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https://www.readbyqxmd.com/read/29771135/electromembrane-extraction-of-substances-with-weakly-basic-properties-a-fundamental-study-with-benzodiazepines
#1
Linda Vårdal, Elisabeth L Øiestad, Astrid Gjelstad, Stig Pedersen-Bjergaard
AIM: Electromembrane extraction (EME) of weakly basic benzodiazepines was investigated (-1.47 < pKa < 5.01). MATERIALS & METHODS: 96-well EME was performed with strongly acidic conditions in the acceptor solution using 250-mM trifluoroacetic acid to maximize ionization. RESULTS & CONCLUSION: Recoveries more than 80% were obtained for analytes with pKa > 2, whereas EME was less efficient for substances with pKa < 2...
May 17, 2018: Bioanalysis
https://www.readbyqxmd.com/read/29769827/effects-of-a-4-week-very-low-carbohydrate-diet-on-high-intensity-interval-training-responses
#2
Lukas Cipryan, Daniel J Plews, Alessandro Ferretti, Phil B Maffetone, Paul B Laursen
The purpose of the study was to examine the effects of altering from habitual mixed Western-based (HD) to a very low-carbohydrate high-fat (VLCHF) diet over a 4-week timecourse on performance and physiological responses during high-intensity interval training (HIIT). Eighteen moderately trained males (age 23.8 ± 2.1 years) consuming their HD (48 ± 13% carbohydrate, 17 ± 3% protein, 35 ± 9% fat) were assigned to 2 groups. One group was asked to remain on their HD, while the other was asked to switch to a non-standardized VLCHF diet (8 ± 3% carbohydrate, 29 ± 15% protein, 63 ± 13% fat) for 4 weeks...
June 2018: Journal of Sports Science & Medicine
https://www.readbyqxmd.com/read/29758055/active-recovery-affects-the-recovery-of-the-corticospinal-system-but-not-of-muscle-contractile-properties
#3
Louis-Solal Giboin, Ehsan Amiri, Raphael Bertschinger, Markus Gruber
PURPOSE: Active recovery is often used by athletes after strenuous exercise or competition but its underlying mechanisms are not well understood. We hypothesized that active recovery speeds-up recovery processes within the muscle and the central nervous system (CNS). METHODS: We assessed muscular and CNS recovery by measuring the voluntary activation (VA) in the vastus lateralis muscle with transcranial magnetic stimulation (VATMS) and peripheral nerve stimulation (VAPNS) during maximal voluntary contractions (MVC) of the knee extensors in 11 subjects...
2018: PloS One
https://www.readbyqxmd.com/read/29755204/cryopreservation-studies-of-an-artificial-co-culture-between-the-cobalamin-requiring-green-alga-lobomonas-rostrata-and-the-bacterium-mesorhizobium-loti
#4
Christian J A Ridley, John G Day, Alison G Smith
Algal-bacterial co-cultures, rather than cultures of algae alone, are regarded as having the potential to enhance productivity and stability in industrial algal cultivation. As with other inocula in biotechnology, to avoid loss of production strains, it is important to develop preservation methods for the long-term storage of these cultures, and one of the most commonly used approaches is cryopreservation. However, whilst there are many reports of cryopreserved xenic algal cultures, little work has been reported on the intentional preservation of both algae and beneficial bacteria in xenic cultures...
2018: Journal of Applied Phycology
https://www.readbyqxmd.com/read/29754065/role-preferences-of-patients-with-alcohol-use-disorders
#5
Anke Friedrichs, Anna Silkens, Jens Reimer, Ludwig Kraus, Norbert Scherbaum, Daniela Piontek, Jeanette Röhrig, Jochen Hempleman, Martin Härter, Angela Buchholz
AIMS: Shared decision making (SDM) is increasingly demanded in medical decision making. SDM acknowledges patients' role preferences in decision making processes. There has been limited research on SDM and role preferences in substance use disorders; results are promising. Aim of this study was to investigate role preferences of patients with alcohol use disorders (AUD), and to identify predictors of these preferences. METHOD: Cross-sectional data collected from June 2013 to May 2014 in four detoxification wards in Germany during a randomised controlled trial (RCT, Registration Code 01GY1114) was analysed...
