Matteo Micucci, Roberta Budriesi, Rita Aldini, Romana Fato, Christian Bergamini, Fabio Vivarelli, Donatella Canistro, Cristiano Bolchi, Alberto Chiarini, Nicola Rizzardi, Marco Pallavicini, Maria Frosini, Andrea Angeletti
Ellagitannins may have a beneficial impact in cardiovascular diseases. The aim of the study was to evaluate the effect of high-fat diet (HFD) and the efficacy of Castanea sativa Mill. bark extract (ENC) on cardiac and vascular parameters. Rats were fed with regular diet, (RD, n = 15), HFD (n = 15), RD + ENC (20 mg/kg/day by gavage, n = 15), and HFD + ENC (same dose, n = 15) and the effects on body weight, biochemical serum parameters, and inflammatory cytokines determined. Cardiac functional parameters and aorta contractility were also assessed on isolated atria and aorta...
April 2021: Phytotherapy Research: PTR