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left atria obesity

Jon V Norvik, Henrik Schirmer, Kirsti Ytrehus, Trond G Jenssen, Svetlana N Zykova, Anne E Eggen, Bjørn O Eriksen, Marit D Solbu
BACKGROUND: Heart failure with preserved ejection fraction is closely associated with diastolic dysfunction and related to obesity and female sex. We investigated whether adiponectin, an adipocyte-secreted protein hormone with cardioprotective effects, was associated with indices of diastolic dysfunction, and whether the association was sex dependent. METHODS: We conducted a cross-sectional study on 1165 women and 896 men without diabetes. We stratified the multivariable adjusted logistic regression analyses and the fractional polynomial regression analyses according to sex, with echocardiographic markers of diastolic dysfunction as dependent variables, and adiponectin as the independent variable of interest...
March 14, 2017: BMC Cardiovascular Disorders
Fatma Hizal Erdem, Serkan Ozturk, Davut Baltaci, Ibraham Donmez, Aytekin Alçelik, Selim Ayhan, Mehmet Yaz
INTRODUCTION: Obesity is associated with atrial fibrillation and is known as an independent risk factor. The aim of our study was to investigate if there was any association between the body mass index and atrial electromechanical intervals in obese and non-obese patients. METHODS: Seventy patients were enrolled in the study. Body mass index (BMI), functional capacity, and fasting blood sugar were evaluated; then, these patients were divided into two groups, patients who had a BMI ≥ 30 were known as obese (35 patients) and those who had a BMI < 30 were known as non-obese patients...
December 2015: Acta Cardiologica
Yasuo Okumura, Ichiro Watanabe, Koichi Nagashima, Kazumasa Sonoda, Naoko Sasaki, Rikitake Kogawa, Keiko Takahashi, Kazuki Iso, Kimie Ohkubo, Toshiko Nakai, Rie Takahashi, Yoshiki Taniguchi, Masako Mitsumata, Mizuki Nikaido, Atsushi Hirayama
BACKGROUND: Because obesity is an important risk factor for atrial fibrillation (AF), we conducted an animal study to examine the effect of a high-fat diet (HFD) on atrial properties and AF inducibility. METHODS: Ten 8-week-old pigs (weight, 18-23 kg) were divided into two groups. For 18 weeks, five pigs were fed a HFD (HFD group) and five were fed a normal diet (control group). Maps of atrial activation and voltages during sinus rhythm were created for all pigs using the EnSite NavX system...
December 2015: Journal of Arrhythmia
Filippo Perbellini, Renata S M Gomes, Silvia Vieira, Dougal Buchanan, Sophia Malandraki-Miller, Arne A N Bruyneel, Maria da Luz Sousa Fialho, Vicky Ball, Kieran Clarke, Giuseppe Faggian, Carolyn A Carr
UNLABELLED: Mesenchymal stem cells offer a promising approach to the treatment of myocardial infarction and prevention of heart failure. However, in the clinic, cells will be isolated from patients who may be suffering from comorbidities such as obesity and diabetes, which are known to adversely affect progenitor cells. Here we determined the effect of a high-fat diet (HFD) on mesenchymal stem cells from cardiac and adipose tissues. Mice were fed a HFD for 4 months, after which cardiosphere-derived cells (CDCs) were cultured from atrial tissue and adipose-derived mesenchymal cells (ADMSCs) were isolated from epididymal fat depots...
December 2015: Stem Cells Translational Medicine
Florent Le Ven, Karine Bibeau, Élianne De Larochellière, Helena Tizón-Marcos, Stéphanie Deneault-Bissonnette, Philippe Pibarot, Christian F Deschepper, Éric Larose
AIMS: Assessment of cardiac anatomy and function by cardiovascular magnetic resonance (CMR) is accurate and reproducible and is commonly performed to clarify borderline results obtained by other techniques. Normal reference values are lacking in a large sample of young healthy adults. As CMR is increasingly solicited to discriminate normality from equivocal disease in this population, we sought to determine reliable reference values. METHODS AND RESULTS: A sample of 434 Caucasian adults aged 26 ± 4 years (45% male) without cardiovascular disease or risk factors (including obesity and smoking) underwent CMR...
September 2016: European Heart Journal Cardiovascular Imaging
Ryan P O'Connell, Hassan Musa, Mario San Martin Gomez, Uma Mahesh Avula, Todd J Herron, Jerome Kalifa, Justus M B Anumonwo
BACKGROUND: Epicardial adiposity and plasma levels of free fatty acids (FFAs) are elevated in atrial fibrillation, heart failure and obesity, with potentially detrimental effects on myocardial function. As major components of epicardial fat, FFAs may be abnormally regulated, with a potential to detrimentally modulate electro-mechanical function. The cellular mechanisms underlying such effects of FFAs are unknown. OBJECTIVE: To determine the mechanisms underlying electrophysiological effects of palmitic (PA), stearic (SA) and oleic (OA) FFAs on sheep atrial myocytes...
