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https://www.readbyqxmd.com/read/28327558/actomyosin-generated-tension-on-cadherin-is-similar-between-dividing-and-non-dividing-epithelial-cells-in-early-xenopus-laevis-embryos
#1
Gaëtan Herbomel, Guillaume Hatte, Julien Roul, Sergi Padilla-Parra, Jean-Pierre Tassan, Marc Tramier
Epithelia represent a unique situation where polarized cells must maintain sufficiently strong cell-cell contacts to guarantee the epithelial integrity indispensable for barrier functions. Nevertheless, epithelia must also keep sufficient plasticity which is crucial during development and morphogenesis. Adherens junctions and mechanical forces produced by the actomyosin cytoskeleton are major players for epithelial integrity maintenance and plasticity regulations. To understand how the epithelium is able to meet such a challenge, it is indispensable to determine how cellular junctions and mechanical forces acting at adherens junctions are regulated...
March 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28324847/species-identification-in-forensic-samples-using-the-spindel-approach-a-ghep-isfg-inter-laboratory-collaborative-exercise
#2
Cíntia Alves, Rui Pereira, Lourdes Prieto, Mercedes Aler, Cesar R L Amaral, Cristina Arévalo, Gabriela Berardi, Florencia Di Rocco, Mariela Caputo, Cristian Hernandez Carmona, Laura Catelli, Heloísa Afonso Costa, Pavla Coufalova, Sandra Furfuro, Óscar García, Anibal Gaviria, Ana Goios, Juan José Builes Gómez, Alexis Hernández, Eva Del Carmen Betancor Hernández, Luís Miranda, David Parra, Susana Pedrosa, Maria João Anjos Porto, Maria de Lurdes Rebelo, Matteo Spirito, María Del Carmen Villalobos Torres, António Amorim, Filipe Pereira
DNA is a powerful tool available for forensic investigations requiring identification of species. However, it is necessary to develop and validate methods able to produce results in degraded and or low quality DNA samples with the high standards obligatory in forensic research. Here, we describe a voluntary collaborative exercise to test the recently developed Species Identification by Insertions/Deletions (SPInDel) method. The SPInDel kit allows the identification of species by the generation of numeric profiles combining the lengths of six mitochondrial ribosomal RNA (rRNA) gene regions amplified in a single reaction followed by capillary electrophoresis...
March 7, 2017: Forensic Science International. Genetics
https://www.readbyqxmd.com/read/28319700/soil-organic-carbon-distribution-in-mediterranean-areas-under-a-climate-change-scenario-via-multiple-linear-regression-analysis
#3
Alfonso Olaya-Abril, Luis Parras-Alcántara, Beatriz Lozano-García, Rafael Obregón-Romero
Over time, the interest on soil studies has increased due to its role in carbon sequestration in terrestrial ecosystems, which could contribute to decreasing atmospheric CO2 rates. In many studies, independent variables were related to soil organic carbon (SOC) alone, however, the contribution degree of each variable with the experimentally determined SOC content were not considered. In this study, samples from 612 soil profiles were obtained in a natural protected (Red Natura 2000) of Sierra Morena (Mediterranean area, South Spain), considering only the topsoil 0-25cm, for better comparison between results...
March 15, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28318784/kinetics-of-endogenous-camkii-required-for-synaptic-plasticity-revealed-by-optogenetic-kinase-inhibitor
#4
Hideji Murakoshi, Myung Eun Shin, Paula Parra-Bueno, Erzsebet M Szatmari, Akihiro C E Shibata, Ryohei Yasuda
Elucidating temporal windows of signaling activity required for synaptic and behavioral plasticity is crucial for understanding molecular mechanisms underlying these phenomena. Here, we developed photoactivatable autocamtide inhibitory peptide 2 (paAIP2), a genetically encoded, light-inducible inhibitor of CaMKII activity. The photoactivation of paAIP2 in neurons for 1-2 min during the induction of LTP and structural LTP (sLTP) of dendritic spines inhibited these forms of plasticity in hippocampal slices of rodents...
March 8, 2017: Neuron
https://www.readbyqxmd.com/read/28303951/enhancing-the-sensitivity-of-magnetic-sensors-by-3d-metamaterial-shells
#5
Carles Navau, Rosa Mach-Batlle, Albert Parra, Jordi Prat-Camps, Sergi Laut, Nuria Del-Valle, Alvaro Sanchez
Magnetic sensors are key elements in our interconnected smart society. Their sensitivity becomes essential for many applications in fields such as biomedicine, computer memories, geophysics, or space exploration. Here we present a universal way of increasing the sensitivity of magnetic sensors by surrounding them with a spherical metamaterial shell with specially designed anisotropic magnetic properties. We analytically demonstrate that the magnetic field in the sensing area is enhanced by our metamaterial shell by a known factor that depends on the shell radii ratio...
