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https://www.readbyqxmd.com/read/29044793/clustering-of-prevention-behaviours-in-patients-with-high-risk-primary-melanoma
#1
Adèle C Green, Maria Celia B Hughes, Lena A von Schuckmann, Kiarash Khosrotehrani, B Mark Smithers
OBJECTIVE: Because melanoma patients are at high risk of further disease, we aimed to study their melanoma prevention behaviours. METHODS: In a large cohort of patients newly diagnosed with high-risk melanoma in Queensland, Australia, we assessed clustering of preventive behaviours using latent class analysis. We assessed associated factors with prevalence proportion ratios (PPRs) and 95% confidence intervals (CIs) estimated by Poisson regression, and also if preventive behaviour was associated with better tumour prognosis at diagnosis...
October 16, 2017: Psycho-oncology
https://www.readbyqxmd.com/read/29038754/histamine-2-receptor-antagonist-famotidine-modulates-cardiac-stem-cell-characteristics-in-hypertensive-heart-disease
#2
Sherin Saheera, Ajay G Potnuri, Renuka Nair
BACKGROUND: Cardiac stem cells (CSCs) play a vital role in cardiac homeostasis. A decrease in the efficiency of cardiac stem cells is speculated in various cardiac abnormalities. The maintenance of a healthy stem cell population is essential for the prevention of adverse cardiac remodeling leading to cardiac failure. Famotidine, a histamine-2 receptor antagonist, is currently used to treat ulcers of the stomach and intestines. In repurposing the use of the drug, reduction of cardiac hypertrophy and improvement in cardiac function of spontaneously hypertensive rats (SHR) was reported by our group...
2017: PeerJ
https://www.readbyqxmd.com/read/29036406/effects-of-computerized-decision-support-system-implementations-on-patient-outcomes-in-inpatient-care-a-systematic-review
#3
Julian Varghese, Maren Kleine, Sophia Isabella Gessner, Sarah Sandmann, Martin Dugas
Objectives: To systematically classify the clinical impact of computerized clinical decision support systems (CDSSs) in inpatient care. Materials and Methods: Medline, Cochrane Trials, and Cochrane Reviews were searched for CDSS studies that assessed patient outcomes in inpatient settings. For each study, 2 physicians independently mapped patient outcome effects to a predefined medical effect score to assess the clinical impact of reported outcome effects. Disagreements were measured by using weighted kappa and solved by consensus...
September 23, 2017: Journal of the American Medical Informatics Association: JAMIA
https://www.readbyqxmd.com/read/29032067/a-rare-case-of-gestational-choriocarcinoma-presenting-as-cornual-ectopic-pregnancy
#4
Vanessa Han, Stephen Kaye
BACKGROUND: Choriocarcinoma associated with cornual pregnancy is extremely rare. To our knowledge, only three other cases have been reported in the literature. CASE: A 38-year-old woman was found to have a left cornual ectopic pregnancy on ultrasound after presenting with abdominal pain, irregular vaginal bleeding, and a positive pregnancy test. Laparoscopy confirmed the diagnosis and she underwent total abdominal hysterectomy. Three weeks later, she presented with vaginal bleeding...
October 11, 2017: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
https://www.readbyqxmd.com/read/29030607/ccdc88b-is-required-for-pathogenesis-of-inflammatory-bowel-disease
#5
Nassima Fodil, Neda Moradin, Vicki Leung, Jean-Frederic Olivier, Irena Radovanovic, Thiviya Jeyakumar, Manuel Flores Molina, Ashley McFarquhar, Romain Cayrol, Dominique Bozec, Naglaa H Shoukry, Michiaki Kubo, Julia Dimitrieva, Edouard Louis, Emilie Theatre, Stephanie Dahan, Yukihide Momozawa, Michel Georges, Garabet Yeretssian, Philippe Gros
Inflammatory bowel disease (IBD) involves interaction between host genetic factors and environmental triggers. CCDC88B maps within one IBD risk locus on human chromosome 11q13. Here we show that CCDC88B protein increases in the colon during intestinal injury, concomitant with an influx of CCDC88B(+)lymphoid and myeloid cells. Loss of Ccdc88b protects against DSS-induced colitis, with fewer pathological lesions and reduced intestinal inflammation in Ccdc88b-deficient mice. In a T cell transfer model of colitis, Ccdc88b mutant CD4(+) T cells do not induce colitis in immunocompromised hosts...
