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https://www.readbyqxmd.com/read/28551750/modelling-autistic-neurons-with-induced-pluripotent-stem-cells
#1
Annie Kathuria, Carlo Sala, Chiara Verpelli, Jack Price
Autism spectrum disorder (ASD) is a neurodevelopmental condition that affects more than 1% of children per current estimates. It has been characterised by the following two core behavioural phenotypes: (1) deficits in social interaction and communication and (2) repetitive behaviours, restricted interests and activities. Due to the complex nature of ASD, there are currently no effective treatments. The reason behind this is the clinical and genetic heterogeneity between affected individuals on the one hand and the lack of understanding of the underpinning pathophysiological mechanisms on the other hand...
2017: Advances in Anatomy, Embryology, and Cell Biology
https://www.readbyqxmd.com/read/28550999/process-mining-routinely-collected-electronic-health-records-to-define-real-life-clinical-pathways-during-chemotherapy
#2
Karl Baker, Elaine Dunwoodie, Richard G Jones, Alex Newsham, Owen Johnson, Christopher P Price, Jane Wolstenholme, Jose Leal, Patrick McGinley, Chris Twelves, Geoff Hall
BACKGROUND: There is growing interest in the use of routinely collected electronic health records to enhance service delivery and facilitate clinical research. It should be possible to detect and measure patterns of care and use the data to monitor improvements but there are methodological and data quality challenges. Driven by the desire to model the impact of a patient self-test blood count monitoring service in patients on chemotherapy, we aimed to (i) establish reproducible methods of process-mining electronic health records, (ii) use the outputs derived to define and quantify patient pathways during chemotherapy, and (iii) to gather robust data which is structured to be able to inform a cost-effectiveness decision model of home monitoring of neutropenic status during chemotherapy...
July 2017: International Journal of Medical Informatics
https://www.readbyqxmd.com/read/28550997/prescription-errors-related-to-the-use-of-computerized-provider-order-entry-system-for-pediatric-patients
#3
Kamel Alhanout, Sok-Siya Bun, Karine Retornaz, Laurent Chiche, Nathalie Colombini
OBJECTIVES: To evaluate the nature and frequency of medication errors resulting from the use of a computerized provider order-entry (CPOE) system in a pediatric department. METHODS: We conducted a retrospective study to examine errors related to computerized orders using the software Pharma(®) (Computer Engineering, France) in pediatric department between 31/05/2015 to 01/12/2015. These errors were signaled by pharmacists who examine CPOEs daily. RESULTS: A total of 302 pharmacist interventions (PharmInt) were carried out by clinical pharmacists during the study period...
July 2017: International Journal of Medical Informatics
https://www.readbyqxmd.com/read/28550968/clinical-audits-to-improve-critical-care-part-1-prepare-and-collect-data
#4
Amanda J Ullman, Gillian Ray-Barruel, Claire M Rickard, Marie Cooke
Clinical audits are used to examine current practice, compare this with established best practice and implementing change, to ensure patients receive the most effective treatment. They are successful in improving the quality and safety of care provided, and thereby clinical outcomes. Clinical audits are ubiquitous throughout critical care practice, but without the necessary focus, engagement, preparation, method, evaluation and communication, they may be a waste of resources. This article is the first of a two-paper series regarding audits in critical care...
May 24, 2017: Australian Critical Care: Official Journal of the Confederation of Australian Critical Care Nurses
https://www.readbyqxmd.com/read/28549984/smfm-special-report-the-development-and-implementation-of-checklists-in-obstetrics
#5
Peter S Bernstein, C Andrew Combs, Laurence E Shields, Steven L Clark, Catherine S Eppes
Checklists have been long used as a cognitive aid in various high-stakes environments to improve the reliability and performance of individuals and teams. When designed well, implemented thoughtfully, and monitored closely, they offer the opportunity to improve the performance of health care teams and advance patient safety. There are different types of checklists; examples include task lists, troubleshooting lists, coordination lists, discipline lists, and to-do lists. Each is useful in different situations and requires different implementation strategies...
May 23, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28549743/intensive-care-nursing-students-perceptions-of-simulation-for-learning-confirming-communication-skills-a-descriptive-qualitative-study
#6
Marte-Marie Wallander Karlsen, Anita Kristin Gabrielsen, Anne Lise Falch, Dag-Gunnar Stubberud
AIM: The aim of this study was to explore intensive care nursing students experiences with confirming communication skills training in a simulation-based environment. RESEARCH METHODOLOGY: The study has a qualitative, exploratory and descriptive design. The participants were students in a post-graduate program in intensive care nursing, that had attended a one day confirming communication course. Three focus group interviews lasting between 60 and 80min were conducted with 14 participants...
May 23, 2017: Intensive & Critical Care Nursing: the Official Journal of the British Association of Critical Care Nurses
https://www.readbyqxmd.com/read/28549668/patient-perspectives-on-diabetes-care-across-the-institute-of-medicine-s-six-domains-of-quality
#7
I J Halperin, G Mukerji, M Maione, P Segal, M Wolfs, J Goguen, L Jeffs
OBJECTIVES: To gather patient perspectives on quality of care provided in diabetes clinics within the framework of the Institute of Medicine's 6 domains of quality. METHODS: A qualitative study including semi-structured interviews was conducted at 5 academic hospital sites. Transcripts were analyzed using a direct content approach for themes and subthemes with saturation of themes achieved. Purposive sampling was conducted at 5 diabetes clinics (n=47 interviews)...
