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https://www.readbyqxmd.com/read/29451600/american-tegumentary-leishmaniasis-diagnostic-and-treatment-challenges-in-a-clinical-case
#1
Jully Oyama, Fabiana Borges Padilha Ferreira, Carolina Cella Conter, Daniele Stéfanie Sara Lopes Lera-Nonose, Áquila Carolina Fernandes Herculano Ramos-Milaré, Eneide Aparecida Sabaini Venazzi, Thaís Gomes Verzignassi Silveira, Maria Valdrinez Campana Lonardoni
This clinical case presents a patient with a raised and ulcerative lesion with erythematous edges in the mouth, on the lower lip that was unsuccessfully treated as herpes labialis. Clinical data and laboratory tests (Montenegro skin test, indirect immunofluorescence, direct parasite search and polymerase chain reaction) led to the diagnosis of American tegumentary leishmaniasis caused by Leishmania (Viannia) sp. Treatment with pentavalent antimonial (Glucantime®) for 120 days was not effective and administration of amphotericin B for 30 days resulted in wound healing...
2018: Revista do Instituto de Medicina Tropical de São Paulo
https://www.readbyqxmd.com/read/29451275/cenegermin-for-the-treatment-of-neurotrophic-keratitis
#2
M Sacchetti, A Bruscolini, A Lambiase
The trigeminal nerve provides corneal sensitivity and trophic supply to corneal tissues. The impairment of corneal innervation leads to development of neurotrophic keratitis (NK). NK is a rare, degenerative corneal disease characterized by corneal hypo/anesthesia and development of nonhealing corneal epithelial defects and ulcers. NK is a challenging condition with high medical need due to the lack of approved treatments that can restore corneal integrity. Current treatment of NK aims at stimulating corneal healing and preventing disease progression...
November 2017: Drugs of Today
https://www.readbyqxmd.com/read/29449960/physician-initiated-clinical-study-of-limb-ulcers-treated-with-a-functional-peptide-sr-0379-from-discovery-to-a-randomized-double-blind-placebo-controlled-trial
#3
Hironori Nakagami, Ken Sugimoto, Takahiro Ishikawa, Taku Fujimoto, Toshifumi Yamaoka, Misa Hayashi, Eiji Kiyohara, Hiroshi Ando, Yuta Terabe, Yoichi Takami, Koichi Yamamoto, Yasushi Takeya, Minoru Takemoto, Masaya Koshizaka, Tamotsu Ebihara, Ayumi Nakamura, Mitsunori Nishikawa, Xiang Jing Yao, Hideki Hanaoka, Ichiro Katayama, Koutaro Yokote, Hiromi Rakugi
SR-0379 is a functional peptide that has wound healing effect with anti-microbial action, making it an ideal drug to prevent infection. To evaluate the safety, efficacy, and pharmacokinetics of SR-0379 for the treatment of leg ulcers, a physician-initiated, phase I/IIa, first-in-patient clinical study was designed. A multi-center, double-blind, randomized clinical study was conducted from October 2015 to September 2016. The inclusion criteria for leg ulcers were (1) diabetes or critical limb ischemia and (2) wound size <6 cm in diameter...
2018: NPJ Aging and Mechanisms of Disease
https://www.readbyqxmd.com/read/29447591/characterization-of-a-partial-body-irradiation-model-with-oral-cavity-shielding-in-non-human-primates
#4
Michael V Accardi, Oreola Donini, Adam Rumage, Alexis Ascah, Julius Haruna, Mylène Pouliot, Kim Bujold, Hai Haung, Wieslaw Wierzbicki, John Stamatopoulos, Houman Naraghi, Thomas Measey, Simon Authier
PURPOSE: Characterization of a novel partial body irradiation (PBI) shielding strategy in nonhuman primates (NHP; rhesus macaques), aimed at protecting the oral cavity, with respect to various gastrointestinal (GI-ARS) syndrome parameters as well as buccal ulceration development. MATERIALS AND METHODS: NHPs were irradiated using a Cobalt-60 gamma source, in a single uniform dose, ranging from 9-13 Gy and delivered at 0.60-0.80 Gy min -1 . Animals were either partially shielded via oral cavity shielding (PBI OS ) or underwent total body irradiation (TBI)...
