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https://www.readbyqxmd.com/read/29686545/effects-of-eplerenone-on-markers-of-myocardial-fibrosis-6-minute-walk-distance-and-quality-of-life-in-adults-with-tetralogy-of-fallot-and-complete-transposition-of-the-great-arteries
#1
Sandeep S Sodhi, Tony J Zhang, Rachel McDonald, Vanessa Al Rashida, Nitin Kondapalli, Philip Barger, Philip Ludbrook, Ari M Cedars
Ventricular dysfunction is common among patients with repaired cyanotic congenital heart disease. To date, no pharmacologic intervention has been demonstrated to be beneficial in this setting. To begin addressing this knowledge gap, we conducted a single-center prospective, randomized, open-label pilot study to investigate the effects of eplerenone on serologic markers of collagen turnover and inflammation, 6-minute walk distance, and quality of life in patients with tetralogy of Fallot (TOF) or transposition of the great arteries with a systemic right ventricle (transposition of the great arteries [TGA])...
January 2018: Proceedings of the Baylor University Medical Center
https://www.readbyqxmd.com/read/29685887/cardiopulmonary-resuscitation-in-infants-and-children-with-cardiac-disease-a-scientific-statement-from-the-american-heart-association
#2
REVIEW
Bradley S Marino, Sarah Tabbutt, Graeme MacLaren, Mary Fran Hazinski, Ian Adatia, Dianne L Atkins, Paul A Checchia, Allan DeCaen, Ericka L Fink, George M Hoffman, John L Jefferies, Monica Kleinman, Catherine D Krawczeski, Daniel J Licht, Duncan Macrae, Chitra Ravishankar, Ricardo A Samson, Ravi R Thiagarajan, Rune Toms, James Tweddell, Peter C Laussen
Cardiac arrest occurs at a higher rate in children with heart disease than in healthy children. Pediatric basic life support and advanced life support guidelines focus on delivering high-quality resuscitation in children with normal hearts. The complexity and variability in pediatric heart disease pose unique challenges during resuscitation. A writing group appointed by the American Heart Association reviewed the literature addressing resuscitation in children with heart disease. MEDLINE and Google Scholar databases were searched from 1966 to 2015, cross-referencing pediatric heart disease with pertinent resuscitation search terms...
April 23, 2018: Circulation
https://www.readbyqxmd.com/read/29680298/experimental-evaluation-of-homemade-distal-stent-graft-fenestration-for-thoracic-endovascular-aortic-repair-of-type-a-dissection-by-a-transapical-approach
#3
Thomas Gandet, Anis Seghrouchni, Baris Ata Ozdemir, Guillaume Captier, Roland Demaria, Pierre Alric, Bernard Albat, Ludovic Canaud
OBJECTIVE: The use of off-the-shelf stent grafts for thoracic endovascular aortic repair of type A dissections is limited by variability in both the length of the ascending aorta and the location of the proximal intimal tear. This experimental study aimed to assess the feasibility of using a physician-modified thoracic aortic stent graft to treat acute type A dissection by a transapical cardiac approach. METHODS: The experiments were performed on six cadaveric human heart, ascending aorta, aortic arch, and descending aorta specimens...
April 18, 2018: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/29673733/effects-of-dietary-sodium-selenite-and-organic-selenium-sources-on-immune-and-inflammatory-responses-and-selenium-deposition-in-growing-pigs
#4
Michaela Falk, Aksel Bernhoft, Tore Framstad, Brit Salbu, Helene Wisløff, Trond M Kortner, Anja B Kristoffersen, Marianne Oropeza-Moe
The study was conducted to compare effects of different dietary Se sources (sodium selenite [NaSe], Se-enriched yeast [Se yeast] or L-selenomethionine [SeMet]) and one Se-deficient control diet on the expression of selected genes, hematological and clinical biochemical parameters, and muscle morphology in two parallel trials with finisher pigs. Se concentrations in blood plasma and tissues were also monitored. From the pigs in one of the parallel groups, muscle samples obtained from Musculus longissimus dorsi (LD) before and during the trial were examined...
March 8, 2018: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/29666358/revisiting-atrioventricular-nodal-ablation-and-cardiac-pacing-of-atrial-fibrillation-in-a-patient-with-dextrocardia
#5
Munish Sharma, Ritesh Neupane, Koroush Khalighi
BACKGROUND Poorly controlled ventricular rate associated with atrial fibrillation (AF) leads to tachycardia-induced left ventricular dysfunction. Atrioventricular (AV) nodal ablation and cardiac pacing is the standard of care in refractory congestive heart failure (CHF) due to AF with moderate to rapid ventricular response that failed conventional medical therapy. If the patient is not a candidate for AF ablation with pulmonary vein isolation and elimination of AF foci, this is an effective approach, but it does have some challenges when done in a patient with dextrocardia and situs inversus...