May 23, 2017: Canadian Journal of Diabetes
https://www.readbyqxmd.com/read/28549460/learning-to-use-electronic-health-records-can-we-stay-patient-centered-a-pre-post-intervention-study-with-family-medicine-residents
#8
Cédric Lanier, Melissa Dominicé Dao, Patricia Hudelson, Bernard Cerutti, Noëlle Junod Perron
BACKGROUND: The Electronic Health Record (EHR) is now widely used in clinical encounters. Because its use can negatively impact the physician-patient relationship, several recommendations on the "patient-centered" use of the EHR have been published. However, the impact of training to improve EHR use during clinical encounters is not well known. The aim of this study was to assess the impact of training on residents' EHR-related communication skills and explore whether they varied according to the content of the consultation...
May 26, 2017: BMC Family Practice
https://www.readbyqxmd.com/read/28549459/-a-steep-learning-curve-junior-doctor-perspectives-on-the-transition-from-medical-student-to-the-health-care-workplace
#9
Nancy Sturman, Zachary Tan, Jane Turner
BACKGROUND: The transition from medical student to hospital-based first year junior doctor (termed "intern" in Australia) is known to be challenging, and recent changes in clinical learning environments may reduce graduate preparedness for the intern workplace. Although manageable challenges and transitions are a stimulus to learning, levels of burnout in junior medical colleagues are concerning. In order to prepare and support medical graduates, educators need to understand contemporary junior doctor perspectives on this transition...
May 26, 2017: BMC Medical Education
https://www.readbyqxmd.com/read/28549250/the-clinical-communication-and-information-challenges-associated-with-the-psychosexual-aspects-of-prostate-cancer-treatment
#10
Susan A Speer, Samantha R Tucker, Rebecca McPhillips, Sarah Peters
RATIONALE: Prostate cancer and its treatment have significant sexual side effects that necessitate timely patient information and open communication with healthcare professionals. However, very little is known about men's experiences of talking to clinicians about the psychosexual difficulties associated with the disease. OBJECTIVE: This study aims to advance understanding of men's perceptions of the communication and information challenges associated with the psychosexual aspects of prostate cancer and its treatment...
May 18, 2017: Social Science & Medicine
https://www.readbyqxmd.com/read/28548368/developing-minimum-clinical-standards-for-physiotherapy-in-south-african-icus-a-qualitative-study
#11
Heleen van Aswegen, Shane Patman, Natascha Plani, Susan Hanekom
RATIONALE, AIMS, AND OBJECTIVES: Physiotherapists are integral members of the intensive care unit (ICU) team. Clinicians working in ICU are dependent on their own experience when making decisions regarding individual patient management thus resulting in variation in clinical practice. No formalized clinical practice guidelines or standards exist for the educational profile or scope of practice requirements for ICU physiotherapy. This study explored perceptions of physiotherapists on minimum clinical standards that ICU physiotherapists should adhere to for delivering safe, effective physiotherapy services to critically ill patients...
May 26, 2017: Journal of Evaluation in Clinical Practice
https://www.readbyqxmd.com/read/28547010/language-development-and-impairment-in-children-with-mild-to-moderate-sensorineural-hearing-loss
#12
Lorna F Halliday, Outi Tuomainen, Stuart Rosen
Purpose: The goal of this study was to examine language development and factors related to language impairments in children with mild to moderate sensorineural hearing loss (MMHL). Method: Ninety children, aged 8-16 years (46 children with MMHL; 44 aged-matched controls), were administered a battery of standardized language assessments, including measures of phonological processing, receptive and expressive vocabulary and grammar, word and nonword reading, and parental report of communication skills...
May 24, 2017: Journal of Speech, Language, and Hearing Research: JSLHR
https://www.readbyqxmd.com/read/28546849/why-a-registry-of-chronic-urticaria-cur-is-needed
#13
R M Gómez, E Jares, G W Canonica, I Baiardini, G Passalacqua, M Sánchez Borges, A P Kaplan, Carlos E Baena-Cagnani
Chronic urticaria (CU) has a major effect on patients' quality of life. While there have been progressive advances regarding its pathogenesis and treatment, much remains to be done. Registries of other chronic non-communicable diseases have shown many benefits, such as additional basic knowledge and management approaches to diabetes mellitus. Standards of care as well as diagnostic approaches can be elaborated and compared from different sites, using validated instruments. Registries in allergic diseases are also becoming well recognized, and the first registry on CU, accessible from SLaai's webpage, includes parameters for identification, evaluation and management...
