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Pain and preterm infant

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https://www.readbyqxmd.com/read/29165703/effects-of-neonatal-pain-and-temperament-on-attention-problems-in-toddlers-born-preterm
#1
Claudia M Gaspardo, Rafaela G M Cassiano, Sofia M A Gracioli, Guilherme C B Furini, Maria Beatriz M Linhares
Objective: To examine the effects of individual characteristics of neonates and neonatal pain-related stress on attention problems and externalizing behavior problems of toddlers born preterm, analyzing the moderating effects of the dispositional traits of temperament. Methods: The sample included 62 toddlers aged 18-36 months and their mothers. The mothers were interviewed using the Child Behavior Checklist 1.5-5 for toddlers' attention and externalizing behavior problems assessment, the Early Childhood Behavior Questionnaire for toddlers' temperament assessment, and the Adult Temperament Questionnaire for their temperament assessment...
November 17, 2017: Journal of Pediatric Psychology
https://www.readbyqxmd.com/read/29163364/telomere-length-in-preterm-infants-a-promising-biomarker-of-early-adversity-and-care-in-the-neonatal-intensive-care-unit
#2
Livio Provenzi, Giunia Scotto di Minico, Roberto Giorda, Rosario Montirosso
Preterm infants present an immature neurobehavioral profile at birth, even in absence of severe brain injuries and perinatal complications. As such, they require a long-lasting hospitalization in the Neonatal Intensive Care Unit (NICU), which is thought to grant at-risk newborns' survival, but still entails a number of physical, painful, and socio-emotional stressors. Hence, preterm birth and NICU stay represent an early adverse experience, which has been linked to detrimental consequences for neurological, neuro-endocrinal, behavioral, and socio-emotional development, as well as to disease later in life...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29150862/randomised-crossover-trial-showed-that-using-breast-milk-or-sucrose-provided-the-same-analgesic-effect-in-preterm-infants-of-at-least-28-weeks
#3
L Collados-Gómez, P Ferrera-Camacho, E Fernandez-Serrano, V Camacho-Vicente, C Flores-Herrero, A M García-Pozo, R Jiménez-García
AIM: Repeated, on-going exposure to pain influences the growth, cognitive and motor functions, behaviour, personality and neurodevelopment of preterm infants. We compared the analgesic effects of expressed breast milk and 24% oral sucrose on preterm neonates during venipuncture. METHODS: This multicentre randomised, non-inferiority, cross-over trial focused on five neonatal university units in Madrid, Spain, from October 2013 to October 2014. It comprised 66 preterm infants born at less than 37 weeks and randomly split into two groups...
November 18, 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/29123341/effect-of-expressed-breast-milk-versus-swaddling-versus-oral-sucrose-administration-on-pain-associated-with-suctioning-in-preterm-neonates-on-assisted-ventilation-a-randomized-controlled-trial
#4
Saumil Desai, Ruchi Nimish Nanavati, Rohit Nathani, Nandkishor Kabra
Objective: The objective of our study was to assess the pain associated with suctioning in preterm neonates on assisted ventilation and comparing the use of expressed breast milk (EBM), sucrose, and swaddling to alleviate pain. Methods: Study design: A randomized controlled clinical trial. Inclusion Criteria: Preterm neonates on assisted ventilation. Exclusion Criteria: Major congenital anomalies and severe encephalopathy...
October 2017: Indian Journal of Palliative Care
https://www.readbyqxmd.com/read/29105147/intravenous-paracetamol-was-associated-with-closure-of-the-ductus-arteriosus-in-extremely-premature-infants
#5
S Juujärvi, T Saarela, M Hallman, O Aikio
AIM: Symptomatic patent ductus arteriosus may lead to serious complications in extremely preterm and extremely low birth weight infants and is often resistant to medication. We evaluated early intravenous paracetamol for pain prevention during respiratory therapy, in an attempt to understand the ductal treatment of such infants. METHODS: Our cohort were 295 extremely preterm or extremely low birth weight infants, born at less than 28 weeks or 1,000g, respectively, who were treated in the neonatal intensive care unit of Oulu University Hospital from 2002-2015, before and after intravenous paracetamol was introduced in June 2009...