February 15, 2018: International Journal of Radiation Biology
https://www.readbyqxmd.com/read/29446252/what-is-the-effect-of-exercise-on-wound-healing-in-patients-with-venous-leg-ulcers-a-systematic-review
#5
Daisy Smith, Rebecca Lane, Rosemary McGinnes, Jane O'Brien, Renea Johnston, Lyndal Bugeja, Victoria Team, Carolina Weller
Standard best practice for the treatment of venous leg ulcers (VLUs) is compression bandaging of the lower leg to reduce hydrostatic pressure. There is considerable variation in reported healing rates when using this gold-standard approach; therefore, a systematic and robust evaluation of other interventions is required. Exercise interventions, in addition to standard compression therapy, could improve wound-healing time and prevent their recurrence. We have conducted a systematic review to examine the effects of exercise on wound characteristics, including time to heal, size and recurrence, pain, quality of life, adverse events, and economic outcomes...
February 15, 2018: International Wound Journal
https://www.readbyqxmd.com/read/29446244/systematic-review-of-the-use-of-statistical-process-control-methods-to-measure-the-success-of-pressure-ulcer-prevention
#6
Michael Clark, Trudie Young, Maureen Fallon
Successful prevention of pressure ulcers is the end product of a complex series of care processes including, but not limited to, the assessment of vulnerability to pressure damage; skin assessment and care; nutritional support; repositioning; and the use of beds, mattresses, and cushions to manage mechanical loads on the skin and soft tissues. The purpose of this review was to examine where and how Statistical Process Control (SPC) measures have been used to assess the success of quality improvement initiatives intended to improve pressure ulcer prevention...
February 15, 2018: International Wound Journal
https://www.readbyqxmd.com/read/29440893/nanoemulsion-as-a-strategy-for-improving-the-oral-bioavailability-and-anti-inflammatory-activity-of-andrographolide
#7
Ching-Chi Yen, Yi-Chen Chen, Ming-Tsang Wu, Chia-Chi Wang, Yu-Tse Wu
Background: Andrographolide (AG), a compound with low water solubility, possesses various pharmacological activities, particularly anti-inflammatory activity. However, its low oral bioavailability is a major obstacle to its potential use. This study developed and optimized an AG-loaded nanoemulsion (AG-NE) formulation to improve AG oral bioavailability and its protective effects against inflammatory bowel disease. Methods: A high-pressure homogenization technique was used to prepare the AG-NE and solubility, viscosity, and droplet size tests were conducted to develop the optimized AG-NE composed of α-tocopherol, ethanol, Cremophor EL, and water...
2018: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29439130/limb-and-person-level-risk-factors-for-lower-limb-amputation-in-the-prospective-seattle-diabetic-foot-study
#8
Edward J Boyko, Amber D Seelig, Jessie H Ahroni
OBJECTIVE: Diabetes is the leading cause of nontraumatic lower-limb amputations in the U.S., but no research has prospectively examined associations between limb-specific measurements and amputation risk among patients without foot ulcer. We investigated amputation risk by limb in relation to the same limb- and person-level factors. RESEARCH DESIGN AND METHODS: We conducted a 22-year prospective study among 1,461 male patients with diabetes without foot ulcer (mean age 62...
February 8, 2018: Diabetes Care
https://www.readbyqxmd.com/read/29438149/100-years-of-bedsores-how-much-have-we-learned
#9
Jeffrey M Levine
Just over 100 years ago, an article was published describing a plan to treat decubitus ulcers that can shed light upon medical progress and current practices. Key prevention and treatment elements included a dedicated ward, staff continuity, frequent position changes and special surfaces, cleanliness, disinfectants, and dressing changes. The necessity of resource allocation and interdisciplinary collaboration was acknowledged. This article sheds light on not only how much we have learned, but also how far we have to go...
March 2018: Advances in Skin & Wound Care
https://www.readbyqxmd.com/read/29436796/predictive-value-of-braden-risk-factors-in-pressure-ulcers-of-outpatients-with-spinal-cord-injury
#10
Fariba Sadeghi Fazel, Nazi Derakhshanrad, Mir Saeed Yekaninejad, Fardis Vosoughi, Asal Derakhshanrad, Hooshang Saberi
Pressure Ulcers (PUs) remain among the most common complications after traumatic spinal cord Injuries (SCIs). The main goal of risk factor assessment with different tools has been to provisionally estimate the chance of developing pressure ulcers in patients with Spinal Cord Injury (SCI). Braden tool has been of good predictive value and most commonly employed in hospital communities for risk assessment of pressure sore development. The objective of this study was to determine the Braden risk factors as well as the prevalence of pressure injuries in SCI patients...