2015: PloS One
Hoda Ahmed, Wael Abuzeid
No abstract text is available yet for this article.
August 2015: Canadian Journal of Cardiology
R K Chilukoti, A Giese, W Malenke, G Homuth, A Bukowska, A Goette, S B Felix, J Kanaan, H-G Wollert, K Evert, S Verheule, P Jais, S N Hatem, U Lendeckel, C Wolke
PURPOSE: Atrial fibrillation (AF) has been associated with increased volumes of epicardial fat and atrial adipocyte accumulation. Underlying mechanisms are not well understood. This study aims to identify rapid atrial pacing (RAP)/AF-dependent changes in atrial adipocyte/adipositas-related gene expression (AARE). METHODS: Right atrial (RA) and adjacent epicardial adipose tissue (EAT) samples were obtained from 26 patients; 13 with AF, 13 in sinus rhythm (SR). Left atrial (LA) samples were obtained from 9 pigs (5 RAP, 4 sham-operated controls)...
2015: International Journal of Cardiology
Stavroula N Psychari, Nectaria Rekleiti, Nikolaos Papaioannou, Evangelia Varhalama, Christos Drakoulis, Thomas S Apostolou, Efstathios K Iliodromitis
Nonalcoholic fatty liver disease (NAFLD) is closely related to insulin resistance and the metabolic syndrome and might be an important cardiovascular (CV) risk factor. Epicardial adipose tissue (EAT) has been implicated in the pathogenesis of obesity-related CV disease. In an NAFLD population, we investigated EAT thickness and its possible relations to NAFLD and cardiac structure and function. This was an observational study of 57 patients with NAFLD and 48 age-matched controls. Patients with NAFLD had significantly higher body mass index (P < ...
January 2016: Angiology
Marijana Tadic, Cesare Cuspidi
Epidemic of obesity, especially morbid obesity, among children and adolescents, is a key factor associated with the dramatic increase in prevalence of type 2 diabetes mellitus, arterial hypertension, and metabolic syndrome in this population. Furthermore, childhood obesity represents a very important predictor of obesity in adulthood that is related to cardiovascular and cerebrovascular diseases. Overweight and obesity in children and adolescents are associated with impairment of cardiac structure and function...
August 2015: Journal of Cardiovascular Medicine
Massimiliano Fedecostante, Francesco Spannella, Federico Giulietti, Emma Espinosa, Paolo Dessì-Fulgheri, Riccardo Sarzani
Ambulatory blood pressure monitoring (ABPM) is central in the management of hypertension. Factors related to BP, such as body mass index (BMI), may differently affect particular aspects of 24-hour ABPM profiles. However, the relevance of BMI, the most used index of adiposity, has been underappreciated in the determination of specific aspects of 24-hour ABPM profiles in hypertension. The authors evaluated the association between BMI and aspects of ABPM together with their associations with cardiac remodeling in 1841 patients...
February 2015: Journal of Clinical Hypertension
Manish Bansal, Ravi R Kasliwal
A 58-year-old obese woman with rheumatic heart disease who had undergone balloon mitral valvuloplasty 13 years earlier presented with progressively increasing dyspnea on exertion for the previous month. She had no history of systemic embolization and was not receiving anticoagulation. The physical..
January 1, 2015: New England Journal of Medicine
Kevin P Cohoon, Matylda Mazur, Robert D McBane, Siva Ketha, Naser Ammash, Waldemar E Wysokinski
BACKGROUND: Obesity is a risk factor for non-valvular atrial fibrillation (NVAF), diabetes mellitus, and hypertension. Adiponectin, a unique biomarker of adipose tissue, has antiinflammatory, insulin-sensitizing, and antiatherogenic properties and is known to be higher in women. The relationship between adiponectin, gender, and thromboembolic risk in atrial fibrillation however is unknown. METHODS: The relationship between gender, adiponectin levels, and echocardiographic measures of blood stagnation and left atrial appendage thrombus (LAAT) was assessed in 209 patients with NVAF (55 women and 154 men; mean age 63 ± 14 years) compared to 70 normal sinus rhythm controls (29 women and 41 men; mean age 64 ± 14 years)...
February 15, 2015: International Journal of Cardiology
Hikmet Yorgun, Uğur Canpolat, Kudret Aytemir, Tuncay Hazırolan, Levent Şahiner, Ergün Barış Kaya, Giray Kabakci, Lale Tokgözoğlu, Necla Özer, Ali Oto
Epicardial adipose tissue (EAT), as an endocrine organ, may serve as a source of pro-inflammatory cytokines. Also, given the strong relationship between atrial fibrillation (AF), obesity and inflammation, the purpose of this study was to investigate the association of non-valvular AF with epicardial and periatrial fat. A total of 618 (192 in sinus rhythm, 169 with paroxysmal AF, 133 with persistent AF and 124 with permanent AF) patients who underwent CT angiography for the evaluation of CAD or pulmonary vein anatomy before catheter ablation were enrolled in this study...