October 13, 2017: Nature Communications
https://www.readbyqxmd.com/read/29027576/neonatal-ulcerative-colitis-associated-with-familial-mediterranean-fever-a-case-report
#6
Elif Sag, Ferhat Demir, Mustafa Emre Ercin, Mukaddes Kalyoncu, Murat Cakir
Neonatal inflammatory bowel disease (IBD) is a subclass of very early onset IBD that includes children younger than 1 month. It is characterized by more colonic involvement and monogenetic etiology, resistance to classical anti-inflammatory/immunomodulatory treatments and associated with colitis in first-degree family members. Herein we report a 3 month-old girl who was admitted with bloody diarrhea since 10 days of age. Her symptoms persist despite diet elimination. She was diagnosed with neonatal ulcerative colitis (UC) based on clinical, laboratory and histopathological examination...
October 13, 2017: Rheumatology International
https://www.readbyqxmd.com/read/29026366/trigeminal-trophic-syndrome-associated-with-the-use-of-synthetic-marijuana
#7
Fawad A Khan, Rinu Manacheril, Robin Ulep, Julie E Martin, Anil Chimakurthy
BACKGROUND: Trigeminal trophic syndrome (TTS) is an uncommon disorder of the trigeminal nerve tract and trigeminal brainstem nucleus. The syndrome is characterized by a triad of unilateral crescentic ulcers with anesthesia and paresthesias of the involved trigeminal dermatomes. CASE REPORT: A 24-year-old right-handed black female presented to our emergency department with a 4-week history of rapidly progressive painless desquamation/denudation of skin over her right face and scalp...
2017: Ochsner Journal
https://www.readbyqxmd.com/read/29018816/comparative-evaluation-between-sulfasalazine-alone-and-in-combination-with-herbal-medicine-on-dss-induced-ulcerative-colitis-mice
#8
Mi-Rae Shin, Kyeong Jo Kim, Soo Hyun Kim, Su Ji Kim, Bu-Il Seo, Hyo-Jin An, Seong-Soo Roh
The present study aimed to investigate the comparative evaluation of pharmacological efficacy between sulfasalazine alone and sulfasalazine in combination with herbal medicine on dextran sodium sulfate- (DSS-) induced UC in mice. Balb/c mice received 5% DSS in drinking water for 7 days to induce colitis. Animals were divided into five groups (n = 9): Group I (normal group), Group II (DSS control group), Group III (DSS + sulfasalazine (30 mg/kg)), Group IV (DSS + sulfasalazine (60 mg/kg)), and Group V (DSS + sulfasalazine (30 mg/kg) + Cinnamomi Cortex and Bupleuri Radix mixture (30 mg/kg) (SCB))...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28992171/points-to-consider-for-skin-ulcers-in-systemic-sclerosis
#9
REVIEW
Felice Galluccio, Yannick Allanore, Lázló Czirjak, Daniel E Furst, Dinesh Khanna, Marco Matucci-Cerinic
This article discusses points to consider when undertaking a clinical trial to test therapy for skin ulcers in SSc. A validated definition of skin ulcers should be used if available. Defining a uniform SSc patient population, including consideration of disease duration, history of digital ulcers and capillaroscopic patterns, is important. Excluding confounding factors such as infection, calcinosis and trauma should be strongly considered, or at least accounted for, in defining patients. Outcome measures such as time to healing, prevention of new ulcers, function, pain and objective measures such as US, laser Doppler and thermography can be considered as outcome measures, although their validation has not yet been achieved and efforts may be needed to validate them before use...
September 1, 2017: Rheumatology
https://www.readbyqxmd.com/read/28991993/use-of-the-spectrophotometric-color-method-for-the-determination-of-the-age-of-skin-lesions-on-the-pig-carcass-and-its-relationship-with-gene-expression-and-histological-and-histochemical-parameters
#10
M Vitali, S Conte, M Lessard, K Deschêne, M O Benoit-Biancamano, C Celeste, G Martelli, L Sardi, F Guay, L Faucitano
The presence of lesions on the pig carcass is an indicator of poor animal welfare and has economic impact as it downgrades the carcass value. The assessment of the age of lesions on the carcass may help identify risk factors and ultimately prevent their occurrence. The aim of this study was to assess the age of lesions on pig carcasses through spectrophotometric color evaluation and to relate the results with gene expression and histological and histochemical parameters. A total of 96 barrows were mixed 4 times over 3 d before slaughter and 80 lesions were selected after skin lesion observations to define 4 age categories: < 7 h (T1), 7-25 h (T2), 25-30 h (T3), and 49-54 h (T4)...