2017: World Allergy Organization Journal
https://www.readbyqxmd.com/read/28546619/the-dental-practicality-index-assessing-the-restorability-of-teeth
#14
A Dawood, S Patel
The Dental Practicality Index (DPI) has been designed to describe on a clinical level, the 'practicality' of dental restorative treatment. Applicable to everyday clinical practice, the DPI also aims to assist the clinician in deciding when to seek advice and/or refer a patient for secondary or tertiary dental care. It is hoped that this tool will aid in the systematic assessment of dental restorative problems, enhance communication between collaborating practitioners and help to manage patient expectations before carrying out restorative treatment(s)...
May 26, 2017: British Dental Journal
https://www.readbyqxmd.com/read/28546311/evidence-for-functional-networks-within-the-human-brain-s-white-matter
#15
Michael Peer, Mor Nitzan, Atira S Bick, Netta Levin, Shahar Arzy
Investigation of the functional macro-scale organization of the human cortex is fundamental in modern neuroscience. While numerous studies have identified networks of interacting functional modules in the grey-matter, limited research was directed to the functional organization of the white-matter. Recent studies have demonstrated that the white-matter exhibits blood oxygen level dependent (BOLD) signal fluctuations similar to those of the grey-matter. Here we used these signal fluctuations to investigate whether the white-matter is organized as functional networks by applying a clustering analysis on resting-state functional MRI (RSfMRI) data from white-matter voxels, in 176 subjects (of both sexes)...
May 25, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28546093/best-practice-guidance-for-the-use-of-strategies-improved-retention-in-randomised-trials-developed-from-two-consensus-workshops
#16
V Brueton, S P Stenning, F Stevenson, J Tierney, G Rait
OBJECTIVE: To develop best practice guidance for the use of retention strategies in randomised clinical trials (RCTs). DESIGN: Consensus development workshops. SETTING: Two UK Clinical Trials Units. PARTICIPANTS: 66 statisticians, clinicians, RCT coordinators, research scientists, research assistants, and data managers associated with RCTs. METHODS: The consensus development workshops were based on the consensus development conference method used to develop best practice for treatment of medical conditions...
May 22, 2017: Journal of Clinical Epidemiology
https://www.readbyqxmd.com/read/28546052/status-report-from-norway-implementation-of-patient-involvement-in-norwegian-health-care
#17
Jürgen Kasper, Anne Regine Lager, Markus Rumpsfeld, Simone Kienlin, Kristine Hoel Smestad, Tone Bråthen, Holly Ankell, Tore Knutsen, Rune Kløvtveit, Pål Gulbrandsen, Per Olav Vandvik, Anja Fog Heen, Signe Flottorp, Geir Tollåli, Øystein Eiring
Norway has traditionally high standards regarding civil rights particularly emphasizing equal access to societal resources including health care. This background and the health care system's centralized national organization make it perfectly suited for implementation of shared decision making (SDM). In recent years, great efforts have been made by policy- makers, regional health authorities and not least the patients to facilitate a process of change in health communication culture. SDM is currently even given highest priority in health care strategies on all system levels...
May 22, 2017: Zeitschrift Für Evidenz, Fortbildung und Qualität Im Gesundheitswesen
https://www.readbyqxmd.com/read/28546050/shared-decision-making-in-argentina-in-2017
#18
Mariela Barani, Karin Kopitowski, Carolina Carrara, María Victoria Ruiz Yanzi
Argentina is a high-middle income country located in Southern South America with an estimated population of 44 million inhabitants. The epidemiological profile of the population is characterised by an increase of non-communicable diseases. The health system is heterogeneous, fragmented and loosely integrated. There are no unified research agenda or government initiatives encouraging the implementation of and research on Shared Decision-Making (SDM). Progress has been made lately to respect patient autonomy through the enactment of the 'Patients' Rights Act', which expressly enshrines the right of patients to get information as a key element of decision-making...
May 22, 2017: Zeitschrift Für Evidenz, Fortbildung und Qualität Im Gesundheitswesen
https://www.readbyqxmd.com/read/28545598/indonesian-dengue-burden-estimates-review-of-evidence-by-an-expert-panel
#19
T Y M Wahyono, J Nealon, S Beucher, A Prayitno, A Moureau, S Nawawi, H Thabrany, M Nadjib
Routine, passive surveillance systems tend to underestimate the burden of communicable diseases such as dengue. When empirical methods are unavailable, complimentary opinion-based or extrapolative methods have been employed. Here, an expert Delphi panel estimated the proportion of dengue captured by the Indonesian surveillance system, and associated health system parameters. Following presentation of medical and epidemiological data and subsequent discussions, the panel made iterative estimates from which expansion factors (EF), the ratio of total:reported cases, were calculated...
May 26, 2017: Epidemiology and Infection
https://www.readbyqxmd.com/read/28545539/the-role-of-nature-in-cancer-patients-lives-a-systematic-review-and-qualitative-meta-synthesis
#20
Sarah Blaschke
BACKGROUND: A systematic review and meta-synthesis was conducted to identify, compare and synthesize the published qualitative literature contributing to our understanding of the role of nature in cancer patients' lives. METHOD: An electronic search of Medline, CINAHL, PsycINFO and Cochrane Databases was conducted to identify qualitative studies focused on cancer patients' nature experiences published between January 1985 and May 2015. Records were assessed according to pre-defined inclusion criteria...
May 25, 2017: BMC Cancer
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