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https://www.readbyqxmd.com/read/28749353/mesh-denoising-with-geo-metric-fidelity
#1
Marco Centin, Alberto Signoroni
Working with noisy meshes and aiming at providing high-fidelity 3D object models without tampering the metric quality of the acquisitions, we propose a mesh denoising technique that, through a normal-diffusion process guided by a curvature saliency map, is able to preserve and emphasize the natural object features, concurrently allowing the introduction of a bound on the maximum distance from the original model. Moreover, both the position of the mesh vertices and the edge orientations are optimized through a tailored geometric-aliasing correction...
July 25, 2017: IEEE Transactions on Visualization and Computer Graphics
https://www.readbyqxmd.com/read/28746136/using-organizational-philosophy-to-create-a-self-sustaining-compensation-plan-without-harming-academic-missions
#2
Robert Leverence, Richard Nuttall, Rachel Palmer, Mark Segal, Alicia Wood, Fay Yancey, Jonathon Shuster, Mark Brantly, Robert Hromas
PROBLEM: Academic physician reimbursement has moved to productivity-based compensation plans. To be sustainable, such plans must be self-funding. Additionally, unless research and education are appropriately valued, faculty involved in these efforts will become disillusioned, yet revenue generation in these activities is less robust than for clinical care activities. APPROACH: Faculty at the Department of Medicine, University of Florida Health, elected a committee of junior and senior faculty and division chiefs to restructure the compensation plan in fiscal year (FY) 2011...
August 2017: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/28745402/fat-based-registration-of-breast-dynamic-contrast-enhanced-water-images
#3
Subashini Srinivasan, Brian A Hargreaves, Bruce L Daniel
PURPOSE: In this study, a 3D fat-based deformable registration algorithm was developed for registering dynamic contrast-enhanced breast images. METHODS: The mutual information similarity measure with free-form deformation motion correction in rapidly enhancing lesions can introduce motion. However, in Dixon-based fat-water separated acquisitions, the nonenhancing fat signal can directly be used to estimate deformable motion, which can be later used to deform the water images...
July 26, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28744842/the-quantitative-structural-and-compositional-analyses-of-degenerating-intervertebral-discs-using-magnetic-resonance-imaging-and-contrast-enhanced-micro-computed-tomography
#4
Kevin H Lin, Simon Y Tang
The intervertebral disc (IVD) is susceptible to degenerative changes that are associated with low back pain. Murine models are often used to investigate the mechanistic changes in the development, aging, and diseased states of the IVD, yet the detection of early degenerative changes in structure is challenging because of the minute size of the murine IVDs. Histology is the gold standard for examining the IVD structure, but it is susceptible to sectioning artifacts, spatial biases, and requires the destructive preparation of the sample...
July 25, 2017: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/28744160/impact-of-abiraterone-on-patient-related-outcomes-in-metastatic-castration-resistant-prostate-cancer-current-perspectives
#5
REVIEW
Joelle El-Amm, Rami Nassabein, Jeanny B Aragon-Ching
Abiraterone acetate has established a major role in the treatment paradigm of metastatic castration-resistant prostate cancer ever since pivotal trials, COU-AA-301 and COU-AA-302, have shown benefit in both the second-line and first-line (post- and pre-chemotherapy) setting, respectively, with improvement in overall survival as well as secondary end points such as prostate-specific antigen (PSA) and radiographic response rates, time to PSA progression, and progression-free survival. There has been a lot of interest and emphasis in the evaluation of patient-related outcomes (PROs) as it relates to quality of life, pain, adverse events, fatigue, and among others, in the use of different agents that have been shown to improve survival...
2017: Cancer Management and Research
https://www.readbyqxmd.com/read/28743898/achievement-of-sustained-net-plasma-heating-in-a-fusion-experiment-with-the-optometrist-algorithm
#6
E A Baltz, E Trask, M Binderbauer, M Dikovsky, H Gota, R Mendoza, J C Platt, P F Riley
Many fields of basic and applied science require efficiently exploring complex systems with high dimensionality. An example of such a challenge is optimising the performance of plasma fusion experiments. The highly-nonlinear and temporally-varying interaction between the plasma, its environment and external controls presents a considerable complexity in these experiments. A further difficulty arises from the fact that there is no single objective metric that fully captures both plasma quality and equipment constraints...
July 25, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28743024/a-method-to-evaluate-the-quality-of-clinical-gene-panel-sequencing-data-for-single-nucleotide-variant-detection
#7
Chung Lee, Joon S Bae, Gyu H Ryu, Nayoung K D Kim, Donghyun Park, Jongsuk Chung, Sungkyu Kyung, Je-Gun Joung, Hyun-Tae Shin, Seung-Ho Shin, Younglan Kim, Byung S Kim, Hojun Lee, Kyoung-Mee Kim, Jung-Sun Kim, Woong-Yang Park, Dae-Soon Son
Customized gene-panel tests, based on next-generation sequencing, have demonstrated their usefulness in a plethora of clinical settings. As with other clinical diagnostic techniques, gene-panel sequencing for clinical purposes requires precise quality control (QC) measures to ensure its reliability. Only detected variants are currently recorded in clinical reports; however, identifying whether a nondetected variant is a true or false negative is regarded essential in a clinical setting and, thus, a comprehensive QC measure is in demand...