May 4, 2018: Addictive Behaviors
https://www.readbyqxmd.com/read/29748911/patient-education-and-rehabilitation-after-hip-arthroplasty-in-an-italian-spa-center-a-pilot-study-on-its-feasibility
#6
Alfredo Musumeci, Giulia Pranovi, Stefano Masiero
Nowadays, some spa centers are suitable for providing rehabilitative and preventive treatment in association with traditional spa therapy. This study aims to evaluate the feasibility and the effectiveness of an intensive rehabilitation program after hip arthroplasty in an Italian spa center. Early after total hip arthroplasty for severe osteoarthritis (≤ 10 days after the intervention), 12 consecutive patients (5 males and 7 females) aged between 50 and 85 years were enrolled for this study. All the patients performed a 2-week thermal multimodal rehabilitation program, which consisted of education and physical rehabilitative measures...
May 11, 2018: International Journal of Biometeorology
https://www.readbyqxmd.com/read/29746386/whole-body-high-intensity-interval-training-induce-similar-cardiorespiratory-adaptations-compared-with-traditional-high-intensity-interval-training-and-moderate-intensity-continuous-training-in-healthy-men
#7
Gustavo Z Schaun, Stephanie S Pinto, Mariana R Silva, Davi B Dolinski, Cristine L Alberton
Schaun, GZ, Pinto, SS, Silva, MR, Dolinski, DB, and Alberton, CL. Sixteen weeks of whole-body high-intensity interval training induce similar cardiorespiratory responses compared with traditional high-intensity interval training and moderate-intensity continuous training in healthy men. J Strength Cond Res XX(X): 000-000, 2018-Low-volume high-intensity interval training (HIIT) protocols that use the body weight as resistance could be an interesting and inexpensive alternative to traditional ergometer-based high-intensity interval training (HIIT-T) and moderate-intensity continuous training (MICT)...
May 7, 2018: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/29745801/cold-water-immersion-after-training-sessions-effects-on-fiber-type-specific-adaptations-in-muscle-k-transport-proteins-to-sprint-interval-training-in-men
#8
Danny Christiansen, David John Bishop, James R Broatch, Jens Bangsbo, Michael John McKenna, Robyn M Murphy
Effects of regular use of cold-water immersion (CWI) on fiber type-specific adaptations in muscle K+ transport proteins to intense training, along with their relationship to changes in mRNA levels after the first training session, were investigated in humans. Nineteen recreationally-active men (24{plus minus}6 y, 79.5{plus minus}10.8 kg, 44.6{plus minus}5.8 mL∙kg-1 ∙min-1 ) completed six weeks of sprint-interval cycling either without (passive rest; CON) or with training sessions followed by CWI (15 min at 10{degree sign}C; COLD)...
May 10, 2018: Journal of Applied Physiology
https://www.readbyqxmd.com/read/29745738/effect-of-prior-fatiguing-sport-specific-exercise-on-field-hockey-passing-ability
#9
Enzo Hollville, Vincent Le Croller, Yoshihiro Hirasawa, Rémi Husson, Giuseppe Rabita, Franck Brocherie
PURPOSE: This study aimed to evaluate the effect of multiple sets of repeated-sprint ability (RSA) induced fatigue on subsequent passing skill performance among field hockey. METHODS: Ten elite U-21 male field hockey players performed five sets of a combination of RSA test (6 × 20 m - 20 s of passive recovery) followed by a 1-min passing skill test (passing reception with subsequent passes at a pre-designed target). Fastest sprint time and cumulated sprint time for RSA test; total number of balls played, targeted and passing accuracy (number of balls targeted / total number of balls played) for passing skill test; heart rate (HR), blood lactate concentration ([La-]) and rating of perceived exertion (RPE) were collected throughout the protocol...
May 10, 2018: International Journal of Sports Physiology and Performance
https://www.readbyqxmd.com/read/29743361/a-novel-strategy-to-adapt-shiv-e1-carrying-env-from-an-rv144-volunteer-to-rhesus-macaques-coreceptor-switch-and-final-recovery-of-a-pathogenic-virus-with-exclusive-r5-tropism
#10
Hanna B Scinto, Sandeep Gupta, Swati Thorat, Muhammad M Mukhtar, Anthony Griffiths, Jennifer Delgado, Elizabeth Plake, Hemant K Vyas, Amanda Strickland, Siddappa N Byrareddy, David C Montefiori, Celia LaBranche, Ranajit Pal, Jim Treece, Sharon Orndorff, Maria Grazia Ferrari, Deborah Weiss, Agnes-Laurence Chenine, Robert McLinden, Nelson Michael, Jerome H Kim, Merlin Robb, Supachai Rerks-Ngarm, Punnee Pitisuttithum, Sorachai Nitayaphan, Ruth M Ruprecht
The Phase III RV144 HIV vaccine trial conducted in Thailand remains the only study to show efficacy in decreasing HIV acquisition risk. In Thailand, circulating recombinant forms of HIV clades A/E (CRF01_AE) predominate; in such viruses, env originates from clade E (HIV-E). We constructed a simian-human immunodeficiency virus (SHIV) chimera carrying env isolated from an RV144 placebo recipient in the SHIV-1157ipd3N4 backbone. The latter contains long terminal repeats (LTRs) with duplicated NF-κB sites, thus resembling HIV LTRs...
