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https://www.readbyqxmd.com/read/28734803/distribution-of-kir-genes-and-kir2ds4-gene-variants-in-two-mexican-mestizo-populations
#1
Machado-Sulbaran Andrea Carolina, Muñoz-Valle José Francisco, Ramírez-Dueñas María Guadalupe, Baños-Hernández Christian Johana, Machuca-Graciano Omar, Velarde-De la Cruz Erandi Enif, Parra-Rojas Isela, Sánchez-Hernández Pedro Ernesto
Killer immunoglobulin-like receptors (KIR) are transmembrane proteins that regulate NK and T cell subsets by recognizing HLA-I molecules as ligands. The KIR gene family consists of 16 genes, located at chromosome 19q13.4. KIR gene frequencies vary among populations. In Mexico, HLA and genetic ancestry studies show that Mestizo populations have different genetic backgrounds based on admixture with European, African, and Asian ancestry. This study aimed to evaluate the frequencies of KIR genes and genotypes in Guerrero and Jalisco, two Mexican Mestizo populations located in the south and the west of the country, respectively, and to compare these frequencies with those of other populations...
July 19, 2017: Human Immunology
https://www.readbyqxmd.com/read/28734764/comparative-genomic-analysis-of-mycobacterium-tuberculosis-beijing-like-strains-revealed-specific-genetic-variations-associated-with-virulence-and-drug-resistance
#2
Juan Germán Rodríguez-Castillo, Camilo Pino, Luis Fernando Niño, Juan Carlos Rozo, Claudia Llerena-Polo, Carlos A Parra-López, Andreas Tauch, Martha Isabel Murcia-Aranguren
Isolates of the Mycobacterium tuberculosis lineage 2/East-Asian are considered one of the most successful strains due to their increased pathogenicity, hyper-virulence associated with drug resistance, and high transmission. Recent studies in Colombia have shown that the Beijing-like genotype is associated with multidrug-resistance and high prevalence in the southwest of the country, but the genetic basis of its success in dissemination is unknown. In contribution to this matter, we obtained the whole sequences of six genomes of clinical isolates assigned to the Beijing-like genotype...
July 19, 2017: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/28733428/tcr-repertoire-intratumor-heterogeneity-in-localized-lung-adenocarcinomas-an-association-with-predicted-neoantigen-heterogeneity-and-postsurgical-recurrence
#3
Alexandre Reuben, Rachel M Gittelman, Jianjun Gao, Jiexin Zhang, Erik Yusko, Chang-Jiun Wu, Ryan Emerson, Jianhua Zhang, Christopher M Tipton, Jun Li, Kelly Quek, Vancheswaran Gopalakrishnan, Runzhe Chen, Luis Vence, Tina Cascone, Marissa Vignali, Junya Fujimoto, Jaime Rodriguez-Canales, Edwin R Parra, Latasha D Little, Curtis Gumbs, Marie-Andrée Forget, Lorenzo Federico, Cara Haymaker, Carmen Behrens, Sharon Benzeno, Chantale Bernatchez, Boris Sepesi, Don L Gibbons, Jennifer A Wargo, William N William, Stephen G Swisher, John Heymach, Harlan Robins, J Jack Lee, Padmanee Sharma, James P Allison, P Andrew Futreal, Ignacio I Wistuba, Jianjun Zhang
Genomic intratumor heterogeneity (ITH) may be associated with postsurgical relapse of localized lung adenocarcinomas. Recently, mutations, through generation of neoantigens were shown to alter tumor immunogenicity through T cell responses. Here, we performed sequencing of the T cell receptor (TCR) in 45 tumor regions from 11 localized lung adenocarcinomas and observed substantial intratumor differences in T cell density and clonality with the majority of T cell clones restricted to individual tumor regions...
July 21, 2017: Cancer Discovery
https://www.readbyqxmd.com/read/28731050/genomic-abnormalities-in-invasive-endocervical-adenocarcinoma-correlate-with-pattern-of-invasion-biologic-and-clinical-implications
#4
Anjelica Hodgson, Yutaka Amemiya, Arun Seth, Matthew Cesari, Bojana Djordjevic, Carlos Parra-Herran
The pattern-based classification system for HPV-related endocervical adenocarcinoma, which classifies tumors based on the destructiveness of stromal invasion, is predictive of the risk of nodal metastases and adverse outcome. Previous studies have demonstrated clinically important molecular alterations in endocervical adenocarcinoma, including KRAS and PIK3CA mutations; however, correlation between the molecular landscape and pathological variables including pattern of invasion has not been thoroughly explored...
