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Outcome and preterm infant

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https://www.readbyqxmd.com/read/29777555/impact-of-nicu-oral-feeding-on-neuropsychomotor-outcomes-at-9-months-of-corrected-age-in-chinese-low-birth-weight-preterm-infants-a-retrospective-study
#1
Wenwen Ding, Lijin Zhao, Nan Sheng, Jiali Ma, Ying Zhang
AIMS AND OBJECTIVES: To examine the changes in neuropsychomotor development and investigate the effect of feeding progression in Neonatal Intensive Care Unit (NICU) on neuropsychomotor outcomes in low-birth-weight preterm infants within 9 months of corrected age. BACKGROUND: Low-birth-weight (LBW) preterm infants (<37 weeks of gestation and birth weight < 2500 g) are at a high risk for neuropsychomotor development delay. Therefore, exploring NICU practices related to neuropsychomotor development is important...
May 18, 2018: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/29776928/enrichment-of-clinically-relevant-organisms-in-spontaneous-preterm-delivered-placenta-and-reagent-contamination-across-all-clinical-groups-in-a-large-uk-pregnancy-cohort
#2
Lydia J Leon, Ronan Doyle, Ernest Diez-Benavente, Taane G Clark, Nigel Klein, Philip Stanier, Gudrun E Moore
In this study differences in the placental microbiota of term and preterm deliveries from a large UK pregnancy cohort were studied using 16S targeted amplicon sequencing. The impact of contamination from DNA extraction, PCR reagents, as well as those from delivery itself were also examined. A total of 400 placental samples from 256 singleton pregnancies were analysed and differences investigated between spontaneous preterm, non-spontaneous preterm, and term delivered placenta. DNA from recently delivered placenta was extracted, and screening for bacterial DNA was carried out using targeted sequencing of the 16S rRNA gene on the Illumina MiSeq platform...
May 18, 2018: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/29776801/determinants-of-a-good-perinatal-outcome-in-588-pregnancies-in-women-with-type-1-diabetes
#3
J Lepercq, C Le Ray, C Godefroy, L Pelage, D Dubois-Laforgue, J Timsit
AIM: This study assessed pregnancy outcomes in women with type 1 diabetes (T1D) over the last 15 years and identified modifiable factors associated with good perinatal outcomes. METHODS: Pregnancy outcomes were prospectively assessed in this cohort study of 588 singleton pregnancies (441 women) managed by standardized care from 2000 to 2014. A good perinatal outcome was defined as the uncomplicated delivery of a normally formed, non-macrosomic, full-term infant with no neonatal morbidity...
May 8, 2018: Diabetes & Metabolism
https://www.readbyqxmd.com/read/29772833/the-effect-of-increasing-the-protein-content-of-human-milk-fortifier-to-1-8-g-100-ml-on-growth-in-preterm-infants-a-randomised-controlled-trial
#4
Jessica Reid, Maria Makrides, Andrew J McPhee, Michael J Stark, Jacqueline Miller, Carmel T Collins
The aim of this study was to assess the effect of feeding high protein human milk fortifier (HMF) on growth in preterm infants. In this single-centre randomised trial, 60 infants born 28⁻32 weeks' gestation were randomised to receive a higher protein HMF providing 1.8 g protein ( n = 31) or standard HMF providing 1 g protein per 100 mL expressed breast milk (EBM) ( n = 29). The primary outcome was rate of weight gain. Baseline characteristics were similar between groups. There was no difference between high and standard HMF groups for weight gain (mean difference (MD) -14 g/week; 95% CI -32, 4; p = 0...
May 17, 2018: Nutrients
https://www.readbyqxmd.com/read/29769056/report-on-an-international-workshop-on-kangaroo-mother-care-lessons-learned-and-a-vision-for-the-future
#5
Adriano Cattaneo, Adidja Amani, Nathalie Charpak, Socorro De Leon-Mendoza, Sarah Moxon, Somashekhar Nimbalkar, Giorgio Tamburlini, Julieta Villegas, Anne-Marie Bergh
BACKGROUND: Globally, complications of prematurity are the leading cause of death in children under five. Preterm infants who survive their first month of life are at greater risk for various diseases and impairments in infancy, childhood and later life, representing a heavy social and economic burden for families, communities and health and social systems. Kangaroo mother care (KMC) is recommended as a beneficial and effective intervention for improving short- and long-term preterm birth outcomes in low- and high-income settings...