March 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28298674/using-high-hydrostatic-pressures-to-retain-the-antioxidant-compounds-and-to-reduce-the-enzymatic-activity-of-a-pitaya-pineapple-stenocereus-sp-fragaria-ananassa-beverage
#6
Luisaldo Sandate-Flores, Magdalena de J Rostro-Alanis, Elena Ivonne Mancera-Andrade, Diego A Esquivel-Hernandez, Carlos Brambila-Paz, Roberto Parra-Saldívar, Jorge Welti-Chanes, Zamantha Escobedo-Avellaneda, José Rodríguez-Rodríguez
Pitaya (Stenocereus sp.) is a fruit native to arid and semiarid areas of Mexico. It has high antioxidant activity mainly due to its contents of betalains and phenolics, but its consumption is limited due to very short shelf-life and not very recognized flavor. A beverage of pitaya and pineapple was formulated to improve sensory properties. A high hydrostatic pressure (HHP) study at 400-600 MPa and 25 °C for 2-10 min was applied in the beverage and the effect on the contents of vitamin C, total phenolics and betalains, and the pectin methylesterase (PME) activity of pitaya-pineapple beverages, was evaluated...
March 2017: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/28297869/front-interaction-induces-excitable-behavior
#7
P Parra-Rivas, M A Matías, P Colet, L Gelens, D Walgraef, D Gomila
Spatially extended systems can support local transient excitations in which just a part of the system is excited. The mechanisms reported so far are local excitability and excitation of a localized structure. Here we introduce an alternative mechanism based on the coexistence of two homogeneous stable states and spatial coupling. We show the existence of a threshold for perturbations of the homogeneous state. Subthreshold perturbations decay exponentially. Superthreshold perturbations induce the emergence of a long-lived structure formed by two back to back fronts that join the two homogeneous states...
February 2017: Physical Review. E
https://www.readbyqxmd.com/read/28296632/severe-neurologic-disorders-in-2-fetuses-with-zika-virus-infection-colombia
#8
Jorge Acosta-Reyes, Edgar Navarro, Maria José Herrera, Eloina Goenaga, Martha L Ospina, Edgar Parra, Marcela Mercado, Pablo Chaparro, Mauricio Beltran, Maria Luz Gunturiz, Lissethe Pardo, Catalina Valencia, Sandra Huertas, Jorge Rodríguez, Germán Ruiz, Diana Valencia, Lisa B Haddad, Sarah C Tinker, Cynthia A Moore, Hernando Baquero
We report the results of pathologic examinations of 2 fetuses from women in Colombia with Zika virus infection during pregnancy that revealed severe central nervous system defects and potential associated abnormalities of the eye, spleen, and placenta. Amniotic fluid and tissues from multiple fetal organs tested positive for Zika virus.
June 15, 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/28294600/histo-blood-group-antigen-presentation-is-critical-for-norovirus-vlp-binding-to-glycosphingolipids-in-model-membranes
#9
Waqas Nasir, Martin Frank, Angelika Kunze, Marta Bally, Francisco Parra, Per-Georg Nyholm, Fredrik Höök, Göran Larson
Virus entry depends on biomolecular recognition at the surface of cell membranes. In case of glycolipid receptors, these events are expected to be influenced by how the glycan epitope close to the membrane is presented to the virus. This presentation of membrane associated glycans is more restricted as compared to glycans in solution, particularly because of orientational constraints imposed on the glycolipid through its lateral interactions with other membrane lipids and proteins. We have developed and employed total internal reflection fluorescence microscopy (TIRFM) based binding assay and a scheme for molecular dynamics (MD) membrane simulations to investigate the consequences of various glycan presentation effects...
March 15, 2017: ACS Chemical Biology
https://www.readbyqxmd.com/read/28294087/a-large-outbreak-of-acute-gastroenteritis-in-shippensburg-pennsylvania-1972-revisited-evidence-for-common-source-exposure-to-a-recombinant-gii-pg-gii-3-norovirus
#10
J A Johnson, G I Parra, E A Levenson, K Y Green
Historical outbreaks can be an important source of information in the understanding of norovirus evolution and epidemiology. Here, we revisit an outbreak of undiagnosed gastroenteritis that occurred in Shippensburg, Pennsylvania in 1972. Nearly 5000 people fell ill over the course of 10 days. Symptoms included diarrhea, vomiting, stomach cramps, and fever, lasting for a median of 24 h. Using current techniques, including next-generation sequencing of full-length viral genomic amplicons, we identified an unusual norovirus recombinant (GII...