November 4, 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/29100198/non-nutritive-sucking-oral-breast-milk-and-facilitated-tucking-relieve-preterm-infant-pain-during-heel-stick-procedures-a-prospective-randomized-controlled-trial
#6
Hsueh-Fang Peng, Ti Yin, Luke Yang, Chi Wang, Yue-Cune Chang, Mei-Jy Jeng, Jen-Jiuan Liaw
BACKGROUND: Preterm infant pain can be relieved by combining non-nutritive sucking (sucking), oral sucrose, and facilitated tucking (tucking), but the pain-relief effects of oral expressed breast milk (breast milk) are ambiguous. AIMS: We compared the effects of combined sucking+ breast milk, sucking+breast milk+tucking, and routine care on preterm infant pain during and after heel-stick procedures. DESIGN: A prospective, randomized controlled trial...
October 8, 2017: International Journal of Nursing Studies
https://www.readbyqxmd.com/read/29060730/estimation-of-respiratory-rate-from-thermal-videos-of-preterm-infants
#7
Carina Barbosa Pereira, Konrad Heimann, Boudewijn Venema, Vladimir Blazek, Michael Czaplik, Steffen Leonhardt
Studies have demonstrated that respiratory rate (RR) is a good predictor of the patient condition as well as an early marker of patient deterioration and physiological distress. However, it is also referred as "the neglected vital parameter". This is mainly due to shortcoming of current monitoring techniques. Moreover, in preterm infants, the removal of adhesive electrodes cause epidermal stripping, skin disruption, and with it pain. This paper proposes a new algorithm for estimation of RR in thermal videos of moderate preterm infants...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/29036213/the-value-of-real-time-continuous-glucose-monitoring-in-premature-infants-of-diabetic-mothers
#8
Hean-Pat Saw, Nai-Wei Yao, Cheng-Di Chiu, Jia-Yuh Chen
To determine the feasibility of using a real-time continuous glucose monitoring system (RTGMS) in intensive care units, our study focus on preterm infants with diabetic mothers owing to their high risk of blood sugar abnormalities. Thirty preterm babies (M = 15 and F = 15; ≤ 36 week gestation age) were studied from within 72 hours of delivery. These babies were admitted to the newborn intensive care and were further categorized into groups based on whether their mothers with or without diabetic mellitus. Blood sugar levels were monitored by both RTGMS and the traditional intermittent arterial line (A-Line) glucose method...
2017: PloS One
https://www.readbyqxmd.com/read/29033995/effect-of-environmental-and-behavioral-interventions-on-pain-intensity-in-preterm-infants-for-heel-prick-blood-sampling-in-the-neonatal-intensive-care-unit
#9
Fatemeh Baharlooei, Maryam Marofi, Zahra Abdeyazdan
BACKGROUND: Recent researches suggest that preterm infants understand pain and stress. Because of the wide range of effects of pain on infants, the present study was conducted on the effect of environmental and behavioral interventions on pain due to heel-prick blood sampling in preterm infants. MATERIALS AND METHODS: A clinical trial was conducted among 32 infants with gestational age of 32-37 weeks in the intervention and control groups. The effects of noise reduction by earplugs, light reduction by blindfolds, reduction of nursing manipulation, and creation of intrauterine position for neonates, 30 minutes before taking blood samples until 30 minutes after it, were measured during the intervention stage...
September 2017: Iranian Journal of Nursing and Midwifery Research
https://www.readbyqxmd.com/read/28981619/cortical-responses-to-alien-odors-in-newborns-an-fnirs-study
#10
Jakob Frie, Marco Bartocci, Hugo Lagercrantz, Pierre Kuhn
Very preterm (VPT) infants are exposed to odors released by healthcare products, triggering the trigeminal and olfactory subsystems. Irritation of the nasal mucosa induces pain in adults. We examined whether preterm and full-term (FT) newborns perceived trigeminal odors at different cortical levels, whether these odors elicit pain, and if oral glucose modulates this pain. We performed 44 recording sessions in newborn (15 VPT infants, 12 VPT infants at term-equivalent age, and 17 FT infants) following exposure to trigeminal/olfactory stimuli from the hospital environment...