September 2017: Journal of Animal Science
https://www.readbyqxmd.com/read/28991483/vasoactive-intestinal-peptide-nanomedicine-for-the-management-of-inflammatory-bowel-disease
#11
Dulari Jayawardena, Arivarasu N Anbazhagan, Grace Guzman, Pradeep K Dudeja, Hayat Onyuksel
Inflammatory bowel disease (IBD) is a chronic relapsing disorder of the intestine, with increasing incidence worldwide. At present, the management of IBD is an unmet medical need due to the ineffectiveness of currently available drugs in treating all patients, and there is strong demand for novel therapeutics. In this regard, vasoactive intestinal peptide, a potent anti-inflammatory endogenous hormone, has shown promise in managing multiple immune disorders in animal models. However, when administered in the free form, VIP undergoes rapid degradation in vivo, and with continuous infusion, it causes severe dose limiting side effects...
October 9, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28991157/geranylgeranylacetone-ameliorates-intestinal-radiation-toxicity-by-preventing-endothelial-cell-dysfunction
#12
Na-Kyung Han, Ye Ji Jeong, Bo-Jeong Pyun, Yoon-Jin Lee, Sung-Ho Kim, Hae-June Lee
Radiation-induced intestinal toxicity is common among cancer patients after radiotherapy. Endothelial cell dysfunction is believed to be a critical contributor to radiation tissue injury in the intestine. Geranylgeranylacetone (GGA) has been used to treat peptic ulcers and gastritis. However, the protective capacity of GGA against radiation-induced intestinal injury has not been addressed. Therefore, we investigated whether GGA affects intestinal damage in mice and vascular endothelial cell damage in vitro...
October 7, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28990362/an-explorative-study-on-the-validity-of-various-definitions-of-a-2%C3%A2-2%C3%A2-c-temperature-threshold-as-warning-signal-for-impending-diabetic-foot-ulceration
#13
Anke M Wijlens, Samantha Holloway, Sicco A Bus, Jaap J van Netten
Home monitoring of skin temperature is effective to prevent diabetic foot ulceration. We explored the validity of various definitions for the >2·2°C left-to-right threshold used as a warning signal for impending ulceration. Twenty patients with diabetes and peripheral neuropathy monitored their skin temperature with an infrared thermometer at the plantar hallux, metatarsal heads, midfoot and heel four times a day for 6 consecutive days. Environmental temperature and walking activity were monitored and associated with foot temperature...
October 9, 2017: International Wound Journal
https://www.readbyqxmd.com/read/28988757/pressure-ulcers-in-critically-ill-patients-preventable-by-non-sedation-a-substudy-of-the-nonseda-trial
#14
Helene K Nedergaard, Trine Haberlandt, Palle Toft, Hanne Irene Jensen
OBJECTIVE: Pressure ulcers still pose a significant clinical challenge to critically ill patients. This study is a substudy of the multicenter NONSEDA-trial, where critically ill patients were randomised to sedation or non-sedation during mechanical ventilation. The objective of this substudy was to assess if non-sedation affected the occurrence of pressure ulcers. DESIGN: Retrospective assessment of data from a single NONSEDA-trial site. SETTING: Mixed intensive care unit...
October 5, 2017: Intensive & Critical Care Nursing: the Official Journal of the British Association of Critical Care Nurses
https://www.readbyqxmd.com/read/28988197/vonoprazan-prevents-ulcer-recurrence-during-long-term-nsaid-therapy-randomised-lansoprazole-controlled-non-inferiority-and-single-blind-extension-study
#15
Yuji Mizokami, Kazunori Oda, Nobuo Funao, Akira Nishimura, Satoshi Soen, Takashi Kawai, Kiyoshi Ashida, Kentaro Sugano
OBJECTIVE: To assess the non-inferiority of vonoprazan to lansoprazole for secondary prevention of non-steroidal anti-inflammatory drug (NSAID)-induced peptic ulcer (PU) and the safety of vonoprazan during extended use. DESIGN: A phase 3, 24-week, multicenter, randomised, double-blind (DB), active-controlled study, followed by a phase 3, ≥28 week, multicenter, single-blind, parallel-group extension study (EXT) in outpatients (n=642) receiving long-term NSAID therapy who are at risk of PU recurrence...
October 7, 2017: Gut
https://www.readbyqxmd.com/read/28985988/a-novel-screwing-method-to-prevent-decubitus-and-skin-ulcer-in-severe-kyphoscoliosis-after-spinal-cord-injury-a-case-report
#16
Shoji Seki, Yoshiharu Kawaguchi, Hayato Mine, Tomoatsu Kimura
No abstract text is available yet for this article.