April 18, 2018: American Journal of Case Reports
https://www.readbyqxmd.com/read/29663677/the-carotid-sinus-nerve-structure-function-and-clinical-implications
#6
Andrea Porzionato, Veronica Macchi, Carla Stecco, Raffaele De Caro
Interest has been renewed in the anatomy and physiology of the carotid sinus nerve (CSN) and its targets (carotid sinus and carotid body), due to recent proposals of surgical procedures for a series of common pathologies, such as carotid sinus syndrome, hypertension, heart failure and insulin resistance. The CSN originates from the glossopharyngeal nerve soon after its appearance from the jugular foramen. It shows frequent communications with the sympathetic trunk (usually at the level of the superior cervical ganglion) and the vagal nerve (main trunk, pharyngeal branches or superior laryngeal nerve)...
April 16, 2018: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
https://www.readbyqxmd.com/read/29657908/a-rare-case-of-coronary-artery-embolism-in-a-patient-with-d-transposition-of-the-great-arteries-with-prior-mustard-repair
#7
Prince Sethi, Udit Bhatnagar, Kelly Steffen, Edgard Bendaly, Adam Stys
The dextro-transposition of great arteries (d-TGA) is a rare, congenital, cyanotic heart disease and there is a paucity of data regarding long-term cardiovascular outcomes. We present a rare case of non-ST-elevation myocardial infarction (NSTEMI) in a patient with surgically repaired d-TGA. A 43-year-old male who had previously undergone a Mustard atrial switch palliative procedure presented with chest pain and diaphoresis and was diagnosed with NSTEMI. A coronary angiogram revealed a small, underdeveloped, left anterior descending and a large, left circumflex coronary artery with an acute embolic lesion...
February 12, 2018: Curēus
https://www.readbyqxmd.com/read/29655572/3d-modelling-and-printing-technology-to-produce-patient-specific-3d-models
#8
Nicolette S Birbara, James M Otton, Nalini Pather
BACKGROUND: A comprehensive knowledge of mitral valve (MV) anatomy is crucial in the assessment of MV disease. While the use of three-dimensional (3D) modelling and printing in MV assessment has undergone early clinical evaluation, the precision and usefulness of this technology requires further investigation. This study aimed to assess and validate 3D modelling and printing technology to produce patient-specific 3D MV models. METHODS: A prototype method for MV 3D modelling and printing was developed from computed tomography (CT) scans of a plastinated human heart...
November 10, 2017: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/29653112/a-comparison-of-two-types-of-running-wheel-in-terms-of-mouse-preference-health-and-welfare
#9
Michael Walker, Georgia Mason
Voluntary wheel running occurs in mice of all strains, sexes, and ages. Mice find voluntary wheel running rewarding, and it leads to numerous health benefits. For this reason wheels are used both to enhance welfare and to create models of exercise. However, many designs of running wheel are used. This makes between-study comparisons difficult, as this variability could potentially affect the amount, pattern, and/or intensity of running behaviour, and thence the wheels' effects on welfare and exercise-related changes in anatomy and physiology...
April 10, 2018: Physiology & Behavior
https://www.readbyqxmd.com/read/29642695/tricuspid-valve-imaging
#10
Francesco Ancona, Stefano Stella, Cristina Capogrosso, Claudia Marini, Andrea Fisicaro, Alberto Margonato, Paolo Denti, Eustachio Agricola
The right ventricle and tricuspid valve (TV) have long been neglected by cardiologists. Functional tricuspid regurgitation (TR) is nowadays the most common cause of severe TR and is emerging as a prognostic factor in many heart diseases. A multimodality imaging approach is fundamental for defining the pathophysiology of TR, using both 2-dimensional and 3-dimensional (3D) echocardiography, as well as CT scan. In particular, 3D echocardiography can characterize TV apparatus and tricuspid annulus; CT offers complementary information about annular structure, and its relationship with the right coronary artery...
