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https://www.readbyqxmd.com/read/28717228/transformation-of-patchouli-alcohol-to-%C3%AE-patchoulene-by-gastric-juice-%C3%AE-patchoulene-is-more-effective-in-preventing-ethanol-induced-gastric-injury
#1
Yuhong Liu, Jiali Liang, Jiazhen Wu, Hanbin Chen, Zhenbiao Zhang, Hongmei Yang, Liping Chen, Haiming Chen, Ziren Su, Yucui Li
Pogostemonis Herba is a functional food approved in Asian countries. Its major constituent, patchouli alcohol (PA), possesses a gastroprotective effect and is reported to transform into β-patchoulene (β-PAE) under acidic conditions. To investigate whether β-PAE, the metabolite of PA, has a protective effect on the gastrointestinal tract, the formation of β-PAE by gastric juice and the anti-ulcerogenic potential of β-PAE against ethanol-induced gastric injury were evaluated. The Results indicated that PA was converted to β-PAE by rat gastric juice...
July 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28712314/angiogenesis-inhibitors-and-symptomatic-anal-ulcers-in-metastatic-colorectal-cancer-patients
#2
Francesca Bergamo, Sara Lonardi, Beatrice Salmaso, Carmelo Lacognata, Francesca Battaglin, Francesco Cavallin, Luca Saadeh, Sabina Murgioni, Antonino Caruso, Camillo Aliberti, Vittorina Zagonel, Carlo Castoro, Marco Scarpa
BACKGROUND: Angiogenesis inhibitors are a standard first-line treatment for metastatic colorectal cancer. Anal canal pain is a common adverse event, but its cause has never been described. The aim of the study was to evaluate the association between the use of angiogenesis inhibitors and symptomatic anal ulcer development. METHODS: This retrospective cohort study included all 601 consecutive metastatic colorectal cancer patients undergoing first line treatment from January 2010 to June 2016 at the Veneto Institute of Oncology...
July 15, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28712194/blocked-coronary-artery-due-to-coronary-spasm-treated-with-stent-insertion-a-sub-optimal-result
#3
Habib Rehman Khan, Sajid Aslam
Myocardial infarction (MI) is an extremely common cause of chest pain. MI can be acute with ST elevation (STEMI) or non-STEMI (NSTEMI). Coronary artery spasm can be severe enough to cause occlusion of the coronary arteries particularly with an exaggerated response in regions of coronary atheroma and plaque ulceration. It is not uncommon for coronary spasm to be mistaken with acute thrombotic occlusion of the coronary artery. We describe a case of a 42-year old man with known cardiac risk factors presents with chest pain for few hours to a tertiary centre hospital...
January 2017: Journal of Ayub Medical College, Abbottabad: JAMC
https://www.readbyqxmd.com/read/28711725/the-cost-effectiveness-of-a-patient-centred-pressure-ulcer-prevention-care-bundle-findings-from-the-intact-cluster-randomised-trial
#4
Jennifer A Whitty, Elizabeth McInnes, Tracey Bucknall, Joan Webster, Brigid M Gillespie, Merrilyn Banks, Lukman Thalib, Marianne Wallis, Jose Cumsille, Shelley Roberts, Wendy Chaboyer
BACKGROUND: Pressure ulcers are serious, avoidable, costly and common adverse outcomes of healthcare. OBJECTIVES: To evaluate the cost-effectiveness of a patient-centred pressure ulcer prevention care bundle compared to standard care. DESIGN: Cost-effectiveness and cost-benefit analyses of pressure ulcer prevention performed from the health system perspective using data collected alongside a cluster-randomised trial. SETTINGS: Eight tertiary hospitals in Australia...
June 27, 2017: International Journal of Nursing Studies
https://www.readbyqxmd.com/read/28711545/antiulcer-properties-of-fruits-and-vegetables-a-mechanism-based-perspective
#5
REVIEW
Choudhary Harsha, Kishore Banik, Devivasha Bordoloi, Ajaikumar B Kunnumakkara
Gastric ulcer is the damage caused to mucosal layer of the stomach under the action of various factors like high levels of acid and pepsin, invasion by Helicobacter pylori, etc. Although most cases have been controlled and the rate of ulcer occurrence has reduced over the last few decades, gastric ulcer still holds a prime concern today. A range of palliative medicines comprising proton pump inhibitors, H2 receptor antagonists, COX-2 inhibitors (coxibs) is widely in use and patients have also been administered with acid suppression therapies...
