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https://www.readbyqxmd.com/read/28427745/how-to-approach-the-acute-respiratory-distress-syndrome-prevention-plan-and-prudence
#1
REVIEW
Younsuck Koh
The acute respiratory distress syndrome (ARDS) is typically manifested by refractory hypoxemia with high mortality. A correct diagnosis is the first step to achieve better outcomes. An early intervention to manage modifiable risk factors of ARDS development and the avoidance of aggravating factors that increase disease severity and progression should be carefully addressed. A management plan is necessary at an early stage of ARDS to determine the level of intensive care. It should be carefully decided which therapeutic measures should be performed depending on the patient׳s underlying clinical condition...
May 2017: Respiratory Investigation
https://www.readbyqxmd.com/read/28427109/traveler-s-diarrhea-vision-abnormalities-and-unsteady-gait-in-a-young-woman
#2
Tobias Mühling, Felix Gundling, Thomas Helmberger, Wolfgang Schepp
We report on the course of disease in a young woman, originally admitted with suspected refractory infectious tropical traveler's diarrhea. However, symptoms did not resolve upon either symptomatic or subsequent antibiotic therapy. When neurologic deterioration was observed, imaging studies revealed a dramatic series of thromboembolic events, including intracranial hemorrhage caused by extensive sinus vein thrombosis as well as thrombi of the right cardiac ventricle. Colonic mucosal biopsy samples finally led to the histologic diagnosis of ulcerative colitis...
April 2017: Zeitschrift Für Gastroenterologie
https://www.readbyqxmd.com/read/28426572/nonhealing-ulcers-in-patients-with-tophaceous-gout-a-systematic-review
#3
Gretl Lam, Frank L Ross, Ernest S Chiu
GENERAL PURPOSE: To provide information from a review of the literature about chronic ulcers associated with tophaceous gout. TARGET AUDIENCE: This continuing education activity is intended for physicians, physician assistants, nurse practitioners, and nurses with an interest in skin and wound care. LEARNING OBJECTIVES/OUTCOMES: After participating in this educational activity, the participant should be better able to:1. Identify the pathophysiology of tophaceous gout, its presentation, phases, and common comorbidities...
May 2017: Advances in Skin & Wound Care
https://www.readbyqxmd.com/read/28426473/modifiable-risk-factors-for-hospital-readmission-among-patients-with-inflammatory-bowel-disease-in-a-nationwide-database
#4
Edward L Barnes, Bharati Kochar, Millie D Long, Michael D Kappelman, Christopher F Martin, Joshua R Korzenik, Seth D Crockett
BACKGROUND: Previous studies suggest that disease activity alone does not reliably predict hospital readmission among patients with inflammatory bowel diseases (IBDs). Using a national database, we aimed to further describe the burden of readmissions for IBD and identify modifiable risk factors. METHODS: We performed a retrospective cohort study using 2013 data from the Nationwide Readmission Database (NRD). Using International Classification of Diseases, ninth Revision, Clinical Modification (ICD-9-CM) codes, we identified adult patients with discharge diagnoses of ulcerative colitis or Crohn's disease and ascertained diagnoses of anxiety, depression, chronic pain, tobacco use, and other comorbidities during index admission...
April 19, 2017: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/28424557/vedolizumab-toward-a-personalized-therapy-paradigm-for-people-with-ulcerative-colitis
#5
REVIEW
Robin J Dart, Mark A Samaan, Nick Powell, Peter M Irving
Ulcerative colitis (UC) is a chronic relapsing and remitting inflammatory bowel disease, with a characteristic leukocytic infiltration of the mucosa. Immunosuppression including anti-TNF-α therapy is a mainstay of treatment for many; however, systemic immunosuppression is not universally effective and is associated with potential side effects. The gut-tropic integrin α4β7, which is expressed on leukocytes, mediates migration from the circulation to the intestinal mucosa. Vedolizumab is a monoclonal antibody which blocks the egress of leukocytes via α4β7, preventing accumulation in the mucosa, and attenuating inflammation without systemic immunosuppression...
2017: Clinical and Experimental Gastroenterology
https://www.readbyqxmd.com/read/28421826/6-gingerol-improves-testicular-function-in-mice-model-of-chronic-ulcerative-colitis
#6
E O Farombi, I A Adedara, B O Ajayi, T E Idowu, O O Eriomala, F O Akinbote
The persistent inflammation and oxidative stress at the local site in ulcerative colitis reportedly extend to the testes via systemic circulation resulting in testicular dysfunction. The influence of 6-gingerol (6G), a phenolic compound isolated from Zingiber officinale, on colitis-mediated testicular dysfunction in mice was investigated in this study. Chronic ulcerative colitis was induced in mice using 2.5% dextran sulfate sodium (DSS) in drinking water for three cycles. Each cycle consisted of 7 consecutive days of exposure to DSS-treated water followed by 14 consecutive days of normal drinking water...
