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https://www.readbyqxmd.com/read/29667543/assessment-of-parents-guardians-initial-comprehension-and-1-day-recall-of-elements-of-informed-consent-within-a-mozambican-study-of-pediatric-bacteremia
#1
Ezequiel B Ossemane, Troy D Moon, Jahit Sacarlal, Esperança Sevene, Darlene Kenga, Wu Gong, Elizabeth Heitman
Participants' understanding of key elements of a research protocol is essential to their ethical enrollment in the study. Ongoing participation should be based on continued comprehension and consent, which presumes a high degree of recall. Many obstacles can prevent full understanding of information about the research protocol. This study's aim was to evaluate the comprehension and 1-day recall of the elements of informed consent by the parents/guardians of children enrolled in a clinical study in Mozambique...
April 1, 2018: Journal of Empirical Research on Human Research Ethics: JERHRE
https://www.readbyqxmd.com/read/29667429/quadriceps-function-knee-pain-and-self-reported-outcomes-in-patients-with-anterior-cruciate-ligament-reconstruction
#2
Adam S Lepley, Brian Pietrosimone, Marc L Cormier
CONTEXT:   Interactions among muscle strength, pain, and self-reported outcomes in patients with anterior cruciate ligament reconstruction (ACLR) are not well understood. Clarifying these interactions is of clinical importance because improving physical and psychological function is thought to optimize outcomes after ACLR. OBJECTIVE:   To examine the relationships among neuromuscular quadriceps function, pain, self-reported knee function, readiness to return to activity, and emotional response to injury both before and after ACLR...
April 18, 2018: Journal of Athletic Training
https://www.readbyqxmd.com/read/29666933/-pain-relief-during-and-after-surgical-procedures-results-of-an-austria-wide-patient-survey-on-postoperative-pain-and-perioperative-pain-management
#3
W Jaksch, R Likar, U Frohner, F Herbst
BACKGROUND: Pain after surgery, especially on the first postoperative day, results in longer hospital stays, increased complication rates and may also cause a higher risk of pain chronification. However, the expected intensity of pain is often misjudged and therefore not adequately treated. METHODOLOGY: An Austria-wide patient survey on the pain situation on the first postoperative day and on the quality of perioperative pain management was carried out on a voluntary and anonymous basis...
April 17, 2018: Der Schmerz
https://www.readbyqxmd.com/read/29666131/doctors-on-the-move-a-european-case-study-on-the-key-characteristics-of-national-recertification-systems
#4
Carolin Sehlbach, Marjan J Govaerts, Sharon Mitchell, Gernot G U Rohde, Frank W J M Smeenk, Erik W Driessen
OBJECTIVES: With increased cross-border movement, ensuring safe and high-quality healthcare has gained primacy. The purpose of recertification is to ensure quality of care through periodically attesting doctors' professional proficiency in their field. Professional migration and facilitated cross-border recognition of qualifications, however, make us question the fitness of national policies for safeguarding patient care and the international accountability of doctors. DESIGN AND SETTING: We performed document analyses and conducted 19 semistructured interviews to identify and describe key characteristics and effective components of 10 different European recertification systems, each representing one case (collective case study)...
April 17, 2018: BMJ Open
https://www.readbyqxmd.com/read/29665785/new-types-of-drug-use-and-risks-of-drug-use-among-men-who-have-sex-with-men-a-cross-sectional-study-in-hangzhou-china
#5
Lin He, Xiaohong Pan, Ning Wang, Jiezhe Yang, Jun Jiang, Yan Luo, Xingliang Zhang, Xiting Li
BACKGROUND: The use of new types of drugs has become more common among men who have sex with men (MSM). The aim of this study was to describe the patterns of the use of new types of drugs, such as methamphetamine, ketamine, ecstasy, and rush poppers, and to examine the factors associated with drug use and HIV infection among MSM in Hangzhou, China. METHODS: This cross-sectional study was conducted between August 2015 and April 2016. We used snowball sampling to recruit MSM; participants were recruited from voluntary counseling and testing centers, baths, bars, Blued (an app for the gay community), QQ groups, clubs, and other types of venues...