March 2015: International Journal of Cardiovascular Imaging
Ragab A Mahfouz, Abdelaziz Gomma, Mohamed Goda, Mohamed Safwat
BACKGROUND: The main objective of the study was to assess the strain measures (peak systolic longitudinal strain [LAS] and stiffness index [LASt]) and their relation to insulin resistance in obese children. METHODS AND RESULTS: Eighty obese children (body mass index was 28.2 ± 3.1) and 60 age-matched healthy nonobese children were recruited. Conventional, tissue Doppler imaging LAS and LASt were measured for all children using 2D speckle tracking imaging (2DSI)...
July 2015: Echocardiography
Pu Zong, Lili Zhang, Nada M Shaban, Jessica Peña, Leng Jiang, Cynthia C Taub
BACKGROUND: Accurate normalization of cardiac chamber size in the obese population is a challenge. The aim of this study was to develop and assess the performance of allometric models for scaling left heart chamber sizes, including left atrial anteroposterior dimension (LADAP), left atrial volume (LAV), left ventricular end-diastolic volume (LVEDV), and left ventricular end-diastolic dimension (LVEDD), in an obese population. METHODS: To normalize left heart chamber measurements (Y: LADAP, LAV, LVEDV, and LVEDD) to body size variables (X: height, weight, body mass index, and body surface area), both isometric models (Y = aX) and optimal allometric models (Y = aX(b)) were tested...
December 2014: Journal of the American Society of Echocardiography
Lorraine Levitt Katz, Samuel S Gidding, Fida Bacha, Kathryn Hirst, Siripoom McKay, Laura Pyle, Joao A C Lima
Data on cardiovascular disease (CVD) risk in adolescents with type 2 diabetes (T2D) are limited. Echocardiography was performed in the last year of the Treatment Options for type 2 Diabetes in Adolescents and Youth (TODAY) clinical trial (median 4½ yr from diagnosis of T2D, average age 18 yr), including MMode and 2D measurements of left ventricular (LV) and left atrial (LA) dimensions, LV tissue Doppler imaging (TDI), and tricuspid annular plane systolic excursion (TAPSE). Relationships between cardiac structure and function with demographic characteristics and baseline and change-from-baseline in CVD risk factors were examined in 455 participants...
February 2015: Pediatric Diabetes
Yau-Huei Lai, Chuan-Chuan Liu, Jen-Yuan Kuo, Ta-Chuan Hung, Yih-Jer Wu, Hung-I Yeh, Bernard E Bulwer, Chung-Lieh Hung
BACKGROUND: The effect of body fat distribution on left ventricular (LV) mass and geometry has been recently recognized. However, data regarding circulating inflammatory markers in relation to regional visceral fat deposits, which are metabolically active tissues that can impact cardiac structural remodeling, remain sparse. HYPOTHESIS: We hypothesized that obesity has adverse effects on cardiac function and structure. METHODS: We consecutively studied 1071 asymptomatic subjects (age 49...
March 2014: Clinical Cardiology
Yung-Kuo Lin, Yao-Chang Chen, Jen-Hung Huang, Yenn-Jiang Lin, Shiang-Suo Huang, Shih-Ann Chen, Yi-Jen Chen
BACKGROUND: Obesity is an important risk factor for atrial fibrillation (AF). Leptin is an important adipokine. However, it is not clear whether leptin directly modulates the electrophysiological characteristics of atrial myocytes. RESULTS: Whole cell patch clamp and indo-1 fluorescence were used to record the action potentials (APs) and ionic currents in isolated rabbit left atrial (LA) myocytes incubated with and without (control) leptin (100 nM) for 1 h to investigate the role of leptin on atrial electrophysiology...
2013: Journal of Biomedical Science
Cesare Cuspidi, Marta Rescaldani, Marijana Tadic, Carla Sala, Guido Grassi
BACKGROUND: Morbid obesity, a condition increasingly treated with bariatric procedures, is strongly associated with left ventricular (LV) hypertrophy and impaired LV function. We analyzed the literature to provide comprehensive information on cardiac structural and functional changes, as assessed by imaging techniques, after bariatric surgery. METHODS: The studies were identified by the following search terms: "bariatric surgery," "obesity," "left ventricle," "left ventricular hypertrophy," "cardiac hypertrophy," "ventricular dysfunction," "left ventricular hypertrophy regression," "echocardiography," "magnetic resonance imaging," and "cardiac imaging techniques...
February 2014: American Journal of Hypertension
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