July 12, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28711030/carvedilol-can-attenuate-histamine-induced-paw-edema-and-formaldehyde-induced-arthritis-in-rats-without-risk-of-gastric-irritation
#6
Faf Sayed Osman, Dina Ahmed Labib, Mahmoud M Kamel
BACKGROUND AND AIM: Rheumatoid arthritis treatment aims to control joint damage and any associated complications such as cardiovascular disease. Most anti-inflammatory drugs have a high tendency to cause gastro-intestinal irritation. The present study is designed to investigate the anti-inflammatory effect of carvedilol and to study its effect on gastric mucosa. EXPERIMENTAL APPROACH: Lornoxicam (1.3mg/kg) or carvedilol (10mg/kg) was administrated orally 1h before histamine injection into animals of a histamine-induced paw edema model and orally daily for 11days into animals of a formaldehyde-induced arthritis model...
July 12, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28708806/understanding-the-cautions-and-contraindications-of-immunomodulator-and-biologic-therapies-for-use-in-inflammatory-bowel-disease
#7
H Matthew Cohn, Maneesh Dave, Edward V Loftus
Ulcerative colitis and Crohn's disease are chronic inflammatory bowel diseases for which there are no cures. These diseases are immunopathogenic, and medical treatment is centered on the temperance of a dysregulated immune response to allow mucosal healing and prevent the sequelae of fistulation and stenosis. Accordingly, the armamentarium of medications, which has expanded immensely in recent history, is not without significant infectious and neoplastic risks. Many of these untoward effects can be mitigated by screening and avoidance of contraindicated medications...
August 2017: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/28708747/footwear-and-insole-design-features-to-prevent-foot-ulceration-in-people-with-diabetes-a-systematic-review-protocol
#8
Richard Collings, Jennifer Freeman, Jos M Latour, Sam Glasser, Joanne Paton
The aim of this systematic review is to identify the key design features of footwear and insoles that are used to offload the plantar surface of the foot to prevent foot ulceration in adults with diabetes.More specifically, the objectives are to identify the key design features of footwear and insoles to offload the plantar surface of the foot with regard to.
July 2017: JBI Database of Systematic Reviews and Implementation Reports
https://www.readbyqxmd.com/read/28705680/characterization-of-significant-molecular-determinants-of-virulence-of-enterovirus-71-sub-genotype-b4-in-rhabdomyosarcoma-cells
#9
Pinn Tsin Isabel Yee, Reham Ahmed Hashim Mohamed, Seng-Kai Ong, Kuan Onn Tan, Chit Laa Poh
One of the leading causes of the hand, foot and mouth disease (HFMD) is Enterovirus 71 (EV-A71), displaying symptoms such as fever and ulcers in children but some strains can produce cardiopulmonary oedema which leads to death. There is no FDA-approved vaccine for prevention of severe HFMD. The molecular determinants of virulence for EV-A71 are unclear. It could be a single or a combination of amino acids that determines virulence in different EV-A71 genotype/sub-genotypes. Several EV-A71 strains bearing single nucleotide (nt) mutations were constructed and the contribution of each mutation to virulence was evaluated...
July 10, 2017: Virus Research
https://www.readbyqxmd.com/read/28704317/comparison-of-collagen-cross-linking-and-amniotic-membrane-transplantation-in-an-experimental-alkali-burn-rabbit-model
#10
Sevgi Subasi, Ozgul Altintas, Melda Yardimoglu, Yusufhan Yazir, Suleyman Karaman, Selenay Furat Rencber, Kubra Kavram
PURPOSE: To compare the effects of collagen cross-linking (CXL) and amniotic membrane transplantation (AMT) on acute corneal alkali burns. METHODS: After establishment of an alkali burn model, 32 rabbits were divided into 4 groups: control group, AMT group, CXL group, and AMT + CXL (combined) group. Clinical parameters, including epithelial wound, opacity, ulceration, and neovascularization, were evaluated on postinjury days 1, 7, 14, and 18. Histological parameters were examined in hematoxylin/eosin (H&E) and Masson trichrome-stained corneal sections...