March 15, 2017: Epidemiology and Infection
https://www.readbyqxmd.com/read/28291674/-trigeminal-neuralgia-secondary-to-petrous-endostosis
#11
Jacinto Mata-Gómez, Manuel Royano-Sánchez, Macarena Bejarano-Parra, Ignacio Gilete-Tejero, María Rico-Cotelo, Marta Ortega-Martínez
Arterial neurovascular compression is hypothesised to be the main cause of primary trigeminal neuralgia. Although it is the most common cause, other pathologies, such as tumours in the cerebellopontine angle, can cause trigeminal pain. We report a case of a 44-year-old female patient with right trigeminal neuralgia without satisfactory response to medical treatment. Cerebral MRI showed no structural injuries. During microvascular decompression of the trigeminal nerve, endostosis of the internal aspect of the petrous bone was found to compress the trigeminal nerve...
March 10, 2017: Neurocirugía
https://www.readbyqxmd.com/read/28291614/spatial-and-seasonal-variability-of-ch4-in-the-eastern-gulf-of-cadiz-sw-iberian-peninsula
#12
A Sierra, D Jiménez-López, T Ortega, R Ponce, M J Bellanco, R Sánchez-Leal, A Gómez-Parra, J Forja
Methane (CH4) concentrations were measured along three sections of the eastern Gulf of Cadiz (designated "Guadalquivir", "Sancti Petri" and "Trafalgar") during eight cruises in 2014 and 2015. The concentration of CH4 varied from 3.6 to 19.7nmolkg(-1) (CH4 saturation percent of 122 and 916%), showing seasonal variation. The highest values were found in December 2014 and November 2015. In most of the sampling area the highest concentration of CH4 was found in subsurface waters at depths close to the thermocline, and in the bottom waters near the coast...
March 10, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28291534/ptpn22-1123g-c-polymorphism-and-anti-cyclic-citrullinated-protein-antibodies-in-rheumatoid-arthritis
#13
José Francisco Muñoz-Valle, Jorge Ramón Padilla-Gutiérrez, Jorge Hernández-Bello, Yeniley Ruiz-Noa, Yeminia Valle, Claudia Azucena Palafox-Sánchez, Isela Parra-Rojas, Sergio Ramón Gutiérrez-Ureña, Hector Rangel-Villalobos
BACKGROUND AND OBJECTIVES: The protein tyrosine phosphatase non-receptor type 22 (PTPN22) gene encodes an important negative regulator of T-cell activation, lymphoid-specific phosphatase -Lyp- and has been associated with different autoimmune disorders. The PTPN22 -1123G>C polymorphism appears to affect the transcriptional control of this gene, but to date, the biological significance of this polymorphisms on rheumatoid arthritis (RA) risk remains unknown. We evaluate the association of PTPN22 -1123G>C polymorphism with anti-cyclic citrullinated protein antibodies (anti-CCP) and risk for RA in population from Western Mexico...
March 10, 2017: Medicina Clínica
https://www.readbyqxmd.com/read/28289913/the-impacts-of-exposure-to-environmental-risk-on-physical-and-mental-health-in-a-small-geographic-community-in-houston-tx
#14
Garett Sansom, Juan Parras, Ana Parras, Yudith Nieto, Yvette Arellano, Philip Berke, Thomas McDonald, Eva Shipp, Jennifer A Horney
Previous research has shown that communities with low average socioeconomic status (SES) and majority minority populations are more likely to be exposed to industrial buildings, waste facilities, and poor infrastructure compared to white communities with higher average SES. While some studies have demonstrated linkages between exposures to specific environmental contaminates within these communities and negative health outcomes, little research has analyzed the effects of environmental contaminants on the mental and physical health of these populations...