January 2018: Acta Medica Iranica
https://www.readbyqxmd.com/read/29430403/adverse-events-in-critical-care-search-and-active-detection-through-the-trigger-tool
#11
Francisco J Molina, Paula T Rivera, Alejandro Cardona, Diana C Restrepo, Oralia Monroy, Daniel Rodas, Juan G Barrientos
AIM: To investigate the incidence of disadvantageous events by using the Global Trigger Tool in an intensive care unit (ICU). METHODS: A retrospective descriptive study was performed in a 12-bed university ICU in the city of Medellin, Colombia. Clinical charts of hospitalized patients were reviewed, between January 1 and December 31, 2016, with the following inclusion criteria: subjects aged over 18 years, with at least 24 h of hospitalization and who had a complete medical history that could be accessed...
February 4, 2018: World Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/29427831/australian-nursing-students-knowledge-and-attitudes-towards-pressure-injury-prevention-a-cross-sectional-study
#12
Kim Usher, Cindy Woods, Janie Brown, Tamara Power, Jackie Lea, Marie Hutchinson, Carey Mather, Andrea Miller, Annette Saunders, Jane Mills, Lin Zhao, Karen Yates, Marie Bodak, Joanne Southern, Debra Jackson
AIM: The aim of this study was to assess student nurses' knowledge of and attitudes towards pressure injury prevention evidence-based guidelines. BACKGROUND: Pressure injuries are a substantial problem in many healthcare settings causing major harm to patients, and generating major economic costs for health service providers. Nurses have a crucial role in the prevention of pressure injuries across all health care settings. DESIGN: A multi-centered, cross-sectional study was conducted using a paper-based questionnaire with undergraduate nursing students enrolled in seven universities with campuses across five Australian states (Queensland, New South Wales, Western Australia, Victoria and Tasmania)...
February 2, 2018: International Journal of Nursing Studies
https://www.readbyqxmd.com/read/29422809/fecal-microbiota-transplantation-for-recurrent-clostridium-difficile-infection-in-a-patient-with-ulcerative-colitis
#13
Kosaku Nanki, Shinta Mizuno, Katsuyoshi Matsuoka, Keiko Ono, Shinya Sugimoto, Hiroki Kiyohara, Mari Arai, Moeko Nakashima, Kozue Takeshita, Keiichiro Saigusa, Mitsutoshi Senoh, Tadashi Fukuda, Makoto Naganuma, Haru Kato, Wataru Suda, Masahira Hattori, Takanori Kanai
Fecal microbiota transplantation (FMT) has been reported as a safe and effective therapy in patients with refractory and recurrent Clostridium difficile infection (CDI). FMT has also been reported as a promising therapy in patients with ulcerative colitis (UC). Both, CDI and UC, are believed to be caused by dysbiosis, such as altered compositions or decreased diversity of the intestinal microbiota. This report describes a patient with UC in remission with a second recurrent episode of CDI, who was treated with FMT...
January 2018: Intestinal Research
https://www.readbyqxmd.com/read/29419849/braf-v600-mutation-profile-of-metastatic-melanoma-in-the-thrace-region-of-turkey
#14
Nuray Can, Ebru Taştekin, Tülin Deniz Yalta, Necdet Süt, Selma Korkmaz, Ufuk Usta, Fulya Öz Puyan, Ezgi Genç, Mert Cezik, Busem Binboğa Tutuğ, Osman Köstek, Hilmi Tozkir
OBJECTIVE: BRAF is the most common mutation in melanoma. The most common subtype is BRAF V600E, followed by V600K. Initially, the authors aimed to investigate whether clinicopathological features of melanoma are associated with BRAF mutations. We then aimed to present the relationships between the clinicopathological features and the mutated subtype (V600E vs V600K). MATERIAL AND METHOD: 61 patients with metastatic malignant melanoma (affecting the lymph node or other distant sites) were selected...
February 8, 2018: Türk Patoloji Dergisi
https://www.readbyqxmd.com/read/29419369/risks-and-prevalence-of-pressure-ulcers-among-patients-in-an-acute-hospital-in-finland
#15
Marita Koivunen, Anna Hjerppe, Eija Luotola, Tommi Kauko, Paula Asikainen
OBJECTIVE: To quantify pressure ulcer (PU) prevalence and to describe and identify the PU risk factors in acute hospital wards. METHOD: A descriptive quantitative study was performed in 13 wards in a central hospital in Finland. The study included PU risk evaluation using the Braden risk assessment method, and full skin and medical assessment of consenting adult patients. Patients in paediatric, maternity and psychiatric wards, and in the intensive care unit were excluded...