July 21, 2017: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/28721336/post-endovascular-aneurysm-repair-evar-testicular-ischemia-a-rare-complication
#5
Eric Thomas, Brett L Parra, Shonak Patel
Endovascular aneurysm repair (EVAR) is a common modality of treating abdominal aortic aneurysms (AAA). Common complications include endoleak, bleeding, infection, contrast related injuries, and ischemia. We present the case of a patient who experienced a testicular infarction following repair of an infrarenal AAA. We also discuss the implications for this complication and review the available literature for similar cases and treatment options.
September 2017: Urology Case Reports
https://www.readbyqxmd.com/read/28719380/comparison-of-different-antibody-clones-for-immunohistochemistry-detection-of-programmed-cell-death-ligand-1-pd-l1-on-non-small-cell-lung-carcinoma
#6
Edwin R Parra, Pamela Villalobos, Barbara Mino, Jaime Rodriguez-Canales
Programmed cell death ligand 1 (PD-L1) is a major immune checkpoint protein that mediates antitumor immune suppression and response. Preliminary data suggest that its detection using immunohistochemistry (IHC) in formalin-fixed and paraffin-embedded tissues may predict clinical response to PD-1/PD-L1 therapy. In diagnostic pathology, it is essential to count with a validated IHC that can reliably detect PD-L1-positive cases. The present study was conducted to compare and validate different PD-L1 commercial clones and identify which ones can be reliably used by surgical pathologist to detect PD-L1 expression in human cancer tissues...
July 17, 2017: Applied Immunohistochemistry & Molecular Morphology: AIMM
https://www.readbyqxmd.com/read/28717202/%C3%AE-caryophyllene-emitted-from-a-transgenic-arabidopsis-or-chemical-dispenser-repels-diaphorina-citri-vector-of-candidatus-liberibacters
#7
Berta Alquézar, Haroldo Xavier Linhares Volpe, Rodrigo Facchini Magnani, Marcelo Pedreira de Miranda, Mateus Almeida Santos, Nelson Arno Wulff, Jose Mauricio Simões Bento, José Roberto Postali Parra, Harro Bouwmeester, Leandro Peña
Production of citrus, the main fruit tree crop worldwide, is severely threatened by Huanglongbing (HLB), for which as yet a cure is not available. Spread of this bacterial disease in America and Asia is intimately connected with dispersal and feeding of the insect vector Diaphorina citri, oligophagous on rutaceous host plants. Effective control of this psyllid is an important component in successful HLB management programs. Volatiles released from the non-host guava have been shown to be repellent to the psyllid and to inhibit its response to citrus odour...
July 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28715387/a-modified-trier-social-stress-test-for-vulnerable-mexican-american-adolescents
#8
Megan M Johnson, Julianna Deardorff, Kimberly Parra, Abbey Alkon, Brenda Eskenazi, Elizabeth Shirtcliff
The Trier Social Stress Test (TSST) is a well validated and widely used social stressor that has been shown to induce a 2-4 fold increase in cortisol, the biological output produced by the Hypothalamic-Pituitary-Adrenal (HPA) axis in humans. While studies have explored how modifications to the TSST influence stress responsivity, few studies have created a modified TSST appropriate for vulnerable youth that elicits a significant cortisol stress response. Thus, the current study sought to modify or adjust the TSST in a culturally sensitive way for a vulnerable sample of 14 year-old adolescents...
July 10, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28715362/resuscitative-endovascular-balloon-occlusion-of-the-aorta-for-placenta-percreta-previa
#9
Michael W Parra, Carlos Alberto Ordonez, Juan P Herrera-Escobar, Adolfo Gonzalez-Garcia, Jon Guben
No abstract text is available yet for this article.