May 9, 2018: Journal of Virology
https://www.readbyqxmd.com/read/29729641/analysis-of-nicotine-and-cotinine-in-hair-by-on-line-in-tube-solid-phase-microextraction-coupled-with-liquid-chromatography-tandem-mass-spectrometry-as-biomarkers-of-exposure-to-tobacco-smoke
#11
Takehito Inukai, Sanae Kaji, Hiroyuki Kataoka
Smoking not only increases the risk of lung cancer but is strongly related to the onset of cardiovascular disease. Particularly, passive smoking due to sidestream smoke is a critical public health problem. To assess active and passive exposure to tobacco smoke, we developed a simple and sensitive method, consisting of on-line in-tube solid phase microextraction (SPME) coupled with liquid chromatography-tandem mass spectrometry (LC-MS/MS), to determine nicotine and its metabolite cotinine in hair samples. These compounds were separated within 5 min using a Polar-RP80A column and detected in the positive ion mode by multiple reaction monitoring...
April 30, 2018: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29721434/physiological-parameter-values-in-greyhounds-before-and-after-high-intensity-exercise
#12
Francisco Javier Pellegrino, Analía Risso, Pablo G Vaquero, Yanina A Corrada
Dog sports competitions have greatly expanded. The availability of reference values for each type of activity could help assess fitness accurately. Heart rate (HR), blood lactate (BL) and rectal temperature (RT) are relevant physiological parameters to determine the dogs response to effort. Previous studies in greyhounds have reported the effect of high-intensity exercise on many physiological parameters immediately after completing different racing distances and recovery times. However, there are no studies concerning physiological changes over shorter racing distances...
2018: Open Veterinary Journal
https://www.readbyqxmd.com/read/29720949/active-recovery-after-high-intensity-interval-training-does-not-attenuate-training-adaptation
#13
Thimo Wiewelhove, Christoph Schneider, Alina Schmidt, Alexander Döweling, Tim Meyer, Michael Kellmann, Mark Pfeiffer, Alexander Ferrauti
Objective: High-intensity interval training (HIIT) can be extremely demanding and can consequently produce high blood lactate levels. Previous studies have shown that lactate is a potent metabolic stimulus, which is important for adaptation. Active recovery (ACT) after intensive exercise, however, enhances blood lactate removal in comparison with passive recovery (PAS) and, consequently, may attenuate endurance performance improvements. Therefore, the aim of this study was to examine the influence of regular ACT on training adaptations during a HIIT mesocycle...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29716087/high-order-soliton-evolution-and-pulse-breaking-recovery-in-stretched-ultrafast-fiber-lasers
#14
Yueqing Du, Xuewen Shu, Hao Zhang, Peiyun Cheng
We present a new pulse regime in a stretched ultrafast fiber laser based on numerical simulations. The pulse breaking due to high-order soliton evolution in the passive fiber is recovered to a smooth pulse in the gain fiber with normal dispersion. The new pulse regime formed by the two nonlinear processes makes the ultrafast fiber laser generate ultra-broadband, ultrashort duration, high energy and large breathing ratio pulses. Our work gives insights into the nonlinear dynamics in fiber lasers and has potential for a better design of the stretched fiber lasers...
April 30, 2018: Optics Express
https://www.readbyqxmd.com/read/29704656/person-centered-analysis-of-psychological-traits-to-explain-heterogeneity-in-patient-reported-outcomes-of-coronary-artery-disease-the-thoresci-study
#15
Eveline van Montfort, Nina Kupper, Jos Widdershoven, Johan Denollet
BACKGROUND: Heterogeneity in the prognosis of coronary artery disease (CAD) patients may be explained by relatively stable individual psychological differences. Therefore, we studied multiple personality and coping traits using a person-centered approach, and examined the predictive value of this approach for patient-reported outcomes. METHOD: 657 CAD patients (age = 66.39 ± 10.6; 79% men) completed multiple self-report questionnaires focusing on demographics, negative affectivity and social inhibition (DS14), neuroticism and extraversion (EPQ), resilience (DRS-15), and coping styles (CISS) after undergoing percutaneous coronary intervention...