March 13, 2017: Journal of Community Health
https://www.readbyqxmd.com/read/28288533/attentional-bias-during-emotional-processing-evidence-from-an-emotional-flanker-task-using-iaps
#15
Mario A Parra, Manuel Guillermo Sánchez, Stella Valencia, Natalia Trujillo
Attention is biased towards threat-related stimuli. In three experiments, we investigated the mechanisms, processes, and time course of this processing bias. An emotional flanker task simultaneously presented affective or neutral pictures from the international affective picture system database either as central response-relevant stimuli or surrounding response-uninformative flankers. Participants' response times to central stimuli was measured. The attentional bias was observed when stimuli were presented either for 1500 ms (Experiment 1) or 500 ms (Experiment 2)...
March 14, 2017: Cognition & Emotion
https://www.readbyqxmd.com/read/28284313/one-step-combined-focused-eppcr-and-saturation-mutagenesis-for-thermostability-evolution-of-a-new-cold-active-xylanase
#16
Juan Pablo Acevedo, Manfred T Reetz, Juan A Asenjo, Loreto P Parra
Enzymes active at low temperature are of great interest for industrial bioprocesses due to their high efficiency at a low energy cost. One of the particularities of naturally evolved cold-active enzymes is their increased enzymatic activity at low temperature, however the low thermostability presented in this type of enzymes is still a major drawback for their application in biocatalysis. Directed evolution of cold-adapted enzymes to a more thermostable version, appears as an attractive strategy to fulfill the stability and activity requirements for the industry...
May 2017: Enzyme and Microbial Technology
https://www.readbyqxmd.com/read/28279597/inferior-vena-cava-filters-in-pulmonary-embolism-a-historic-controversy
#17
Carlos Jerjes-Sanchez, David Rodriguez, Aline Navarrete, Carolina Parra-Cantu, Jorge Joya-Harrison, Eduardo Vazquez, Alicia Ramirez-Rivera
OBJECTIVE: Rationale for non-routine use of inferior venous cava filters (IVCF) in pulmonary embolism (PE) patients. METHODS: Thrombosis mechanisms involved with IVCF placement and removal, the blood-contacting medical device inducing clotting, and the inorganic polyphosphate in the contact activation pathway were analyzed. In addition, we analyzed clinical evidence from randomized trials, including patients with and without cancer. Furthermore, we estimated the absolute risk reduction (ARR), the relative risk reduction (RRR), and the number needed to treat (NNT) based on the results of each study using a frequency table...
March 6, 2017: Archivos de Cardiología de México
https://www.readbyqxmd.com/read/28272507/scrutiny-of-mycobacterium-tuberculosis-19-kda-antigen-proteoforms-provides-new-insights-in-the-lipoglycoprotein-biogenesis-paradigm
#18
Julien Parra, Julien Marcoux, Isabelle Poncin, Stéphane Canaan, Jean Louis Herrmann, Jérôme Nigou, Odile Burlet-Schiltz, Michel Rivière
Post-translational modifications (PTMs) are essential processes conditioning the biophysical properties and biological activities of the vast majority of mature proteins. However, occurrence of several distinct PTMs on a same protein dramatically increases its molecular diversity. The comprehensive understanding of the functionalities resulting from any particular PTM association requires a highly challenging full structural description of the PTM combinations. Here, we report the in-depth exploration of the natural structural diversity of the M...
March 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28270247/gut-brain-actions-underlying-comorbid-anxiety-and-depression-associated-with-inflammatory-bowel-disease
#19
Áine Abautret-Daly, Elaine Dempsey, Adolfo Parra-Blanco, Carlos Medina, Andrew Harkin
Introduction Inflammatory bowel disease (IBD) is a chronic relapsing and remitting disorder characterised by inflammation of the gastrointestinal tract. There is a growing consensus that IBD is associated with anxiety- and depression-related symptoms. Psychological symptoms appear to be more prevalent during active disease states with no difference in prevalence between Crohn's disease and ulcerative colitis. Behavioural disturbances including anxiety- and depression-like symptoms have also been observed in animal models of IBD...
March 8, 2017: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/28266588/eeg-in-the-classroom-synchronised-neural-recordings-during-video-presentation
#20
Andreas Trier Poulsen, Simon Kamronn, Jacek Dmochowski, Lucas C Parra, Lars Kai Hansen
We performed simultaneous recordings of electroencephalography (EEG) from multiple students in a classroom, and measured the inter-subject correlation (ISC) of activity evoked by a common video stimulus. The neural reliability, as quantified by ISC, has been linked to engagement and attentional modulation in earlier studies that used high-grade equipment in laboratory settings. Here we reproduce many of the results from these studies using portable low-cost equipment, focusing on the robustness of using ISC for subjects experiencing naturalistic stimuli...
March 7, 2017: Scientific Reports
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