April 11, 2018: Minerva Cardioangiologica
https://www.readbyqxmd.com/read/29642691/high-risk-pci-how-to-define-it-today
#11
Vincenzo DE Marzo, Domenico D'Amario, Mattia Galli, Rocco Vergallo, Italo Porto
Before the percutaneous spread, the mortality rate of patients with coronary heart disease not suitable for cardiac surgery was markedly high. This limit has been progressively exceeded with the advent of minimally invasive approaches, which, although was initially intended exclusively for low risk patients, was then employed in complex patients often too compromised to undergo cardiac surgery. Given to the rising of high-risk population, due to an increase of patients with multiple chronic conditions linked to the best care offered, we are witnessing an expansion of the high-risk percutaneous coronary interventions (PCI) population...
April 11, 2018: Minerva Cardioangiologica
https://www.readbyqxmd.com/read/29627871/autonomic-regulation-and-ventricular-arrhythmias
#12
REVIEW
Lingjin Meng, Kalyanam Shivkumar, Olujimi Ajijola
Autonomic nervous system (ANS) has a crucial role of regulating cardiac function in the physiological state and contributes to the pathogenesis of arrhythmias in the diseased state. The cardiac neuraxis consists of multiple feedback loops consisting of efferent and afferent limbs, mediating neurotransmission to and from the heart. Efferent parasympathetic neurotransmission is mediated by the vagus nerve, while paravertebral sympathetic ganglia relay efferent sympathetic neurotransmission to the heart. The association between autonomic activity and ventricular arrhythmias (VAs) has been studied extensively in both experimental models and humans...
April 7, 2018: Current Treatment Options in Cardiovascular Medicine
https://www.readbyqxmd.com/read/29627180/transatrial-implantation-of-a-transcatheter-heart-valve-for-severe-mitral-annular-calcification
#13
Fabien Praz, Omar K Khalique, Raymond Lee, Ramesh Veeragandham, Hyde Russell, Mayra Guerrero, Ashequl M Islam, David W Deaton, Tsuyoshi Kaneko, Susheel K Kodali, Martin B Leon, Vinayak Bapat, Hiroo Takayama, Michael A Borger, Isaac George
OBJECTIVE: To assess the outcomes of transatrial implantation of a transcatheter heart valve (THV) for the treatment of mitral valve disease with severe mitral annular calcification (MAC). METHODS: Implantation of a balloon-expandable THV was performed on cardiopulmonary bypass via left atrial exposure in patients considered at risk for left ventricular outflow tract obstruction. The anterior mitral valve leaflet was systematically resected and pledgeted sutures were placed to enhance stability and reduce paravalvular leak...
March 12, 2018: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29623540/patient-specific-catheter-shaping-for-the-minimally-invasive-closure-of-the-left-atrial-appendage
#14
Eva C Graf, Ilka Ott, Julian Praceus, Felix Bourier, Tim C Lueth
PURPOSE: The minimally invasive closure of the left atrial appendage is a promising alternative to anticoagulation for stroke prevention in patients suffering from atrial fibrillation. One of the challenges of this procedure is the correct positioning and the coaxial alignment of the tip of the catheter sheath to the implant landing zone. METHOD: In this paper, a novel preoperative planning system is proposed that allows patient-individual shaping of catheters to facilitate the correct positioning of the catheter sheath by offering a patient-specific catheter shape...
April 5, 2018: International Journal of Computer Assisted Radiology and Surgery
https://www.readbyqxmd.com/read/29607159/application-of-3d-printing-in-the-surgical-planning-of-hypertrophic-obstructive-cardiomyopathy-and-physician-patient-communication-a-preliminary-study
#15
Hong-Chang Guo, Yang Wang, Jiang Dai, Chang-Wei Ren, Jin-Hua Li, Yong-Qiang Lai
Background: The aim of this study was to evaluate the effect of 3-dimensional (3D) printing in treatment of hypertrophic obstructive cardiomyopathy (HOCM) and its roles in doctor-patient communication. Methods: 3D-printed models were constructed preoperatively and postoperatively in seven HOCM patients received surgical treatment. Based on multi-slice computed tomography (CT) images, regions of disorder were segmented using the Mimics 19.0 software (Materialise, Leuven, Belgium)...
February 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29603279/long-term-therapy-with-teduglutide-in-parenteral-support-dependent-patients-with-short-bowel-syndrome-a-case-series
#16
Andrew Ukleja, Chau To, Alicia Alvarez, Luis F Lara
OBJECTIVE: To review all cases of parenteral support (PS)-dependent patients with short bowel syndrome (SBS) treated with teduglutide (Gattex®, Shire) and to evaluate its efficacy and adverse effects. METHODS: This is a retrospective descriptive cohort of SBS patients treated with teduglutide. Demographics, bowel length, primary diagnosis, PS volume/duration, teduglutide dose, and side effects were collected prospectively. RESULTS: Six SBS patients (4 females, 2 males) received teduglutide...