August 1, 2017: Cerebral Cortex
https://www.readbyqxmd.com/read/28967603/-the-care-of-extremely-preterm-infants-a-french-view-of-the-swedish-experience
#11
C Casper, P Kuhn
Extreme prematurity, defined as birth occurring before 27 weeks of gestation in Sweden, is managed according to the latest data of the most recent literature, with monitoring of the results through a continuous perinatal registry. National guidelines were issued in 2013. They highlight the importance of infant developmentally supportive and family-centered care focused on the child and the family, nutritional support, pain management, management of ductus arteriosus, and brain damage. However, there remain areas without national consensus including respiratory support management...
November 2017: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://www.readbyqxmd.com/read/28959218/maternal-sensitivity-buffers-the-association-between-slc6a4-methylation-and-socio-emotional-stress-response-in-3-month-old-full-term-but-not-very-preterm-infants
#12
Livio Provenzi, Monica Fumagalli, Roberto Giorda, Francesco Morandi, Ida Sirgiovanni, Uberto Pozzoli, Fabio Mosca, Renato Borgatti, Rosario Montirosso
BACKGROUND: Very preterm (VPT) infants are hospitalized in Neonatal Intensive Care Units (NICUs) and are exposed to life-saving procedures eliciting pain-related stress. Recent research documented that pain-related stress might result in birth-to-discharge increased methylation of serotonin transporter gene (SLC6A4) in VPT infants, leading to poorer stress regulation at 3 months of age in VPT infants compared to their full-term (FT) counterparts. Maternal sensitivity is thought to support infants' stress response, but its role in moderating the effects of altered SLC6A4 methylation is unknown...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/28954564/maternal-and-neonatal-outcomes-among-pregnant-women-with-fibromyalgia-a-population-based-study-of-12-million-births
#13
Glenda Gatan Magtanong, Andrea R Spence, Nicholas Czuzoj-Shulman, Haim Arie Abenhaim
PURPOSE: Fibromyalgia (FM) is a rheumatologic disorder marked by chronic, widespread pain and associated comorbid conditions. The purpose of our study was to evaluate the effect of FM on maternal and neonatal outcomes. METHODS: Using the Healthcare Cost and Utilization Project Nationwide Inpatient Sample from 1999 to 2013, we conducted a population-based retrospective cohort study consisting of women who delivered during that period. Logistic regression was used to compare maternal and neonatal outcomes among pregnancies in women with and without FM...
September 27, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28933266/intravenous-paracetamol-dosing-guidelines-for-pain-management-in-pre-term-neonates-using-the-paediatric-study-decision-tree
#14
P Mian, C A J Knibbe, E A M Calvier, D Tibboel, K Allegaert
BACKGROUND: Intravenous paracetamol (acetaminophen) has not been licensed for analgesia in preterm neonates or infants < 2 years, respectively, in Europe and the United States. A variety of dosing regimens is therefore used off-label. Because evidence supports the use of the same target mean steady state paracetamol concentration (Cssmean, 9-11 mg/L) for pain relief in neonates compared to older children and adults, dosing regimens based on this Cssmean were evaluated in a two-step approach...
September 21, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28920044/effect-of-multisensory-stimulation-on-pain-of-eye-examination-in-preterm-infants
#15
Hossein Zeraati, Javad Shahinfar, Hamidreza Behnam Vashani, Tayebeh Reyhani
BACKGROUND: Eye examination as one of the painful procedures for retinopathy of prematurity screening can cause some pain-related physiological and behavioral changes in preterm infants. Multisensory stimulation is an analgesic non-pharmacological method that has analgesic effects on infants during painful procedures. OBJECTIVES: This study aimed to determine the effect of multisensory stimulation on induced pain during eye examination for retinopathy of prematurity screening in preterm infants...