April 18, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29701041/-acupuncture-combined-with-femoral-nerve-block-for-postoperative-analgesia-after-total-knee-arthroplasty-and-functional-rehabilitation-a-randomized-controlled-trial
#16
Yonghui Zhang, Lin Zhang, Min Lu
OBJECTIVE: To observe the therapeutic effects on the postoperative analgesia after total knee arthroplasty (TKA) and functional rehabilitation with acupuncture at the distal points along the affected meridians and femoral nerve block. METHODS: A total of 60 patients with knee prosthesis were collected and randomized into an observation group and a control group, 30 cases in each one. All of the patients received the femoral nerve block before operation. The analgesia pump was used for analgesia after operation and TKA postoperative rehabilitation was adopted...
March 12, 2018: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
https://www.readbyqxmd.com/read/29686256/passive-limb-movement-intervals-results-in-repeated-hyperemic-responses-in-those-with-paraplegia
#17
Keith J Burns, Brandon S Pollock, Jon Stavres, Martin Kilbane, Amber Brochetti, John McDaniel
STUDY DESIGN: Repeated measures. OBJECTIVES: Reports suggest passive limb movement (PLM) could be used as a therapy to increase blood flow and tissue perfusion in the paralyzed lower limbs of those with spinal cord injuries. However, the hyperemic response to PLM appears to be transient, lasting only 30-45 s despite continued limb movement. The purpose of this investigation was to determine whether the hyperemic response is repeatable across multiple short bouts of passive limb movement...
April 23, 2018: Spinal Cord
https://www.readbyqxmd.com/read/29681928/recovery-of-the-20-hz-rebound-to-tactile-and-proprioceptive-stimulation-after-stroke
#18
Eeva Parkkonen, Kristina Laaksonen, Lauri Parkkonen, Nina Forss
Sensorimotor integration is closely linked to changes in motor-cortical excitability, observable in the modulation of the 20 Hz rhythm. After somatosensory stimulation, the rhythm transiently increases as a rebound that reflects motor-cortex inhibition. Stroke-induced alterations in afferent input likely affect motor-cortex excitability and motor recovery. To study the role of somatosensory afferents in motor-cortex excitability after stroke, we employed magnetoencephalographic recordings (MEG) at 1-7 days, one month, and 12 months in 23 patients with stroke in the middle cerebral artery territory and 22 healthy controls...
2018: Neural Plasticity
https://www.readbyqxmd.com/read/29675510/isolated-subscapularis-tendon-tear-in-a-skeletally-immature-soccer-player
#19
Paolo Avanzi, Luca Dei Giudici, Roberto Giovarruscio, Antonio Gigante, Claudio Zorzi
Subscapularis injury in adolescents, usually associated to an avulsion fracture of the lesser humeral tuberosity, accounts for less than 2% of all fractures of the proximal humerus. Isolated tears of the subscapularis tendon without a history of dislocation and associated avulsion fractures are an even rarer occurrence, and treatment is controversial. This article describes a rare case of a 12-year-old suffering from an isolated subscapularis tear and discusses its management. The patient was evaluated at presentation, and at 1 to 2...
March 2018: Joints
https://www.readbyqxmd.com/read/29667537/parasympathetic-activity-delayed-after-self-paced-exercise
#20
Lucas Rosiello Trojbicz, Mayara Vieira Damasceno, Leonardo Alves Pasqua, Arthur Fernandes Gáspari, Adriano Eduardo Lima-Silva, Rômulo Bertuzzi
The main purpose of this study was to compare the effect of the constant load and self-paced exercise with similar total work on autonomic control after endurance exercise. Ten physically active men were submitted to (i) a maximal incremental exercise test, (ii) a 4-km cycling time trial (4-km TT), and (iii) a constant workload test with identical total external work performed at 4-km TT. Gas exchange was measured throughout the tests, while blood lactate, heart rate, and heart rate variability (HRV) were measured during the passive recovery...
April 18, 2018: European Journal of Sport Science
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