January 1, 2017: Human & Experimental Toxicology
https://www.readbyqxmd.com/read/28414254/lifestyle-intervention-for-adults-with-spinal-cord-injury-results-of-the-usc-rlanrc-pressure-ulcer-prevention-study
#7
Mike Carlson, Cheryl Lp Vigen, Salah Rubayi, Erna Imperatore Blanche, Jeanine Blanchard, Michal Atkins, Barbara Bates-Jensen, Susan L Garber, Elizabeth A Pyatak, Jesus Diaz, Lucia I Florindez, Joel W Hay, Trudy Mallinson, Jennifer B Unger, Stanley Paul Azen, Michael Scott, Alison Cogan, Florence Clark
CONTEXT/OBJECTIVE: Medically serious pressure injuries (MSPrIs), a common complication of spinal cord injury (SCI), have devastating consequences on health and well-being and are extremely expensive to treat. We aimed to test the efficacy of a lifestyle-based intervention designed to reduce incidence of MSPrIs in adults with SCI. DESIGN: A randomized controlled trial (RCT), and a separate study wing involving a nonrandomized standard care control group. SETTING: Rancho Los Amigos National Rehabilitation Center, a large facility serving ethnically diverse, low income residents of Los Angeles County...
April 17, 2017: Journal of Spinal Cord Medicine
https://www.readbyqxmd.com/read/28410791/gastrointestinal-safety-of-celecoxib-versus-naproxen-in-patients-with-cardiothrombotic-diseases-and-arthritis-after-upper-gastrointestinal-bleeding-concern-an-industry-independent-double-blind-double-dummy-randomised-trial
#8
Francis K L Chan, Jessica Y L Ching, Yee Kit Tse, Kelvin Lam, Grace L H Wong, Siew C Ng, Vivian Lee, Kim W L Au, Pui Kuan Cheong, Bing Y Suen, Heyson Chan, Ka Man Kee, Angeline Lo, Vincent W S Wong, Justin C Y Wu, Moe H Kyaw
BACKGROUND: Present guidelines are conflicting for patients at high risk of both cardiovascular and gastrointestinal events who continue to require non-steroidal anti-inflammatory drugs (NSAIDs). We hypothesised that a cyclooxygenase-2-selective NSAID plus proton-pump inhibitor is superior to a non-selective NSAID plus proton-pump inhibitor for prevention of recurrent ulcer bleeding in concomitant users of aspirin with previous ulcer bleeding. METHODS: For this industry-independent, double-blind, double-dummy, randomised trial done in one academic hospital in Hong Kong, we screened patients with arthritis and cardiothrombotic diseases who were presenting with upper gastrointestinal bleeding, were on NSAIDs, and require concomitant aspirin...
April 11, 2017: Lancet
https://www.readbyqxmd.com/read/28409210/how-common-are-foot-problems-among-individuals-with-diabetes-diabetic-foot-ulcers-in-the-dutch-population
#9
Robert M Stoekenbroek, Joost L C Lokin, Mark M Nielen, Erik S G Stroes, Mark J W Koelemay
AIMS/HYPOTHESIS: Contemporary data on diabetic foot ulcer prevalence are scarce. Most studies were conducted in the 1990s, reporting incidence rates of 1.9-2.6%. Since then the prevalence of diabetes has doubled and the organisation of diabetes care has undergone major changes. Up-to-date data that quantify the occurrence of diabetic foot ulcers are required and could serve as baseline measures for future studies. METHODS: Individuals with diabetes (n = 81,793) were identified from the NIVEL (Netherlands institute for health services research) Primary Care Database, which contains data for standardised routine care and is representative of the Dutch population...
April 13, 2017: Diabetologia
https://www.readbyqxmd.com/read/28408791/all-trans-retinoic-acid-modulates-tlr4-nf-%C3%AE%C2%BAb-signaling-pathway-targeting-tnf-%C3%AE-and-nitric-oxide-synthase-2-expression-in-colonic-mucosa-during-ulcerative-colitis-and-colitis-associated-cancer
#10
Hayet Rafa, Sarra Benkhelifa, Sonia AitYounes, Houria Saoula, Said Belhadef, Mourad Belkhelfa, Aziza Boukercha, Ryma Toumi, Imene Soufli, Olivier Moralès, Yvan de Launoit, Hassen Mahfouf, M'hamed Nakmouche, Nadira Delhem, Chafia Touil-Boukoffa
Colitis associated cancer (CAC) is the colorectal cancer (CRC) subtype that is associated with bowel disease such as ulcerative colitis (UC). The data on role of NF-κB signaling in development and progression of CAC were derived from preclinical studies, whereas data from human are rare. The aim of this work was to study the contribution of NF-κB pathway during UC and CAC, as well as the immunomodulatory effect of all-trans retinoic acid (AtRA). We analyzed the expression of NOS2, TNF-α, TLR4, and NF-κB, in colonic mucosa...