July 11, 2017: Cornea
https://www.readbyqxmd.com/read/28702982/chronic-inflammation-therapy-combined-with-low-dose-cytokines-in-the-treatment-of-chronic-ulcers-of-lower-limbs
#11
S E Aragona, P Amori, G Mereghetti, J Lotti, T Lotti, G V L Colombo
Prevalence of chronic venous leg ulcers has increased from 55% to 75% in 10 years. We treat chronic vascular lesions according to a cyclic multiphase method that follows the instrumental and differential etiologic diagnosis of ulcers of the lower limbs. The AIMED (Anti Inflammatory Regenerative Medicine) operating model follows the diagnostic phase and is structured in 5 interconnected phases. Mare evaluation, pH control, biofilm removal and prevention and infections are approached according to the International Guidelines...
July 13, 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/28699545/predictive-models-for-pressure-ulcers-from-intensive-care-unit-electronic-health-records-using-bayesian-networks
#12
Pacharmon Kaewprag, Cheryl Newton, Brenda Vermillion, Sookyung Hyun, Kun Huang, Raghu Machiraju
BACKGROUND: We develop predictive models enabling clinicians to better understand and explore patient clinical data along with risk factors for pressure ulcers in intensive care unit patients from electronic health record data. Identifying accurate risk factors of pressure ulcers is essential to determining appropriate prevention strategies; in this work we examine medication, diagnosis, and traditional Braden pressure ulcer assessment scale measurements as patient features. In order to predict pressure ulcer incidence and better understand the structure of related risk factors, we construct Bayesian networks from patient features...
July 5, 2017: BMC Medical Informatics and Decision Making
https://www.readbyqxmd.com/read/28696493/total-contact-cast-system-to-heal-diabetic-foot-ulcers
#13
Brock Liden
Off-loadinga diabetic foot ulcer is a cornerstone of quality wound care for diabetic patients to allow cellular growth in the wound bed. While total contact casts (TCC) have been described as the gold standard for off-loading the wound, the complexity of application and the time commitment for both application and drying have discouraged health professionals from using them. This retrospective case series, conducted in a podiatric practice, evaluated using a TCC system that helps address the three components in which guidelines should be addressed when caring for a diabetic foot: V - vascular management, I - infection management and prevention, and P - pressure relief...
July 11, 2017: Surgical Technology International
https://www.readbyqxmd.com/read/28694849/optimisation-of-rocker-sole-footwear-for-prevention-of-first-plantar-ulcer-comparison-of-group-optimised-and-individually-selected-footwear-designs
#14
Stephen J Preece, Jonathan D Chapman, Bjoern Braunstein, Gert-Peter Brüggemann, Christopher J Nester
BACKGROUND: Appropriate footwear for individuals with diabetes but no ulceration history could reduce the risk of first ulceration. However, individuals who deem themselves at low risk are unlikely to seek out bespoke footwear which is personalised. Therefore, our primary aim was to investigate whether group-optimised footwear designs, which could be prefabricated and delivered in a retail setting, could achieve appropriate pressure reduction, or whether footwear selection must be on a patient-by-patient basis...
2017: Journal of Foot and Ankle Research
https://www.readbyqxmd.com/read/28694758/safety-assessment-and-antioxidant-activity-of-lantana-montevidensis-leaves-contribution-to-its-phytochemical-and-pharmacological-activity
#15
Luiz Marivando Barros, Antonia Eliene Duarte, Emily Pansera Waczuk, Katiane Roversi, Francisco Assis Bezerra da Cunha, Mirian Rolon, Cathia Coronel, Maria Celeste Vega Gomez, Irwin Rose Alencar de Menezes, José Galberto Martins da Costa, Aline Augusti Boligon, Waseem Hassan, Diogo Onofre Souza, João Batista Teixeira da Rocha, Jean Paul Kamdem
Lantana camara, the widely studied species, and L. montevidensis, the less studied species of the genus Lantana are both used in traditional medicine for the same purpose (anti-asthma, anti-ulcer, anti-tumor, etc). However, little is known about the toxicity of L. montevidensis and there is limited information on its chemical constituents. Here, we investigated for the first time the genotoxicity and cytotoxicity of the ethanolic (EtOH) and aqueous extracts from the leaves of Lantana montevidensis in human leukocytes, as well as their possible interaction with human erythrocyte membranes in vitro...