May 16, 2018: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29768986/the-effect-of-prepregnancy-body-mass-index-on-birth-weight-preterm-birth-cesarean-section-and-preeclampsia-in-pregnant-women
#6
Maryam Mohammadi, Saman Maroufizadeh, Reza Omani-Samani, Amir Almasi-Hashiani, Payam Amini
OBJECTIVE: The objective of this study is to determine the impact of maternal prepregnancy BMI on birth weight, preterm birth, cesarean section, and preeclampsia among pregnant women delivering singleton life birth. METHODS: A cross-sectional study of 4397 women who gave singleton birth in Tehran, Iran from 6 to 21 July 2015, was conducted. Women were categorized into four groups: underweight (BMI < 18.5 kg/m2 ), normal (BMI 18.5-25 kg/m2 ), overweight (BMI 25-30 kg/m2 ) and obese (BMI >30 kg/m2 ), and their obstetric and infant outcomes were analyzed using both univariate and multivariate logistic regression...
May 17, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29768941/bilirubin-and-oxidative-stress-in-term-and-preterm-infants
#7
Carlo Dani, Chiara Poggi, Simone Pratesi
Hyperbilirubinemia is the most frequent clinical problem neonatologists must deal with during the newborn period. It has been suggested that bilirubin is involved in the balance between antioxidant and pro-oxidant agents due to its antioxidant properties. However, the relevance of these effects in vivo in term and preterm infants is still debated. We performed a literature review of studies that investigated the association between total serum bilirubin (TSB) and oxidative stress in newborn infants. We found that studies in term infants give contradictory results, while studies in preterm infants suggest that the TSB increase is associated with an oxidative stress increase due to concurrent factors other than bilirubin level, such as heme oxygenase (HO) activity...
May 16, 2018: Free Radical Research
https://www.readbyqxmd.com/read/29767630/characterization-of-cardiorespiratory-phase-synchronization-and-directionality-in-late-premature-and-full-term-infants
#8
Maristella Lucchini, Nicolo Pini, William P Fifer, Nina Burtchen, Maria G Signorini
OBJECTIVE: Though the mutual influence of cardiovascular and respiratory rhythms in healthy newborns has been documented, its full characterization is still pending. In general, activity of many physiological subsystems has a well expressed rhythmic character, and often an interdependency between physiological rhythms emerges early in development. Traditional methods of data analysis only address the quantification of the strength of subsystem interactions. In this work, we will investigate system interrelationships in terms of possible presence of causal or directional interplays...
May 16, 2018: Physiological Measurement
https://www.readbyqxmd.com/read/29767620/quantile-regression-analysis-of-language-and-interpregnancy-interval-in-quebec-canada
#9
Nathalie Auger, Lucien Lemieux, Marianne Bilodeau-Bertrand, Amadou Diogo Barry, André Costopoulos
INTRODUCTION: Short and long interpregnancy intervals are associated with adverse perinatal outcomes such as miscarriage and preterm delivery, but cultural differences in interpregnancy intervals are understudied. Identifying cultural inequality in interpregnancy intervals is necessary to improve maternal-child outcomes. We assessed interpregnancy intervals for Anglophones and Francophones in Quebec. METHODS: We obtained birth records for all infants born in Quebec, 1989-2011...
May 2018: Health Promotion and Chronic Disease Prevention in Canada
https://www.readbyqxmd.com/read/29762633/using-a-mixture-of-bivariate-regression-model-to-explore-heterogeneity-of-effects-of-use-of-inhaled-corticosteroids-on-gestational-age-and-birthweight-among-pregnant-women-with-asthma
#10
Mariia Samoilenko, Lucie Blais, Isabelle Boucoiran, Geneviève Lefebvre
Asthma is a heterogeneous disease, and responses to asthma medications vary noticeably among patients. A substantively oriented objective of this study was to explore the potential heterogeneous effects of maternal inhaled corticosteroids (ICS) exposure on gestational age (GA) at delivery and birthweight (BW) using a cohort of 6,197 pregnancies from women with asthma (Quebec, Canada, 1998-2008). A methodologically oriented objective was to comprehensively describe the application of a Bayesian two-component mixture of bivariate regressions to address this issue and estimate the effects of ICS on GA and BW jointly...