2017: Mediators of Inflammation
https://www.readbyqxmd.com/read/28407278/prevention-and-treatment-of-complications-of-selective-internal-radiation-therapy-expert-guidance-and-systematic-review
#11
REVIEW
Bruno Sangro, Diego Martínez-Urbistondo, Lourens Bester, Jose I Bilbao, Douglas M Coldwell, Patrick Flamen, Andrew Kennedy, Jens Ricke, Ricky A Sharma
Selective internal radiation therapy (SIRT or radioembolisation) by intraarterial injection of radioactive yttrium-90 ((90) Y)-loaded microspheres is increasingly used for the treatment of patients with liver metastases or primary liver cancer. The high-dose beta-radiation penetrates an average of only 2.5 mm from the source so that its effects are limited to the site of delivery. However the off-target diversion of (90) Y microspheres to tissues other than the tumor may lead to complications. The most prominent ones include: radiation gastritis and gastrointestinal (GI) ulcers, cholecystitis, radiation pneumonitis, and radioembolisation-induced liver disease (REILD)...
April 13, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/28406440/associations-between-folate-and-vitamin-b12-levels-and-inflammatory-bowel-disease-a-meta-analysis
#12
Yun Pan, Ya Liu, Haizhuo Guo, Majid Sakhi Jabir, Xuanchen Liu, Weiwei Cui, Dong Li
BACKGROUND: Inflammatory bowel disease (IBD) patients may be at risk of vitamin B12 and folate insufficiencies, as these micronutrients are absorbed in the small intestine, which is affected by IBD. However, a consensus has not been reached on the association between IBD and serum folate and vitamin B12 concentrations. METHODS: In this study, a comprehensive search of multiple databases was performed to identify studies focused on the association between IBD and serum folate and vitamin B12 concentrations...
April 13, 2017: Nutrients
https://www.readbyqxmd.com/read/28406423/epidemiological-aspects-of-genital-ulcers-at-the-sti-center-of-the-national-institute-of-public-hygiene-abidjan-c%C3%A3-te-d-ivoire-2008-to-2010
#13
D Z Gakoué, I Tiembré
Genital ulcers are among the seven syndromes of sexually transmitted infections (STIs) identified in Côte d'Ivoire. Ulcerative STIs present a public health problem because of their frequency and their role in the spread of HIV. Our objective was to investigate the epidemiological characteristics of genital ulcers observed in the STI center of the National Institute of Public Hygiene in Abidjan. This cross-sectional, descriptive and analytical study examined cases seen at the center in 2008 through 2010. We retrospectively reviewed all files of clients aged 10 and older who sought care for the first time at the STI center and received a clinical diagnosis, confirmed by the laboratory, of a STI...
February 1, 2017: Médecine et Santé Tropicales
https://www.readbyqxmd.com/read/28403297/knowledge-of-the-nursing-team-on-pressure-ulcer-prevention
#14
Nariani Souza Galvão, Maria Alice Barbosa Serique, Vera Lúcia Conceição de Gouveia Santos, Paula Cristina Nogueira
OBJECTIVE: describe and analyze the nursing team's knowledge about classification, evaluation and measures to prevent pressure ulcers (PU) in patients hospitalized in the ICU of a teaching hospital in the city of Manaus. METHOD: a descriptive and exploratory study was conducted after approval by a research ethics committee. Data were collected using a validated instrument. The study sample was made up of 40 nursing staff members, of whom 14 were nurses and 26 were nursing technicians/aides...
April 2017: Revista Brasileira de Enfermagem
https://www.readbyqxmd.com/read/28403284/unna-s-boot-experience-of-care-of-people-with-venous-ulcers
#15
Marcelo Henrique da Silva, Maria Cristina Pinto de Jesus, Deíse Moura de Oliveira, Miriam Aparecida Barbosa Merighi
OBJECTIVE: to understand the experience of care of people with venous ulcers using an Unna's boot. METHOD: a qualitative study, based on the social phenomenology by Alfred Schütz, was carried out with 12 adults interviewed in 2015. The statements were analyzed and organized in thematic categories. RESULTS: the following categories emerged: "Unna's boot annoyance versus wound improvement", "Difficulties for accessing care with the Unna's boot", "Care for healing and preventing recurrence", and "Receiving more attention from the healthcare professional"...