February 1, 2018: Journal of Wound Care
https://www.readbyqxmd.com/read/29415150/kaempferol-protects-ethanol-induced-gastric-ulcers-in-mice-via-pro-inflammatory-cytokines-and-no
#16
Qinchen Li, Xinxin Hu, Yanhan Xuan, Jianghua Ying, Yujia Fei, Jielu Rong, Yong Zhang, Jian Zhang, Chunyan Liu, Zheng Liu
Gastric ulcers (GUs) are common pathologies that affect many people around the world. Excessive alcohol consumption is one of the main causes of GUs; however, there are still lack of effective drugs for the prevention or therapy of GUs. In this study, we evaluated the protective effects and possible mechanisms of kaempferol (KAE) against acute ethanol-induced lesions to the gastric mucosa in mice. Fasted mice were orally given vehicle (0.9% saline), omeprazole (20 mg/kg), or KAE (40, 80, or 160 mg/kg) for 1 h in different experimental sets prior to the establishment of the GU model by challenge with absolute ethanol (10 ml/kg)...
February 3, 2018: Acta Biochimica et Biophysica Sinica
https://www.readbyqxmd.com/read/29410772/the-abrupt-temperature-changes-in-the-plantar-skin-thermogram-of-the-diabetic-patient-looking-in-to-prevent-the-insidious-ulcers
#17
REVIEW
Francisco-J Renero-C
Background: One of the complications of the diabetes mellitus is the amputation of the lower limbs. This complication may be developed after an insidious ulcer, that may be raised by the peripheral neuropathy or the ischaemic limb, and that the ulcer get infected. That is, to develop an ulcer, in the diabetic patient, three factors should be taken into the account, the autonomic nervous system, the blood supply and the inmune system. Methods: In this work, the thermogram is used to identify regions on the plantar skin with blood supply deficiencies and the behaviour of the thermoregulation process...
2018: Diabetic Foot & Ankle
https://www.readbyqxmd.com/read/29410309/gastroprotective-effects-of-hwanglyeonhaedok-tang-against-helicobacter-pylori-induced-gastric-cell-injury
#18
Hee-Seon Park, Charith Ub Wijerathne, Hye-Yun Jeong, Chang-Seob Seo, Hyekyung Ha, Hyo-Jung Kwun
ETHNOPHARMACOLOGICAL RELEVANCE: Helicobacter pylori, which is found in the stomachs of approximately half of the world's population, has been associated with the development of chronic gastritis and gastric cancer. Hwanglyeonhaedok-tang (HHT) is a popular traditional medicine for the therapies of gastric ulcers and gastritis. AIM OF THE STUDY: The emerging resistance of H. pylori to antibiotics arouses requirement on alternative nonantibiotic-based therapies. In the present study, we investigated the anti-inflammatory activity and anti-microbial activity of HHT against H...
February 1, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29406201/proton-pump-inhibitors-review-of-emerging-concerns
#19
REVIEW
Avinash K Nehra, Jeffrey A Alexander, Conor G Loftus, Vandana Nehra
First introduced in 1989, proton pump inhibitors (PPIs) are among the most widely utilized medications worldwide, both in the ambulatory and inpatient clinical settings. The PPIs are currently approved by the US Food and Drug Administration for the management of a variety of gastrointestinal disorders including symptomatic peptic ulcer disease, gastroesophageal reflux disease, and nonulcer dyspepsia as well as for prevention of gastrointestinal bleeding in patients receiving antiplatelet therapy. PPIs inhibit gastric acid secretion, and the most commonly associated adverse effects include abdominal pain, diarrhea, and headache...
February 2018: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/29404920/management-of-anemia-in-patients-with-inflammatory-bowel-disease-ibd
#20
REVIEW
Dhruvan Patel, Chinmay Trivedi, Nabeel Khan
PURPOSE OF REVIEW: Anemia is the most common complication as well as an extra intestinal manifestation of inflammatory bowel disease (IBD). It is associated with a significant impact on patient's quality of life (QoL); as well it represents a common cause of frequent hospitalization, delay of hospital inpatient discharge and overall increased healthcare burden. In spite of all these, anemia is still often underdiagnosed and undertreated. Our aim in this review is to provide a pathway for physicians to help them achieve early diagnosis as well as timely and appropriate treatment of anemia which in turn would hopefully reduce the prevalence and subsequent complications of this condition among IBD patients...
February 5, 2018: Current Treatment Options in Gastroenterology
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