July 15, 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28714849/proposal-for-a-unified-classification-system-and-nomenclature-of-lagoviruses
#10
Jacques Le Pendu, Joana Abrantes, Stéphane Bertagnoli, Jean-Sébastien Guitton, Ghislaine Le Gall-Reculé, Ana Margarida Lopes, Stéphane Marchandeau, Fernando Alda, Tereza Almeida, Alves Paulo Célio, Juan Bárcena, Galina Burmakina, Esther Blanco, Carlos Calvete, Patrizia Cavadini, Brian Cooke, Kevin Dalton, Miguel Delibes Mateos, Wieslaw Deptula, John Sebastian Eden, Fang Wang, Catarina C Ferreira, Paula Ferreira, Pilar Foronda, David Gonçalves, Dolores Gavier-Widén, Robin Hall, Beata Hukowska-Szematowicz, Peter Kerr, John Kovaliski, Antonio Lavazza, Jackie Mahar, Alexander Malogolovkin, Raquel M Marques, Sara Marques, Aaron Martin-Alonso, Pedro Monterroso, Sacramento Moreno, Greg Mutze, Aleksija Neimanis, Paulina Niedzwiedzka-Rystwej, David Peacock, Francisco Parra, Mara Rocchi, Carlos Rouco, Nathalie Ruvoën-Clouet, Eliane Silva, Diogo Silvério, Tanja Strive, Gertrudes Thompson, Beata Tokarz-Deptula, Pedro Esteves
Lagoviruses belong to the Caliciviridae family. They were first recognized as highly pathogenic viruses of the European rabbit (Oryctolagus cuniculus) and European brown hare (Lepus europaeus) that emerged in the 1970-1980s, namely, rabbit haemorrhagic disease virus (RHDV) and European brown hare syndrome virus (EBHSV), according to the host species from which they had been first detected. However, the diversity of lagoviruses has recently expanded to include new related viruses with varying pathogenicity, geographic distribution and host ranges...
July 17, 2017: Journal of General Virology
https://www.readbyqxmd.com/read/28713719/stacked-pap-flaps-for-two-stage-immediate-bilateral-breast-reconstruction-a-case-report
#11
Luis Parra
No abstract text is available yet for this article.
May 2017: World Journal of Plastic Surgery
https://www.readbyqxmd.com/read/28709859/recurrent-cardiac-fibroelastoma-is-it-really-a-benign-tumor
#12
Belén Díaz-Antón, Ángel González Pinto, Francisco Javier Parra Jiménez, Gregorio Cuerpo Caballero, Francisco Pérez Rodríguez, Jorge Solís Martín
No abstract text is available yet for this article.
July 11, 2017: Revista Española de Cardiología
https://www.readbyqxmd.com/read/28708609/evaluation-of-nutrients-removal-no3-n-nh3-n-and-po4-p-with-chlorella-vulgaris-pseudomonas-putida-bacillus-cereus-and-a-consortium-of-these-microorganisms-in-the-treatment-of-wastewater-effluents
#13
Abril Gómez-Guzmán, Sergio Jiménez-Magaña, A Suggey Guerra-Rentería, César Gómez-Hermosillo, F Javier Parra-Rodríguez, Sergio Velázquez, Blanca Rosa Aguilar-Uscanga, Josue Solis-Pacheco, Orfil González-Reynoso
In this research removal of NH3-N, NO3-N and PO4-P nutrients from municipal wastewater was studied, using Chlorella vulgaris, Pseudomonas putida, Bacillus cereus and an artificial consortium of them. The objective is to analyze the performance of these microorganisms and their consortium, which has not been previously studied for nutrient removal in municipal wastewater. A model wastewater was prepared simulating the physicochemical characteristics found at the wastewater plant in Chapala, Mexico. Experiments were carried out without adding an external carbon source...
July 2017: Water Science and Technology: a Journal of the International Association on Water Pollution Research
https://www.readbyqxmd.com/read/28707490/transferon%C3%A2-a-peptide-mixture-with-immunomodulatory-properties-is-not-immunogenic-when-administered-with-various-adjuvants
#14
Sandra Avila, Leslie Muñoz-García, Said Vázquez-Leyva, Nohemí Salinas-Jazmín, Emilio Medina-Rivero, Lenin Pavón, Gabriela Mellado-Sánchez, Rommel Chacón-Salinas, Sergio Estrada-Parra, Luis Vallejo-Castillo, Sonia Mayra Pérez-Tapia
Transferon, a human dialyzable leukocyte extract (hDLE), is a biotherapeutic that comprises a complex mixture of low-molecular-weight peptides (< 10 kDa) and is used to treat diseases with an inflammatory component. Some biotherapeutics, including those composed of peptides, can induce anti-drug antibodies (ADA) that block or diminish their therapeutic effect. Nevertheless, few studies have evaluated peptide-derived drug immunogenicity. In this study, the immunogenicity of Transferon was examined in a murine model during an immunization scheme using the following adjuvants: Al(OH)3, incomplete Freund's adjuvant (IFA), or Titermax Gold...