2017: EXCLI journal
https://www.readbyqxmd.com/read/28692781/depression-as-a-risk-factor-of-organic-diseases-an-international-integrative-review
#16
Teodora Bica, Ruth Castelló, Loren L Toussaint, Pilar Montesó-Curto
PURPOSE AND DESIGN: This integrative review offers a systematic synthesis of the international literature regarding the role of depression as a risk factor in physical illnesses and the mechanisms of this connection. Special attention is paid to those modifiable factors. FINDINGS: Published studies of depression and physical illness and disease(N = 24) from five countries that were indexed in PubMed, the Cumulative Index to Nursing and Allied Health Literature (CINAHL), APA PsycNET, Scopus, Dialnet, and CUIDEN were examined...
July 2017: Journal of Nursing Scholarship
https://www.readbyqxmd.com/read/28691461/oral-manifestations-of-selective-iga-deficiency-review-and-case-report
#17
L Azzi, F Croveri, R Vinci, V Maurino, A Boggio, D Mantegazza, D Farronato, A Tagliabue, J Silvestre-Rangil, L Tettamanti
Immunoglobulin A deficiency is the most common primary immunodeficiency defined as decreased serum level of IgA (less than 7 mg/dl) in the presence of normal levels of other immunoglobulin isotypes. Most individuals with IgA deficiency are asymptomatic and identified coincidentally. However, some patients may present with recurrent infections, allergic disorders and autoimmune manifestations, such as diabetes mellitus, Graves disease and celiac disease. The international literature has not produced any kind of review yet about intra-oral manifestations of selective IgA-deficiency...
April 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/28691004/population-knowledge-attitude-and-practice-regarding-helicobacter-pylori-transmission-and-outcomes-a-literature-review
#18
REVIEW
Lisa J Driscoll, Heidi E Brown, Robin B Harris, Eyal Oren
BACKGROUND: Helicobacter pylori infection is associated with the development of chronic gastritis, peptic ulcer disease, and gastric cancer. Current clinical recommendations are that H. pylori test-and-treat should be individualized based on comorbidities and patient preferences among populations at increased risk for certain morbidities. However, knowledge, attitudes and practices regarding H. pylori among potential patient populations are largely unknown. MATERIALS: We conducted a literature review to assess knowledge, attitudes, and practices of patients or community populations around H...
2017: Frontiers in Public Health
https://www.readbyqxmd.com/read/28689520/comparison-of-12-hour-with-72-hour-terlipressin-therapy-for-bleeding-esophageal-varices
#19
Adnan Salim, Kashif Malik, Israr Ul Haq, Arshad Kamal Butt, Altaf Alam
OBJECTIVE: To determine the efficacy of 12-hour of Terlipressin therapy as compared to 72-hour therapy in preventing rebleeding after endoscopic therapy. STUDY DESIGN: Interventional study. PLACE AND DURATION OF STUDY: Department of Gastroenterology and Hepatology, Shaikh Zayed Hospital, Lahore, from January to March 2016. METHODOLOGY: Cirrhotic patients presenting to our hospital with GI (gastrointestinal) bleeding received Terlipressin 2 mg intravenous bolus, followed by 1mg 6-hourly until undergoing endoscopy...
June 2017: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/28687507/gastroprotective-actions-of-taraxacum-coreanum-nakai-water-extracts-in-ethanol-induced-rat-models-of-acute-and-chronic-gastritis
#20
Hye Jeong Yang, Min Jung Kim, Dae Young Kwon, Eun Seon Kang, Suna Kang, Sunmin Park
ETHNOPHARMACOLOGICAL RELEVANCE: Taraxacum coreanum Nakai has been traditionally used for treating inflammatory diseases including gastrointestinal diseases. AIM OF THE STUDY: We studied whether water extracts of Taraxacum coreanum Nakai (TCN) had a protective effect on acute and chronic gastritis induced by ethanol/HCl in an animal model of gastritis and its mechanism was also explored. MATERIALS AND METHODS: In the acute study, rats were orally administered 0...
July 5, 2017: Journal of Ethnopharmacology
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