February 2017: Anesthesiology and Pain Medicine
https://www.readbyqxmd.com/read/28918395/non-invasive-high-frequency-oscillatory-ventilation-in-preterm-infants-a-randomised-controlled-cross-over-trial
#16
Daniel Klotz, Hendryk Schneider, Stefan Schumann, Benjamin Mayer, Hans Fuchs
OBJECTIVE: Non-invasive high-frequency oscillatory ventilation (nHFOV) has recently been described as a novel mode of respiratory support for premature infants. This study was designed to determine whether nHFOV decreases CO2 partial pressure (pCO2) in premature infants more effectively than non-invasive continuous positive airway pressure (nCPAP). DESIGN: Non-blinded prospective randomised controlled cross-over study. SETTING: University Medical Center tertiary neonatal intensive care unit...
September 16, 2017: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/28914355/nasal-injury-and-comfort-with-jet-versus-bubble-continuous-positive-airway-pressure-delivery-systems-in-preterm-infants-with-respiratory-distress
#17
Jafar Khan, Venkataseshan Sundaram, Srinivas Murki, Anuj Bhatti, Shiv Sajan Saini, Praveen Kumar
Nasal injuries with use of nasal continuous positive airway pressure (CPAP) range from blanching of nasal tip to septal necrosis and septal drop. This analysis was done in preterm neonates of < 34-week gestation, who received nasal CPAP as primary support as part of a randomized trial comparing Jet device with Bubble device for delivery of CPAP, both through nasal prongs of different structure, make and fixation methods. Nasal injury was assessed using a validated nasal injury score. Out of 170 neonates enrolled, 103 (61%) had nasal injuries; moderate and severe injuries were observed in 18 (11%) and 8 (5%) infants, respectively...
December 2017: European Journal of Pediatrics
https://www.readbyqxmd.com/read/28867654/preterm-behavioral-epigenetics-a-systematic-review
#18
REVIEW
Livio Provenzi, Elena Guida, Rosario Montirosso
Behavioral epigenetics is revealing new pathways that lead individuals from early adversity exposures to later-in-life detrimental outcomes. Preterm birth constitutes one of the major adverse events in human development. Preterm infants are hospitalized in the Neonatal Intensive Care Unit (NICU) where they are exposed to life-saving yet pain-inducing procedures and to protective care. The application of behavioral epigenetics to the field of preterm studies (i.e., Preterm Behavioral Epigenetics, PBE) is rapidly growing and holds promises to provide valid insights for research and clinical activity...
September 1, 2017: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/28827932/comparison-of-neonatal-pain-agitation-and-sedation-scale-with-premature-infant-pain-profile-for-the-assessment-of-acute-prolonged-pain-in-neonates-on-assisted-ventilation-a-prospective-observational-study
#19
Saumil Ashvin Desai, Ruchi Nimish Nanavati, Bonny Bipin Jasani, Nandkishor Kabra
AIM: This study aimed to compare Neonatal Pain, Agitation, and Sedation Scale (N-PASS) with Premature Infant Pain Profile (PIPP) for the assessment of acute prolonged pain in ventilated neonates. METHODS: This study was conducted in two phases. In phase 1 of the study, we assessed whether neonates on assisted ventilation experienced acute prolonged pain. In phase 2, the aim was to compare N-PASS with PIPP for the assessment of acute prolonged pain in neonates on assisted ventilation...
July 2017: Indian Journal of Palliative Care
https://www.readbyqxmd.com/read/28822735/-the-care-of-skin-lesions-caused-by-extravasation-of-intravenous-fluids-in-peripheral-venous-perfusion
#20
C Ly
INTRODUCTION: Infiltration and extravasation account for 23-78 % of the complications stemming from peripheral venous perfusions in neonatal intensive care units. Their consequences, sometimes dramatic, can be pain, infections, or even loss of skin, which can lead to nerve and/or muscle damage, particularly severe for preterm neonates. Today there are no recommendations on the care of these lesions, which can lead to an erroneous choice or to a delay in the possible treatments. OBJECTIVE: This review of the literature aims to explore and propose elements of therapeutic care collected in the scientific literature...
September 2017: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
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