December 2017: Journal of Immunotoxicology
https://www.readbyqxmd.com/read/28707293/coronary-septic-embolism-an-unusual-presentation-of-acute-myocardial-infarction
#15
Eusebio García-Izquierdo, Marta Jiménez-Blanco, Carolina Parra Esteban, Javier Ortega Marcos
No abstract text is available yet for this article.
2017: Kardiologia Polska
https://www.readbyqxmd.com/read/28706771/an-unusual-case-of-bilateral-anterior-uveitis-related-to-moxifloxacin-the-first-report-in-latin-america
#16
Carlos M Rangel, M Margarita Parra, Gabriel Frederick, Alejandro Tello, Clara L Varón
Objective: To report a case of bilateral anterior uveitis secondary to oral moxifloxacin. Methods: Case report. Results: A 54-year-old female presented bilateral anterior uveitis following a 10-day course of oral moxifloxacin. She developed a bilateral anterior uveitis associated with pigment dispersion syndrome and iris transillumination. Conclusions: Drug-induced uveitis is one of the causes of anterior uveitis. Uveitis related to fluoroquinolones is a rare entity, there are few cases reported in the literature, this is the first case reported in Latin America...
2017: GMS Ophthalmology Cases
https://www.readbyqxmd.com/read/28706527/localization-of-sphingolipid-enriched-plasma-membrane-regions-and-long-chain-base-composition-during-mature-fruit-abscission-in-olive
#17
Maria C Parra-Lobato, Miguel A Paredes, Juana Labrador, Mariana Saucedo-García, Marina Gavilanes-Ruiz, Maria C Gomez-Jimenez
Sphingolipids, found in membranes of eukaryotic cells, have been demonstrated to carry out functions in various processes in plant cells. However, the roles of these lipids in fruit abscission remain to be determined in plants. Biochemical and fluorescence microscopy imaging approach has been adopted to investigate the accumulation and distribution of sphingolipids during mature-fruit abscission in olive (Olea europaea L. cv. Picual). Here, a lipid-content analysis in live protoplasts of the olive abscission zone (AZ) was made with fluorescent dyes and lipid analogs, particularly plasma membrane sphingolipid-enriched domains, and their dynamics were investigated in relation to the timing of mature-fruit abscission...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28705374/-relevance-of-the-socioeconomic-and-health-context-in-patient-satisfaction
#18
Shirley Pérez-Romero, Juan J Gascón-Cánovas, Diego Salmerón-Martínez, Pedro Parra-Hidalgo, Olga Monteagudo-Piqueras
OBJECTIVE: To determine which factors of the socioeconomic and health contexts influence the perception of the satisfaction of the population with the health services. METHODS: The data come from the European Health Survey of 2009. In the 22,188 subjects surveyed, the relationship between the perception of satisfaction with the health services received and the individual and contextual variables was studied, applying a multilevel analysis. RESULTS: The factors of the socioeconomic and health contexts that influence satisfaction are: higher rates of low level of studies where the perception of excellence is less likely (odds ratio [OR]: 0...
July 11, 2017: Gaceta Sanitaria
https://www.readbyqxmd.com/read/28705187/analysis-of-home-based-rehabilitation-in-patients-with-motor-impairment-in-primary-care-a-prospective-observational-study
#19
Francisco Antonio Vega-Ramírez, Remedios López-Liria, Genoveva Granados-Gámez, Jose Manuel Aguilar-Parra, David Padilla-Góngora
BACKGROUND: The purpose of health and social policies is to encourage older people more longevity, remain free of disability and experience quality of life while living in their homes. The aim of this study was to describe the characteristics of 473 patients diagnosed with motor impairment in primary care, the objectives of home-based rehabilitation and its functional impact. METHODS: This prospective observational study was conducted in the Almería Health District...
July 14, 2017: BMC Geriatrics
https://www.readbyqxmd.com/read/28701967/a-novel-integrating-virtual-reality-approach-for-the-assessment-of-the-attachment-behavioral-system
#20
Irene Alice Chicchi Giglioli, Gabriella Pravettoni, Dolores Lucia Sutil Martín, Elena Parra, Mariano A Raya
Virtual reality (VR) technology represents a novel and powerful tool for behavioral research in psychological assessment. VR provides simulated experiences able to create the sensation of undergoing real situations. Users become active participants in the virtual environment seeing, hearing, feeling, and actuating as if they were in the real world. Currently, the most psychological VR applications concern the treatment of various mental disorders but not the assessment, that it is mainly based on paper and pencil tests...
2017: Frontiers in Psychology
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