April 17, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29665622/existing-regulatory-approaches-to-reducing-exposures-to-chemical-and-product-based-risk-and-their-applicability-to-diet-related-chronic-disease
#6
Deborah A Cohen, Debra S Knopman
We aimed to identify and categorize the types of policies that have been adopted to protect Americans from harmful exposures that could also be relevant for addressing diet-related chronic diseases. This article examines and categorizes the rationales behind government regulation. Our interest in the historical analysis is to inform judgments about how best to address newly emergent risks involving diet-related chronic disease within existing regulatory and information-based frameworks. We assessed exemplars of regulation with respect to harmful exposures from air, water, and food, as well as regulations that are intended to modify voluntary behaviors...
April 17, 2018: Risk Analysis: An Official Publication of the Society for Risk Analysis
https://www.readbyqxmd.com/read/29665166/silencing-synaptic-microrna-411-reduces-voluntary-alcohol-consumption-in-mice
#7
Dana Most, Nihal A Salem, Gayatri R Tiwari, Yuri A Blednov, R Dayne Mayfield, R Adron Harris
Chronic alcohol consumption alters the levels of microRNAs and mRNAs in the brain, but the specific microRNAs and processes that target mRNAs to affect cellular function and behavior are not known. We examined the in vivo manipulation of previously identified alcohol-responsive microRNAs as potential targets to reduce alcohol consumption. Silencing of miR-411 by infusing antagomiR-411 into the prefrontal cortex of female C57BL/6J mice reduced alcohol consumption and preference, without altering total fluid consumption, saccharin consumption, or anxiety-related behaviors...
April 17, 2018: Addiction Biology
https://www.readbyqxmd.com/read/29665013/planhab-hypoxia-does-not-worsen-the-impairment-of-skeletal-muscle-oxidative-function-induced-by-bed-rest-alone
#8
Desy Salvadego, Michail E Keramidas, Roger Kölegård, Lorenza Brocca, Stefano Lazzer, Irene Mavelli, Jörn Rittweger, Ola Eiken, Igor B Mekjavic, Bruno Grassi
KEY POINTS: Superposition of hypoxia on 21 day bed rest did not worsen the impairment of skeletal muscle oxidative function induced by bed rest alone. A significant impairment of maximal oxidative performance was identified downstream of cardiovascular O2 delivery, involving both the intramuscular matching between O2 supply and utilization and mitochondrial respiration. These chronic adaptations appear to be relevant in terms of exposure to spaceflights and reduced gravity habitats (Moon or Mars), as characterized by low gravity and hypoxia, in patients with chronic diseases characterized by hypomobility/immobility and hypoxia, as well as in ageing...
April 17, 2018: Journal of Physiology
https://www.readbyqxmd.com/read/29664313/voluntary-wheel-running-induces-exercise-seeking-behavior-in-male-rats-a-behavioral-study
#9
Mojtaba Naghshvarian, Mohammad-Reza Zarrindast, Seyedeh Fatemeh Sajjadi
BACKGROUND: Research evidence shows that exercise is associated with positive physical and mental health. Moreover, exercise and wheel running in rats activate overlapping neural systems and reward system. The most commonly used models for the study of rewarding and aversive effects of exercise involve using treadmill and wheel running paradigms in mice or rats. The purpose of our experiment was to study the influence of continuous voluntary exercise on exercise-seeking behavior. METHODS: In this experimental study, we used 24 adult male Sprague-Dawley rats weighing 275-300 g on average...
December 1, 2017: Archives of Iranian Medicine
https://www.readbyqxmd.com/read/29663505/global-and-regional-left-ventricular-circumferential-strain-during-incremental-cycling-and-isometric-knee-extension-exercise
#10
Alexander Beaumont, Nicholas Sculthorpe, John Hough, Viswanath Unnithan, Joanna Richards
BACKGROUND: The objective of this study was to investigate left ventricular (LV) circumferential strain responses to incremental cycling and isometric knee extension exercises. METHODS: Twenty-six healthy male participants (age = 30 ± 6 years) were used to study LV global (GCS) and regional circumferential strain at the apex (ACS) and base (BCS) during incremental cycling at 30% and 60% work rate maximum (Wmax ) and short-duration (15 seconds contractions) isometric knee extensions at 40% and 75% maximum voluntary contraction (MVC) using two-dimensional speckle tracking echocardiography...
