie Grimbeek
BACKGROUND: Health professionals are striving to improve respectful care for women, but they fall short in the domains of effective communication, respectful and dignified care and emotional support during labour. This study aimed to determine women's experiences of childbirth with a view to improving respectful clinical care practices in low-risk, midwife-led obstetric units in the Tshwane District Health District, South Africa. METHODS: A survey covering all midwife-led units in the district was conducted among 653 new mothers...
November 16, 2017: Reproductive Health
https://www.readbyqxmd.com/read/29145178/minor-hemisphere-major-syndromes
#15
Antonio Carota, Julien Bogousslavsky
A right "minor hemisphere" does not exist as the right hemisphere is dominant for awareness (nosognosia), spatial attention, emotional regulation, facial and voice expressions, visual recognition, and topographical orientation. Without the right hemisphere, the world would be flat, deprived of general and spatial attentions, pointing preferentially to the right side of the space, lacking visual experiences and emotions, exhibiting diminished awareness of the self and environment. Clinical-related syndromes of the right hemisphere are unilateral spatial neglect, object and face visual agnosia, the anosognosia for hemiparesis and/or hemianopia, misidentification syndromes, mania, and other obsessions for the food and the body...
2018: Frontiers of Neurology and Neuroscience
https://www.readbyqxmd.com/read/29145030/the-use-of-econsults-to-improve-access-to-specialty-care-in-thrombosis-medicine
#16
Leslie Skeith, Medina Mohamed, Alan Karovitch, Clare Liddy, Amir Afkham, Douglas Archibald, Erin Keely
INTRODUCTION: Electronic consultations (eConsults) are asynchronous, consultative electronic-based communications that are aimed to improve efficient and timely access to specialist advice. Our study aim was to evaluate the use and impact of the Canadian Champlain BASE™ (Building Access to Specialists through eConsultation) eConsult service in the specialty of thrombosis medicine. METHODS: We conducted a cross-sectional study that included descriptive statistics of provider and patient demographic information and consultative-specific data...
November 7, 2017: Thrombosis Research
https://www.readbyqxmd.com/read/29144999/communicating-out-loud-midwifery-students-experiences-of-a-simulation-exercise-for-neonatal-resuscitation
#17
Mary Carolan-Olah, Gina Kruger, Vera Brown, Felicity Lawton, Melissa Mazzarino, Vidanka Vasilevski
Midwifery students feel unprepared to deal with commonly encountered emergencies, such as neonatal resuscitation. Clinical simulation of emergencies may provide a safe forum for students to develop necessary skills. A simulation exercise, for neonatal resuscitation, was developed and evaluated using qualitative methods. Pre and post-simulation questions focussed on student confidence and knowledge of resuscitation. Data were analysed using a thematic analysis approach. Pre-simulation questions revealed that most students considered themselves not very confident/unsure about their level of confidence in undertaking neonatal resuscitation...
October 23, 2017: Nurse Education in Practice
https://www.readbyqxmd.com/read/29144184/rates-and-predictors-of-professional-interpreting-provision-for-patients-with-limited-english-proficiency-in-the-emergency-department-and-inpatient-ward
#18
Jennifer Ryan, Samantha Abbato, Ristan Greer, Petra Vayne-Bossert, Phillip Good
The provision of professional interpreting services in the hospital setting decreases communication errors of clinical significance and improves clinical outcomes. A retrospective audit was conducted at a tertiary referral adult hospital in Brisbane, Australia. Of 20 563 admissions of patients presenting to the hospital emergency department (ED) and admitted to a ward during 2013-2014, 582 (2.8%) were identified as requiring interpreting services. In all, 19.8% of admissions were provided professional interpreting services in the ED, and 26...
January 2017: Inquiry: a Journal of Medical Care Organization, Provision and Financing
https://www.readbyqxmd.com/read/29143585/having-the-conversation-about-work-with-people-with-multiple-sclerosis-a-guide-for-healthcare-professionals
#19
Antonella Cardone
The ability to work is important for people with multiple sclerosis (MS). However, only 37% of those with mild MS are in work. Across Europe, lost work productivity accounts for a third of the €15 billion total annual cost of MS. Supporting people with MS into employment should be a clinical care priority in order to maximize work productivity, inclusiveness and therapeutic benefit. A guide for healthcare professionals on having conversations about work with people with MS has been developed through the 'Ready for Work' project...
November 2017: Neurodegenerative Disease Management
https://www.readbyqxmd.com/read/29142579/pakistan-s-recommendations-for-optimal-management-of-diabetes-from-primary-to-tertiary-care-level-prompt
#20
A Samad Shera, Abdul Basit, Prompt Team
Pakistan is a developing country with limited resources and diverse socio-economic standards. Pakistan has high prevalence of diabetes and its complications, which is a great challenge to the existing health care system. National action plans for control of diabetes have been developed and initiatives have been taken but not at an ideal pace. First National Practice Guidelines for Pakistan were published in 1999. It was very helpful in standardizing the management of Type-2 diabetes. In view of important developments in the field of diabetes during the recent years, it was felt that 1999 National Clinical Practice Guidelines edited, should be revised...
September 2017: Pakistan Journal of Medical Sciences Quarterly
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