April 2017: Revista Brasileira de Enfermagem
https://www.readbyqxmd.com/read/28400897/postsurgical-pyoderma-gangrenosum-following-carpal-tunnel-release-a-rare-disease-following-a-common-surgery
#16
Michael R Ruebhausen, Shaun D Mendenhall, Michael W Neumeister, Nada N Berry
Objective: Postsurgical pyoderma gangrenosum is a rare but potentially devastating condition for surgical patients. While pyoderma gangrenosum has 2 subtypes, typical and atypical, each can be further classified by its heralding features. These include ulcerative, pustular, bullous, and vegetative. The presentation can be a result of trauma or, as mentioned before, postsurgical. The plastic and reconstructive surgeon most likely will encounter postsurgical pyoderma gangrenosum in practice, as it has been reported in patient populations frequently seen in plastic surgery clinics...
2017: Eplasty
https://www.readbyqxmd.com/read/28398589/reducing-the-incidence-of-pressure-ulcers-in-critical-care-units-a-4-year-quality-improvement
#17
Annette Richardson, Joanna Peart, Stephen E Wright, Iain J McCullagh
Quality problem: Critical care patients often have several risk factors for pressure ulceration and implementing prevention interventions have been shown to decrease risk. Initial assessment: We identified a high incidence of pressure ulcers in the four adult critical care units in our organization. Therefore, avoiding pressure ulceration was an important quality priority. Choice of solution: We undertook a quality improvement programme aimed at reducing the incidence of pressure ulceration using an evidence-based bundle approach...
April 7, 2017: International Journal for Quality in Health Care
https://www.readbyqxmd.com/read/28397433/induction-and-maintenance-infliximab-therapy-in-children-with-moderate-to-severe-ulcerative-colitis-retrospective-multicenter-study
#18
Barbara M Iwańczak, Jarosław Kierkuś, Józef Ryżko, Mariusz Szczepanik, Sabina Więcek, Grażyna Czaja-Bulsa, Magdalena Kacperska, Bartosz Korczowski, Jolanta Maślana, Franciszek Iwańczak
BACKGROUND: Pediatric ulcerative colitis (UC) is a severe disease characterised by the presence of extensive inflammatory lesions in the colon. The administration of intravenous corticosteroids is recommended in patients with acute relapse of the disease, whereas early treatment with cyclosporine, tacrolimus or infliximab is recommended if there is no improvement. OBJECTIVES: The aim of this study was to retrospectively evaluate the efficacy and safety of infliximab therapy in the treatment of moderate-to-severe and severe relapse of pediatric UC...
January 2017: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/28395394/patients-perceptions-of-a-pressure-ulcer-prevention-care-bundle-in-hospital-a-qualitative-descriptive-study-to-guide-evidence-based-practice
#19
Shelley Roberts, Marianne Wallis, Elizabeth McInnes, Tracey Bucknall, Merrilyn Banks, Lauren Ball, Wendy Chaboyer
BACKGROUND: Pressure ulcers place a significant burden on patients and hospitals. Our team developed and tested a pressure ulcer prevention care bundle (PUPCB) in a cluster randomized trial. As part of the process evaluation conducted alongside the trial, we explored patients' perceptions of the intervention. AIMS: To identify patients' perceptions and experiences of a PUPCB in hospital. METHODS: This qualitative descriptive study explored the perceptions of a subset of patients who participated in a trial testing the PUPCB across four intervention hospitals...
April 10, 2017: Worldviews on Evidence-based Nursing
https://www.readbyqxmd.com/read/28391412/role-of-mirnas-in-inflammatory-bowel-disease
#20
REVIEW
Bo Cao, Xin Zhou, Jiaojiao Ma, Wei Zhou, Wanli Yang, Daiming Fan, Liu Hong
Inflammatory bowel diseases (IBD), mainly including Crohn's disease and ulcerative colitis, are characterized by chronic inflammation of the gastrointestinal tract. Despite improvements in detection, drug treatment and surgery, the pathogenesis of IBD has not been clarified. A number of miRNAs have been found to be involved in the initiation, development and progression of IBD, and they may have the potential to be used as biomarkers and therapeutic targets. Here, we have summarized the recent advances about the roles of miRNAs in IBD and analyzed the contribution of miRNAs to general diagnosis, differential diagnosis and activity judgment of IBD...
April 8, 2017: Digestive Diseases and Sciences
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