April 16, 2018: Echocardiography
https://www.readbyqxmd.com/read/29663488/delayed-onset-muscle-soreness-in-human-masticatory-muscles-increases-inhibitory-jaw-reflex-responses
#11
Michail Koutris, Kemal S Türker, Maurits K A van Selms, Frank Lobbezoo
INTRODUCTION: The effects of masticatory muscles' overloading on jaw-motor control are not yet fully clarified. Therefore, it was tested whether eccentric and concentric exercises of the human masticatory muscles would influence inhibitory jaw-reflex responses. METHODS: 11 participants (6 males, 5 females) performed 6, 5-min bouts of eccentric-concentric contractions. Before, immediately after, 24 hours, 48 hours, and one week afterwards, visual analogue scale (VAS) scores for jaw-muscle fatigue and pain, maximum voluntary bite force (MVBF), and inhibitory jaw reflexes were recorded...
April 16, 2018: Journal of Oral Rehabilitation
https://www.readbyqxmd.com/read/29663024/neural-motor-control-differs-between-bimanual-common-goal-vs-bimanual-dual-goal-tasks
#12
Wan-Wen Liao, Jill Whitall, Joseph E Barton, Sandy McCombe Waller
Coordinating bimanual movements is essential for everyday activities. Two common types of bimanual tasks are common goal, where two arms share a united goal, and dual goal, which involves independent goals for each arm. Here, we examine how the neural control mechanisms differ between these two types of bimanual tasks. Ten non-disabled individuals performed isometric force tasks of the elbow at 10% of their maximal voluntary force in both bimanual common and dual goals as well as unimanual conditions. Using transcranial magnetic stimulation, we concurrently examined the intracortical inhibitory modulation (short-interval intracortical inhibition, SICI) as well as the interlimb coordination strategies utilized between common- vs...
April 16, 2018: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
https://www.readbyqxmd.com/read/29662945/metabotropic-glutamate-receptor-2-3-mglur2-3-activation-suppresses-trpv1-sensitization-in-mouse-but-not-human-sensory-neurons
#13
Tayler D Sheahan, Manouela V Valtcheva, Lisa A McIlvried, Melanie Y Pullen, David A A Baranger, Robert W Gereau
The use of human tissue to validate putative analgesic targets identified in rodents is a promising strategy for improving the historically poor translational record of preclinical pain research. We recently demonstrated that in mouse and human sensory neurons, agonists for metabotropic glutamate receptors 2 and 3 (mGluR2/3) reduce membrane hyperexcitability produced by the inflammatory mediator prostaglandin E2 (PGE2 ). Previous rodent studies indicate that mGluR2/3 can also reduce peripheral sensitization by suppressing inflammation-induced sensitization of TRPV1...
March 2018: ENeuro
https://www.readbyqxmd.com/read/29662895/heme-oxygenase-1-activity-as-a-correlate-to-exercise-mediated-amelioration-of-cognitive-decline-and-neuropathological-alterations-in-an-aging-rat-model-of-dementia
#14
Andrea Kurucz, Mariann Bombicz, Rita Kiss, Dániel Priksz, Balázs Varga, Tibor Hortobágyi, György Trencsényi, Renáta Szabó, Anikó Pósa, Rudolf Gesztelyi, Zoltán Szilvássy, Béla Juhász
Alzheimer's disease (AD) is a neurodegenerative disorder with cognitive impairment. Physical exercise has long been proven to be beneficial in the disorder. The present study was designed to examine the effect of voluntary exercise on spatial memory, imaging, and pathological abnormalities. Particular focus has been given to the role of heme oxygenase-1 (HO-1)-an important cellular cytoprotectant in preserving mental acuity-using an aging rat model of dementia. Male and female Wistar rats were segregated into six groups-namely, (i) aged sedentary (control) females (ASF, n = 8); (ii) aged sedentary (control) males (ASM, n = 8); (iii) aged running females (ARF, n = 8); (iv) aged running males (ARM, n = 8); (v) young control females (YCF, n = 8); and (vi) young control males (YCM, n = 8)...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29661752/a-novel-information-retrieval-tool-to-find-hospital-care-team-members-development-and-usability-study
#15
Kyle Morawski, Craig Monsen, Sukhjit Takhar, Adam Landman
BACKGROUND: Hospital communication among members of a patient's care team is a central part of clinical workflow and consumes a large amount of a health care provider's time. Oftentimes the complexity of hospital care leads to difficulty in finding the appropriate contact, which can lead to inefficiencies and frustration. Squire is a Web-based information retrieval app created to improve the speed and efficiency in reaching the appropriate team member during the care of a hospitalized patient...