May 14, 2018: American Journal of Epidemiology
https://www.readbyqxmd.com/read/29762175/pregnancy-outcomes-and-infant-growth-among-babies-with-in-utero-exposure-to-tenofovir-based-pre-exposure-prophylaxis-for-hiv-prevention
#11
Renee Heffron, Nelly Mugo, Ting Hong, Connie Celum, Mark A Marzinke, Kenneth Ngure, Stephen Asiimwe, Elly Katabira, Elizabeth Bukusi, Josephine Odoyo, Edna Tindimwebwa, Nulu Bulya, Jared M Baeten
BACKGROUND: Global guidelines recommend pre-exposure prophylaxis (PrEP) use by women at risk for HIV, including during pregnancy, a period with heightened HIV risk. However, data to support safety of PrEP use during pregnancy are limited, particularly from women using PrEP throughout pregnancy. METHODS: In an open-label delivery study of PrEP integrated with ART for high risk HIV serodiscordant couples in Kenya and Uganda (the Partners Demonstration Project), women who became pregnant while using PrEP were offered the option to continue PrEP throughout pregnancy...
May 11, 2018: AIDS
https://www.readbyqxmd.com/read/29758177/the-efficacy-of-antenatal-steroid-therapy-is-dependent-on-the-duration-of-low-concentration-fetal-exposure-evidence-from-a-sheep-model-of-pregnancy
#12
Matthew W Kemp, Masatoshi Saito, Haruo Usuda, Shimpei Watanabe, Shinichi Sato, Takushi Hanita, Yusaku Kumagai, Timothy J Molloy, Michael Clarke, Peter J Eddershaw, Gabrielle C Musk, Augusto Schmidt, Demelza Ireland, Lucy Furfaro, Matthew S Payne, John P Newnham, Alan H Jobe
OBJECTIVE: Antenatal corticosteroids (ANS) are among the most important and widely used interventions to improve outcomes for preterm infants. ANS dosing regimens remain un-optimized and without maternal weight-adjusted dosing. We, and others, have hypothesised that once a low concentration of materno-fetal steroid exposure is achieved and maintained, the duration of the steroid exposure determines treatment efficacy. Using a sheep model of pregnancy, we tested the relationship between steroid dose, and duration of exposure, and treatment efficacy...
May 9, 2018: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29758096/low-maternal-serum-concentrations-of-mannose-binding-lectin-mbl-are-associated-with-the-risk-of-shorter-duration-of-pregnancy-and-lower-birth-weight
#13
Michal Koucký, Karin Malíčková, Helena Kopřivová, Tereza Cindrová-Davies, Hana Hrbáčková, Andrej Černý, Patrik Šimják, Antonín Pařízek, Tomáš Zima
BACKROUND: Chronic inflammation has been implicated as the underlying mechanism responsible for the pathophysiology of preterm labor. Mannose-bindig lectin (MBL) plays a central role in the innate immune response and is thus an important component of the first line of defense. The aim of this study was to investigate whether serum concentrations of MBL correlated with the incidence of preterm birth and low birth weight in a cohort of women with signs of threatened preterm birth. METHODS: A cohort of 60 patients who presented with regular contractions and/or short cervix (group A) between 24 to 32 weeks of gestation and 20 healthy controls (group B) who had no pregnancy complications and delivered at term were recruited into a prospective study...
May 14, 2018: Scandinavian Journal of Immunology
https://www.readbyqxmd.com/read/29756708/hypercalcemia-and-hypophosphatemia-among-preterm-infants-receiving-aggressive-parenteral-nutrition
#14
Pablo H Brener Dik, María F Galletti, Leticia T Bacigalupo, Silvia Fernández Jonusas, Gonzalo L Mariani
INTRODUCTION: Aggressive parenteral nutrition is the standard of care among very-low-birth weight preterm infants. However, in recent studies, its impact on short-term outcomes, has been evaluated. The objective was to compare the prevalence of hypercalcemia and hypophosphatemia among preterm infants receiving aggressive or standard parenteral nutrition. METHODS: Observational, retrospective study comparing a group of preterm infants weighing less than 1250 grams who received aggressive parenteral nutrition with a historical control group...
June 1, 2018: Archivos Argentinos de Pediatría
https://www.readbyqxmd.com/read/29756373/do-feeding-practices-during-transfusion-influence-the-risk-of-developing-necrotising-enterocolitis-in-preterm-infants
#15
Cathie Hilditch, Amy Keir
Our evidence-based review set out to answer the clinical question 'In a preterm infant (patient) with anaemia of prematurity, do feeding practices (intervention) during blood transfusion reduce the risk of developing transfusion-associated necrotising enterocolitis (outcome)'? We found limited evidence that withholding feeding during red blood cell transfusion in preterm infants may reduce the risk of development of transfusion-associated necrotising enterocolitis. As clinical equipoise seemingly exists, it seems reasonable for individual units to make their own decisions regarding whether to withhold or continue enteral feeds during red blood cell transfusion until further evidence is available...