March 30, 2018: JPEN. Journal of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29579186/arrhythmias-in-congenital-heart-disease-a-position-paper-of-the-european-heart-rhythm-association-ehra-association-for-european-paediatric-and-congenital-cardiology-aepc-and-the-european-society-of-cardiology-esc-working-group-on-grown-up-congenital-heart-disease
#17
Antonio Hernández-Madrid, Thomas Paul, Dominic Abrams, Peter F Aziz, Nico A Blom, Jian Chen, Massimo Chessa, Nicolas Combes, Nikolaos Dagres, Gerhard Diller, Sabine Ernst, Alessandro Giamberti, Joachim Hebe, Jan Janousek, Thomas Kriebel, Jose Moltedo, Javier Moreno, Rafael Peinado, Laurent Pison, Eric Rosenthal, Jonathan R Skinner, Katja Zeppenfeld
The population of patients with congenital heart disease (CHD) is continuously increasing with more and more patients reaching adulthood. A significant portion of these young adults will suffer from arrhythmias due to the underlying congenital heart defect itself or as a sequela of interventional or surgical treatment. The medical community will encounter an increasing challenge as even most of the individuals with complex congenital heart defects nowadays become young adults. Within the past 20 years, management of patients with arrhythmias has gained remarkable progress including pharmacological treatment, catheter ablation, and device therapy...
March 20, 2018: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/29572087/utility-of-dual-source-computed-tomography-in-cardiac-resynchronization-therapy-direct-study
#18
Quynh A Truong, Jackie Szymonifka, Michael H Picard, Wai-Ee Thai, Bryan Wai, Jim W Cheung, E Kevin Heist, Udo Hoffmann, Jagmeet P Singh
BACKGROUND: Dual-source computed tomography (CT) can evaluate left ventricular (LV) dyssynchrony, myocardial scar and coronary venous anatomy in patients undergoing cardiac resynchronization therapy (CRT). OBJECTIVE: We aim to determine if dual-source CT predicts clinical CRT outcomes and reduces intra-procedural time. METHODS: In this prospective study, 54 patients scheduled for CRT (age 63±11, 74% male) underwent pre-procedural CT to assess their venous anatomy as well as CT-derived dyssynchrony metrics and myocardial scar...
March 20, 2018: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/29569368/optimal-reconstruction-of-left-ventricular-outflow-tract-obstruction-before-surgical-myectomy-in-a-case-with-hypertrophic-obstructive-cardiomyopathy
#19
Hiroyuki Toh, Shumpei Mori, Shinsuke Shimoyama, Yu Izawa, Shun Yokota, Yuto Shinkura, Ryo Takeshige, Akira Nagasawa, Fumitaka Soga, Hidekazu Tanaka, Toshiro Shinke, Koki Yokawa, Takashi Matsueda, Yutaka Okita, Ken-Ichi Hirata
We present optimally reconstructed three-dimensional computed tomography images of left ventricular outflow obstruction, comprehensive left ventriculography, and comparable intraoperative transesophageal echocardiography, as well as serial operative pictures, to facilitate the understanding of live-heart anatomy of hypertrophic obstructive cardiomyopathy. As shown in this case, detailed morphological analysis around the left ventricular outflow tract using preoperative computed tomography would be feasible and useful...
March 22, 2018: Echocardiography
https://www.readbyqxmd.com/read/29566796/cerebral-embolic-risk-during-transcatheter-mitral-valve-interventions-an-unaddressed-and-unmet-clinical-need
#20
REVIEW
Matteo Pagnesi, Damiano Regazzoli, Marco B Ancona, Antonio Mangieri, Giuseppe Lanzillo, Francesco Giannini, Nicola Buzzatti, Bernard D Prendergast, Susheel Kodali, Alexandra J Lansky, Antonio Colombo, Azeem Latib
As new transcatheter mitral valve (MV) interventions continuously evolve, potential procedure-related adverse events demand careful investigation. The risk of cerebral embolic damage is ubiquitous in any left-sided structural heart intervention (and potentially linked to long-term neurocognitive sequelae); therefore, efforts to evaluate these aspects in the field of catheter-based MV procedures are justified. Given the peculiarities of MV anatomy, MV disease, and MV procedures, the lessons learned from other transcatheter heart interventions (i...
March 26, 2018: JACC. Cardiovascular Interventions
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