July 22, 2017: Journal of Molecular Diagnostics: JMD
https://www.readbyqxmd.com/read/28742867/assessing-unmet-needs-in-patients-with-cancer-an-investigation-of-differential-item-functioning-of-the-needs-evaluation-questionnaire-across-gender-age-and-phase-of-the-disease
#8
Francesca Chiesi, Andrea Bonacchi, Caterina Primi, Guido Miccinesi
OBJECTIVE: The main aim of this study was to provide evidence of the broad employability of the NEQ with patients of different gender and age with cancer in different phases of the disease and care process, using an Item Response Theory (IRT) approach and investigating Differential Item Functioning (DIF). METHODS: The NEQ was completed by 762 patients visiting, consecutively, outpatient clinics or admitted to oncology wards. Patients included in the study had different primary tumor sites and were in different phases of the disease and care process...
2017: PloS One
https://www.readbyqxmd.com/read/28742856/fit-for-genomic-and-proteomic-purposes-sampling-the-fitness-of-nucleic-acid-and-protein-derivatives-from-formalin-fixed-paraffin-embedded-tissue
#9
Anna Yakovleva, Jordan L Plieskatt, Sarah Jensen, Razan Humeida, Jonathan Lang, Guangzhao Li, Paige Bracci, Sylvia Silver, Jeffrey Michael Bethony
The demand for nucleic acid and protein derivatives from formalin-fixed paraffin-embedded (FFPE) tissue has greatly increased due to advances in extraction and purification methods, making these derivatives available for numerous genomic and proteomic platforms. Previously, DNA, RNA, microRNA (miRNA), or protein derived from FFPE tissue blocks were considered "unfit" for such platforms, as the process of tissue immobilization by FFPE resulted in cross-linked, fragmented, and chemically modified macromolecules...
2017: PloS One
https://www.readbyqxmd.com/read/28741863/development-of-quality-metrics-for-ambulatory-pediatric-cardiology-infection-prevention
#10
Jonathan N Johnson, Cindy S Barrett, Wayne H Franklin, Eric M Graham, Nancy J Halnon, Brandy A Hattendorf, Catherine D Krawczeski, James J McGovern, Matthew J O'Connor, Amy H Schultz, Jeffrey M Vinocur, Devyani Chowdhury, Jeffrey B Anderson
INTRODUCTION: In 2012, the American College of Cardiology's (ACC) Adult Congenital and Pediatric Cardiology Council established a program to develop quality metrics to guide ambulatory practices for pediatric cardiology. The council chose five areas on which to focus their efforts; chest pain, Kawasaki Disease, tetralogy of Fallot, transposition of the great arteries after arterial switch, and infection prevention. Here, we sought to describe the process, evaluation, and results of the Infection Prevention Committee's metric design process...
July 25, 2017: Congenital Heart Disease
https://www.readbyqxmd.com/read/28738841/identifying-and-mitigating-batch-effects-in-whole-genome-sequencing-data
#11
Jennifer A Tom, Jens Reeder, William F Forrest, Robert R Graham, Julie Hunkapiller, Timothy W Behrens, Tushar R Bhangale
BACKGROUND: Large sample sets of whole genome sequencing with deep coverage are being generated, however assembling datasets from different sources inevitably introduces batch effects. These batch effects are not well understood and can be due to changes in the sequencing protocol or bioinformatics tools used to process the data. No systematic algorithms or heuristics exist to detect and filter batch effects or remove associations impacted by batch effects in whole genome sequencing data...
July 24, 2017: BMC Bioinformatics
https://www.readbyqxmd.com/read/28735805/impact-of-definition-and-timeframe-on-capturing-surgery-related-readmissions-after-primary-joint-arthroplasty
#12
Brian P Chen, Johanna Dobransky, Stephane Poitras, Alan Forster, Paul E Beaulé
BACKGROUND: Readmission rate has emerged as an important metric to measure quality, but varying definitions and timeframes are used. We aimed to evaluate the impact of different readmission definitions (postoperative vs postdischarge) and timeframes (30 vs 90-day) on capturing surgery-related readmissions after primary total joint arthroplasty. METHODS: Patients who underwent primary total hip or knee arthroplasty between January 1, 2013 and December 31, 2015 were included...
July 5, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28735218/strength-of-linguistic-text-evidence-a-fused-forensic-text-comparison-system
#13
Shunichi Ishihara
Compared to other forensic comparative sciences, studies of the efficacy of the likelihood ratio (LR) framework in forensic authorship analysis are lagging. An experiment is described concerning the estimation of strength of linguistic text evidence within that framework. The LRs were estimated by trialling three different procedures: one is based on the multivariate kernel density (MVKD) formula, with each group of messages being modelled as a vector of authorship attribution features; the other two involve N-grams based on word tokens and characters, respectively...