May 2018: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/29755962/acceptability-of-bedside-resuscitation-with-intact-umbilical-cord-to-clinicians-and-patients-families-in-the-united-states
#16
Anup C Katheria, Samuel R Sorkhi, Kasim Hassen, Arij Faksh, Zahra Ghorishi, Debra Poeltler
Background: While delayed umbilical cord clamping in preterm infants has shown to improve long-term neurological outcomes, infants who are thought to need resuscitation do not receive delayed cord clamping even though they may benefit the most. A mobile resuscitation platform allows infants to be resuscitated at the mother's bedside with the cord intact. The newborn is supplied with placental blood during the resuscitation in view of the mother. The objective of the study is to assess the usability and acceptability of mobile resuscitation platform, LifeStart trolley, among the infants' parents and perinatal providers...
2018: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/29753727/gender-dependent-changes-in-physical-development-bdnf-content-and-gsh-redox-system-in-a-model-of-acute-neonatal-hypoxia-in-rats
#17
Iu A Sukhanova, E A Sebentsova, D D Khukhareva, D M Manchenko, N Yu Glazova, P A Vishnyakova, L S Inozemtseva, O V Dolotov, M Y Vysokikh, N G Levitskaya
Perinatal hypoxia-ischaemia is one of the leading factors that negatively influence the development of the central nervous system. Our aim was to investigate the effects of sex on the outcomes of acute neonatal hypoxia (ANH) in rat pups. Male and female Wistar rats were exposed to a hypoxic condition (8% oxygen for 120 min) at postnatal day 2 (P2). Immediately after ANH an increase in HIF1-α gene expression was observed in the rat brains, independently of sex. Brain-derived neurotrophic factor (BDNF) and glutathione peroxidase-4 gene expression was increased in female animals only...
May 10, 2018: Behavioural Brain Research
https://www.readbyqxmd.com/read/29752125/persistent-and-progressive-long-term-lung-disease-in-survivors-of-preterm-birth
#18
REVIEW
Rhea Urs, Sailesh Kotecha, Graham L Hall, Shannon J Simpson
Preterm birth accounts for approximately 11% of births globally, with rates increasing across many countries. Concurrent advances in neonatal care have led to increased survival of infants of lower gestational age (GA). However, infants born <32 weeks of GA experience adverse respiratory outcomes, manifesting with increased respiratory symptoms, hospitalisation and health care utilisation into early childhood. The development of bronchopulmonary dysplasia (BPD) - the chronic lung disease of prematurity - further increases the risk of poor respiratory outcomes throughout childhood, into adolescence and adulthood...
April 13, 2018: Paediatric Respiratory Reviews
https://www.readbyqxmd.com/read/29751529/the-use-and-safety-of-tnf-inhibitors-during-pregnancy-in-women-with-psoriasis-a-review
#19
REVIEW
Cæcilie Bachdal Johansen, Espen Jimenez-Solem, Ann Haerskjold, Freja Lærke Sand, Simon Francis Thomsen
Psoriasis is a chronic immune-mediated inflammatory disease affecting women of childbearing potential. Biologic agents, notably Tumor Necrosis Factor inhibitors (TNFi), are the only current non-contraindicated systemic treatment option during pregnancy. TNFi comprised of complete immunoglobulin G (IgG) antibodies antibodies (adalimumab, golimumab, and infliximab) actively cross the placenta from the second trimester and are detectable in the child up to one year postpartum. Data on safety of TNFi are conflicting; however a trend towards drug-specific harm has been reported, with increased risk of congenital malformations and preterm birth...
May 3, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29750954/neonatal-and-fetal-growth-charts-to-identify-preterm-infants-less-than-30-weeks-gestation-at-risk-of-adverse-outcomes
#20
Nansi S Boghossian, Marco Geraci, Erika M Edwards, Jeffrey D Horbar
BACKGROUND: It is unclear whether a neonatal or a fetal growth standard is a better predictor of adverse in-hospital newborn outcomes. OBJECTIVE: We aimed to evaluate and compare the power of birth weight for gestational age to predict adverse neonatal outcomes using neonatal and fetal growth charts. Gestational age specific birth weight was examined either as a centile score or as a binary indicator for birth weight below the 10th centile (small for gestational age) using three fetal growth charts (National Institute of Child Health and Human Development, World Health Organization, and Intergrowth-21st ) and one neonatal sex-specific birth weight chart...
May 8, 2018: American Journal of Obstetrics and Gynecology
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