April 16, 2018: JMIR Human Factors
https://www.readbyqxmd.com/read/29661237/evaluating-the-effects-of-delivering-integrated-kinesthetic-and-tactile-cues-to-individuals-with-unilateral-hemiparetic-stroke-during-overground-walking
#16
Muhammad Raheel Afzal, Sanghun Pyo, Min-Kyun Oh, Young Sook Park, Jungwon Yoon
BACKGROUND: Integration of kinesthetic and tactile cues for application to post-stroke gait rehabilitation is a novel concept which needs to be explored. The combined provision of haptic cues may result in collective improvement of gait parameters such as symmetry, balance and muscle activation patterns. Our proposed integrated cue system can offer a cost-effective and voluntary gait training experience for rehabilitation of subjects with unilateral hemiparetic stroke. METHODS: Ten post-stroke ambulatory subjects participated in a 10 m walking trial while utilizing the haptic cues (either alone or integrated application), at their preferred and increased gait speeds...
April 16, 2018: Journal of Neuroengineering and Rehabilitation
https://www.readbyqxmd.com/read/29660812/tremor-severity-in-parkinson-s-disease-and-cortical-changes-of-areas-controlling-movement-sequencing-a-preliminary-study
#17
Julián Benito-León, J Ignacio Serrano, Elan D Louis, Ales Holobar, Juan P Romero, P Povalej-Bržan, Félix Bermejo-Pareja, M Dolores Del Castillo, Ignacio J Posada, Eduardo Rocon
There remains much to learn about the changes in cortical anatomy that are associated with tremor severity in Parkinson's disease (PD). For this reason, we used a combination of structural neuroimaging to measure cortical thickness and neurophysiological studies to analyze whether PD tremor was associated with cortex integrity. Magnetic resonance imaging and neurophysiological assessment were performed in 13 nondemented PD patients (9 women, 69.2%) with a clearly tremor-dominant phenotype. Cortical reconstruction and volumetric segmentation were performed with the Freesurfer image analysis software...
April 16, 2018: Journal of Neuroscience Research
https://www.readbyqxmd.com/read/29659943/cooperation-process-between-a-local-government-and-experts-in-official-voluntary-decontamination-of-environmental-radioactivity
#18
Takeshi Iimoto, Hirofumi Fujii, Seiichi Someya, Hajime Matsuzawa, Yukihide Yanagawa, Kiyoshi Kunii
Kashiwa city, inside the Tokyo metropolitan area and located ~200 km south of the Fukushima Dai-ichi Nuclear Power Plant, received a raised environmental ambient radiation dose due to the disaster relative to the rest of area. In this paper, the challenging process of the official voluntary decontamination activity in Kashiwa city, Chiba prefecture, which was carried out with strong cooperation between a local government and experts, is described and reviewed in terms of the effectiveness of the radiation protection...
April 6, 2018: Journal of Radiation Research
https://www.readbyqxmd.com/read/29659626/influence-of-respiratory-mechanics-and-drive-on-genioglossus-movement-under-ultrasound-imaging
#19
Benjamin C H Kwan, Rachel A McBain, Billy L Luu, Jane E Butler, Lynne E Bilston, Simon C Gandevia
METHODS: Twenty healthy subjects (10 males, age 28±5 years [mean ± SD]) lay supine, awake, with the head in a neutral position. Ventilation was monitored with inductance bands. Real-time B-mode ultrasound movies were analysed. We measured genioglossus motion (i) during spontaneous breathing, voluntary targeted breathing (normal tidal volume Vt), and voluntary hyperpnoea (at 1.5Vt and 2 Vt); (ii) during inspiratory flow resistive loading; (iii) with changes in end-expiratory lung volume (EELV)...
2018: PloS One
https://www.readbyqxmd.com/read/29659351/control-of-voluntary-and-optogenetically-perturbed-locomotion-by-spike-rate-and-timing-of-neurons-of-the-mouse-cerebellar-nuclei
#20
Rashmi Sarnaik, Indira M Raman
Neurons of the cerebellar nuclei (CbN), which generate cerebellar output, are inhibited by Purkinje cells. With extracellular recordings during voluntary locomotion in head-fixed mice, we tested how the rate and coherence of inhibition influence CbN cell firing and well-practiced movements. Firing rates of Purkinje and CbN cells were modulated systematically through the stride cycle (~200-300 ms). Optogenetically stimulating ChR2-expressing Purkinje cells with light steps or trains evoked either asynchronous or synchronous inhibition of CbN cells...
April 16, 2018: ELife
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