October 3, 2017: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
https://www.readbyqxmd.com/read/28983285/microbiota-of-chronic-diabetic-wounds-ecology-impact-and-potential-for-innovative-treatment-strategies
#17
REVIEW
Sónia G Pereira, João Moura, Eugénia Carvalho, Nuno Empadinhas
World Health Organization considered diabetes as one of the 20th century epidemics, estimating that over 10% of the world population is diabetic or at high risk. Self-assessment studies indicate that diabetic patients consider chronic wounds to affect their quality of life more dramatically than vision loss or renal failure. In addition to being the main reason for diabetic patients' hospitalization, the economic burden of diabetic chronic wounds is close to 1% of United Kingdom and United States health systems budgets, which exceeds the funds allocated to the treatment of some types of cancer in both countries...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28981652/prevalence-of-malnutrition-and-nutritional-characteristics-of-patients-with-inflammatory-bowel-disease
#18
María José Casanova, Maria Chaparro, Begoña Molina, Olga Merino, Ricardo Batanero, Carmen Dueñas-Sadornil, Pilar Robledo, Ana María Garcia-Albert, Maria Bienvenida Gómez-Sánchez, Xavier Calvet, Maria Del Roser Trallero, Miguel Montoro, Iria Vázquez, Mara Charro, Amaya Barragán, Francisco Martínez-Cerezo, Isabel Megias-Rangil, José María Huguet, Ezequiel Marti-Bonmati, Marta Calvo, Mariana Campderá, Margarita Muñoz-Vicente, Angel Merchante, Ansel David Ávila, Pilar Serrano-Aguayo, Ruth De Francisco, Daniel Hervías, Luis Bujanda, Gloria Esther Rodriguez, Luisa Castro-Laria, Manuel Barreiro-de Acosta, Manuel Van Domselaar, Patricia Ramirez de la Piscina, Javier Santos-Fernández, Alicia Algaba, Sandra Torra, Liliana Pozzati, Pilar López-Serrano, Maria Del Rosario Arribas, Maria Luisa Rincón, Andrés Camilo Peláez, Elena Castro, Antonio García-Herola, Cecilio Santander, Moisés Hernández-Alonso, Elisa Martín-Noguerol, María Gómez-Lozano, Tamara Monedero, Albert Villoria, Ariadna Figuerola, Andrés Castaño-García, Jesús M Banales, Laura Díaz-Hernández, Federico Argüelles-Arias, Javier López-Díaz, Isabel Pérez-Martínez, Noelia García-Talavera, Olivia Karina Nuevo-Siguairo, Sabino Riestra, Javier P Gisbert
Aims: This study sought to determine the prevalence of malnutrition in patients with inflammatory bowel disease, to analyse the dietary beliefs and behaviours of these patients, to study their body composition, to evaluate their muscular strength and to identify the factors associated with malnutrition in these patients. Methods: This was a prospective, multicentre study. Crohn's disease and ulcerative colitis patients from 30 Spanish centres, from the outpatient clinics, were included...
July 24, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28980911/acute-oral-tetrahydrobiopterin-administration-ameliorates-endothelial-dysfunction-in-systemic-sclerosis
#19
Daniel R Machin, Heather L Clifton, Russell S Richardson, D Walter Wray, Anthony J Donato, Tracy M Frech
OBJECTIVES: Systemic sclerosis (SSc) is a rare, autoimmune disease characterised by endothelial dysfunction, which is associated with peripheral vasculopathy, such as digital ulcers (DU). We sought to determine if acute oral administration of tetrahydrobiopterin (BH4), an essential cofactor for endothelial nitric oxide synthase, would augment endothelial function in patients with SSc. METHODS: Twelve SSc patients, of whom a majority had a history of DU, were studied 5 hours after oral BH4 administration (10 mg/kg body mass) or placebo on separate days using controlled, counterbalanced, double-blind, crossover experimental design...
September 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28980901/long-term-treatment-of-scleroderma-related-digital-ulcers-with-iloprost-a-cohort-study
#20
Michele Colaci, Federica Lumetti, Dilia Giuggioli, Serena Guiducci, Silvia Bellando-Randone, Ginevra Fiori, Marco Matucci-Cerinic, Clodoveo Ferri
OBJECTIVES: Raynaud's phenomenon and chronic/recurrent digital ulcers (DU) are main features of systemic sclerosis (SSc). Their treatment includes both systemic (i.e., iloprost) and local therapies. We report the therapeutic effects of iloprost in a cohort of SSc patients during a long-lasting follow-up period. METHODS: Fifty consecutive SSc patients (M/F 7/43, age at SSc diagnosis 43.5±12.7SD years) received iloprost infusions for 10±4.2SD years. Iloprost schedule consisted in monthly infusion at 0...
September 18, 2017: Clinical and Experimental Rheumatology
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