July 8, 2017: Forensic Science International
https://www.readbyqxmd.com/read/28733337/inpatient-quality-metrics-in-neurology-a-grand-challenge
#14
EDITORIAL
Paul M Vespa, John Ferro, S Andrew Josephson
No abstract text is available yet for this article.
July 21, 2017: Neurology
https://www.readbyqxmd.com/read/28733188/assay-stability-the-missing-component-of-the-error-budget
#15
Mackay Mark, Hegedus Gabe, Badrick Tony
Gaining a better understanding of Quality Control (QC) processes is a key requirement to improving performance and reducing patient risk. Detecting analytical error is dependent on a QC strategy that reliably detects a critical shift in a result away from the true value. Recently the concept of Six Sigma has been used by diagnostic laboratories to assess the performance of assays and to assist in the selection of QC rules. The sigma metric is one measure of an assay's ability to perform within specification...
July 18, 2017: Clinical Biochemistry
https://www.readbyqxmd.com/read/28731529/association-between-systemic-antibiotic-and-corticosteroid-use-for-chronic-rhinosinusitis-and-quality-of-life
#16
Alisa Yamasaki, Lloyd P Hoehle, Katie M Phillips, Allen L Feng, Adam P Campbell, David S Caradonna, Stacey T Gray, Ahmad R Sedaghat
OBJECTIVE: We sought to establish the significance of querying chronic rhinosinusitis (CRS) patients about their past CRS-related oral antibiotic and corticosteroid usage by determining the association between these metrics and patients' quality of life (QoL). STUDY DESIGN: Cross-sectional study. METHODS: A total of 157 patients with CRS were prospectively recruited. CRS-specific QoL was measured using the 22-item Sinonasal Outcome Test (SNOT-22)...
July 21, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28731267/heuristic-knowledge-based-planning-for-single-isocenter-stereotactic-radiosurgery-to-multiple-brain-metastases
#17
Benjamin P Ziemer, Parag Sanghvi, Jona Hattangadi-Gluth, Kevin L Moore
PURPOSE: Single-isocenter, volumetric modulated arc therapy (VMAT) stereotactic radiosurgery (SRS) for multiple brain metastases (multi-mets) can deliver highly conformal dose distributions and reduce overall patient treatment time compared to other techniques. However, treatment planning for multi-met cases is highly complex due to variability in numbers and sizes of brain metastases, as well as their relative proximity to organs-at-risk (OARs). The purpose of this study was to automate the VMAT planning of multi-met cases through a knowledge-based planning (KBP) approach that adapts single target SRS dose predictions to multiple target predictions...
July 21, 2017: Medical Physics
https://www.readbyqxmd.com/read/28730718/impact-of-binding-mechanism-on-selective-inhibition-of-histone-deacetylase-isoforms
#18
Christian Meyners, Franz-Josef Meyer-Almes
Industrialized drug screening campaigns usually deliver hundreds of compounds that are active on a particular pharmaceutical target. In light of high failure rates of drug candidates due to unforeseeable off-target toxicity, the early identification of the most promising compounds with high potential for target selectivity is an urgent need to improve the quality of lead compounds and lower attrition rates in the drug development process. The reliable prediction of the selectivity of active substances for a target protein is a challenging task...
June 14, 2017: Chemical Biology & Drug Design
https://www.readbyqxmd.com/read/28729849/nerve-decompression-and-restless-legs-syndrome-a-retrospective-analysis
#19
James C Anderson, Megan L Fritz, John-Michael Benson, Brian L Tracy
INTRODUCTION: Restless legs syndrome (RLS) is a prevalent sleep disorder affecting quality of life and is often comorbid with other neurological diseases, including peripheral neuropathy. The mechanisms related to RLS symptoms remain unclear, and treatment options are often aimed at symptom relief rather than etiology. RLS may present in distinct phenotypes often described as "primary" vs. "secondary" RLS. Secondary RLS is often associated with peripheral neuropathy. Nerve decompression surgery of the common and superficial fibular nerves is used to treat peripheral neuropathy...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28729099/implementing-a-cervical-sentinel-lymph-node-biopsy-program-quality-improvement-in-gynaecologic-oncology
#20
Maria C Cusimano, Rachel Walker, Marcus Q Bernardini, Geneviève Bouchard-Fortier, Stephane Laframboise, Taymaa May, Joan Murphy, Barry Rosen, Al Covens, Blaise Clarke, Patricia Shaw, Marjan Rouzbahman, Ravi Mohan, Sarah E Ferguson
OBJECTIVE: Sentinel lymph node (SLN) biopsy is becoming a reasonable alternative to pelvic lymphadenectomy in early-stage cervical cancer. It is therefore imperative that centres without prior experience are able to successfully implement the procedure. The objectives of the current study were to (1) describe the process of implementing an SLN biopsy program with a novel peer mentorship component and (2) assess post-program quality improvement metrics, including SLN detection rate (DR) and diagnostic parameters...
August 2017: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
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